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3. Anesthetic care of a patient with succinic semi-aldehyde dehydrogenase deficiency.

Author

Flowers, J., Veneziano, G., Cambier, G., and Tobias, J. D.

Subjects
*PEDIATRIC anesthesia, *GABA, *GENETIC disorders
Abstract

Succinic semialdehyde dehydrogenase (SSADH) deficiency is an uncommon autosomal recessive disorder that affects the degradation of gamma-aminobutyric acid (GABA) within the central nervous system (CNS). Clinical manifestations generally present during infancy including hypotonia, developmental delay, cognitive impairment, expressive language deficits, and ataxia. Seizures are a hallmark of the disorder, being present in approximately half of affected individuals. Given the multisystem involvement of these patients with a high incidence of associated seizures, anesthetic care may be required for diagnostic imaging or therapeutic interventions. We present a 23-year-old woman with SSADH deficiency who required anesthetic care during dental surgery. The basic pathophysiology and inheritance of SSADH is presented, clinical manifestations and end-organ involvement reviewed, and potential anesthetic implications outlined. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Components of Mathematics Teacher Training

Author

Liljedahl, Peter, Durand-Guerrier, V., Winsløw, C., Bloch, I., Huckstep, P., Rowland, T., Thwaites, A., Grevholm, B., Bergsten, C., Adler, J., Davis, Z., Garcia, M., Sánchez, V., Proulx, J., Flowers, J., Rubenstein, R., Grant, T., Kline, K., Moreira, P., David, M., Opolot-Okurut, C., Chapman, O., Artigue, Michèle, editor, Hodgson, Bernard R., editor, Even, Ruhama, editor, and Ball, Deborah Loewenberg, editor

Published
2009
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5. Laser Spectroscopy of the 2S Lamb Shift in Hydrogenic Silicon

Author

Klein, H. A., Margolis, H. S., Flowers, J. L., Gaarde-Widdowson, K., Hosaka, K., Silver, J. D., Tarbutt, M. R., Ohtani, S., Knight, D. J. E., Beig, R., editor, Ehlers, J., editor, Frisch, U., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Kippenhahn, R., editor, Lipowsky, R., editor, Löhneysen, H. v., editor, Ojima, I., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Karshenboim, Savely G., editor, Bassani, F., editor, Pavone, F.S., editor, Inguscio, M., editor, and Hänsch, T.W., editor

Published
2001
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11. Data Management Plans: The Importance of Data Management in the BIG‐MAP Project

Author

Castelli, I.E., Arismendi-Arrieta, D.J., Bhowmik, A., Cekic-Laskovic, I., Clark, S., Dominko, Robert, Flores, E., Flowers, J., Ulvskov Frederiksen, K., Friis, J., Grimaud, A., Vels Hansen, K., Hardwick, L.J., Hermansson, K., Königer, L., Lauritzen, H., Cras, F. le, Li, H., Lyonnard, S., Lorrmann, Henning, Marzari, N., Niedzicki, L., Pizzi, G., Rahmanian, F., Stein, H., Uhrin, M., Wenzel, W., Winter, M., Wölke, C., Vegge, T., and Publica

Subjects
data curation, FAIR data, batteries, database, data management plan
Abstract

Open access to research data is increasingly important for accelerating research. Grant authorities therefore request detailed plans for how data is managed in the projects they finance. We have recently developed such a plan for the EU−H2020 BIG-MAP project-a cross-disciplinary project targeting disruptive battery-material discoveries. Essential for reaching the goal is extensive sharing of research data across scales, disciplines and stakeholders, not limited to BIG-MAP and the European BATTERY 2030+ initiative but within the entire battery community. The key challenges faced in developing the data management plan for such a large and complex project were to generate an overview of the enormous amount of data that will be produced, to build an understanding of the data flow within the project and to agree on a roadmap for making all data FAIR (findable, accessible, interoperable, reusable). This paper describes the process we followed and how we structured the plan.

