6,290 results on '"Flowers, P."'
Search Results
2. Longitudinal associations between microRNAs and weight in the diabetes prevention program
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Flowers, Elena, Stroebel, Benjamin, Lewis, Kimberly A, Aouizerat, Bradley E, Gadgil, Meghana, Kanaya, Alka M, Zhang, Li, and Gong, Xingyue
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Biomedical and Clinical Sciences ,Clinical Sciences ,Behavioral and Social Science ,Clinical Research ,Nutrition ,Biotechnology ,Genetics ,Diabetes ,Obesity ,Prevention ,2.1 Biological and endogenous factors ,Cardiovascular ,Metabolic and endocrine ,Cancer ,Good Health and Well Being ,Nutrition and Dietetics ,Clinical sciences - Abstract
Objective: Circulating microRNAs show cross-sectional associations with overweight and obesity. Few studies provided data to differentiate between a snapshot perspective on these associations versus how microRNAs characterize prodromal risk from disease pathology and complications. This study assessed longitudinal relationships between circulating microRNAs and weight at multiple time-points in the Diabetes Prevention Program trial. Research design and methods: A subset of participants (n=150) from the Diabetes Prevention Program were included. MicroRNAs were measured from banked plasma using a Fireplex Assay. We used generalized linear mixed models to evaluate relationships between microRNAs and changes in weight at baseline, year-1, and year-2. Logistic regression was used to evaluate whether microRNAs at baseline were associated with weight change after 2 years. Results: In fully adjusted models that included relevant covariates, seven miRs (i.e., miR-126, miR-15a, miR-192, miR-23a, and miR-27a) were statistically associated with weight over 2 years. MiR-197 and miR-320a remained significant after adjustment for multiple comparisons. Baseline levels of let-7f, miR-17, and miR-320c were significantly associated with 3% weight loss after 2 years in fully adjusted models. Discussion: This study provided evidence for longitudinal relationships between circulating microRNAs and weight. Because microRNAs characterize the combined effects of genetic determinants and responses to behavioral determinants, they may provide insights about the etiology of overweight and obesity in the context or risk for common, complex diseases. Additional studies are needed to validate the potential genes and biological pathways that might be targeted by these microRNA biomarkers and have mechanistic implications for weight loss and disease prevention.
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- 2024
3. The Experiences of Sexual and Gender Minority Participants With a Remote Biospecimen Collection Protocol
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Panyanouvong, Nicholas, Lella, Paavani, Sunder, Gowri, Lubensky, Micah E, Dastur, Zubin, E. Aouizerat, Bradley, E. Lisha, Nadra, B. Neilands, Torsten, Flowers, Elena, Lunn, Mitchell R, Obedin-Maliver, Juno, and Flentje, Annesa
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Health Services and Systems ,Health Sciences ,Basic Behavioral and Social Science ,Minority Health ,Social Determinants of Health ,Behavioral and Social Science ,Health Disparities ,Clinical Research ,Sexual and Gender Minorities (SGM/LGBT*) ,Good Health and Well Being - Abstract
Sexual and gender minority (SGM) communities are underrepresented in biomedical studies, highlighting the importance of developing biospecimen collection protocols aimed at engaging SGM participants. We aimed to learn more about SGM participants’ experiences with a remote (i.e., not performed at a central location) biospecimen collection study pioneered by The PRIDE Study, a cohort study of SGM adults residing in the United States and its territories. Feedback was collected from 112 SGM participants following blood donation for a parent study investigating the relationship between minority stress, substance use, and epigenetic markers of substance use and minority stress. We used an inductive and collaborative approach to qualitative analysis and identified major themes and areas for protocol improvement. Major themes among participant feedback were as follows: (1) communication with the research team, (2) convenience of donation, (3) interactions with clinical laboratory staff, and (4) anonymity and privacy. Most participants indicated that they experienced little to no problems during the donation process and expressed approval for the clarity and transparency of the informed consent process, ease of communication with the research team, and measures taken to protect participant confidentiality during their appointment. The most common challenges encountered by participants related to the inconvenience of handling and transporting study materials to the clinical laboratory site and the clinical laboratory staff’s unfamiliarity with the study protocol. Some participants indicated a preference for more elements of the study protocol (e.g., transporting collection materials) to be left to the responsibility of the research team. Future studies should carefully consider the delegation of responsibility between participants and the research team to balance both study reach and participant accessibility. Alternative formats, such as at-home collection or collaboration with community health workers, may further enhance participant satisfaction and convenience.
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- 2024
4. Deploying Purposeful Scholarship to Accelerate Academic Achievement
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Flowers, Tiffany A. and Flowers, Lamont A.
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- 2024
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5. 719-P: Metabolomic Characteristics Associated with Changes in Fasting Blood Glucose in a 12-Month Lifestyle Intervention Trial
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LEWIS, KIMBERLY A, STROEBEL, BENJAMIN M, ZHANG, LI, KANAYA, ALKA M, and FLOWERS, ELENA
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Medical Biochemistry and Metabolomics ,Biomedical and Clinical Sciences ,Prevention ,Health Disparities ,Minority Health ,Clinical Research ,Nutrition ,Clinical Trials and Supportive Activities ,Biotechnology ,Obesity ,Diabetes ,Metabolic and endocrine ,Medical and Health Sciences ,Endocrinology & Metabolism ,Biomedical and clinical sciences - Abstract
Introduction & Objective: Lifestyle interventions are effective type 2 diabetes (T2D) prevention strategies, yet little is known about metabolic pathways associated with intervention response in at-risk individuals. The study's purpose was to characterize the baseline metabolome in adults at risk for T2D who responded to a 12-month lifestyle intervention randomized controlled trial with significantly reduced fasting blood glucose (FBG). Methods: This study analyzed de novo untargeted primary metabolome data from 113 plasma samples stored in a biorepository. The parent study recruited participants from San Diego and San Francisco communities between 2009-2012. Data were acquired via the West Coast Metabolomics Core Laboratory using validated liquid chromatography mass spectrometry methods and 15-25 internal standards. Metabolites were quantified by peak heights. Relative concentrations were compared between lifestyle intervention responders and non-responders using independent t-tests and then adjusted for multiple comparisons. Results: Six metabolites were significantly different (unadj p
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- 2024
6. Good data relations key to Indigenous research sovereignty: A case study from Nunatsiavut
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Ortenzi, Kate M., Flowers, Veronica L., Pamak, Carla, Saunders, Michelle, Schmidt, Jörn O., and Bailey, Megan
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- 2024
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7. Geriatric Facial Dermatosis
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Flowers, R. Hal, Im, Grace Y., Jowdy, Peter, Cohen, Olivia G., Lanyi, Shira, and Omesiete, Wilson
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- 2024
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8. Fragmentation in One Health policy and practice responses to antimicrobial resistance and the salutary value of collaborative humility
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Davis, Mark David McGregor, Schermuly, Allegra Clare, Rajkhowa, Arjun, Flowers, Paul, Hardefeldt, Laura, and Thursky, Karin
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- 2024
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9. Validation of the Forms of Bullying Scale-Perpetration (FBS-P) in the United States
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Flowers, Jaime, Dawes, Jillian, Marr, Dallin, and Cuitareo, Jessica
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- 2024
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10. Cardiovascular events reported in patients with B-cell malignancies treated with zanubrutinib.
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Moslehi, Javid, Furman, Richard, Tam, Constantine, Salem, Joe-Elie, Flowers, Christopher, Cohen, Aileen, Zhang, Meng, Zhang, Jun, Chen, Lipeng, Ma, Han, and Brown, Jennifer
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Humans ,Pyrimidines ,Pyrazoles ,Piperidines ,Male ,Aged ,Female ,Protein Kinase Inhibitors ,Middle Aged ,Cardiovascular Diseases ,Adenine ,Agammaglobulinaemia Tyrosine Kinase ,Incidence ,Atrial Fibrillation ,Aged ,80 and over - Abstract
First-generation Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has been associated with an increased risk of cardiovascular toxicities. Zanubrutinib is a more selective, next-generation BTK inhibitor. In this analysis, incidence rates of atrial fibrillation, symptomatic (grade ≥2) ventricular arrhythmia, and hypertension were evaluated in a pooled analysis of 10 clinical studies with zanubrutinib monotherapy in patients (N = 1550) with B-cell malignancies and a pooled analysis of head-to-head studies comparing zanubrutinib with ibrutinib (ASPEN cohort 1; ALPINE). Among the 10 studies, most patients (median age, 67 years) were male (66.3%) and had CLL/SLL (60.5%). Overall incidence and exposure-adjusted incidence rates (EAIR) for atrial fibrillation, symptomatic ventricular arrhythmia, and hypertension were lower with zanubrutinib than ibrutinib. Despite a similar prevalence of preexisting cardiovascular events in ASPEN and ALPINE, atrial fibrillation/flutter incidence rates (6.1% vs 15.6%) and EAIR (0.2 vs 0.64 persons per 100 person-months; P < .0001) were lower with zanubrutinib than with ibrutinib. Symptomatic ventricular arrhythmia incidence was low for both zanubrutinib (0.7%) and ibrutinib (1.7%) with numerically lower EAIR (0.02 vs 0.06 persons per 100 person-months, respectively) for zanubrutinib. The hypertension EAIR was lower with zanubrutinib than ibrutinib in ASPEN but similar between treatment arms in ALPINE. The higher hypertension EAIR in ALPINE was inconsistent with other zanubrutinib studies. However, fewer discontinuations (1 vs 14) and deaths (0 vs 6) due to cardiac disorders occurred with zanubrutinib versus ibrutinib in ALPINE. These data support zanubrutinib as a treatment option with improved cardiovascular tolerability compared with ibrutinib for patients with B-cell malignancies in need of BTK inhibitors. These trials were registered at www.ClinicalTrials.gov as # NCT03053440, NCT03336333, NCT03734016, NCT04170283, NCT03206918, NCT03206970, NCT03332173, NCT03846427, NCT02343120, and NCT03189524.
