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6. Effects of a High-Fat Diet on Insulin-Related miRNAs in Plasma and Brain Tissue in APPSwe/PS1dE9 and Wild-Type C57BL/6J Mice

Author

Rojas-Criollo, Melina, primary, Novau-Ferré, Nil, additional, Gutierrez-Tordera, Laia, additional, Ettcheto, Miren, additional, Folch, Jaume, additional, Papandreou, Christopher, additional, Panisello, Laura, additional, Cano, Amanda, additional, Mostafa, Hamza, additional, Mateu-Fabregat, Javier, additional, Carrasco, Marina, additional, Camins, Antoni, additional, and Bulló, Mònica, additional

Published
2024
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11. Effects of a High-Fat Diet on Insulin-Related miRNAs in Plasma and Brain Tissue in APP Swe /PS1dE9 and Wild-Type C57BL/6J Mice.

Author

Rojas-Criollo, Melina, Novau-Ferré, Nil, Gutierrez-Tordera, Laia, Ettcheto, Miren, Folch, Jaume, Papandreou, Christopher, Panisello, Laura, Cano, Amanda, Mostafa, Hamza, Mateu-Fabregat, Javier, Carrasco, Marina, Camins, Antoni, and Bulló, Mònica

Abstract

Insulin resistance (IR)-related miRNAs have been associated with the development and progression of Alzheimer's disease (AD). The dietary modulation of these miRNAs could become a potential strategy to manage AD. The aim of this study was to evaluate the effect of a high-fat diet (HFD), which aggravates AD-related pathogenic processes, on serum, cortex and hippocampus IR-related miRNA expression. C57BL/6J WT and APPSwe/PS1dE9 mice were fed either an HFD or a conventional diet till 6 months of age. The mice fed with the HFD showed a significant increase in body weight and worsening glucose and insulin metabolism. miR-19a-3p was found to be up-regulated in the cortex, hippocampus and serum of APP/PS1 mice and in the serum and hippocampus of WT mice fed with the HFD. miR-34a-5p and miR-146a-5p were up-regulated in the serum of both groups of mice after consuming the HFD. Serum miR-29c-3p was overexpressed after consuming the HFD, along with hippocampal miR-338-3p and miR-125b-5p, only in WT mice. The HFD modulated the expression of peripheral and brain miRNAs related to glucose and insulin metabolism, suggesting the potential role of these miRNAs not only as therapeutic targets of AD but also as peripheral biomarkers for monitoring AD. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations

Author

Espinosa-Jiménez, Triana, primary, Busquets, Oriol, additional, Cano, Amanda, additional, Sánchez-López, Elena, additional, Verdaguer, Ester, additional, Parcerisas, Antoni, additional, Olloquequi, Jordi, additional, Auladell, Carme, additional, Folch, Jaume, additional, Wahli, Walter, additional, Vázquez-Carrera, Manuel, additional, Camins, Antoni, additional, and Ettcheto, Miren, additional

Published
2022
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28. Impact of New Drugs for Therapeutic Intervention in Alzheimer’s Disease

Author

Olloquequi, Jordi, primary, Ettcheto, Miren, primary, Cano, Amanda, primary, Sanchez-López, Elena, primary, Carrasco, Marina, primary, Espinosa, Triana, primary, Beas-Zarate, Carlos, primary, Gudiño-Cabrera, Graciela, primary, Ureña-Guerrero, Monica E., primary, Verdaguer, Ester, primary, Folch, Jaume, primary, Auladell, Carme, primary, and Camins, Antoni, primary

Published
2022
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29. Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders

Author

Olloquequi, Jordi, Cano, Amanda, Sanchez-López, Elena, Carrasco, Marina, Verdaguer, Ester, Fortuna, Ana, Folch, Jaume, Bulló, Mònica, Auladell, Carme, Camins, Antoni, Ettcheto, Miren, Olloquequi, Jordi, Cano, Amanda, Sanchez-López, Elena, Carrasco, Marina, Verdaguer, Ester, Fortuna, Ana, Folch, Jaume, Bulló, Mònica, Auladell, Carme, Camins, Antoni, and Ettcheto, Miren