Published
2021

17. Components of Mathematics Teacher Training

Author

Liljedahl, Peter, primary, Durand-Guerrier, V., additional, Winsløw, C., additional, Bloch, I., additional, Huckstep, P., additional, Rowland, T., additional, Thwaites, A., additional, Grevholm, B., additional, Bergsten, C., additional, Adler, J., additional, Davis, Z., additional, Garcia, M., additional, Sánchez, V., additional, Proulx, J., additional, Flowers, J., additional, Rubenstein, R., additional, Grant, T., additional, Kline, K., additional, Moreira, P., additional, David, M., additional, Opolot-Okurut, C., additional, and Chapman, O., additional

Published
2009
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18. An Update on Prognostic Value of Changes in Neutrophil-To-Lymphocyte Ratio (NLR), Platelet-To-Lymphocyte Ratio (PLR) and Lymphocyte-To-Monocyte Ratio (LMR) for Patients with Cervical Cancer Undergoing Definitive Chemoradiotherapy (dCRT)

Author

Trinh, H., primary, Jang, H., additional, Kim, S., additional, Hyder, J., additional, Chen, J., additional, Flowers, J., additional, Vaishampayan, N.G., additional, Winer, I., additional, and Miller, S.R., additional

Published
2020
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25. 1992 Scientific Session of the Society of American Gastrointestinal Surgeons (SAGES) Washington, D.C., USA, April 11–12, 1992

Author

Salky, Barry, Bauer, Joel, Easter, D. W., Cuschieri, A., Lavelle-Jones, M., Nathanson, L., Brandt, C. P., Priebe, P. P., Eckhauser, M. L., Henriques, III, Horace F., Deziel, Daniel J., Millikan, Keith W., Staren, Edgar D., Economou, Steven G., Lexer, G. W., Lexer, G. Ch., Lehofer, F., Meiser, G., Boeckl, O., Williams, Mark D., Murr, Peter C., Shimomura, Kazuyuki, Ohtomo, Yumiko, Ishizaki, Yoichi, Noie, Tamaki, Abe, Hideki, Nayeem, Sarder Abdun, Bandai, Yasutsugu, Idezuki, Yasuo, Kam, David, Scheeres, David, Nagai, Hideo, Kondo, Yasuo, Yasuda, Toshihiko, Kasahara, Kogoro, Kanazawa, Kyotaro, Wittgen, C. M., Andrus, J. P., Andrus, C. H., Kaminski, D. L., Fried, G. M., Sigman, H. H., Meakins, J. L., Hinchey, E. J., Garzon, J., Barkun, J. S., Mamazza, J., Wexler, M. J., Bordelon, B. M., Hobday, K. A., Hunter, J. G., Saunders, C. J., Gardiner, B., Leary, B. F., F. N. P., Frey, C. F., Wolfe, B. M., Kozarek, R. A., Traverso, L. W., Ball, T. J., Brandabur, J., Jolly, P. C., Patterson, D. J., Ryan, J. A., Thirlby, R. C., Wechter, D. G., Hunter, J. A., Fletcher, D. P., Molnar, Robert G., Apelgren, Keith N., Kisala, John M., Way, Lawrence W., Wetter, Albert, Pietrafitta, Joseph J., Schultz, Leonard S., Graber, John N., Hickok, David F., Congreve, D., Zinnecker, H., Lohmuller, J., Legrand, M., Detroz, B., Honore, P., Jacquet, N., Yamamoto, M., Stiegmann, G., Durham, J., Berguer, R., Fujiyama, Y., Oba, Y., Downey, J., Miho, O., Green, P., Satava, R., Hill, J., Simon, I., Brodish, R. J., Soper, Nathaniel J., Dunnegan, Deanna L., Peters, Jeffrey H., Innes, Jeffrey T., Front, Mary E., Ellison, E. Christopher, Swanstrom, Lee, Sangster, William, Stoker, Mark E., Phillips, E., Carroll, B., Fallas, M., Daykhovsky, L., Murphy, B., Miller, S., Keiter, N., Halpern, Norman B., Escudero-Fabre, Angel, Sack, Jonathan, Himal, H. S., Luchette F., Doerr R., Kulaylat M., Stephan R., Kelly K., Fowler, Dennis L., White, Sharon A., Church, James M., De Paula, A. L., Hashiba, K., Ambroze, Jr, W. L., Nezhat, C., Nezhat, F., Orangio, G., Brooks, D. C., Becker, J. M., Connors, P. J., Carr-Locke, D. L., Adams, D. B., Borowicz, M. R., Wootton, III, F. T., Cunningham, J. T., Cirocco, W. C., Rusin, L. C., Franceschi, Dido, Pritchard, Timothy, Eckhauser, Marc, Estes, J. M., Szabo, Z., Harrison, M. R., Krishnan, S. M., Goh, P. M. Y., Ambroze, Jr., W. L., Orangio, G. R., Tucker, J. G., Baird, D., Herndon, M., Lucas, G. W., Bell, R. C. W., Stiegmann, G. V., Sun, J., Kim, J., Lucia, M. S., Bender, J. S., Talamini, M. A., Bessler, Marc, Treat, Michael R., Canady, J., Nicolo, E., Jagdeo, C., McQueen, J., Fontana, F., Dewitty, R., Castellano, M., Elmann, E. M., Lobbato, V. J., Cosgrove, John M., Franklin, Howard, Margolis, Irving B., de la Torre, R., Donahue, PE, Schlesinger, P., Sluss, K., Attar, B., Nyhus, L. M., Anan, K., Fletcher, D. R., Flowers, J. L., Zucker, K. A., Graham, S. M., Scovill, W. A., Imbembo, A. L., Bailey, R. W., Gagner, M., Rheault, M., Dubuc, J., Ghobrial, Rafik, MacFadyen, Jr., Bruce V., Catalano, Mark, Raijman, Isaac, Haicken, Barry N., Daijo, Hashimoto, Shuji, Kajiwara, Takanobu, Hoshino, Fukuyo, Tsuneo, Kitano, S., Moriyama, M., Sugimachi, K., Kudo, Shin-ei, Kusaka, Takashi, Nakajima, Kouji, Kimata, Hiroyuki, Miura, Kouji, Takano, Yukio, Lamphier, Jonathan B., Diflo, Thomas, Kondi, Edward S., Larson, G. M., Vitale, G. C., Voight, W., Cheadle, W., Miller, F., Leahy, P. F., Pennino, R. P., Furman, R. H., Libutti, Steven K., Williams, Mathew R., Litwin, D., Johnson, D., Osachoff, J., Gallagher, C., Church, D., Mansour, M. A., Martin, Matt B., Abrams, Arkin, Ballen, Blievernicht, Bowman, Davis, Farley, Hoxworth, Ingram, Leone, Lindsey, Newman, Price, Streck, Weatherly, Young, Miscusi, Route G., Masoni, L., Gasparrini, M., Montori, A., Montori, A., Munakata, Y., Kawasaki, S., Hashikura, Y., Hashimoto, S., Hayashi, K., Numata, M., Makuuchi, M., Mustafa, I. A., Reed, W. P., Coe, N. P. W., Leigh H., Nadler, Nelson, M. T., Nakashima, M., Mulvihill, S. J., Olsen, Douglas O., Corbitt, John D., Edleman, David S., Unger, Stephen, Unger, Harold, Orkin, B. A., Smith, L. E., Paz-Partlow, M., Berci, G., Sackier, J. M., Miller, John, Kieth E., Nichols, Ollila, David, Gibbons, Gregory E., Davanzo, Mark A., Polacek, Michael A., Pons, R., Grannan, K., Welling, R., Pritchard, Timothy J., Richards, William O., Unger, S. W., Rosenbaum, G., Unger, H. M., Edelman, D. S., Schirmer, B. D., Dix, J., Schmieg, Jr., R. E., Aguilar, M., Schirmer, B. D., Dix, J., Scott, T. R., Zucker, K. A., Bailey, R. W., Bergstein, J. M., Seone, D., Wittmann, D. H., Quebbeman, E. J., Aprahamian, C., McGrath, Michael, Shapiro, Stephen, Gordon, Leo, Adashek, Kenneth, Daykhovsky, Leon, Shoop, Stephen A., Sackier, Jonathan, Meakin, J. L., Snyder, Samuel K., Symmonds, Richard E., Roberts, John W., Hendricks, John C., Smith, Randall W., Frazee, Richard C., Soper, Nathaniel J., Brunt, L. Michael, Fleshman, James, Meininger, Thomas A., Dunnegan, Deanna L., RN, Sudan, Debra, Mellinger, John, Miller, Sidney, Sugawa, C., Lucas, C. E., Szabo, Zoltan, Berci, George, Hunter, John G., Unger, S. W., Unger, H. M., Edelman, D. S., Weaver, Donald W., Bouwman, David, Tyburski, James, and Wierson, T. A.

