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3. Non-Fusion Versus Fusion Surgery in Pediatric Idiopathic Scoliosis: What Trade-Offs in Outcomes Are Acceptable for the Patient and Family?

Author

Larson, A. Noelle, Marks, Michelle Claire, Gonzalez Sepulveda, Juan Marcos, Newton, Peter O., Devlin, Vincent J., Peat, Raquel, Tarver, Michelle E., Babalola, Olufemi, Chen, Allen L., Gebben, David, Cahill, Patrick, Shah, Suken, Samdani, Amer, Bachmann, Keith, Lonner, Baron, Buckland, Aaron, Alanay, Ahmet, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Cho, Bob, Yaszay, Burt, Yilgor, Caglar, Hoernschmeyer, Dan, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Marc Mac-Thiong, Jean, Murphy, Josh, Pahys, Joshua, Bachmann, Keith, Neal, Kevin, Blakemore, Laurel, Haber, Lawrence, Lenke, Lawrence, Abel, Mark, Erickson, Mark, Glotzbecker, Michael, Kelly, Michael, Vitale, Michael, Marks, Michelle, Gupta, Munish, Fletcher, Nicholas, Larson, A. Noelle, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter, Sturm, Peter, Betz, Randal, Parent, Stefan, George, Stephen, Hwang, Steven, Shah, Suken, Garg, Sumeet, Errico, Tom, and Upasani, Vidyadhar

Published
2024
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4. Pain Medication Use Two Years After Adolescent Idiopathic Scoliosis Fusion Surgery

Author

Bastrom, Tracey P., Kelly, Michael P., Upasani, Vidyadhar V., Newton, Peter O., Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Asghar, Jahangir, Mac Thiong, Jean Marc, Pahys, Joshua, Harms, Juergen, Bachmann, Keith, Lenke, Lawrence, Abel, Mark, Glotzbecker, Michael, Kelly, Michael P., Vitale, Michael, Marks, Michelle, Gupta, Munish, Fletcher, Nicholas, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter O., Sturm, Peter, Betz, Randal, Lehman, Ron, Parent, Stefan, George, Stephen, Hwang, Steven, Shah, Suken A., Errico, Tom, and Upasani, Vidyadhar V.

Published
2024
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5. Surgical Outcomes of Cerebral Palsy Patients With Scoliosis and Lumbar Hyperlordosis: A Comparative Analysis With 2-year Minimum Follow-up

Author

Lau, Darryl, Samdani, Amer F., Pahys, Joshua M., Miyanji, Firoz, Shah, Suken A., Lonner, Baron S., Sponseller, Paul D., Yaszay, Burt, Hwang, Steven W., Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Asghar, John, Mac Thiong, Jean Marc, Pahys, Joshua, Harms, Juergen, Bachmann, Keith, Lenke, Lawrence, Karol, Lori, Abel, Mark, Erickson, Mark, Glotzbecker, Michael, Kelly, Michael, Vitale, Michael, Marks, Michelle, Gupta, Munish, Fletcher, Nicholas, Larson, Noelle, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter, Sturm, Peter, Betz, Randal, Parent, Stefan, George, Stephen, Hwang, Steven, Shah, Suken, Garg, Sumeet, Errico, Tom, and Upasani, Vidyadhar

Published
2023
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7. Best Practices for the Orthopaedic Care of Children with Spinal Muscular Atrophy: A Consensus Statement from the European Neuromuscular Centre Standard of Care Orthopaedic Working Group

Author

Vitale, Michael, Roye, Benjamin, Bloom, Zachary, Kunes, Jennifer A., Matsumoto, Hiroko, Roye, David, Farrington, David, Flynn, Jack, Halanski, Matthew, Hasler, Carol, Miladi, Lotfi, Quijano-Roy, Susana, Reilly, Christopher, Sponseller, Paul, Yazici, Muharrem, and Snyder, Brian

Published
2022
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8. SRS-22r Self-Image After Surgery for Adolescent Idiopathic Scoliosis at 10-year Follow-up

Author

Stone, Lauren E., Upasani, Vidyadhar V., Pahys, Joshua M., Fletcher, Nicholas D., George, Stephen G., Shah, Suken A., Bastrom, Tracey P., Bartley, Carrie E., Lenke, Lawrence G., Newton, Peter O., Kelly, Michael P., Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Asghar, John, Mac Thiong, Jean Marc, Pahys, Joshua, Harms, Juergen, Bachmann, Keith, Lenke, Lawrence, Karol, Lori, Abel, Mark, Erickson, Mark, Glotzbecker, Michael, Kelly, Michael, Vitale, Michael, Michelle Marks, PT, Gupta, Munish, Fletcher, Nicholas, Larson, Noelle, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter, Sturm, Peter, Betz, Randal, Parent, Stefan, George, Stephen, Hwang, Steven, Shah, Suken, Garg, Sumeet, Errico, Tom, and Upasani, Vidyadhar

