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1. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author: Sartelli, M, Labricciosa, F, Coccolini, F, Coimbra, R, Abu-Zidan, F, Ansaloni, L, Al-Hasan, M, Ansari, S, Barie, P, Cainzos, M, Ceresoli, M, Chiarugi, M, Claridge, J, Cicuttin, E, Dellinger, E, Fry, D, Guirao, X, Hardcastle, T, Hecker, A, Leppaniemi, A, Litvin, A, Marwah, S, Maseda, E, Mazuski, J, Memish, Z, Kirkpatrick, A, Pagani, L, Podda, M, Rasa, H, Sakakushev, B, Sawyer, R, Tumietto, F, Xiao, Y, Aboubreeg, W, Adamou, H, Akhmeteli, L, Akin, E, Alberio, M, Alconchel, F, Magagi, I, Arauz, A, Argenio, G, Atanasov, B, Atici, S, Awad, S, Baili, E, Bains, L, Bala, M, Baraket, O, Baral, S, Belskii, V, Benboubker, M, Ben-Ishay, O, Bordoni, P, Boumediene, A, Brisinda, G, Cavazzuti, L, Chandy, S, Chiarello, M, Cillara, N, Clarizia, G, Cocuz, M, Cocuz, I, Conti, L, Coppola, R, Cui, Y, Czepiel, J, D'Acapito, F, Damaskos, D, Das, K, De Simone, B, Delibegovic, S, Demetrashvili, Z, Detanac, D, Dhingra, S, Di Bella, S, Dimitrov, E, Dogjani, A, D'Oria, M, Dumitru, I, Elmangory, M, Enciu, O, Fantoni, M, Filipescu, D, Fleres, F, Foghetti, D, Fransvea, P, Gachabayov, M, Galeiras, R, Gattuso, G, Ghannam, W, Ghisetti, V, Giraudo, G, Gonfa, K, Gonullu, E, Hamad, Y, Hecker, M, Isik, A, Ismail, N, Ismail, A, Jain, S, Kanj, S, Kapoor, G, Karaiskos, I, Kavalakat, A, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kim, J, Kobe, Y, Kok, K, Kovacevic, B, Kryvoruchko, I, Kuriyama, A, Landaluce-Olavarria, A, Lasithiotakis, K, Lohsiriwat, V, Lostoridis, E, Luppi, D, Vega, G, Maegele, M, Marinis, A, Martines, G, Martinez-Perez, A, Massalou, D, Mesina, C, Metan, G, Miranda-Novales, M, Mishra, S, Mohamed, M, Mohamedahmed, A, Mora-Guzman, I, Mulita, F, Musina, A, Navsaria, P, Negoi, I, Nita, G, O'Connor, D, Ordonez, C, Pantalone, D, Panyko, A, Papadopoulos, A, Pararas, N, Pata, F, Patel, T, Pellino, G, Perra, T, Perrone, G, Pesce, A, Pintar, T, Popivanov, G, Porcu, A, Quiodettis, M, Rahim, R, Mitul, A, Reichert, M, Rems, M, Campbell, G, Rocha-Pereira, N, Rodrigues, G, Villamil, G, Rossi, S, Sall, I, Kafil, H, Sasia, D, Seni, J, Seretis, C, Serradilla-Martin, M, Shelat, V, Siribumrungwong, B, Slavchev, M, Solaini, L, Tan, B, Tarasconi, A, Tartaglia, D, Toma, E, Tomadze, G, Toro, A, Tovani-Palone, M, van Goor, H, Vasilescu, A, Vereczkei, A, Veroux, M, Weckmann, S, Widmer, L, Yahya, A, Zachariah, S, Zakaria, A, Zubareva, N, Zuidema, W, Di Carlo, I, Cortese, F, Baiocchi, G, Maier, R, Catena, F, Sartelli M., Labricciosa F. M., Coccolini F., Coimbra R., Abu-Zidan F. M., Ansaloni L., Al-Hasan M. N., Ansari S., Barie P. S., Cainzos M. A., Ceresoli M., Chiarugi M., Claridge J. A., Cicuttin E., Dellinger E. P., Fry D. E., Guirao X., Hardcastle T. C., Hecker A., Leppaniemi A. K., Litvin A., Marwah S., Maseda E., Mazuski J. E., Memish Z. A., Kirkpatrick A. W., Pagani L., Podda M., Rasa H. K., Sakakushev B. E., Sawyer R. G., Tumietto F., Xiao Y., Aboubreeg W. F., Adamou H., Akhmeteli L., Akin E., Alberio M. G., Alconchel F., Magagi I. A., Arauz A. B., Argenio G., Atanasov B. C., Atici S. D., Awad S. S., Baili E., Bains L., Bala M., Baraket O., Baral S., Belskii V. A., Benboubker M., Ben-Ishay O., Bordoni P., Boumediene A., Brisinda G., Cavazzuti L., Chandy S. J., Chiarello M. M., Cillara N., Clarizia G., Cocuz M. -E., Cocuz I. G., Conti L., Coppola R., Cui Y., Czepiel J., D'Acapito F., Damaskos D., Das K., De Simone B., Delibegovic S., Demetrashvili Z., Detanac D. S., Dhingra S., Di Bella S., Dimitrov E. N., Dogjani A., D'Oria M., Dumitru I. M., Elmangory M. M., Enciu O., Fantoni M., Filipescu D., Fleres F., Foghetti D., Fransvea P., Gachabayov M., Galeiras R., Gattuso G., Ghannam W. M., Ghisetti V., Giraudo G., Gonfa K. B., Gonullu E., Hamad Y. T. E. Y., Hecker M., Isik A., Ismail N., Ismail A., Jain S. A., Kanj S. S., Kapoor G., Karaiskos I., Kavalakat A. J., Kenig J., Khamis F., Khokha V., Kiguba R., Kim J. I., Kobe Y., Kok K. Y. Y., Kovacevic B. M., Kryvoruchko I. A., Kuriyama A., Landaluce-Olavarria A., Lasithiotakis K., Lohsiriwat V., Lostoridis E., Luppi D., Vega G. M. M., Maegele M., Marinis A., Martines G., Martinez-Perez A., Massalou D., Mesina C., Metan G., Miranda-Novales M. G., Mishra S. K., Mohamed M. I. H., Mohamedahmed A. Y. Y., Mora-Guzman I., Mulita F., Musina A. -M., Navsaria P. H., Negoi I., Nita G. E., O'Connor D. B., Ordonez C. A., Pantalone D., Panyko A., Papadopoulos A., Pararas N., Pata F., Patel T., Pellino G., Perra T., Perrone G., Pesce A., Pintar T., Popivanov G. I., Porcu A., Quiodettis M. A., Rahim R., Mitul A. R., Reichert M., Rems M., Campbell G. Y. R., Rocha-Pereira N., Rodrigues G., Villamil G. E. R., Rossi S., Sall I., Kafil H. S., Sasia D., Seni J., Seretis C., Serradilla-Martin M., Shelat V. G., Siribumrungwong B., Slavchev M., Solaini L., Tan B. K., Tarasconi A., Tartaglia D., Toma E. A., Tomadze G., Toro A., Tovani-Palone M. R., van Goor H., Vasilescu A., Vereczkei A., Veroux M., Weckmann S. A., Widmer L. W., Yahya A. I., Zachariah S. K., Zakaria A. D., Zubareva N., Zuidema W. P., Di Carlo I., Cortese F., Baiocchi G. L., Maier R. V., Catena F., Sartelli, M, Labricciosa, F, Coccolini, F, Coimbra, R, Abu-Zidan, F, Ansaloni, L, Al-Hasan, M, Ansari, S, Barie, P, Cainzos, M, Ceresoli, M, Chiarugi, M, Claridge, J, Cicuttin, E, Dellinger, E, Fry, D, Guirao, X, Hardcastle, T, Hecker, A, Leppaniemi, A, Litvin, A, Marwah, S, Maseda, E, Mazuski, J, Memish, Z, Kirkpatrick, A, Pagani, L, Podda, M, Rasa, H, Sakakushev, B, Sawyer, R, Tumietto, F, Xiao, Y, Aboubreeg, W, Adamou, H, Akhmeteli, L, Akin, E, Alberio, M, Alconchel, F, Magagi, I, Arauz, A, Argenio, G, Atanasov, B, Atici, S, Awad, S, Baili, E, Bains, L, Bala, M, Baraket, O, Baral, S, Belskii, V, Benboubker, M, Ben-Ishay, O, Bordoni, P, Boumediene, A, Brisinda, G, Cavazzuti, L, Chandy, S, Chiarello, M, Cillara, N, Clarizia, G, Cocuz, M, Cocuz, I, Conti, L, Coppola, R, Cui, Y, Czepiel, J, D'Acapito, F, Damaskos, D, Das, K, De Simone, B, Delibegovic, S, Demetrashvili, Z, Detanac, D, Dhingra, S, Di Bella, S, Dimitrov, E, Dogjani, A, D'Oria, M, Dumitru, I, Elmangory, M, Enciu, O, Fantoni, M, Filipescu, D, Fleres, F, Foghetti, D, Fransvea, P, Gachabayov, M, Galeiras, R, Gattuso, G, Ghannam, W, Ghisetti, V, Giraudo, G, Gonfa, K, Gonullu, E, Hamad, Y, Hecker, M, Isik, A, Ismail, N, Ismail, A, Jain, S, Kanj, S, Kapoor, G, Karaiskos, I, Kavalakat, A, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kim, J, Kobe, Y, Kok, K, Kovacevic, B, Kryvoruchko, I, Kuriyama, A, Landaluce-Olavarria, A, Lasithiotakis, K, Lohsiriwat, V, Lostoridis, E, Luppi, D, Vega, G, Maegele, M, Marinis, A, Martines, G, Martinez-Perez, A, Massalou, D, Mesina, C, Metan, G, Miranda-Novales, M, Mishra, S, Mohamed, M, Mohamedahmed, A, Mora-Guzman, I, Mulita, F, Musina, A, Navsaria, P, Negoi, I, Nita, G, O'Connor, D, Ordonez, C, Pantalone, D, Panyko, A, Papadopoulos, A, Pararas, N, Pata, F, Patel, T, Pellino, G, Perra, T, Perrone, G, Pesce, A, Pintar, T, Popivanov, G, Porcu, A, Quiodettis, M, Rahim, R, Mitul, A, Reichert, M, Rems, M, Campbell, G, Rocha-Pereira, N, Rodrigues, G, Villamil, G, Rossi, S, Sall, I, Kafil, H, Sasia, D, Seni, J, Seretis, C, Serradilla-Martin, M, Shelat, V, Siribumrungwong, B, Slavchev, M, Solaini, L, Tan, B, Tarasconi, A, Tartaglia, D, Toma, E, Tomadze, G, Toro, A, Tovani-Palone, M, van Goor, H, Vasilescu, A, Vereczkei, A, Veroux, M, Weckmann, S, Widmer, L, Yahya, A, Zachariah, S, Zakaria, A, Zubareva, N, Zuidema, W, Di Carlo, I, Cortese, F, Baiocchi, G, Maier, R, Catena, F, Sartelli M., Labricciosa F. M., Coccolini F., Coimbra R., Abu-Zidan F. M., Ansaloni L., Al-Hasan M. N., Ansari S., Barie P. S., Cainzos M. A., Ceresoli M., Chiarugi M., Claridge J. A., Cicuttin E., Dellinger E. P., Fry D. E., Guirao X., Hardcastle T. C., Hecker A., Leppaniemi A. K., Litvin A., Marwah S., Maseda E., Mazuski J. E., Memish Z. A., Kirkpatrick A. W., Pagani L., Podda M., Rasa H. K., Sakakushev B. E., Sawyer R. G., Tumietto F., Xiao Y., Aboubreeg W. F., Adamou H., Akhmeteli L., Akin E., Alberio M. G., Alconchel F., Magagi I. A., Arauz A. B., Argenio G., Atanasov B. C., Atici S. D., Awad S. S., Baili E., Bains L., Bala M., Baraket O., Baral S., Belskii V. A., Benboubker M., Ben-Ishay O., Bordoni P., Boumediene A., Brisinda G., Cavazzuti L., Chandy S. J., Chiarello M. M., Cillara N., Clarizia G., Cocuz M. -E., Cocuz I. G., Conti L., Coppola R., Cui Y., Czepiel J., D'Acapito F., Damaskos D., Das K., De Simone B., Delibegovic S., Demetrashvili Z., Detanac D. S., Dhingra S., Di Bella S., Dimitrov E. N., Dogjani A., D'Oria M., Dumitru I. M., Elmangory M. M., Enciu O., Fantoni M., Filipescu D., Fleres F., Foghetti D., Fransvea P., Gachabayov M., Galeiras R., Gattuso G., Ghannam W. M., Ghisetti V., Giraudo G., Gonfa K. B., Gonullu E., Hamad Y. T. E. Y., Hecker M., Isik A., Ismail N., Ismail A., Jain S. A., Kanj S. S., Kapoor G., Karaiskos I., Kavalakat A. J., Kenig J., Khamis F., Khokha V., Kiguba R., Kim J. I., Kobe Y., Kok K. Y. Y., Kovacevic B. M., Kryvoruchko I. A., Kuriyama A., Landaluce-Olavarria A., Lasithiotakis K., Lohsiriwat V., Lostoridis E., Luppi D., Vega G. M. M., Maegele M., Marinis A., Martines G., Martinez-Perez A., Massalou D., Mesina C., Metan G., Miranda-Novales M. G., Mishra S. K., Mohamed M. I. H., Mohamedahmed A. Y. Y., Mora-Guzman I., Mulita F., Musina A. -M., Navsaria P. H., Negoi I., Nita G. E., O'Connor D. B., Ordonez C. A., Pantalone D., Panyko A., Papadopoulos A., Pararas N., Pata F., Patel T., Pellino G., Perra T., Perrone G., Pesce A., Pintar T., Popivanov G. I., Porcu A., Quiodettis M. A., Rahim R., Mitul A. R., Reichert M., Rems M., Campbell G. Y. R., Rocha-Pereira N., Rodrigues G., Villamil G. E. R., Rossi S., Sall I., Kafil H. S., Sasia D., Seni J., Seretis C., Serradilla-Martin M., Shelat V. G., Siribumrungwong B., Slavchev M., Solaini L., Tan B. K., Tarasconi A., Tartaglia D., Toma E. A., Tomadze G., Toro A., Tovani-Palone M. R., van Goor H., Vasilescu A., Vereczkei A., Veroux M., Weckmann S. A., Widmer L. W., Yahya A. I., Zachariah S. K., Zakaria A. D., Zubareva N., Zuidema W. P., Di Carlo I., Cortese F., Baiocchi G. L., Maier R. V., and Catena F.
Abstract: Background: The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants’ perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness. Methods: A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days. Results: Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for
Published: 2022

2. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Author: Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, Oldani, A, Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, Oldani, A, Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., and Oldani A.
Abstract: Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p < 0.001). The following determinants increased the likelihood of complication occurrence: undergoing surgery during 2020 (+ 67%), the increase of a unit in the AAST score (+ 26%), surgery performed > 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registrat
Published: 2021

3. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Author: Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A., Podda, M., Botteri, E., Passera, R., Agresta, F., Arezzo, A., Guerrieri, M., Ortenzi, M., Cavallo, F., Zese, M., Prando, D., Restini, E., Cianci, P., Millo, P., Brachet Contul, R., Serrao, A., Abatini, F., Altomare, D. F., Picciariello, A., Chetta, G., Lattanzio, F., Tonini, V., Gori, A., Jovine, E., Mastrangelo, L., Sartarelli, L., Frena, A., Malpaga, A., Bertelli, F., Pignata, G., Andreuccetti, J., Sanna, S., Lares, B., Sechi, R., Cillara, N., Pisanu, A., Delogu, D., Ciaccio, G., Farulla, M., Casati, M., Laface, L., De Luca, M., Russello, D., Latteri, S., Longoni, M., Masci, E., Vigna, S., Campanile, F. C., Foti, N., Lepiane, P., Balla, A., Cantore, F., Raveglia, V., Borghi, F., Giraudo, G., Verzelli, A., Budassi, A., Patriti, A., Foghetti, D., Montin, U., Amadio, L., Anania, G., Bombardini, C., Fabbri, N., Feo, C., Cianchi, F., Manetti, A., Lucchese, M., Soricelli, E., Ceccarelli, G., Patiti, M., Frascio, M., Stabilini, C., Filauro, M., Barberis, A., Troian, M., Nagliati, C., Campagnacci, R., Maurizi, A., Berti, S., Gennai, A., Marvaso, A., D'Antonio, D., Feo, C. V., Mazzola, L., Selvaggi, F., Carini, S., Costanzo, F., Boccia, L., Pascariello, A., Perrotta, N., Celiento, M., Opocher, E., Giovenzana, M., Stella, M., Ferrara, F., Boni, L., Abate, E., Da Lio, C., Valli, V., Gelmini, R., Serra, F., Piccoli, M., Gozzo, D., Gattolin, A., Sasia, D., Balani, A., Petronio, B., Calo, P. G., Canu, G. L., Contarini, E., Piatto, G., Vettoretto, N., Caprioli, M., Braga, M., Chiappetta, M. F., Maida, P., Tammaro, P., De Palma, G., Milone, M., Bottino, V., Canfora, A., Bagaglini, G., Agrusa, A., Barone, M., Mirabella, A., Marino, M. V., Gulotta, G., Romano, G., Sorrentino, M., Ferfoglia, S., Papagni, V., Eramo, S., Boselli, C., Basti, M., Caracino, V., Moretto, G., Inama, M., Capelli, P., Conti, L., Muratore, A., Cuoghi, M. M., Zerbinati, A., Corso, S., Vasino, M. C., Montuori, M., Fidanza, F., Lucchetta, A., Giuliani, A., Dinatale, G., Zanzi, F., Guariniello, A., Bonilauri, S., Frazzetta, G., Garino, M., Marafante, C., Gioffre, A., Del Monte, S. R., Sganga, G., Fransvea, P., Grande, M., Siragusa, L., Sica, G., Paola, M., Passantino, D. G., Catani, M., Ricci, F., Lauro, E., Facci, E., Parini, D., Armellino, M. F., Argenio, G., Porcu, A., Perra, T., Bordoni, P., Fleres, F., Parisi, A., Rossi, S., Saracco, R., Bono, D., Viora, T., Orlando, F., Ferrero, A., Fontana, A. P., De Paolis, P., Visconti, D., Quaglino, F., Festa, F., Palagi, S., Lo Secco, G., Morino, M., Allaix, M. E., Salzano, A., Tirone, G., Motter, M., Zanus, G., Passuello, N., Massani, M., Tutino, R., Manzini, N., Terranova, S., Merenda, R., Nordio, S., Zonta, S., Lovisetto, F., Guglielmi, A., Campagnaro, T., Amedeo, E., Scollica, M., Amodio, P., Giannotti, D., Olmi, S., Oldani, A., Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D.F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F.C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C.V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P.G., Canu G.L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M.F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M.V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M.M., Zerbinati A., Corso S., Vasino M.C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S.R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D.G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M.F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A.P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M.E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, Alberto, Podda, Mauro, Botteri, Emanuele, Passera, Roberto, Agresta, Ferdinando, Arezzo, Alberto, M Guerrieri, M Ortenzi, F Cavallo, M Zese, D Prando, E Restini, P Cianci, P Millo, R Brachet Contul, A Serrao, F Abatini, D F Altomare, A Picciariello, G Chetta, F Lattanzio, V Tonini, A Gori, E Jovine, L Mastrangelo, L Sartarelli, A Frena, A Malpaga, F Bertelli, G Pignata, J Andreuccetti, S Sanna, B Lares, R Sechi, N Cillara, A Pisanu, D Delogu, G Ciaccio, M Farulla, M Casati, L Laface, M De Luca, D Russello, S Latteri, M Longoni, E Masci, S Vigna, F C Campanile, N Foti, P Lepiane, A Balla, F Cantore, V Raveglia, F Borghi, G Giraudo, A Verzelli, A Budassi, A Patriti, D Foghetti, U Montin, L Amadio, G Anania, C Bombardini, Niccolò Fabbri, Carlo Feo, F Cianchi, A Manetti, M Lucchese, E Soricelli, G Ceccarelli, M Patiti, M Frascio, C Stabilini, M Filauro, A Barberis, M Troian, C Nagliati, R Campagnacci, A Maurizi, S Berti, A Gennai, A Marvaso, D D'Antonio, C V Feo, N Fabbri, L Mazzola, F Selvaggi, S Carini, F Costanzo, L Boccia, A Pascariello, N Perrotta, M Celiento, E Opocher, M Giovenzana, M Stella, F Ferrara, L Boni, E Abate, C Da Lio, V Valli, R Gelmini, F Serra, M Piccoli, D Gozzo, A Gattolin, D Sasia, A Balani, B Petronio, P G Calò, G L Canu, E Contarini, G Piatto, N Vettoretto, M Caprioli, M Braga, M F Chiappetta, P Maida, P Tammaro, G De Palma, M Milone, V Bottino, A Canfora, F Selvaggi, G Bagaglini, A Agrusa, M Barone, A Mirabella, M V Marino, G Gulotta, G Romano, M Sorrentino, S Ferfoglia, V Papagni, S Eramo, C Boselli, M Basti, V Caracino, G Moretto, M Inama, P Capelli, L Conti, A Muratore, M M Cuoghi, A Zerbinati, S Corso, M C Vasino, M Montuori, F Fidanza, A Lucchetta, A Giuliani, G Dinatale, F Zanzi, A Guariniello, S Bonilauri, G Frazzetta, M Garino, C Marafante, A Gioffrè, S R Del Monte, G Sganga, P Fransvea, M Grande, L Siragusa, G Sica, M Paola, D G Passantino, Marco Catani, F Ricci, E Lauro, E Facci, D Parini, M F Armellino, G Argenio, A Porcu, T Perra, P Bordoni, F Fleres, A Parisi, S Rossi, R Saracco, D Bono, T Viora, F Orlando, A Ferrero, A P Fontana, P De Paolis, D Visconti, F Quaglino, F Festa, S Palagi, G Lo Secco, M Morino, M E Allaix, A Salzano, G Tirone, M Motter, G Zanus, N Passuello, M Massani, R Tutino, N Manzini, S Terranova, R Merenda, S Nordio, S Zonta, F Lovisetto, A Guglielmi, T Campagnaro, E Amedeo, M Scollica, P Amodio, D Giannotti, S Olmi, A Oldani, Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, and Oldani, A
Subjects: medicine.medical_specialty, COVID-19 Pandemic, Coronavirus disease 2019 (COVID-19), Endoscopic surgery, NO, Appendectomy, Appendicitis, Machine learning, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Retrospective Studie, Pandemic, medicine, Humans, Appendiciti, Laparoscopy, Pandemics, Retrospective Studies, medicine.diagnostic_test, business.industry, COVID-19 Pandemic, Appendicitis, Appendicectomy, Machine learning, SARS-CoV-2, COVID-19, Length of Stay, medicine.disease, Settore MED/18, Surgery, Italy, 030220 oncology & carcinogenesis, appendicitis, COVID-19 pandemic, machine learning, appendectomy, cohort studies, humans, length of stay, pandemics, postoperative complications, retrospective studies, laparoscopy, 030211 gastroenterology & hepatology, Observational study, Original Article, Postoperative Complication, Appendicectomy, Cohort Studie, business, Complication, Cohort study, Human
Abstract: Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020
Published: 2021

4. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

Author: Sartelli, M., Labricciosa, F.M., Coccolini, F., Coimbra, R., Abu-Zidan, F.M., Ansaloni, L., Al-Hasan, M.N., Ansari, S., Barie, P.S., Caínzos, M.A., Ceresoli, M., Chiarugi, M., Claridge, J.A., Cicuttin, E., Dellinger, E.P., Fry, D.E., Guirao, X., Hardcastle, T.C., Hecker, A., Leppäniemi, A.K., Litvin, A., Marwah, S., Maseda, E., Mazuski, J.E., Memish, Z.A., Kirkpatrick, A.W., Pagani, L., Podda, M., Rasa, H.K., Sakakushev, B.E., Sawyer, R.G., Tumietto, F., Xiao, Y., Aboubreeg, W.F., Adamou, H., Akhmeteli, L., Akin, E., Alberio, M.G., Alconchel, F., Magagi, I.A., Araúz, A.B., Argenio, G., Atanasov, B.C., Atici, S.D., Awad, S.S., Baili, E., Bains, L., Bala, M., Baraket, O., Baral, S., Belskii, V.A., Benboubker, M., Ben-Ishay, O., Bordoni, P., Boumédiène, A., Brisinda, G., Cavazzuti, L., Chandy, S.J., Chiarello, M.M., Cillara, N., Clarizia, G., Cocuz, M.E., Cocuz, I.G., Conti, L., Coppola, R., Cui, Y., Czepiel, J., D'Acapito, F., Damaskos, D., Das, K., Simone, B. De, Delibegovic, S., Demetrashvili, Z., Detanac, D.S., Dhingra, S., Bella, S. Di, Dimitrov, E.N., Dogjani, A., D'Oria, M., Dumitru, I.M., Elmangory, M.M., Enciu, O., Fantoni, M., Filipescu, D., Fleres, F., Foghetti, D., Fransvea, P., Gachabayov, M., Galeiras, R., Gattuso, G., Ghannam, W.M., Ghisetti, V., Giraudo, G., Gonfa, K.B., Gonullu, E., Hamad, Y., Hecker, M., Isik, A., Ismail, N., Ismail, A., Goor, H. van, Maier, R.V., Catena, F., Sartelli, M., Labricciosa, F.M., Coccolini, F., Coimbra, R., Abu-Zidan, F.M., Ansaloni, L., Al-Hasan, M.N., Ansari, S., Barie, P.S., Caínzos, M.A., Ceresoli, M., Chiarugi, M., Claridge, J.A., Cicuttin, E., Dellinger, E.P., Fry, D.E., Guirao, X., Hardcastle, T.C., Hecker, A., Leppäniemi, A.K., Litvin, A., Marwah, S., Maseda, E., Mazuski, J.E., Memish, Z.A., Kirkpatrick, A.W., Pagani, L., Podda, M., Rasa, H.K., Sakakushev, B.E., Sawyer, R.G., Tumietto, F., Xiao, Y., Aboubreeg, W.F., Adamou, H., Akhmeteli, L., Akin, E., Alberio, M.G., Alconchel, F., Magagi, I.A., Araúz, A.B., Argenio, G., Atanasov, B.C., Atici, S.D., Awad, S.S., Baili, E., Bains, L., Bala, M., Baraket, O., Baral, S., Belskii, V.A., Benboubker, M., Ben-Ishay, O., Bordoni, P., Boumédiène, A., Brisinda, G., Cavazzuti, L., Chandy, S.J., Chiarello, M.M., Cillara, N., Clarizia, G., Cocuz, M.E., Cocuz, I.G., Conti, L., Coppola, R., Cui, Y., Czepiel, J., D'Acapito, F., Damaskos, D., Das, K., Simone, B. De, Delibegovic, S., Demetrashvili, Z., Detanac, D.S., Dhingra, S., Bella, S. Di, Dimitrov, E.N., Dogjani, A., D'Oria, M., Dumitru, I.M., Elmangory, M.M., Enciu, O., Fantoni, M., Filipescu, D., Fleres, F., Foghetti, D., Fransvea, P., Gachabayov, M., Galeiras, R., Gattuso, G., Ghannam, W.M., Ghisetti, V., Giraudo, G., Gonfa, K.B., Gonullu, E., Hamad, Y., Hecker, M., Isik, A., Ismail, N., Ismail, A., Goor, H. van, Maier, R.V., and Catena, F.
Abstract: Item does not contain fulltext, BACKGROUND: The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants' perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness. METHODS: A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days. RESULTS: Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for sever
Published: 2022

5. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: A WSES observational study

Author: Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., Catena F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., and Catena F.
Abstract: Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8. Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
Published: 2019

6. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author: Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da Silva, A. R. A. , Augustin, G. , Bala, M. , Balogh, Z. J. , Baraket, O. , Bassetti, M. , Bellanova, G. , Beltran, M. A. , Ben-Ishay, O. , Boermeester, M. A. , Brecher, S. M. , Bueno, J. , Cainzos, M. A. , Cairns, K. , Camacho-Ortiz, A. , Ceresoli, M. , Chandy, S. J. , Cherry-Bukowiec, J. R. , Cirocchi, R. , Colak, E. , Corcione, A. , Cornely, O. A. , Cortese, F. , Cui, Y. , Curcio, D. , Damaskos, D. , Dasx, K. , Delibegovic, S. , Demetrashvili, Z. be, De Simone, B. bf, De Souza, H. P. bg, De Waele, J. bh, Dhingra, S. bi, Diaz, J. J. bj, Di Carlo, I. bk, Di Marzo, F. bl, DI TOMASO, SAVERIO, S. , Dogjani, A. , Dorj, G. , Dortet, L. , Duane, T. M. , Dupont, H. , Egiev, V. N. , Eid, H. O. , Elmangory, El-Sayed Marei, H. , Enani, M. A. , Escandón-Vargas, K. , Faro, M. P. , J.r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., Girardis, M., Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -.H., Litvin, A., Loho, T., Lowman, W., Machain, G. Mf, Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., McFarlane, M., BEZERRA DE MELO PEREIRA NUNES, CINTIA, R. , Melotti, R. , Memish, Z. , Mertz, D. , Mesina, C. , Menichetti, F. , Mishra, S. K. , Montori, G. , Moore, E. E. , Moore, F. A. , Naidoo, NAPOLITANO, NELLO, L. , Negoi, I. , Nicolau, D. P. , Nikolopoulos, I. , Nord, C. E. , Ofori-Asenso, R. , Olaoye, I. , Omari, A. H. , Ordoñez, C. A. , Ouadii, M. , Ouedraogo, A. , Pagani, L. , Paiva, J. A. , Parreira, J. G. , Pata, F. fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., ROBERTS, HENRI JOHAN EDUARD, Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., T. , Scibé, R. , Scudeller, L. , Lohse, H. S. , Sganga, G. , Shafiq, N. , Shah, J. N. , Spigaglia, P. , Suroowan, S. , Tsioutis, C. , Sifri, C. D. , Siribumrungwong, B. , Sugrue, M. , Talving, P. , Tan, B. K. , Tarasconi, A. , Tascini, C. , Tilsed, J. , Timsit, J. -.F. , Tumbarello, M. , Trung, N. T. , Ulrych, J. , Uranues, S. , Velmahos, G. , Vereczkei, A. G. , Viale, P. , Estape, J. V. , Viscoli, C. , Wagenlehner, F. , Wright, B. J. , Xiao, Y. , Yuan, K. -.C. , Zachariah, S. K. , Zahar, J. R. , Mergulhão, P. , Catena, Réanimation Médico-Chirurgicale, Groupe Hospitalier Paris Saint-Joseph, University Hospital Virgen Macarena, Internal Medicine Department, Universidad de Sevilla, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Service d'anesthésie - réanimation chirurgicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Klinik I für Innere Medizin und Zentrum für Klinische Studien (ZKS) 01KN0706, Universitätsklinikum Köln (Uniklinik Köln), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Amiens-Picardie, Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Université Catholique de Louvain = Catholic University of Louvain (UCL), Center for Disease Dynamics, Economics & Policy (CDDEP), Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Hartford Hospital, Department of Laboratory Medicine, Karolinska Institutet [Stockholm], Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Instituto Nacional de Matemática Pura e Aplicada (IMPA), Instituto Nacional de matematica pura e aplicada, 4th Department of Internal Medicine, ATTIKON University General Hospital, Department of Anesthesiology and Intensive Care, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Critical Care Department, Joan XXIII University Hospital, Departmet of Infectious, Parasitic and Immune-Mediated Disease, Istituto Superiore di Sanita [Rome], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S.Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna (UNIBO), Infectious Diseases, University of Genoa (UNIGE), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Groupe Hospitalier Paris Saint-Joseph (hpsj), Universidad de Sevilla / University of Sevilla, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Istituto Superiore di Sanità (ISS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Genova = University of Genoa (UniGe), Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Dorj, Gereltuya, Catena, Fausto, [Sartelli, Massimo] Macerata Hosp, Dept Surg, Macerata, Italy, [Scibe, Rodolfo] Macerata Hosp, Dept Surg, Macerata, Italy, [Kluger, Yoram] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ben-Ishay, Ofir] Rambam Hlth Care Campus, Dept Gen Surg, Div Surg, Haifa, Israel, [Ansaloni, Luca] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Coccolini, Federico] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Ceresoli, Marco] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Montori, Giulia] Papa Giovanni XXIII Hosp, Gen Surg Dept, Bergamo, Italy, [Carlet, Jean] World Alliance Antibiot Resistance, Paris, France, [Brink, Adrian] Milpark Hosp, Ampath Natl Lab Serv, Dept Clin Microbiol, Johannesburg, South Africa, [Brink, Adrian] Univ Cape Town, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Hardcastle, Timothy C.] Inkosi Albert Luthuli Cent Hosp, Trauma Serv, Durban, South Africa, [Hardcastle, Timothy C.] Nelson R Mandela Sch Clin Med, Dept Surg, Durban, South Africa, [Khanna, Ashish] Ctr Crit Care, Anaesthesiol Inst, Cleveland, OH USA, [Khanna, Ashish] Cleveland Clin, Dept Outcomes Res, Cleveland, OH 44106 USA, [Chicom-Mefire, Alain] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Foianini, Esteban] Univ Buea, Dept Surg & Obstet Gynaecol, Buea, Cameroon, [Rodriguez-Bano, Jesus] Hosp Univ Virgen Macarena & Virge del Rocio IbiS, Unidad Clin Interctr Enfermedades Infecciosas Mic, Seville, Spain, [Rodriguez-Bano, Jesus] Univ Seville, Dept Med, Seville, Spain, [Nathwani, Dilip] Ninewells Hosp & Med Sch, Dundee, Scotland, [Mendelson, Marc] Univ Cape Town, Groote Schuur Hosp, Dept Med, Div Infect Dis & HIV Med, Cape Town, South Africa, [Watkins, Richard R.] Cleveland Clin Akron Gen, Div Infect Dis, Akron, OH USA, [Watkins, Richard R.] Northeast Ohio Med Univ, Rootstown, OH USA, [Pulcini, Celine] Lorraine Univ, EA APEMAC 4360, Nancy, France, [Pulcini, Celine] Nancy Univ Hosp, Infect Dis Dept, Nancy, France, [Beovic, Bojana] Univ Med Ctr Ljubljana, Ljubljana, Slovenia, [Beovic, Bojana] Univ Ljubljana, Fac Med, Ljubljana, Slovenia, [May, Addison K.] Vanderbilt Univ, Med Ctr, Div Trauma & Surg Crit Care, Nashville, TN USA, [Itani, Kamal M. F.] Boston Univ, Dept Surg, VA Boston Hlth Care Syst, Boston, MA 02215 USA, [Itani, Kamal M. F.] Harvard Med Sch, Boston, MA USA, [Mazuski, John E.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA, [Fry, Donald E.] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA, [Fry, Donald E.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA, [Rasa, Kemal] Anadolu Med Ctr, Dept Surg, Kocaali, Turkey, [Montravers, Philippe] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Cite Univ, Anesthesiol & Crit Care Med, HUPNSV, Paris, France, [Eckmann, Christian] Hannover Med Sch, Acad Hosp, Dept Gen Visceral & Thorac Surg, Peine, Germany, [Abbo, Lilian M.] Univ Miami, Miller Sch Med, Jackson Hlth Syst, Div Infect Dis, Miami, FL 33136 USA, [Abbo, Lilian M.] Bayero Univ, Dept Nursing Sci, Kano, Nigeria, [Abubakar, Salisu] UAE Univ, Coll Med & Hlth Sci, Dept Surg, Al Ain, U Arab Emirates, [Abu-Zidan, Fikri M.] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Surg, Ife, Nigeria, [Al-Hasan, Majdi N.] Univ South Carolina, Sch Med, Dept Med, Div Infect Dis, Columbia, SC USA, [Althani, Asma A.] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Marei, Hany El-Sayed] Qatar Univ, Biomed Res Ctr, Doha, Qatar, [Ticas, Jorge Eduardo Alvarenga] Hosp Nacl Ros, Emergency Unit, San Salvador, El Salvador, [Ansari, Shamshul] Oita Univ, Dept Environm & Prevent Med, Fac Med, Oita, Japan, [Ansari, Shamshul] Chitwan Med Coll, Dept Microbiol, Bharatpur, Nepal, [Ansumana, Rashid] Univ Liverpool, Liverpool Sch Trop Med, Ctr Neglected Trop Dis, Bo, Sierra Leone, [Ansumana, Rashid] Njala Univ, Mercy Hosp, Res Lab, Bo, Sierra Leone, [Araujo da Silva, Andre Ricardo] Prontobaby Hosp Crianca, Infect Control Comm, Rio De Janeiro, Brazil, [Augustin, Goran] Univ Hosp Ctr, Dept Surg, Zagreb, Croatia, [Bala, Miklosh] Hadassah Hebrew Univ Med Ctr, Trauma & Acute Care Surg Unit, Jerusalem, Israel, [Balogh, Zsolt J.] John Hunter Hosp, Dept Traumatol, Newcastle, NSW, Australia, [Balogh, Zsolt J.] Univ Newcastle, Newcastle, NSW, Australia, [Baraket, Oussema] Bizerte Hosp, Dept Surg, Bizerte, Tunisia, [Bassett, Matteo] Santa Maria Misericordia Univ Hosp, Infect Dis Div, Udine, Italy, [Bellanova, Giovanni] SS Annunziata Hosp, Dept Surg, Taranto, Italy, [Beltran, Marcelo A.] Hosp San Juan Dios, Dept Gen Surg, La Serena, Chile, [Biffl, Walter L.] Queens Med Ctr, Acute Care Surg, Honolulu, HI USA, [Boermeester, Marja A.] Acad Med Ctr, Dept Surg, Amsterdam, Netherlands, [Brecher, Stephen M.] Boston Univ, Sch Med, VA Boston HealthCare Syst, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Brecher, Stephen M.] Boston Univ, Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA, [Bueno, Juan] Fdn Ctr Invest Bioprospecc & Biotecnol Biodivers, Barranquilla, Colombia, [Cainzos, Miguel A.] Hosp Clin Univ, Dept Surg, Santiago De Compostela, Spain, [Cairns, Kelly] Alfred Hlth, Pharm Dept, Melbourne, Vic, Australia, [Camacho-Ortiz, Adrian] Hosp Univ Dr Jose Eleuterio Gonzalez, Hosp Epidemiol & Infect Dis, Monterrey, Mexico, [Chandy, Sujith J.] Christian Med Coll & Hosp, Dept Pharmacol & Clin Pharmacol, Vellore, Tamil Nadu, India, [Cherry-Bukowiec, Jill R.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA, [Cirocchi, Roberto] Univ Perugia, Dept Gen & Oncol Surg, Terni, Italy, [Colak, Elif] Hlth Sci Univ, Samsun Training & Res Hosp, Dept Gen Surg, Samsun, Turkey, [Corcione, Antonio] AORN Colli Vincenzo Monaldi Hosp, Anesthesia & Intens Care Unit, Naples, Italy, [Cornely, Oliver A.] Univ Cologne, German Ctr Infect Res DZIF, Dept Internal Med 1, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany, [Cortese, Francesco] San Filippo Neris Hosp, Emergency Surg Unit, Rome, Italy, [Cui, Yunfeng] Tianjin Med Univ, Tianjin Nankai Hosp, Dept Surg, Nankai Clin Sch Med, Tianjin, Peoples R China, [Curcio, Daniel] Buenos Aires Univ, Infectol Inst SRL, Buenos Aires, DF, Argentina, [Damaskos, Dimitris] Royal Infirm Edinburgh NHS Trust, Dept Surg, Edinburgh, Midlothian, Scotland, [Das, Koray] Ankara Numune Training & Res Hosp, Dept Surg, Adana, Turkey, [Delibegovic, Samir] Univ Clin Ctr Tuzla, Dept Surg, Tuzla, Bosnia & Herceg, [Deme-Trashvili, Zaza] Kipshidze Cent Univ Hosp, Dept Gen Surg, Tbilisi, Georgia, [De Simone, Belinda] Cannes Hosp, Dept Digest Surg, Cannes, France, [de Souza, Hamilton Petry] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Sch Med, Dept Surg, Porto Alegre, RS, Brazil, [De Waele, Jan] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium, [Dhingra, Sameer] Univ West Indies, Eric Williams Med Sci Complex, Sch Pharm, Fac Med Sci, Uriah Butler Highway, Champ Fleurs, Trinidad Tobago, [Diaz, Jose J.] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Div Acute Care Surg, Program Trauma, Baltimore, MD 21201 USA, [Di Carlo, Isidoro] Univ Catania, Cannizzaro Hosp, Dept Surg Sci, Catania, Italy, [Di Marzo, Francesco] Versilia Hosp, Gen Surg, Usl Nordovest, Tuscany, Italy, [Di Saverio, Salomone] Maggiore Hosp, Dept Surg, Bologna, Italy, [Dogjani, Agron] Univ Hosp Trauma, Dept Surg, Tirana, Albania, [Dorj, Gereltuya] Mongolian Natl Univ Med Sci, Sch Pharm, Ulaanbaatar, Mongolia, [Dortet, Laurent] Paris Sud Univ, Bicetre Hosp, Dept Microbiol, La Kremlin Bicetre, France, [Duane, Therese M.] John Peter Smith Hlth Network, Dept Surg, Ft Worth, TX USA, [Dupont, Herve] Univ Picardie Jules Verne, CHU Amiens Picardie, Dept Anesthesie Reanimat, Amiens, France, [Dupont, Herve] Univ Picardie Jules Verne, INSERM, U1088, Amiens, France, [Egiev, Valery N.] Pirogov Russian Natl Res Med Univ, Dept Surg, Moscow, Russia, [Eid, Hani O.] Al Ain Hosp, Mediclin Middle East, Dept Emergency Med, Al Ain, U Arab Emirates, [Elmangory, Mutasim] Fed Minist Hlth, Sudan Natl Publ Hlth Lab, Khartoum, Sudan, [Enani, Mushira Abdulaziz] King Fahad Med City, Div Infect Dis, Dept Med, Riyadh, Saudi Arabia, [Escandon-Vargas, Kevin] Univ Valle, Escuela Med, Fac Salud, Cali, Colombia, [Faro Junior, Mario P.] ABC Med Sch, Dept Gen Surg Trauma, Santo Andre, SP, Brazil, [Faro Junior, Mario P.] ABC Med Sch, Emergency Surg Div, Santo Andre, SP, Brazil, [Ferrada, Paula] Virginia Commonwealth Univ, Dept Surg, Richmond, VA USA, [Foghetti, Domitilla] Pesaro Hosp, Dept Surg, Pesaro, Italy, Clin Foianini, Dept Surg, Santa Cruz, Bolivia, [Fraga, Gustavo P.] Univ Campinas Unicamp, Sch Med Sci, Dept Surg, Div Trauma Surg, Campinas, SP, Brazil, [Frattima, Sabrina] Ist Clin San Rocco Franciacorta, Brescia, Italy, [Gandhi, Chinmay] Bharati Vidyapeeth Deemed Univ Med Coll & Hosp, Dept Surg, Sangli, Maharashtra, India, [Gattuso, Gianni] C Poma Hosp, Infect Dis Dept, Mantua, Italy, [Giamarellou, Eleni] Hygeia Gen Hosp, Dept Internal Med 6, Athens, Greece, [Ghnnam, Wagih] Mansoura Univ, Mansoura Fac Med, Dept Gen Surg, Mansoura, Egypt, [Gkiokas, George] Natl & Kapodistrian Univ Athens, Aretaieion Univ Hosp, Dept Surg 2, Athens, Greece, [Girardis, Massimo] Modena Univ Hosp, Intens Care Unit, Modena, Italy, [Goff, Debbie A.] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA, [Gomes, Carlos Augusto] Hosp Univ Terezinha Jesus, Dept Surg, Fac Ciencias Med & Saude Juiz de Fora, Juiz De Fora, Brazil, [Gomi, Harumi] Univ Tsukuba, Mito Kyodo Gen Hosp, Ctr Global Hlth, Mito, Ibaraki, Japan, [Guerra Gronerth, Rosio Isabel] Peruvian Navy Med Ctr, Lima, Peru, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Endocrine Head & Neck Surg, Sabadell, Spain, [Guirao, Xavier] Parc Tauli Univ Hosp, Dept Gen Surg, Unit Surg Infect Support, Sabadell, Spain, [Guzman-Blanco, Manuel] Hosp Privado Ctr Med Caracas, Caracas, Venezuela, [Guzman-Blanco, Manuel] Hosp Vargas Caracas, Caracas, Venezuela, [Haque, Mainul] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Reichert, Martin] Univ Pertahanan Nasional Malaysia, Natl Def Univ Malaysia, Unit Pharmacol, Fac Med & Def Hlth, Kuala Lumpur, Malaysia, [Hecker, Andreas] Univ Hosp Giessen, Dept Gen & Thorac Surg, Giessen, Germany, [Hell, Markus] Paracelsus Med Univ, Acad Teaching Lab, Clin Microbiol & Infect Control, MEDILAB Dr Mustafa Dr Richter OG, Salzburg, Austria, [Herzog, Torsten] Ruhr Univ Bochum, St Josef Hosp, Dept Surg, Bochum, Germany, [Hicks, Lauri] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA, [Kafka-Ritsch, Reinhold] Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria, [Kao, Lillian S.