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2. Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond

Author

Jennings, Susan V., Finnerty, Celeste C., Hobart, Jessica S., Martín-Martínez, Mercedes, Sinclair, Kristin A., Slee, Valerie M., Agopian, Julie, Akin, Cem, Álvarez-Twose, Ivan, Bonadonna, Patrizia, Bowman, Angela S., Brockow, Knut, Bumbea, Horia, de Haro, Claudia, Fok, Jie Shen, Hartmann, Karin, Hegmann, Nicole, Hermine, Olivier, Kalisiak, Monika, Katelaris, Constance H., Kurz, Jacqueline, Marcis, Patrizia, Mayne, David, Mendoza, David, Moussy, Alain, Mudretzkyj, Genija, Vaia, Nicoleta Nidelea, Niedoszytko, Marek, Elberink, Hanneke Oude, Orfao, Alberto, Radia, Deepti H., Rosenmeier, Sophie, Ribada, Eugenia, Schinhofen, Waltraud, Schwaab, Juliana, Siebenhaar, Frank, Triggiani, Massimo, Tripodo, Giuseppe, Velazquez, Rocio, Wielink, Yvon, Wimazal, Friedrich, Yigit, Timo, Zubrinich, Celia, and Valent, Peter

Published
2022
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6. An update on the use of antihistamines in managing chronic urticaria.

Author

Xiang, Yi-Kui, Fok, Jie Shen, Podder, Indrashis, Yücel, Muhammed Burak, Özkoca, Defne, Thomsen, Simon Francis, and Kocatürk, Emek

Subjects
ANTIHISTAMINES, URTICARIA, SKIN diseases, GENOMICS, MOLECULAR genetics
Abstract

Urticaria, a mast cell-mediated skin disease, manifests as acute or chronic, with the latter divided into spontaneous and inducible types and requires individualized management, including identifying triggers and comorbidities. Antihistamines, particularly the second generation group, form the mainstay of primary treatment plans consisting of dosage adjustments and/or in combination with other treatment modalities depending on underlying disease control. A literature search was conducted using 'antihistamines,' 'urticaria,' 'pharmacogenomics,' 'genomics,' 'biomarkers' and 'treatment response' as key words. In this review, we focus on the comprehensive understanding and application of antihistamines in managing adult and adolescent patients with chronic urticaria. Using antihistamines to treat urticaria is set to change significantly, focusing more on personalized medicine and identifying key biomarkers to enhance treatment response prediction. These changes aim to make treatments more specific and cost-effective by avoiding unnecessary tests. Applying new approaches in everyday clinical care faces challenges like proving the biomarkers' reliability, updating current guidelines, and incorporating individualized treatments into standard procedures. Efforts should now concentrate on finding easy-to-use biomarkers, improving access to pharmacogenomics, understanding why some patients are resistant to treatment, and creating more specific treatment options based on patient needs. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Epidemiology, Management, and Treatment Access of Hereditary Angioedema in the Asia Pacific Region: Outcomes From an International Survey

Author

Li, Philip H., primary, Pawankar, Ruby, additional, Thong, Bernard Yu-Hor, additional, Fok, Jie Shen, additional, Chantaphakul, Hiroshi, additional, Hide, Michihiro, additional, Jindal, Ankur Kumar, additional, Kang, Hye-Ryun, additional, Abdul Latiff, Amir Hamzah, additional, Lobo, Rommel Crisenio M., additional, Munkhbayarlakh, Sonomjamts, additional, Nguyen, Dinh Van, additional, Shyur, Shyh-Dar, additional, Zhi, Yuxiang, additional, and Maurer, Marcus, additional

Published
2022
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17. Total IgE as a Marker for Chronic Spontaneous Urticaria

Author

Altrichter, Sabine, primary, Fok, Jie Shen, additional, Jiao, Qingqing, additional, Kolkhir, Pavel, additional, Pyatilova, Polina, additional, Romero, Sherezade Moñino, additional, Scheffel, Jörg, additional, Siebenhaar, Frank, additional, Steinert, Carolin, additional, Terhorst-Molawi, Dorothea, additional, Xiang, Yi-Kui, additional, Church, Martin K, additional, and Maurer, Marcus, additional

Published
2021
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18. Diagnostic procedures & practices in drug allergy/hypersensitivity: a survey of 13 Asian countries