Published
2023
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9. Lengthening Behavior of Magnetically Controlled Growing Rods in Early-Onset Scoliosis: A Multicenter Study

Author

Heyer, Jessica H., Anari, Jason B., Baldwin, Keith D., Mitchell, Stuart L., Luhmann, Scott J., Sturm, Peter F., Flynn, John M., Cahill, Patrick J., Abdulfattah Abdullah, Abdullah Saad, Ahn, Edward, Akbarnia, Behrooz, Akoto, Harry, Albanese, Stephen, Anari, Jason, Anderson, John, Anderson, Richard, Andras, Lindsay, Bauer, Jennifer, Bellaire, Laura, Betz, Randy, Birch, Craig, Blakemore, Laurel, Boachie-Adjei, Oheneba, Bonfield, Chris, Bouton, Daniel, Brassard, Felix, Brockmeyer, Douglas, Brooks, Jaysson, Bumpass, David, Cahill, Pat, Chemaly, Olivier, Cheung, Jason, Cheung, Kenneth, Cho, Robert, Christman, Tyler, Beauchamp, Eduardo Colom, Couture, Daniel, Crawford, Haemish, Crawford, Alvin, Dahl, Benny, Demirkiran, Gokhan, Devito, Dennis, Diab, Mohammad, El Sebaie, Hazem, El-Hawary, Ron, Emans, John, Erickson, Mark, Fabregas, Jorge, Farley, Frances, Farrington, David, Fedorak, Graham, Fitzgerald, Ryan, Fletcher, Nicholas, Floccari, Lorena, Flynn, Jack, Gabos, Peter, Gardner, Adrian, Garg, Sumeet, Gerow, Frank, Glotzbecker, Michael, Gomez, Jaime, Gonda, David, Guillaume, Tenner, Gupta, Purnendu, Halvorson, Kyle, Hammerberg, Kim, Hardesty, Christina, Hedequist, Daniel, Heffernan, Michael, Heflin, John, Helenius, Ilkka, Herrera, Jose, Hogue, Grant, Holt, Josh, Howard, Jason, Hresko, Michael Timothy, Hwang, Steven, Ihnow, Stephanie, Ilharreborde, Brice, Illingworth, Kenneth, Jain, Viral, Jea, Andrew, Johnson, Megan, Johnston, Charles, Jones, Morgan, Karlen, Judson, Karlin, Lawrence, Katz, Danielle, Kawakami, Noriaki, Kelly, Brian, Kelly, Derek, Knapp, Raymond, Koljonen, Paul, Kwan, Kenny, Labelle, Hubert, Lark, Robert, Larson, A. Noelle, Lavelle, William, Lenke, Lawrence, Lew, Sean, Li, Gertrude, Louer, Craig, Luhmann, Scott, Mac-Thiong, Jean-Marc, Mackenzie, Stuart, MacKintosh, Erin, Mangano, Francesco, Marks, David, Marquez, Sanchez, Martin, Jonathan, Martus, Jeffrey, Matamalas, Antonia, Mayer, Oscar, McCarthy, Richard, McIntosh, Amy, McQuerry, Jessica, Mehta, Jwalant, Metz, Lionel, Miller, Daniel, Miyanji, Firoz, Mundis, Greg, Murphy, Josh, Murphy, Robert, Myung, Karen, Nelson, Susan, Newton, Peter, Ede, Matthew Newton, Nguyen, Cynthia, Nunez, Susana, Oetgen, Matthew, Oswald, Timothy, Ouellet, Jean, Pahys, Josh, Palomino, Kathryn, Parent, Stefan, Garcia, Alejandro Peiro, Pellise, Ferran, Perra, Joseph, Phillips, Jonathan, Pizones, Javier, Poon, Selina, Price, Nigel, Ramirez-Lluch, Norman, Ramo, Brandon, Redding, Gregory, Ritzman, Todd, Rodriguez, Luis, Rodriguez-Olaverri, Juan Carlos, Roye, David, Roye, Benjamin, Saiman, Lisa, Samdani, Amer, Perez-Grueso, Francisco Sanchez, Sanders, James, Sawyer, Jeffrey, Sayama, Christina, Schmitz, Michael, Schulz, Jacob, Schwend, Richard, Shah, Suken, Shapiro, Jay, Shufflebarger, Harry, Skaggs, David, Smit, Kevin, Smith, John, Snyder, Brian, Sponseller, Paul, Stephen, George, Stone, Joe, Sturm, Peter, Sukkarieh, Hamdi, Swarup, Ishaan, Szczodry, Michal, Thometz, John, Thompson, George, Tomoko, Tanaka, Truong, Walter, Vialle, Raphael, Vitale, Michael, Vorhies, John, Wall, Eric, Wang, Shengru, Warner, Bill, Weinstein, Stuart, Welborn, Michelle, White, Klane, Wrubel, David, Wu, Nan, Yankey, Kwadwo, Yaszay, Burt, Yazici, Muharrem, and Zhang, Terry Jianguo

