48 results on '"Flurin, Laure"'
Search Results
2. Hypochlorous acid produced at the counter electrode inhibits catalase and increases bactericidal activity of a hydrogen peroxide generating electrochemical bandage
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Anoy, Md Monzurul Islam, Gelston, Suzanne, Mohamed, Abdelrhman, Flurin, Laure, Raval, Yash S., Greenwood-Quaintance, Kerryl, Patel, Robin, Lewandowski, Zbigniew, and Beyenal, Haluk
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- 2022
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3. Characteristics and Predictors of Patients with Sepsis who are Candidates for Minimally Invasive Approach Outside of Intensive Care Unit
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Wahab, Abdul, Smith, Ryan J., Lal, Amos, Flurin, Laure, Malinchoc, Michael, Dong, Yue, and Gajic, Ognjen
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- 2023
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4. Targeted next generation sequencing for elbow periprosthetic joint infection diagnosis
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Flurin, Laure, Wolf, Matthew J., Greenwood-Quaintance, Kerryl E., Sanchez-Sotelo, Joaquin, and Patel, Robin
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- 2021
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5. Sonication improves microbiologic diagnosis of periprosthetic elbow infection
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Flurin, Laure, Greenwood-Quaintance, Kerryl E., Esper, Ronda N., Sanchez-Sotelo, Joaquin, and Patel, Robin
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- 2021
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6. Does the Surgical Approach Influence the Canal Fill of the Proximal Femur for Hip Arthroplasty?
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Mattesi, Lucas, Cheyrou-Lagrèze, Adrien, Odri, Guillaume-Anthony, Duhil, Antoine, Flurin, Laure, and Severyns, Mathieu
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- 2021
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7. Microbiology of polymicrobial prosthetic joint infection
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Flurin, Laure, Greenwood-Quaintance, Kerryl E., and Patel, Robin
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- 2019
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8. Comparison of Blood-Based Shotgun and Targeted Metagenomic Sequencing for Microbiological Diagnosis of Infective Endocarditis
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Flurin, Laure, primary, Fisher, Cody R, additional, Wolf, Matthew J, additional, Pritt, Bobbi S, additional, DeSimone, Daniel C, additional, and Patel, Robin, additional
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- 2023
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9. Gaining consensus on expert rule statements for acute respiratory failure digital twin patient model in intensive care unit using a Delphi method
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Montgomery, Amy J., primary, Litell, John, additional, Dang, Johnny, additional, Flurin, Laure, additional, Gajic, Ognjen, additional, Lal, Amos, additional, and Research, and healthcare delivery investigator group, On behalf of Digital Twin Platform for education,, additional
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- 2023
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10. Prognostic and therapeutic interest of a new classification in inferior hip dislocation: a systematic review of the literature.
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Severyns, Mathieu, Flurin, Laure, and Odri, Guillaume A
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THERAPEUTICS , *ONLINE information services , *MEDICAL databases , *STRATEGIC planning , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *HIP joint dislocation , *MEDLINE , *DISEASE complications - Abstract
Introduction: Reported cases of inferior dislocation in the literature are found under several names (inferior, anteroinferior, obturator, or erecta), which may be source of confusion. The purpose of this comprehensive review of the literature is to collect as many cases of inferior dislocation as possible to determine better therapeutic strategies, outcome after reduction, complications, and prognostic factors. Methods: In April 2020, a literature search was performed in Pubmed, Medline, Scopus, Cochrane, and Embase databases. The MeSH keywords were "OBTURATOR DISLOCATION HIP" or "ANTERIOR DISLOCATION HIP" or "INFERIOR DISLOCATION HIP." Authors independently selected articles that met the selection criteria, with no time limit. Results: Out of the 97 articles selected, there were 119 cases of primary inferior hip dislocations. This review of the literature has allowed us to differentiate 3 radiographic subtypes of inferior dislocations, which correspond to 3 different anatomical positions of the femoral head: "obturator" dislocation, "proximal anterior-inferior" dislocation, and "distal anterior-inferior" dislocation. Our subtype classification yielded 39 obturator subtype inferior dislocations (32.8%), 66 proximal anteroinferior subtypes (55.4%), and 14 distal anteroinferior (11.8%). The obturator subtype is at risk of reduction failure and femoral neck fracture during the reduction manoeuver. Conclusions: Our study identified 3 subtypes with different prognosis, with obturator and distal anteroinferior dislocations having a poorer prognosis because of their pre- and post-reduction complications. We were unable to determine the correct manoeuver to reduce inferior dislocations without taking the risk of femoral neck fracture, but each of these subtypes may require a different manoeuver. [ABSTRACT FROM AUTHOR]
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- 2023
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11. Clinical Use of a 16S Ribosomal RNA Gene-Based Sanger and/or Next Generation Sequencing Assay to Test Preoperative Synovial Fluid for Periprosthetic Joint Infection Diagnosis
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Flurin, Laure, primary, Hemenway, Joseph J., additional, Fisher, Cody R., additional, Vaillant, James J., additional, Azad, Marisa, additional, Wolf, Matthew J., additional, Greenwood-Quaintance, Kerryl E., additional, Abdel, Matthew P., additional, and Patel, Robin, additional
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- 2022
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12. 291: DEVELOPING DELPHI EXPERT CONSENSUS RULES FOR A DIGITAL TWIN MODEL OF THE NEURO CRITICAL CARE UNIT
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Dang, Johnny, primary, Lal, Amos, additional, Rabinstein, Alejandro, additional, Gajic, Ognjen, additional, Flurin, Laure, additional, Montgomery, Amy, additional, and Litell, John, additional
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- 2022
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13. 59: PREDICTION MODEL TO IDENTIFY SEPSIS PATIENTS FOR MINIMALLY INVASIVE MANAGEMENT OUTSIDE THE ICU
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Wahab, Abdul, primary, Smith, Ryan, additional, Lal, Amos, additional, Flurin, Laure, additional, Malinchoc, Michael, additional, Dong, Yue, additional, and Gajic, Ognjen, additional
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- 2022
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14. Efficacy and toxicity of hydrogen peroxide producing electrochemical bandages in a porcine explant biofilm model
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Tibbits, Gretchen, primary, Mohamed, Abdelrhman, additional, Gelston, Suzanne, additional, Flurin, Laure, additional, Raval, Yash S., additional, Greenwood-Quaintance, Kerryl, additional, Patel, Robin, additional, and Beyenal, Haluk, additional
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- 2022
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15. Antibiofilm Activity of a Tunable Hypochlorous Acid‐Generating Electrochemical Bandage Controlled by a Wearable Potentiostat
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Mohamed, Abdelrhman, primary, Raval, Yash S., additional, Gelston, Suzanne, additional, Tibbits, Gretchen, additional, Ay, Suat U., additional, Flurin, Laure, additional, Greenwood-Quaintance, Kerryl E., additional, Patel, Robin, additional, and Beyenal, Haluk, additional
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- 2022
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16. Prognostic and therapeutic interest of a new classification in inferior hip dislocation: a systematic review of the literature
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Severyns, Mathieu, primary, Flurin, Laure, additional, and Odri, Guillaume A, additional
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- 2022
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17. Activity of a hypochlorous acid‐producing electrochemical bandage as assessed with a porcine explant biofilm model
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Tibbits, Gretchen, primary, Mohamed, Abdelrhman, additional, Gelston, Suzanne, additional, Flurin, Laure, additional, Raval, Yash S., additional, Greenwood‐Quaintance, Kerryl E., additional, Patel, Robin, additional, and Beyenal, Haluk, additional
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- 2022
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18. Pathogen Detection in Infective Endocarditis Using Targeted Metagenomics on Whole Blood and Plasma: a Prospective Pilot Study
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Flurin, Laure, primary, Wolf, Matthew J., additional, Fisher, Cody R., additional, Cano Cevallos, Edison J., additional, Vaillant, James J., additional, Pritt, Bobbi S., additional, DeSimone, Daniel C., additional, and Patel, Robin, additional
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- 2022
