Search

Your search keyword '"Fodor, Patricia"' showing total 29 results
Start Over Author "Fodor, Patricia"
29 results on '"Fodor, Patricia"'

4. Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

Author

Wendel-Garcia, Pedro David, Moser, André, Jeitziner, Marie-Madlen, Aguirre-Bermeo, Hernán, Arias-Sanchez, Pedro, Apolo, Janina, Roche-Campo, Ferran, Franch-Llasat, Diego, Kleger, Gian-Reto, Schrag, Claudia, Pietsch, Urs, Filipovic, Miodrag, David, Sascha, Stahl, Klaus, Bouaoud, Souad, Ouyahia, Amel, Fodor, Patricia, Locher, Pascal, Siegemund, Martin, Zellweger, Nuria, Cereghetti, Sara, Schott, Peter, Gangitano, Gianfilippo, Wu, Maddalena Alessandra, Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Ksouri, Hatem, Gehring, Nadine, Rezoagli, Emanuele, Turrini, Fabrizio, Lozano-Gómez, Herminia, Carsetti, Andrea, Rodríguez-García, Raquel, Yuen, Bernd, Weber, Anja Baltussen, Castro, Pedro, Escos-Orta, Jesus Oscar, Dullenkopf, Alexander, Martín-Delgado, Maria C., Aslanidis, Theodoros, Perez, Marie-Helene, Hillgaertner, Frank, Ceruti, Samuele, Franchitti Laurent, Marilene, Marrel, Julien, Colombo, Riccardo, Laube, Marcus, Fogagnolo, Alberto, Studhalter, Michael, Wengenmayer, Tobias, Gamberini, Emiliano, Buerkle, Christian, Buehler, Philipp K., Keiser, Stefanie, Elhadi, Muhammed, Montomoli, Jonathan, Guerci, Philippe, Fumeaux, Thierry, Schuepbach, Reto A., Jakob, Stephan M., Que, Yok-Ai, and Hilty, Matthias Peter

Published
2022
Full Text
View/download PDF

5. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Aguirre-Bermeo, Hernán, Apolo, Janina, Martínez, Alberto, Jurkolow, Geoffrey, Delahaye, Gauthier, Novy, Emmanuel, Losser, Marie-Reine, Wengenmayer, Tobias, Rilinger, Jonathan, Staudacher, Dawid L., David, Sascha, Welte, Tobias, Stahl, Klaus, Pavlos”, “Agios, Aslanidis, Theodoros, Korsos, Anita, Babik, Barna, Nikandish, Reza, Rezoagli, Emanuele, Giacomini, Matteo, Nova, Alice, Fogagnolo, Alberto, Spadaro, Savino, Ceriani, Roberto, Murrone, Martina, Wu, Maddalena A., Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Turrini, Fabrizio, Simonini, Maria Sole, Fabbri, Silvia, Potalivo, Antonella, Facondini, Francesca, Gangitano, Gianfilippo, Perin, Tiziana, Grazia Bocci, Maria, Antonelli, Massimo, Gommers, Diederik, Rodríguez-García, Raquel, Gámez-Zapata, Jorge, Taboada-Fraga, Xiana, Castro, Pedro, Tellez, Adrian, Lander-Azcona, Arantxa, Escós-Orta, Jesús, Martín-Delgado, Maria C., Algaba-Calderon, Angela, Franch-Llasat, Diego, Roche-Campo, Ferran, Lozano-Gómez, Herminia, Zalba-Etayo, Begoña, Michot, Marc P., Klarer, Alexander, Ensner, Rolf, Schott, Peter, Urech, Severin, Zellweger, Nuria, Merki, Lukas, Lambert, Adriana, Laube, Marcus, Jeitziner, Marie M., Jenni-Moser, Beatrice, Wiegand, Jan, Yuen, Bernd, Lienhardt-Nobbe, Barbara, Westphalen, Andrea, Salomon, Petra, Drvaric, Iris, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Chau, Ivan, Ksouri, Hatem, Sridharan, Govind Oliver, Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Grazioli, Serge, Rimensberger, Peter C., Bürkle, Christian, Marrel, Julien, Brenni, Mirko, Fleisch, Isabelle, Lavanchy, Jerome, Perez, Marie-Helene, Ramelet, Anne-Sylvie, Weber, Anja Baltussen, Gerecke, Peter, Christ, Andreas, Ceruti, Samuele, Glotta, Andrea, Marquardt, Katharina, Shaikh, Karim, Hübner, Tobias, Neff, Thomas, Redecker, Hermann, Moret-Bochatay, Mallory, Bentrup, FriederikeMeyer zu, Studhalter, Michael, Stephan, Michael, Brem, Jan, Gehring, Nadine, Selz, Daniela, Naon, Didier, Kleger, Gian-Reto, Pietsch, Urs, Filipovic, Miodrag, Ristic, Anette, Sepulcri, Michael, Heise, Antje, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Wendel Garcia, Pedro D., Schuepbach, Reto, Heuberger, Dorothea, Bühler, Philipp, Brugger, Silvio, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Gaspert, Tomislav, Jovic, Marija, Haberthuer, Christoph, Lussman, Roger F., Colak, Elif, Montomoli, Jonathan, Romeo, Luca, Moccia, Sara, Bernardini, Michele, Migliorelli, Lucia, Berardini, Daniele, Donati, Abele, Carsetti, Andrea, Bocci, Maria Grazia, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Schüpbach, Reto Andreas, Ince, Can, Frontoni, Emanuele, and Hilty, Matthias Peter