Published
1992
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30. Changes in health in the countries of the UK and 150 English Local Authority areas 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Steel, N, Ford, JA, Newton, JN, Davis, ACJ, Vos, T, Naghavi, M, Glenn, S, Hughes, A, Dalton, AM, Stockton, D, Humphreys, C, Dallat, M, Schmidt, J, Flowers, J, Fox, S, Abubakar, I, Aldridge, RW, Baker, A, Brayne, C, Brugha, T, Capewell, S, Car, J, Cooper, C, Ezzati, M, Fitzpatrick, J, Greaves, F, Hay, R, Hay, S, Kee, F, Larson, HJ, Lyons, RA, Majeed, A, McKee, M, Rawaf, S, Rutter, H, Saxena, S, Sheikh, A, Smeeth, L, Viner, RM, Vollset, SE, Williams, HC, Wolfe, C, Woolf, A, Murray, CJL, Brayne, Carol [0000-0001-5307-663X], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Adolescent, Health Status, Article, Global Burden of Disease, Disability Evaluation, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, Risk Factors, General & Internal Medicine, Cause of Death, Poverty Areas, Humans, Disabled Persons, Mortality, Child, Aged, Medicine(all), Aged, 80 and over, Infant, Newborn, Infant, 11 Medical And Health Sciences, Health Status Disparities, Middle Aged, United Kingdom, Socioeconomic Factors, Child, Preschool, Female, Quality-Adjusted Life Years
Abstract