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19. Surgical Site Infections after Spinal Surgery in a Tropical Area: A Prospective Monocentric Observational Study
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Severyns, Mathieu, primary, Hostalrich, François-Xavier, additional, Flurin, Laure, additional, Vendeuvre, Tanguy, additional, Germaneau, Arnaud, additional, Turmel, Jean-Marie, additional, Cabié, André, additional, and Benchikh El-Fegoun, Abdelkrim, additional
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- 2022
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20. Targeted Versus Shotgun Metagenomic Sequencing-based Detection of Microorganisms in Sonicate Fluid for Periprosthetic Joint Infection Diagnosis
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Hong, Hyo-Lim, primary, Flurin, Laure, additional, Thoendel, Matthew J, additional, Wolf, Matthew J, additional, Abdel, Matthew P, additional, Greenwood-Quaintance, Kerryl E, additional, and Patel, Robin, additional
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- 2022
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21. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis
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Hajage, David, primary, Combes, Alain, additional, Guervilly, Christophe, additional, Lebreton, Guillaume, additional, Mercat, Alain, additional, Pavot, Arthur, additional, Nseir, Saad, additional, Mekontso-Dessap, Armand, additional, Mongardon, Nicolas, additional, Mira, Jean Paul, additional, Ricard, Jean-Damien, additional, Beurton, Alexandra, additional, Tachon, Guillaume, additional, Kontar, Loay, additional, Le Terrier, Christophe, additional, Richard, Jean Christophe, additional, Mégarbane, Bruno, additional, Keogh, Ruth H., additional, Belot, Aurélien, additional, Maringe, Camille, additional, Leyrat, Clémence, additional, Schmidt, Matthieu, additional, Asfar, Pierre, additional, Beloncle, François, additional, Demiselle, Julien, additional, Pham, Tài, additional, Monnet, Xavier, additional, Richard, Christian, additional, Demoule, Alexandre, additional, Dres, Martin, additional, Mayaux, Julien, additional, Daubin, Cédric, additional, Descamps, Richard, additional, Joret, Aurélie, additional, Du Cheyron, Damien, additional, Pene, Frédéric, additional, Chiche, Jean-Daniel, additional, Jozwiak, Mathieu, additional, Jaubert, Paul, additional, Voiriot, Guillaume, additional, Fartoukh, Muriel, additional, Teulier, Marion, additional, Blayau, Clarisse, additional, L'Her, Erwen, additional, Aubron, Cécile, additional, Bodenes, Laetitia, additional, Ferriere, Nicolas, additional, Auchabie, Johann, additional, Le Meur, Anthony, additional, Pignal, Sylvain, additional, Mazzoni, Thierry, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Roudau, Jean-Baptiste, additional, Labruyère, Marie, additional, Preau, Sébastien, additional, Poissy, Julien, additional, Mathieu, Daniel, additional, Benhamida, Sarah, additional, Paulet, Rémi, additional, Roucaud, Nicolas, additional, Thyrault, Martial, additional, Daviet, Florence, additional, Hraiech, Sami, additional, Parzy, Gabriel, additional, Sylvestre, Aude, additional, Jochmans, Sébastien, additional, Bouilland, Anne-Laure, additional, Monchi, Mehran, additional, Danguy des Déserts, Marc, additional, Mathais, Quentin, additional, Rager, Gwendoline, additional, Pasquier, Pierre, additional, Reignier, Jean, additional, Seguin, Amélie, additional, Garret, Charlotte, additional, Canet, Emmanuel, additional, Dellamonica, Jean, additional, Saccheri, Clément, additional, Lombardi, Romain, additional, Kouchit, Yanis, additional, Jacquier, Sophie, additional, Mathonnet, Armelle, additional, Nay, Mai-Ahn, additional, Runge, Isabelle, additional, Martino, Frédéric, additional, Flurin, Laure, additional, Rolle, Amélie, additional, Carles, Michel, additional, Coudroy, Rémi, additional, W. Thille, Arnaud, additional, Frat, Jean-Pierre, additional, Rodriguez, Maeva, additional, Beuret, Pascal, additional, Tientcheu, Audrey, additional, Vincent, Arthur, additional, Michelin, Florian, additional, Tamion, Fabienne, additional, Carpentier, Dorothée, additional, Boyer, Déborah, additional, Beduneau, Gaetan, additional, Gissot, Valérie, additional, Ehrmann, Stéphan, additional, Salmon Gandonniere, Charlotte, additional, Elaroussi, Djlali, additional, Delbove, Agathe, additional, Fedun, Yannick, additional, Huntzinger, Julien, additional, Lebas, Eddy, additional, Kisoka, Grâce, additional, Grégoire, Céline, additional, Marchetta, Stella, additional, Lambermont, Bernard, additional, Argaud, Laurent, additional, Baudry, Thomas, additional, Bertrand, Pierre-Jean, additional, Dargent, Auguste, additional, Guitton, Christophe, additional, Chudeau, Nicolas, additional, Landais, Mickaël, additional, Darreau, Cédric, additional, Ferre, Alexis, additional, Gros, Antoine, additional, Lacave, Guillaume, additional, Bruneel, Fabrice, additional, Neuville, Mathilde, additional, Devaquet, Jérôme, additional, Gallot, Richard, additional, Chelha, Riad, additional, Galbois, Arnaud, additional, Jallot, Anne, additional, Chalumeau Lemoine, Ludivine, additional, Kuteifan, Khaldoun, additional, Pointurier, Valentin, additional, Jandeaux, Louise-Marie, additional, Mootien, Joy, additional, Damoisel, Charles, additional, Sztrymf, Benjamin, additional, Chommeloux, Juliette, additional, Edouard Luyt, Charles, additional, Schortgen, Frédérique, additional, Rusel, Leon, additional, Jung, Camille, additional, Gobert, Florent, additional, Vimpere, Damien, additional, Lamhaut, Lionel, additional, Sauneuf, Bertrand, additional, Charrrier, Liliane, additional, Calus, Julien, additional, Desmeules, Isabelle, additional, Painvin, Benoît, additional, Tadie, Jean-Marc, additional, Castelain, Vincent, additional, Michard, Baptiste, additional, Herbrecht, Jean-Etienne, additional, Baldacini, Mathieu, additional, Weiss, Nicolas, additional, Demeret, Sophie, additional, Marois, Clémence, additional, Rohaut, Benjamin, additional, Moury, Pierre-Henri, additional, Savida, Anne-Charlotte, additional, Couadau, Emmanuel, additional, Série, Mathieu, additional, Alexandru, Nica, additional, Bruel, Cédric, additional, Fontaine, Candice, additional, Garrigou, Sonia, additional, Courtiade Mahler, Juliette, additional, Leclerc, Maxime, additional, Ramakers, Michel, additional, Garçon, Pierre, additional, Massou, Nicole, additional, Van Vong, Ly, additional, Sen, Juliane, additional, Lucas, Nolwenn, additional, Chemouni, Franck, additional, Stoclin, Annabelle, additional, Avenel, Alexandre, additional, Faure, Henri, additional, Gentilhomme, Angélie, additional, Ricome, Sylvie, additional, Abraham, Paul, additional, Monard, Céline, additional, Textoris, Julien, additional, Rimmele, Thomas, additional, Montini, Florent, additional, Lejour, Gabriel, additional, Lazard, Thierry, additional, Etienney, Isabelle, additional, Kerroumi, Younes, additional, Dupuis, Claire, additional, Bereiziat, Marine, additional, Coupez, Elisabeth, additional, Thouy, François, additional, Hoffmann, Clément, additional, Donat, Nicolas, additional, Chrisment, Anne, additional, Blot, Rose-Marie, additional, Kimmoun, Antoine, additional, Jacquot, Audrey, additional, Mattei, Matthieu, additional, Levy, Bruno, additional, Ravan, Ramin, additional, Dopeux, Loïc, additional, Liteaudon, Jean-Mathias, additional, Roux, Delphine, additional, Rey, Brice, additional, Anghel, Radu, additional, Schenesse, Deborah, additional, Gevrey, Vincent, additional, Castanera, Jermy, additional, Petua, Philippe, additional, Madeux, Benjamin, additional, Hartman, Otto, additional, Piagnerelli, Michael, additional, Joosten, Anne, additional, Noel, Cinderella, additional, Biston, Patrick, additional, Noel, Thibaut, additional, LE Bouar, Gurvan, additional, Boukhanza, Messabi, additional, Demarest, Elsa, additional, Bajolet, Marie-France, additional, Charrier, Nathanaël, additional, Quenet, Audrey, additional, Zylberfajn, Cécile, additional, Dufour, Nicolas, additional, Mégarbane, Buno, additional, Voicu, Sébastian, additional, Deye, Nicolas, additional, Malissin, Isabelle, additional, Legay, François, additional, Debarre, Matthieu, additional, Barbarot, Nicolas, additional, Fillatre, Pierre, additional, Delord, Bertrand, additional, Laterrade, Thomas, additional, Saghi, Tahar, additional, Pujol, Wilfried, additional, Julien Cungi, Pierre, additional, Esnault, Pierre, additional, Cardinale, Mickael, additional, Hong Tuan Ha, Vivien, additional, Fleury, Grégory, additional, Brou, Marie-Ange, additional, Zafimahazo, Daniel, additional, Tran-Van, David, additional, Avargues, Patrick, additional, Carenco, Lisa, additional, Robin, Nicolas, additional, Ouali, Alexandre, additional, Houdou, Lucie, additional, Suh, Noémie, additional, Primmaz, Steve, additional, Pugin, Jérome, additional, Weiss, Emmanuel, additional, Gauss, Tobias, additional, Moyer, Jean-Denis, additional, Paugam Burtz, Catherine, additional, La Combe, Béatrice, additional, Smonig, Rolland, additional, Violleau, Jade, additional, Cailliez, Pauline, additional, Chelly, Jonathan, additional, Marchalot, Antoine, additional, Saladin, Cécile, additional, Bigot, Christelle, additional, Fayolle, Pierre-Marie, additional, Fatséas, Jules, additional, Ibrahim, Amr, additional, Resiere, Dabor, additional, Hage, Rabih, additional, Cholet, Clémentine, additional, Cantier, Marie, additional, Trouiler, Pierre, additional, Montravers, Philippe, additional, Lortat-Jacob, Brice, additional, Tanaka, Sebastien, additional, Tran Dinh, Alexy, additional, Duranteau, Jacques, additional, Harrois, Anatole, additional, Dubreuil, Guillaume, additional, Werner, Marie, additional, Godier, Anne, additional, Hamada, Sophie, additional, Zlotnik, Diane, additional, Nougue, Hélène, additional, Carteaux, Guillaume, additional, Razazi, Keyvan, additional, De Prost, Nicolas, additional, Lamraoui, Meriam, additional, Alessandri, Claire, additional, de Roux, Quentin, additional, de