Published
2021
Full Text
View/download PDF

6. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Alfaro Farias, Mario, Margarit, Antoni, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Cardona, Francesco S., Skola, Josef, Horakova, Lenka, Aguirre-Bermeo, Hernan, Apolo, Janina, Novy, Emmanuel, Losser, Marie-Reine, Jurkolow, Geoffrey, Delahaye, Gauthier, David, Sascha, Welte, Tobias, Wengenmayer, Tobias, Staudacher, Dawid L., Aslanidis, Theodoros, Babik, Barna, Korsos, Anita, Gal, Janos, Csaba, Hermann, Donati, Abele, Carsetti, Andrea, Turrini, Fabrizio, Simonini, Maria Sole, Ceriani, Roberto, Murrone, Martina, Rezoagli, Emanuele, Vitale, Giovanni, Fogagnolo, Alberto, Spadaro, Savino, Wu, Maddalena Alessandra, Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Facondini, Francesca, Potalivo, Antonella, Gangitano, Gianfilippo, Perin, Tiziana, Bocci, Maria Grazia, Antonelli, Massimo, Gommers, Diederik, Ince, Can, Mayor-Vázquez, Eric, Cruz, Maria, Delgado, Martin, Garcia, Raquel Rodriguez, Gamez Zapata, Jorge, Zalba-Etayo, Begoña, Lozano-Gomez, Herminia, Castro, Pedro, Tellez, Adrian, Jacas, Adriana, Muñoz, Guido, Andrea, Rut, Ortiz, Jose, Quintana, Eduard, Rovira, Irene, Reverter, Enric, Fernandez, Javier, Ferrer, Miquel, Badia, Joan R., Lander Azcona, Arantxa, Orta, Jesus Escos, Bühler, Philipp, Brugger, Silvio, Hofmaenner, Daniel, Unseld, Simone, Ruschitzka, Frank, Moret-Bochatay, Mallory, Yuen, Bernd, Hillermann, Thomas, Ksouri, Hatem, Sridharan, Govind Oliver, Ristic, Anette, Sepulcri, Michael, Filipovic, Miodrag, Pietsch, Urs, Salomon, Petra, Drvaric, Iris, Schott, Peter, Urech, Severin, Lambert, Adriana, Merki, Lukas, Laube, Marcus, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Grazioli, Serge, Rimensberger, Peter C., Fleisch, Isabelle, Lavanchy, Jerome, Marquardt, Katharina, Shaikh, Karim, Redecker, Hermann, Stephan, Michael, Brem, Jan, Rogdo, Bjarte, Birkenmaier, Andre, Meyer zu Bentrup, Friederike, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Siegemund, Martin, Zellweger, Nuria, Jeitziner, Marie-Madlen, Jenni-Moser, Beatrice, Bürkle, Christian, Kleger, Gian-Reto, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Gaspert, Tomislav, Jovic, Marija, Studhalter, Michael, Haberthuer, Christoph, Lussman, Roger F., Selz, Daniela, Naon, Didier, Mauri, Romano, Ceruti, Samuele, Marrel, Julien, Brenni, Mirko, Ensner, Rolf, Gehring, Nadine, Heise, Antje, Huebner, Tobias, Neff, Thomas A., Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Marczin, Nandor, Wong, Joyce, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Heuberger, Dorothea Monika, Montomoli, Jonathan, Roche-Campo, Ferran, Schuepbach, Reto Andreas, and Hilty, Matthias Peter