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX 77030 USA, [Kanj, Souha S.] Amer Univ Beirut, Dept Internal Med, Div Infect Dis, Beirut, Lebanon, [Kaplan, Lewis J.] Univ Penn, Perelman Sch Med, Philadelphia VA Med Ctr, Dept Surg, Philadelphia, PA 19104 USA, [Kapoor, Garima] Gandhi Med Coll, Dept Microbiol, Bhopal, India, [Karamarkovic, Aleksandar] Univ Belgrade, Clin Emergency Surg, Med Fac, Belgrade, Serbia, [Kashuk, Jeffry] Tel Aviv Univ, Dept Surg, Assia Med Grp, Sackler Sch Med, Tel Aviv, Israel, [Kenig, Jakub] Jagiellonian Univ, Med Coll, Dept Gen Surg 3, Krakow, Poland, [Khamis, Faryal] Royal Hosp, Dept Internal Med, Muscat, Oman, [Khokha, Vladimir] City Hosp, Dept Emergency Surg, Mozyr, BELARUS, [Kiguba, Ronald] Makerere Univ, Dept Pharmacol & Therapeut, Coll Hlth Sci, Kampala, Uganda, [Kirkpatrick, Andrew W.] Foothills Med Ctr, Gen Acute Care Abdominal Wall Reconstruct & Traum, Calgary, AB, Canada, [Korner, Hartwig] Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway, [Koike, Kaoru] Kyoto Univ, Grad Sch Med, Dept Primary Care & Emergency Med, Kyoto, Japan, [Kok, Kenneth Y. Y.] Brunei Canc Ctr, Dept Surg, Jerudong Pk, Jerudong, Brunei, [Kon, Kateryna] Kharkiv Natl Med Univ, Dept Microbiol Virol & Immunol, Kharkov, Ukraine, [Kong, Victor] Edendale Hosp, Dept Surg, Pietermaritzburg, South Africa, [Inaba, Kenji] Univ Southern Calif, Los Angeles Cty & Univ So Cali fornia Med Ctr, Div Acute Care Surg & Surg Crit Care, Dept Surg, Los Angeles, CA USA, [Ioannidis, Orestis] Aristotle Univ Thessaloniki, Gen Hosp G Papanikolaou, Surg Dept 4, Med Sch, Thessaloniki, Greece, [Isik, Arda] Erzincan Univ, Dept Gen Surg, Fac Med, Erzincan, Turkey, [Iskandar, Katia] Lebanese Int Univ, Dept Pharm, Beirut, Lebanon, [Labbate, Maurizio] Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia, [Labbate, Maurizio] Univ Technol Sydney, Inst I3, Sydney, NSW, Australia, [Labricciosa, Francesco M.] UNIVPM, Dept Biomed Sci & Publ Hlth, Unit Hyg Prevent Med & Publ Hlth, Ancona, Italy, [Lagrou, Katrien] Univ Hosp Leuven, Clin Dept Lab Med, Leuven, Belgium, [Lagrou, Katrien] Katholieke Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium, [Lagunes, Leonel] Hosp Cent Dr Ignacio Morones Prieto, San Luis Potosi, Mexico, [Latifi, Rifat] Univ Arizona, Dept Surg, Div Trauma, Tucson, AZ USA, [Lasithiotakis, Kostas] York Teaching Hosp NHS Fdn Trust, Dept Surg, York, N Yorkshire, England, [Laxminarayan, Ramanan] Ctr Dis Dynam Econ & Policy, Washington, DC USA, [Lee, Jae Gil] Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea, [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Dept Anaesthesiol & Crit Care, Marseille, France, [Leppaniemi, Ari] Univ Hosp Meilahti, Abdominal Ctr, Helsinki, Finland, [Li, Yousheng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Surg, Shanghai, Peoples R China, [Liang, Stephen Y.] Washington Univ, Sch Med, Div Infect Dis, Div Emergency Med, St Louis, MO USA, [Liau, Kui-Hin] Natl Univ Singapore, Mt Elizabeth Novena Hosp, Singapore & Yong Loo Lin Sch Med, Dept Surg,Liau KH Consulting, Singapore, Singapore, [Litvin, Andrey] Immanuel Kant Balt Fed Univ, Surg Disciplines, Reg Clin Hosp, Kaliningrad, Russia, [Loho, Tonny] Univ Indonesia, Cipto Mangunkusumo Gen Hosp, Dept Clin Pathol, Div Infect Dis,Fac Med, Jakarta, Indonesia, [Lowman, Warren] Univ Witwatersrand, Sch Pathol, Vermaak Partners Pathcare Pathologists, Clin Microbiol & Infect Dis,Fac Hlth Sci, Johannesburg, South Africa, [Lowman, Warren] Wits Donald Gordon Med Ctr, Johannesburg, South Africa, [Machain, Gustavo M.] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Segovia Lohse, Helmut] Univ Nacl Asuncion, Dept Surg, Asuncion, Paraguay, [Maier, Ronald V.] Univ Washington, Dept Surg, Seattle, WA 98195 USA, [Manzano-Nunez, Ramiro] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia, [Marinis, Athanasios] Tzane Gen Hosp, Dept Surg 1, Piraeus, Greece, [Marmorale, Cristina] Univ Politecn Marche, Dept Surg, Ancona, Italy, [Martin-Loeches, Ignacio] St James Univ Hosp, Trin Ctr Hlth Sci, Dept Clin Med, Wellcome Trust HRB Clin Res,MICRO, Dublin, Ireland, [Marwah, Sanjay] Postgrad Inst Med Sci, Dept Surg, Rohtak, Haryana, India, [Maseda, Emilio] Hosp Univ La Paz Madrid, Serv Anestesia & Reanimac, Madrid, Spain, [McFarlane, Michael] Univ Hosp West Indies, Dept Surg Radiol, Kingston, Jamaica, [de Melo, Renato Bessa] Ctr Hosp Sao Joao, Gen Surg Dept, Porto, Portugal, [Melotti, Maria Rita] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Anesthesiol & Intens Care, Bologna, Italy, [Memish, Ziad] Minist Hlth, Prince Mohamed Bin Abdulaziz Hosp, Dept Med, Infect Dis Div, Riyadh, Saudi Arabia, [Mertz, Dominik] McMaster Univ, Dept Med, Hamilton, ON, Canada, [Mertz, Dominik] McMaster Univ, Dept Clin Epidemiol & Biostat, Dept Pathol & Mol Med, Hamilton, ON, Canada, [Mesina, Cristian] Emergency Hosp Craiova, Surg Clin 2, Craiova, Romania, [Menichetti, Francesco] Univ Hosp Pisa, Infect Dis Unit, Pisa, Italy, [Mishra, Shyam Kumar] Tribhuvan Univ, Teaching Hosp, Inst Med, Dept Microbiol, Kathmandu, Nepal, [Moore, Ernest E.] Univ Colorado, Denver Hlth Med Ctr, Dept Surg, Denver, CO 80202 USA, [Moore, Frederick A.] Univ Florida, Coll Med, Dept Surg, Div Acute Care Surg, Gainesville, FL USA, [Moore, Frederick A.] Univ Florida, Coll Med, Ctr Sepsis & Crit Illness Res, Gainesville, FL USA, [Naidoo, Noel] Univ KwaZulu Natal, Dept Surg, Durban, South Africa, [Napolitano, Lena] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA, [Negoi, Ionut] Emergency Hosp Bucharest, Dept Surg, Bucharest, Romania, [Nicolau, David P.] Ctr Anti Infect Res & Dev, Hartford, CT USA, [Nikolopoulos, Ioannis] Lewisham & Greenwich NHS Trust, Dept Gen Surg, London, England, [Nord, Carl Erik] Karolinska Univ, Huddinge Hosp, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden, [Ofori-Asenso, Richard] Hlth Policy Consult, Res Unit, Weija, Accra, Ghana, [Olaoye, Iyiade] Univ Ilorin, Teaching Hosp, Dept Surg, Ilorin, Nigeria, [Omari, Abdelkarim H.] King Abdullah Univ Hosp, Dept Surg, Irbid, Jordan, [Ordonez, Carlos A.] Univ Valle, Fdn Valle Lili, Dept Surg & Crit Care, Cali, Colombia, [Ouadii, Mouaqit] Sidi Mohamed Benabdellah Univ, Hassan Univ Hosp 2, Dept Surg, Med Sch Fez, Fes, Morocco, [Ouedraogo, Abdoul-Salam] CHU Souro Sanou, Bacteriol & Virol Dept, Bobo Dioulasso, Burkina Faso, [Pagani, Leonardo] Bolzano Cent Hosp, Infect Dis Unit, Bolzano, Italy, [Paiva, Jose Artur] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Mergulhao, Paulo] Univ Porto, Ctr Hosp Sao Joao, Intens Care Med Dept, Porto, Portugal, [Parreira, Jose Gustavo] Santa Casa Sao Paulo Sch Med Sci, Dept Surg, Sao Paulo, Brazil, [Pata, Francesco] St Antonio Abate Hosp, Dept Surg, Gallarate, Italy, [Pereira, Jorge] Ctr Hosp Tondela Viseu, Surg Unit 1, Viseu, Portugal, [Pereira, Nuno R.] Sao Joao Hosp Ctr, Ctr Hosp Epidemiol, Unit Prevent & Infect Control, Porto, Portugal, [Petrosillo, Nicola] INMI Lazzaro Spallanzani IRCCS, Natl Inst Infect Dis, Rome, Italy, [Picetti, Edoardo] Univ Parma, Azienda Osped, Dept Anesthesia & Intens Care, Parma, Italy, [Pintar, Tadeja] UMC Ljubljana, Dept Surg, Ljubljana, Slovenia, [Ponce-de-Leon, Alfredo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Infect Dis, Lab Clin Microbiol, Mexico City, DF, Mexico, [Popovski, Zagorka] Hamilton Hlth Sci, Hamilton, ON, Canada, [Popovski, Zagorka] London Hlth Sci, London, ON, Canada, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Dept Internal Med 4, Athens, Greece, [Poulakou, Garyphallia] Attikon Univ Gen Hosp, Med Sch, Natl & Kapodistrian Univ Athens, Infect Dis Unit, Athens, Greece, [Preller, Jacobus] Univ Hosp NHS Fdn Trust, John Farman Intens Care Unit, Cambridge, England, [Guerrero, Adrian Puello] Univ Autonoma Santo Domingo, Inst Nacl Canc Rosa Tavares INCART, Santo Domingo, Dominican Rep, [Pupelis, Guntars] Riga East Univ Hosp Gailezers, Dept Gen & Emergency Surg, Riga, Latvia, [Quiodettis, Martha] Hosp Santo Tomas, Dept Trauma, Panama City, Panama, [Rawson, Timothy M.] Natl Inst Hlth Res, Imperial Coll London, Hlth Protect Res Unit Healthcare Associated Infec, Hammersmith Campus, London, England, [Reinhart, Konrad] Jena Univ Hosp, Dept Anesthesiol & Intens Care Med, Jena, Thuringen, Germany, [Rems, Miran] Jesenice Gen Hosp, Dept Gen Surg, Jesenice, Slovenia, [Rello, Jordi] VHIR, Dept Clin Res & Innovat Pneumonia & Sepsis, Barcelona, Spain, [Rizoli, Sandro] Univ Toronto, St Michaels Hosp, Trauma & Acute Care Serv, Toronto, ON, Canada, [Roberts, Jason] Univ Queensland, Fac Med, Brisbane, Qld, Australia, [Rubio-Perez, Ines] La Paz Univ Hosp, Gen Surg Dept, Colorectal Surg Unit, Madrid, Spain, [Ruppc, Etienne] Bichat Claude Bernard Univ Hosp, Paris Diderot Sorbonne Univ, Serv Bacteriol, HUPNSV, Paris, France, [Sakakushev, Boris] Univ Hosp St George, Med Univ, Gen Surg Dept, Plovdiv, Bulgaria, [Sall, Ibrahima] Mil Teaching Hosp, Gen Surg Dept, Dakar, Senegal, [Kafil, Hossein Samadi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran, [Sanders, James] JPS Hlth Network, Ft Worth, TX USA, [Sato, Norio] Ehime Univ, Grad Sch Med, Dept Aeromed Serv Emergency & Trauma Care, Matsuyama, Ehime, Japan, [Sawyer, Robert G.] Western Michigan Univ, Sch Med, Dept Surg, Kalamazoo, MI 49008 USA, [Scalea, Thomas] Univ Maryland, Sch Med, Dept Trauma Surg, Baltimore, MD 21201 USA, [Scudeller, Luigia] IRCCS Policlin San Matteo Fdn, Clin Epidemiol Unit, Pavia, Italy, [Sganga, Gabriele] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Dept Surg, Rome, Italy, [Shafiq, Nusrat] Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh, India, [Shah, Jay N.] Patan Acad Hlth Sci, Dept Surg Patan Hosp, Kathmandu, Nepal, [Spigaglia, Patrizia] Ist Super Sanita, Dept Infect Dis, Rome, Italy, [Suroowan, Shanoo] Univ Mauritius, Dept Hlth Sci, Fac Sci, Reduit, Mauritius, [Tsioutis, Constantinos] European Univ Cyprus, Sch Med, Nicosia, Cyprus, [Sifri, Costi D.] Univ Virginia Hlth Syst, Off Hosp Epidemiol Infect Prevent & Control, Charlottesville, VA USA, [Siribumrungwong, Boonying] Thammasat Univ Hosp, Thammasat Univ, Dept Surg, Fac Med, Pathum Thani, Thailand, [Sugrue, Michael] Letterkenny Hosp, Gen Surg Dept, Letterkenny, Ireland, [Talving, Peep] North Estonia Med Ctr, Dept Surg, Tallinn, Estonia, [Tan, Boun Kim] Ctr Hosp St Joseph St Luc, Intens Care Unit, Lyon, France, [Tarasconi, Antonio] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Catena, Fausto] Parma Maggiore Hosp, Dept Emergency Surg, Parma, Italy, [Tascini, Carlo] Cotugno Hosp, Azienda Osped Colli, Div Infect Dis 1, Naples, Italy, [Tilsed, Jonathan] Hull & East Yorkshire Hosp NHS Trust, Surg Hlth Care Grp, Kingston Upon Hull, N Humberside, England, [Timsit, Jean-Francois] Hop Xavier Bichat, PHP Med & Infect Dis ICU, Paris, France, [Tumbarello, Mario] Catholic Univ, Inst Infect Dis, Rome, Italy, [Ngo Tat Trung] Tran Hung Dao Hosp, Dept Mol Biol, Hanoi, Vietnam, [Ulrych, Jan] Charles Univ Prague, Fac Med 1, Dept Surg 1, Prague, Czech Republic, [Ulrych, Jan] Gen Univ Hosp Prague, Prague, Czech Republic, [Uranues, Selman] Med Univ Graz, Dept Surg, Graz, Austria, [Velmahos, George] Massachusetts Gen Hosp, Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA, [Vereczkei, Andras G.] Med Sch Univ Pecs, Dept Surg, Pecs, Hungary, [Viale, Pierluigi] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, Bologna, Italy, [Vila Estape, Jordi] Univ Barcelona, ISGlobal Hosp Clin, Inst Salud Global, Barcelona, Spain, [Viscoli, Claudio] Univ Genoa DISSAL, Osped Policlin San Martino IRCCS Oncol, Infect Dis Unit, Genoa, Italy, [Wagenlehner, Florian] Univ Giessen, Dept Urol Pediat Urol & Androl, Med Fac Justus Liebig, Giessen, Germany, [Wright, Brian J.] SUNY Stony Brook, Sch Med, Dept Emergency Med & Neurosurg, Stony Brook, NY 11794 USA, [Xiao, Yonghong] Zhejiang Univ, Affilliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China, [Yuan, Kuo-Ching] Chang Gung Mem Hosp, Trauma & Emergency Surg Dept, Taoyuan, Taiwan, [Zachariah, Sanoop K.] MOSC Med Coll Kolenchery, Dept Surg, Cochin, Kerala, India, [Zahar, Jean Ralph] Angers Univ, CHU Angers, Infect Control Unit, Angers, France, COMBE, Isabelle, Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli, M., Kluger, Y., Ansaloni, L., Carlet, J., Brink, A., Hardcastle, T. C., Khanna, A., Chicom-Mefire, A., Rodríguez-Baño, J., Nathwani, D., Mendelson, M., Watkins, R. R., Pulcini, C., Beović, B., May, A. K., Itani, K. M. F., Mazuski, J. E., Fry, D. E., Coccolini, F., Rasxa, K., Montravers, P., Eckmann, C., Abbo, L. M., Abubakar, S., Abu-Zidan, F. M., Adesunkanmi, A. K., Al-Hasan, M. N., Althani, A. A., Ticas, J. E. A., Ansari, S., Ansumana, R., Da, Silva, Augustin, A. R. A., Bala, G., Balogh, M., Baraket, Z. J., Bassetti, O., Bellanova, M., Beltran, G., Ben-Ishay, M. A., Boermeester, O., Brecher, M. A., Bueno, S. M., Cainzos, J., Cairns, M. A., Camacho-Ortiz, K., Ceresoli, A., Chandy, M., Cherry-Bukowiec, S. J., Cirocchi, J. R., Colak, R., Corcione, E., Cornely, A., Cortese, O. A., Cui, F., Curcio, Y., Damaskos, D., Dasx, D., Delibegovic, K., Demetrashvili, S., Be, Z., Simone, De, Bf, B., De, Souza, Bg, H. P., De, Waele, Bh, J., Dhingra, Bi, S., Diaz, Bj, J. J., Carlo, Di, Bk, I., Di, Marzo, Bl, F., Saverio, Di, Dogjani, S., Dorj, A., Dortet, G., Duane, L., Dupont, T. M., Egiev, H., Eid, V. N., Elmangory, H. O., El-Sayed, Marei, Enani, H., Escandón-Vargas, M. A., Faro, K., M. P., J. r., Ferrada, P., Foghetti, D., Foianini, E., Fraga, G. P., Frattima, S., Gandhi, C., Gattuso, G., Giamarellou, E., Ghnnam, W., Gkiokas, G., M., Girardi, Goff, D. A., Gomes, C. A., Gomi, H., Gronerth, R. I. G., Guirao, X., Guzman-Blanco, M., Haque, M., Hecker, A., Hell, M., Herzog, T., Hicks, L., Kafka-Ritsch, R., Kao, L. S., Kanj, S. S., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kashuk, J., Kenig, J., Khamis, F., Khokha, V., Kiguba, R., Kirkpatrick, A. W., Kørner, H., Koike, K., Kok, K. Y. Y., Kon, K., Kong, V., Inaba, K., Ioannidis, O., Isik, A., Iskandar, K., Labbate, M., Labricciosa, F. M., Lagrou, K., Lagunes, L., Latifi, R., Lasithiotakis, K., Laxminarayan, R., Lee, J. G., Leone, M., Leppäniemi, A., Li, Y., Liang, S. Y., Liau, K. -. H., Litvin, A., Loho, T., Lowman, W., Machain, Mf, G., Maier, R. V., Manzano-Nunez, R., Marinis, A., Marmorale, C., Martin-Loeches, I., Marwah, S., Maseda, E., Mcfarlane, M., De, Melo, Melotti, R., Memish, R., Mertz, Z., Mesina, D., Menichetti, C., Mishra, F., Montori, S. K., Moore, G., Moore, E. E., Naidoo, F. A., Napolitano, N., Negoi, L., Nicolau, I., Nikolopoulos, D. P., Nord, I., Ofori-Asenso, C. E., Olaoye, R., Omari, I., Ordoñez, A. H., Ouadii, C. A., Ouedraogo, M., Pagani, A., Paiva, L., Parreira, J. A., Pata, J. G., F., Fm, Pereira, J., Pereira, N. R., Petrosillo, N., Picetti, E., Pintar, T., Ponce-De-Leon, A., Popovski, Z., Poulakou, G., Preller, J., Guerrero, A. P., Pupelis, G., Quiodettis, M., Rawson, T. M., Reichert, M., Reinhart, K., Rems, M., Rello, J., Rizoli, S., Roberts, J., Rubio-Perez, I., Ruppé, E., Sakakushev, B., Sall, I., Kafil, H. S. j, Sanders, J., Sato, N., Sawyer, R. G., Scibé, T., Scudeller, R., Lohse, L., Sganga, H. S., Shafiq, G., Shah, N., Spigaglia, J. N., Suroowan, P., Tsioutis, S., Sifri, C., Siribumrungwong, C. D., Sugrue, B., Talving, M., Tan, P., Tarasconi, B. K., Tascini, A., Tilsed, C., Timsit, J., Tumbarello, J. -. F., Trung, M., Ulrych, N. T., Uranues, J., Velmahos, S., Vereczkei, G., Viale, A. G., Estape, P., Viscoli, J. V., Wagenlehner, C., Wright, F., Xiao, B. J., Yuan, Y., Zachariah, K. -. C., Zahar, S. K., Mergulhão, J. R., and Catena, P.
Subjects: 0301 basic medicine, antibiotic agent, antifungal agent antiinfective agent, Antifungal Agents, Drug Resistance, Declaration, Inappropriate Prescribing, 030230 surgery, Global Health, Antimicrobial Stewardship, Microbial, 0302 clinical medicine, Anti-Infective Agents, Health care, Global health, Antimicrobial stewardship, Antibiotic prophylaxis, Antibiotic stewardship, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Drug Resistance, Microbial, Public relations, Antimicrobial, Operative, Anti-Bacterial Agents, Antibiotic Prophylaxis, Humans, Surgical Procedures, Operative, Surgical Wound Infection, Surgery, Microbiology (medical), Infectious Diseases, 3. Good health, surgical infections, medicine.medical_specialty, 030106 microbiology, Guidelines, 03 medical and health sciences, Antibiotic resistance, medicine, Ventilator-associated pneumonia, Adults, Surgical Procedures, business.industry, Carbapenems, Therapy, business, hospitals, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.
Published: 2017
Full Text: View/download PDF

7. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author: Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli M., Kluger Y., Ansaloni L., Carlet J., Brink A., Hardcastle T. C., Khanna A., Chicom-Mefire A., Rodriguez-Bano J., Nathwani D., Mendelson M., Watkins R. R., Pulcini C., Beovic B., May A. K., Itani K. M. F., Mazuski J. E., Fry D. E., Coccolini F., Rasxa K., Montravers P., Eckmann C., Abbo L. M., Abubakar S., Abu-Zidan F. M., Adesunkanmi A. K., Al-Hasan M. N., Althani A. A., Ticas J. E. A., Ansari S., Ansumana R., Da Silva A. R. A., Augustin G., Bala M., Balogh Z. J., Baraket O., Bassetti M., Bellanova G., Beltran M. A., Ben-Ishay O., Biffl W. L., Boermeester M. A., Brecher S. M., Bueno J., Cainzos M. A., Cairns K., Camacho-Ortiz A., Ceresoli M., Chandy S. J., Cherry-Bukowiec J. R., Cirocchi R., Colak E., Corcione A., Cornely O. A., Cortese F., Cui Y., Curcio D., Damaskos D., Dasx K., Delibegovic S., Demetrashvili Z., De Simone B., De Souza H. P., De Waele J., Dhingra S., Diaz J. J., Di Carlo I., Di Marzo F., Di Saverio S., Dogjani A., Dorj G., Dortet L., Duane T. M., Dupont H., Egiev V. N., Eid H. O., Elmangory M., El-Sayed Marei H., Enani M. A., Escandon-Vargas K., Faro M. P., Ferrada P., Foghetti D., Foianini E., Fraga G. P., Frattima S., Gandhi C., Gattuso G., Giamarellou E., Ghnnam W., Gkiokas G., Girardis M., Goff D. A., Gomes C. A., Gomi H., Gronerth R. I. G., Guirao X., Guzman-Blanco M., Haque M., Hecker A., Hell M., Herzog T., Hicks L., Kafka-Ritsch R., Kao L. S., Kanj S. S., Kaplan L. J., Kapoor G., Karamarkovic A., Kashuk J., Kenig J., Khamis F., Khokha V., Kiguba R., Kirkpatrick A. W., Korner H., Koike K., Kok K. Y. Y., Kon K., Kong V., Inaba K., Ioannidis O., Isik A., Iskandar K., Labbate M., Labricciosa F. M., Lagrou K., Lagunes L., Latifi R., Lasithiotakis K., Laxminarayan R., Lee J. G., Leone M., Leppaniemi A., Li Y., Liang S. Y., Liau K. -H., Litvin A., Loho T., Lowman W., Machain G. M., Maier R. V., Manzano-Nunez R., Marinis A., Marmorale C., Martin-Loeches I., Marwah S., Maseda E., McFarlane M., De Melo R. B., Melotti M. R., Memish Z., Mertz D., Mesina C., Menichetti F., Mishra S. K., Montori G., Moore E. E., Moore F. A., Naidoo N., Napolitano L., Negoi I., Nicolau D. P., Nikolopoulos I., Nord C. E., Ofori-Asenso R., Olaoye I., Omari A. H., Ordonez C. A., Ouadii M., Ouedraogo A. -S., Pagani L., Paiva J. A., Parreira J. G., Pata F., Pereira J., Pereira N. R., Petrosillo N., Picetti E., Pintar T., Ponce-De-Leon A., Popovski Z., Poulakou G., Preller J., Guerrero A. P., Pupelis G., Quiodettis M., Rawson T. M., Reichert M., Reinhart K., Rems M., Rello J., Rizoli S., Roberts J., Rubio-Perez I., Ruppe E., Sakakushev B., Sall I., Kafil H. S., Sanders J., Sato N., Sawyer R. G., Scalea T., Scibe R., Scudeller L., Lohse H. S., Sganga G., Shafiq N., Shah J. N., Spigaglia P., Suroowan S., Tsioutis C., Sifri C. D., Siribumrungwong B., Sugrue M., Talving P., Tan B. K., Tarasconi A., Tascini C., Tilsed J., Timsit J. -F., Tumbarello M., Trung N. T., Ulrych J., Uranues S., Velmahos G., Vereczkei A. G., Viale P., Estape J. V., Viscoli C., Wagenlehner F., Wright B. J., Xiao Y., Yuan K. -C., Zachariah S. K., Zahar J. R., Mergulhao P., Catena F., Sartelli, M, Kluger, Y, Ansaloni, L, Carlet, J, Brink, A, Hardcastle, T, Khanna, A, Chicom-Mefire, A, Rodriguez-Bano, J, Nathwani, D, Mendelson, M, Watkins, R, Pulcini, C, Beovic, B, May, A, Itani, K, Mazuski, J, Fry, D, Coccolini, F, Rasxa, K, Montravers, P, Eckmann, C, Abbo, L, Abubakar, S, Abu-Zidan, F, Adesunkanmi, A, Al-Hasan, M, Althani, A, Ticas, J, Ansari, S, Ansumana, R, Da Silva, A, Augustin, G, Bala, M, Balogh, Z, Baraket, O, Bassetti, M, Bellanova, G, Beltran, M, Ben-Ishay, O, Biffl, W, Boermeester, M, Brecher, S, Bueno, J, Cainzos, M, Cairns, K, Camacho-Ortiz, A, Ceresoli, M, Chandy, S, Cherry-Bukowiec, J, Cirocchi, R, Colak, E, Corcione, A, Cornely, O, Cortese, F, Cui, Y, Curcio, D, Damaskos, D, Dasx, K, Delibegovic, S, Demetrashvili, Z, De Simone, B, De Souza, H, De Waele, J, Dhingra, S, Diaz, J, Di Carlo, I, Di Marzo, F, Di Saverio, S, Dogjani, A, Dorj, G, Dortet, L, Duane, T, Dupont, H, Egiev, V, Eid, H, Elmangory, M, El-Sayed Marei, H, Enani, M, Escandon-Vargas, K, Faro, M, Ferrada, P, Foghetti, D, Foianini, E, Fraga, G, Frattima, S, Gandhi, C, Gattuso, G, Giamarellou, E, Ghnnam, W, Gkiokas, G, Girardis, M, Goff, D, Gomes, C, Gomi, H, Gronerth, R, Guirao, X, Guzman-Blanco, M, Haque, M, Hecker, A, Hell, M, Herzog, T, Hicks, L, Kafka-Ritsch, R, Kao, L, Kanj, S, Kaplan, L, Kapoor, G, Karamarkovic, A, Kashuk, J, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kirkpatrick, A, Korner, H, Koike, K, Kok, K, Kon, K, Kong, V, Inaba, K, Ioannidis, O, Isik, A, Iskandar, K, Labbate, M, Labricciosa, F, Lagrou, K, Lagunes, L, Latifi, R, Lasithiotakis, K, Laxminarayan, R, Lee, J, Leone, M, Leppaniemi, A, Li, Y, Liang, S, Liau, K, Litvin, A, Loho, T, Lowman, W, Machain, G, Maier, R, Manzano-Nunez, R, Marinis, A, Marmorale, C, Martin-Loeches, I, Marwah, S, Maseda, E, Mcfarlane, M, De Melo, R, Melotti, M, Memish, Z, Mertz, D, Mesina, C, Menichetti, F, Mishra, S, Montori, G, Moore, E, Moore, F, Naidoo, N, Napolitano, L, Negoi, I, Nicolau, D, Nikolopoulos, I, Nord, C, Ofori-Asenso, R, Olaoye, I, Omari, A, Ordonez, C, Ouadii, M, Ouedraogo, A, Pagani, L, Paiva, J, Parreira, J, Pata, F, Pereira, J, Pereira, N, Petrosillo, N, Picetti, E, Pintar, T, Ponce-De-Leon, A, Popovski, Z, Poulakou, G, Preller, J, Guerrero, A, Pupelis, G, Quiodettis, M, Rawson, T, Reichert, M, Reinhart, K, Rems, M, Rello, J, Rizoli, S, Roberts, J, Rubio-Perez, I, Ruppe, E, Sakakushev, B, Sall, I, Kafil, H, Sanders, J, Sato, N, Sawyer, R, Scalea, T, Scibe, R, Scudeller, L, Lohse, H, Sganga, G, Shafiq, N, Shah, J, Spigaglia, P, Suroowan, S, Tsioutis, C, Sifri, C, Siribumrungwong, B, Sugrue, M, Talving, P, Tan, B, Tarasconi, A, Tascini, C, Tilsed, J, Timsit, J, Tumbarello, M, Trung, N, Ulrych, J, Uranues, S, Velmahos, G, Vereczkei, A, Viale, P, Estape, J, Viscoli, C, Wagenlehner, F, Wright, B, Xiao, Y, Yuan, K, Zachariah, S, Zahar, J, Mergulhao, P, Catena, F, Sartelli M., Kluger Y., Ansaloni L., Carlet J., Brink A., Hardcastle T. C., Khanna A., Chicom-Mefire A., Rodriguez-Bano J., Nathwani D., Mendelson M., Watkins R. R., Pulcini C., Beovic B., May A. K., Itani K. M. F., Mazuski J. E., Fry D. E., Coccolini F., Rasxa K., Montravers P., Eckmann C., Abbo L. M., Abubakar S., Abu-Zidan F. M., Adesunkanmi A. K., Al-Hasan M. N., Althani A. A., Ticas J. E. A., Ansari S., Ansumana R., Da Silva A. R. A., Augustin G., Bala M., Balogh Z. J., Baraket O., Bassetti M., Bellanova G., Beltran M. A., Ben-Ishay O., Biffl W. L., Boermeester M. A., Brecher S. M., Bueno J., Cainzos M. A., Cairns K., Camacho-Ortiz A., Ceresoli M., Chandy S. J., Cherry-Bukowiec J. R., Cirocchi R., Colak E., Corcione A., Cornely O. A., Cortese F., Cui Y., Curcio D., Damaskos D., Dasx K., Delibegovic S., Demetrashvili Z., De Simone B., De Souza H. P., De Waele J., Dhingra S., Diaz J. J., Di Carlo I., Di Marzo F., Di Saverio S., Dogjani A., Dorj G., Dortet L., Duane T. M., Dupont H., Egiev V. N., Eid H. O., Elmangory M., El-Sayed Marei H., Enani M. A., Escandon-Vargas K., Faro M. P., Ferrada P., Foghetti D., Foianini E., Fraga G. P., Frattima S., Gandhi C., Gattuso G., Giamarellou E., Ghnnam W., Gkiokas G., Girardis M., Goff D. A., Gomes C. A., Gomi H., Gronerth R. I. G., Guirao X., Guzman-Blanco M., Haque M., Hecker A., Hell M., Herzog T., Hicks L., Kafka-Ritsch R., Kao L. S., Kanj S. S., Kaplan L. J., Kapoor G., Karamarkovic A., Kashuk J., Kenig J., Khamis F., Khokha V., Kiguba R., Kirkpatrick A. W., Korner H., Koike K., Kok K. Y. Y., Kon K., Kong V., Inaba K., Ioannidis O., Isik A., Iskandar K., Labbate M., Labricciosa F. M., Lagrou K., Lagunes L., Latifi R., Lasithiotakis K., Laxminarayan R., Lee J. G., Leone M., Leppaniemi A., Li Y., Liang S. Y., Liau K. -H., Litvin A., Loho T., Lowman W., Machain G. M., Maier R. V., Manzano-Nunez R., Marinis A., Marmorale C., Martin-Loeches I., Marwah S., Maseda E., McFarlane M., De Melo R. B., Melotti M. R., Memish Z., Mertz D., Mesina C., Menichetti F., Mishra S. K., Montori G., Moore E. E., Moore F. A., Naidoo N., Napolitano L., Negoi I., Nicolau D. P., Nikolopoulos I., Nord C. E., Ofori-Asenso R., Olaoye I., Omari A. H., Ordonez C. A., Ouadii M., Ouedraogo A. -S., Pagani L., Paiva J. A., Parreira J. G., Pata F., Pereira J., Pereira N. R., Petrosillo N., Picetti E., Pintar T., Ponce-De-Leon A., Popovski Z., Poulakou G., Preller J., Guerrero A. P., Pupelis G., Quiodettis M., Rawson T. M., Reichert M., Reinhart K., Rems M., Rello J., Rizoli S., Roberts J., Rubio-Perez I., Ruppe E., Sakakushev B., Sall I., Kafil H. S., Sanders J., Sato N., Sawyer R. G., Scalea T., Scibe R., Scudeller L., Lohse H. S., Sganga G., Shafiq N., Shah J. N., Spigaglia P., Suroowan S., Tsioutis C., Sifri C. D., Siribumrungwong B., Sugrue M., Talving P., Tan B. K., Tarasconi A., Tascini C., Tilsed J., Timsit J. -F., Tumbarello M., Trung N. T., Ulrych J., Uranues S., Velmahos G., Vereczkei A. G., Viale P., Estape J. V., Viscoli C., Wagenlehner F., Wright B. J., Xiao Y., Yuan K. -C., Zachariah S. K., Zahar J. R., Mergulhao P., and Catena F.
Abstract: This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.
Published: 2017

8. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author: Sartelli, M. Kluger, Y. Ansaloni, L. Carlet, J. Brink, A. Hardcastle, T.C. Khanna, A. Chicom-Mefire, A. Rodríguez-Baño, J. Nathwani, D. Mendelson, M. Watkins, R.R. Pulcini, C. Beović, B. May, A.K. Itani, K.M.F. Mazuski, J.E. Fry, D.E. Coccolini, F. Rasxa, K. Montravers, P. Eckmann, C. Abbo, L.M. Abubakar, S. Abu-Zidan, F.M. Adesunkanmi, A.K. Al-Hasan, M.N. Althani, A.A. Ticas, J.E.A. Ansari, S. Ansumana, R. Da Silva, A.R.A. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bassetti, M. Bellanova, G. Beltran, M.A. Ben-Ishay, O. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Bueno, J. Cainzos, M.A. Cairns, K. Camacho-Ortiz, A. Ceresoli, M. Chandy, S.J. Cherry-Bukowiec, J.R. Cirocchi, R. Colak, E. Corcione, A. Cornely, O.A. Cortese, F. Cui, Y. Curcio, D. Damaskos, D. Dasx, K. Delibegovic, S. Demetrashvili, Z. De Simone, B. De Souza, H.P. De Waele, J. Dhingra, S. Diaz, J.J. Di Carlo, I. Di Marzo, F. Di Saverio, S. Dogjani, A. Dorj, G. Dortet, L. Duane, T.M. Dupont, H. Egiev, V.N. Eid, H.O. Elmangory, M. El-Sayed Marei, H. Enani, M.A. Escandón-Vargas, K. Faro, M.P., Jr. Ferrada, P. Foghetti, D. Foianini, E. Fraga, G.P. Frattima, S. Gandhi, C. Gattuso, G. Giamarellou, E. Ghnnam, W. Gkiokas, G. Girardis, M. Goff, D.A. Gomes, C.A. Gomi, H. Gronerth, R.I.G. Guirao, X. Guzman-Blanco, M. Haque, M. Hecker, A. Hell, M. Herzog, T. Hicks, L. Kafka-Ritsch, R. Kao, L.S. Kanj, S.S. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kashuk, J. Kenig, J. Khamis, F. Khokha, V. Kiguba, R. Kirkpatrick, A.W. Kørner, H. Koike, K. Kok, K.Y.Y. Kon, K. Kong, V. Inaba, K. Ioannidis, O. Isik, A. Iskandar, K. Labbate, M. Labricciosa, F.M. Lagrou, K. Lagunes, L. Latifi, R. Lasithiotakis, K. Laxminarayan, R. Lee, J.G. Leone, M. Leppäniemi, A. Li, Y. Liang, S.Y. Liau, K.-H. Litvin, A. Loho, T. Lowman, W. Machain, G.M. Maier, R.V. Manzano-Nunez, R. Marinis, A. Marmorale, C. Martin-Loeches, I. Marwah, S. Maseda, E. McFarlane, M. De Melo, R.B. Melotti, M.R. Memish, Z. Mertz, D. Mesina, C. Menichetti, F. Mishra, S.K. Montori, G. Moore, E.E. Moore, F.A. Naidoo, N. Napolitano, L. Negoi, I. Nicolau, D.P. Nikolopoulos, I. Nord, C.E. Ofori-Asenso, R. Olaoye, I. Omari, A.H. Ordoñez, C.A. Ouadii, M. Ouedraogo, A.-S. Pagani, L. Paiva, J.A. Parreira, J.G. Pata, F. Pereira, J. Pereira, N.R. Petrosillo, N. Picetti, E. Pintar, T. Ponce-De-Leon, A. Popovski, Z. Poulakou, G. Preller, J. Guerrero, A.P. Pupelis, G. Quiodettis, M. Rawson, T.M. Reichert, M. Reinhart, K. Rems, M. Rello, J. Rizoli, S. Roberts, J. Rubio-Perez, I. Ruppé, E. Sakakushev, B. Sall, I. Kafil, H.S. Sanders, J. Sato, N. Sawyer, R.G. Scalea, T. Scibé, R. Scudeller, L. Lohse, H.S. Sganga, G. Shafiq, N. Shah, J.N. Spigaglia, P. Suroowan, S. Tsioutis, C. Sifri, C.D. Siribumrungwong, B. Sugrue, M. Talving, P. Tan, B.K. Tarasconi, A. Tascini, C. Tilsed, J. Timsit, J.-F. Tumbarello, M. Trung, N.T. Ulrych, J. Uranues, S. Velmahos, G. Vereczkei, A.G. Viale, P. Estape, J.V. Viscoli, C. Wagenlehner, F. Wright, B.J. Xiao, Y. Yuan, K.-C. Zachariah, S.K. Zahar, J.R. Mergulhão, P. Catena, F.
Abstract: This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages. © Copyright 2017, Mary Ann Liebert, Inc.
Published: 2017