Abstract

Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine kinases. This widely localized enzyme has been involved in the pathophysiology of several diseases. More recently, PTP1B has attracted attention in the field of neuroscience, since its activation in brain cells can lead to schizophrenia-like behaviour deficits, anxiety-like effects, neurodegeneration, neuroinflammation and depression. Conversely, PTP1B inhibition has been shown to prevent microglial activation, thus exerting a potent anti-inflammatory effect and has also shown potential to increase the cognitive process through the stimulation of hippocampal insulin, leptin and BDNF/TrkB receptors. Notwithstanding, most research on the clinical efficacy of targeting PTP1B has been developed in the field of obesity and type 2 diabetes mellitus (TD2M). However, despite the link existing between these metabolic alterations and neurodegeneration, no clinical trials assessing the neurological advantages of PTP1B inhibition have been performed yet. Preclinical studies, though, have provided strong evidence that targeting PTP1B could allow to reach different pathophysiological mechanisms at once. herefore, specific interventions or trials should be designed to modulate PTP1B activity in brain, since it is a promising strategy to decelerate or prevent neurodegeneration in aged individuals, among other neurological diseases. The present paper fails to include all neurological conditions in which PTP1B could have a role; instead, it focuses on those which have been related to metabolic alterations and neurodegenerative processes. Moreover, only preclinical data is discussed, since clinical studies on the potential of PTP1B inhibition for treating neurological diseases are still required.

Published
2022

30. JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function

Author

Universitat Rovira i Virgili, Busquets, Oriol; Espinosa-Jimenez, Triana; Ettcheto, Miren; Olloquequi, Jordi; Bullo, Monica; Carro, Eva; Cantero, Jose Luis; Casadesus, Gemma; Folch, Jaume; Verdaguer, Ester; Auladell, Carme; Camins, Antoni, Universitat Rovira i Virgili, and Busquets, Oriol; Espinosa-Jimenez, Triana; Ettcheto, Miren; Olloquequi, Jordi; Bullo, Monica; Carro, Eva; Cantero, Jose Luis; Casadesus, Gemma; Folch, Jaume; Verdaguer, Ester; Auladell, Carme; Camins, Antoni

Abstract

Background and aim The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we induced chronic metabolic stress by feeding of a high-fat diet (HFD) in order to study its consequences in cognition. We also studied the effects of a loss of function of isoforms 1 and 3 of the c-Jun N-terminal Kinases (JNK), stress and cell death response elements. Methods Animals were fed either with conventional chow or with HFD, from their weaning until their sacrifice at 9 months. Before sacrifice, body weight, intraperitoneal glucose and insulin tolerance test (IP-GTT and IP-ITT) were performed to evaluate peripheral biometrics. Additionally, cognitive behavioral tests and analysis of spine density were performed to assess cognitive function. Molecular studies were carried out to confirm the effects of metabolic stressors in the hippocampus relative to cognitive loss. Results Our studies demonstrated that HFD in Jnk3(-/-) lead to synergetic responses. Loss of function of JNK3 led to increased body weight, especially when exposed to an HFD and they had significantly decreased response to insulin. These mice also showed increased stress in the endoplasmic reticulum and diminished cognitive capacity. However, loss of function of JNK1 promoted normal or heightened energetic metabolism and preserved cognitive function even when chronically metabolically stressed. Conclusions Downregulation of JNK3 does not seem to be a suitable target for the modulation of energetic-cognitive dysregulations while loss of function of JNK1 seems to promote a good metabolic-cognitive profile, just like resistance to the negative effects of chronic feeding with HFD.

Published
2022

35. GSPE pre-treatment protects against long-term cafeteria diet-induced mitochondrial and inflammatory affectations in the hippocampus of rats

Author

Busquets, Oriol, primary, Carrasco, Marina, additional, Espinosa-Jiménez, Triana, additional, Ettcheto, Miren, additional, Verdaguer, Ester, additional, Auladell, Carme, additional, Bullò, Mònica, additional, Camins, Antoni, additional, Pinent, Montserrat, additional, Rodríguez-Gallego, Esther, additional, and Folch, Jaume, additional

Published
2021
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36. GSPE pre-treatment protects against long-term cafeteria diet-induced mitochondrial and inflammatory affectations in the hippocampus of rats.

Author

Busquets, Oriol, Carrasco, Marina, Espinosa-Jiménez, Triana, Ettcheto, Miren, Verdaguer, Ester, Auladell, Carme, Bullò, Mònica, Camins, Antoni, Pinent, Montserrat, Rodríguez-Gallego, Esther, and Folch, Jaume

Subjects
HIPPOCAMPUS (Brain), CAFETERIAS, INSULIN sensitivity, MITOCHONDRIA, DIETARY supplements, ASTROCYTES
Abstract

