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Your search keyword '"Fokoue, Harold H."' showing total 8 results
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8 results on '"Fokoue, Harold H."'

1. Antileishmanial activity evaluation of a natural amide and its synthetic analogs against Leishmania (V.) braziliensis: an integrated approach in vitro and in silico

Author

da Silva, Minelly A., Fokoue, Harold H., Fialho, Saara N., dos Santos, Ana Paula de A., Rossi, Norton R. D. L. P., Gouveia, Aurileya de J., Ferreira, Amália S., Passarini, Guilherme M., Garay, Ana F. G., Alfonso, Jorge J., Soares, Andreimar M., Zanchi, Fernando B., Kato, Massuo J., Teles, Carolina B. G., and Kuehn, Christian C.

Published
2021
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8. Virtual Screening Techniques in Drug Discovery: Review and Recent Applications

Author

Rocha, Sheisi F.L. da Silva, Olanda, Carolina G., Fokoue, Harold H., and Sant'Anna, Carlos M.R.

Abstract

The discovery of bioactive molecules is an expensive and time-consuming process and new strategies are continuously searched for in order to optimize this process. Virtual Screening (VS) is one of the recent strategies that has been explored for the identification of candidate bioactive molecules. The number of new techniques and software that can be applied in this strategy has grown considerably in recent years, so, before their use, it is necessary to understand the basics an also the limitations behind each one to get the most out of them. It is also necessary to assess the real contributions of this strategy so that more significant progress can be made in the future. In this context, this review aims to discuss some important points related to VS, including the use of virtual ligand and biotarget libraries, structurebased and ligand-based VS techniques, as well as to present recent cases where this strategy was successfully applied.

Published
2019
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