Published
2022
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10. Anterior Vertebral Body Tethering Compared with Posterior Spinal Fusion for Major Thoracic Curves: A Retrospective Comparison by the Harms Study Group

Author

Newton, Peter O., Parent, Stefan, Miyanji, Firoz, Alanay, Ahmet, Lonner, Baron S., Neal, Kevin M., Hoernschemeyer, Daniel G., Yaszay, Burt, Blakemore, Laurel C., Shah, Suken A., Bastrom, Tracey P., Buckland, Aaron, Alanay, Ahmet, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Cho, Bob, Yaszay, Burt, Yilgor, Caglar, Reilly, Chris, Hoernschmeyer, Dan, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Mac Thiong, Jean Marc, Asghar, John, Murphy, Josh, Pahys, Joshua, Harms, Juergen, Bachmann, Keith, Neal, Kevin, Blakemore, Laurel, Haber, Lawrence, Lenke, Lawrence, Karol, Lori, Abel, Mark, Erickson, Mark, Glotzbecker, Michael, Kelly, Michael, Vitale, Michael, Marks, Michelle, Gupta, Munish, Fletcher, Nicholas, Larson, Noelle, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter, Sturm, Peter, Betz, Randal, Parent, Stefan, George, Stephen, Hwang, Steven, Shah, Suken A., Garg, Sumeet, Errico, Tom, and Upasani, Vidyadhar

Published
2022
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12. Isolation and genomic analysis of "Metallumcola ferriviriculae" MK1, a Gram-positive, Fe(III)-reducing bacterium from the Soudan Underground Mine, an iron-rich Martian analog site.

Author

Hsu, David, Flynn, Jack R., Schuler, Christopher J., Santelli, Cara M., Toner, Brandy M., Bond, Daniel R., and Gralnick, Jeffrey A.

Subjects
*MINES & mineral resources, *GEOBACTER sulfurreducens, *GRAM-positive bacteria, *GRAM-negative bacteria, *GENOMICS, *CYTOCHROME c
Abstract

The Soudan Underground Mine State Park, found in the Vermilion Iron Range in northern Minnesota, provides access to a ~ 2.7 billion-year-old banded iron formation. Exploratory boreholes drilled between 1958 and 1962 on the 27th level (713 m underground) of the mine intersect calcium and iron-rich brines that have recently been subject to metagenomic analysis and microbial enrichments. Using concentrated brine samples pumped from a borehole depth of up to 55 m, a novel Gram-positive bacterium was enriched under anaerobic, acetate-oxidizing, and Fe(III) citrate-reducing conditions. The isolated bacterium, designated strain MK1, is non-motile, rod-shaped, spore-forming, anaerobic, and mesophilic, with a growth range between 24°C and 30°C. The complete circular MK1 genome was found to be 3,720,236 bp and encodes 25 putative multiheme cytochromes, including homologs to inner membrane cytochromes in the Gram-negative bacterium Geobacter sulfurreducens and cytoplasmic membrane and periplasmic cytochromes in the Gram-positive bacterium Thermincola potens. However, MK1 does not encode homologs of the peptidoglycan (CwcA) and cell surface-associated (OcwA) multiheme cytochromes proposed to be required by T. potens to perform extracellular electron transfer. The 16S rRNA gene sequence of MK1 indicates that its closest related isolate is Desulfitibacter alkalitolerans strain sk.kt5 (91% sequence identity), which places MK1 in a novel genus within the Desulfitibacterac eae family and Moorellales order. Within the Moorellales order, only Calderihabitans maritimus strain KKC1 has been reported to reduce Fe(III), and only D. alkalitolerans can also grow in temperatures below 40°C. Thus, MK1 represents a novel species within a novel genus, for which we propose the name "Metallumcola ferriviriculae" strain MK1, and provides a unique opportunity to study a cytochrome-rich, mesophilic, Gram-positive, spore-forming Fe(III)-reducing bacterium. [ABSTRACT FROM AUTHOR]

