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Your search keyword '"Fong, Harry H.S."' showing total 190 results
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190 results on '"Fong, Harry H.S."'

5. Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model

Author

Yanga, Jia-Ming, Xian, Yan-Fang, Ip, Paul S.P., Wu, Justin C.Y., Lao, Lixing, Fong, Harry H.S., Sung, Joseph J.Y., Berman, Brian, Yeung, John H.K., and Che, Chun-Tao

Subjects
Materia medica, Vegetable -- Health aspects -- Research, Schisandra -- Research, Allergic reaction -- Care and treatment -- Research, Allergy -- Care and treatment -- Research, Plant extracts -- Health aspects -- Research, Biological sciences, Health, Science and technology
Abstract

ARTICLE INFO Keywords: Schisandra chinensis Visceral hypersensitivity Neonatal maternal separation 5-HT ABSTRACT Visceral hypersensitivity is an important characteristic feature of functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). This [...]

Published
2012
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7. Ensuring the safety of botanical dietary supplements

Author

van Breemen, Richard B., Fong, Harry H.S., and Farnsworth, Norman R.

Subjects
Alternative medicine -- Research, Dietary supplements -- Safety and security measures, Food/cooking/nutrition, Health
Abstract

Botanical dietary supplements with a history of safe human use may not require the same level of toxicity testing as synthetic pharmaceutical drugs. Most of the documented examples of acute toxicity caused by botanical dietary supplements have been caused by the substitution of toxic plants for the desired species, probably through misidentification or production errors, or by contamination with pharmaceutical agents, either as a result of poor manufacturing practices or adulteration. Although more difficult to document, chronic toxicities attributed to botanical dietary supplements may be caused by contamination by heavy metals, pesticides, or microbes or by inherent properties of constituents of the botanicals themselves. Like drug-drug interactions, botanical-drug interactions can also be a source of toxicity. Most of these toxicity problems may be prevented by implementing good agricultural practices and good manufacturing practices and applying existing toxicity testing similar to those used in drug development or new toxicity assays under development based on proteomics, genomics, or metabolomics. KEY WORDS Safety, toxicity, botanical dietary supplements, complementary and alternative medicine, hepatoxicity, metabolic activation

Published
2008

8. Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed

Author

Rickard, Sharon E., Orcheson, Lindy J., Seidl, Maja M., Luyengi, Lumonadio, Fong, Harry H.S., and Thompson, Lilian U.

Subjects
Rats -- Physiological aspects, Urine -- Analysis, Food/cooking/nutrition
Abstract

The mammalian lignans enterodiol (ED) and enterolactone (EL) produced from colonic bacterial action on dietary precursors have exhibited anticarcinogenic effects in vitro. The major lignan precursor in flaxseed (a rich source) has been identified as secoisolariciresinol diglycoside (SDG). The purpose of this study was to first isolate SDG and determine whether 1) SDG accounted for all the lignan production from flaxseed; 2) this production was dose-related; and 3) a relationship between in vitro production and in vivo urinary excretion existed. Extraction of flaxseed with dioxane:ethanol (1:1, v/v) followed by chromatographic separations yielded the purified SDG. Rats were fed a high fat diet without/with 2.5, 5 or 10 g/100g ground flaxseed or 1.1, 2.2 or 4.4 SDG/d (equivalent to levels in the respective flaxseed diets) for 4 wk. In vitro lignan production was assessed by fermenting flaxseed or SDG for 24 h with human fecal inoculum. Urinary lignan excretion increased linearly with doses from 0-5% flaxseed and 0-2.2 [[micro]mol] SDG/d followed by a plateau, indicating a threshold response. When all doses were considered, a curvilinear relationship was observed. A similar trend was seen in vitro for SDG, resulting in a high correlation between in vitro production and in vivo excretion of lignans (r = 0.990, P [less than] 0.02). Thus in vivo response can be predicted with confidence based on in vitro results. Theoretical urinary ED + EL from the SDG present in flaxseed correlated with the actual excretion in flaxseed-fed animals (r = 0.655, P [less than] 0.005). However, urinary ED + EL of SDG-fed rats was only 20% of levels of flaxseed-fed rats, indicating the presence of other precursors or incomplete conversion of SDG to ED and EL. J. Nutr. 126: 2012-2019, 1996. INDEXING KEY WORDS: flaxseed; lignans; urine; in vitro fermentation; rats

