1. Impact of smoking on cardiovascular risk and premature ageing: Findings from the STANISLAS cohort
- Author
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Tripti Rastogi, Nicolas Girerd, Zohra Lamiral, Emmanuel Bresso, Erwan Bozec, Jean-Marc Boivin, Patrick Rossignol, Faiez Zannad, João Pedro Ferreira, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), The fourth examination of the STANISLAS study was sponsored by the Centre Hospitalier Régional Universitaire of Nancy (CHRU) and the French Ministry of Health (Programme Hospitalier de Recherche Clinique Inter‐régional 2013), by the Contrat de Plan Etat‐ Lorraine and 'Fonds Européen de Développement Régional' (FEDER Lorraine), and by a public grant overseen by the French National Research Agency (ANR) as part of the second 'Investissements d'Avenir' program FIGHT‐HF (reference: ANR‐15‐RHU‐0004) and by the French 'Projet investissement d'avenir' (PIA) project 'Lorraine Université d'Excellence' (reference ANR‐15‐IDEX‐04‐LUE)., ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), European Project, European Project: FEDER, BOZEC, Erwan, Combattre l'insuffisance cardiaque - - FIGHT-HF2015 - ANR-15-RHUS-0004 - RHUS - VALID, ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID, Contrat de Plan Etat Lorraine IT2MP - INCOMING, and Fonds Européens de Développement Régional - FEDER - INCOMING
- Subjects
Aging ,circulating protein profile ,premature ageing ,Carotid Intima Media Thickness ,STANISLAS cohort ,Smoking ,Pulse Wave Analysis ,Carotid Intima-Media Thickness ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Estimated Glomerular ,Humans ,Cardiology and Cardiovascular Medicine ,Biomarkers - Abstract
International audience; Background and aims: Smoking may lead to premature ageing, but the impact on the cardiovascular system and circulating proteins needs further investigation. In the present study, we aim to understand the impact of smoking on heart and vessels and circulating biomarkers of multiple domains including cardiovascular damage, premature ageing and cancer-related pathways.Methods: The STANISLAS Cohort is a longitudinal familial cohort with detailed cardiovascular examination and biomarker assessment. This study included all the participants enrolled in the fourth visit of the STANISLAS Cohort for whom information on smoking habits was available (n = 1696). We assessed pulse wave velocity, intima-media thickness, echocardiographic parameters and a total of 460 proteins to study the association of circulating plasma proteins with smoking status (never vs. past vs. current smoking) while adjusting for potential confounders.Results: Current smokers were approximately 18 years younger but had higher left ventricular mass index (LVMi) and similar pulse wave velocity (PWV), carotid intima media thickness (cIMT), frequency of hypertension, diabetes and carotid plaques compared to the much older never smokers. After multivariate selection, 25 proteins were independently associated with current or past smoking. Current smoking was strongly associated with higher levels of EDIL-3, CCL11, TNFSF13B, KIT, and lower levels of IL-12B and PLTP (p < 0.0001) while past smoking was associated with FGF-21, CHIT1, and lower levels of CXCL10, IL1RL2 and RAGE (p < 0.01).Conclusions: Current smoking is associated with signs of early onset of cardiovascular ageing and protein biomarkers that regulate inflammation, endothelial function, metabolism, oncological processes and apoptosis.
- Published
- 2022
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