Published
2024
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13. The Lumbosacral Takeoff Angle Can Be Used to Predict the Postoperative Lumbar Cobb Angle Following Selective Thoracic Fusion in Patients with Adolescent Idiopathic Scoliosis

Author

Bachmann, Keith R., Lu, Edwin, Novicoff, Wendy M., Newton, Peter O., Abel, Mark F., Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, Asghar, Jahangir, Thiong, Jean Marc Mac, Pahys, Joshua, Harms, Juergen, Bachmann, Keith, Lenke, Larry, Glotzbecker, Michael, Kelly, Michael, Vitale, Michael, Marks, Michelle, Gupta, Munish, Fletcher, Nicholas, Cahill, Patrick, Sponseller, Paul, Gabos, Peter, Newton, Peter, Betz, Randal, Lehman, Ron, George, Stephen, Hwang, Steven, Shah, Suken, Errico, Tom, and Upasani, Vidyadhar

Published
2020
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14. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project

Author

Hanlon, Michelle, O'Connor, Laura, and Flynn, Jack

Subjects
FOS: Psychology, Psychology, Social and Behavioral Sciences
Abstract

Recent estimates suggest that up to 34% of frontline workers in healthcare (hereafter referred to as FLWs) at the forefront of the COVID-19 pandemic response are reporting elevated symptoms of psychological distress due to resource constraints, ineffective treatments, and concerns about self-contamination. However, little systematic research has been carried out to assess the mental health needs of FLWs in Europe, or the extent of psychological suffering in FLWs within different European countries of varying outbreak severity. Accordingly, this project will employ a mixed-methods approach over three work packages to develop best-practice guidelines for alleviating psychological distress in FLWs during the different phases of the pandemic. Work package 1 will identify the point and long-term prevalence of psychological distress symptoms in a sample of Irish and Italian FLWs, and the predictors of these symptoms. Work package 2 will perform a qualitative needs assessment on a sample of Irish and Italian FLWs to identify sources of stress and resilience, barriers to psychological care, and optimal strategies for alleviating psychological distress in relation to the COVID-19 pandemic. Work package 3 will synthesise the findings from the preceding work packages to draft best practice guidelines, which will be co-created by a multidisciplinary panel of experts using the Delphi method. The guidelines will provide clinicians with a framework for alleviating psychological distress in FLWs, with particular relevance to the COVID-19 pandemic, but may also have relevance for future pandemics and other public health emergencies.

Published
2022
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15. Low radius of curvature growth-friendly rib-based implants increase the risk of developing clinically significant proximal junctional kyphosis.

Author

Parker, Ellen, Al Anazi, Mohammed, Hurry, Jennifer K., Kawakami, Noriaki, Cheung, Kenneth, Kwan, Kenny, Cheung, Jason, Emans, John, Karlin, Lawrence, Snyder, Brian, Miyanji, Firoz, Gomez, Jaime, Andras, Lindsay, Skaggs, David, Garg, Sumeet, Roye, Benjamin, Vitale, Michael, Saiman, Lisa, Cahill, Patrick, and Flynn, Jack

Published
2023
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17. Definitive fusion for scoliosis in late juvenile cerebral palsy patients is durable at 5 years postoperatively.

Author

Howard, Roland, Sponseller, Paul D., Shah, Suken A., Miyanji, Firoz, Samdani, Amer F., Newton, Peter O., Harms Study Group Investigators, Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Shufflebarger, Harry, Flynn, Jack, and Asghar, John

Published
2022
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19. Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro

Author

Greville, Gordon, Llop, Esther, Huang, Chengnan, Creagh-Flynn, Jack, Pfister, Stephanie, O'Flaherty, Roisin, Madden, Stephen F., Peracaula, Rosa, Rudd, Pauline M., McCann, Amanda, Saldova, Radka, Greville, Gordon, Llop, Esther, Huang, Chengnan, Creagh-Flynn, Jack, Pfister, Stephanie, O'Flaherty, Roisin, Madden, Stephen F., Peracaula, Rosa, Rudd, Pauline M., McCann, Amanda, and Saldova, Radka