Roquetaillade, Charles, additional, G. Chousterman, Benjamin, additional, Mebazaa, Alexandre, additional, Gayat, Etienne, additional, Garnier, Marc, additional, Pardo, Emmanuel, additional, Satre-Buisson, Lea, additional, Gutton, Christophe, additional, Yvin, Elise, additional, Marcault, Clémence, additional, Azoulay, Elie, additional, Darmon, Michael, additional, Ait Oufella, Hafid, additional, Hariri, Geoffroy, additional, Urbina, Tomas, additional, Mazerand, Sandie, additional, Heming, Nicholas, additional, Santi, Francesca, additional, Moine, Pierre, additional, Annane, Djillali, additional, Bouglé, Adrien, additional, Omar, Edris, additional, Lancelot, Aymeric, additional, Begot, Emmanuelle, additional, Plantefeve, Gaétan, additional, Contou, Damien, additional, Mentec, Hervé, additional, Pajot, Olivier, additional, Faguer, Stanislas, additional, Cointault, Olivier, additional, Lavayssiere, Laurence, additional, Nogier, Marie-Béatrice, additional, Jamme, Matthieu, additional, Pichereau, Claire, additional, Hayon, Jan, additional, Outin, Hervé, additional, Dépret, François, additional, Coutrot, Maxime, additional, Chaussard, Maité, additional, Guillemet, Lucie, additional, Goffin, Pierre, additional, Thouny, Romain, additional, Guntz, Julien, additional, Jadot, Laurent, additional, Persichini, Romain, additional, Jean-Michel, Vanessa, additional, Georges, Hugues, additional, Caulier, Thomas, additional, Pradel, Gaël, additional, Hausermann, Marie-Hélène, additional, Nguyen-Valat, Thi My Hue, additional, Boudinaud, Michel, additional, Vivier, Emmanuel, additional, Rosseli, Sylvène, additional, Bourdin, Gaël, additional, Pommier, Christian, additional, Vinclair, Marc, additional, Poignant, Simon, additional, Mons, Sandrine, additional, Bougouin, Wulfran, additional, Bruna, Franklin, additional, Maestraggi, Quentin, additional, Roth, Christian, additional, Bitker, Laurent, additional, Dhelft, François, additional, Bonnet-Chateau, Justine, additional, Filippelli, Mathilde, additional, Morichau-Beauchant, Tristan, additional, Thierry, Stéphane, additional, Le Roy, Charlotte, additional, Saint Jouan, Mélanie, additional, Goncalves, Bruno, additional, Mazeraud, Aurélien, additional, Daniel, Matthieu, additional, Sharshar, Tarek, additional, Cadoz, Cyril, additional, Gaci, Rostane, additional, Gette, Sébastien, additional, Louis, Guillaune, additional, Sacleux, Sophe-Caroline, additional, Ordan, Marie-Amélie, additional, Cravoisy, Aurélie, additional, Conrad, Marie, additional, Courte, Guilhem, additional, Gibot, Sébastien, additional, Benzidi, Younès, additional, Casella, Claudia, additional, Serpin, Laurent, additional, Setti, Jean-Lou, additional, Besse, Marie-Catherine, additional, Bourreau, Anna, additional, Pillot, Jérôme, additional, Rivera, Caroline, additional, Vinclair, Camille, additional, Robaux, Marie-Aline, additional, Achino, Chloé, additional, Delignette, Marie-Charlotte, additional, Mazard, Tessa, additional, Aubrun, Frédéric, additional, Bouchet, Bruno, additional, Frérou, Aurélien, additional, Muller, Laura, additional, Quentin, Charlotte, additional, Degoul, Samuel, additional, Stihle, Xavier, additional, Sumian, Claude, additional, Bergero, Nicoletta, additional, Lanaspre, Bernard, additional, Quintard, Hervé, additional, Marie Maiziere, Eve, additional, Egreteau, Pierre-Yves, additional, Leloup, Guillaume, additional, Berteau, Florin, additional, Cottrel, Marjolaine, additional, Bouteloup, Marie, additional, Jeannot, Matthieu, additional, Blanc, Quentin, additional, Saison, Julien, additional, Geneau, Isabelle, additional, Grenot, Romaric, additional, Ouchike, Abdel, additional, Hazera, Pascal, additional, Masse, Anne-Lyse, additional, Demiri, Suela, additional, Vezinet, Corinne, additional, Baron, Elodie, additional, Benchetrit, Deborah, additional, Monsel, Antoine, additional, Trebbia, Grégoire, additional, Schaack, Emmanuelle, additional, Lepecq, Raphaël, additional, Bobet, Mathieu, additional, Vinsonneau, Christophe, additional, Dekeyser, Thibault, additional, Delforge, Quentin, additional, Rahmani, Imen, additional, Vivet, Bérengère, additional, Paillot, Jonathan, additional, Hierle, Lucie, additional, Chaignat, Claire, additional, Valette, Sarah, additional, Her, Benoït, additional, Brunet, Jennifier, additional, Page, Mathieu, additional, Boiste, Fabienne, additional, Collin, Anthony, additional, Bavozet, Florent, additional, Garin, Aude, additional, Dlala, Mohamed, additional, Mhamdi, Kais, additional, Beilouny, Bassem, additional, Lavalard, Alexandra, additional, Perez, Severine, additional, Veber, Benoit, additional, Guitard, Pierre-Gildas, additional, Gouin, Philippe, additional, Lamacz, Anna, additional, Plouvier, Fabienne, additional, P Delaborde, Bertrand, additional, Kherchache, Aïssa, additional, Chaalal, Amina, additional, Amouretti, Marc, additional, Freita-Ramos, Santiago, additional, Roux, Damien, additional, Constantin, Jean-Michel, additional, Assefi, Mona, additional, Lecore, Marine, additional, Selves, Agathe, additional, Prevost, Florian, additional, Lamer, Christian, additional, Shi, Ruiying, additional, Knani, Lyes, additional, Pili Floury, Sébastien, additional, Vettoretti, Lucie, additional, Levy, Michael, additional, Marsac, Lucile, additional, Dauger, Stéphane, additional, Guilmin-Crépon, Sophie, additional, Winiszewski, Hadrien, additional, Piton, Gael, additional, Soumagne, Thibaud, additional, Capellier, Gilles, additional, Putegnat, Jean-Baptiste, additional, Bayle, Frédérique, additional, Perrou, Maya, additional, Thao, Ghyslaine, additional, Géri, Guillaume, additional, Charron, Cyril, additional, Repessé, Xavier, additional, Vieillard-Baron, Antoine, additional, Guilbart, Mathieu, additional, Roger, Pierre-Alexandre, additional, Hinard, Sébastien, additional, Macq, Pierre-Yves, additional, Chaulier, Kevin, additional, Goutte, Sylvie, additional, Chillet, Patrick, additional, Pitta, Anaïs, additional, Darjent, Barbara, additional, Bruneau, Amandine, additional, Lasocki, Sigismond, additional, Leger, Maxime, additional, Gergaud, Soizic, additional, Lemarie, Pierre, additional, Terzi, Nicolas, additional, Schwebel, Carole, additional, Dartevel, Anaïs, additional, Galerneau, Louis-Marie, additional, Diehl, Jean-Luc, additional, Hauw-Berlemont, Caroline, additional, Péron, Nicolas, additional, Guérot, Emmanuel, additional, Mohebbi Amoli, Abolfazl, additional, Benhamou, Michel, additional, Deyme, Jean-Pierre, additional, Andremont, Olivier, additional, Lena, Diane, additional, Cady, Julien, additional, Causeret, Arnaud, additional, De La Chapelle, Arnaud, additional, Cracco, Christophe, additional, Rouleau, Stéphane, additional, Schnell, David, additional, Foucault, Camille, additional, Lory, Cécile, additional, Chapelle, Thibault, additional, Bruckert, Vincent, additional, Garcia, Julie, additional, Sahraoui, Abdlazize, additional, Abbosh, Nathalie, additional, Bornstain, Caroline, additional, Pernet, Pierre, additional, Poirson, Florent, additional, Pasem, Ahmed, additional, Karoubi, Philippe, additional, Poupinel, Virginie, additional, Gauthier, Caroline, additional, Bouniol, François, additional, Feuchere, Philippe, additional, Heron, Anne, additional, Carreira, Serge, additional, Emery, Malo, additional, Sophie Le Floch, Anne, additional, Giovannangeli, Luana, additional, Herzog, Nicolas, additional, Giacardi, Christophe, additional, Baudic, Thibaut, additional, Thill, Chloé, additional, Lebbah, Said, additional, Palmyre, Jessica, additional, Tubach, Florence, additional, Hajage, David, additional, Bonnet, Nicolas, additional, Ebstein, Nathan, additional, Gaudry, Stéphane, additional, Cohen, Yves, additional, Noublanche, Julie, additional, Lesieur, Olivier, additional, Sément, Arnaud, additional, Roca-Cerezo, Isabel, additional, Pascal, Michel, additional, Sma, Nesrine, additional, Colin, Gwenhaël, additional, Lacherade, Jean-Claude, additional, Bionz, Gauthier, additional, Maquigneau, Natacha, additional, Bouzat, Pierre, additional, Durand, Michel, additional, Hérault, Marie-Christine, additional, and Payen, Jean-Francois, additional
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- 2022
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22. International Virtual Simulation Education in Critical Care During COVID-19 Pandemic: Preliminary Description of the Virtual Checklist for Early Recognition and Treatment of Acute Illness and iNjury Program
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Flurin, Laure, primary, Tekin, Aysun, additional, Bogojevic, Marija, additional, Zec, Simon, additional, Sun, Yuqiang, additional, Li, Heyi, additional, Finch, Alexander, additional, Ahmad, Sumera, additional, Kashyap, Rahul, additional, Gajic, Ognjen, additional, Niven, Alexander S., additional, and Dong, Yue, additional
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- 2022
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23. Targeted Metagenomic Sequencing-based Approach Applied to 2146 Tissue and Body Fluid Samples in Routine Clinical Practice
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Flurin, Laure, primary, Wolf, Matthew J, additional, Mutchler, Melissa M, additional, Daniels, Matthew L, additional, Wengenack, Nancy L, additional, and Patel, Robin, additional
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- 2022
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24. Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study