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- 2024
11. Abstract P114: Micro RNAs Associated With Clinical Classifiers of Gender, Race and Ethnicity in the Diabetes Prevention Program
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Stroebel, Benjamin M, Zhang, Li, Aouizerat, Bradley E, Lewis, Kimberly A, Longoria, Kayla D, Gadgil, Meghana, and Flowers, Elena
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Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Cardiovascular ,Genetics ,Diabetes ,Obesity ,Biotechnology ,Clinical Research ,Prevention ,Nutrition ,Metabolic and endocrine ,Good Health and Well Being ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Sports science and exercise - Abstract
Introduction: Metabolic syndrome (MetS) is a prominent risk factor for both cardiovascular disease (CVD) and type 2 diabetes (T2D). MicroRNAs (miRs) are small noncoding RNA molecules that target messenger RNAs to alter gene expression. Circulating miRs have been studied as potential clinically meaningful biomarkers of risk for MetS as they are readily measured from blood. Though associations among MetS components and social constructs of race, ethnicity, and gender have previously been established, grouping according to these constructs alone may conflate genetic ancestry with the environmental/behavioral effects of being characterized as a particular gender, race, or ethnicity. The purpose of this study was to identify differences in circulating miRs associated with demographic factors and MetS components to better illuminate the nuanced health impacts of race, ethnicity and gender. Methods: This was a secondary analysis of a subset of participants (N=1000) from the Diabetes Prevention Program (DPP). A custom Fireplex assay was used to quantify miRs from banked plasma collected at baseline. Correlations between miRs and metabolic syndrome components were assessed by Pearson’s correlation coefficient. Multivariable linear models adjusted for age and weight were used to analyze associations between gender, race, ethnicity, and miR expression. The Benjamini-Hochberg false discovery rate (FDR) method was applied. Results: The sample was 68% female, 19% Black, 15% Hispanic, and mean age was 52 ± 10 years. After adjusting for multiple comparisons (FDR
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- 2024
12. Centering Equity in the Implementation of Exposure and Response Prevention for Pediatric OCD: Current Evidence and Future Directions
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Rudrabhatla, Asha, Flowers, Sasha, Becker-Haimes, Emily M., and Sanchez, Amanda L.
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- 2024
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13. Here Is the Biology, Now What Is the Mechanism? Investigating Biology Undergraduates' Mechanistic Reasoning within the Context of Biofilm Development
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Flowers, Sharleen, Holder, Kal H., and Gardnera, Stephanie M.
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Understanding molecular processes and coordinating the various activities across levels of organization in biological systems is a complicated task, yet many curricular guidelines indicate that undergraduate students should master it. Employing mechanistic reasoning can facilitate describing and investigating biological phenomena. Biofilms are an important system in microbiology and biology education. However, few empirical studies have been conducted on student learning of biofilms or how students utilize mechanistic reasoning related to systems thinking to explain biofilm formation. Using mechanistic reasoning and the theory of knowledge integration as conceptual and analytical frameworks, we examined the features of 9 undergraduate biology students' mechanistic models of a specific transition point in biofilm development. From these data, we constructed a model of knowledge integration in the context of biofilms, which categorizes students' knowledge based on features of their descriptions (e.g., entities, correct connections, and the nature of connections). We found that 4 of 9 students produced a fragmented model, 4 of 9 students produced a transitional model, and 1 student produced a connected model. Overall, students often did not discuss cell-cell communication mechanics in their mechanistic models and rarely included the role of gene regulation. Most connections were considered nonnormative and lacked important entities, leading to an abundance of unspecified causal connections. We recommend increasing instructional support of mechanistic reasoning within systems (e.g., identifying entities across levels of organization and their relevant activities) and creating opportunities for students to grapple with their understanding of various biological concepts and to explore how processes interact and connect in a complex system.
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- 2023
14. The Spanish Version of the Sussex-Oxford Compassion for Others Scale (SOCS–O) in Nursing Students: Psychometric Properties and Its Relation with Mindfulness
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Sansó, Noemí, Escrivá-Martínez, Tamara, Flowers, Sarah, West, Michael A., and Galiana, Laura
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- 2024
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15. Directed conservation of the world’s reef sharks and rays
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Goetze, Jordan S., Heithaus, Michael R., MacNeil, M. Aaron, Harvey, Euan, Simpfendorfer, Colin A., Heupel, Michelle R., Meekan, Mark, Wilson, Shaun, Bond, Mark E., Speed, Conrad W., Currey-Randall, Leanne M., Fisher, Rebecca, Sherman, C. Samantha, Kiszka, Jeremy J., Rees, Matthew J., Udyawer, Vinay, Flowers, Kathryn I., Clementi, Gina M., Asher, Jacob, Beaufort, Océane, Bernard, Anthony T. F., Berumen, Michael L., Bierwagen, Stacy L., Boslogo, Tracey, Brooks, Edward J., Brown, J. Jed, Buddo, Dayne, Cáceres, Camila, Casareto, Sara, Charloo, Venkatesh, Cinner, Joshua E., Clua, Eric E. G., Cochran, Jesse E. M., Cook, Neil, D’Alberto, Brooke M., de Graaf, Martin, Dornhege-Lazaroff, Mareike C., Fanovich, Lanya, Farabaugh, Naomi F., Fernando, Daniel, Ferreira, Carlos Eduardo Leite, Fields, Candace Y. A., Flam, Anna L., Floros, Camilla, Fourqurean, Virginia, Barcia, Laura García, Garla, Ricardo, Gastrich, Kirk, George, Lachlan, Graham, Rory, Hagan, Valerie, Hardenstine, Royale S., Heck, Stephen M., Heithaus, Patricia, Henderson, Aaron C., Hertler, Heidi, Hueter, Robert E., Johnson, Mohini, Jupiter, Stacy D., Kaimuddin, Muslimin, Kasana, Devanshi, Kelley, Megan, Kessel, Steven T., Kiilu, Benedict, Kyne, Fabian, Langlois, Tim, Lawe, Jaedon, Lédée, Elodie J. I., Lindfield, Steve, Maggs, Jade Q., Manjaji-Matsumoto, B. Mabel, Marshall, Andrea, Matich, Philip, McCombs, Erin, McLean, Dianne, Meggs, Llewelyn, Moore, Stephen, Mukherji, Sushmita, Murray, Ryan, Newman, Stephen J., O’Shea, Owen R., Osuka, Kennedy E., Papastamatiou, Yannis P., Perera, Nishan, Peterson, Bradley J., Pina-Amargós, Fabián, Ponzo, Alessandro, Prasetyo, Andhika, Quamar, L. M. Sjamsul, Quinlan, Jessica R., Razafindrakoto, Christelle F., Rolim, Fernanda A., Ruiz-Abierno, Alexei, Ruiz, Hector, Samoilys, Melita A., Sala, Enric, Sample, William R., Schärer-Umpierre, Michelle, Schoen, Sara N., Schlaff, Audrey M., Smith, Adam N. H., Sparks, Lauren, Stoffers, Twan, Tanna, Akshay, Torres, Rubén, Travers, Michael J., Valentin-Albanese, Jasmine, Warren, Joseph D., Watts, Alexandra M., Wen, Colin K., Whitman, Elizabeth R., Wirsing, Aaron J., Zarza-González, Esteban, and Chapman, Demian D.
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- 2024
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16. Efficacy and safety of a four-drug, quarter-dose treatment for hypertension: the QUARTET USA randomized trial
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Huffman, Mark D., Baldridge, Abigail S., Lazar, Danielle, Abbas, Hiba, Mejia, Jairo, Flowers, Fallon M., Quintana, Adriana, Jackson, Alema, Kandula, Namratha R., Lloyd-Jones, Donald M., Persell, Stephen D., Khan, Sadiya S., Paparello, James J., Chopra, Aashima, Tripathi, Priya, Vu, My H., Chow, Clara K., and Ciolino, Jody D.