Abstract

Background: Glycosylation is one of the most fundamental post-translational modifications. Importantly, glycosylation is altered in many cancers. These alterations have been proven to impact on tumor progression and to promote tumor cell survival. From the literature, it is known that there is a clear link between chemoresistance and hypoxia, hypoxia and epigenetics and more recently glycosylation and epigenetics. Methods and Results: Our objective was to investigate these differential parameters, in an in vitro model of ovarian and breast cancer. Ovarian (A2780, A2780cis, PEO1, PEO4) and triple negative breast cancer (TNBC) (MDA-MB-231 and MDA-MB-436) cells were exposed to differential hypoxic conditions (0.5–2% O2) and compared to normoxia (21% O2). Results demonstrated that in hypoxic conditions some significant changes in glycosylation on the secreted N-glycans from the ovarian and breast cancer cell lines were observed. These included, alterations in oligomannosylated, bisected glycans, glycans with polylactosamine extensions, in branching, galactosylation and sialylation in all cell lines except for PEO1. In general, hypoxia exposed ovarian and TNBC cells also displayed increased epithelial to mesenchymal transition (EMT) and migration, with a greater effect seen in the 0.5% hypoxia exposed samples compared to 1 and 2% hypoxia (p ≤ 0.05). SiRNA transient knock down of GATA2/3 transcription factors resulted in a decrease in the expression of glycosyltransferases ST3GAL4 and MGAT5, which are responsible for sialylation and branching, respectively. Conclusions: These glycan changes are known to be integral to cancer cell survival and metastases, suggesting a possible mechanism of action, linking GATA2 and 3, and invasiveness of both ovarian and TNBC cells in vitro.

Published
2020

20. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project

Author

Flynn, J, O'Connor, L, Hanlon, M, Bellani, G, Contreras, M, Doherty, A, Durand, H, Fallon, E, Gormley, C, Laffey, J, Molloy, G, Sarma, K, Strepparava, M, Russo, S, Walsh, J, Mcguire, B, Flynn, Jack, O'Connor, Laura, Hanlon, Michelle, Bellani, Giacomo, Contreras, Maya, Doherty, Anne, Durand, Hannah, Fallon, Elaine, Gormley, Clare, Laffey, John, Molloy, Gerry, Sarma, Kiran, Strepparava, Maria Grazia, Russo, Selena, Walsh, Jane, McGuire, Brian E., Flynn, J, O'Connor, L, Hanlon, M, Bellani, G, Contreras, M, Doherty, A, Durand, H, Fallon, E, Gormley, C, Laffey, J, Molloy, G, Sarma, K, Strepparava, M, Russo, S, Walsh, J, Mcguire, B, Flynn, Jack, O'Connor, Laura, Hanlon, Michelle, Bellani, Giacomo, Contreras, Maya, Doherty, Anne, Durand, Hannah, Fallon, Elaine, Gormley, Clare, Laffey, John, Molloy, Gerry, Sarma, Kiran, Strepparava, Maria Grazia, Russo, Selena, Walsh, Jane, and McGuire, Brian E.

Abstract

Recent estimates suggest that up to 34% of frontline workers in healthcare (FLWs) at the forefront of the COVID-19 pandemic response are reporting elevated symptoms of psychological distress due to resource constraints, ineffective treatments, and concerns about self-contamination. However, little systematic research has been carried out to assess the mental health needs of FLWs in Europe, or the extent of psychological suffering in FLWs within different European countries of varying outbreak severity. Accordingly, this project will employ a mixed-methods approach over three work packages to develop best-practice guidelines for alleviating psychological distress in FLWs during the different phases of the pandemic. Work package 1 will identify the point and long-term prevalence of psychological distress symptoms in a sample of Irish and Italian FLWs, and the predictors of these symptoms. Work package 2 will perform a qualitative needs assessment on a sample of Irish and Italian FLWs to identify sources of stress and resilience, barriers to psychological care, and optimal strategies for alleviating psychological distress in relation to the COVID-19 pandemic. Work package 3 will synthesise the findings from the preceding work packages to draft best practice guidelines, which will be co-created by a multidisciplinary panel of experts using the Delphi method. The guidelines will provide clinicians with a framework for alleviating psychological distress in FLWs, with particular relevance to the COVID-19 pandemic, but may also have relevance for future pandemics and other public health emergencies.