Background: Previous studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and risks at country and local levels. The slowdown in the rate of improvement in life expectancy requires further investigation. We use GBD 2016 data on mortality, causes of death, and disability to analyse the burden of disease in the countries of the UK and within local authorities in England by deprivation quintile. Methods: We extracted data from the GBD 2016 to estimate years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and attributable risks from 1990 to 2016 for England, Scotland, Wales, Northern Ireland, the UK, and 150 English Upper-Tier Local Authorities. We estimated the burden of disease by cause of death, condition, year, and sex. We analysed the association between burden of disease and socioeconomic deprivation using the Index of Multiple Deprivation. We present results for all 264 GBD causes of death combined and the leading 20 specific causes, and all 84 GBD risks or risk clusters combined and 17 specific risks or risk clusters. Findings: The leading causes of age-adjusted YLLs in all UK countries in 2016 were ischaemic heart disease, lung cancers, cerebrovascular disease, and chronic obstructive pulmonary disease. Age-standardised rates of YLLs for all causes varied by two times between local areas in England according to levels of socioeconomic deprivation (from 14 274 per 100 000 population [95% uncertainty interval 12 791–15 875] in Blackpool to 6888 [6145–7739] in Wokingham). Some Upper-Tier Local Authorities, particularly those in London, did better than expected for their level of deprivation. Allowing for differences in age structure, more deprived Upper-Tier Local Authorities had higher attributable YLLs for most major risk factors in the GBD. The population attributable fractions for all-cause YLLs for individual major risk factors varied across Upper-Tier Local Authorities. Life expectancy and YLLs have improved more slowly since 2010 in all UK countries compared with 1990–2010. In nine of 150 Upper-Tier Local Authorities, YLLs increased after 2010. For attributable YLLs, the rate of improvement slowed most substantially for cardiovascular disease and breast, colorectal, and lung cancers, and showed little change for Alzheimer's disease and other dementias. Morbidity makes an increasing contribution to overall burden in the UK compared with mortality. The age-standardised UK DALY rate for low back and neck pain (1795 [1258–2356]) was higher than for ischaemic heart disease (1200 [1155–1246]) or lung cancer (660 [642–679]). The leading causes of ill health (measured through YLDs) in the UK in 2016 were low back and neck pain, skin and subcutaneous diseases, migraine, depressive disorders, and sense organ disease. Age-standardised YLD rates varied much less than equivalent YLL rates across the UK, which reflects the relative scarcity of local data on causes of ill health. Interpretation: These estimates at local, regional, and national level will allow policy makers to match resources and priorities to levels of burden and risk factors. Improvement in YLLs and life expectancy slowed notably after 2010, particularly in cardiovascular disease and cancer, and targeted actions are needed if the rate of improvement is to recover. A targeted policy response is also required to address the increasing proportion of burden due to morbidity, such as musculoskeletal problems and depression. Improving the quality and completeness of available data on these causes is an essential component of this response. Funding: Bill & Melinda Gates Foundation and Public Health England.

Published
2018
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35. fingertipsR: an R package for accessing population health information in England

Author

Flint D, Hain D, Flowers J, Simon Thelwall, and Fox S

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Computer science, Public health, Population, Population health, Data science, Mental health, World Wide Web, Health services, Epidemiology, Health care, medicine, business, education
Abstract

Fingertips is a major public repository of population and public health indicators for England, built and maintained by Public Health England (PHE). The indicators are arranged in thematic or topical profiles covering a wide range of health issues including:broad Health Profilesspecific topics such as liver disease and end of liferisk factors including alcohol, smoking, physical activitypopulation healthcare health services data for general practices, cancer, mental healthhealth protection data on general health protection, TB, antimicrobial resistancelifecourse profiles for younger and older peoplemortality and morbidity.Fingertips makes data available for more than 1,500 indicators spread across more than 70 profiles. The data can be accessed from https://fingertips.phe.org.uk where the data are visualised in variety of ways including heatmaps, choropleth maps, line charts for trends, “spine” charts (graphs which compare multiple indicators for a single geographic area), scatter plots and so on. Data can be obtained as downloads or figures which can be exported or cut and paste into reports and slides.A recent addition to the Fingertips platform was an Automated Programming Interface (API) to enable developers to re-use the data. To facilitate access to Fingertips data we have designed an R package - fingertipsR - enabling rapid and easy access to the data by analysts and data scientists. The package is available from the Comprehensive R Archive Network (CRAN).This paper describes the fingertipsR package which provides tools accessing a wide range of public health data for England from the Fingertips website using its API.