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- 2024
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17. Multivariate brain-cognition associations in euthymic bipolar disorder
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Little, Bethany, Flowers, Carly, Blamire, Andrew, Thelwall, Peter, Taylor, John-Paul, Gallagher, Peter, Cousins, David Andrew, and Wang, Yujiang
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Quantitative Biology - Neurons and Cognition - Abstract
Background: People with bipolar disorder (BD) tend to show widespread cognitive impairment compared to healthy controls. Impairments in processing speed (PS), attention, and executive function (EF) may represent 'core' impairments that have a role in wider cognitive dysfunction. Cognitive impairments appear to relate to structural brain abnormalities in BD, but whether core deficits are related to particular brain regions is unclear and much of the research on brain-cognition associations is limited by univariate analysis and small samples. Methods: Euthymic BD patients (n=56) and matched healthy controls (n=26) underwent T1-weighted MRI scans and completed neuropsychological tests of PS, attention, and EF. We utilised public datasets to develop a normative model of cortical thickness (n=5,977) to generate robust estimations of cortical abnormalities in patients. Canonical correlation analysis was used to assess multivariate brain-cognition associations in BD, controlling for age, sex, and premorbid IQ. Results: BD showed impairments on tests of PS, attention, and EF, and abnormal cortical thickness in several brain regions compared to healthy controls. Impairments in tests of PS and EF were most strongly associated with cortical thickness in left inferior temporal, right entorhinal, and right temporal pole areas. Conclusion: Impairments in PS, attention, and EF can be observed in euthymic BD and may be related to abnormal cortical thickness in temporal regions. Future research should continue to leverage multivariate methods to examine complex brain-cognition associations in BD. Future research may benefit from exploring covariance between traditional brain structural morphological metrics such as cortical thickness, cortical volume, and surface area.
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- 2023
18. DBsurf: A Discrepancy Based Method for Discrete Stochastic Gradient Estimation
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Arabi, Pau Mulet, Flowers, Alec, Mauch, Lukas, and Cardinaux, Fabien
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Computer Science - Machine Learning ,I.2.0 - Abstract
Computing gradients of an expectation with respect to the distributional parameters of a discrete distribution is a problem arising in many fields of science and engineering. Typically, this problem is tackled using Reinforce, which frames the problem of gradient estimation as a Monte Carlo simulation. Unfortunately, the Reinforce estimator is especially sensitive to discrepancies between the true probability distribution and the drawn samples, a common issue in low sampling regimes that results in inaccurate gradient estimates. In this paper, we introduce DBsurf, a reinforce-based estimator for discrete distributions that uses a novel sampling procedure to reduce the discrepancy between the samples and the actual distribution. To assess the performance of our estimator, we subject it to a diverse set of tasks. Among existing estimators, DBsurf attains the lowest variance in a least squares problem commonly used in the literature for benchmarking. Furthermore, DBsurf achieves the best results for training variational auto-encoders (VAE) across different datasets and sampling setups. Finally, we apply DBsurf to build a simple and efficient Neural Architecture Search (NAS) algorithm with state-of-the-art performance., Comment: 22 pages, 7 figures
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- 2023
19. MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program
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Lewis, Kimberly A, Stroebel, Benjamin M, Zhang, Li, Aouizerat, Bradley, Mattis, Aras N, and Flowers, Elena
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Medicinal and Biomolecular Chemistry ,Chemical Sciences ,Clinical Trials and Supportive Activities ,Nutrition ,Obesity ,Biotechnology ,Clinical Research ,Prevention ,Diabetes ,Metabolic and endocrine ,Good Health and Well Being ,Metformin ,Humans ,Female ,Diabetes Mellitus ,Type 2 ,Middle Aged ,Male ,MicroRNAs ,Hypoglycemic Agents ,Adult ,Biomarkers ,Prediabetic State ,diabetes risk ,diabetes prevention program ,microRNA ,metformin ,post-transcription ,Other Chemical Sciences ,Genetics ,Other Biological Sciences ,Chemical Physics ,Biochemistry and cell biology ,Microbiology ,Medicinal and biomolecular chemistry - Abstract
The Diabetes Prevention Program (DPP) randomized controlled trial demonstrated that metformin treatment reduced progression to type 2 diabetes (T2D) by 31% compared to placebo in adults with prediabetes. Circulating micro-ribonucleic acids (miRs) are promising biomarkers of T2D risk, but little is known about their associations with metformin regimens for T2D risk reduction. We compared the change in 24 circulating miRs from baseline to 2 years in a subset from DPP metformin intervention (n = 50) and placebo (n = 50) groups using Wilcoxon signed rank tests. Spearman correlations were used to evaluate associations between miR change and baseline clinical characteristics. Multiple linear regression was used to adjust for covariates. The sample was 73% female, 17% Black, 13% Hispanic, and 50 ± 11 years. Participants were obese, normotensive, prediabetic, and dyslipidemic. Change in 12 miR levels from baseline to 2 years was significantly different in the metformin group compared with placebo after adjusting for multiple comparisons: six (let-7c-5p, miR-151a-3p, miR-17-5p, miR-20b-5p, miR-29b-3p, and miR-93-5p) were significantly upregulated and six (miR-130b-3p, miR-22-3p, miR-222-3p, miR-320a-3p, miR-320c, miR-92a-3p) were significantly downregulated in the metformin group. These miRs help to explain how metformin is linked to T2D risk reduction, which may lead to novel biomarkers, therapeutics, and precision health strategies.
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- 2024
20. Automated multiconformer model building for X-ray crystallography and cryo-EM
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Wankowicz, Stephanie A, Ravikumar, Ashraya, Sharma, Shivani, Riley, Blake, Raju, Akshay, Hogan, Daniel W, Flowers, Jessica, van den Bedem, Henry, Keedy, Daniel A, and Fraser, James S
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Biochemistry and Cell Biology ,Biological Sciences ,Bioengineering ,Networking and Information Technology R&D (NITRD) ,1.1 Normal biological development and functioning ,1.4 Methodologies and measurements ,Generic health relevance ,Cryoelectron Microscopy ,Crystallography ,X-Ray ,Models ,Molecular ,Protein Conformation ,Proteins ,Software ,Algorithms ,Computational Biology ,structural biology ,conformational heterogeneity ,cryo-EM ,protein dynamics ,X-ray crystallography ,None ,molecular biophysics ,none ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce density maps that are ensemble averages, reflecting molecules in various conformations. Yet, most models derived from these maps explicitly represent only a single conformation, overlooking the complexity of biomolecular structures. To accurately reflect the diversity of biomolecular forms, there is a pressing need to shift toward modeling structural ensembles that mirror the experimental data. However, the challenge of distinguishing signal from noise complicates manual efforts to create these models. In response, we introduce the latest enhancements to qFit, an automated computational strategy designed to incorporate protein conformational heterogeneity into models built into density maps. These algorithmic improvements in qFit are substantiated by superior Rfree and geometry metrics across a wide range of proteins. Importantly, unlike more complex multicopy ensemble models, the multiconformer models produced by qFit can be manually modified in most major model building software (e.g., Coot) and fit can be further improved by refinement using standard pipelines (e.g., Phenix, Refmac, Buster). By reducing the barrier of creating multiconformer models, qFit can foster the development of new hypotheses about the relationship between macromolecular conformational dynamics and function.
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- 2024
21. Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimers disease (BenfoTeam).
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Luchsinger, José, Léger, Gabriel, Taylor, Curtis, Jacobs, Diane, Salmon, David, Edland, Steven, Messer, Karen, Revta, Carolyn, Flowers, Sarah, Jones, Kerry, Koulman, Albert, Yarasheski, Kevin, Verghese, Philip, Venkatesh, Venky, Zetterberg, Henrik, Durant, January, Lupo, Jody-Lynn, Gibson, Gary, and Feldman, Howard
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Humans ,Alzheimer Disease ,Thiamine ,Double-Blind Method ,Male ,Female ,Aged ,Middle Aged ,Treatment Outcome ,Prodrugs - Abstract
BACKGROUND: Benfotiamine provides an important novel therapeutic direction in Alzheimers disease (AD) with possible additive or synergistic effects to amyloid targeting therapeutic approaches. OBJECTIVE: To conduct a seamless phase 2A-2B proof of concept trial investigating tolerability, safety, and efficacy of benfotiamine, a prodrug of thiamine, as a first-in-class small molecule oral treatment for early AD. METHODS: This is the protocol for a randomized, double-blind, placebo-controlled 72-week clinical trial of benfotiamine in 406 participants with early AD. Phase 2A determines the highest safe and well-tolerated dose of benfotiamine to be carried forward to phase 2B. During phase 2A, real-time monitoring of pre-defined safety stopping criteria in the first approximately 150 enrollees will help determine which dose (600 mg or 1200 mg) will be carried forward into phase 2B. The phase 2A primary analysis will test whether the rate of tolerability events (TEs) is unacceptably high in the high-dose arm compared to placebo. The primary safety endpoint in phase 2A is the rate of TEs compared between active and placebo arms, at each dose. The completion of phase 2A will seamlessly transition to phase 2B without pausing or stopping the trial. Phase 2B will assess efficacy and longer-term safety of benfotiamine in a larger group of participants through 72 weeks of treatment, at the selected dose. The co-primary efficacy endpoints in phase 2B are CDR-Sum of Boxes and ADAS-Cog13. Secondary endpoints include safety and tolerability measures; pharmacokinetic measures of thiamine and its esters, erythrocyte transketolase activity as blood markers of efficacy of drug delivery; ADCS-ADL-MCI; and MoCA. CONCLUSION: The BenfoTeam trial utilizes an innovative seamless phase 2A-2B design to achieve proof of concept. It includes an adaptive dose decision rule, thus optimizing exposure to the highest and best-tolerated dose. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT06223360, registered on January 25, 2024. https://classic.clinicaltrials.gov/ct2/show/NCT06223360.
