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1. Sociodemographic and Lifestyle Characteristics Associated with Maternal Dietary Patterns in Mexico

Author

Flores-García, M. Karen, primary, Pérez-Saldivar, María Luisa, additional, Denova-Gutiérrez, Edgar, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier A., additional, Castañeda-Echevarría, Alejandro, additional, López-Caballero, M. Guadalupe, additional, Martínez-Silva, Sofía I., additional, Rivera-González, Juan, additional, Hernández-Pineda, Norma Angélica, additional, Flores-Botello, Jesús, additional, Pérez-Gómez, Jessica Arleet, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Olvera-Durán, Jaime Ángel, additional, Martínez-Ríos, Annel, additional, García-Cortes, Luis R., additional, Almeida-Hernández, Carolina, additional, Flores-Lujano, Janet, additional, Núñez-Enriquez, Juan Carlos, additional, Mendez, Vilma Carolina Bekker, additional, Mata-Rocha, Minerva, additional, Rosas-Vargas, Haydeé, additional, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Morales, Silvia, additional, Mejía-Aranguré, Juan Manuel, additional, and López-Carrillo, Lizbeth, additional

Published
2024
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2. Implementation of a roadmap for the comprehensive diagnosis, follow-up, and research of childhood leukemias in vulnerable regions of Mexico: results from the PRONAII Strategy

Author

Núñez-Enríquez, Juan Carlos, primary, Romo-Rodríguez, Rubí, additional, Gaspar-Mendoza, Pedro, additional, Zamora-Herrera, Gabriela, additional, Torres-Pineda, Lizeth, additional, Amador-Cardoso, Jiovanni, additional, López-Blanco, Jebea A., additional, Alfaro-Hernández, Laura, additional, López-García, Lucero, additional, Rosas-Cruz, Arely, additional, Alberto-Aguilar, Dulce Rosario, additional, Trejo-Pichardo, César Omar, additional, Ramírez-Ramírez, Dalia, additional, Cruz-Maza, Astin, additional, Flores-Lujano, Janet, additional, Luna-Silva, Nuria, additional, Martínez-Martell, Angélica, additional, Martínez-Jose, Karina, additional, Ramírez-Ramírez, Anabel, additional, Solis-Poblano, Juan Carlos, additional, Zagoya-Martínez, Patricia, additional, Terán-Cerqueda, Vanessa, additional, Huerta-Moreno, Andrea, additional, Montiel-Jarquín, Álvaro, additional, Garrido-Hernández, Miguel, additional, Hernández-Ramos, Raquel, additional, Olvera-Caraza, Daniela, additional, Cruz-Medina, Cynthia Shanat, additional, Alvarez-Rodríguez, Enoch, additional, Chávez-Aguilar, Lénica Anahí, additional, Herrera-Olivares, Wilfrido, additional, García-Hidalgo, Brianda, additional, Cano-Cuapio, Lena Sarahí, additional, Guevara-Espejel, Claudia, additional, Juárez-Avendaño, Gerardo, additional, Balandrán, Juan Carlos, additional, Baños-Lara, Ma. del Rocío, additional, Cárdenas-González, Mariana, additional, Álvarez-Buylla, Elena R., additional, Pérez-Tapia, Sonia Mayra, additional, Casique-Aguirre, Diana, additional, and Pelayo, Rosana, additional

Published
2024
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3. IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia

Author

Garcia-Solorio, Joaquin, primary, Núñez-Enriquez, Juan Carlos, additional, Jiménez-Olivares, Marco, additional, Flores-Lujano, Janet, additional, Flores-Espino, Fernanda, additional, Molina-Garay, Carolina, additional, Cervera, Alejandra, additional, Casique-Aguirre, Diana, additional, Peñaloza-Gonzalez, José Gabriel, additional, Baños-Lara, Ma. Del Rocío, additional, García-Soto, Ángel, additional, Galván-Díaz, César Alejandro, additional, Olaya-Vargas, Alberto, additional, Aguilar, Hilario Flores, additional, Mata-Rocha, Minerva, additional, Garrido-Hernández, Miguel Ángel, additional, Solís-Poblano, Juan Carlos, additional, Luna-Silva, Nuria Citlalli, additional, Cano-Cuapio, Lena Sarahi, additional, Aristil-Chery, Pierre Mitchel, additional, Herrera-Quezada, Fernando, additional, Carrillo-Sanchez, Karol, additional, Muñoz-Rivas, Anallely, additional, Flores-Lagunes, Luis Leonardo, additional, Mendoza-Caamal, Elvia Cristina, additional, Villegas-Torres, Beatriz Eugenia, additional, González-Osnaya, Vincent, additional, Jiménez-Hernández, Elva, additional, Torres-Nava, José Refugio, additional, Martín-Trejo, Jorge Alfonso, additional, Gutiérrez-Rivera, María de Lourdes, additional, Espinosa-Elizondo, Rosa Martha, additional, Merino-Pasaye, Laura Elizabeth, additional, Pérez-Saldívar, María Luisa, additional, Jiménez-Morales, Silvia, additional, Curiel-Quesada, Everardo, additional, Rosas-Vargas, Haydeé, additional, Mejía-Arangure, Juan Manuel, additional, and Alaez-Verson, Carmen, additional

Published
2024
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4. Maternal and paternal ages at conception of index child and risk of childhood acute leukaemia: A multicentre case-control study in Greater Mexico City

Author

Jiménez-Hernández, Elva, Duarte-Rodríguez, David Aldebarán, Núñez-Enriquez, Juan Carlos, Flores-Lujano, Janet, Martín-Trejo, Jorge Alfonso, Espinoza-Hernández, Laura Eugenia, Arellano-Galindo, José, Medina-Sanson, Aurora, García-Jiménez, Xochiketzalli, Paredes-Aguilera, Rogelio, Flores-Villegas, Luz Victoria, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Amador-Sánchez, Raquel, Dosta-Herrera, Juan José, Mondragón-García, Javier Anastacio, Valdés-Guzmán, Heriberto, Mejía-Pérez, Laura, Espinoza-Anrubio, Gilberto, Paz-Bribiesca, María Minerva, Salcedo-Lozada, Perla, Landa-García, Rodolfo Ángel, Ramírez-Colorado, Rosario, Hernández-Mora, Luis, Pérez-Saldivar, María Luisa, Santamaría-Ascencio, Marlene, López-Loyola, Anselmo, Godoy-Esquivel, Arturo Hermilo, García-López, Luis Ramiro, Anguiano-Ávalos, Alison Ireri, Mora-Rico, Karina, Castañeda-Echevarría, Alejandro, Rodríguez-Jiménez, Roberto, Cibrian-Cruz, José Alberto, Cárdenas-Cardos, Rocío, Altamirano-García, Martha Beatriz, Sánchez-Ruiz, Martin, Rivera-Luna, Roberto, Rodríguez-Villalobos, Luis Rodolfo, Hernández-Pérez, Francisco, Olvera-Durán, Jaime Ángel, García-Cortés, Luis Rey, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Bekker-Méndez, Vilma Carolina, Jiménez-Morales, Silvia, Rosas-Vargas, Haydee, and Mejía-Aranguré, Juan Manuel

Published
2020
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5. Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry