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Massart, Nicolas, Maxime, Virginie, Fillatre, Pierre, Razazi, Keyvan, Ferré, Alexis, Moine, Pierre, Legay, Francois, Voiriot, Guillaume, Amara, Marlene, Santi, Francesca, Nseir, Saad, Marque-Juillet, Stephanie, Bounab, Rania, Barbarot, Nicolas, Bruneel, Fabrice, Luyt, Charles-Edouard, Mercat, Alain, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pham, Tài, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Demoule, Alexandre, Dres, Martin, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Fartoukh, Muriel, Teulier, Marion, Blayau, Clarisse, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Déserts, Marc Danguy Des, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Reignier, Jean, Seguin, Amélie, Garret, Charlotte, Canet, Emmanuel, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Girault, Christophe, Gissot, Valérie, Ehrmann, Stéphan, Gandonniere, Charlotte Salmon, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallo, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Lemoine, Ludivine Chalumeau, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Schmidt, Matthieu, Combes, Alain, Chommeloux, Juliette, Luyt, Charles Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Mahler, Juliette Courtiade, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Kimmoun, Antoine, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre Julien, Esnault, Pierre, Cardinale, Mickael, Ha, Vivien Hong Tuan, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Burtz, Catherine Paugam, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fayolle, Pierre-Marie, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Dinh, Alexy Tran, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, de Prost, Nicolas, Mongardon, Nicolas, Lamraoui, Meriam, Alessandri, Claire, de Roux, Quentin, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Oufella, Hafid Ait, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Jouan, Mélanie Saint, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Ricard, Jean-Damien, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Floury, Sébastien Pili, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Amoli, Abolfazl Mohebbi, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Lebbah, Said, Palmyre, Jessica, Tubach, Florence, Hajage, David, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Centre hospitalier Saint-Brieuc, Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CHU Henri Mondor [Créteil], Centre Hospitalier de Versailles André Mignot (CHV), CHU Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), INSERM UMRS-1144, Université Paris Cité, Réanimation Médicale et Toxicologique, Hôpital Lariboisière, COVID ICU Bacteremia Study Group on behalf of the COVID-ICU Investigators, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Henri Mondor, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN], and Mégarbane, Bruno
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[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,RC86-88.9 ,Research ,Correction ,Medical emergencies. Critical care. Intensive care. First aid ,bacterial infections and mycoses ,Critical Care and Intensive Care Medicine ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,human activities - Abstract
Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring intensive care unit (ICU) have a high incidence of hospital-acquired infections; however, data regarding hospital acquired bloodstream infections (BSI) are scarce. We aimed to investigate risk factors and outcome of BSI in critically ill coronavirus infectious disease-19 (COVID-19) patients. Patients and methods We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU study) that included 4010 COVID-19 ICU patients. For the present analysis, only those with data regarding primary outcome (death within 90 days from admission) or BSI status were included. Risk factors for BSI were analyzed using Fine and Gray competing risk model. Then, for outcome comparison, 537 BSI-patients were matched with 537 controls using propensity score matching. Results Among 4010 included patients, 780 (19.5%) acquired a total of 1066 BSI (10.3 BSI per 1000 patients days at risk) of whom 92% were acquired in the ICU. Higher SAPS II, male gender, longer time from hospital to ICU admission and antiviral drug before admission were independently associated with an increased risk of BSI, and interestingly, this risk decreased over time. BSI was independently associated with a shorter time to death in the overall population (adjusted hazard ratio (aHR) 1.28, 95% CI 1.05–1.56) and, in the propensity score matched data set, patients with BSI had a higher mortality rate (39% vs 33% p = 0.036). BSI accounted for 3.6% of the death of the overall population. Conclusion COVID-19 ICU patients have a high risk of BSI, especially early after ICU admission, risk that increases with severity but not with corticosteroids use. BSI is associated with an increased mortality rate.
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- 2021
25. Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals
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Schmidt, Matthieu, Demoule, Alexandre, Hajage, David, Pham, Tài, Combes, Alain, Dres, Martin, Lebbah, Said, Kimmoun, Antoine, Mercat, Alain, Beduneau, Gaëtan, Palmyre, Jessica, Prevost, Margot, Ricard, Jean-Damien, Ferré, Alexis, Fayolle, Pierre-Marie, Girault, Christophe, Pradel, Gael, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Voiriot, Guillaume, Fartoukh, Muriel, Teulier, Marion, Blayau, Clarisse, L’her, Erwen, Aubron, Cécile, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Nseir, Saad, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Des Déserts, Marc Danguy, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Jean, Reignier, Amélie, Seguin, Charlotte, Garret, Emmanuel, Canet, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Gissot, Valérie, Ehrmann, Stéphan, Gandonniere, Charlotte Salmon, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Bruneel, Fabrice, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallot, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Lemoine, Ludivine Chalumeau, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Chommeloux, Juliette, Luyt, Charles Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Mahler, Juliette Courtiade, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sqébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Barbarot, Nicolas, Fillatre, Pierre, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre Julien, Esnault, Pierre, Cardinale, Mickael, Ha, Vivien Hong Tuan, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Burtz, Catherine Paugam, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Dinh, Alexy Tran, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, Razazi, Keyvan, de Prost, Nicolas, Mongardon, Nicolas, Langeron, Olivier, Levesque, Eric, Attias, Arié, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Oufella, Hafid Ait, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Santi, Francesca, Moine, Pierre, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Jouan, Mélanie Saint, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Floury, Sébastien Pili, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Amoli, Abolfazl Mohebbi, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Tubach, Florence, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), COVID-ICU group, for the REVA network, COVID-ICU investigators, and Mégarbane, Bruno
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Critical Care and Intensive Care Medicine ,Acute respiratory failure ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Risk Assessment ,Mechanical ventilation ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Prospective Studies ,Mortality ,Outcome ,[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Noninvasive Ventilation ,Acute respiratory distress syndrome ,RC86-88.9 ,Research ,COVID-19 ,Medical emergencies. Critical care. Intensive care. First aid ,Hospitals ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,Intensive Care Units ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,High-flow nasal cannula ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Intubation - Abstract
Rational To evaluate the respective impact of standard oxygen, high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) on oxygenation failure rate and mortality in COVID-19 patients admitted to intensive care units (ICUs). Methods Multicenter, prospective cohort study (COVID-ICU) in 137 hospitals in France, Belgium, and Switzerland. Demographic, clinical, respiratory support, oxygenation failure, and survival data were collected. Oxygenation failure was defined as either intubation or death in the ICU without intubation. Variables independently associated with oxygenation failure and Day-90 mortality were assessed using multivariate logistic regression. Results From February 25 to May 4, 2020, 4754 patients were admitted in ICU. Of these, 1491 patients were not intubated on the day of ICU admission and received standard oxygen therapy (51%), HFNC (38%), or NIV (11%) (P P P = 0.013) but not NIV (OR 1.57, 95% CI 0.78–3.21) was associated with a reduction in oxygenation failure). Overall 90-day mortality was 21%. By multivariable analysis, HFNC was not associated with a change in mortality (OR 0.90, 95% CI 0.61–1.33), while NIV was associated with increased mortality (OR 2.75, 95% CI 1.79–4.21, P Conclusion In patients with COVID-19, HFNC was associated with a reduction in oxygenation failure without improvement in 90-day mortality, whereas NIV was associated with a higher mortality in these patients. Randomized controlled trials are needed.
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- 2021
26. Hydrogen-peroxide generating electrochemical bandage is active in vitro against mono- and dual-species biofilms
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Raval, Yash S., primary, Mohamed, Abdelrhman, additional, Flurin, Laure, additional, Mandrekar, Jayawant N., additional, Greenwood Quaintance, Kerryl E., additional, Beyenal, Haluk, additional, and Patel, Robin, additional
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- 2021
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27. Targeted Versus Shotgun Metagenomic Sequencing-based Detection of Microorganisms in Sonicate Fluid for Periprosthetic Joint Infection Diagnosis.