Published
1996

9. Electrospray liquid chromatography/mass spectrometry of ginsenosides

Author

Breemen, Richard B. van, Huang, Chao-Ran, Lu, Zhi-Zhen, Rimando, Agnes, Fong, Harry H.S., and Fitzloff, John F.

Subjects
Ginseng -- Research, Liquid chromatography -- Research, Mass spectrometry -- Research, Chemistry
Abstract

An electrospray liquid chromatography/mass spectrometry (LC/MS) method has been developed for the analysis of ginseng saponins (ginsenosides) contained in extracts of the root of Panax ginseng (Korean ginseng) and Panax quinquefolius (American ginseng). The LC/MS method consists of separation of ginsenosides using an (aminopropyl)silica HPLC column, followed by detection using a photodiode array UV absorbance detector and then on-line electrospray mass spectrometry. Ginsenosides eluted from the HPLC column in order of increasing molecular weight and were detected as [[M + Na].sup.+] or [[M + 138].sup.+] adducts. Occurrence of [[M + 138].sup.+] adducts was most prominent when new HPLC columns were used, and none were observed when solutions of ginsenoside standards were infused into the mass spectrometer without use of HPLC. The cation weighing 138 was identified as (3-ammoniumpropyl)trihydroxysilane, +N[H.sub.4] [(C[H.sub.2]).sub.3]Si[(OH).sub.3], which was either a byproduct of stationary phase synthesis or a stationary phase degradation product. LC/MS chromatograms of extracts of Korean ginseng and American ginseng demonstrated substantial differences between the relative amounts of each ginsenoside. Based on molecular weight and coelution with standards, ginsenosides [Rg.sub.1], [R.sub.e], [R.sub.d], [R.sub.c], [R.sub.b2], and [R.sub.b1] (in order of elution from the HPLC column) were identified in both ginseng extracts. Four other ginsenosides were detected by mass spectrometry for which no standards were available, and their molecular weights were 801 (possibly corresponding to ginsenoside [R.sub.f]), 817, 947, and 963 (possibly 20-gluco-[R.sub.f]). The ginsenosides weighing 817 and 963 were detected only in the Korean ginseng extract.

Published
1995

10. Hawthorn

Author

Fong, Harry H.S. and Bauman, Jerry L.

Subjects
Hawthorns -- Dosage and administration, Medicinal plants -- Dosage and administration, Cardiovascular diseases -- Care and treatment, Business, Health, Health care industry
Published
2002

21. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Author

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W.W., Fong, Harry H.S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., and Pezzuto, John M.

Subjects
Antineoplastic agents -- Research, Chemotherapy -- Research, Cancer -- Chemotherapy, Antimitotic agents -- Research, Science and technology, Research
Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase 11 drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans., Cancer is the largest single cause of death in both men and women, claiming over 6 million lives each year worldwide. Chemoprevention, the prevention of cancer by ingestion of chemical [...]

Published
1997

23. Bioactive Constituents fromRadermachera boniana.

Author

Wang, Ming-Zhong, primary, Xie, Wen-Jian, additional, Guan, Yi-Fu, additional, Song, Xun, additional, Hung, Nguyen Van, additional, Cuong, Nguyen Manh, additional, Santarsiero, Bernard D., additional, Fong, Harry H.S., additional, Soejarto, D. Doel, additional, and Zhang, Hong-Jie, additional

Published
2016
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24. Bioassay‐Guided Isolation and Structural Modification of the Anti‐TB Resorcinols from Ardisia gigantifolia