Author

Flores-Lujano, Janet, primary, Allende-López, Aldo, additional, Duarte-Rodríguez, David Aldebarán, additional, Alarcón-Ruiz, Erika, additional, López-Carrillo, Lizbeth, additional, Shamah-Levy, Teresa, additional, Cebrián, Mariano E., additional, Baños-Lara, Ma. del Rocío, additional, Casique-Aguirre, Diana, additional, Elizarrarás-Rivas, Jesús, additional, López-Aquino, Javier Antonio, additional, Garrido-Hernández, Miguel Ángel, additional, Olvera-Caraza, Daniela, additional, Terán-Cerqueda, Vanessa, additional, Martínez-José, Karina Beatriz, additional, Aristil-Chery, Pierre Mitchel, additional, Alvarez-Rodríguez, Enoch, additional, Herrera-Olivares, Wilfrido, additional, Ruíz-Arguelles, Guillermo J., additional, Chavez-Aguilar, Lénica Anahí, additional, Márquez-Toledo, Aquilino, additional, Cano-Cuapio, Lena Sarahi, additional, Luna-Silva, Nuria Citlalli, additional, Martínez-Martell, Maria Angélica, additional, Ramirez-Ramirez, Anabel Beatriz, additional, Merino-Pasaye, Laura Elizabeth, additional, Galván-Díaz, César Alejandro, additional, Medina-Sanson, Aurora, additional, Gutiérrez-Rivera, Maria de Lourdes, additional, Martín-Trejo, Jorge Alfonso, additional, Rodriguez-Cedeño, Emmanuel, additional, Bekker-Méndez, Vilma Carolina, additional, Romero-Tlalolini, María de los Ángeles, additional, Cruz-Maza, Astin, additional, Juárez-Avendaño, Gerardo, additional, Pérez-Tapia, Sonia Mayra, additional, Rodríguez-Espinosa, Juan Carlos, additional, Suárez-Aguirre, Miriam Carmina, additional, Herrera-Quezada, Fernando, additional, Hernández-Díaz, Anahí, additional, Galván-González, Lizbeth Alondra, additional, Mata-Rocha, Minerva, additional, Olivares-Sosa, Amanda Idaric, additional, Rosas-Vargas, Haydeé, additional, Jiménez-Morales, Silvia, additional, Cárdenas-González, Mariana, additional, Álvarez-Buylla Roces, María Elena, additional, Duque-Molina, Célida, additional, Pelayo, Rosana, additional, Mejía-Aranguré, Juan Manuel, additional, and Núñez-Enriquez, Juan Carlos, additional

Published
2024
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6. Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

Author

Duarte-Rodríguez, David Aldebarán, primary, Flores-Lujano, Janet, additional, McNally, Richard J. Q., additional, Pérez-Saldivar, María Luisa, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Medina-Sanson, Aurora, additional, Paredes-Aguilera, Rogelio, additional, Merino-Pasaye, Laura Elizabeth, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier Anastacio, additional, González-Ulibarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Paz-Bribiesca, María Minerva, additional, Salcedo-Lozada, Perla, additional, Landa-García, Rodolfo Ángel, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, Santamaría-Ascencio, Marlene, additional, López-Loyola, Anselmo, additional, Godoy-Esquivel, Arturo Hermilo, additional, García-López, Luis Ramiro, additional, Anguiano-Ávalos, Alison Ireri, additional, Mora-Rico, Karina, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Jiménez, Roberto, additional, Cibrian-Cruz, José Alberto, additional, Solís-Labastida, Karina Anastacia, additional, Cárdenas-Cardos, Rocío, additional, López-Santiago, Norma, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, González-Ávila, Ana Itamar, additional, Sánchez-Ruiz, Martin, additional, Rivera-Luna, Roberto, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Hernández-Pérez, Francisco, additional, Olvera-Durán, Jaime Ángel, additional, García-Cortés, Luis Rey, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Meléndez-Zajgla, Jorge, additional, Rosas-Vargas, Haydée, additional, Vega, Elizabeth, additional, Núñez-Enríquez, Juan Carlos, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2024
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7. Association between genetic variants of membrane transporters and the risk of high-grade hematologic adverse events in a cohort of Mexican children with B-cell acute lymphoblastic leukemia

Author

Escalante-Bautista, Deyanira, primary, Cerecedo, Doris, additional, Jiménez-Hernández, Elva, additional, González-Torres, Carolina, additional, Gaytán-Cervantes, Javier, additional, Núñez-Enríquez, Juan Carlos, additional, Sepúlveda-Robles, Omar Alejandro, additional, De Ita, Marlon, additional, Jiménez-Morales, Silvia, additional, Sánchez-López, José Manuel, additional, Mata-Rocha, Minerva, additional, Torres-Nava, José Refugio, additional, Martín-Trejo, Jorge Alfonso, additional, Flores-Villegas, Luz Victoria, additional, Gutiérrez-Rivera, María de Lourdes, additional, Merino-Pasaye, Laura Elizabeth, additional, Solís-Labastida, Karina Anastacia, additional, Miranda-Madrazo, María Raquel, additional, Hernández-Echáurregui, Gabriela Alicia, additional, Orozco-Ruíz, Darío, additional, Flores-Lujano, Janet, additional, Pérez-Saldívar, María Luisa, additional, Mejía-Aranguré, Juan Manuel, additional, and Rosas-Vargas, Haydeé, additional

Published
2024
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8. Maternal diet in pregnancy and acute leukemia in infants: a case-control study in Mexico City

Author

Pérez-Saldivar, María Luisa, primary, Flores-García, M. Karen, additional, Núñez-Villegas, Nancy, additional, Fajardo-Gutiérrez, Arturo, additional, Medina-Sanson, Aurora, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, López-Santiago, Norma, additional, Peñaloza-González, José Gabriel, additional, Cortés-Herrera, Beatriz, additional, Merino-Pasaye, Laura Elizabeth, additional, Amador-Sánchez, Raquel, additional, García-López, Luis Ramiro, additional, Pérez-Lorenzana, Héctor, additional, Román-Zepeda, Pedro Francisco, additional, Castañeda-Echevarría, Alejandro, additional, López-Caballero, María Guadalupe, additional, Martínez-Silva, Sofía Irene, additional, Rivera-González, Juan, additional, Granados-Kraulles, Jorge, additional, Flores-Botello, Jesús, additional, Medrano-López, Francisco, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Mora-Rico, Karina, additional, Mora-Ríos, Félix G., additional, R.García‐Cortés, Luis, additional, Salcedo-Lozada, Perla, additional, Flores-Lujano, Janet, additional, Núñez-Enríquez, Juan Carlos, additional, Bekker-Méndez, Vilma Carolina, additional, Mata-Rocha, Minerva, additional, Rosas-Vargas, Haydeé, additional, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Morales, Silvia, additional, Hidalgo-Miranda, Alfredo, additional, López-Carrillo, Lizbeth, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2024
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9. IKZF1plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia.

Author

Garcia-Solorio, Joaquin, Núñez-Enriquez, Juan Carlos, Jiménez-Olivares, Marco, Flores-Lujano, Janet, Flores-Espino, Fernanda, Molina-Garay, Carolina, Cervera, Alejandra, Casique-Aguirre, Diana, Peñaloza-Gonzalez, José Gabriel, Baños-Lara, Ma. Del Rocío, García-Soto, Ángel, Galván-Díaz, César Alejandro, Olaya-Vargas, Alberto, Flores Aguilar, Hilario, Mata-Rocha, Minerva, Garrido-Hernández, Miguel Ángel, Solís-Poblano, Juan Carlos, Luna-Silva, Nuria Citlalli, Cano-Cuapio, Lena Sarahi, and Aristil-Chery, Pierre Mitchel

Subjects
CHILD patients, LYMPHOBLASTIC leukemia, MEXICANS, PROGNOSIS, BIOMARKERS
Abstract