Published
2020
Full Text
View/download PDF

7. Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial

Author

Beck-Schimmer, Beatrice; https://orcid.org/0000-0002-0648-6115, Schadde, Erik; https://orcid.org/0000-0003-4561-6469, Pietsch, Urs; https://orcid.org/0000-0001-6957-2638, Filipovic, Miodrag, Dübendorfer-Dalbert, Seraina, Fodor, Patricia, Hübner, Tobias, Schuepbach, Reto; https://orcid.org/0000-0002-7058-4377, Steiger, Peter; https://orcid.org/0000-0002-3617-5174, David, Sascha; https://orcid.org/0000-0002-8231-0461, Krüger, Bernard D, Neff, Thomas A, Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124, Beck-Schimmer, Beatrice; https://orcid.org/0000-0002-0648-6115, Schadde, Erik; https://orcid.org/0000-0003-4561-6469, Pietsch, Urs; https://orcid.org/0000-0001-6957-2638, Filipovic, Miodrag, Dübendorfer-Dalbert, Seraina, Fodor, Patricia, Hübner, Tobias, Schuepbach, Reto; https://orcid.org/0000-0002-7058-4377, Steiger, Peter; https://orcid.org/0000-0002-3617-5174, David, Sascha; https://orcid.org/0000-0002-8231-0461, Krüger, Bernard D, Neff, Thomas A, and Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124

Abstract

Background This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. Methods This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs. continuous intravenous sedation (= control) within 24 h after intubation. The primary composite outcome was determined as mortality or persistent organ dysfunction (POD), defined as the need for mechanical ventilation, vasopressors, or renal replacement therapy at day 28. Secondary outcomes were the length of ICU and hospital stay, adverse events, routine laboratory parameters (creatinine, urea), and plasma inflammatory mediators. Results 28 patients were randomized to sevoflurane, 32 to the control arm. The intention-to-treat analysis revealed no difference in the primary endpoint with 11 (39%) sevoflurane and 13 (41%) control patients (p = 0.916) reaching the primary outcome. Five patients died within 28 days in each group (16% vs. 18%, p = 0.817). Of the 28-day survivors, 6 (26%) and 8 (30%) presented with POD (p = 0.781). There was a significant difference regarding the need for vasopressors (1 (4%) patient in the sevoflurane arm, 7 (26%) in the control one (p = 0.028)). Length of ICU stay, hospital stay, and registered adverse events within 28 days were comparable, except for acute kidney injury (AKI), with 11 (39%) sevoflurane vs. 2 (6%) control patients (p = 0.001). The blood levels of IL-6 in the first few days after the onset of the lung injury were less distinctly elevated than expected. Conclusions No evident benefits were observed with short sev

Published
2024

8. Effects of enhanced adsorption haemofiltration versus haemoadsorption in severe, refractory septic shock with high levels of endotoxemia: the ENDoX bicentric, randomized, controlled trial

Author

Wendel-Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279, Eberle, Barbara, Kleinert, Eva-Maria, Hilty, Matthias Peter, Blumenthal, Stephan, Spanaus, Katharina, Fodor, Patricia, Maggiorini, Marco, Wendel-Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279, Eberle, Barbara, Kleinert, Eva-Maria, Hilty, Matthias Peter, Blumenthal, Stephan, Spanaus, Katharina, Fodor, Patricia, and Maggiorini, Marco

Abstract

Background Endotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the effective capacity of available devices to reduce circulating endotoxin and inflammatory cytokine levels. Methods Multiarm, randomized, controlled trial in two Swiss intensive care units, with a 1:1:1 randomization of patients suffering severe, refractory septic shock with high levels of endotoxemia, defined as an endotoxin activity ≥ 0.6, a vasopressor dependency index ≥ 3, volume resuscitation of at least 30 ml/kg/24 h and at least single organ failure, to a haemoadsorption (Toraymyxin), an enhanced adsorption haemofiltration (oXiris) or a control intervention. Primary endpoint was the difference in endotoxin activity at 72-h post-intervention to baseline. In addition, inflammatory cytokine, vasopressor dependency index and SOFA-Score dynamics over the initial 72 h were assessed inter alia. Results In the 30, out of 437 screened, randomized patients (10 Standard of care, 10 oXiris, 10 Toraymyxin), endotoxin reduction at 72-h post-intervention-start did not differ among interventions (Standard of Care: 12 [1–42]%, oXiris: 21 [10–51]%, Toraymyxin: 23 [10–36]%, p = 0.82). Furthermore, no difference between groups could be observed neither for reduction of inflammatory cytokine levels (p = 0.58), nor for vasopressor weaning (p = 0.95) or reversal of organ injury (p = 0.22). Conclusions In a highly endotoxemic, severe, refractory septic shock population neither the Toraymyxin adsorber nor the oXiris membrane could show a reduction in circulating endotoxin or cytokine levels over standard of care.