Published
2020

21. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project

Author

Flynn, Jack, primary, O'Connor, Laura, additional, Hanlon, Michelle, additional, Bellani, Giacomo, additional, Contreras, Maya, additional, Doherty, Anne, additional, Durand, Hannah, additional, Fallon, Elaine, additional, Gormley, Clare, additional, Laffey, John, additional, Molloy, Gerry, additional, Sarma, Kiran, additional, Strepparava, Maria Grazia, additional, Russo, Selena, additional, Walsh, Jane, additional, and McGuire, Brian E., additional

Published
2021
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22. The Role of Attachment Style, Adverse Childhood Experiences and Dissociation in Migraine.

Author

Mays, Iain, Flynn, Jack, McGuire, Brian, and Egan, Jonathan

Subjects
*ADVERSE childhood experiences, *PSYCHOLOGICAL abuse, *CONFIDENCE intervals, *MIGRAINE, *DISSOCIATIVE disorders, *CROSS-sectional method, *ATTACHMENT behavior, *RISK assessment, *DISABILITIES, *DESCRIPTIVE statistics, *MENTAL depression, *FACTOR analysis, *QUESTIONNAIRES, *LOGISTIC regression analysis, *ODDS ratio, MIGRAINE risk factors
Abstract

Migraine and chronic migraine are caused by a combination of modifiable and non-modifiable genetic, social, behavioral and environmental risk factors. Further research of possible modifiable risk factors for this headache disorder is merited, given its role as one of the leading causes of years lived with disability per year. The first aim of this online cross-sectional study was to investigate the psychosocial risk factors that predicted chronic migraine and severe migraine-related disability in 507 Irish and UK participants, focusing specifically on childhood maltreatment, attachment and tendency to dissociate, or experience depressed mood and/or anxiety. Additionally, this study aimed to examine variables that mediated the relationships between these psychosocial risk factors and migraine chronicity or severe migraine-related disability. Adjusted binary logistic regression revealed that shutdown dissociation (Odds Ratio [OR] 4.57, 95% Confidence Interval [CI] 2.66–7.85) and severe physical abuse (OR 4.30, 95% CI 1.44–12.83 had significant odds of predicting migraine chronicity, while depression (OR 3.28, 95% CI 1.86–5.77) significantly predicted severe migraine-related disability. Mediation analyses indicated that shutdown dissociation mediated the relationship between seven predictor variables and both chronicity and severe disability including possible predisposing factors emotional abuse, physical neglect, avoidant attachment and anxious attachment. These findings suggest that early life stressors (such as childhood trauma and avoidant attachment style), shutdown dissociation and depression may impact on migraine trajectory. To investigate whether these psychosocial factors are risk factors for migraine chronicity or disability, prospective research should be conducted in this area to account for fluctuations in migraine chronicity over time. [ABSTRACT FROM AUTHOR]

Published
2022
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24. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project

Author

Flynn, Jack, primary, O'Connor, Laura, additional, Hanlon, Michelle, additional, Bellani, Giacomo, additional, Contreras, Maya, additional, Doherty, Anne, additional, Durand, Hannah, additional, Fallon, Elaine, additional, Gormley, Clare, additional, Laffey, John, additional, Molloy, Gerry, additional, Sarma, Kiran, additional, Strepparava, Maria Grazia, additional, Russo, Selena, additional, Walsh, Jane, additional, and McGuire, Brian E., additional

Published
2020
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29. Lycopene in human health

Author

Caseiro, Mélanie, primary, Ascenso, Andreia, additional, Costa, Ana, additional, Creagh-Flynn, Jack, additional, Johnson, Melissa, additional, and Simões, Sandra, additional

Published
2020
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31. 44th International Industrial Engineering Conference highlights

Author

Schilling, Cliff, Baer, John, Hill, Ian D., Swann, Don, and Flynn, Jack

Subjects
Industrial engineering, Conferences and Meetings, Industrial engineering -- Conferences, meetings and seminars
Abstract

The 44th International Industrial Engineering Conference will be held this year in Los Angeles, Calif., May 24-26. The conference will offer 10 information "Tracks," each including presentations (over 100) by […]

Published
1993

34. Including the stable sagittal vertebra in the fusion for adolescent idiopathic scoliosis reduces the risk of distal junctional kyphosis in Lenke 1–3 B and C curves.