Background: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. IKZF1plus is a complex biomarker associated with a poor prognosis. It is characterized by IKZF1 deletion coexisting with PAX5, CDKN2A/2B, or PAR1 region deletions. The mutational spectrum and clinical impact of these alterations have scarcely been explored in Mexican pediatric patients with B-ALL. Here, we report the frequency of the IKZF1plus profile and the mutational spectrum of IKZF1, PAX5, CDKN2A/2B, and ERG genes and evaluate their impact on overall survival (OS) in a group of patients with B-ALL. Methods: A total of 206 pediatric patients with de novo B-ALL were included. DNA was obtained from bone marrow samples at diagnosis before treatment initiation. A custom-designed next-generation sequencing panel was used for mutational analysis. Kaplan-Meier analysis was used for OS estimation. Results: We identified the IKZF1plus profile in 21.8% of patients, which was higher than that previously reported in other studies. A significantly older age (p=0.04), a trend toward high-risk stratification (p=0.06), and a decrease in 5-year Overall Survival (OS) (p=0.009) were observed, although heterogeneous treatment protocols in our cohort would have impacted OS. A mutation frequency higher than that reported was found for IKZF1 (35.9%) and CDKN2A/2B (35.9%) but lower for PAX5 (26.6%). IKZF1MUT group was older at diagnosis (p=0.0002), and most of them were classified as high-risk (73.8%, p=0.02), while patients with CDKN2A/2BMUT had a higher leukocyte count (p=0.01) and a tendency toward a higher percentage of blasts (98.6%, >50% blasts, p=0.05) than the non-mutated patients. A decrease in OS was found in IKZF1MUT and CDKN2A/2BMUT patients, but the significance was lost after IKZF1plus was removed. Discussion: Our findings demonstrated that Mexican patients with B-ALL have a higher prevalence of genetic markers associated with poor outcomes. Incorporating genomic methodologies into the diagnostic process, a significant unmet need in low- and mid-income countries, will allow a comprehensive identification of relevant alterations, improving disease classification, treatment selection, and the general outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Maternal dietary patterns and acute leukemia in infants: results from a case control study in Mexico

Author

Muñoz-Aguirre, Paloma, primary, Denova-Gutiérrez, Edgar, additional, Pérez-Saldivar, María Luisa, additional, Espinoza-Hernández, Laura E., additional, Dorantes-Acosta, Elisa M., additional, Torres-Nava, José R., additional, Solís-Labastida, Karina A., additional, Paredes-Aguilera, Rogelio, additional, Velázquez-Aviña, Martha M., additional, Espinosa-Elizondo, R. Martha, additional, Miranda-Madrazo, M. Raquel, additional, González-Ávila, Ana Itamar, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier A., additional, Castañeda-Echevarría, Alejandro, additional, López-Caballero, M. Guadalupe, additional, Martínez-Silva, Sofía I., additional, Rivera-González, Juan, additional, Hernández-Pineda, Norma Angélica, additional, Flores-Botello, Jesús, additional, Pérez-Gómez, Jessica Arleet, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Olvera-Durán, Jaime Ángel, additional, Martínez-Ríos, Annel, additional, García-Cortés, Luis R., additional, Almeida-Hernández, Carolina, additional, Flores-Lujano, Janet, additional, Núñez-Enriquez, Juan Carlos, additional, Mata-Rocha, Minerva, additional, Rosas-Vargas, Haydeé, additional, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Morales, Silvia, additional, Mejía-Aranguré, Juan Manuel, additional, and López-Carrillo, Lizbeth, additional

Published
2023
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11. A protective maternal nutrient concomitant intake associated with acute leukemia might be modified by sex, in children under 2 years

Author

Mérida-Ortega, Ángel, primary, Pérez-Saldivar, María Luisa, additional, Espinoza-Hernández, Laura E., additional, Dorantes-Acosta, Elisa M., additional, Torres-Nava, José Refugio, additional, Solís-Labastida, Karina A., additional, Paredes-Aguilera, Rogelio, additional, Velázquez-Aviña, Martha M., additional, Espinosa-Elizondo, Rosa Martha, additional, Miranda-Madrazo, M. Raquel, additional, González-Ávila, Ana Itamar, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier A., additional, Castañeda-Echevarría, Alejandro, additional, López-Caballero, M. Guadalupe, additional, Martínez-Silva, Sofía I., additional, Rivera-González, Juan, additional, Hernández-Pineda, Norma Angélica, additional, Flores-Botello, Jesús, additional, Pérez-Gómez, Jessica Arleet, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Olvera-Durán, Jaime Ángel, additional, Martínez-Ríos, Annel, additional, García‐Cortés, Luis R., additional, Almeida-Hernández, Carolina, additional, Flores-Lujano, Janet, additional, Núñez-Enríquez, Juan Carlos, additional, Mata-Rocha, Minerva, additional, Rosas-Vargas, Haydeé, additional, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Morales, Silvia, additional, Mejía-Arangure, Juan Manuel, additional, and López-Carrillo, Lizbeth, additional

Published
2023
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13. Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

Author

Núñez-Enríquez, Juan Carlos, Gil-Hernández, Ana Elena, Jiménez-Hernández, Elva, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Espinoza-Hernández, Laura Eugenia, Duarte-Rodríguez, David Aldebarán, Amador-Sánchez, Raquel, Peñaloza-González, José Gabriel, Torres-Nava, José Refugio, Espinosa-Elizondo, Rosa Martha, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Pérez-Saldivar, María Luisa, Dorantes-Acosta, Elisa María, Cortés-Herrera, Beatriz, Solis-Labastida, Karina Anastacia, Núñez-Villegas, Nora Nancy, Velázquez-Aviña, Martha Margarita, Rangel-López, Angélica, González-Ávila, Ana Itamar, Santillán-Juárez, Jessica Denisse, García-Velázquez, Alejandra Jimena, Jiménez-Morales, Silvia, Bekker-Méndez, Vilma Carolina, Rosas-Vargas, Haydee, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar Alejandro, Martín-Trejo, Jorge Alfonso, and Mejía-Aranguré, Juan Manuel

Published
2019
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16. Analytical study of RUNX1-RUNXT1, PML-RARA, CBFB-MYH11, BCR-ABL1p210, and KMT2-MLLT3 in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL)

Author

Sepúlveda-Robles, Omar, primary, Jiménez-Hernández, Elva, additional, Domínguez-Catzín, Victoria, additional, Gómez-Flores, Eber, additional, Martín-Trejo, Jorge Alfonso, additional, Flores-Lujano, Janet, additional, Torres-Nava, José Refugio, additional, Núñez-Enríquez, Juan Carlos, additional, De Ita, Marlon, additional, Medina-Sanson, Aurora, additional, Mata-Rocha, Minerva, additional, Morales-Castillo, Blanca Angelica, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Sánchez-Escobar, Norberto, additional, Peñaloza-Gonzalez, José Gabriel, additional, Espinosa-Elizondo, Rosa Martha, additional, Flores-Villegas, Luz Victoria, additional, Amador-Sanchez, Raquel, additional, Orozco-Ruiz, Darío, additional, Pérez-Saldívar, Maria Luisa, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Solís-Labastida, Karina Anastacia, additional, González-Ávila, Ana Itamar, additional, Santillán-Juárez, Jessica Denisse, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Rangel-López, Angélica, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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17. NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia

Author

Valenzuela-Vázquez, Lucero, primary, Nuñez-Enriquez, Juan Carlos, additional, Sánchez-Herrera, Jacqueline, additional, Medina-Sanson, Aurora, additional, Pérez-Saldivar, María Luisa, additional, Jiménez-Hernández, Elva, additional, Martiín-Trejo, Jorge Alfonso, additional, Del Campo-Martínez, María de Los Ángeles, additional, Flores-Lujano, Janet, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Félix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Solís-Labastida, Karina Anastacia, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Velázquez-Aviña, Martha Margarita, additional, Martínez-Ríos, Annel, additional, Aguilar-De los Santos, Antonio, additional, Santillán-Juárez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, García-Velázquez, Alejandra Jimena, additional, Mata-Rocha, Minerva, additional, Hernández-Echáurregui, Gabriela Alicia, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Mancilla-Herrera, Ismael, additional, Jimenez-Morales, Silvia, additional, Hidalgo-Miranda, Alfredo, additional, Martinez-Duncker, Ivan, additional, Waight, Jeremy D., additional, Hance, Kenneth W., additional, Madauss, Kevin P., additional, Mejía-Aranguré, Juan Manuel, additional, and Cruz-Munoz, Mario Ernesto, additional

