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2 results on '"Florian Andreas Rampf"'

1. Toward a Scalable Synthesis and Process for EMA401, Part I: Late Stage Process Development, Route Scouting, and ICH M7 Assessment

Author

Wietfeld Bernhard, Xiangguang Tian, Yong Zhang, Franck Mallet, Richard Kaehny, Cheng Li, Leo A. Hardegger, Bo Yu, Jeannine Stäuble, Lei Shi, Barbara Bianchi, Florian Andreas Rampf, Jialiang Li, Stephan Lanz, Christoph Spoendlin, Christine Zepperitz, Xuesong Zhang, Shangjun Teng, Chunlong Cai, Yao Yang, Roger Humair, and Alexandre Grand-Guillaume Perrenoud

Subjects
Process development, Chemistry, Organic Chemistry, Late stage, EMA401, Physical and Theoretical Chemistry, Combinatorial chemistry, Angiotensin II, Phenylalanine derivatives
Abstract

We present the enantioselective synthesis of sodium (3S)-5-(benzyloxy)-2-(diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (EMA401, olodanrigan), an angiotensin II type 2 anta...

Published
2020

2. Toward a Scalable Synthesis and Process for EMA401, Part III: Using an Engineered Phenylalanine Ammonia Lyase Enzyme to Synthesize a Non-natural Phenylalanine Derivative

Author

Alexandre Grand-Guillaume Perrenoud, Julien Haber, Florian Andreas Rampf, Van Tong Luu, Roger Humair, Wietfeld Bernhard, Michael Kibiger, Thomas Ruch, Lukas Padeste, Tao Hong, Pascal Beney, Yao Yang, Anikó Udvarhelyi, Leo A. Hardegger, Eric Sidler, Andreas Kaegi, Xingxian Gu, Dominique Bixel, Christian Fleury, Feng Gao, Thierry Schlama, and Florian Kleinbeck

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Process development, Chemistry, Organic Chemistry, Phenylalanine, Phenylalanine ammonia-lyase, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Part iii, chemistry.chemical_compound, Enzyme, Biocatalysis, Physical and Theoretical Chemistry, Derivative (chemistry)
Abstract

A process using an engineered phenylalanine ammonia lyase (PAL) enzyme was developed as part of an alternative route to a key intermediate of olodanrigan (EMA401). In the first part of this report,...

Published
2020

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