Published
2023

9. Additional file 1 of Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

Author

Wendel-Garcia, Pedro David, Moser, André, Jeitziner, Marie-Madlen, Aguirre-Bermeo, Hernán, Arias-Sanchez, Pedro, Apolo, Janina, Roche-Campo, Ferran, Franch-Llasat, Diego, Kleger, Gian-Reto, Schrag, Claudia, Pietsch, Urs, Filipovic, Miodrag, David, Sascha, Stahl, Klaus, Bouaoud, Souad, Ouyahia, Amel, Fodor, Patricia, Locher, Pascal, Siegemund, Martin, Zellweger, Nuria, Cereghetti, Sara, Schott, Peter, Gangitano, Gianfilippo, Wu, Maddalena Alessandra, Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Ksouri, Hatem, Gehring, Nadine, Rezoagli, Emanuele, Turrini, Fabrizio, Lozano-Gómez, Herminia, Carsetti, Andrea, Rodríguez-García, Raquel, Yuen, Bernd, Weber, Anja Baltussen, Castro, Pedro, Escos-Orta, Jesus Oscar, Dullenkopf, Alexander, Martín-Delgado, Maria C., Aslanidis, Theodoros, Perez, Marie-Helene, Hillgaertner, Frank, Ceruti, Samuele, Franchitti Laurent, Marilene, Marrel, Julien, Colombo, Riccardo, Laube, Marcus, Fogagnolo, Alberto, Studhalter, Michael, Wengenmayer, Tobias, Gamberini, Emiliano, Buerkle, Christian, Buehler, Philipp K., Keiser, Stefanie, Elhadi, Muhammed, Montomoli, Jonathan, Guerci, Philippe, Fumeaux, Thierry, Schuepbach, Reto A., Jakob, Stephan M., Que, Yok-Ai, and Hilty, Matthias Peter

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1. Online Supplementary Material.

Published
2022
Full Text
View/download PDF

11. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Montomoli, Jonathan, primary, Romeo, Luca, additional, Moccia, Sara, additional, Bernardini, Michele, additional, Migliorelli, Lucia, additional, Berardini, Daniele, additional, Donati, Abele, additional, Carsetti, Andrea, additional, Bocci, Maria Grazia, additional, Wendel Garcia, Pedro David, additional, Fumeaux, Thierry, additional, Guerci, Philippe, additional, Schüpbach, Reto Andreas, additional, Ince, Can, additional, Frontoni, Emanuele, additional, Hilty, Matthias Peter, additional, Alfaro-Farias, Mario, additional, Vizmanos-Lamotte, Gerardo, additional, Tschoellitsch, Thomas, additional, Meier, Jens, additional, Aguirre-Bermeo, Hernán, additional, Apolo, Janina, additional, Martínez, Alberto, additional, Jurkolow, Geoffrey, additional, Delahaye, Gauthier, additional, Novy, Emmanuel, additional, Losser, Marie-Reine, additional, Wengenmayer, Tobias, additional, Rilinger, Jonathan, additional, Staudacher, Dawid L., additional, David, Sascha, additional, Welte, Tobias, additional, Stahl, Klaus, additional, Pavlos”, “Agios, additional, Aslanidis, Theodoros, additional, Korsos, Anita, additional, Babik, Barna, additional, Nikandish, Reza, additional, Rezoagli, Emanuele, additional, Giacomini, Matteo, additional, Nova, Alice, additional, Fogagnolo, Alberto, additional, Spadaro, Savino, additional, Ceriani, Roberto, additional, Murrone, Martina, additional, Wu, Maddalena A., additional, Cogliati, Chiara, additional, Colombo, Riccardo, additional, Catena, Emanuele, additional, Turrini, Fabrizio, additional, Simonini, Maria Sole, additional, Fabbri, Silvia, additional, Potalivo, Antonella, additional, Facondini, Francesca, additional, Gangitano, Gianfilippo, additional, Perin, Tiziana, additional, Grazia Bocci, Maria, additional, Antonelli, Massimo, additional, Gommers, Diederik, additional, Rodríguez-García, Raquel, additional, Gámez-Zapata, Jorge, additional, Taboada-Fraga, Xiana, additional, Castro, Pedro, additional, Tellez, Adrian, additional, Lander-Azcona, Arantxa, additional, Escós-Orta, Jesús, additional, Martín-Delgado, Maria C., additional, Algaba-Calderon, Angela, additional, Franch-Llasat, Diego, additional, Roche-Campo, Ferran, additional, Lozano-Gómez, Herminia, additional, Zalba-Etayo, Begoña, additional, Michot, Marc P., additional, Klarer, Alexander, additional, Ensner, Rolf, additional, Schott, Peter, additional, Urech, Severin, additional, Zellweger, Nuria, additional, Merki, Lukas, additional, Lambert, Adriana, additional, Laube, Marcus, additional, Jeitziner, Marie M., additional, Jenni-Moser, Beatrice, additional, Wiegand, Jan, additional, Yuen, Bernd, additional, Lienhardt-Nobbe, Barbara, additional, Westphalen, Andrea, additional, Salomon, Petra, additional, Drvaric, Iris, additional, Hillgaertner, Frank, additional, Sieber, Marianne, additional, Dullenkopf, Alexander, additional, Petersen, Lina, additional, Chau, Ivan, additional, Ksouri, Hatem, additional, Sridharan, Govind Oliver, additional, Cereghetti, Sara, additional, Boroli, Filippo, additional, Pugin, Jerome, additional, Grazioli, Serge, additional, Rimensberger, Peter C., additional, Bürkle, Christian, additional, Marrel, Julien, additional, Brenni, Mirko, additional, Fleisch, Isabelle, additional, Lavanchy, Jerome, additional, Perez, Marie-Helene, additional, Ramelet, Anne-Sylvie, additional, Weber, Anja Baltussen, additional, Gerecke, Peter, additional, Christ, Andreas, additional, Ceruti, Samuele, additional, Glotta, Andrea, additional, Marquardt, Katharina, additional, Shaikh, Karim, additional, Hübner, Tobias, additional, Neff, Thomas, additional, Redecker, Hermann, additional, Moret-Bochatay, Mallory, additional, Bentrup, FriederikeMeyer zu, additional, Studhalter, Michael, additional, Stephan, Michael, additional, Brem, Jan, additional, Gehring, Nadine, additional, Selz, Daniela, additional, Naon, Didier, additional, Kleger, Gian-Reto, additional, Pietsch, Urs, additional, Filipovic, Miodrag, additional, Ristic, Anette, additional, Sepulcri, Michael, additional, Heise, Antje, additional, Franchitti Laurent, Marilene, additional, Laurent, Jean-Christophe, additional, Wendel Garcia, Pedro D., additional, Schuepbach, Reto, additional, Heuberger, Dorothea, additional, Bühler, Philipp, additional, Brugger, Silvio, additional, Fodor, Patricia, additional, Locher, Pascal, additional, Camen, Giovanni, additional, Gaspert, Tomislav, additional, Jovic, Marija, additional, Haberthuer, Christoph, additional, Lussman, Roger F., additional, and Colak, Elif, additional