Deregulations like the loss of sensitivity to insulin (insulin resistance) and chronic inflammation are alterations very commonly found in sporadic forms of neurodegenerative pathologies. Thus, finding strategies to protect against them, may lead to a reduction in the incidence and/or affectation of these pathologies. The grape seed-derived proanthocyanidins extract (GSPE) is a mixture of compounds highly enriched in polyphenols and flavonoids that have shown to have a wide range of therapeutic benefits due to their antioxidant and anti-inflammatory properties. This study aimed to assess the protective effects of a short pre-treatment of GSPE in the hippocampus against a prolonged feeding with cafeteria diet. GSPE was administered for 10 days followed by 12 weeks of cafeteria diet. We analyzed transcriptional activity of genes and protein expression of key mediators of neurodegeneration in brain samples. Results indicated that GSPE was able to protect against cellular damage through the activation of AKT, as well as promote the maintenance of mitochondrial function by conserving the OXPHOS complexes and upregulating the antioxidant SOD. We observed that GSPE decreased inflammatory activation as observed through the downregulation of JNK, IL6 and TNFα, just like the reduction in reactive profile of astrocytes. Overall, the data presented here offers an interesting and hopeful initial step for future long-term studies on the beneficial effects of a supplementation of common diets with polyphenol and flavonoid substances for the amelioration of typical early hallmarks of neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

Author

Gutierrez, Laia, primary, Folch, Alexandre, additional, Rojas, Melina, additional, Cantero, José Luis, additional, Atienza, Mercedes, additional, Folch, Jaume, additional, Camins, Antoni, additional, Ruiz, Agustín, additional, Papandreou, Christopher, additional, and Bulló, Mònica, additional

Published
2021
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45. Pharmacological Strategies to Improve Dendritic Spines in Alzheimer’s Disease

Author

Ettcheto, Miren, primary, Busquets, Oriol, additional, Cano, Amanda, additional, Sánchez-Lopez, Elena, additional, Manzine, Patricia R., additional, Espinosa-Jimenez, Triana, additional, Verdaguer, Ester, additional, Sureda, Francesc X., additional, Olloquequi, Jordi, additional, Castro-Torres, Ruben D., additional, Auladell, Carme, additional, Folch, Jaume, additional, Casadesús, Gemma, additional, and Camins, Antoni, additional

Published
2021
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46. Additional file 1 of Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice

Author

Ettcheto, Miren, Sánchez-Lopez, Elena, Cano, Amanda, Carrasco, Marina, Herrera, Katherine, Manzine, Patricia R., Espinosa-Jimenez, Triana, Busquets, Oriol, Verdaguer, Ester, Olloquequi, Jordi, Auladell, Carme, Folch, Jaume, and Camins, Antoni

Abstract

Additional file 1: Fig. S1. Speed on the training day (no statistical differences were obtained).

Published
2021
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47. Microplastics levels, size, morphology and composition in marine water, sediments and sand beaches. Case study of Tarragona coast (western Mediterranean)

Author

Universitat Rovira i Virgili, Exposito, Nora; Rovira, Joaquim; Sierra, Jordi; Folch, Jaume; Schuhmacher, Marta, Universitat Rovira i Virgili, and Exposito, Nora; Rovira, Joaquim; Sierra, Jordi; Folch, Jaume; Schuhmacher, Marta

Abstract

Mediterranean Sea has been proposed as the sixth greatest accumulation zone for marine litter and the most affected regarding to microplastics (MPs). Tarragona (Catalonia, NE Spain) coastal region suffers high pressure due to urbanization, tourism, industrial harbour and petrochemical/plastic industries. The present study aims to quantify and characterize in size, morphology and composition the MPs present in sandy beaches, marine sediments, and surface seawaters of Tarragona coastal region. MPs mean abundance were 1.30 items/m(3) in surface seawaters, 32.4 items/kg in marine sediments, and 10.7 items/kg in sandy beaches. Polyester fibres were dominant MPs in bottom sediments and seawater meanwhile polyethylene and polypropylene fragments were the main MPs in beaches. The fibres balls associated with bottom sediments, organic matter and plankton were abundant, masking the real quantity of fibres in each reservoir. The abundance by volume of seawater MPs was higher to those found in oceanic areas and similar to other areas of Mediterranean Sea, corroborating that Western Mediterranean Sea as a region of MPs accumulation. MPs composition and abundance suggested the input of numerous land-base-sources, WWTP (wastewater treatment plants) effluents discharges, and emissaries as the most important. Marine MPs pollution were studied from an integrative point of view, that indudes superficial sea water, sand from beaches and sediments. The dynamics of MPs in Tarragona coast were characterized by seawater as the media that receive and facilitate dispersion and fragmentation. The shoreline acts as an intermediate reservoir with constant weathering and active exchange with seawater surface and the sediments acts as a significant sink for medium MPs sizes. It is necessary to develo

Published
2021

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