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38 results on '"Fonda, Sergio"'

4. Predictive mechanisms in idiom comprehension

Author

Vespignani, Francesco, Canal, Paolo, Molinaro, Nicola, Fonda, Sergio, and Cacciari, Cristina

Subjects
Idioms -- Psychological aspects, Comprehension -- Research, Prediction (Psychology) -- Research, Health, Psychology and mental health
Published
2010

8. Optical and electrical recording of neural activity evoked by graded contrast visual stimulus

Author

Bulf Luca, Salvatori Giorgia, Rovati Luigi, and Fonda Sergio

Subjects
Medical technology, R855-855.5
Abstract

Abstract Background Brain activity has been investigated by several methods with different principles, notably optical ones. Each method may offer information on distinct physiological or pathological aspects of brain function. The ideal instrument to measure brain activity should include complementary techniques and integrate the resultant information. As a "low cost" approach towards this objective, we combined the well-grounded electroencephalography technique with the newer near infrared spectroscopy methods to investigate human visual function. Methods The article describes an embedded instrumentation combining a continuous-wave near-infrared spectroscopy system and an electroencephalography system to simultaneously monitor functional hemodynamics and electrical activity. Near infrared spectroscopy (NIRS) signal depends on the light absorption spectra of haemoglobin and measures the blood volume and blood oxygenation regulation supporting the neural activity. The NIRS and visual evoked potential (VEP) are concurrently acquired during steady state visual stimulation, at 8 Hz, with a b/w "windmill" pattern, in nine human subjects. The pattern contrast is varied (1%, 10%, 100%) according to a stimulation protocol. Results In this study, we present the measuring system; the results consist in concurrent recordings of hemodynamic changes and evoked potential responses emerging from different contrast levels of a patterned stimulus. The concentration of [HbO2] increases and [HHb] decreases after the onset of the stimulus. Their variation shows a clear relationship with the contrast value: large contrast produce huge difference in concentration, while low contrast provokes small concentration difference. This behaviour is similar to the already known relationship between VEP response amplitude and contrast. Conclusion The simultaneous recording and analysis of NIRS and VEP signals in humans during visual stimulation with a b/w pattern at variable contrast, demonstrates a strong linear correlation between hemodynamic changes and evoked potential amplitude. Furthermore both responses present a logarithmic profile with stimulus contrast.

Published
2007
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10. Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

Author

Saxena, Puneet, primary, Severi, Leda, additional, Santucci, Matteo, additional, Taddia, Laura, additional, Ferrari, Stefania, additional, Luciani, Rosaria, additional, Marverti, Gaetano, additional, Marraccini, Chiara, additional, Tondi, Donatella, additional, Mor, Marco, additional, Scalvini, Laura, additional, Vitiello, Simone, additional, Losi, Lorena, additional, Fonda, Sergio, additional, Pacifico, Salvatore, additional, Guerrini, Remo, additional, D’Arca, Domenico, additional, Ponterini, Glauco, additional, and Costi, Maria Paola, additional

Published
2018
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12. Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Author

Severi, Leda, primary, Losi, Lorena, additional, Fonda, Sergio, additional, Taddia, Laura, additional, Gozzi, Gaia, additional, Marverti, Gaetano, additional, Magni, Fulvio, additional, Chinello, Clizia, additional, Stella, Martina, additional, Sheouli, Jalid, additional, Braicu, Elena I., additional, Genovese, Filippo, additional, Lauriola, Angela, additional, Marraccini, Chiara, additional, Gualandi, Alessandra, additional, D'Arca, Domenico, additional, Ferrari, Stefania, additional, and Costi, Maria P., additional

Published
2018
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13. Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer

Author

Severi, L, Losi, L, Fonda, S, Taddia, L, Gozzi, G, Marverti, G, Magni, F, Chinello, C, Stella, M, Sheouli, J, Braicu, E, Genovese, F, Lauriola, A, Marraccini, C, Gualandi, A, D'Arca, D, Ferrari, S, Costi, M, Severi, Leda, Losi, Lorena, Fonda, Sergio, Taddia, Laura, Gozzi, Gaia, Marverti, Gaetano, Magni, Fulvio, Chinello, Clizia, Stella, Martina, Sheouli, Jalid, Braicu, Elena I., Genovese, Filippo, Lauriola, Angela, Marraccini, Chiara, Gualandi, Alessandra, D'Arca, Domenico, Ferrari, Stefania, Costi, Maria P., Severi, L, Losi, L, Fonda, S, Taddia, L, Gozzi, G, Marverti, G, Magni, F, Chinello, C, Stella, M, Sheouli, J, Braicu, E, Genovese, F, Lauriola, A, Marraccini, C, Gualandi, A, D'Arca, D, Ferrari, S, Costi, M, Severi, Leda, Losi, Lorena, Fonda, Sergio, Taddia, Laura, Gozzi, Gaia, Marverti, Gaetano, Magni, Fulvio, Chinello, Clizia, Stella, Martina, Sheouli, Jalid, Braicu, Elena I., Genovese, Filippo, Lauriola, Angela, Marraccini, Chiara, Gualandi, Alessandra, D'Arca, Domenico, Ferrari, Stefania, and Costi, Maria P.