Published
2022
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18. Persistently high incidence rates of childhood acute leukemias from 2010 to 2017 in Mexico City: A population study from the MIGICCL

Author

Flores-Lujano, Janet, primary, Duarte-Rodríguez, David Aldebarán, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Allende-López, Aldo, additional, Peñaloza-González, José Gabriel, additional, Pérez-Saldivar, María Luisa, additional, Medina-Sanson, Aurora, additional, Torres-Nava, José Refugio, additional, Solís-Labastida, Karina Anastacia, additional, Flores-Villegas, Luz Victoria, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Núñez-Villegas, Nora Nancy, additional, González-Ávila, Ana Itamar, additional, del Campo-Martínez, María de los Ángeles, additional, Alvarado-Ibarra, Martha, additional, Bekker-Méndez, Vilma Carolina, additional, Cárdenas-Cardos, Rocío, additional, Jiménez-Morales, Silvia, additional, Rivera-Luna, Roberto, additional, Rosas-Vargas, Haydee, additional, López-Santiago, Norma C., additional, Rangel-López, Angélica, additional, Hidalgo-Miranda, Alfredo, additional, Vega, Elizabeth, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Arellano-Galindo, José, additional, Núñez-Enríquez, Juan Carlos, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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19. Mutational Landscape of CEBPA in Mexican Pediatric Acute Myeloid Leukemia Patients: Prognostic Implications

Author

Molina Garay, Carolina, primary, Carrillo Sánchez, Karol, additional, Flores Lagunes, Luis Leonardo, additional, Jiménez Olivares, Marco, additional, Muñoz Rivas, Anallely, additional, Villegas Torres, Beatríz Eugenia, additional, Flores Aguilar, Hilario, additional, Núñez Enríquez, Juan Carlos, additional, Jiménez Hernández, Elva, additional, Bekker Méndez, Vilma Carolina, additional, Torres Nava, José Refugio, additional, Flores Lujano, Janet, additional, Martín Trejo, Jorge Alfonso, additional, Mata Rocha, Minerva, additional, Medina Sansón, Aurora, additional, Espinoza Hernández, Laura Eugenia, additional, Peñaloza Gonzalez, José Gabriel, additional, Espinosa Elizondo, Rosa Martha, additional, Flores Villegas, Luz Victoria, additional, Amador Sanchez, Raquel, additional, Pérez Saldívar, María Luisa, additional, Sepúlveda Robles, Omar Alejandro, additional, Rosas Vargas, Haydeé, additional, Jiménez Morales, Silvia, additional, Galindo Delgado, Patricia, additional, Mejía Aranguré, Juan Manuel, additional, and Alaez Verson, Carmen, additional

Published
2022
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20. Underexpression of LINC00173 in TCF3/PBX1-Positive Cases Is Associated With Poor Prognosis in Children With B-Cell Precursor Acute Lymphoblastic Leukemia

Author

May-Hau, Didier Ismael, primary, Bárcenas-López, Diego Alberto, additional, Núñez-Enríquez, Juan Carlos, additional, Bekker-Méndez, Vilma Carolina, additional, Beltrán-Anaya, Fredy Omar, additional, Jiménez-Hernández, Elva, additional, Ortíz-Maganda, Mónica Patricia, additional, Guerra-Castillo, Francisco Xavier, additional, Medina-Sanson, Aurora, additional, Flores-Lujano, Janet, additional, Martín-Trejo, Jorge Alfonso, additional, Peñaloza-González, José Gabriel, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Hernández-Echáurregui, Gabriela Alicia, additional, Espinosa-Elizondo, Rosa Martha, additional, Gutiérrez-Rivera, María de Lourdes, additional, Sanchez-Hernandez, Rodrigo, additional, Pérez-Saldívar, María Luisa, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Duarte-Rodríguez, David Aldebarán, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2022
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21. Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

Author

Mata-Rocha, Minerva, primary, Rangel-López, Angelica, additional, Jimenez-Hernandez, Elva, additional, Nuñez-Enríquez, Juan Carlos, additional, Morales-Castillo, Blanca Angélica, additional, Sánchez-Escobar, Norberto, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Pérez-Saldivar, María Luisa, additional, Flores-Lujano, Janet, additional, Duarte-Rodríguez, David Aldebarán, additional, Oviedo de Anda, Norma Angélica, additional, Romero Tlalolini, Maria de los Angeles, additional, Alaez Verson, Carmen, additional, Martín-Trejo, Jorge Alfonso, additional, Muñoz Medina, Jose Esteban, additional, Gonzalez-Bonilla, Cesar Raul, additional, Hernandez Cueto, Maria de los Angeles, additional, Bekker-Méndez, VC., additional, Jiménez-Morales, Silvia, additional, Medina-Sansón, Aurora, additional, Amador-Sánchez, Raquel, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Gutierrez-Rivera, Maria de Lourdes, additional, Velazquez-Aviña, Martha Margarita, additional, Santillan-Juarez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, Hernández Echáurregui, Gabriela Alicia, additional, Hidalgo-Miranda, Alfredo, additional, Arellano Galindo, José, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2022
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23. Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia

Author

Jiménez-Morales, Silvia, primary, Núñez-Enríquez, Juan Carlos, additional, Cruz-Islas, Jazmín, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Hernández, Elva, additional, Medina-Sanson, Aurora, additional, Olarte-Carrillo, Irma, additional, Martínez-Tovar, Adolfo, additional, Flores-Lujano, Janet, additional, Ramírez-Bello, Julian, additional, Pérez-Saldívar, María Luisa, additional, Martín-Trejo, Jorge Alfonso, additional, Pérez-Lorenzana, Héctor, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Felix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Flores-Bautista, Juan Eduardo, additional, Espinosa-Elizondo, Rosa Martha, additional, Román-Zepeda, Pedro Francisco, additional, Flores-Villegas, Luz Victoria, additional, Tamez-Gómez, Edna Liliana, additional, López-García, Víctor Hugo, additional, Lara-Ramos, José Ramón, additional, González-Ulivarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, García-López, Luis Ramiro, additional, Cruz-Ojeda, Gabriela Adriana, additional, Godoy-Esquivel, Arturo Emilio, additional, Contreras-Hernández, Iris, additional, Medina-Hernández, Abraham, additional, López-Caballero, María Guadalupe, additional, Hernández-Pineda, Norma Angélica, additional, Granados-Kraulles, Jorge, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Cortés-Reyes, Carlos, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Martínez-Ríos, Annel, additional, Aguilar-De-los-Santos, Antonio, additional, Serafin-Díaz, Berenice, additional, Gutiérrez-Rivera, María de Lourdes, additional, Merino-Pasaye, Laura Elizabeth, additional, Vargas-Alarcón, Gilberto, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2021
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24. Development and Validation of a One-Step RT-qPCR Assay for Identifying Common Fusion Gene Transcripts Associated with the Prognosis of Mexican Children with B-Lineage Acute Lymphoblastic Leukemia