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Hong, Hyo-Lim, Flurin, Laure, Thoendel, Matthew J, Wolf, Matthew J, Abdel, Matthew P, Greenwood-Quaintance, Kerryl E, and Patel, Robin
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RNA analysis , *SEQUENCE analysis , *TOTAL hip replacement , *TOTAL knee replacement , *CELL culture , *MICROBIOLOGY , *PHENOMENOLOGICAL biology , *SURGERY , *PATIENTS , *ARTIFICIAL joints , *INFECTION , *TREATMENT failure , *GENOMICS , *DESCRIPTIVE statistics , *RESEARCH funding , *STATISTICAL sampling , *POLYMERASE chain reaction , *PROSTHESIS-related infections , *SYNOVIAL fluid , *RNA probes - Abstract
Background Next-generation sequencing (NGS) is increasingly used for periprosthetic joint infection (PJI) diagnosis, but its clinical utility is poorly defined. Shotgun metagenomic sequencing (sNGS) has been reported to identify PJI pathogens undetected by culture in sonicate fluid. However, sNGS is complex and costly. Here, 16S ribosomal RNA (rRNA) gene-based targeted metagenomic sequencing (tNGS) was compared to sNGS of sonicate fluid for microbial detection and identification in patients with total hip arthroplasty (THA) and total knee arthroplasty (TKA) failure. Methods A convenience sample of sonicate fluids derived from patients who had undergone THA or TKA removal, enriched with culture negative PJI cases, was tested. Samples had been previously tested by sNGS. For tNGS, samples were extracted, amplified by polymerase chain reaction targeting the V1 to V3 regions of the 16S rRNA gene, and sequenced on an Illumina MiSeq. Results A total of 395 sonicate fluids, including 208 from subjects with PJI, were studied. Compared with sonicate fluid culture, tNGS had higher positive percent agreement (72.1 vs 52.9%, P <.001), detecting potential pathogens in 48.0% of culture-negative PJIs. There was no difference between the positive percent agreement of tNGS (72.1%) and sNGS (73.1%, P =.83). Conclusions 16S rRNA gene-based tNGS is a potential diagnostic tool for PJI pathogen identification in sonicate fluid from failed THAs and TKAs in culture-negative cases, with similar performance characteristics to sNGS. [ABSTRACT FROM AUTHOR]
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- 2023
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28. Activity of a hypochlorous acid‐producing electrochemical bandage as assessed with a porcine explant biofilm model.
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Tibbits, Gretchen, Mohamed, Abdelrhman, Gelston, Suzanne, Flurin, Laure, Raval, Yash S., Greenwood‐Quaintance, Kerryl E., Patel, Robin, and Beyenal, Haluk
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The activity of a hypochlorous acid‐producing electrochemical bandage (e‐bandage) in preventing methicillin‐resistant Staphylococcus aureus infection (MRSA) infection and removing biofilms formed by MRSA was assessed using a porcine explant biofilm model. e‐Bandages inhibited S. aureus infection (p = 0.029) after 12 h (h) of exposure and reduced 3‐day biofilm viable cell counts after 6, 12, and 24 h exposures (p = 0.029). Needle‐type microelectrodes were used to assess HOCl concentrations in explant tissue as a result of e‐bandage treatment; toxicity associated with e‐bandage treatment was evaluated. HOCl concentrations in infected and uninfected explant tissue varied between 30 and 80 µM, decreasing with increasing distance from the e‐bandage. Eukaryotic cell viability was reduced by an average of 71% and 65% in fresh and day 3‐old explants, respectively, when compared to explants exposed to nonpolarized e‐bandages. HOCl e‐bandages are a promising technology that can be further developed as an antibiotic‐free treatment for wound biofilm infections. [ABSTRACT FROM AUTHOR]
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- 2023
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29. Antibiofilm Activity of a Tunable Hypochlorous Acid‐Generating Electrochemical Bandage Controlled by a Wearable Potentiostat.
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Mohamed, Abdelrhman, Raval, Yash S., Gelston, Suzanne, Tibbits, Gretchen, Ay, Suat U., Flurin, Laure, Greenwood-Quaintance, Kerryl E., Patel, Robin, and Beyenal, Haluk
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ANTIMICROBIAL bandages ,BANDAGES & bandaging ,CHRONIC wounds & injuries ,POTENTIOSTAT ,ELECTRODE potential ,ACINETOBACTER baumannii ,STAPHYLOCOCCUS aureus - Abstract
Chronic wound biofilm infections represent a major clinical challenge which results in a substantial burden to patients and healthcare systems. Treatment with topical antibiotics is oftentimes ineffective as a result of antibiotic‐resistant microorganisms and biofilm‐specific antibiotic tolerance. Use of biocides such as hypochlorous acid (HOCl) has gained increasing attention due to the lack of known resistance mechanisms. An HOCl‐generating electrochemical bandage (e‐bandage) is designed that delivers HOCl continuously at low concentrations targeting infected wound beds in a similar manner to adhesive antimicrobial wound dressings. A battery‐operated wearable potentiostat is developed that controls the e‐bandage electrodes at potentials suitable for HOCl generation. It is demonstrated that e‐bandage treatment is tunable by changing the applied potential. HOCl generation on electrode surfaces is verified using microelectrodes. The developed e‐bandage shows time‐dependent responses against in vitro Acinetobacter baumannii and Staphylococcus aureus biofilms, reducing viable cells to nondetectable levels within 6 and 12 h of treatment, respectively. The developed e‐bandage should be further evaluated as an alternative to topical antibiotics to treat wound biofilm infections. [ABSTRACT FROM AUTHOR]
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- 2023
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30. Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores
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Schmidt, Matthieu, Guidet, Bertrand, Demoule, Alexandre, Ponnaiah, Maharajah, Fartoukh, Muriel, Puybasset, Louis, Combes, Alain, Hajage, David, Mercat, Alain, Asfar, Pierre, Beloncle, François, Demiselle, Julien, Pham, Tài, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Dres, Martin, Mayaux, Julien, Beurton, Alexandra, Daubin, Cédric, Descamps, Richard, Joret, Aurélie, Du Cheyron, Damien, Pene, Frédéric, Chiche, Jean-Daniel, Jozwiak, Mathieu, Jaubert, Paul, Voiriot, Guillaume, Teulier, Marion, Blayau, Clarisse, L’her, Erwen, Aubron, Cécile, Bodenes, Laetitia, Ferriere, Nicolas, Auchabie, Johann, Le Meur, Anthony, Pignal, Sylvain, Mazzoni, Thierry, Quenot, Jean-Pierre, Andreu, Pascal, Roudau, Jean-Baptiste, Labruyère, Marie, Nseir, Saad, Preau, Sébastien, Poissy, Julien, Mathieu, Daniel, Benhamida, Sarah, Paulet, Rémi, Roucaud, Nicolas, Thyrault, Martial, Daviet, Florence, Hraiech, Sami, Parzy, Gabriel, Sylvestre, Aude, Jochmans, Sébastien, Bouilland, Anne-Laure, Monchi, Mehran, Danguy Des Déserts, Marc, Mathais, Quentin, Rager, Gwendoline, Pasquier, Pierre, Jean, Reignier, Amélie, Seguin, Charlotte, Garret, Emmanuel, Canet, Dellamonica, Jean, Saccheri, Clément, Lombardi, Romain, Kouchit, Yanis, Jacquier, Sophie, Mathonnet, Armelle, Nay, Mai-Ahn, Runge, Isabelle, Martino, Frédéric, Flurin, Laure, Rolle, Amélie, Carles, Michel, Coudroy, Rémi, Thille, Arnaud, Frat, Jean-Pierre, Rodriguez, Maeva, Beuret, Pascal, Tientcheu, Audrey, Vincent, Arthur, Michelin, Florian, Tamion, Fabienne, Carpentier, Dorothée, Boyer, Déborah, Girault, Christophe, Gissot, Valérie, Ehrmann, Stéphan, Salmon Gandonniere, Charlotte, Elaroussi, Djlali, Delbove, Agathe, Fedun, Yannick, Huntzinger, Julien, Lebas, Eddy, Kisoka, Grâce, Grégoire, Céline, Marchetta, Stella, Lambermont, Bernard, Argaud, Laurent, Baudry, Thomas, Bertrand, Pierre-Jean, Dargent, Auguste, Guitton, Christophe, Chudeau, Nicolas, Landais, Mickaël, Darreau, Cédric, Ferre, Alexis, Gros, Antoine, Lacave, Guillaume, Bruneel, Fabrice, Neuville, Mathilde, Devaquet, Jérôme, Tachon, Guillaume, Gallot, Richard, Chelha, Riad, Galbois, Arnaud, Jallot, Anne, Chalumeau