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- 2024
22. Erythema elevatum diutinum in a patient with well-controlled Crohn disease
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McKenna, Brian, Blechman, Adam, Gru, Alejandro, and Flowers, R Hal
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Crohn disease ,erythema elevatum diutinum ,inflammatory bowel ,leukocytoclastic vasculitis - Abstract
Erythema elevatum diutinum is a rare, chronic cutaneous leukocytoclastic vasculitis, with prominent fibrosis at its later stage. In this article, we report a case of erythema elevatum diutinum in a 23-year-old woman with well-controlled Crohn disease. To our knowledge, erythema elevatum diutinum has been reported in only three other cases of Crohn disease, in which eruptions of erythema elevatum diutinum were associated with features of active Crohn. Our patient was in clinical remission at the time of erythema elevatum diutinum onset, making this report significant not only for its uncommon presentation, but more importantly, to aid readers. diagnosis and clinical management of similar cases.
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- 2024
23. Measurement of differential ZZ + jets production cross sections in pp collisions at s = 13 TeV
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Escalante Del Valle, A., Hussain, P. S., Jeitler, M., Krammer, N., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Van Mechelen, P., Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., El Faham, H., Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Van Putte, S., Vannerom, D., Clerbaux, B., De Lentdecker, G., Favart, L., Hohov, D., Jaramillo, J., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Pétré, L., Postiau, N., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Rendón, C., Samalan, A., Skovpen, K., Van Den Bossche, N., Wezenbeek, L., Benecke, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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24. Observation of the Λb0→J/ψΞ-K+ decay
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Valle, A. Escalante Del, Hussain, P. S., Jeitler, M., Krammer, N., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Mechelen, P. Van, Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., El Faham, H., Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Van Putte, S., Vannerom, D., Clerbaux, B., De Lentdecker, G., Favart, L., Hohov, D., Jaramillo, J., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Pétré, L., Postiau, N., Thomas, L., Bemden, M. Vanden, Velde, C. Vander, Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Rendón, C., Samalan, A., Skovpen, K., Bossche, N. Van Den, Wezenbeek, L., Benecke, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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25. Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at s = 13 TeV
- Author
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Escalante Del Valle, A., Hussain, P. S., Jeitler, M., Krammer, N., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Van Mechelen, P., Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., El Faham, H., Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Van Putte, S., Vannerom, D., Clerbaux, B., De Lentdecker, G., Favart, L., Hohov, D., Jaramillo, J., Khalilzadeh, A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Pétré, L., Postiau, N., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Rendón, C., Samalan, A., Skovpen, K., Van Den Bossche, N., Wezenbeek, L., Benecke, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Mondal, K., Tran, T. T., Wertz, S., Alves, G. A., Coelho, E., Hensel, C., Menezes De Oliveira, T., Moraes, A., Rebello Teles, P., Soeiro, M., Aldá Júnior, W. L., Alves Gallo Pereira, M., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Martins, J., Mora Herrera, C., Mota Amarilo, K., Mundim, L., Nogima, H., Santoro, A., Silva Do Amaral, S. M., Sznajder, A., Thiel, M., Vilela Pereira, A., Bernardes, C. A., Calligaris, L., Fernandez Perez Tomei, T. R., Gregores, E. M., Mercadante, P. G., Novaes, S. F., Orzari, B., Padula, Sandra S., Aleksandrov, A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Shopova, M., Sultanov, G., Dimitrov, A., Ivanov, T., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Thakur, S., Cheng, T., Guo, Q., Javaid, T., Mittal, M., Yuan, L., Bauer, G., Hu, Z., Yi, K., Chen, G. M., Chen, H. S., Chen, M., Iemmi, F., Jiang, C. H., Kapoor, A., Liao, H., Liu, Z.-A., Monti, F., Shahzad, M. A., Sharma, R., Song, J. N., Tao, J., Wang, C., Wang, J., Wang, Z., Zhang, H., Agapitos, A., Ban, Y., Levin, A., Li, C., Li, Q., Lyu, X., Mao, Y., Qian, S. J., Sun, X., Wang, D., Yang, H., Zhang, L., Zhou, C., You, Z., Lu, N., Gao, X., Leggat, D., Okawa, H., Zhang, Y., Lin, Z., Lu, C., Xiao, M., Avila, C., Barbosa Trujillo, D. A., Cabrera, A., Florez, C., Fraga, J., Reyes Vega, J. A., Mejia Guisao, J., Ramirez, F., Rodriguez, M., Ruiz Alvarez, J. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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26. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s = 13 TeV using leptonic W boson decays
- Author
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Hussain, P. S., Jeitler, M., Krammer, N., Li, A., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Janssen, T., Van Laer, T., Van Mechelen, P., Breugelmans, N., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., Heyen, F., Lowette, S., Makarenko, I., Müller, D., Tavernier, S., Tytgat, M., Van Onsem, G. P., Van Putte, S., Vannerom, D., Bilin, B., Clerbaux, B., Das, A. K., De Lentdecker, G., Evard, H., Favart, L., Gianneios, P., Jaramillo, J., Khalilzadeh, A., Khan, F. A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Shahzad, M. A., Thomas, L., Vanden Bemden, M., Vander Velde, C., Vanlaer, P., De Coen, M., Dobur, D., Gokbulut, G., Hong, Y., Knolle, J., Lambrecht, L., Marckx, D., Mota Amarilo, K., Samalan, A., Skovpen, K., Van Den Bossche, N., van der Linden, J., Wezenbeek, L., Benecke, A., Bethani, A., Bruno, G., Caputo, C., De Favereau De Jeneret, J., Delaere, C., Donertas, I. S., Giammanco, A., Guzel, A. O., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Tran, T. T., Wertz, S., Alves, G. A., Alves Gallo Pereira, M., Coelho, E., Correia Silva, G., Hensel, C., Menezes De Oliveira, T., Mora Herrera, C., Moraes, A., Rebello Teles, P., Soeiro, M., Vilela Pereira, A., Aldá Júnior, W. L., Barroso Ferreira Filho, M., Brandao Malbouisson, H., Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., Fonseca De Souza, S., Gomes De Souza, R., Macedo, M., Martins, J., Mundim, L., Nogima, H., Pinheiro, J. P., Santoro, A., Sznajder, A., Thiel, M., Bernardes, C. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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27. Measurement of differential ZZ + jets production cross sections in pp collisions at s $$ \sqrt{s} $$ = 13 TeV
- Author
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. 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- Subjects
Hadron-Hadron Scattering ,Vector Boson Production ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Diboson production in association with jets is studied in the fully leptonic final states, pp → (Z/γ *)(Z/γ *) + jets → 2ℓ2ℓ′ + jets, (ℓ, ℓ′ = e or μ) in proton-proton collisions at a center-of-mass energy of 13 TeV. The data sample corresponds to an integrated luminosity of 138 fb −1 collected with the CMS detector at the LHC. Differential distributions and normalized differential cross sections are measured as a function of jet multiplicity, transverse momentum p T, pseudorapidity η, invariant mass and ∆η of the highest-p T and second-highest-p T jets, and as a function of invariant mass of the four-lepton system for events with various jet multiplicities. These differential cross sections are compared with theoretical predictions that mostly agree with the experimental data. However, in a few regions we observe discrepancies between the predicted and measured values. Further improvement of the predictions is required to describe the ZZ+jets production in the whole phase space.
- Published
- 2024
- Full Text
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28. Observation of the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay
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CMS Collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. 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Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, M. Sergeev, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Using proton–proton collision data corresponding to an integrated luminosity of $$140\hbox { fb}^{-1}$$ 140 fb - 1 collected by the CMS experiment at $$\sqrt{s}= 13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V , the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} $$ Λ b 0 → J / ψ Ξ - K + decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the $${{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} $$ Λ b 0 → ψ ( 2 S ) Λ decay, is measured to be $$\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{\text {J}/\uppsi }} {{{\Xi }} ^{{-}}} {{\text {K}} ^{{+}}} )/\mathcal {B}({{{\Lambda }} _{\text {b}}^{{0}}} \rightarrow {{{\uppsi }} ({2\textrm{S}})} {{\Lambda }} ) = [3.38\pm 1.02\pm 0.61\pm 0.03]\%$$ B ( Λ b 0 → J / ψ Ξ - K + ) / B ( Λ b 0 → ψ ( 2 S ) Λ ) = [ 3.38 ± 1.02 ± 0.61 ± 0.03 ] % , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in $$\mathcal {B}({{{\uppsi }} ({2\textrm{S}})} \rightarrow {{\text {J}/\uppsi }} {{{\uppi }} ^{{+}}} {{{\uppi }} ^{{-}}} )$$ B ( ψ ( 2 S ) → J / ψ π + π - ) and $$\mathcal {B}({{{\Xi }} ^{{-}}} \rightarrow {{\Lambda }} {{{\uppi }} ^{{-}}} )$$ B ( Ξ - → Λ π - ) .