Author

Marciano, Gerard, Ball, Jacob, Matsumoto, Hiroko, Roye, Benjamin, Lenke, Lawrence, Newton, Peter, Vitale, Michael, Harms Study Group, Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Yaszay, Burt, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, and Flynn, Jack

Published
2021
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35. Commissioning TES systems

Author

Guven, Halil and Flynn, Jack

Subjects
Heating, ventilation, and air conditioning industry -- Laws, regulations and rules -- Standards -- Conferences, meetings and seminars -- Environmental aspects, Buildings -- Environmental aspects -- Standards -- Usage -- Conferences, meetings and seminars -- Laws, regulations and rules, Heat engineering -- Conferences, meetings and seminars -- Environmental aspects -- Laws, regulations and rules, Heat storage devices -- Usage -- Conferences, meetings and seminars -- Standards -- Laws, regulations and rules -- Environmental aspects, Heat storage -- Standards -- Conferences, meetings and seminars -- Laws, regulations and rules -- Environmental aspects, Business, Construction and materials industries, Environmental services industry, Government regulation, Standards, Usage, Conferences, meetings and seminars, Environmental aspects, Laws, regulations and rules
Abstract

If properly designed, installed, operated, and maintained, thermal energy storage (TES) systems shift heavy daytime cooling loads to off-peak nighttime periods. This load shift allows TES system owners to cover [...]

Published
1992

36. Associations between three-dimensional measurements of the spinal deformity and preoperative SRS-22 scores in patients undergoing surgery for major thoracic adolescent idiopathic scoliosis.

Author

Ohashi, Masayuki, Bastrom, Tracey P., Bartley, Carrie E., Yaszay, Burt, Upasani, Vidyadhar V., Newton, Peter O., the Harms Study Group, Buckland, Aaron, Samdani, Amer, Jain, Amit, Lonner, Baron, Roye, Benjamin, Reilly, Chris, Hedequist, Daniel, Sucato, Daniel, Clements, David, Miyanji, Firoz, Shufflebarger, Harry, Flynn, Jack, and Asghar, Jahangir

Published
2020
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40. Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopedic and nutritional care

Author

Mercuri, Eugenio, primary, Finkel, Richard S., additional, Muntoni, Francesco, additional, Wirth, Brunhilde, additional, Montes, Jacqueline, additional, Main, Marion, additional, Mazzone, Elena S., additional, Vitale, Michael, additional, Snyder, Brian, additional, Quijano-Roy, Susana, additional, Bertini, Enrico, additional, Davis, Rebecca Hurst, additional, Meyer, Oscar H., additional, Simonds, Anita K., additional, Schroth, Mary K., additional, Graham, Robert J., additional, Kirschner, Janbernd, additional, Iannaccone, Susan T., additional, Crawford, Thomas O., additional, Woods, Simon, additional, Qian, Ying, additional, Sejersen, Thomas, additional, Tiziano, Francesco Danilo, additional, Tizzano, Eduardo, additional, Topaloglu, Haluk, additional, Swoboda, Kathy, additional, Laing, Nigel, additional, Kayoko, Saito, additional, Prior, Thomas, additional, Chung, Wendy K., additional, Wu, Shou-Mei, additional, Mazzone, Elena, additional, Coleman, Caron, additional, Gee, Richard, additional, Glanzman, Allan, additional, Kroksmark, Anna-Karin, additional, Krosschell, Kristin, additional, Nelson, Leslie, additional, Rose, Kristy, additional, Stępień, Agnieszka, additional, Vuillerot, Carole, additional, Dubousset, Jean, additional, Farrington, David, additional, Flynn, Jack, additional, Halanski, Matthew, additional, Hasler, Carol, additional, Miladi, Lotfi, additional, Reilly, Christopher, additional, Roye, Benjamin, additional, Sponseller, Paul, additional, Yazici, Muharrem, additional, Hurst, Rebecca, additional, Tarrant, Stacey, additional, Barja, Salesa, additional, Bertoli, Simona, additional, Crawford, Thomas, additional, Foust, Kevin, additional, Kyle, Barbara, additional, Rodan, Lance, additional, Roper, Helen, additional, Seffrood, Erin, additional, Swoboda, Kathryn, additional, and Szlagatys-Sidorkiewicz, Agnieszka, additional

Published
2018
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41. Injectable hyperbranched poly(β-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes

Author

Xu, Qian, primary, Guo, Linru, additional, A, Sigen, additional, Gao, Yongsheng, additional, Zhou, Dezhong, additional, Greiser, Udo, additional, Creagh-Flynn, Jack, additional, Zhang, Hong, additional, Dong, Yixiao, additional, Cutlar, Lara, additional, Wang, Fagang, additional, Liu, Wenguang, additional, Wang, Wei, additional, and Wang, Wenxin, additional

Published
2018
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43. Get tough with your vendors about freight

Author

Flynn, Jack

Subjects
Materials handling -- Methods, Freight -- Management, Freight forwarders -- Management, Automobile industry, Business, Transportation industry
Abstract

Several techniques are presented that can assist shippers in telling their carriers, or vendors, how to properly ship freight. Shippers must learn to demand quality service from carriers. By carefully studying carrier activity, shippers can be able to reduce unnecessary inbound freight costs through a number of ways., Vendors will take advantage of you if they can, but if you know how to fight back, you can protect yourself from being hit too hard. You have the right [...]