9. It is time to define an organizational model for the prevention and management of infections along the surgical pathway : a worldwide cross-sectional survey

Author: Massimo Sartelli, Francesco M. Labricciosa, Federico Coccolini, Raul Coimbra, Fikri M. Abu-Zidan, Luca Ansaloni, Majdi N. Al-Hasan, Shamshul Ansari, Philip S. Barie, Miguel Angel Caínzos, Marco Ceresoli, Massimo Chiarugi, Jeffrey A. Claridge, Enrico Cicuttin, Evan Patchen Dellinger, Donald E. Fry, Xavier Guirao, Timothy Craig Hardcastle, Andreas Hecker, Ari K. Leppäniemi, Andrey Litvin, Sanjay Marwah, Emilio Maseda, John E. Mazuski, Ziad Ahmed Memish, Andrew W. Kirkpatrick, Leonardo Pagani, Mauro Podda, Huseyin Kemal Rasa, Boris E. Sakakushev, Robert G. Sawyer, Fabio Tumietto, Yonghong Xiao, Wedad Faraj Aboubreeg, Harissou Adamou, Lali Akhmeteli, Emrah Akin, Maria Grazia Alberio, Felipe Alconchel, Ibrahim Amadou Magagi, Ana Belén Araúz, Giulio Argenio, Boyko C. Atanasov, Semra Demirli Atici, Selmy Sabry Awad, Efstratia Baili, Lovenish Bains, Miklosh Bala, Oussama Baraket, Suman Baral, Vladislav A. Belskii, Moussa Benboubker, Offir Ben-Ishay, Pierpaolo Bordoni, Abdalia Boumédiène, Giuseppe Brisinda, Laura Cavazzuti, Sujith J. Chandy, Maria Michela Chiarello, Nicola Cillara, Guglielmo Clarizia, Maria-Elena Cocuz, Iuliu Gabriel Cocuz, Luigi Conti, Raffaella Coppola, Yunfeng Cui, Jacek Czepiel, Fabrizio D’Acapito, Dimitrios Damaskos, Koray Das, Belinda De Simone, Samir Delibegovic, Zaza Demetrashvili, Dzemail S. Detanac, Sameer Dhingra, Stefano Di Bella, Evgeni N. Dimitrov, Agron Dogjani, Mario D’Oria, Irina Magdalena Dumitru, Mutasim M. Elmangory, Octavian Enciu, Massimo Fantoni, Daniela Filipescu, Francesco Fleres, Domitilla Foghetti, Pietro Fransvea, Mahir Gachabayov, Rita Galeiras, Gianni Gattuso, Wagih M. Ghannam, Valeria Ghisetti, Giorgio Giraudo, Kebebe Bekele Gonfa, Emre Gonullu, Yousif Tag Elsir Y. Hamad, Matthias Hecker, Arda Isik, Nizar Ismail, Azzain Ismail, Sumita Agarwal Jain, Souha S. Kanj, Garima Kapoor, Ilias Karaiskos, Alfie J. Kavalakat, Jakub Kenig, Faryal Khamis, Vladimir Khokha, Ronald Kiguba, Jae Il Kim, Yoshiro Kobe, Kenneth Yuh Yen Kok, Bojan M. Kovacevic, Igor Andreevich Kryvoruchko, Akira Kuriyama, Aitor Landaluce-Olavarria, Konstantinos Lasithiotakis, Varut Lohsiriwat, Eftychios Lostoridis, Davide Luppi, Gustavo Miguel Machain Vega, Marc Maegele, Athanasios Marinis, Gennaro Martines, Aleix Martínez-Pérez, Damien Massalou, Cristian Mesina, Gökhan Metan, María Guadalupe Miranda-Novales, Shyam Kumar Mishra, Mohaned Ibrahim Hussein Mohamed, Ali Yasen Y. Mohamedahmed, Ismael Mora-Guzmán, Francesk Mulita, Ana-Maria Musina, Pradeep H. Navsaria, Ionut Negoi, Gabriela Elisa Nita, Donal B. O’Connor, Carlos Alberto Ordoñez, Desiré Pantalone, Arpád Panyko, Aristeidis Papadopoulos, Nikolaos Pararas, Francesco Pata, Tapan Patel, Gianluca Pellino, Teresa Perra, Gennaro Perrone, Antonio Pesce, Tadeja Pintar, Georgi Ivanov Popivanov, Alberto Porcu, Martha Alexa Quiodettis, Razrim Rahim, Ashrarur Rahman Mitul, Martin Reichert, Miran Rems, Glendee Yolande Reynolds Campbell, Nuno Rocha-Pereira, Gabriel Rodrigues, Gustavo Eduardo Roncancio Villamil, Stefano Rossi, Ibrahima Sall, Hossein Samadi Kafil, Diego Sasia, Jeremiah Seni, Charalampos Seretis, Mario Serradilla-Martín, Vishal G. Shelat, Boonying Siribumrungwong, Mihail Slavchev, Leonardo Solaini, Boun Kim Tan, Antonio Tarasconi, Dario Tartaglia, Elena Adelina Toma, Gia Tomadze, Adriana Toro, Marcos Roberto Tovani-Palone, Harry van Goor, Alin Vasilescu, Andras Vereczkei, Massimiliano Veroux, Sergio Alberto Weckmann, Lukas Werner Widmer, AliIbrahim Yahya, Sanoop K. Zachariah, Andee Dzulkarnaen Zakaria, Nadezhda Zubareva, Wietse P. Zuidema, Isidoro Di Carlo, Francesco Cortese, Gian Luca Baiocchi, Ronald V. Maier, Fausto Catena, Surgery, Other Research, AMS - Musculoskeletal Health, APH - Quality of Care, HUS Abdominal Center, II kirurgian klinikka, Sartelli M., Labricciosa F.M., Coccolini F., Coimbra R., Abu-Zidan F.M., Ansaloni L., Al-Hasan M.N., Ansari S., Barie P.S., Cainzos M.A., Ceresoli M., Chiarugi M., Claridge J.A., Cicuttin E., Dellinger E.P., Fry D.E., Guirao X., Hardcastle T.C., Hecker A., Leppaniemi A.K., Litvin A., Marwah S., Maseda E., Mazuski J.E., Memish Z.A., Kirkpatrick A.W., Pagani L., Podda M., Rasa H.K., Sakakushev B.E., Sawyer R.G., Tumietto F., Xiao Y., Aboubreeg W.F., Adamou H., Akhmeteli L., Akin E., Alberio M.G., Alconchel F., Magagi I.A., Arauz A.B., Argenio G., Atanasov B.C., Atici S.D., Awad S.S., Baili E., Bains L., Bala M., Baraket O., Baral S., Belskii V.A., Benboubker M., Ben-Ishay O., Bordoni P., Boumediene A., Brisinda G., Cavazzuti L., Chandy S.J., Chiarello M.M., Cillara N., Clarizia G., Cocuz M.-E., Cocuz I.G., Conti L., Coppola R., Cui Y., Czepiel J., D'Acapito F., Damaskos D., Das K., De Simone B., Delibegovic S., Demetrashvili Z., Detanac D.S., Dhingra S., Di Bella S., Dimitrov E.N., Dogjani A., D'Oria M., Dumitru I.M., Elmangory M.M., Enciu O., Fantoni M., Filipescu D., Fleres F., Foghetti D., Fransvea P., Gachabayov M., Galeiras R., Gattuso G., Ghannam W.M., Ghisetti V., Giraudo G., Gonfa K.B., Gonullu E., Hamad Y.T.E.Y., Hecker M., Isik A., Ismail N., Ismail A., Jain S.A., Kanj S.S., Kapoor G., Karaiskos I., Kavalakat A.J., Kenig J., Khamis F., Khokha V., Kiguba R., Kim J.I., Kobe Y., Kok K.Y.Y., Kovacevic B.M., Kryvoruchko I.A., Kuriyama A., Landaluce-Olavarria A., Lasithiotakis K., Lohsiriwat V., Lostoridis E., Luppi D., Vega G.M.M., Maegele M., Marinis A., Martines G., Martinez-Perez A., Massalou D., Mesina C., Metan G., Miranda-Novales M.G., Mishra S.K., Mohamed M.I.H., Mohamedahmed A.Y.Y., Mora-Guzman I., Mulita F., Musina A.-M., Navsaria P.H., Negoi I., Nita G.E., O'Connor D.B., Ordonez C.A., Pantalone D., Panyko A., Papadopoulos A., Pararas N., Pata F., Patel T., Pellino G., Perra T., Perrone G., Pesce A., Pintar T., Popivanov G.I., Porcu A., Quiodettis M.A., Rahim R., Mitul A.R., Reichert M., Rems M., Campbell G.Y.R., Rocha-Pereira N., Rodrigues G., Villamil G.E.R., Rossi S., Sall I., Kafil H.S., Sasia D., Seni J., Seretis C., Serradilla-Martin M., Shelat V.G., Siribumrungwong B., Slavchev M., Solaini L., Tan B.K., Tarasconi A., Tartaglia D., Toma E.A., Tomadze G., Toro A., Tovani-Palone M.R., van Goor H., Vasilescu A., Vereczkei A., Veroux M., Weckmann S.A., Widmer L.W., Yahya A.I., Zachariah S.K., Zakaria A.D., Zubareva N., Zuidema W.P., Di Carlo I., Cortese F., Baiocchi G.L., Maier R.V., Catena F., Sartelli, M, Labricciosa, F, Coccolini, F, Coimbra, R, Abu-Zidan, F, Ansaloni, L, Al-Hasan, M, Ansari, S, Barie, P, Cainzos, M, Ceresoli, M, Chiarugi, M, Claridge, J, Cicuttin, E, Dellinger, E, Fry, D, Guirao, X, Hardcastle, T, Hecker, A, Leppaniemi, A, Litvin, A, Marwah, S, Maseda, E, Mazuski, J, Memish, Z, Kirkpatrick, A, Pagani, L, Podda, M, Rasa, H, Sakakushev, B, Sawyer, R, Tumietto, F, Xiao, Y, Aboubreeg, W, Adamou, H, Akhmeteli, L, Akin, E, Alberio, M, Alconchel, F, Magagi, I, Arauz, A, Argenio, G, Atanasov, B, Atici, S, Awad, S, Baili, E, Bains, L, Bala, M, Baraket, O, Baral, S, Belskii, V, Benboubker, M, Ben-Ishay, O, Bordoni, P, Boumediene, A, Brisinda, G, Cavazzuti, L, Chandy, S, Chiarello, M, Cillara, N, Clarizia, G, Cocuz, M, Cocuz, I, Conti, L, Coppola, R, Cui, Y, Czepiel, J, D'Acapito, F, Damaskos, D, Das, K, De Simone, B, Delibegovic, S, Demetrashvili, Z, Detanac, D, Dhingra, S, Di Bella, S, Dimitrov, E, Dogjani, A, D'Oria, M, Dumitru, I, Elmangory, M, Enciu, O, Fantoni, M, Filipescu, D, Fleres, F, Foghetti, D, Fransvea, P, Gachabayov, M, Galeiras, R, Gattuso, G, Ghannam, W, Ghisetti, V, Giraudo, G, Gonfa, K, Gonullu, E, Hamad, Y, Hecker, M, Isik, A, Ismail, N, Ismail, A, Jain, S, Kanj, S, Kapoor, G, Karaiskos, I, Kavalakat, A, Kenig, J, Khamis, F, Khokha, V, Kiguba, R, Kim, J, Kobe, Y, Kok, K, Kovacevic, B, Kryvoruchko, I, Kuriyama, A, Landaluce-Olavarria, A, Lasithiotakis, K, Lohsiriwat, V, Lostoridis, E, Luppi, D, Vega, G, Maegele, M, Marinis, A, Martines, G, Martinez-Perez, A, Massalou, D, Mesina, C, Metan, G, Miranda-Novales, M, Mishra, S, Mohamed, M, Mohamedahmed, A, Mora-Guzman, I, Mulita, F, Musina, A, Navsaria, P, Negoi, I, Nita, G, O'Connor, D, Ordonez, C, Pantalone, D, Panyko, A, Papadopoulos, A, Pararas, N, Pata, F, Patel, T, Pellino, G, Perra, T, Perrone, G, Pesce, A, Pintar, T, Popivanov, G, Porcu, A, Quiodettis, M, Rahim, R, Mitul, A, Reichert, M, Rems, M, Campbell, G, Rocha-Pereira, N, Rodrigues, G, Villamil, G, Rossi, S, Sall, I, Kafil, H, Sasia, D, Seni, J, Seretis, C, Serradilla-Martin, M, Shelat, V, Siribumrungwong, B, Slavchev, M, Solaini, L, Tan, B, Tarasconi, A, Tartaglia, D, Toma, E, Tomadze, G, Toro, A, Tovani-Palone, M, van Goor, H, Vasilescu, A, Vereczkei, A, Veroux, M, Weckmann, S, Widmer, L, Yahya, A, Zachariah, S, Zakaria, A, Zubareva, N, Zuidema, W, Di Carlo, I, Cortese, F, Baiocchi, G, Maier, R, Catena, F, Sartelli, Massimo, Labricciosa, Francesco M, Coccolini, Federico, Coimbra, Raul, Abu-Zidan, Fikri M, Ansaloni, Luca, Al-Hasan, Majdi N, Ansari, Shamshul, Barie, Philip S, Caínzos, Miguel Angel, Ceresoli, Marco, Chiarugi, Massimo, Claridge, Jeffrey A, Cicuttin, Enrico, Dellinger, Evan Patchen, Fry, Donald E, Guirao, Xavier, Hardcastle, Timothy Craig, Hecker, Andrea, Leppäniemi, Ari K, Litvin, Andrey, Marwah, Sanjay, Maseda, Emilio, Mazuski, John E, Memish, Ziad Ahmed, Kirkpatrick, Andrew W, Pagani, Leonardo, Podda, Mauro, Rasa, Huseyin Kemal, Sakakushev, Boris E, Sawyer, Robert G, Tumietto, Fabio, Xiao, Yonghong, Aboubreeg, Wedad Faraj, Adamou, Harissou, Akhmeteli, Lali, Akin, Emrah, Alberio, Maria Grazia, Alconchel, Felipe, Magagi, Ibrahim Amadou, Araúz, Ana Belén, Argenio, Giulio, Atanasov, Boyko C, Atici, Semra Demirli, Awad, Selmy Sabry, Baili, Efstratia, Bains, Lovenish, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Belskii, Vladislav A, Benboubker, Moussa, Ben-Ishay, Offir, Bordoni, Pierpaolo, Boumédiène, Abdalia, Brisinda, Giuseppe, Cavazzuti, Laura, Chandy, Sujith J, Chiarello, Maria Michela, Cillara, Nicola, Clarizia, Guglielmo, Cocuz, Maria-Elena, Cocuz, Iuliu Gabriel, Conti, Luigi, Coppola, Raffaella, Cui, Yunfeng, Czepiel, Jacek, D'Acapito, Fabrizio, Damaskos, Dimitrio, Das, Koray, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Detanac, Dzemail S, Dhingra, Sameer, Di Bella, Stefano, Dimitrov, Evgeni N, Dogjani, Agron, D'Oria, Mario, Dumitru, Irina Magdalena, Elmangory, Mutasim M, Enciu, Octavian, Fantoni, Massimo, Filipescu, Daniela, Fleres, Francesco, Foghetti, Domitilla, Fransvea, Pietro, Gachabayov, Mahir, Galeiras, Rita, Gattuso, Gianni, Ghannam, Wagih M, Ghisetti, Valeria, Giraudo, Giorgio, Gonfa, Kebebe Bekele, Gonullu, Emre, Hamad, Yousif Tag Elsir Y, Hecker, Matthia, Isik, Arda, Ismail, Nizar, Ismail, Azzain, Jain, Sumita Agarwal, Kanj, Souha S, Kapoor, Garima, Karaiskos, Ilia, Kavalakat, Alfie J, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Jae Il, Kobe, Yoshiro, Kok, Kenneth Yuh Yen, Kovacevic, Bojan M, Kryvoruchko, Igor Andreevich, Kuriyama, Akira, Landaluce-Olavarria, Aitor, Lasithiotakis, Konstantino, Lohsiriwat, Varut, Lostoridis, Eftychio, Luppi, Davide, Vega, Gustavo Miguel Machain, Maegele, Marc, Marinis, Athanasio, Martines, Gennaro, Martínez-Pérez, Aleix, Massalou, Damien, Mesina, Cristian, Metan, Gökhan, Miranda-Novales, María Guadalupe, Mishra, Shyam Kumar, Mohamed, Mohaned Ibrahim Hussein, Mohamedahmed, Ali Yasen Y, Mora-Guzmán, Ismael, Mulita, Francesk, Musina, Ana-Maria, Navsaria, Pradeep H, Negoi, Ionut, Nita, Gabriela Elisa, O'Connor, Donal B, Ordoñez, Carlos Alberto, Pantalone, Desiré, Panyko, Arpád, Papadopoulos, Aristeidi, Pararas, Nikolao, Pata, Francesco, Patel, Tapan, Pellino, Gianluca, Perra, Teresa, Perrone, Gennaro, Pesce, Antonio, Pintar, Tadeja, Popivanov, Georgi Ivanov, Porcu, Alberto, Quiodettis, Martha Alexa, Rahim, Razrim, Mitul, Ashrarur Rahman, Reichert, Martin, Rems, Miran, Campbell, Glendee Yolande Reynold, Rocha-Pereira, Nuno, Rodrigues, Gabriel, Villamil, Gustavo Eduardo Roncancio, Rossi, Stefano, Sall, Ibrahima, Kafil, Hossein Samadi, Sasia, Diego, Seni, Jeremiah, Seretis, Charalampo, Serradilla-Martín, Mario, Shelat, Vishal G, Siribumrungwong, Boonying, Slavchev, Mihail, Solaini, Leonardo, Tan, Boun Kim, Tarasconi, Antonio, Tartaglia, Dario, Toma, Elena Adelina, Tomadze, Gia, Toro, Adriana, Tovani-Palone, Marcos Roberto, van Goor, Harry, Vasilescu, Alin, Vereczkei, Andra, Veroux, Massimiliano, Weckmann, Sergio Alberto, Widmer, Lukas Werner, Yahya, Aliibrahim, Zachariah, Sanoop K, Zakaria, Andee Dzulkarnaen, Zubareva, Nadezhda, Zuidema, Wietse P, Di Carlo, Isidoro, Cortese, Francesco, Baiocchi, Gian Luca, Maier, Ronald V, Catena, Fausto, Department of Medicine, and Faculty of Health Sciences
Subjects: Anti-Infective Agent, Infection prevention and control, Antibiotic resistance, Settore MED/18 - CHIRURGIA GENERALE, 610 Medicine & health, Antimicrobial stewardship, Cross-sectional survey, Antimicrobial stewardship, Antibiotic prescribing, Antibiotic resistance, Infection prevention and control, Organizational, Antibiotic prescribing, Cross-sectional survey, Anti-Infective Agents, Models, Anti-Bacterial Agent, Humans, Pandemics, Cross-Sectional Studie, ANTIMICROBIAL RESISTANCE, Pandemic, COVID-19, 3126 Surgery, anesthesiology, intensive care, radiology, Anti-Bacterial Agents, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Cross-Sectional Studies, Models, Organizational, HEALTH-CARE, Emergency Medicine, Surgery, Human
Abstract: Background The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants’ perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness. Methods A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days. Results Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for several questions regarding the prevention and management of infections in surgery. The statements may be the starting point for designing future evidence-based recommendations. Conclusion Adequacy of prevention and management of infections in acute care facilities depends on HCWs behaviours and on the organizational characteristics of acute health care facilities to support best practices and promote behavioural change. Patient involvement in the implementation of IPC is still little considered. A debate on how operationalising a fundamental change to IPC, from being solely the HCWs responsibility to one that involves a collaborative relationship between HCWs and patients, should be opened.
Published: 2022
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10. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Author: Sartelli, aEmail Author, M., Baiocchi, bEmail Author, G. L., Saverio, Di, cEmail Author, S., Ferrara, dEmail Author, F., Labricciosa, eEmail Author, F. M., Ansaloni, fEmail Author, L., Coccolini, fEmail Author, F., Vijayan, gEmail Author, D., Abbas, hEmail Author, A., Abongwa, iEmail Author, H. K., Agboola, jEmail Author, J., Ahmed, kEmail Author, A., Akhmeteli, lEmail Author, L., Akkapulu, mEmail Author, N., Akkucuk, nEmail Author, S., Altintoprak, oEmail Author, F., Andreiev, gEmail Author, A. L., Anyfantakis, pEmail Author, D., Atanasov, qEmail Author, B., Bala, rEmail Author, M., Balalis, sEmail Author, D., Baraket, tEmail Author, O., Bellanova, uEmail Author, G., Beltran, vEmail Author, M., Melo, wEmail Author, R. B., Bini, xEmail Author, R., Bouliaris, yEmail Author, K., Brunelli, zEmail Author, D., Castillo, Mario, aaEmail Author, A., Catani, abEmail Author, M., Che, Jusoh, acEmail Author, A., Chichom-Mefire, adEmail Author, A., Cocorullo, aeEmail Author, G., Coimbra, afEmail Author, R., Colak, agEmail Author, E., Costa, ahEmail Author, S., Das, aiEmail Author, K., Delibegovic, ajEmail Author, S., Demetrashvili, akEmail Author, Z., Carlo, Di, alEmail Author, I., Kiseleva, amEmail Author, N., Zalabany, El, anEmail Author, T., Faro, aoEmail Author, M., Ferreira, apEmail Author, M., Fraga, aqEmail Author, G. P., Gachabayov, arEmail Author, M., Ghnnam, asEmail Author, W. M., Giménez, Maurel, atEmail Author, T., Gkiokas, auEmail Author, G., Gomes, avEmail Author, C. A., Griffiths, awEmail Author, E., Guner, axEmail Author, A., Gupta, ayEmail Author, S., Hecker, azEmail Author, A., Hirano, aqEmail Author, E. S., Hodonou, baEmail Author, A., Hutan, bbEmail Author, M., Ioannidis, Bc, O., Bdemail, Author, Isik, beEmail Author, A., Ivakhov, bfEmail Author, G., Jain, bgEmail Author, S., Jokubauskas, bhEmail Author, M., Karamarkovic, biEmail Author, A., Kauhanen, bjEmail Author, S., Kaushik, ayEmail Author, R., Kavalakat, bkEmail Author, A., Kenig, blEmail Author, J., Khokha, bmEmail Author, V., Khor, bnEmail Author, D., Kim, aaEmail Author, D., boEmail Author, J. I., Kong, bpEmail Author, V., Lasithiotakis, bqEmail Author, K., Leão, brEmail Author, P., Leon, bsEmail Author, M., Litvin, btEmail Author, A., Lohsiriwat, buEmail Author, V., López-Tomassetti, Fernandez, bvEmail Author, E., Lostoridis, bwEmail Author, E., Maciel, aaEmail Author, J., Major, bxEmail Author, P., Dimova, byEmail Author, A., Manatakis, bzEmail Author, D., Marinis, caEmail Author, A., Martinez-Perez, cbEmail Author, A., Marwah, ccEmail Author, S., Mcfarlane, Cd, M., Ceemail, Author, Mesina, cfEmail Author, C., Pȩdziwiatr, cgEmail Author, M., Michalopoulos, chEmail Author, N., Misiakos, ciEmail Author, E., Mohamedahmed, cjEmail Author, A., Moldovanu, ckEmail Author, R., Montori, fEmail Author, G., Mysore, Narayana, clEmail Author, R., Negoi, cmEmail Author, I., Nikolopoulos, cnEmail Author, I., Novelli, coEmail Author, G., Novikovs, amEmail Author, V., Olaoye, cpEmail Author, I., Omari, cqEmail Author, A., Ordoñez, crEmail Author, C. A., Ouadii, csEmail Author, M., Ozkan, ctEmail Author, Z., Pal, cuEmail Author, A., Palini, coEmail Author, G. M., Partecke, cvEmail Author, L. I., Pata, Francesco, cwEmail Author, F., cxEmail Author, M., Pereira, Júnior, cyEmail Author, G. A., Pintar, czEmail Author, T., Pisarska, daEmail Author, M., Ploneda-Valencia, dbEmail Author, C. F., Pouggouras, bwEmail Author, K., Prabhu, dcEmail Author, V., Ramakrishnapillai, ddEmail Author, P., Regimbeau, deEmail Author, J. -M., Reitz, dfEmail Author, M., Rios-Cruz, dgEmail Author, D., Saar, dhEmail Author, S., Sakakushev, diEmail Author, B., Seretis, djEmail Author, C., Sazhin, bfEmail Author, A., Shelat, dkEmail Author, V., Skrovina, dlEmail Author, M., Smirnov, dmEmail Author, D., Spyropoulos, dnEmail Author, C., Strzałka, doEmail Author, M., Talving, dhEmail Author, P., Teixeira, Gonsaga, dpEmail Author, R. A., Theobald, gEmail Author, G., Tomadze, dqEmail Author, G., Torba, drEmail Author, M., Tranà, aEmail Author, C., Ulrych, dsEmail Author, J., Uzunoğlu, nEmail Author, M. Y., Vasilescu, dtEmail Author, A., Occhionorelli, duEmail Author, S., Venara, dvEmail Author, A., Vereczkei, dwEmail Author, A., Vettoretto, dxEmail Author, N., Vlad, dtEmail Author, N., Walȩdziak, dyEmail Author, M., Yilmaz, dzEmail Author, T. U., Yuan, eaEmail Author, K. -C., Yunfeng, ebEmail Author, C., Zilinskas, bhEmail Author, J., Grelpois, deEmail Author, G., Catena, hEmail Author, F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Universidade do Minho, Sartelli M., Abu-Zidan F.M., Labricciosa F.M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A.W., Tolonen M., Trana C., Regimbeau J.-M., Hardcastle T., Koshy R.M., Abbas A., Aday U., Adesunkanmi A.R.K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A.B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A.C., Chiarugi M., Cillara N., Cuesta R.C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G.P., Gachabayov M., Gerard G., Ghnnam W., Maurel T.G., Gkiokas G., Gomes C.A., Guner A., Gupta S., Hecker A., Hirano E.S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J.I., Kong V., Korkolis D., Kruger V.F., Kshirsagar A., Simoes R.L., Lanaia A., Lasithiotakis K., Leao P., Arellano M.L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G.M., Major P., Manatakis D., Reitz M.M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F.G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G.-E., Occhionorelli S., Olaoye I., Ordonez C.A., Ozkan Z., Pal A., Palini G.M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G.A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R.A., Tochie J.N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M.Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A.I., Yalkin O., Yilmaz T.U., Unal A.E., Yuan K.-C., Zachariah S.K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G.L., Catena F., HUS Abdominal Center, II kirurgian klinikka, University of Helsinki, İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, and Altintoprak, Fatih
Subjects: Male, Medicina Básica [Ciências Médicas], 030230 surgery, Logistic regression, 0302 clinical medicine, Injury Severity Score, Interquartile range, Risk Factors, Antibiotics, Abdomen, Diagnosis, Acute peritonitis, Early warning score, Emergency surgery, Source control, Adult, Aged, Chi-Square Distribution, Female, Hospital Mortality, Humans, Logistic Models, Middle Aged, Sepsis, Prognosis, Mortality rate, Acute peritoniti, lcsh:Medical emergencies. Critical care. Intensive care. First aid, aarly warning score, acute peritonitis, emergency surgery, source control, abdomen, adult, aged, chi-square distribution, female, hospital mortality, humans, injury severity score, logistic models, male, middle aged, risk factors, sepsis, prognosis, 3. Good health, Management, Ciências Médicas::Medicina Básica, Emergency Medicine, Research Article, Human, medicine.medical_specialty, Logistic Model, Sepsi, lcsh:Surgery, NO, 03 medical and health sciences, Internal medicine, medicine, Acute appendicitis, Science & Technology, business.industry, Risk Factor, Surgery, lcsh:RD1-811, lcsh:RC86-88.9, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, Observational study, business, Chi-squared distribution, Kidney disease
Abstract: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28–66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4–10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0–1, 22.7% for those who had scores of 2–3, 46.8% for those who had scores of 4–5, and 86.7% for those who have scores of 7–8. Conclusions The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.
Published: 2019

11. Implementation Strategies for Preventing Healthcare-Associated Infections across the Surgical Pathway: An Italian Multisociety Document.