- Published
- 2024
- Full Text
- View/download PDF
29. A Randomized Controlled Trial Comparing STREAMLINE Canaloplasty to Trabecular Micro-Bypass Stent Implantation in Primary Open-Angle Glaucoma
- Author
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Goldberg DF, Orlich C, Flowers BE, Singh IP, Tyson S, Seibold LK, ElMallah MK, Ison EM, Harbin M, Reynolds H, and Kahook MY
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primary open-angle glaucoma ,poag ,streamline ,istent inject w ,canaloplasty ,microinvasive glaucoma surgery ,migs ,Ophthalmology ,RE1-994 - Abstract
Damien F Goldberg,1 Claudio Orlich,2 Brian E Flowers,3 Inder P Singh,4 Sydney Tyson,5 Leonard K Seibold,6 Mohammed K ElMallah,7 Elysia M Ison,8 Med Harbin,8 Heather Reynolds,8 Malik Y Kahook9 1Wolstan & Goldberg Eye Associates, Torrance, CA, USA; 2Clinica 20/20, San Jose, Costa Rica; 3Ophthalmology Associates, Fort Worth, TX, USA; 4The Eye Centers of Racine & Kenosha, Racine, WI, USA; 5Eye Associates & SurgiCenter of Vineland, Vineland, NJ, USA; 6Department of Ophthalmology, University of Colorado Eye Center, Aurora, Colorado, USA; 7Ocala Eye, Ocala, FL, USA; 8New World Medical, Rancho Cucamonga, CA, USA; 9Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USACorrespondence: Malik Y Kahook, Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA, Tel +1 720 848 2501, Email Malik.Kahook@cuanschutz.eduPurpose: To report interim results of the VENICE study, a multi-center, randomized, controlled trial (RCT) comparing STREAMLINE Surgical System (STREAMLINE) canaloplasty with iStent inject W (iStent W) implantation in patients with mild-to-moderate primary open-angle glaucoma (POAG) undergoing phacoemulsification.Patients and Methods: Safety and efficacy analyses involving the first 72 randomized eyes are included in this report. Following pre- (Screening) and post-medication washout (Eligibility) visits, one eye per subject was randomized 1:1 to STREAMLINE or iStent W after undergoing uncomplicated phacoemulsification. Subjects were evaluated postoperatively at Day 1, Week 1, Month 1, 3, and 6. Intraocular pressure (IOP) measurements, number of IOP-lowering medications, and adverse events (AEs) were assessed at each follow-up visit.Results: Seventy-two eyes were randomized; 35 underwent STREAMLINE canaloplasty and 37 were implanted with the iStent W. Seventy eyes completed their 6-month follow-up. Both the mean morning post-washout Baseline IOP between STREAMLINE 24.86± 3.05 mmHg and iStent W 25.16± 3.41 mmHg and the mean IOP at 6 months between STREAMLINE eyes 16.52± 3.63 mmHg and iStent W eyes 16.08± 3.19 mmHg were not statistically significantly different (p=0.691 and 0.596, respectively). At 6 months, more eyes were on zero glaucoma medications in the STREAMLINE group (81.8%) compared to the iStent W group (78.4%). In medication-free eyes, the mean IOP was reduced from 24.80± 2.79 mmHg to 16.00± 3.40 mmHg and 24.60± 3.18 mmHg to 15.80± 2.21 mmHg in the STREAMLINE and iStent W groups, respectively (p=0.752). Both groups showed reduction in IOP-lowering medications at every visit, compared to pre-washout (Screening), with STREAMLINE resulting in numerically fewer medications 0.20± 0.48 compared to iStent W 0.40± 0.79 at 6 months (P=0.384). AEs were mild and self-limited.Conclusion: To our knowledge, the VENICE trial is the first RCT involving canaloplasty. These interim findings demonstrated comparable IOP and medication reduction between STREAMLINE canaloplasty and iStent W implantation, when combined with phacoemulsification.Keywords: primary open-angle glaucoma, POAG, STREAMLINE, iStent inject W, canaloplasty, microinvasive glaucoma surgery, MIGS
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- 2024
30. Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, P. Van Mechelen, E. S. Bols, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A. R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. 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- Subjects
Hadron-Hadron Scattering ,Higgs Physics ,Vector Boson Production ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb −1. Both hadronic and leptonic decays of V bosons are used. The leptons considered are electrons, muons, and neutrinos. The HH production is searched for in the b b ¯ b b ¯ $$ \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}} $$ decay channel. An observed (expected) upper limit at 95% confidence level of VHH production cross section is set at 294 (124) times the standard model prediction. Constraints are also set on the modifiers of the Higgs boson trilinear self-coupling, k λ , assuming k 2V = 1, and vice versa on the coupling of two Higgs bosons with two vector bosons, k 2V. The observed (expected) 95% confidence intervals of these coupling modifiers are −37.7 < k λ < 37.2 (−30.1 < k λ < 28.9) and −12.2 < k 2V < 13.5 (−7.2 < k 2V < 8.9), respectively.
- Published
- 2024
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31. Expert panel curation of 31 genes in relation to limb girdle muscular dystrophy
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Shruthi Mohan, Shannon McNulty, Courtney Thaxton, Marwa Elnagheeb, Emma Owens, May Flowers, Teagan Nunnery, Autumn Self, Brooke Palus, Svetlana Gorokhova, April Kennedy, Zhiyv Niu, Mridul Johari, Alassane Baneye Maiga, Kelly Macalalad, Amanda R. Clause, Jacques S. Beckmann, Lucas Bronicki, Sandra T. Cooper, Vijay S. Ganesh, Peter B. Kang, Akanchha Kesari, Monkol Lek, Jennifer Levy, Laura Rufibach, Marco Savarese, Melissa J. Spencer, Volker Straub, Giorgio Tasca, and Conrad C. Weihl
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective Limb girdle muscular dystrophies (LGMDs) are a group of genetically heterogeneous autosomal conditions with some degree of phenotypic homogeneity. LGMD is defined as having onset >2 years of age with progressive proximal weakness, elevated serum creatine kinase levels and dystrophic features on muscle biopsy. Advances in massively parallel sequencing have led to a surge in genes linked to LGMD. Methods The ClinGen Muscular Dystrophies and Myopathies gene curation expert panel (MDM GCEP, formerly Limb Girdle Muscular Dystrophy GCEP) convened to evaluate the strength of evidence supporting gene–disease relationships (GDR) using the ClinGen gene–disease clinical validity framework to evaluate 31 genes implicated in LGMD. Results The GDR was exclusively LGMD for 17 genes, whereas an additional 14 genes were related to a broader phenotype encompassing congenital weakness. Four genes (CAPN3, COL6A1, COL6A2, and COL6A3) were split into two separate disease entities, based on each displaying both dominant and recessive inheritance patterns, resulting in curation of 35 GDRs. Of these, 30 (86%) were classified as definitive, 4 (11%) as moderate, and 1 (3%) as limited. Two genes, POMGNT1 and DAG1, though definitively related to myopathy, currently have insufficient evidence to support a relationship specifically with LGMD. Interpretation The expert‐reviewed assertions on the clinical validity of genes implicated in LGMDs form an invaluable resource for clinicians and molecular geneticists. We encourage the global neuromuscular community to publish case‐level data that help clarify disputed or novel LGMD associations.
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- 2024
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32. Search for a resonance decaying to a W boson and a photon in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV using leptonic W boson decays
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The CMS collaboration, A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P. S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D’Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G. P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A. K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F. A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M. A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I. S. Donertas, A. Giammanco, A. O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T. T. Tran, S. Wertz, G. A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W. L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J. P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P. G. Mercadante, S. F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, D. Laroze, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J. N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S. J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Y. Li, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A. A. Ruales Barbosa, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B. K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, A. 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Bandyopadhyay, L. Hay, H. w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K. W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L. S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B. L. Winer, B. R. Yates, H. Bouchamaoui, P. Das, G. 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Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. 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Beyond Standard Model ,Hadron-Hadron Scattering ,Particle and Resonance Production ,Photon Production ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A search for a new charged particle X with mass between 0.3 and 2.0 TeV decaying to a W boson and a photon is presented, using proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment and corresponding to an integrated luminosity of 138 fb −1. Particle X has electric charge ±1 and is assumed to have spin 0. The search is performed using the electron and muon decays of the W boson. No significant excess above the predicted background is observed. The upper limit at 95% confidence level on the product of the production cross section of the X and its branching fraction to a W boson and a photon is found to be 94 (137) fb for a 0.3 TeV resonance and 0.75 (0.81) fb for a 2.0 TeV resonance, for an X width-to-mass ratio of 0.01% (5%). This search presents the most stringent constraints to date on the existence of such resonances across the probed mass range. A statistical combination with an earlier study based on the hadronic decay mode of the W boson is also performed, and the upper limit at 95% confidence level for a 2.0 TeV resonance is reduced to 0.50 (0.63) fb for an X width-to-mass ratio of 0.01% (5%).