Author

Tang, Min-Moon, primary, Fok, Jie Shen, additional, Thong, Bernard Yu-Hor, additional, Yun, James, additional, Li, Philip Hei, additional, Kang, Hye-Ryun, additional, Thien, Francis, additional, Yamaguchi, Masao, additional, Lucas, Michaela, additional, Chang, Yoon-Seok, additional, Kim, Byung-Keun, additional, Nagao, Mizuho, additional, Rengganis, Iris, additional, Tsai, Yi-Giien, additional, Chung, Wen-Hung, additional, Rerkpattanapipat, Ticha, additional, Kamchaisatian, Wasu, additional, Leung, Ting Fan, additional, Ho, Joo-Yoon, additional, Zhang, Luo, additional, Latiff, Amir Hamzah Abdul, additional, Fujisawa, Takao, additional, Castells, Mariana C, additional, Demoly, Pascal, additional, Wang, Jiu Yao, additional, and Pawankar, Ruby, additional

Published
2020
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19. Drug hypersensitivity reactions in Asia: regional issues and challenges

Author

Thong, Bernard Yu-Hor, primary, Lucas, Michaela, additional, Kang, Hye-Ryun, additional, Chang, Yoon-Seok, additional, Li, Philip Hei, additional, Tang, Min Moon, additional, Yun, James, additional, Fok, Jie Shen, additional, Kim, Byung-Keun, additional, Nagao, Mizuho, additional, Rengganis, Iris, additional, Tsai, Yi-Giien, additional, Chung, Wen-Hung, additional, Yamaguchi, Masao, additional, Rerkpattanapipat, Ticha, additional, Kamchaisatian, Wasu, additional, Leung, Ting Fan, additional, Yoon, Ho Joo, additional, Zhang, Luo, additional, Latiff, Amir Hamzah Abdul, additional, Fujisawa, Takao, additional, Thien, Francis, additional, Castells, Mariana C., additional, Demoly, Pascal, additional, Wang, Jiu-Yao, additional, and Pawankar, Ruby, additional

Published
2020
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20. Buckwheat allergy in Australia

Author

Fok, Jie Shen, primary, Kette, Frank, additional, Smith, William B, additional, Smith, Anthony, additional, Ahmadie, Aida, additional, Heddle, Robert, additional, and Hissaria, Pravin, additional

Published
2019
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23. Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)