Lemoine, Ludivine, Kuteifan, Khaldoun, Pointurier, Valentin, Jandeaux, Louise-Marie, Mootien, Joy, Damoisel, Charles, Sztrymf, Benjamin, Chommeloux, Juliette, Luyt, Charles-Edouard, Schortgen, Frédérique, Rusel, Leon, Jung, Camille, Gobert, Florent, Vimpere, Damien, Lamhaut, Lionel, Sauneuf, Bertrand, Charrrier, Liliane, Calus, Julien, Desmeules, Isabelle, Painvin, Benoît, Tadie, Jean-Marc, Castelain, Vincent, Michard, Baptiste, Herbrecht, Jean-Etienne, Baldacini, Mathieu, Weiss, Nicolas, Demeret, Sophie, Marois, Clémence, Rohaut, Benjamin, Moury, Pierre-Henri, Savida, Anne-Charlotte, Couadau, Emmanuel, Série, Mathieu, Alexandru, Nica, Bruel, Cédric, Fontaine, Candice, Garrigou, Sonia, Courtiade Mahler, Juliette, Leclerc, Maxime, Ramakers, Michel, Garçon, Pierre, Massou, Nicole, van Vong, Ly, Sen, Juliane, Lucas, Nolwenn, Chemouni, Franck, Stoclin, Annabelle, Avenel, Alexandre, Faure, Henri, Gentilhomme, Angélie, Ricome, Sylvie, Abraham, Paul, Monard, Céline, Textoris, Julien, Rimmele, Thomas, Montini, Florent, Lejour, Gabriel, Lazard, Thierry, Etienney, Isabelle, Kerroumi, Younes, Dupuis, Claire, Bereiziat, Marine, Coupez, Elisabeth, Thouy, François, Hoffmann, Clément, Donat, Nicolas, Chrisment, Anne, Blot, Rose-Marie, Kimmoun, Antoine, Jacquot, Audrey, Mattei, Matthieu, Levy, Bruno, Ravan, Ramin, Dopeux, Loïc, Liteaudon, Jean-Mathias, Roux, Delphine, Rey, Brice, Anghel, Radu, Schenesse, Deborah, Gevrey, Vincent, Castanera, Jermy, Petua, Philippe, Madeux, Benjamin, Hartman, Otto, Piagnerelli, Michael, Joosten, Anne, Noel, Cinderella, Biston, Patrick, Noel, Thibaut, Bouar, Gurvan, Boukhanza, Messabi, Demarest, Elsa, Bajolet, Marie-France, Charrier, Nathanaël, Quenet, Audrey, Zylberfajn, Cécile, Dufour, Nicolas, Mégarbane, Buno, Voicu, Sqébastian, Deye, Nicolas, Malissin, Isabelle, Legay, François, Debarre, Matthieu, Barbarot, Nicolas, Fillatre, Pierre, Delord, Bertrand, Laterrade, Thomas, Saghi, Tahar, Pujol, Wilfried, Cungi, Pierre-Julien, Esnault, Pierre, Cardinale, Mickael, Hong Tuan Ha, Vivien, Fleury, Grégory, Brou, Marie-Ange, Zafimahazo, Daniel, Tran-Van, David, Avargues, Patrick, Carenco, Lisa, Robin, Nicolas, Ouali, Alexandre, Houdou, Lucie, Le Terrier, Christophe, Suh, Noémie, Primmaz, Steve, Pugin, Jérome, Weiss, Emmanuel, Gauss, Tobias, Moyer, Jean-Denis, Paugam Burtz, Catherine, La Combe, Béatrice, Smonig, Rolland, Violleau, Jade, Cailliez, Pauline, Chelly, Jonathan, Marchalot, Antoine, Saladin, Cécile, Bigot, Christelle, Fayolle, Pierre-Marie, Fatséas, Jules, Ibrahim, Amr, Resiere, Dabor, Hage, Rabih, Cholet, Clémentine, Cantier, Marie, Trouiler, Pierre, Montravers, Philippe, Lortat-Jacob, Brice, Tanaka, Sebastien, Tran Dinh, Alexy, Duranteau, Jacques, Harrois, Anatole, Dubreuil, Guillaume, Werner, Marie, Godier, Anne, Hamada, Sophie, Zlotnik, Diane, Nougue, Hélène, Mekontso-Dessap, Armand, Carteaux, Guillaume, Razazi, Keyvan, de Prost, Nicolas, Mongardon, Nicolas, Langeron, Olivier, Levesque, Eric, Attias, Arié, de Roquetaillade, Charles, Chousterman, Benjamin, Mebazaa, Alexandre, Gayat, Etienne, Garnier, Marc, Pardo, Emmanuel, Satre-Buisson, Lea, Gutton, Christophe, Yvin, Elise, Marcault, Clémence, Azoulay, Elie, Darmon, Michael, Ait Oufella, Hafid, Hariri, Geoffroy, Urbina, Tomas, Mazerand, Sandie, Heming, Nicholas, Santi, Francesca, Moine, Pierre, Annane, Djillali, Bouglé, Adrien, Omar, Edris, Lancelot, Aymeric, Begot, Emmanuelle, Plantefeve, Gaétan, Contou, Damien, Mentec, Hervé, Pajot, Olivier, Faguer, Stanislas, Cointault, Olivier, Lavayssiere, Laurence, Nogier, Marie-Béatrice, Jamme, Matthieu, Pichereau, Claire, Hayon, Jan, Outin, Hervé, Dépret, François, Coutrot, Maxime, Chaussard, Maité, Guillemet, Lucie, Goffin, Pierre, Thouny, Romain, Guntz, Julien, Jadot, Laurent, Persichini, Romain, Jean-Michel, Vanessa, Georges, Hugues, Caulier, Thomas, Pradel, Gaël, Hausermann, Marie-Hélène, Nguyen-Valat, Thi My Hue, Boudinaud, Michel, Vivier, Emmanuel, Rosseli, Sylvène, Bourdin, Gaël, Pommier, Christian, Vinclair, Marc, Poignant, Simon, Mons, Sandrine, Bougouin, Wulfran, Bruna, Franklin, Maestraggi, Quentin, Roth, Christian, Bitker, Laurent, Dhelft, François, Bonnet-Chateau, Justine, Filippelli, Mathilde, Morichau-Beauchant, Tristan, Thierry, Stéphane, Le Roy, Charlotte, Saint Jouan, Mélanie, Goncalves, Bruno, Mazeraud, Aurélien, Daniel, Matthieu, Sharshar, Tarek, Cadoz, Cyril, Gaci, Rostane, Gette, Sébastien, Louis, Guillaune, Sacleux, Sophe-Caroline, Ordan, Marie-Amélie, Cravoisy, Aurélie, Conrad, Marie, Courte, Guilhem, Gibot, Sébastien, Benzidi, Younès, Casella, Claudia, Serpin, Laurent, Setti, Jean-Lou, Besse, Marie-Catherine, Bourreau, Anna, Pillot, Jérôme, Rivera, Caroline, Vinclair, Camille, Robaux, Marie-Aline, Achino, Chloé, Delignette, Marie-Charlotte, Mazard, Tessa, Aubrun, Frédéric, Bouchet, Bruno, Frérou, Aurélien, Muller, Laura, Quentin, Charlotte, Degoul, Samuel, Stihle, Xavier, Sumian, Claude, Bergero, Nicoletta, Lanaspre, Bernard, Quintard, Hervé, Maiziere, Eve Marie, Egreteau, Pierre-Yves, Leloup, Guillaume, Berteau, Florin, Cottrel, Marjolaine, Bouteloup, Marie, Jeannot, Matthieu, Blanc, Quentin, Saison, Julien, Geneau, Isabelle, Grenot, Romaric, Ouchike, Abdel, Hazera, Pascal, Masse, Anne-Lyse, Demiri, Suela, Vezinet, Corinne, Baron, Elodie, Benchetrit, Deborah, Monsel, Antoine, Trebbia, Grégoire, Schaack, Emmanuelle, Lepecq, Raphaël, Bobet, Mathieu, Vinsonneau, Christophe, Dekeyser, Thibault, Delforge, Quentin, Rahmani, Imen, Vivet, Bérengère, Paillot, Jonathan, Hierle, Lucie, Chaignat, Claire, Valette, Sarah, Her, Benoït, Brunet, Jennifier, Page, Mathieu, Boiste, Fabienne, Collin, Anthony, Bavozet, Florent, Garin, Aude, Dlala, Mohamed, Mhamdi, Kais, Beilouny, Bassem, Lavalard, Alexandra, Perez, Severine, Veber, Benoit, Guitard, Pierre-Gildas, Gouin, Philippe, Lamacz, Anna, Plouvier, Fabienne, Delaborde, Bertrand, Kherchache, Aïssa, Chaalal, Amina, Ricard, Jean-Damien, Amouretti, Marc, Freita-Ramos, Santiago, Roux, Damien, Constantin, Jean-Michel, Assefi, Mona, Lecore, Marine, Selves, Agathe, Prevost, Florian, Lamer, Christian, Shi, Ruiying, Knani, Lyes, Pili Floury, Sébastien, Vettoretti, Lucie, Levy, Michael, Marsac, Lucile, Dauger, Stéphane, Guilmin-Crépon, Sophie, Winiszewski, Hadrien, Piton, Gael, Soumagne, Thibaud, Capellier, Gilles, Putegnat, Jean-Baptiste, Bayle, Frédérique, Perrou, Maya, Thao, Ghyslaine, Géri, Guillaume, Charron, Cyril, Repessé, Xavier, Vieillard-Baron, Antoine, Guilbart, Mathieu, Roger, Pierre-Alexandre, Hinard, Sébastien, Macq, Pierre-Yves, Chaulier, Kevin, Goutte, Sylvie, Chillet, Patrick, Pitta, Anaïs, Darjent, Barbara, Bruneau, Amandine, Lasocki, Sigismond, Leger, Maxime, Gergaud, Soizic, Lemarie, Pierre, Terzi, Nicolas, Schwebel, Carole, Dartevel, Anaïs, Galerneau, Louis-Marie, Diehl, Jean-Luc, Hauw-Berlemont, Caroline, Péron, Nicolas, Guérot, Emmanuel, Mohebbi Amoli, Abolfazl, Benhamou, Michel, Deyme, Jean-Pierre, Andremont, Olivier, Lena, Diane, Cady, Julien, Causeret, Arnaud, de la Chapelle, Arnaud, Cracco, Christophe, Rouleau, Stéphane, Schnell, David, Foucault, Camille, Lory, Cécile, Chapelle, Thibault, Bruckert, Vincent, Garcia, Julie, Sahraoui, Abdlazize, Abbosh, Nathalie, Bornstain, Caroline, Pernet, Pierre, Poirson, Florent, Pasem, Ahmed, Karoubi, Philippe, Poupinel, Virginie, Gauthier, Caroline, Bouniol, François, Feuchere, Philippe, Heron, Anne, Carreira, Serge, Emery, Malo, Le Floch, Anne Sophie, Giovannangeli, Luana, Herzog, Nicolas, Giacardi, Christophe, Baudic, Thibaut, Thill, Chloé, Lebbah, Said, Palmyre, Jessica, Tubach, Florence, Bonnet, Nicolas, Ebstein, Nathan, Gaudry, Stéphane, Cohen, Yves, Noublanche, Julie, Lesieur, Olivier, Sément, Arnaud, Roca-Cerezo, Isabel, Pascal, Michel, Sma, Nesrine, Colin, Gwenhaël, Lacherade, Jean-Claude, Bionz, Gauthier, Maquigneau, Natacha, Bouzat, Pierre, Durand, Michel, Hérault, Marie-Christine, Payen, Jean-Francois, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aigüE [CHU Pitié-Salpêtrière] (GRC RESPIRE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Département Médico-Universitaire APPROCHES, CHU Tenon [AP-HP], Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Henri Mondor, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Pharmacoépidémiologie de l'AP-HP (Cephepi), INSERM UMRS-1144, Université Paris Cité, Réanimation Médicale et Toxicologique, Hôpital Lariboisière, and Mégarbane, Bruno