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- 2024
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33. Peer-led intervention for individuals with major depression: study protocol for a randomized controlled trial (SUPEERMood)
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Xandra Gonzalez-Garcia, M. Lucia Moreno-Sancho, Patricia Roa-Díez, Yolanda Caceres-Tejeiro, Sarah-Louise Auvergne Flowers, Concha Gómez de Montes, Miquel Bennasar-Veny, Mauro García-Toro, and Aina M. Yañez
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Peer support ,Peer-leader ,Depression ,Major depression disorder ,Depressive disorders ,Mental health ,Psychiatry ,RC435-571 - Abstract
Abstract Background Major Depressive Disorder (MDD) is one of the most disabling mental health problems worldwide. The Recovery Model emphasizes peer support to empower individuals with MDD, improve self-management, and patients' quality of life. Despite the demonstrated efficacy of peer-led interventions, further research is needed due to methodological limitations and variability in interventions across studies. Therefore, the objective of this trial is to evaluate the effectiveness of an adjuvant peer-led intervention for the reduction of depressive symptoms in individuals diagnosed with MDD attended in primary care mental health units. Methods A controlled, parallel, randomized clinical trial will be conducted. The intervention group (n = 35) will receive 6 weeks of peer-led sessions based on a peer support program drive whilst supervised by nurses, while the control group (n = 35) will use a mobile Health (mHealth) application for emotional wellness based on CBT for 6 weeks. Measurements will be collected at baseline, at 6 weeks, at 6 and 12 months after the intervention to evaluate post-intervention effects. The primary outcome is the reduction of depressive symptoms through the Beck Depression Inventory (BDI-II) after the intervention. Secondary outcomes will involve measures such as adherence to psychiatric treatment, quality of life, adherence to mediterranean diet, alcohol consumption and physical activity. Discussion We hypothesize that this peer-led intervention, in contrast to the mHealth, will show improvement in BDI-II score reduction of 6 points after six weeks, 6 and 12 months. Standardized peer-led programs can benefit patients and professionals in terms of efficacy and feasibility of clinical treatment of depression, healthy habits, self-care and quality of life. In addition, they can provide recovery and relapse reduction, improved psychosocial support, minimization of intensive care use, and support for patient autonomy through self-management. Trial registration The trial protocol is prospectively registered with ClinicalTrials.gov under protocol registration number NCT06398561. Date of registration: May 01, 2024. Recruitment is ongoing.
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- 2024
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34. The Teacher Listening Orientation Questionnaire: A Validity Study
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Cindy M. Gilson, Claudia Flowers, and Wen-Hsuan Chang
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Effective teacher listening is critical in establishing a culturally responsive and equitable learning environment for all students. Teacher listening orientations are ways in which teachers are situated to listen to students. Measurements of their orientations during classroom discourse is an important yet under-researched tool for enhancing both communication and student learning. The extant literature suggests teachers exhibit varied listening orientations, however, limited empirical studies have investigated how teachers self-report their listening during instructional discourse within the classroom setting. In this study we redeveloped and administered a 32-item instrument called the Teacher Listening Orientation Questionnaire (TLOQ) to 536 teachers. Confirmatory factor analyses (CFAs) were conducted to test the fit of three-, four-, and six-factor oblique models. Results suggested the three-factor model best accounts for the item covariation for the TLOQ, with the factors of "evaluative," "interpretive," and "participatory/facilitative student-oriented listening." Implications for future research and professional learning are discussed.
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- 2024
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35. A New Paradigm for Sport Education Programs: An Equity-Minded and Anti-Ism Framework
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Joseph N. Cooper, Ajhanai C. I. Keaton, Marta N. Mack, Rasheed Flowers, and Joseph L. Herman II
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The purpose of this manuscript is to examine the implications of the current ideological underpinnings of sport education programs (SEPs) in the United States (U.S.) and present a new equity-minded and anti-ism sport education (EASE) framework that reflects a paradigm shift towards equity-mindedness, anti-ism, cultural responsiveness, inclusive excellence, and transformational leadership. The sport industry has transformed from modest recreational activities for leisure entertainment at the local levels into a multi-billion-dollar global corporatized industry with far-reaching economic, political and sociocultural impacts. Despite the growth in popularity of SEPs, a major area of concern is the lack of critical reflection on their sociopolitical and cultural origins of the curriculum and corresponding metrics of success. Thus, we argue current SEPs (e.g. sport management, sport administration, sport leadership, sport business, parks and recreation, and sport entertainment, hospitality, and tourism) perpetuate colorblind racism, sexism, and classism based on their philosophical foundations. In an effort to reflect a responsiveness to an increasingly global and multicultural sport industry, we present a new EASE framework for preparing professionals to ignite transformational change in and through sport in the twenty-first century.
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- 2024
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36. It's Just the Wilson Way: Investigating the Extended Impact of an Elementary Full-Service Community School Initiative on Middle School STEM-Related Outcomes
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Kathleen Provinzano, Kristin L. K. Koskey, Toni Sondergeld, and Alonzo Flowers
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This study investigated the sustained impact from elementary fullservice community school programming on middle school STEM academic outcomes that could lead to greater college and career readiness, as well as increased STEM career options for underserved urban students. Quantitative findings suggest middle school youth who attended an elementary full-service community school performed better on middle school STEM outcomes and were predicted to be more prepared to graduate and enter a STEM-related field than a matched comparison of peers who did not. Qualitative results explain differences. Two meta-inferences, informal facilitation of STEM and sustained fullservice community school impact, frame the discussion.
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- 2024
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37. Moving from the Periphery: Latinx Fathers' Influence on Their Daughters' Persistence in Engineering
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Rosa M. Banda and Alonzo Flowers
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The influential role of familía remains a crucial aspect to understand Latinxs' success in postsecondary schooling. Rather than relying on a deficit lens, this study employs an asset-based lens to gain insight into the paternal influence that assists Latinas' persistence to degree attainment in engineering. More specifically, this study examines the crucial role that fathers play in the familía as it pertains to Latina persistence in engineering programs. A conceptual framework of Community Cultural Wealth and Latinx Cultural Pedagogics undergird this case study. The themes that emerged from data analysis include (a) Fathers Living Vicariously Through Their Daughters, (b) Fathers Serving as Career Role Models and (c) Fathers Providing Unconditional Support. The authors also offer recommendations for future research.
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- 2024
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38. Review of Participatory Research Assent Procedures in School Psychology
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Jaime Flowers, Daniel McCleary, Jillian Dawes, and Hunter Marzolf
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In the realm of psychology and related fields, like school psychology, obtaining informed consent from clients or participants who are 18 years old or older is mandatory for researchers. However, if the individuals are below 18 years old or under a conservatorship, their assent is crucial even if their parent or legal guardian has provided formal consent. Despite the widespread recognition of the importance of assent during research, there is a lack of research and guidelines on how to obtain it effectively. To bridge this gap, we conducted a review and created a summary of research published in school psychology journals on gaining assent during research studies. The articles were categorized based on the experimental design, population, and level of assent described. Our findings offer a comprehensive overview of the current state of research on gaining assent in school psychology, which will enhance transparency in research methods.
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- 2024
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39. Reconciling Our Strivings: Historically Black Colleges and Universities (HBCU) in Contemporary Contexts
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Bonner, Fred A., II, Marbley, Aretha F., Flowers, Alonzo M., Burrell-Craft, Kala, Jennings, Michael E., Louis, Dave A., Goings, Ramon B., Smith, Stella L., Tilley, Stephanie D., Garcia-Powell, Barbara, Bolton, Terrance J., and Tarlton, Edward L.
- Abstract
Throughout history, Historically Black Colleges and Universities (HBCUs) have overcome countless challenges to achieve their goals of maintaining cultural traditions, providing key leadership and role models, assuring economic functions, addressing issues between minority and majority populations, and producing Black agents for research, institutional training, and information dissemination within the Black and other minority communities. Using a Scholarly Personal Narrative (SPN), this article focuses on the function, legacy, and relevance of current HBCUs. Using W. E. B. Du Bois's "double consciousness" as a theoretical framework, each of the 12 contributing scholars address these questions: How have you reconciled your individual strivings? Has the HBCU placed a role in your reconciliation process? What SPN is emblematic of your reconciliation process? These questions are addressed through vivid narrative accounts that speak to the critical constructs of belonging--Black identity; gifted education, selfhood, spirituality, and theoretical frameworks. Each of these constructs represents an identity vector that points inward to the core--the HBCU.
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- 2024
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40. 'Any Other Thoughts?': Establishing Third Space in a Family-School-University STEM Partnership to Center Voices of Parents and Teachers
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Lori A. Caudle, Margaret F. Quinn, Frances K. Harper, Hannah R. Thompson, Tabatha R. Rainwater, and Charles E. Flowers
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Research practice partnerships (RPPs) that include parents and teachers as cocreators of educational programs provide opportunities to build equitable partnerships yet require university partners to intentionally develop spaces for coconstruction and synergistic interactions. RPPs built within a third space can foster engagement of all partners in the coconstruction of knowledge and practices while assuming roles and navigating partnership work through informal and formal communication. We define a third space as a hybrid, intangible space where inter- and intracultural pedagogies are constructed and shared identity is created from historical and cultural contexts of all partners. This study explored how university partners centered teacher and parent voices in the codesign and piloting phase of a culturally relevant preschool robotics program and facilitated codevelopment within a third space. Through in-depth qualitative coding, we analyzed 6 months of early partnership exchanges to identify how we, as university partners, facilitated discourse and what roles parents and teachers assumed within our third space. Results found that university partners frequently invited participation among partners and used revoicing strategies, and parents and teachers adopted roles as educators and advisors to the program design and implementation. Implications for RPPs include considering how both facilitator-discourse moves and collaborative spaces in which parents and teachers are central to partnership conversations and decisions contribute to successful outcomes.