Author

Mejía-Aranguré, Juan Manuel, primary, Mata-Rocha, Minerva, additional, Rangel-López, Angelica, additional, Núñez-Enríquez, Juan Carlos, additional, Jiménez-Hernández, Elva, additional, Morales-Castillo, Blanca Angélica, additional, Sánchez-Escobar, Norberto, additional, Sepúlveda-Robles, Omar Alejandro, additional, Bravata-Alcántara, Juan Carlos, additional, Nájera-Cortés, Alan Steve, additional, Pérez-Saldivar, María Luisa, additional, Flores-Lujano, Janet, additional, Duarte-Rodríguez, David Aldebarán, additional, de Anda, Norma Angélica Oviedo, additional, Verson, Carmen Alaez, additional, Martín-Trejo, Jorge Alfonso, additional, Campo-Martínez, María de Los Ángeles Del, additional, Muñoz-Medina, José Esteban, additional, González-Bonilla, César Raúl, additional, Cueto, Maria de los Angeles Hernandez, additional, Medina-Sansón, Aurora, additional, Amador-Sánchez, Raquel, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Solís-Labastida, Karina Anastacia, additional, Velázquez-Aviña, Martha Margarita, additional, Santillán-Juárez, Jessica Denisse, additional, Gurrola-Silva, Alma, additional, García-Velázquez, Alejandra Jimena, additional, Echáurregui, Gabriela Alicia Hernández, additional, and Rosas-Vargas, Haydeé, additional

Published
2021
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25. Copy Number Alterations are Associated with the Risk of Very Early Relapse in Pediatric B-lineage Acute Lymphoblastic Leukemia: A Nested Case-control MIGICCL Study

Author

Rosales-Rodríguez, Beatriz, primary, Núñez-Enríquez, Juan Carlos, additional, Velázquez-Wong, Ana Claudia, additional, González-Torres, Carolina, additional, Gaytán-Cervantes, Javier, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Campo-Martínez, María de los Ángeles del, additional, Medina-Sanson, Aurora, additional, Flores-Lujano, Janet, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Miranda-Madrazo, María Raquel, additional, Santillán-Juárez, Jessica Denise, additional, Pérez-Saldívar, María Luisa, additional, Gurrola-Silva, Alma, additional, Orozco-Ruiz, Darío, additional, Solís-Labastida, Karina Anastacia, additional, Velázquez-Aviña, Martha Margarita, additional, Duarte-Rodríguez, David Aldebarán, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Ortiz-Maganda, Mónica, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Mejía-Aranguré, Juan Manuel, additional, and Rosas-Vargas, Haydeé, additional

Published
2021
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28. Extremely Low‐Frequency Magnetic Fields and the Risk of Childhood B‐Lineage Acute Lymphoblastic Leukemia in a City With High Incidence of Leukemia and Elevated Exposure to ELF Magnetic Fields

Author

Núñez‐Enríquez, Juan C., primary, Correa‐Correa, Víctor, additional, Flores‐Lujano, Janet, additional, Pérez‐Saldivar, María L., additional, Jiménez‐Hernández, Elva, additional, Martín‐Trejo, Jorge A., additional, Espinoza‐Hernández, Laura E., additional, Medina‐Sanson, Aurora, additional, Cárdenas‐Cardos, Rocío, additional, Flores‐Villegas, Luz V., additional, Peñaloza‐González, José G., additional, Torres‐Nava, José R., additional, Espinosa‐Elizondo, Rosa M., additional, Amador‐Sánchez, Raquel, additional, Rivera‐Luna, Roberto, additional, Dosta‐Herrera, Juan J., additional, Mondragón‐García, Javier A., additional, González‐Ulibarri, Juana E., additional, Martínez‐Silva, Sofía I., additional, Espinoza‐Anrubio, Gilberto, additional, Duarte‐Rodríguez, David A., additional, García‐Cortés, Luis R., additional, Gil‐Hernández, Ana E., additional, and Mejía‐Aranguré, Juan M., additional

Published
2020
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29. Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Author

Medina-Sanson, Aurora, primary, Núñez-Enríquez, Juan Carlos, additional, Hurtado-Cordova, Eduardo, additional, Pérez-Saldivar, María Luisa, additional, Martínez-García, Anayeli, additional, Jiménez-Hernández, Elva, additional, Fernández-López, Juan Carlos, additional, Martín-Trejo, Jorge Alfonso, additional, Pérez-Lorenzana, Héctor, additional, Flores-Lujano, Janet, additional, Amador-Sánchez, Raquel, additional, Mora-Ríos, Felix Gustavo, additional, Peñaloza-González, José Gabriel, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Flores-Bautista, Juan Eduardo, additional, Espinosa-Elizondo, Rosa Martha, additional, Román-Zepeda, Pedro Francisco, additional, Flores-Villegas, Luz Victoria, additional, González-Ulivarri, Juana Esther, additional, Martínez-Silva, Sofía Irene, additional, Espinoza-Anrubio, Gilberto, additional, Almeida-Hernández, Carolina, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, García-López, Luis Ramiro, additional, Cruz-Ojeda, Gabriela Adriana, additional, Godoy-Esquivel, Arturo Emilio, additional, Contreras-Hernández, Iris, additional, Medina-Hernández, Abraham, additional, López-Caballero, María Guadalupe, additional, Hernández-Pineda, Norma Angélica, additional, Granados-Kraulles, Jorge, additional, Rodríguez-Vázquez, María Adriana, additional, Torres-Valle, Delfino, additional, Cortés-Reyes, Carlos, additional, Medrano-López, Francisco, additional, Pérez-Gómez, Jessica Arleet, additional, Martínez-Ríos, Annel, additional, Aguilar-De los Santos, Antonio, additional, Serafin-Díaz, Berenice, additional, Bekker-Méndez, Vilma Carolina, additional, Mata-Rocha, Minerva, additional, Morales-Castillo, Blanca Angélica, additional, Sepúlveda-Robles, Omar Alejandro, additional, Ramírez-Bello, Julián, additional, Rosas-Vargas, Haydeé, additional, Hidalgo-Miranda, Alfredo, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2020
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30. Profiling FLT3 Mutations in Mexican Acute Myeloid Leukemia Pediatric Patients: Impact on Overall Survival

Author

Molina Garay, Carolina, primary, Carrillo Sánchez, Karol, additional, Flores Lagunes, Luis Leonardo, additional, Jiménez Olivares, Marco, additional, Muñoz Rivas, Anallely, additional, Villegas Torres, Beatríz Eugenia, additional, Flores Aguilar, Hilario, additional, Núñez Enríquez, Juan Carlos, additional, Jiménez Hernández, Elva, additional, Bekker Méndez, Vilma Carolina, additional, Torres Nava, José Refugio, additional, Flores Lujano, Janet, additional, Martín Trejo, Jorge Alfonso, additional, Mata Rocha, Minerva, additional, Medina Sansón, Aurora, additional, Espinoza Hernández, Laura Eugenia, additional, Peñaloza Gonzalez, José Gabriel, additional, Espinosa Elizondo, Rosa Martha, additional, Flores Villegas, Luz Victoria, additional, Amador Sanchez, Raquel, additional, Pérez Saldívar, Maria Luisa, additional, Sepúlveda Robles, Omar Alejandro, additional, Rosas Vargas, Haydeé, additional, Rangel López, Angélica, additional, Domínguez López, María Lilia, additional, García Latorre, Ethel Awilda, additional, Reyes Maldonado, Elba, additional, Galindo Delgado, Patricia, additional, Mejía Aranguré, Juan Manuel, additional, and Alaez Verson, Carmen, additional

Published
2020
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31. Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia

Author

Bárcenas-López, Diego Alberto, primary, Núñez-Enríquez, Juan Carlos, additional, Hidalgo-Miranda, Alfredo, additional, Beltrán-Anaya, Fredy Omar, additional, May-Hau, Didier Ismael, additional, Jiménez-Hernández, Elva, additional, Bekker-Méndez, Vilma Carolina, additional, Flores-Lujano, Janet, additional, Medina-Sansón, Aurora, additional, Tamez-Gómez, Edna Liliana, additional, López-García, Víctor Hugo, additional, Lara-Ramos, José Ramón, additional, Núñez-Villegas, Nora Nancy, additional, Peñaloza-González, José Gabriel, additional, Flores-Villegas, Luz Victoria, additional, Amador-Sánchez, Raquel, additional, Espinosa-Elizondo, Rosa Martha, additional, Martín-Trejo, Jorge Alfonso, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, Pérez-Saldívar, María Luisa, additional, Duarte-Rodríguez, David Aldebarán, additional, Torres-Nava, José Refugio, additional, Cortés-Herrera, Beatriz, additional, Solís-Labastida, Karina Anastacia, additional, González-Ávila, Ana Itamar, additional, Santillán-Juárez, Jessica Denisse, additional, García-Velázquez, Alejandra Jimena, additional, Rosas-Vargas, Haydee, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, Mejía-Aranguré, Juan Manuel, additional, and Jiménez-Morales, Silvia, additional

Published
2020
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32. Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Author

Valenzuela-Vazquez, Lucero, primary, Núñez-Enríquez, Juan Carlos, additional, Sánchez-Herrera, Jacqueline, additional, Jiménez-Hernández, Elva, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Medina-Sanson, Aurora, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, Refugio Torres-Nava, José, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Santillán-Juárez, Jessica Denisse, additional, Flores-Lujano, Janet, additional, Pérez-Saldívar, María Luisa, additional, García-López, Luis Ramiro, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Leyva, Francisco, additional, Rosas-Vargas, Haydeé, additional, Mata-Rocha, Minerva, additional, Duarte-Rodríguez, David Aldebarán, additional, Sepúlveda-Robles, Omar Alejandro, additional, Mancilla-Herrera, Ismael, additional, Mejía-Aranguré, Juan Manuel, additional, and Cruz-Munoz, Mario Ernesto, additional

Published
2020
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33. Additional file 1: of Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

Author

Núñez-Enríquez, Juan, Gil-Hernández, Ana, Jiménez-Hernández, Elva, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Espinoza-Hernández, Laura, Duarte-Rodríguez, David, Amador-Sánchez, Raquel, Peñaloza-González, José, Torres-Nava, José, Espinosa-Elizondo, Rosa, Flores-Villegas, Luz, Merino-Pasaye, Laura, Pérez-Saldivar, María, Dorantes-Acosta, Elisa, Cortés-Herrera, Beatriz, Solis-Labastida, Karina, Núñez-Villegas, Nora, Velázquez-Aviña, Martha, Rangel-López, Angélica, González-Ávila, Ana, Santillán-Juárez, Jessica, García-Velázquez, Alejandra, Jiménez-Morales, Silvia, Bekker-Méndez, Vilma, Rosas-Vargas, Haydee, Mata-Rocha, Minerva, Sepúlveda-Robles, Omar, Martín-Trejo, Jorge, and Mejía-Aranguré, Juan

Abstract

Table S1. Comparison of overweight and obesity prevalence at diagnosis using CDC and WHO in ALL children. (DOCX 13 kb)

Published
2019
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34. Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Author

Mata-Rocha, Minerva, primary, Rangel-López, Angelica, additional, Jiménez-Hernández, Elva, additional, Morales-Castillo, Blanca Angélica, additional, González-Torres, Carolina, additional, Gaytan-Cervantes, Javier, additional, Álvarez-Olmos, Enrique, additional, Núñez-Enríquez, Juan Carlos, additional, Fajardo-Gutiérrez, Arturo, additional, Martín-Trejo, Jorge Alfonso, additional, Solís-Labastida, Karina Anastacia, additional, Medina-Sansón, Aurora, additional, Flores-Lujano, Janet, additional, Sepúlveda-Robles, Omar Alejandro, additional, Peñaloza-González, José Gabriel, additional, Espinoza-Hernández, Laura Eugenia, additional, Núñez-Villegas, Nora Nancy, additional, Espinosa-Elizondo, Rosa Martha, additional, Cortés-Herrera, Beatriz, additional, Torres-Nava, José Refugio, additional, Flores-Villegas, Luz Victoria, additional, Merino-Pasaye, Laura Elizabeth, additional, Bekker-Méndez, Vilma Carolina, additional, Velázquez-Aviña, Martha Margarita, additional, Pérez-Saldívar, María Luisa, additional, Bautista-Martínez, Benito Alejandro, additional, Amador-Sánchez, Raquel, additional, González-Avila, Ana Itamar, additional, Jiménez-Morales, Silvia, additional, Duarte-Rodríguez, David Aldebarán, additional, Santillán-Juárez, Jessica Denisse, additional, García-Velázquez, Alejandra Jimena, additional, Rosas-Vargas, Haydeé, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2019
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35. Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

Author

Bekker-Méndez Vilma, Alamilla-Galicia Paola, Cárdenas-Cardos Rocío, del Campo-Martínez María, Paredes-Aguilera Rogelio, Duarte-Rodríguez David, Torres-Nava José, Velázquez-Aviña Martha, Jiménez-Hernández Elva, Alvarado-Ibarra Martha, Dorantes-Acosta Elisa, Rivera-Luna Roberto, Rodríguez-Zepeda María, Flores-Lujano Janet, Bolea-Murga Victoria, Álvarez-Rodríguez Francisco, Amador-Sánchez Raquel, Peñaloza-González José, Flores-Chapa José, Medina-Sanson Aurora, Espinosa-Hernández Laura, Martínez-Avalos Armando, Bernáldez-Ríos Roberto, Fajardo-Gutiérrez Arturo, Pérez-Saldivar María, Ortega-Alvarez Manuel, and Mejia-Arangure Juan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Worldwide, acute leukemia is the most common type of childhood cancer. It is particularly common in the Hispanic populations residing in the United States, Costa Rica, and Mexico City. The objective of this study was to determine the incidence of acute leukemia in children who were diagnosed and treated in public hospitals in Mexico City. Methods Included in this study were those children, under 15 years of age and residents of Mexico City, who were diagnosed in 2006 and 2007 with leukemia, as determined by using the International Classification of Childhood Cancer. The average annual incidence rates (AAIR), and the standardized average annual incidence rates (SAAIR) per million children were calculated. We calculated crude, age- and sex-specific incidence rates and adjusted for age by the direct method with the world population as standard. We determined if there were a correlation between the incidence of acute leukemias in the various boroughs of Mexico City and either the number of agricultural hectares, the average number of persons per household, or the municipal human development index for Mexico (used as a reference of socio-economic level). Results Although a total of 610 new cases of leukemia were registered during 2006-2007, only 228 fit the criteria for inclusion in this study. The overall SAAIR was 57.6 per million children (95% CI, 46.9-68.3); acute lymphoblastic leukemia (ALL) was the most frequent type of leukemia, constituting 85.1% of the cases (SAAIR: 49.5 per million), followed by acute myeloblastic leukemia at 12.3% (SAAIR: 6.9 per million), and chronic myeloid leukemia at 1.7% (SAAIR: 0.9 per million). The 1-4 years age group had the highest SAAIR for ALL (77.7 per million). For cases of ALL, 73.2% had precursor B-cell immunophenotype (SAAIR: 35.8 per million) and 12.4% had T-cell immunophenotype (SAAIR 6.3 per million). The peak ages for ALL were 2-6 years and 8-10 years. More than half the children (58.8%) were classified as high risk. There was a positive correlation between the average number of persons per household and the incidence of the pre-B immunophenotype (Pearson's r, 0.789; P = 0.02). Conclusions The frequency of ALL in Mexico City is among the highest in the world, similar to those found for Hispanics in the United States and in Costa Rica.