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[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Acute respiratory distress syndrome ,RC86-88.9 ,Research ,COVID-19 ,Medical emergencies. Critical care. Intensive care. First aid ,Critical Care and Intensive Care Medicine ,Predictive survival model ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,Mechanical ventilation ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Outcome - Abstract
Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was to develop predictive survival models for patients with COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, and outcomes of critically ill patients with COVID-19. Machine learning was used to develop dynamic, clinically useful models able to predict 90-day mortality using ICU data collected on day (D) 1, D7 or D14. Results Survival of Severely Ill COVID (SOSIC)-1, SOSIC-7, and SOSIC-14 scores were constructed with 4244, 2877, and 1349 patients, respectively, randomly assigned to development or test datasets. The three models selected 15 ICU-entry variables recorded on D1, D7, or D14. Cardiovascular, renal, and pulmonary functions on prediction D7 or D14 were among the most heavily weighted inputs for both models. For the test dataset, SOSIC-7’s area under the ROC curve was slightly higher (0.80 [0.74–0.86]) than those for SOSIC-1 (0.76 [0.71–0.81]) and SOSIC-14 (0.76 [0.68–0.83]). Similarly, SOSIC-1 and SOSIC-7 had excellent calibration curves, with similar Brier scores for the three models. Conclusion The SOSIC scores showed that entering 15 to 27 baseline and dynamic clinical parameters into an automatable XGBoost algorithm can potentially accurately predict the likely 90-day mortality post-ICU admission (sosic.shinyapps.io/shiny). Although external SOSIC-score validation is still needed, it is an additional tool to strengthen decisions about life-sustaining treatments and informing family members of likely prognosis.
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- 2021
31. 773. Hypochlorous Acid Generating Electrochemical Catheter Prototype for Prevention of Intraluminal Infections
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Flurin, Laure, primary, Cano Cevallos, Edison J, additional, Mohamed, Abdelrhman, additional, Greenwood-Quaintance, Kerryl, additional, Raval, Yash, additional, Beyenal, Haluk, additional, and Patel, Robin, additional
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- 2021
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32. Hypochlorous Acid-Generating Electrochemical Catheter Prototype for Prevention of Intraluminal Infection
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Cano, Edison J., primary, Flurin, Laure, additional, Mohamed, Abdelrhman, additional, Greenwood-Quaintance, Kerryl E., additional, Raval, Yash S., additional, Beyenal, Haluk, additional, and Patel, Robin, additional
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- 2021
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33. CERTAIN Program: Logic Model for System Level Planning and Evaluation of Innovative Education Delivery and Dissemination
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Sun, Yuqiang, primary, Li, Heyi, additional, Tekin, Aysun, additional, Bogojevic, Marija, additional, Flurin, Laure, additional, Heise, Katherine, additional, Kashyap, Rahul, additional, Finch, Alexander, additional, Niven, Alexander, additional, Gajic, Ognjen, additional, and Dong, Yue, additional
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- 2021
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34. Predictive modeling in neurocritical care using causal artificial intelligence
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Dang, Johnny, primary, Lal, Amos, additional, Flurin, Laure, additional, James, Amy, additional, Gajic, Ognjen, additional, and Rabinstein, Alejandro A, additional
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- 2021
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35. Three-Dimensional Navigation (O-arm) for Minimally Invasive Shelf Acetabuloplasty
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Severyns, Mathieu, Andeol, Quentin, Flurin, Laure, Abdellatif, Kerim, Cazor, Antoine, Vendeuvre, Tanguy, Hostalrich, Francois-Xavier, Benchikh El-Fegoun, Abdelkrim, and Odri, Guillaume Anthony
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- 2020
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36. Decompressive craniectomy as a rescue treatment in Herpes simplex encephalitis-related cerebral edema: a case report and literature review
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Malhomme, Rémi, primary, Pommier, Jean-David, additional, Flurin, Laure, additional, Carles, Michel, additional, and Do, Laurent, additional
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- 2021
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37. Hydrogen peroxide‐producing electrochemical bandage controlled by a wearable potentiostat for treatment of wound infections
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Mohamed, Abdelrhman, primary, Anoy, MD Monzurul Islam, additional, Tibbits, Gretchen, additional, Raval, Yash S., additional, Flurin, Laure, additional, Greenwood‐Quaintance, Kerryl E., additional, Patel, Robin, additional, and Beyenal, Haluk, additional
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- 2021
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38. In Vitro Antibacterial Activity of Hydrogen Peroxide and Hypochlorous Acid, Including That Generated by Electrochemical Scaffolds
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Raval, Yash S., primary, Flurin, Laure, additional, Mohamed, Abdelrhman, additional, Greenwood-Quaintance, Kerryl E., additional, Beyenal, Haluk, additional, and Patel, Robin, additional
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- 2021
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39. An Integrated HOCl-Producing E-Scaffold Is Active against Monomicrobial and Polymicrobial Biofilms
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Flurin, Laure, primary, Raval, Yash S., additional, Mohamed, Abdelrhman, additional, Greenwood-Quaintance, Kerryl E., additional, Cano, Edison J., additional, Beyenal, Haluk, additional, and Patel, Robin, additional
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- 2021
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40. A Tale of a Two Waves Epidemic: Characteristics and Mortality Risk Factors for COVID-19 ICU Patients in the French West Indies
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Pommier, jean-david, primary, Martino, frederic, additional, Bleakley, Kevin, additional, Flurin, Laure, additional, Roy, Fabien Van, additional, Carles, michel, additional, Valette, marc, additional, and camous, laurent, additional
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- 2021
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41. 324. Implant Sonication Improves Microbiologic Diagnosis of Elbow Prosthetic Joint Infection
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Flurin, Laure, primary, Greenwood-Quaintance, Kerryl, additional, Esper, Ronda N, additional, Sanchez-Sotelo, Joachin, additional, and Patel, Robin, additional
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- 2020
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42. In VitroAntibacterial Activity of Hydrogen Peroxide and Hypochlorous Acid, Including That Generated by Electrochemical Scaffolds
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Raval, Yash S., Flurin, Laure, Mohamed, Abdelrhman, Greenwood-Quaintance, Kerryl E., Beyenal, Haluk, and Patel, Robin
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Hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) are biocides used for cleaning and debriding chronic wound infections, which often harbor drug-resistant bacteria. Here, we evaluated the in vitroactivity of H2O2and HOCl against 27 isolates of eight bacterial species involved in wound infections.
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- 2021
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43. 291: DEVELOPING DELPHI EXPERT CONSENSUS RULES FOR A DIGITAL TWIN MODEL OF THE NEURO CRITICAL CARE UNIT.