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- 2024
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41. Shock Synthesis of Organic Molecules by Meteoroids in the Atmosphere of Titan
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Flowers, Erin E. and Chyba, Christopher F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Thermochemical modeling and shock-tube experiments show that shocks applied to N$_2$/CH$_4$ gas mixtures can synthesize organic molecules. Sufficiently large, hypersonic meteoroids entering the atmosphere of Saturn's moon Titan should therefore drive organic chemistry. To do so meteoroids must be sufficiently large compared to the atmospheric mean free path at a given altitude to generate shocks, and deposit enough energy per path length to produce temperatures high enough to excite and dissociate the relevant molecules. The Cassini spacecraft imaged multiple meteoroid impacts on Saturn's rings, allowing for the first time an empirical estimate to be made of the flux and size-frequency distributions of meteoroids in the millimeter-to-meter size range. We combine these results with an atmospheric entry model and thermochemical and experimental shock production efficiencies for N$_2$/CH$_4$ atmospheres and calculate the shock production rates for HCN, C$_2$H$_2$, and C$_2$H$_4$ as well as the resulting H$_2$ generation. We find that meteoroids may be producing these molecules at as much as $\sim$1% the production rate of photochemistry driven by UV photons, and may be depositing more energy than magnetospheric ions and 90-100 nm UV photons. Moreover, these meteoroids produce these organic molecules hundreds of kilometers lower in Titan's atmosphere than the relevant UV photons and magnetospheric ions penetrate, with peak production occurring between 200 and 500 km altitudes, i.e., at the observed haze layer. Meteoroid-driven shock generation of molecules may therefore be crucial to understanding Titan's atmospheric chemistry., Comment: 12 pages, 6 figures
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- 2023
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42. Spatio-Temporal Avoidance of Predicted Occupancy in Human-Robot Collaboration
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Flowers, Jared, Faroni, Marco, Wiens, Gloria, and Pedrocchi, Nicola
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Computer Science - Robotics - Abstract
This paper addresses human-robot collaboration (HRC) challenges of integrating predictions of human activity to provide a proactive-n-reactive response capability for the robot. Prior works that consider current or predicted human poses as static obstacles are too nearsighted or too conservative in planning, potentially causing delayed robot paths. Alternatively, time-varying prediction of human poses would enable robot paths that avoid anticipated human poses, synchronized dynamically in time and space. Herein, a proactive path planning method, denoted STAP, is presented that uses spatiotemporal human occupancy maps to find robot trajectories that anticipate human movements, allowing robot passage without stopping. In addition, STAP anticipates delays from robot speed restrictions required by ISO/TS 15066 speed and separation monitoring (SSM). STAP also proposes a sampling-based planning algorithm based on RRT* to solve the spatio-temporal motion planning problem and find paths of minimum expected duration. Experimental results show STAP generates paths of shorter duration and greater average robot-human separation distance throughout tasks. Additionally, STAP more accurately estimates robot trajectory durations in HRC, which are useful in arriving at proactive-n-reactive robot sequencing., Comment: 7 pages, 7 figures. Accepted at IEEE ROMAN 2023
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- 2023
43. The experiences of sexual and gender minority participants with a remote biospecimen collection protocol
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Panyanouvong, Nicholas, Lella, Paavani, Sunder, Gowri, Lubensky, Micah, Dastur, Zubin, Aouizerat, Bradly, Lisah, Nadra, Neilands, Torsten, Flowers, Elena, Lunn, Mitchell, Obedin-Maliver, Juno, and Flentje, Annesa
- Abstract
Background: Sexual and gender minority (SGM) communities are underrepresented in biomedical studies, highlighting the importance of developing biospecimen collection protocols aimed at engaging SGM participants. We aimed to learn more about SGM participants’ experiences with a remote (i.e., not performed at a central location) biospecimen collection study pioneered by The PRIDE Study, a cohort study of SGM adults residing in the United States and its territories.Methods: We collected and analyzed feedback from 112 SGM participants following blood donation for a parent study investigating the relationship between minority stress, substance use, and epigenetic markers of substance use and minority stress. We used an inductive and collaborative approach to qualitative analysis and identified major themes and areas for protocol improvement.Results: Major themes among participant feedback were: (1) communication with the research team, (2) convenience of donation, (3) interactions with clinical laboratory staff, and (4) anonymity and privacy. Most participants indicated that they experienced little to no problems during the donation process and expressed approval for the clarity and transparency of the informed consent process, the ease of communication with the research team, and the measures taken to protect participant confidentiality during their appointment. The most common challenges encountered by participants related to the inconvenience of handling and transporting study materials to the clinical laboratory site and clinical laboratory staff’s unfamiliarity with the study protocol. Some participants indicated a preference for more elements of the study protocol (e.g., transporting collection materials) to be left to the responsibility of the research team.Conclusions: Our study reflects successful remote biospecimen collection among SGM participants on a national scale. Future studies should carefully consider the delegation of responsibility between participants and the research team to balance both study reach and participant accessibility. Alternative formats, such as at-home collection or collaboration with community health workers, may further enhance participant satisfaction and convenience.
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- 2023
44. The rise of New Guinea and the fall of Neogene global temperatures.
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Martin, Peter, Macdonald, Francis, McQuarrie, Nadine, Flowers, Rebecca, and Maffre, Pierre
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Miocene ,New Guinea ,ophiolites ,silicate weathering ,thermochronology - Abstract
The ~2,000-km-long Central Range of New Guinea is a hotspot of modern carbon sequestration due to the chemical weathering of igneous rocks with steep topography in the warm wet tropics. These high mountains formed in a collision between the Australian plate and ophiolite-bearing volcanic arc terranes, but poor resolution of the uplift and exhumation history has precluded assessments of the impact on global climate change. Here, we develop a palinspastic reconstruction of the Central Range orogen with existing surface geological constraints and seismic data to generate time-temperature paths and estimate volumes of eroded material. New (U-Th)/He thermochronology data reveal rapid uplift and regional denudation between 10 and 6 Mya. Erosion fluxes from the palinspastic reconstruction, calibrated for time with the thermochronological data, were used as input to a coupled global climate and weathering model. This model estimates 0.6 to 1.2 °C of cooling associated with the Late Miocene rise of New Guinea due to increased silicate weathering alone, and this CO2 sink continues to the present. Our data and modeling experiments support the hypothesis that tropical arc-continent collision and the rise of New Guinea contributed to Neogene cooling due to increased silicate weathering.
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- 2023
45. Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways.
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Flowers, Sagen, Kothari, Rushali, Torres Cleuren, Yamila, Alcorn, Melissa, Ewe, Chee, Alok, Geneva, Fiallo, Samantha, Joshi, Pradeep, and Rothman, Joel
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C. elegans ,aging ,cell biology ,genetics ,genomics ,heteroplasmy ,insulin signaling ,programmed cell death ,purifying selection ,uaDf5 ,Animals ,Caenorhabditis elegans ,DNA ,Mitochondrial ,Apoptosis ,Caspases ,Caenorhabditis elegans Proteins ,Aging - Abstract
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). Purifying selection mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell death (PCD), including the CED-3 and CSP-1 caspases, the BH3-only protein CED-13, and PCD corpse engulfment factors, are required in C. elegans to attenuate germline abundance of a 3.1-kb mtDNA deletion mutation, uaDf5, which is normally stably maintained in heteroplasmy with wildtype mtDNA. In contrast, removal of CED-4/Apaf1 or a mutation in the CED-4-interacting prodomain of CED-3, do not increase accumulation of the defective mtDNA, suggesting induction of a non-canonical germline PCD mechanism or non-apoptotic action of the CED-13/caspase axis. We also found that the abundance of germline mtDNAuaDf5 reproducibly increases with age of the mothers. This effect is transmitted to the offspring of mothers, with only partial intergenerational removal of the defective mtDNA. In mutants with elevated mtDNAuaDf5 levels, this removal is enhanced in older mothers, suggesting an age-dependent mechanism of mtDNA quality control. Indeed, we found that both steady-state and age-dependent accumulation rates of uaDf5 are markedly decreased in long-lived, and increased in short-lived, mutants. These findings reveal that regulators of both PCD and the aging program are required for germline mtDNA quality control and its intergenerational transmission.