Published
2021
Full Text
View/download PDF

12. Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Author

Wendel Garcia, Pedro D, Aguirre-Bermeo, Hernán, Buehler, Philipp K, Alfaro-Farias, Mario, Yuen, Bernd, David, Sascha, Tschoellitsch, Thomas, Wengenmayer, Tobias, Korsos, Anita, Fogagnolo, Alberto, Kleger, Gian-Reto, Wu, Maddalena A, Colombo, Riccardo, Turrini, Fabrizio, Potalivo, Antonella, Rezoagli, Emanuele, Rodríguez-García, Raquel, Castro, Pedro, Lander-Azcona, Arantxa, Martín-Delgado, Maria C, Lozano-Gómez, Herminia, Ensner, Rolf, Michot, Marc P, Gehring, Nadine, Schott, Peter, Siegemund, Martin, Merki, Lukas, Wiegand, Jan, Jeitziner, Marie M, Laube, Marcus, Fodor, Patricia, et al, and University of Zurich

Subjects
10234 Clinic for Infectious Diseases, 610 Medicine & health, 10023 Institute of Intensive Care Medicine, 2706 Critical Care and Intensive Care Medicine
Published
2021
Full Text
View/download PDF

13. Prevalence of hypophosphatemia in the ICU – Results of an international one-day point prevalence survey

Author

Viana Marina Verçoza, Simpson Shannon, Pereira Fernando, Rosenfeld Ricardo, Jaber Samir, Michael P Casaer, Krol Tim, Joannes-Boyau Olivier, Mette M. Berger, Fumeaux Thierry, Cheng Meisy Pérez, Reintam Blaser Annika, Pérez Gema, Karu Inga, Martinez-Alejos Roberto, A. Reintam-Blaser, Duska Frantisek, Jain Nikilesh, Alberts Erna, Samat Noryani, M. Berger Mette, Deepak Swarna, Gurjar Mohan, Jan Gunst, Kuhn Karl Friedrich, Laube Marcus, Stefan J. Schaller, Pfortmuller Carmen, Jung Veronika, Gunst Jan, Jammer Ib, Kursat Gundogan, Grand Hubert, Joel Starkopf, Keryakos Hesham Kamal Habeeb, Morris Andrew Conway, Malbrain Manu, O. Appelberg, Straka Kelly, Perez Marie-Helene, Kleger Gian-Reto, Besch Guillaume, Manrique Ezequiel, Fodor Patricia, Ichai Carole, Launey Yoann, Nicolas Mongardon, Constantin Jean-Michel, O. Joannes-Boyau, Fuest Kristina, J. Schaller Stefan, Jamme Matthieu, Marrel Julien, Van Zanten Arthur, Casaer Michael, Huq Shihan, M.E. de Man Angelique, C. Ichai, Szakmany Tamas, Tamme Kadri, Heyer Laurent, Besançon Bodolea Costel, Islam Motiul, Arroyo Abel, and Pahuja Madhu