Author

Gracia, Ibon Eguiluz, primary, Rondón, Carmen, additional, Campo, Paloma, additional, Prieto, Ana, additional, Mayorga, Lina, additional, Galindo, Luisa, additional, Molina, Ana, additional, Blanca, Miguel, additional, Torres, Maria Jose, additional, Morikawa, Taiyo, additional, Fukuoka, Ayumi, additional, Matsushita, Kazufumi, additional, Fujieda, Shigeharu, additional, Yoshimoto, Tomohiro, additional, Iwasaki, Naruhito, additional, Smulders, Tamar, additional, Van Egmond, Danielle, additional, Van Drunen, Kees, additional, Van Der Schee, Marc, additional, Beule, Achim Georg, additional, Berings, Margot, additional, Jult, Anton, additional, Vermeulen, Hanne, additional, De Ruyck, Natalie, additional, Derycke, Lara, additional, Ucar, Hakan, additional, Ghekiere, Philip, additional, Temmerman, Robin, additional, Ellis, John, additional, Bachert, Claus, additional, Lambrecht, Bart, additional, Dullaers, Melissa, additional, Gevaert, Philippe, additional, Arasi, Stefania, additional, Perna, Serena, additional, Resch, Yvonne, additional, Lupinek, Christian, additional, Chen, Kuan-Wei, additional, Vrtala, Susanne, additional, Valenta, Rudolf, additional, Matricardi, Paolo Maria, additional, Gonçalves, Ivânia, additional, Jacinto, Tiago, additional, Amaral, Rita, additional, Pereira, Ana M., additional, Araújo, Luís M., additional, Couto, Mariana, additional, Fonseca, João A., additional, Stjarne, Par, additional, Kaulsay, Ranbir, additional, Pohl, Wolfgang, additional, Plaza, Maria Carmen, additional, Prieto, Ana Maria, additional, Mayorga, Cristobalina, additional, Herknerova, Magdalena, additional, Wang, Tengchin, additional, Wu, Chiejun, additional, Kilimajer, Jonathan, additional, Pujols, Laura, additional, Roca-Ferrer, Jordi, additional, Callejas, Borja, additional, Fuentes-Prado, Mireya, additional, Perez-Gonzalez, Maria, additional, Alobid, Isam, additional, Valero, Antonio, additional, Picado, Cesar, additional, Murray, Ruth, additional, Mullol, Joaquim, additional, Steelant, Brecht, additional, Martens, Katleen, additional, Boeckxstaens, Guy, additional, Seys, Sven F., additional, Hellings, Peter W., additional, Biggs, Timothy C., additional, Hayes, Stephen M., additional, Harries, Philip G., additional, Pender, Sylvia, additional, Salib, Rami J., additional, Kim, Jean, additional, Lee, Hyun Sil, additional, Kalogjera, Livije, additional, Vrkic, Nada, additional, Topic, Anita, additional, Tomljenovic, Dejan, additional, Greguric, Tomislav, additional, Radovanovic, Patricija Bankovic, additional, Jund, Rainer, additional, Haimerl, Pascal, additional, Chaker, Adam M., additional, Schober, Yvonne, additional, Schindela, Sonja, additional, Nockher, Andreas, additional, Schmidt-Weber, Carsten B., additional, Bieren, Julia Esser-Von, additional, Ickrath, Pascal, additional, Kleinsasser, Norbert, additional, Beyersdorf, Niklas, additional, Ding, Xin, additional, Hagen, Rudolf, additional, Hackenberg, Stephan, additional, Cangiano, Daniela, additional, Cinetto, Francesco, additional, Brescia, Giuseppe, additional, Marioni, Gino, additional, Zanotti, Claudia, additional, Schiavon, Franco, additional, Padoan, Roberto, additional, Caputo, Ilaria, additional, Neri, Raffaella, additional, Agostini, Carlo, additional, Kim, Ji Heui, additional, Jang, Yong Ju, additional, Lim, Ji Youn, additional, Kim, Sung Hee, additional, Savlevich, Elena, additional, Gaganov, Leonid, additional, Kochnova, Maria, additional, Egorov, Victor, additional, Fok, Jie Shen, additional, Hanif, Tanzeela, additional, Renkonen, Jutta, additional, Joenväärä, Sakari, additional, Kankainen, Matti, additional, Mäkelä, Mika, additional, Kauppi, Paula, additional, Pelkonen, Anna, additional, Mattila, Pirkko, additional, Renkonen, Risto, additional, Toppila-Salmi, Sanna, additional, Holtappels, Gabriele, additional, Lambrecht, Bart N., additional, Blanca-López, Natalia, additional, Gonzalez-Visiedo, Miguel, additional, Jurado, Raquel, additional, and Canto, Gabriela, additional

Published
2017
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28. Adverse drug reaction classification by health professionals: appropriate discrimination between allergy and intolerance?

Author

Gillian E. Caughey, William B Smith, Jie Shen Fok, Sepehr Shakib, Shakib, Sepehr, Caughey, Gillian E, Fok, Jie Shen, and Smith, William B

Subjects
Pulmonary and Respiratory Medicine, Drug, Allergy, medicine.medical_specialty, media_common.quotation_subject, Immunology, adverse drug reaction, Adverse drug reaction, Internal medicine, medicine, Immunology and Allergy, Health services research, Contraindication, media_common, Minimal risk, Health professionals, business.industry, Research, RC581-607, medicine.disease, allergy, health services research, Increased risk, Immunologic diseases. Allergy, business
Abstract

Background: The correct classification of an adverse drug reaction (ADR) as allergy (immunological) or intolerance(non-immunological) has important clinical implications. The aim of this study was to examine the ability of health professionals to discriminate between allergy and intolerance, classify the severity of the ADR and degree of contraindication. Methods: Health professionals were presented ten ‘real-life’ ADR scenarios using an online questionnaire and asked to: categorise the reaction as allergy or intolerance, rate the severity of the reaction and judge the level of contraindication of the causative drug. The number and proportion of responses were calculated for each of the cases presented and associations between classification of reaction type, severity and level of contraindication were examined. Results: A total of 394 responses were received. Overall 59.0% (SD 28.9) correctly categorised the cases, 60.8% (SD16.8) classified the severity correct, and less than half (44.7%, SD 28.6) correctly identified the level of contraindication.The proportion of health professionals correctly answering the type, severity and level of contraindication for the allergy case was significantly higher (p < 0.0001) by comparison to the intolerance cases (type: 56.6% ± 33.1; severity:57.3 ± 11.9; level of contraindication: 38.5 ± 19.9). Conclusions: Health professionals have suboptimal understanding of classification of ADRs. Strategies are required to strictly avoid re-exposure of patients to drugs which carry an increased risk of inducing a dangerous reaction, whilst minimising the avoidance of drugs which are of minimal risk or allowing the use of low-risk drugs where the benefits may be significant. Refereed/Peer-reviewed