Author

Guan, Yi‐Fu, primary, Song, Xun, additional, Qiu, Ming‐Hua, additional, Luo, Shi‐Hong, additional, Wang, Bao‐Jie, additional, Van Hung, Nguyen, additional, Cuong, Nguyen M., additional, Soejarto, Djaja Doel, additional, Fong, Harry H.S., additional, Franzblau, Scott G., additional, Li, Sheng‐Hong, additional, He, Zhen‐Dan, additional, and Zhang, Hong‐Jie, additional

Published
2016
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25. Litsea Species as Potential Antiviral Plant Sources

Author

Guan, Yifu, primary, Wang, Dongying, additional, Tan, Ghee T., additional, Van Hung, Nguyen, additional, Cuong, Nguyen Manh, additional, Pezzuto, John M., additional, Fong, Harry H.S., additional, Soejarto, Djaja Doel, additional, and Zhang, Hongjie, additional

Published
2016
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30. Phytoconstituents from Vitex agnus-castus fruits

Author

Chen, Shao-Nong, primary, Friesen, J. Brent, additional, Webster, Donna, additional, Nikolic, Dejan, additional, van Breemen, Richard B., additional, Wang, Z. Jim, additional, Fong, Harry H.S., additional, Farnsworth, Norman R., additional, and Pauli, Guido F., additional

Published
2011
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32. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata

Author

Yang, Jian-Hong, primary, Kondratyuk, Tamara P., additional, Marler, Laura E., additional, Qiu, Xi, additional, Choi, Yongsoo, additional, Cao, Hongmei, additional, Yu, Rui, additional, Sturdy, Megan, additional, Pegan, Scott, additional, Liu, Ying, additional, Wang, Li-Qin, additional, Mesecar, Andrew D., additional, Breemen, Richard B. Van, additional, Pezzuto, John M., additional, Fong, Harry H.S., additional, Chen, Ye-Gao, additional, and Zhang, Hong-Jie, additional

Published
2010
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33. British Herbal Compendium

Author

Fong, Harry H.S

Subjects
British Herbal Compendium, vol. 2 (Book) -- Bradley, Peter, Books -- Book reviews, Biological sciences, Health, Science and technology
Abstract

Peter Bradley. British Herbal Compendium, vol. II. British Herbal Medicine Association, Bournemouth (2006) (409pp.,£59.5, hardcover), ISBN: 978-0-903032-12-4 This is the second volume of a most valuable companion to the British [...]

Published
2008

38. Rourinoside and rouremin, antimalarial constituents from Rourea minor

Author

He, Zhen-Dan, primary, Ma, Cui-Ying, additional, Tan, Ghee Teng, additional, Sydara, Kongmany, additional, Tamez, Pamela, additional, Southavong, Bounhoong, additional, Bouamanivong, Somsanith, additional, Soejarto, D. Doel, additional, Pezzuto, John M., additional, Fong, Harry H.S., additional, and Zhang, Hong-Jie, additional

Published
2006
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39. GABAergic phthalide dimers fromAngelica sinensis (Oliv.) Diels

Author

Deng, Shixin, primary, Chen, Shao-Nong, additional, Lu, Jian, additional, Wang, Zaijie Jim, additional, Nikolic, Dejan, additional, Breemen, Richard B. van, additional, Santarsiero, Bernard D., additional, Mesecar, Andrew, additional, Fong, Harry H.S., additional, Farnsworth, Norman R., additional, and Pauli, Guido F., additional

Published
2006
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40. Bioactive constituents from roots of Bursera tonkinensis

Author

Jutiviboonsuk, Aranya, primary, Zhang, Hongjie, additional, Tan, Ghee Teng, additional, Ma, Cuiying, additional, Hung, Nguyen Van, additional, Cuong, Nguyen Manh, additional, Bunyapraphatsara, Nuntavan, additional, Soejarto, D. Doel, additional, and Fong, Harry H.S., additional

Published
2005
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