Subjects
0301 basic medicine, Point prevalence survey, Adult, medicine.medical_specialty, Icu patients, Monitoring, Adolescent, Hypophosphatemia, Critical Care and Intensive Care Medicine, Nutrition and Dietetics, 030209 endocrinology & metabolism, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Electrolyte, medicine, Prevalence, Humans, Icu stay, Critically ill, Child, Nutrition, Aged, Aged, 80 and over, Repletion, 030109 nutrition & dietetics, business.industry, Organ dysfunction, Middle Aged, medicine.disease, Blood phosphate, Unexpected finding, Intensive Care Units, Plasma phosphate, Cross-Sectional Studies, Emergency medicine, medicine.symptom, business, Standard operating procedure
Abstract

BACKGROUND & AIMS: Hypophosphatemia (HypoP) is associated with organ dysfunction and mortality. Despite its potential severe consequences, HypoP remains poorly characterized in terms of real prevalence and timing of onset. The primary objective was to determine the prevalence of HypoP defined as blood phosphate

Published
2021

15. Additional file 1 of Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Author

Garcia, Pedro D. Wendel, Aguirre-Bermeo, Hernán, Buehler, Philipp K., Alfaro-Farias, Mario, Yuen, Bernd, David, Sascha, Tschoellitsch, Thomas, Wengenmayer, Tobias, Korsos, Anita, Fogagnolo, Alberto, Gian-Reto Kleger, Wu, Maddalena A., Colombo, Riccardo, Turrini, Fabrizio, Potalivo, Antonella, Rezoagli, Emanuele, Rodríguez-García, Raquel, Castro, Pedro, Lander-Azcona, Arantxa, Martín-Delgado, Maria C., Lozano-Gómez, Herminia, Ensner, Rolf, Michot, Marc P., Gehring, Nadine, Schott, Peter, Siegemund, Martin, Merki, Lukas, Wiegand, Jan, Jeitziner, Marie M., Laube, Marcus, Salomon, Petra, Hillgaertner, Frank, Dullenkopf, Alexander, Ksouri, Hatem, Cereghetti, Sara, Grazioli, Serge, Bürkle, Christian, Marrel, Julien, Fleisch, Isabelle, Marie-Helene Perez, Weber, Anja Baltussen, Ceruti, Samuele, Marquardt, Katharina, Hübner, Tobias, Redecker, Hermann, Studhalter, Michael, Stephan, Michael, Selz, Daniela, Pietsch, Urs, Ristic, Anette, Heise, Antje, Bentrup, Friederike Meyer Zu, Laurent, Marilene Franchitti, Fodor, Patricia, Gaspert, Tomislav, Haberthuer, Christoph, Colak, Elif, Heuberger, Dorothea M., Fumeaux, Thierry, Montomoli, Jonathan, Guerci, Philippe, Schuepbach, Reto A., Hilty, Matthias P., and Roche-Campo, Ferran

Abstract

Additional file 1. e-Appendix 1: Specifications on the RISC-19-ICU registry structure and data collection. e-Appendix 2: Missing data handling. e-Table 1: Overall “unmatched” baseline characteristics on Day 0. e-Figure 1: “Love Plot” presenting Standardized Mean Differences between the unmatched and matchedcohort. e-Table 2: Demographics, characteristics at ICU admission, progression of respiratory support and outcome; stratified by survivor status. e-Table 3: Progression of respiratory support stratified by respiratory support strategy at ICU admission. e-Figure 2: Temporal relationship between the period of admission to the intensive care unit and the use of respiratory support strategies or mortality rate. e-Figure 3: Kaplan Meier curves for intensive care unit mortality stratified by the period of admission to the intensive care unit. e-Table 4: Demographics, characteristics at ICU admission, progression of respiratory support and outcome for patients never requiring intubation and invasive mechanical ventilation. e-Figure 4: C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Table 5: Mixed Effect Model of C-Reactive Protein stratified by respiratory support strategy on Day 0 over the first week of ICU stay. e-Figure 5: Multivariable adjusted COX regression model for the incidence of intubation. e-Figure 6: Multivariable adjusted COX regression model for overall ICU mortality. e-Figure 7: Multivariable adjusted COX regression model for ICU mortality (intubated patients only). e-Figure 8: Multivariable adjusted COX regression model for ICU discharge (intubated patients only). e-Table 6: Prognostic Model for the identification of patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Figure 9: Nomogram, Receiver Operating Curves and stratified Kaplan Meier curve for a prognostic model identifying patients with lower ICU mortality risk after a failed HFNC or NIV trial. e-Table 7: Area Under the Receiver Operating Curves (AUROCs) for the Prognostic Score versus classic severity scores.

