1. Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n− (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity
- Author
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Manuela Donalisio, Peng Yang, Bernhard K. Keppler, Tian Ma, Ulrich Kortz, Ming-Xing Li, Inga Dammann, Raluca Mitea, Ali S. Mougharbel, Zhengguo Lin, David Lembo, Klaudia Cseh, Florin Adǎscǎliţei, Roberta Cavalli, Matthias S. Ullrich, Candice A. Thorstenson, Cristian Silvestru, and Michael A. Jakupec
- Subjects
A549 cell ,Aqueous solution ,biology ,010405 organic chemistry ,Vibrio parahaemolyticus ,chemistry.chemical_element ,Pathogenic bacteria ,Vibrio vulnificus ,010402 general chemistry ,biology.organism_classification ,medicine.disease_cause ,01 natural sciences ,Medicinal chemistry ,0104 chemical sciences ,Inorganic Chemistry ,Antimony ,chemistry ,medicine ,Tetra ,Physical and Theoretical Chemistry ,Bacteria - Abstract
We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- [X = PV (1-P), AsV (1-As), or GeIV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).
- Published
- 2020
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