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- 2023
46. Behavioral analytics for myopic agents
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Mintz, Yonatan, Aswani, Anil, Kaminsky, Philip, Flowers, Elena, and Fukuoka, Yoshimi
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Information and Computing Sciences ,Artificial Intelligence ,Behavioral and Social Science ,Control ,Health care ,Optimization ,Statistical inference ,Statistical Inference ,Operations Research ,Engineering ,Information and computing sciences ,Mathematical sciences - Abstract
Many multi-agent systems have a single coordinator providing incentives to a large number of agents. Two challenges faced by the coordinator are a finite budget from which to allocate incentives, and an initial lack of knowledge about the utility function of the agents. Here, we present a behavioral analytics approach for solving the coordinator's problem when the agents make decisions by maximizing utility functions that depend on prior system states, inputs, and other parameters that are initially unknown. Our behavioral analytics framework involves three steps: first, we develop a model that describes the decision-making process of an agent; second, we use data to estimate the model parameters for each agent and predict their future decisions; and third, we use these predictions to optimize a set of incentives that will be provided to each agent. The framework and approaches we propose in this paper can then adapt incentives as new information is collected. Furthermore, we prove that the incentives computed by this approach are asymptotically optimal with respect to a loss function that describes the coordinator's objective. We optimize incentives with a decomposition scheme, where each sub-problem solves the coordinator's problem for a single agent, and the master problem is a pure integer program. We conclude with a simulation study to evaluate the effectiveness of our approach for designing a personalized weight loss program. The results show that our approach maintains efficacy of the program while reducing its costs by up to 60%, while adaptive heuristics provide substantially less savings.
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- 2023
47. Author Correction: Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
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Zhang, Shaojun, Jiang, Vivian Changying, Han, Guangchun, Hao, Dapeng, Lian, Junwei, Liu, Yang, Cai, Qingsong, Zhang, Rongjia, McIntosh, Joseph, Wang, Ruiping, Dang, Minghao, Dai, Enyu, Wang, Yuanxin, Santos, David, Badillo, Maria, Leeming, Angela, Chen, Zhihong, Hartig, Kimberly, Bigcal, John, Zhou, Jia, Kanagal-Shamanna, Rashmi, Ok, Chi Young, Lee, Hun, Steiner, Raphael E., Zhang, Jianhua, Song, Xingzhi, Nair, Ranjit, Ahmed, Sairah, Rodriquez, Alma, Thirumurthi, Selvi, Jain, Preetesh, Wagner-Bartak, Nicolaus, Hill, Holly, Nomie, Krystle, Flowers, Christopher, Futreal, Andrew, Wang, Linghua, and Wang, Michael
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- 2024
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48. Peer-led intervention for individuals with major depression: study protocol for a randomized controlled trial (SUPEERMood)
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Gonzalez-Garcia, Xandra, Moreno-Sancho, M. Lucia, Roa-Díez, Patricia, Caceres-Tejeiro, Yolanda, Flowers, Sarah-Louise Auvergne, de Montes, Concha Gómez, Bennasar-Veny, Miquel, García-Toro, Mauro, and Yañez, Aina M.
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- 2024
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49. Portable Acceleration of CMS Computing Workflows with Coprocessors as a Service
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Hayrapetyan, A., Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Hussain, P. S., Jeitler, M., Krammer, N., Li, A., Liko, D., Mikulec, I., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M., Templ, S., Waltenberger, W., Wulz, C.-E., Darwish, M. R., Janssen, T., Mechelen, P. Van, Bols, E. S., D’Hondt, J., Dansana, S., De Moor, A., Delcourt, M., Faham, H. El, Lowette, S., Makarenko, I., Müller, D., Sahasransu, A. R., Tavernier, S., Tytgat, M., Onsem, G. P. Van, Putte, S. Van, Vannerom, D., Clerbaux, B., Das, A. K., De Lentdecker, G., Favart, L., Gianneios, P., Hohov, D., Jaramillo, J., Khalilzadeh, A., Khan, F. A., Lee, K., Mahdavikhorrami, M., Malara, A., Paredes, S., Thomas, L., Bemden, M. Vanden, Velde, C. Vander, Vanlaer, P., De Coen, M., Dobur, D., Hong, Y., Knolle, J., Lambrecht, L., Mestdach, G., Amarilo, K. Mota, Rendón, C., Samalan, A., Skovpen, K., Bossche, N. Van Den, Linden, J. van der, Wezenbeek, L., Benecke, A., Bethani, A., Bruno, G., Caputo, C., Delaere, C., Donertas, I. S., Giammanco, A., Jaffel, K., Jain, Sa., Lemaitre, V., Lidrych, J., Mastrapasqua, P., Mondal, K., Tran, T. T., Wertz, S., Alves, G. A., Coelho, E., Hensel, C., De Oliveira, T. Menezes, Moraes, A., Teles, P. Rebello, Soeiro, M., Júnior, W. L. Aldá, Pereira, M. Alves Gallo, Filho, M. Barroso Ferreira, Malbouisson, H. Brandao, Carvalho, W., Chinellato, J., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Souza, S. Fonseca, De Souza, R. Gomes, Martins, J., Herrera, C. Mora, Mundim, L., Nogima, H., Pinheiro, J. P., Santoro, A., Sznajder, A., Thiel, M., Pereira, A. Vilela, Bernardes, C. A., Calligaris, L., Tomei, T. R. Fernandez Perez, Gregores, E. M., Mercadante, P. G., Novaes, S. F., Orzari, B., Padula, Sandra S., Aleksandrov, A., Antchev, G., Hadjiiska, R., Iaydjiev, P., Misheva, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Thakur, S., Cheng, T., Javaid, T., Yuan, L., Hu, Z., Liu, J., Yi, K., Chen, G. M., Chen, H. S., Chen, M., Iemmi, F., Jiang, C. H., Kapoor, A., Liao, H., Liu, Z.-A., Sharma, R., Song, J. N., Tao, J., Wang, C., Wang, J., Wang, Z., Zhang, H., Agapitos, A., Ban, Y., Levin, A., Li, C., Li, Q., Mao, Y., Qian, S. J., Sun, X., Wang, D., Yang, H., Zhang, L., Zhou, C., You, Z., Lu, N., Bauer, G., Gao, X., Leggat, D., Okawa, H., Lin, Z., Lu, C., Xiao, M., Avila, C., Trujillo, D. A. Barbosa, Cabrera, A., Florez, C., Fraga, J., Vega, J. A. Reyes, Guisao, J. Mejia, Ramirez, F., Rodriguez, M., Alvarez, J. D. Ruiz, Giljanovic, D., Godinovic, N., Lelas, D., Sculac, A., Kovac, M., Sculac, T., Bargassa, P., Brigljevic, V., Chitroda, B. K., Ferencek, D., Mishra, S., Starodumov, A., Susa, T., Attikis, A., Christoforou, K., Konstantinou, S., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Saka, H., Stepennov, A., Finger, M., Finger, Jr., M., Kveton, A., Ayala, E., Jarrin, E. Carrera, Abdelalim, A. A., Salama, E., Mahmoud, M. A., Mohammed, Y., Ehataht, K., Kadastik, M., Lange, T., Nandan, S., Nielsen, C., Pata, J., Raidal, M., Tani, L., Veelken, C., Kirschenmann, H., Osterberg, K., Voutilainen, M., Bharthuar, S., Brücken, E., Garcia, F., Kallonen, K. T. S., Kinnunen, R., Lampén, T., Lassila-Perini, K., Lehti, S., Lindén, T., Martikainen, L., Myllymäki, M., Rantanen, M.m., Siikonen, H., Tuominen, E., Tuominiemi, J., Luukka, P., Petrow, H., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Gras, P., de Monchenault, G. Hamel, Lohezic, V., Malcles, J., Rander, J., Rosowsky, A., Sahin, M. Ö., Savoy-Navarro, A., Simkina, P., Titov, M., Tornago, M., Barrera, C. Baldenegro, Beaudette, F., Perraguin, A. Buchot, Busson, P., Cappati, A., Charlot, C., Chiusi, M., Damas, F., Davignon, O., De Wit, A., Alves, B. A. Fontana Santos, Ghosh, S., Gilbert, A., de Cassagnac, R. Granier, Hakimi, A., Harikrishnan, B., Kalipoliti, L., Liu, G., Motta, J., Nguyen, M., Ochando, C., Portales, L., Salerno, R., Sauvan, J. B., Sirois, Y., Tarabini, A., Vernazza, E., Zabi, A., Zghiche, A., Agram, J.-L., Andrea, J., Apparu, D., Bloch, D., Brom, J.-M., Chabert, E. C., Collard, C., Falke, S., Goerlach, U., Grimault, C., Haeberle, R., Bihan, A.-C. Le, Meena, M., Saha, G., Sessini, M. A., Hove, P. Van, Beauceron, S., Blancon, B., Boudoul, G., Chanon, N., Choi, J., Contardo, D., Depasse, P., Dozen, C., Mamouni, H. El, Fay, J., Gascon, S., Gouzevitch, M., Greenberg, C., Grenier, G., Ille, B., Laktineh, I. B., Lethuillier, M., Mirabito, L., Perries, S., Purohit, A., Donckt, M. 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S., Zarubin, A., Zhizhin, I., and Zhokin, A.
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- 2024
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50. miR-29 is an important driver of aging-related phenotypes
- Author
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Swahari, Vijay, Nakamura, Ayumi, Hollville, Emilie, Hung, Yu-Han, Kanke, Matt, Kurtz, C. Lisa, Caravia, Xurde M., Roiz-Valle, David, He, Shenghui, Krishnamurthy, Janakiraman, Kapoor, Sahil, Prasad, Varun, Flowers, Cornelius, Beck, Matt, Baran-Gale, Jeanette, Sharpless, Norman, López-Otín, Carlos, Sethupathy, Praveen, and Deshmukh, Mohanish
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- 2024
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