Published
2021
Full Text
View/download PDF

19. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Wendel Garcia, Pedro David, primary, Fumeaux, Thierry, additional, Guerci, Philippe, additional, Heuberger, Dorothea Monika, additional, Montomoli, Jonathan, additional, Roche-Campo, Ferran, additional, Schuepbach, Reto Andreas, additional, Hilty, Matthias Peter, additional, Alfaro Farias, Mario, additional, Margarit, Antoni, additional, Vizmanos-Lamotte, Gerardo, additional, Tschoellitsch, Thomas, additional, Meier, Jens, additional, Cardona, Francesco S., additional, Skola, Josef, additional, Horakova, Lenka, additional, Aguirre-Bermeo, Hernan, additional, Apolo, Janina, additional, Novy, Emmanuel, additional, Losser, Marie-Reine, additional, Jurkolow, Geoffrey, additional, Delahaye, Gauthier, additional, David, Sascha, additional, Welte, Tobias, additional, Wengenmayer, Tobias, additional, Staudacher, Dawid L., additional, Aslanidis, Theodoros, additional, Babik, Barna, additional, Korsos, Anita, additional, Gal, Janos, additional, Csaba, Hermann, additional, Donati, Abele, additional, Carsetti, Andrea, additional, Turrini, Fabrizio, additional, Simonini, Maria Sole, additional, Ceriani, Roberto, additional, Murrone, Martina, additional, Rezoagli, Emanuele, additional, Vitale, Giovanni, additional, Fogagnolo, Alberto, additional, Spadaro, Savino, additional, Wu, Maddalena Alessandra, additional, Cogliati, Chiara, additional, Colombo, Riccardo, additional, Catena, Emanuele, additional, Facondini, Francesca, additional, Potalivo, Antonella, additional, Gangitano, Gianfilippo, additional, Perin, Tiziana, additional, Bocci, Maria Grazia, additional, Antonelli, Massimo, additional, Gommers, Diederik, additional, Ince, Can, additional, Mayor-Vázquez, Eric, additional, Cruz, Maria, additional, Delgado, Martin, additional, Garcia, Raquel Rodriguez, additional, Gamez Zapata, Jorge, additional, Zalba-Etayo, Begoña, additional, Lozano-Gomez, Herminia, additional, Castro, Pedro, additional, Tellez, Adrian, additional, Jacas, Adriana, additional, Muñoz, Guido, additional, Andrea, Rut, additional, Ortiz, Jose, additional, Quintana, Eduard, additional, Rovira, Irene, additional, Reverter, Enric, additional, Fernandez, Javier, additional, Ferrer, Miquel, additional, Badia, Joan R., additional, Lander Azcona, Arantxa, additional, Orta, Jesus Escos, additional, Bühler, Philipp, additional, Brugger, Silvio, additional, Hofmaenner, Daniel, additional, Unseld, Simone, additional, Ruschitzka, Frank, additional, Moret-Bochatay, Mallory, additional, Yuen, Bernd, additional, Hillermann, Thomas, additional, Ksouri, Hatem, additional, Sridharan, Govind Oliver, additional, Ristic, Anette, additional, Sepulcri, Michael, additional, Filipovic, Miodrag, additional, Pietsch, Urs, additional, Salomon, Petra, additional, Drvaric, Iris, additional, Schott, Peter, additional, Urech, Severin, additional, Lambert, Adriana, additional, Merki, Lukas, additional, Laube, Marcus, additional, Hillgaertner, Frank, additional, Sieber, Marianne, additional, Dullenkopf, Alexander, additional, Petersen, Lina, additional, Grazioli, Serge, additional, Rimensberger, Peter C., additional, Fleisch, Isabelle, additional, Lavanchy, Jerome, additional, Marquardt, Katharina, additional, Shaikh, Karim, additional, Redecker, Hermann, additional, Stephan, Michael, additional, Brem, Jan, additional, Rogdo, Bjarte, additional, Birkenmaier, Andre, additional, Meyer zu Bentrup, Friederike, additional, Fodor, Patricia, additional, Locher, Pascal, additional, Camen, Giovanni, additional, Siegemund, Martin, additional, Zellweger, Nuria, additional, Jeitziner, Marie-Madlen, additional, Jenni-Moser, Beatrice, additional, Bürkle, Christian, additional, Kleger, Gian-Reto, additional, Franchitti Laurent, Marilene, additional, Laurent, Jean-Christophe, additional, Gaspert, Tomislav, additional, Jovic, Marija, additional, Studhalter, Michael, additional, Haberthuer, Christoph, additional, Lussman, Roger F., additional, Selz, Daniela, additional, Naon, Didier, additional, Mauri, Romano, additional, Ceruti, Samuele, additional, Marrel, Julien, additional, Brenni, Mirko, additional, Ensner, Rolf, additional, Gehring, Nadine, additional, Heise, Antje, additional, Huebner, Tobias, additional, Neff, Thomas A., additional, Cereghetti, Sara, additional, Boroli, Filippo, additional, Pugin, Jerome, additional, Marczin, Nandor, additional, and Wong, Joyce, additional