Published
2011
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36. Father's occupational exposure to carcinogenic agents and childhood acute leukemia: a new method to assess exposure (a case-control study)

Author

Rodriguez-Rivera Maria, Borja-Aburto Victor, Martínez-Avalos Armando, Paredes-Aguilera Rogelio, Palomo-Colli Miguel, Medina-Sanson Aurora, del Campo-Martinez Maria, Bernaldez-Rios Roberto, Fajardo-Gutierrez Arturo, Ortega-Alvarez Manuel, Perez-Saldivar Maria, Vargas-Garcia Victor, Zarco-Contreras Jesus, Flores-Lujano Janet, and Mejia-Arangure Juan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Medical research has not been able to establish whether a father's occupational exposures are associated with the development of acute leukemia (AL) in their offspring. The studies conducted have weaknesses that have generated a misclassification of such exposure. Occupations and exposures to substances associated with childhood cancer are not very frequently encountered in the general population; thus, the reported risks are both inconsistent and inaccurate. In this study, to assess exposure we used a new method, an exposure index, which took into consideration the industrial branch, specific position, use of protective equipment, substances at work, degree of contact with such substances, and time of exposure. This index allowed us to obtain a grade, which permitted the identification of individuals according to their level of exposure to known or potentially carcinogenic agents that are not necessarily specifically identified as risk factors for leukemia. The aim of this study was to determine the association between a father's occupational exposure to carcinogenic agents and the presence of AL in their offspring. Methods From 1999 to 2000, a case-control study was performed with 193 children who reside in Mexico City and had been diagnosed with AL. The initial sample-size calculation was 150 children per group, assessed with an expected odds ratio (OR) of three and a minimum exposure frequency of 15.8%. These children were matched by age, sex, and institution with 193 pediatric surgical patients at secondary-care hospitals. A questionnaire was used to determine each child's background and the characteristics of the father's occupation(s). In order to determine the level of exposure to carcinogenic agents, a previously validated exposure index (occupational exposure index, OEI) was used. The consistency and validity of the index were assessed by a questionnaire comparison, the sensory recognition of the work area, and an expert's opinion. Results The adjusted ORs and 95% confidence intervals (CI) were 1.69 (0.98, 2.92) during the preconception period; 1.98 (1.13, 3.45) during the index pregnancy; 2.11 (1.17, 3.78) during breastfeeding period; 2.17 (1.28, 3.66) after birth; and 2.06 (1.24, 3.42) for global exposure. Conclusion This is the first study in which an OEI was used to assess a father's occupational exposure to carcinogenic agents as a risk factor for the development of childhood AL in his offspring. From our results, we conclude that children whose fathers have been exposed to a high level of carcinogenic agents seem to have a greater risk of developing acute leukemia. However, confounding factors cannot be disregarded due to an incomplete control for confounding.

Published
2008
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37. Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium

Author

Metayer, Catherine, Petridou, Eleni, Aranguré, Juan Manuel Mejía, Roman, Eve, Schüz, Joachim, Magnani, Corrado, Mora, Ana Maria, Mueller, Beth A., De Oliveira, Maria S.Pombo, Dockerty, John D., McCauley, Kathryn, Lightfoot, Tracy, Hatzipantelis, Emmanouel, Rudant, Jérémie, Flores-Lujano, Janet, Kaatsch, Peter, Miligi, Lucia, Wesseling, Catharina, Doody, David R., Moschovi, Maria, Orsi, Laurent, Mattioli, Stefano, Selvin, Steve, Kang, Alice Y., Clavel, Jacqueline, Nuñez-Enriquez, Juan Carlos, Jiménez-Hernández, Elva, Paredes-Aguilera, Rogelio, Metayer, Catherine, Petridou, Eleni, Aranguré, Juan Manuel Mejía, Roman, Eve, Schüz, Joachim, Magnani, Corrado, Mora, Ana Maria, Mueller, Beth A., De Oliveira, Maria S. Pombo, Dockerty, John D., Mccauley, Kathryn, Lightfoot, Tracy, Hatzipantelis, Emmanouel, Rudant, Jérémie, Flores-Lujano, Janet, Kaatsch, Peter, Miligi, Lucia, Wesseling, Catharina, Doody, David R., Moschovi, Maria, Orsi, Laurent, Mattioli, Stefano, Selvin, Steve, Kang, Alice Y., Clavel, Jacqueline, Nuñez-Enriquez, Juan Carlo, Jiménez-Hernández, Elva, and Paredes-Aguilera, Rogelio

Subjects
Adult, Male, Parents, Risk, medicine.medical_specialty, Adolescent, Childhood leukemia, Epidemiology, Socio-culturale, acute myeloid leukemia, Tobacco smoke, 03 medical and health sciences, 0302 clinical medicine, Economica, Pregnancy, Internal medicine, Odds Ratio, medicine, Humans, childhood cancer, 030212 general & internal medicine, Child, Psychiatry, parental smoking, business.industry, Medicine (all), Case-control study, Infant, Myeloid leukemia, Ambientale, Odds ratio, medicine.disease, Confidence interval, Leukemia, Myeloid, Acute, Socioeconomic Factors, Case-Control Studies, Child, Preschool, Prenatal Exposure Delayed Effects, 030220 oncology & carcinogenesis, international collaboration, Female, Tobacco Smoke Pollution, business, Systematic Reviews and Meta- and Pooled Analyses
Abstract

The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age

Published
2016

38. Frecuencia, tipo y predictores de complicaciones pleuropulmonares en los primeros treinta días del postoperatorio de pacientes pediátricos intervenidos de cirugía cardiovascular sin apoyo de circulación extracorpórea

Author

Hernández-López, Jessica Jacqueline, primary, Solano-Gutiérrez, Alejandro, additional, Rosas-Aragón, Flor Teresita, additional, Antúnez-Soto, Airam Gabriela, additional, Flores-Lujano, Janet, additional, and Nuñez-Enríquez, Juan Carlos, additional

Published
2018
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39. A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)

Author

Jiménez-Hernández, Elva, primary, Fajardo-Gutiérrez, Arturo, additional, Núñez-Enriquez, Juan Carlos, additional, Martín-Trejo, Jorge Alfonso, additional, Espinoza-Hernández, Laura Eugenia, additional, Flores-Lujano, Janet, additional, Arellano-Galindo, José, additional, Medina-Sanson, Aurora, additional, Paredes-Aguilera, Rogelio, additional, Merino-Pasaye, Laura Elizabeth, additional, Velázquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Espinosa-Elizondo, Rosa Martha, additional, Amador-Sánchez, Raquel, additional, Dosta-Herrera, Juan José, additional, Mondragón-García, Javier Anastacio, additional, Valdés-Guzmán, Heriberto, additional, Mejía-Pérez, Laura, additional, Espinoza-Anrubio, Gilberto, additional, Paz-Bribiesca, María Minerva, additional, Salcedo-Lozada, Perla, additional, Landa-García, Rodolfo Ángel, additional, Ramírez-Colorado, Rosario, additional, Hernández-Mora, Luis, additional, Pérez-Saldivar, María Luisa, additional, Santamaría-Ascencio, Marlene, additional, López-Loyola, Anselmo, additional, Godoy-Esquivel, Arturo Hermilo, additional, García-López, Luis Ramiro, additional, Anguiano-Ávalos, Alison Ireri, additional, Mora-Rico, Karina, additional, Castañeda-Echevarría, Alejandro, additional, Rodríguez-Jiménez, Roberto, additional, Cibrian-Cruz, José Alberto, additional, Solís-Labastida, Karina Anastacia, additional, Cárdenas-Cardos, Rocío, additional, Martínez-Avalos, Armando, additional, Flores-Villegas, Luz Victoria, additional, Peñaloza-González, José Gabriel, additional, González-Ávila, Ana Itamar, additional, Altamirano-García, Martha Beatriz, additional, López-Santiago, Norma, additional, Sánchez-Ruiz, Martin, additional, Rivera-Luna, Roberto, additional, Rodríguez-Villalobos, Luis Rodolfo, additional, Hernández-Pérez, Francisco, additional, Olvera-Durán, Jaime Ángel, additional, García-Cortés, Luis Rey, additional, Mata-Rocha, Minerva, additional, Sepúlveda-Robles, Omar Alejandro, additional, González-Bonilla, Cesar Raúl, additional, Bekker-Méndez, Vilma Carolina, additional, Jiménez-Morales, Silvia, additional, Rosas-Vargas, Haydee, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2018
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40. Parental Tobacco Smoking and Acute Myeloid Leukemia The Childhood Leukemia International Consortium