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Dang, Johnny, Lal, Amos, Rabinstein, Alejandro, Gajic, Ognjen, Flurin, Laure, Montgomery, Amy, and Litell, John
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- 2023
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44. 59: PREDICTION MODEL TO IDENTIFY SEPSIS PATIENTS FOR MINIMALLY INVASIVE MANAGEMENT OUTSIDE THE ICU.
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Wahab, Abdul, Smith, Ryan, Lal, Amos, Flurin, Laure, Malinchoc, Michael, Dong, Yue, and Gajic, Ognjen
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- 2023
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45. 16S rRNA Gene PCR/Sequencing of Heart Valves for Diagnosis of Infective Endocarditis in Routine Clinical Practice.
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Hong HL, Flurin L, Greenwood-Quaintance KE, Wolf MJ, Pritt BS, Norgan AP, and Patel R
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- Humans, RNA, Ribosomal, 16S genetics, Genes, rRNA, Sequence Analysis, DNA methods, DNA, Bacterial genetics, DNA, Bacterial analysis, Heart Valves microbiology, Polymerase Chain Reaction methods, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial microbiology, Endocarditis diagnosis, Endocarditis microbiology
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Sequencing is increasingly used for infective endocarditis (IE) diagnosis. Here, the performance of 16S rRNA gene PCR/sequencing of heart valves utilized in routine clinical practice was compared with conventional IE diagnostics. Subjects whose heart valves were sent to the clinical microbiology laboratory for 16S rRNA gene PCR/sequencing from August 2020 through February 2022 were studied. A PCR assay targeting V1 to V3 regions of the 16S rRNA gene was performed, followed by Sanger and/or next-generation sequencing (NGS) (using an Illumina MiSeq), or reported as negative, depending on an algorithm that included the PCR cycle threshold value. Fifty-four subjects, including 40 with IE, three with cured IE, and 11 with noninfective valvular disease, were studied. Thirty-one positive results, 11 from NGS and 20 from Sanger sequencing, were generated from analysis of 16S rRNA gene sequence(s). Positivity rates of blood cultures and 16S rRNA gene PCR/sequencing of valves were 55% and 75%, respectively ( P = 0.06). In those with prior antibiotic exposure, positivity rates of blood cultures and 16S rRNA gene PCR/sequencing of valves were 11% and 76%, respectively ( P < 0.001). Overall, 61% of blood culture-negative IE subjects had positive valve 16S rRNA gene PCR/sequencing results. 16S rRNA gene-based PCR/sequencing of heart valves is a useful diagnostic tool for pathogen identification in patients with blood culture-negative IE undergoing valve surgery in routine clinical practice., Competing Interests: The authors declare no conflict of interest.
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- 2023
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46. Anti-Biofilm Activity of a Tunable Hypochlorous Acid-Generating Electrochemical Bandage Controlled By a Wearable Potentiostat.
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Mohamed A, Raval YS, Gelston S, Tibbits G, Ay SU, Flurin L, Greenwood-Quaintance KE, Patel R, and Beyenal H
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Chronic wound biofilm infections represent a major clinical challenge which results in a substantial burden to patients and healthcare systems. Treatment with topical antibiotics is oftentimes ineffective as a result of antibiotic-resistant microorganisms and biofilm-specific antibiotic tolerance. Use of biocides such as hypochlorous acid (HOCl) has gained increasing attention due to the lack of known resistance mechanisms. We designed an HOCl-generating electrochemical bandage (e-bandage) that delivers HOCl continuously at low concentrations targeting infected wound beds in a similar manner to adhesive antimicrobial wound dressings. We developed a battery-operated wearable potentiostat that controls the e-bandage electrodes at potentials suitable for HOCl generation. We demonstrated that e-bandage treatment was tunable by changing the applied potential. HOCl generation on electrode surfaces was verified using microelectrodes. The developed e-bandage showed time-dependent responses against in vitro Acinetobacter baumannii and Staphylococcus aureus biofilms, reducing viable cells to non-detectable levels within 6 and 12 hours of treatment, respectively. The developed e-bandage should be further evaluated as an alternative to topical antibiotics to treat wound biofilm infections., Competing Interests: Conflict of Interests Dr. Patel reports grants from ContraFect, TenNor Therapeutics Limited, and BioFire. Dr. Patel is a consultant to PhAST, Torus Biosystems, Day Zero Diagnostics, Mammoth Biosciences, and HealthTrackRx; monies are paid to Mayo Clinic. Mayo Clinic and Dr. Patel have a relationship with Pathogenomix. Dr. Patel has research supported by Adaptive Phage Therapeutics. Mayo Clinic has a royalty-bearing know-how agreement and equity in Adaptive Phage Therapeutics. Dr. Patel is also a consultant to Netflix, Abbott Laboratories, and CARB-X. In addition, Dr. Patel has a patent on Bordetella pertussis/parapertussis PCR issued, a patent on a device/method for sonication with royalties paid by Samsung to Mayo Clinic, and a patent on an anti-biofilm substance issued. Dr. Patel receives honoraria from the NBME, Up-to-Date and the Infectious Diseases Board Review Course.
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- 2023
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47. International Virtual Simulation Education in Critical Care During COVID-19 Pandemic: Preliminary Description of the Virtual Checklist for Early Recognition and Treatment of Acute Illness and iNjury Program.
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Flurin L, Tekin A, Bogojevic M, Zec S, Sun Y, Li H, Finch A, Ahmad S, Kashyap R, Gajic O, Niven AS, and Dong Y
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Summary Statement: The Checklist for Early Recognition and Treatment of Acute Illness and iNjury program is a well-established, interactive, and simulation-based program designed to improve the quality of care delivered in intensive care units. The COVID-19 pandemic created an overwhelming surge of critically ill patients worldwide, and infection control concerns limited healthcare providers' access to in-person and hands-on simulation training when they needed it the most. Virtual simulation offers an alternative to in-person training but is often complex and expensive. We describe our successful development and initial implementation of an inexpensive, simulation-based virtual Checklist for Early Recognition and Treatment of Acute Illness and iNjury program to address the pressing need for effective critical care training in various resource-limited settings both within and outside of the United States. The overall satisfaction rate ("excellent" or "very good" responses) was 94.4% after the virtual simulation workshop. Our initial experience suggests that virtual interactions can be engaging and build strong relationships, like in-person continuing professional education, even using relatively simple technology. This knowledge-to-practice improvement platform can be readily adapted to other disciplines beyond critical care medicine., Competing Interests: Y.D. received remote simulation research grant from Mayo Clinic. O.G. has financial conflict of interest with CERTAIN software platforms licensed to Ambient Clinical Analytics. O.G. also received an education grant from the World Health Organization Office in Sarajevo, Bosnia and Herzegovina. R.K. receives funding from the National Institutes of Health/National Heart, Lung and Blood Institute (R01HL 130881, UG3/UH3HL 141722), Gordon and Betty Moore Foundation, and Janssen Research & Development, LLC; and royalties from Ambient Clinical Analytics, Inc. They had no influence on acquisition, analysis, interpretation, and reporting of pooled data for this article. The other authors declare no conflict of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society for Simulation in Healthcare.)
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- 2022
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48. in vitro Activity of Hydrogen Peroxide and Hypochlorous Acid Generated by Electrochemical Scaffolds Against Planktonic and Biofilm Bacteria.
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Raval YS, Flurin L, Mohamed A, Greenwood-Quaintance KE, Beyenal H, and Patel R
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Hydrogen peroxide (H
2 O2 ) and hypochlorous acid (HOCl) are biocides used for cleaning and debriding chronic wound infections, which often harbor drug resistant bacteria. Here, we evaluated the in vitro activity of H2 O2 and HOCl against 27 isolates of eight bacterial species involved in wound infections. Minimum inhibitory concentrations (MICs) and minimum biofilm bactericidal concentrations (MBBCs) were measured. When compared to their respective MICs, MBBCs of isolates exposed to H2 O2 were 16- to 1,024-fold higher and those exposed to HOCl were 2- to 4-fold higher. We evaluated selection of resistance after exposure of Staphylococcus aureus and Pseudomonas aeruginosa biofilms to 10 iterations of electrochemically generated HOCl or H2 O2 delivered using electrochemical scaffolds (e-scaffolds), observing no decrease in anti-biofilm effects with serial exposure to e-scaffold-generated H2 O2 or HOCl. 24-hour exposure to H2 O2 -generating e-scaffolds consistently decreased colony forming units (CFUs) of S. aureus and P. aeruginosa biofilms by ∼5.0-log10 and ∼4.78-log10 through 10 iterations of exposure, respectively. 4-hour exposure to HOCl-generating e-scaffolds consistently decreased CFUs of S. aureus biofilms by ∼4.9-log10 , and 1-hour exposure to HOCl-generating e-scaffolds consistently decreased CFUs of P. aeruginosa biofilms by ∼1.57-log10 These results suggest that HOCl has similar activity against planktonic and biofilm bacteria, whereas the activity of H2 O2 is less against biofilm than planktonic bacteria, and that repeat exposure to either biocide, generated electrochemically under the experimental conditions studied, does not lessen antibiofilm effects., (Copyright © 2021 American Society for Microbiology.)- Published
- 2021
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