Published
2017
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37. Familiarity, Redundancy, and the Spatial Control of Visual Attention.

Author

Flowers, J. H.

Abstract

Familiar letter sequences in noncued portions of a tachistoscopic display were shown to reduce accuracy of partial report. Findings suggest that familiarity may automatically direct attentional resources to a particular spatial region. Such attentional capture may be disruptive if the material is presented at another location. (Author/RD)

Published
1981

38. Magnetic resonance studies of chemically intercalated Li[sub x]V[sub 2]O[sub 5] aerogels.

Author

Stallworth, P. E., Johnson, F. S., Greenbaum, S. G., Passerini, S., Flowers, J., and Smyrl, W.

Subjects
MAGNETIC resonance, AEROGELS
Abstract

[sup 7]Li, [sup 51]V solid-state nuclear magnetic resonance (NMR) and electron paramagnetic resonance (ERR) measurements have been performed upon chemically lithiated Li[sub x]V[sub 2]O[sub 5] aerogels, with compositions of 1.00

Published
2002
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43. Readers' Column

Author

Flowers, J. Royce, Lewis, Dorothy M., Kuner, Harry, Hupp, Wilfred A., Claxton, Myron, Goldberg, Alfred L., and Reber, Paul

Published
1958

45. DIGEST.

Author

Frant, R. D., Roland, C. C., Schempp, P., Levine, L., Maki, B. E., Rosen, J. H., Simon, R., George, P., Goodman, L., Shephard, R., Montelpare, W., Berridge, M., Flowers, J., Stinson, S. W., Epstein, L. H., Wing, R. R., Koeske, R., Valoski, A., Hefley, R. D., and Gorman, D. R.

Subjects
PHYSICAL education for people with disabilities, HEARING impaired, PHYSICAL education for children with disabilities, PHYSICAL fitness for people with disabilities, ADVENTURE education, OUTDOOR education, BIOMECHANICS
Abstract

This section presents information on articles related to adapted physical activity. The articles include "Learning through outdoor adventure education," found in an issue of "Teaching Exceptional Children," "Hemispheric specialization and implications for the education of the hearing impaired," found in an issue of "American Annals of the Deaf," and "Modification of spastic gait through mechanical damping," found in an issue of the "Journal of Biomechanics."

Published
1987

46. Magnetic resonance studies of chemically intercalated Li(sub x)V2O5 aerogels

Author

Stallworth, P.E., Johnson, F.S., Greenbaum, S.G., Passerini, S., Smyrl, W., and Flowers, J.

Subjects
Magnetic resonance -- Research, Aerogels -- Structure, Aerogels -- Electric properties, Physics
Abstract

Structural and dynamical studies of aerogel (ARG) materials is discussed. The presence of oxidized impurities or electronic charge delocalization is indicated.

Published
2002

49. UNRAVELING THE TAXONOMY OF A CRYPTIC SEA STAR COMPLEX (LEPTASTERIAS SPP.) WITH MUSEUM DNA

Author

Flowers, J. M. and Foltz, D.W.

Subjects
Zoological research -- Analysis, Starfishes -- Genetic aspects
Abstract

The taxonomy of six-rayed sea stars in the genus Leptasterias subgenus Hexasterias has been controversial for more than a century. The most recent monographic treatment of this genus (Fisher, 1930) proposed the existence of freely hybridizing taxa that are questionable on modem evolutionary grounds. To resolve some of the taxonomic confusion, molecular methods were applied to Fisher-identified museum voucher specimens. DNA was extracted from 75 to 100 year-old dried specimens using a series of glycine-based washes. Genus-specific primers were used to PCR-amplify 180 base pairs or a hypervariable sequence within the putative control region of the mitochondrial genome. The apparent relationship between Fisher-identified specimens and molecular haplotypes allows the use of an extensive allozyme dataset to determine the taxonomic status of Fisher's proposed species and forms. The high success rate of this method minimizes the destruction of valuable museum material and provides alternative means for solving a complex taxonomic problem. The results to date suggest that many of Fishers subspecies and forms are probably full species.

Published
1998

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