Published
2020
Full Text
View/download PDF

20. Impact of postoperative hypothermia on outcomes after off-pump coronary artery bypass grafting.

Author

Ntinopoulos, Vasileios, Papadopoulos, Nestoras, Haeussler, Achim, Odavic, Dragan, Fodor, Patricia, and Dzemali, Omer

Abstract

Background: Even though the physiological derangements caused by hypothermia are well described, there is no consensus about its impact on postoperative outcomes. The aim of this study is to assess the effect of postoperative hypothermia on outcomes after off-pump coronary artery bypass surgery. Methods: A total of 1979 patients undergoing isolated off-pump coronary artery bypass surgery in a single center in the period 2007–2018 were classified according to their axillary temperature measurement at intensive care unit admission postoperatively to either hypothermic (<36°C) or normothermic (≥36°C). Between-group differences on baseline characteristics and postoperative outcomes were assessed before and after propensity score matching. Results: Data analysis showed that 582 patients (29.4%) were hypothermic (median temperature 35.5°C) and 1397 patients (70.6%) were normothermic (median temperature 36.4°C). Using propensity score matching, 567 patient pairs were created. Patients with hypothermia exhibited a higher rate of postoperative transfusion of at least three red cell concentrate units (14.3% vs 9%, p = 0.005), a longer intubation duration (median duration, 6 vs 5 h, p < 0.0001), and a longer intensive care unit stay (median stay, 1.6 vs 1.3 days, p = 0.008). There was no difference in reoperation for bleeding, renal replacement therapy, infections, and mortality between the two groups. Conclusions: Even though associated with a higher blood transfusion requirement and a slightly longer intensive care unit stay, mild postoperative hypothermia was not associated with a higher morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

26. T-Cell Dysfunction in Minimal-Change Nephrotic Syndrome of Childhood

Author

Fodor, Patricia, Saitúa, Maria T., Rodriguez, Eugenio, González, Benito, and Schlesinger, Liana

Abstract

• Cell-mediated immunity was studied in 25 children with minimal-change nephrotic syndrome in different stages of their disease. This was assessed by delayed cutaneous hypersensitivity reactions, number of T lymphocytes, and blastogenic response to phytohemagglutinin and PPD. Patients with active nephrosis could not become sensitized to dinitrochlorobenzene and had decreased response to common recall antigens. T-cell number ranged within normal values in all nephrotic patients. During active disease, lymphocyte transformation was markedly reduced, but improved considerably when cells were cultured in normal plasma. During remission, patients showed normal proliferative response. Reactivity of normal lymphocytes to both stimulants was inhibited by nephrotic plasma. Our results suggest the existence of a serum factor that affects T-cell function.(Am J Dis Child 1982;136:713-717)

Published
1982
Full Text
View/download PDF

29. Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort.

Author

Wendel Garcia PD, Aguirre-Bermeo H, Buehler PK, Alfaro-Farias M, Yuen B, David S, Tschoellitsch T, Wengenmayer T, Korsos A, Fogagnolo A, Kleger GR, Wu MA, Colombo R, Turrini F, Potalivo A, Rezoagli E, Rodríguez-García R, Castro P, Lander-Azcona A, Martín-Delgado MC, Lozano-Gómez H, Ensner R, Michot MP, Gehring N, Schott P, Siegemund M, Merki L, Wiegand J, Jeitziner MM, Laube M, Salomon P, Hillgaertner F, Dullenkopf A, Ksouri H, Cereghetti S, Grazioli S, Bürkle C, Marrel J, Fleisch I, Perez MH, Baltussen Weber A, Ceruti S, Marquardt K, Hübner T, Redecker H, Studhalter M, Stephan M, Selz D, Pietsch U, Ristic A, Heise A, Meyer Zu Bentrup F, Franchitti Laurent M, Fodor P, Gaspert T, Haberthuer C, Colak E, Heuberger DM, Fumeaux T, Montomoli J, Guerci P, Schuepbach RA, Hilty MP, and Roche-Campo F

Subjects
Aged, COVID-19 mortality, Critical Illness mortality, Disease Progression, Female, Hospital Mortality, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies, Registries, Retrospective Studies, Time Factors, Treatment Outcome, COVID-19 therapy, Critical Illness therapy, Respiratory Therapy methods, Respiratory Therapy statistics & numerical data
Abstract

Background: Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates., Methods: Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups., Results: Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016)., Conclusion: In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest that NIV should be avoided whenever possible due to the elevated ICU mortality risk.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results