Author: Sartelli M, Bartoli S, Borghi F, Busani S, Carsetti A, Catena F, Cillara N, Coccolini F, Cortegiani A, Cortese F, Fabbri E, Foghetti D, Forfori F, Giarratano A, Labricciosa FM, Marini P, Mastroianni C, Pan A, Pasero D, Scatizzi M, Viaggi B, and Moro ML
Abstract: Healthcare-associated infections (HAIs) result in significant patient morbidity and can prolong the duration of the hospital stay, causing high supplementary costs in addition to those already sustained due to the patient's underlying disease. Moreover, bacteria are becoming increasingly resistant to antibiotics, making HAI prevention even more important nowadays. The public health consequences of antimicrobial resistance should be constrained by prevention and control actions, which must be a priority for all health systems of the world at all levels of care. As many HAIs are preventable, they may be considered an important indicator of the quality of patient care and represent an important patient safety issue in healthcare. To share implementation strategies for preventing HAIs in the surgical setting and in all healthcare facilities, an Italian multi-society document was published online in November 2022. This article represents an evidence-based summary of the document.
Published: 2023
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12. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey.

Author: Sartelli M, Labricciosa FM, Coccolini F, Coimbra R, Abu-Zidan FM, Ansaloni L, Al-Hasan MN, Ansari S, Barie PS, Caínzos MA, Ceresoli M, Chiarugi M, Claridge JA, Cicuttin E, Dellinger EP, Fry DE, Guirao X, Hardcastle TC, Hecker A, Leppäniemi AK, Litvin A, Marwah S, Maseda E, Mazuski JE, Memish ZA, Kirkpatrick AW, Pagani L, Podda M, Rasa HK, Sakakushev BE, Sawyer RG, Tumietto F, Xiao Y, Aboubreeg WF, Adamou H, Akhmeteli L, Akin E, Alberio MG, Alconchel F, Magagi IA, Araúz AB, Argenio G, Atanasov BC, Atici SD, Awad SS, Baili E, Bains L, Bala M, Baraket O, Baral S, Belskii VA, Benboubker M, Ben-Ishay O, Bordoni P, Boumédiène A, Brisinda G, Cavazzuti L, Chandy SJ, Chiarello MM, Cillara N, Clarizia G, Cocuz ME, Cocuz IG, Conti L, Coppola R, Cui Y, Czepiel J, D'Acapito F, Damaskos D, Das K, De Simone B, Delibegovic S, Demetrashvili Z, Detanac DS, Dhingra S, Di Bella S, Dimitrov EN, Dogjani A, D'Oria M, Dumitru IM, Elmangory MM, Enciu O, Fantoni M, Filipescu D, Fleres F, Foghetti D, Fransvea P, Gachabayov M, Galeiras R, Gattuso G, Ghannam WM, Ghisetti V, Giraudo G, Gonfa KB, Gonullu E, Hamad YTEY, Hecker M, Isik A, Ismail N, Ismail A, Jain SA, Kanj SS, Kapoor G, Karaiskos I, Kavalakat AJ, Kenig J, Khamis F, Khokha V, Kiguba R, Kim JI, Kobe Y, Kok KYY, Kovacevic BM, Kryvoruchko IA, Kuriyama A, Landaluce-Olavarria A, Lasithiotakis K, Lohsiriwat V, Lostoridis E, Luppi D, Vega GMM, Maegele M, Marinis A, Martines G, Martínez-Pérez A, Massalou D, Mesina C, Metan G, Miranda-Novales MG, Mishra SK, Mohamed MIH, Mohamedahmed AYY, Mora-Guzmán I, Mulita F, Musina AM, Navsaria PH, Negoi I, Nita GE, O'Connor DB, Ordoñez CA, Pantalone D, Panyko A, Papadopoulos A, Pararas N, Pata F, Patel T, Pellino G, Perra T, Perrone G, Pesce A, Pintar T, Popivanov GI, Porcu A, Quiodettis MA, Rahim R, Mitul AR, Reichert M, Rems M, Campbell GYR, Rocha-Pereira N, Rodrigues G, Villamil GER, Rossi S, Sall I, Kafil HS, Sasia D, Seni J, Seretis C, Serradilla-Martín M, Shelat VG, Siribumrungwong B, Slavchev M, Solaini L, Tan BK, Tarasconi A, Tartaglia D, Toma EA, Tomadze G, Toro A, Tovani-Palone MR, van Goor H, Vasilescu A, Vereczkei A, Veroux M, Weckmann SA, Widmer LW, Yahya A, Zachariah SK, Zakaria AD, Zubareva N, Zuidema WP, Di Carlo I, Cortese F, Baiocchi GL, Maier RV, and Catena F
Subjects: Anti-Bacterial Agents therapeutic use, Cross-Sectional Studies, Humans, Models, Organizational, Pandemics prevention & control, Anti-Infective Agents, COVID-19
Abstract: Background: The objectives of the study were to investigate the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery; assess participants' perception regarding infection prevention and control (IPC) measures, antibiotic prescribing practices, and source control; describe awareness about the global burden of antimicrobial resistance (AMR) and IPC measures; and determine the role of the Coronavirus Disease 2019 pandemic on said awareness., Methods: A cross-sectional web-based survey was conducted contacting 1432 health care workers (HCWs) belonging to a mailing list provided by the Global Alliance for Infections in Surgery. The self-administered questionnaire was developed by a multidisciplinary team. The survey was open from May 22, 2021, and June 22, 2021. Three reminders were sent, after 7, 14, and 21 days., Results: Three hundred four respondents from 72 countries returned a questionnaire, with an overall response rate of 21.2%. Respectively, 90.4% and 68.8% of participants stated their hospital had a multidisciplinary IPC team or a multidisciplinary antimicrobial stewardship team. Local protocols for antimicrobial therapy of surgical infections and protocols for surgical antibiotic prophylaxis were present in 76.6% and 90.8% of hospitals, respectively. In 23.4% and 24.0% of hospitals no surveillance systems for surgical site infections and no monitoring systems of used antimicrobials were implemented. Patient and family involvement in IPC management was considered to be slightly or not important in their hospital by the majority of respondents (65.1%). Awareness of the global burden of AMR among HCWs was considered very important or important by 54.6% of participants. The COVID-19 pandemic was considered by 80.3% of respondents as a very important or important factor in raising HCWs awareness of the IPC programs in their hospital. Based on the survey results, the authors developed 15 statements for several questions regarding the prevention and management of infections in surgery. The statements may be the starting point for designing future evidence-based recommendations., Conclusion: Adequacy of prevention and management of infections in acute care facilities depends on HCWs behaviours and on the organizational characteristics of acute health care facilities to support best practices and promote behavioural change. Patient involvement in the implementation of IPC is still little considered. A debate on how operationalising a fundamental change to IPC, from being solely the HCWs responsibility to one that involves a collaborative relationship between HCWs and patients, should be opened., (© 2022. The Author(s).)
Published: 2022
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13. Laparoscopic Duodenal Diverticulectomy via the Inframesocolic Route.

Author: Guerra F, Foghetti D, and Patriti A
Subjects: Duodenum diagnostic imaging, Duodenum surgery, Humans, Minimally Invasive Surgical Procedures, Pancreas, Diverticulum diagnostic imaging, Diverticulum surgery, Laparoscopy
Abstract: The duodenum is traditionally reached and dissected by an anterior approach. Optimal exposure is achieved via complete hepatic flexure mobilization and kocherization of the duodenum and head of the pancreas, which can be technically challenging and time-consuming, especially in the setting of minimally invasive surgery. On the contrary, an inframesocolic approach provides a ready and neat access to the second and third segments of the duodenum with distinct advantages in terms of exposure and operative time. This video presents the details of our laparoscopic technique of approaching the duodenum via the inframesocolic route, as performed to treat a patient with symptomatic duodenal diverticulum.
Published: 2021
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14. A proposal for a comprehensive approach to infections across the surgical pathway.

Author: Sartelli M, Pagani L, Iannazzo S, Moro ML, Viale P, Pan A, Ansaloni L, Coccolini F, D'Errico MM, Agreiter I, Amadio Nespola G, Barchiesi F, Benigni V, Binazzi R, Cappanera S, Chiodera A, Cola V, Corsi D, Cortese F, Crapis M, Cristini F, D'Arpino A, De Simone B, Di Bella S, Di Marzo F, Donati A, Elisei D, Fantoni M, Ferrari A, Foghetti D, Francisci D, Gattuso G, Giacometti A, Gesuelli GC, Marmorale C, Martini E, Meledandri M, Murri R, Padrini D, Palmieri D, Pauri P, Rebagliati C, Ricchizzi E, Sambri V, Schimizzi AM, Siquini W, Scoccia L, Scoppettuolo G, Sganga G, Storti N, Tavio M, Toccafondi G, Tumietto F, Viaggi B, Vivarelli M, Tranà C, Raso M, Labricciosa FM, Dhingra S, and Catena F
Subjects: Humans, Anti-Bacterial Agents therapeutic use, Antimicrobial Stewardship, Infection Control standards, Surgical Wound Infection prevention & control
Abstract: Despite evidence supporting the effectiveness of best practices in infection prevention and management, many healthcare workers fail to implement them and evidence-based practices tend to be underused in routine practice. Prevention and management of infections across the surgical pathway should always focus on collaboration among all healthcare workers sharing knowledge of best practices. To clarify key issues in the prevention and management of infections across the surgical pathway, a multidisciplinary task force of experts convened in Ancona, Italy, on May 31, 2019, for a national meeting. This document represents the executive summary of the final statements approved by the expert panel.
Published: 2020
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15. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study.

Author: Sartelli M, Abu-Zidan FM, Labricciosa FM, Kluger Y, Coccolini F, Ansaloni L, Leppäniemi A, Kirkpatrick AW, Tolonen M, Tranà C, Regimbeau JM, Hardcastle T, Koshy RM, Abbas A, Aday U, Adesunkanmi ARK, Ajibade A, Akhmeteli L, Akın E, Akkapulu N, Alotaibi A, Altintoprak F, Anyfantakis D, Atanasov B, Augustin G, Azevedo C, Bala M, Balalis D, Baraket O, Baral S, Barkai O, Beltran M, Bini R, Bouliaris K, Caballero AB, Calu V, Catani M, Ceresoli M, Charalampakis V, Jusoh AC, Chiarugi M, Cillara N, Cuesta RC, Cobuccio L, Cocorullo G, Colak E, Conti L, Cui Y, De Simone B, Delibegovic S, Demetrashvili Z, Demetriades D, Dimova A, Dogjani A, Enani M, Farina F, Ferrara F, Foghetti D, Fontana T, Fraga GP, Gachabayov M, Gérard G, Ghnnam W, Maurel TG, Gkiokas G, Gomes CA, Guner A, Gupta S, Hecker A, Hirano ES, Hodonou A, Hutan M, Ilaschuk I, Ioannidis O, Isik A, Ivakhov G, Jain S, Jokubauskas M, Karamarkovic A, Kaushik R, Kenig J, Khokha V, Khokha D, Kim JI, Kong V, Korkolis D, Kruger VF, Kshirsagar A, Simões RL, Lanaia A, Lasithiotakis K, Leão P, Arellano ML, Listle H, Litvin A, Lizarazu Pérez A, Lopez-Tomassetti Fernandez E, Lostoridis E, Luppi D, Machain V GM, Major P, Manatakis D, Reitz MM, Marinis A, Marrelli D, Martínez-Pérez A, Marwah S, McFarlane M, Mesic M, Mesina C, Michalopoulos N, Misiakos E, Moreira FG, Mouaqit O, Muhtaroglu A, Naidoo N, Negoi I, Nikitina Z, Nikolopoulos I, Nita GE, Occhionorelli S, Olaoye I, Ordoñez CA, Ozkan Z, Pal A, Palini GM, Papageorgiou K, Papagoras D, Pata F, Pędziwiatr M, Pereira J, Pereira Junior GA, Perrone G, Pintar T, Pisarska M, Plehutsa O, Podda M, Poillucci G, Quiodettis M, Rahim T, Rios-Cruz D, Rodrigues G, Rozov D, Sakakushev B, Sall I, Sazhin A, Semião M, Sharda T, Shelat V, Sinibaldi G, Skicko D, Skrovina M, Stamatiou D, Stella M, Strzałka M, Sydorchuk R, Teixeira Gonsaga RA, Tochie JN, Tomadze G, Ugoletti L, Ulrych J, Ümarik T, Uzunoglu MY, Vasilescu A, Vaz O, Vereczkei A, Vlad N, Walędziak M, Yahya AI, Yalkin O, Yilmaz TU, Ünal AE, Yuan KC, Zachariah SK, Žilinskas J, Zizzo M, Pattonieri V, Baiocchi GL, and Catena F
Subjects: Abdomen abnormalities, Adult, Aged, Chi-Square Distribution, Female, Hospital Mortality, Humans, Injury Severity Score, Logistic Models, Male, Middle Aged, Risk Factors, Sepsis physiopathology, Abdomen physiopathology, Prognosis, Sepsis diagnosis
Abstract: Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted., Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018., Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO 2 ) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8., Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality., Competing Interests: Competing interestsThe authors declare that they have no competing interests.
Published: 2019
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15 results on '"Foghetti D."'

1. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

2. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

3. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

4. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey

5. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: A WSES observational study

6. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

7. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

8. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

9. It is time to define an organizational model for the prevention and management of infections along the surgical pathway : a worldwide cross-sectional survey

10. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

11. Implementation Strategies for Preventing Healthcare-Associated Infections across the Surgical Pathway: An Italian Multisociety Document.

12. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey.

13. Laparoscopic Duodenal Diverticulectomy via the Inframesocolic Route.

14. A proposal for a comprehensive approach to infections across the surgical pathway.

15. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study.

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