Published
2019

29. Transplant induced food sensitization without allergy-mechanisms of tolerance

Author

Tim Chataway, Pravin Hissaria, Thanh-Thao Adriana Le, Jie Shen Fok, William B Smith, Preethi Eldi, Sherin Vareeckal Joseph, Le, Thanh Thao (Adriana), Fok, Jie Shen, Vareeckal-Joseph, Sherin, Eldi, Preethi, Chataway, Timothy, Smith, William, and Hissaria, Pravin

Subjects
Allergy, business.industry, food tolerance, Allergens, medicine.disease, allergy, surgical procedures, operative, Immunology, Immune Tolerance, Immunology and Allergy, Medicine, Humans, business, Food Hypersensitivity, Food sensitization
Abstract

Bone marrow transplantation may transfer the production of food-specific IgE to the recipient, but this may not be sufficient to cause allergy; we undertook detailed immunological workup in a strongly sensitized but nonallergic hematopoietic stem cell transplant recipient to elucidate the potential mechanisms of tolerance. Refereed/Peer-reviewed

Published
2020

30. Complete response to dupilumab in a patient with chronic spontaneous urticaria who did not tolerate omalizumab.

Author

Zhu C, Fok JS, Lin L, Su H, and Maurer M

Abstract

Competing Interests: Dr Maurer is or recently was a speaker and/or advisor for and/or has received research funding from Allakos, 10.13039/100002429Amgen, Aralez, 10.13039/100018748ArgenX, 10.13039/100004325AstraZeneca, 10.13039/100012431Celldex, Centogene, 10.13039/100008322CSL Behring, 10.13039/100016525FAES, 10.13039/100004328Genentech, GIInnovation, 10.13039/100004330GSK, Innate Pharma, 10.13039/501100004095Kyowa Kirin, 10.13039/501100023331Leo Pharma, 10.13039/100004312Lilly, Menarini, Moxie, 10.13039/100004336Novartis, 10.13039/100004319Pfizer, 10.13039/100004337Roche, Sanofi/Regeneron, Third Harmonic Bio, 10.13039/100011110UCB, and Uriach. Drs Zhu, Fok, Lin, and Su have no conflicts of interest to declare.

Published
2022
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31. Azathioprine hypersensitivity presenting as cardiogenic shock and Sweet's syndrome in a patient with microscopic polyangiitis.

Author

Turow A, Yong TY, Fok JS, and Li JY

Subjects
Aged, Antibodies, Antineutrophil Cytoplasmic blood, Female, Humans, Immunosuppressive Agents adverse effects, Intra-Aortic Balloon Pumping, Microscopic Polyangiitis complications, Microscopic Polyangiitis immunology, Shock, Cardiogenic therapy, Azathioprine adverse effects, Drug Hypersensitivity diagnosis, Drug Hypersensitivity etiology, Microscopic Polyangiitis drug therapy, Shock, Cardiogenic diagnosis, Shock, Cardiogenic etiology, Sweet Syndrome diagnosis, Sweet Syndrome etiology
Abstract

Azathioprine hypersensitivity is a clinical syndrome which may manifest from isolated fever and rash to multi-organ failure. This rare condition is usually self-limiting following the discontinuation of azathioprine. Therefore, it is important to maintain a high index of clinical suspicion for hypersensitivity reactions with azathioprine therapy. We report a case of azathioprine hypersensitivity in a 69-year-old woman who developed cardiogenic shock and Sweet's syndrome following the initiation of azathioprine for her underlying autoantibodies to neutrophil cytoplasmic antigens (ANCA) associated microscopic polyangiitis.

Published
2012
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