Published
1993

44. A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing.

Author

Xu, Qian, A, Sigen, Gao, Yongsheng, Guo, Linru, Creagh-Flynn, Jack, Zhou, Dezhong, Greiser, Udo, Dong, Yixiao, Wang, Fagang, Tai, Hongyun, Liu, Wenguang, Wang, Wei, and Wang, Wenxin

Subjects
HYDROGELS, BIOCOMPATIBILITY, ETHYLENE glycol, STEM cells, IMMUNOSTAINING
Abstract

The injectable hydrogel with desirable biocompatibility and tunable properties can improve the efficacy of stem cell-based therapy. However, the development of injectable hydrogel remains a great challenge due to the restriction of crosslinking efficiency, mechanical properties, and potential toxicity. Here, we report that a new injectable hydrogel system was fabricated from hyperbranched multi-acrylated poly(ethylene glycol) macromers (HP-PEGs) and thiolated hyaluronic acid (HA-SH) and used as a stem cell delivery and retention platform. The new HP-PEGs were synthesized via in situ reversible addition fragmentation chain transfer (RAFT) polymerization using an FDA approved anti-alcoholic drug-Disulfiram (DS) as the RAFT agent precursor. HP-PEGs can form injectable hydrogels with HA-SH rapidly via thiol-ene click reaction under physiological conditions. The hydrogels exhibited stable mechanical properties, non-swelling and anti-fouling properties. Hydrogels encapsulating adipose-derived stem cells (ADSCs) have demonstrated promising regenerative capabilities such as the maintenance of ADSCs’ stemness and secretion abilities. The ADSCs embedded hydrogels were tested on the treatment of diabetic wound in a diabetic murine animal model, showing enhanced wound healing. Statement of Significance Diabetic wounds, which are a severe type of diabetes, have become one of the most serious clinical problems. There is a great promise in the delivery of adipose stem cells into wound sites using injectable hydrogels that can improve diabetic wound healing. Due to the biocompatibility of poly(ethylene glycol) diacrylate (PEGDA), we developed an in situ RAFT polymerization approach using anti-alcoholic drug-Disulfiram (DS) as a RAFT agent precursor to achieve hyperbranched PEGDA (HP-PEG). HP-PEG can form an injectable hydrogel by crosslinking with thiolated hyaluronic acid (HA-SH). ADSCs can maintain their regenerative ability and be delivered into the wound sites. Hence, diabetic wound healing process was remarkably promoted, including inhibition of inflammation, enhanced angiogenesis and re-epithelialization. Taken together, the ADSCs-seeded injectable hydrogel may be a promising candidate for diabetic wound treatment. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Paper #19: The Etiology of Thoracic Insufficiency Syndrome in Neuromuscular Scoliosis Based on Quantitative Dynamic Lung MRI (QdMRI)

Author

Campbell, Robert M., primary, Udupa, Jay, additional, Flynn, Jack, additional, Mayer, Hank, additional, Nance, Michael, additional, Panitch, Howard, additional, Wang, Wei-Hsun, additional, Tong, Yubing, additional, Wu, Ivy, additional, Baldwin, Kieth, additional, McDonough, Joseph, additional, and Mong, Andrew, additional

Published
2014
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48. Leadership in global markets

Author

Cavarkapa, Branko, Flynn, Jack, Cavarkapa, Branko, and Flynn, Jack

Abstract

The key to successfully competing in the global marketplace may be staffing key expatriate positions with accomplished/skilled leaders. Past research has focused on preparing managers to successfully expatriate to foreign assignment and repatriate back to the United States. The high failure rate and general lack of effectiveness of many expatriate managers may be attributed to a cultural mismatch between the assignment and the leadership style of the expatriate. This paper explains the complex issues associated with multicultural leadership. The purpose of this paper is to identify key issues associated with leadership and the adaptation of these concepts into an international context.

Published
2008

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