Abstract

Proteomics and bioinformatics are a useful combined technology for the characterization of protein expression level and modulation associated with the response to a drug and with its mechanism of action. The folate pathway represents an important target in the anticancer drugs therapy. In the present study, a discovery proteomics approach was applied to tissue samples collected from ovarian cancer patients who relapsed after the first-line carboplatin-based chemotherapy and were treated with pemetrexed (PMX), a known folate pathway targeting drug. The aim of the work is to identify the proteomic profile that can be associated to the response to the PMX treatment in pre-treatement tissue. Statistical metrics of the experimental Mass Spectrometry (MS) data were combined with a knowledge-based approach that included bioinformatics and a literature review through ProteinQuest™ tool, to design a protein set of reference (PSR). The PSR provides feedback for the consistency of MS proteomic data because it includes known validated proteins. A panel of 24 proteins with levels that were significantly different in pre-treatment samples of patients who responded to the therapy vs. the non-responder ones, was identified. The differences of the identified proteins were explained for the patients with different outcomes and the known PMX targets were further validated. The protein panel herein identified is ready for further validation in retrospective clinical trials using a targeted proteomic approach. This study may have a general relevant impact on biomarker application for cancer patients therapy selection

Published
2018

24. Saccadic eye movements are impaired in Duchenne muscular dystrophy

Author

Lui, Fausta, Fonda, Sergio, Merlini, L., and Corazza, Ruggero

Subjects
muscular dystrophy, Adult, Male, Adolescent, saccades, Muscular Dystrophy, Duchenne, eye movements, Electrooculography, Ocular Motility Disorders, electrooculography (EOG), Saccades, Humans, Child
Abstract

Extraocular muscles are generally considered to be spared in Duchenne Muscular Dystrophy (DMD). However, this assumption is based mainly on clinical observations, as systematic eye movement recordings have been performed in a very limited number of cases. Our goal was to analyze several saccade parameters in a higher number of cases, in order to reveal a possible ocular-motor impairment in DMD. Data were collected from a population of 9 subjects with DMD and 9 healthy male subjects of comparable age as controls. We used the electrooculographic (EOG) technique coupled with advanced digital signal processing; saccade duration, amplitude, mean velocity, peak velocity and K factor (ratio mean/peak velocity) were measured. The DMD group showed saccades with significantly longer duration and lower velocity, with respect to controls; these differences were accounted for mainly by the largest movements, whereas there were no significant differences at the smallest eccentricity tested (3 deg). Neither amplitude nor K factor were significantly different from controls for any of the eccentricities tested. To our knowledge. this is the first study to suggest significant impairment of eye movements in Duchenne muscular dystrophy.

Published
2002

34. Relative Photometric Measurements of Retinal Circulation (Dromofluorograms): A Television Technique

Author

Fonda, Sergio and Bagolini, Bruno

Abstract

• Television fluoroangiography is used in order to obtain fluorescein dilution curves (dromofluorograms [From the Greek word: δ ρ ο μ ο, which means flowing. We coined this word because dilution curves do not afford a true measurement of the blood circulation, or simply of a dilution, but of the fluorescein transport in the circulation!]) from single retinal vessels. An optical fiber conveys the light from a single retinal artery, vein, or any other retinal area on the video screen to a photomultiplier. After lowpass electronic filtration, the dilution curves are recorded on a strip-chart recorder. The measurements considered are all related to time: the time interval between initial instants of the arterial and venous curve; the time interval between maximum instants; the arterial and venous curve rising times. It is seen that (1) the method is sensitive enough to enable variations in the quantities in pathologic cases to be detected; (2) owing to the great variability from part to part of the vessels, it is important to specify where the retinal dromofluorogram has been recorded.(Arch Ophthalmol 95:302-307, 1977)

Published
1977
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38. Clinical Evaluation of the ButterfLife Device for Simultaneous Multiparameter Telemonitoring in Hospital and Home Settings

Author

Francesco Salton, Stefano Kette, Paola Confalonieri, Sergio Fonda, Selene Lerda, Michael Hughes, Marco Confalonieri, Barbara Ruaro, Salton, Francesco, Kette, Stefano, Confalonieri, Paola, Fonda, Sergio, Lerda, Selene, Hughes, Michael, Confalonieri, Marco, and Ruaro, Barbara

Subjects
vital parameters, ButterfLife, ECG, artificial intelligence, photoplethysmography, telehealth, telemedicine, Clinical Biochemistry
Abstract

We conducted a two-phase study to test the reliability and usability of an all-in-one artificial intelligence-based device (ButterfLife), which allows simultaneous monitoring of five vital signs. The first phase of the study aimed to test the agreement between measurements performed with ButterfLife vs. standard of care (SoC) in 42 hospitalized patients affected by acute respiratory failure. In this setting, the greatest discordance between ButterfLife and SoC was in respiratory rate (mean difference −4.69 bpm). Significantly close correlations were observed for all parameters except diastolic blood pressure and oxygen saturation (Spearman’s Rho −0.18 mmHg; p = 0.33 and 0.20%; p = 0.24, respectively). The second phase of the study was conducted on eight poly-comorbid patients using ButterfLife at home, to evaluate the number of clinical conditions detected, as well as the patients’ compliance and satisfaction. The average proportion of performed tests compared with the scheduled number was 67.4%, and no patients reported difficulties with use. Seven conditions requiring medical attention were identified, with a sensitivity of 100% and specificity of 88.9%. The median patient satisfaction was 9.5/10. In conclusion, ButterfLife proved to be a reliable and easy-to-use device, capable of simultaneously assessing five vital signs in both hospital and home settings.

Published
2022
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