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Abstract Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disease. However, some patients may exhibit a histological pattern of kidney injury, with characteristics indistinguishable from lupus nephritis, but without presenting any extrarenal symptoms or serologies suggestive of SLE. Such involvement has recently been called non-lupus full-house nephropathy. The objective is to report a series of clinical cases referred to the Laboratory of the Federal University of Maranhão that received the diagnosis of "full-house" nephropathy unrelated to lupus, upon immunofluorescence and to discuss its evolution and outcomes. Non-lupus full-house nephropathy represents a diagnostic and therapeutic challenge, because it is a new entity, which still needs further studies and may be the initial manifestation of SLE, isolated manifestation of SLE or a new pathology unrelated to SLE.

This study examined the distribution of P. gingivalis, P. intermedia and B. forsythus in plaque on metallic and porcelain panties adjacent to healthy and inflamed mucosa. Subpontic plaque was collected from 33 inflamed and 31 healthy sites. Plaque suspension was incubated with specific rabbit antisera to P. gingivalis (FDC 381). P. intermedia (ATCC 25261) and B. forsythus (FDC 335), and the labelled cells disclosed with fluorescein-labelled goat-anti-rabbit IgG by indirect immunofluorescence microscopy. Mean proportions of P. gingivalis, P. intermedia and B. forsythus at inflamed sites were 0.60±0.75. 2.48±2.28, and 0.44=0.64% respectively, and at healthy sites 0.21 ±0.43. 1.27± 1.05. and 0.15±0.18% respectively. These differences were statistically significant. Almost all sites were positive for P. intermedia, whereas only 18/31 healthy and 21/33 inflamed sites were positive for P. gingivalis 18/31 healthy and 28/33 inflamed sites were positive for B. forsythus P. intermedia was recovered in higher proportions from metallic pontics adjacent to inflamed sites (MI) than healthy sites (MM) or porcelain pontics next to inflamed (Pl) or healthy sites (PH). P. gingivalis is was recovered in higher proportions from MI than PH. We conclude that both the nature of the pontic material and the health status of the mucosa affect the composition of the associated microbiota. [ABSTRACT FROM AUTHOR]