Author

Metayer, Catherine Petridou, Eleni Mejia Arangure, Juan Manuel and Roman, Eve Schuz, Joachim Magnani, Corrado Maria Mora, Ana Mueller, Beth A. Pombo de Oliveira, Maria S. Dockerty, John D. McCauley, Kathryn Lightfoot, Tracy Hatzipantelis, Emmanouel Rudant, Jeremie Flores-Lujano, Janet Kaatsch, Peter Miligi, Lucia Wesseling, Catharina Doody, David R. and Moschovi, Maria Orsi, Laurent Mattioli, Stefano Selvin, Steve Kang, Alice Y. Clavel, Jacqueline MIGICCL Grp

Abstract

The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age < 15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.

Published
2016

41. ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study

Author

Bekker-Méndez, Vilma Carolina, primary, Núñez-Enríquez, Juan Carlos, additional, Torres Escalante, José Luis, additional, Alvarez-Olmos, Enrique, additional, González-Montalvoc, Pablo Miguel, additional, Jiménez-Hernández, Elva, additional, Sansón, Aurora Medina, additional, Leal, Yelda A., additional, Ramos-Cervantes, María Teresa, additional, Guerra-Castillo, Francisco Xavier, additional, Ortiz-Maganda, Mónica Patricia, additional, Flores-Lujano, Janet, additional, Pérez-Saldivar, Maria Luisa, additional, Velazquez-Aviña, Martha Margarita, additional, Bolea-Murga, Victoria, additional, Torres-Nava, José Refugio, additional, Amador-Sanchez, Raquel, additional, Solis-Labastida, Karina Anastacia, additional, Rámirez-Bello, Julian, additional, Fragoso, José Manuel, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2016
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42. Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients

Author

Jiménez-Morales, Silvia, primary, Ramírez-Florencio, Mireya, additional, Mejía-Aranguré, Juan Manuel, additional, Núñez-Enríquez, Juan Carlos, additional, Bekker-Mendez, Carolina, additional, Torres-Escalante, José Luis, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, del Carmen Rodríguez-Zepeda, María, additional, Leal, Yelda A., additional, González-Montalvo, Pablo Miguel, additional, Pantoja-Guillen, Francisco, additional, Peñaloza-Gonzalez, José Gabriel, additional, Gutiérrez-Juárez, Erick Israel, additional, Núñez-Villegas, Nora Nancy, additional, Pérez-Saldivar, Maria Luisa, additional, Guerra-Castillo, Francisco Xavier, additional, Flores-Villegas, Luz Victoria, additional, Ramos-Cervantes, María Teresa, additional, Fragoso, José Manuel, additional, García-Escalante, María Guadalupe, additional, del Carmen Pinto-Escalante, Doris, additional, Ramírez-Bello, Julián, additional, and Hidalgo-Miranda, Alfredo, additional

Published
2016
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43. Copy Number Alterations Associated with Acute Lymphoblastic Leukemia in Mexican Children. A report from The Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

Author

Rosales-Rodríguez, Beatriz, primary, Fernández-Ramírez, Fernando, additional, Núñez-Enríquez, Juan Carlos, additional, Velázquez-Wong, Ana Claudia, additional, Medina-Sansón, Aurora, additional, Jiménez-Hernández, Elva, additional, Flores-Lujano, Janet, additional, Peñaloza-González, José Gabriel, additional, Espinosa-Elizondo, Rosa Martha, additional, Pérez-Saldívar, María Luisa, additional, Torres-Nava, José Refugio, additional, Martín-Trejo, Jorge Alfonso, additional, Martínez-Morales, Gabriela Bibiana, additional, Bekker-Méndez, Vilma Carolina, additional, Mejía-Aranguré, Juan Manuel, additional, and Rosas-Vargas, Haydee, additional

Published
2016
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44. Parental Exposure to Workplace Carcinogens and the Risk of Development of Acute Leukemia in Infants. Case-Control Study

Author

Pérez-Saldivar, María Luisa, primary, Fajardo-Gutiérrez, Arturo, additional, Sierra-Ramírez, José Alfredo, additional, Núñez-Villegas, Nancy, additional, Pérez-Lorenzana, Héctor, additional, Dorantes-Acosta, Elisa María, additional, Román-Zepeda, Pedro Francisco, additional, Rodríguez-Zepeda, María del Carmen, additional, González-Ulivarri, Juana Esther, additional, López-Santiago, Norma, additional, Martínez-Silva, Sofía Irene, additional, Paredes-Aguilera, Rogelio, additional, Velázquez-Aviña, Martha Margarita, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, Núñez-Enríquez, Juan Carlos, additional, Bekker-Méndez, Vilma Carolina, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2016
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45. Gene Expression Profiling of Acute Lymphoblastic Leukemia in Children with Very Early Relapse

Author

Núñez-Enríquez, Juan Carlos, primary, Bárcenas-López, Diego Alberto, additional, Hidalgo-Miranda, Alfredo, additional, Jiménez-Hernández, Elva, additional, Bekker-Méndez, Vilma Carolina, additional, Flores-Lujano, Janet, additional, Solis-Labastida, Karina Anastacia, additional, Martínez-Morales, Gabriela Bibiana, additional, Sánchez-Muñoz, Fausto, additional, Espinoza-Hernández, Laura Eugenia, additional, Velázquez-Aviña, Martha Margarita, additional, Merino-Pasaye, Laura Elizabeth, additional, García Velázquez, Alejandra Jimena, additional, Pérez-Saldívar, María Luisa, additional, Mojica-Espinoza, Raúl, additional, Ramírez-Bello, Julián, additional, Jiménez-Morales, Silvia, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2016
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46. Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study

Author

Martín-Trejo, Jorge Alfonso, primary, Núñez-Enríquez, Juan Carlos, additional, Fajardo-Gutiérrez, Arturo, additional, Medina-Sansón, Aurora, additional, Flores-Lujano, Janet, additional, Jiménez-Hernández, Elva, additional, Amador-Sanchez, Raquel, additional, Peñaloza-Gonzalez, José Gabriel, additional, Alvarez-Rodriguez, Francisco Javier, additional, Bolea-Murga, Victoria, additional, Espinosa-Elizondo, Rosa Martha, additional, de Diego Flores-Chapa, José, additional, Pérez-Saldivar, Maria Luisa, additional, Rodriguez-Zepeda, María del Carmen, additional, Dorantes-Acosta, Elisa María, additional, Núñez-Villegas, Nora Nancy, additional, Velazquez-Aviña, Martha Margarita, additional, Torres-Nava, José Refugio, additional, Reyes-Zepeda, Nancy Carolina, additional, González-Bonilla, César Raúl, additional, Flores-Villegas, Luz Victoria, additional, Rangel-López, Angélica, additional, Rivera-Luna, Roberto, additional, Paredes-Aguilera, Rogelio, additional, Cárdenas-Cardós, Rocío, additional, Martínez-Avalos, Armando, additional, Gil-Hernández, Ana Elena, additional, Duarte-Rodríguez, David Aldebarán, additional, and Mejía-Aranguré, Juan Manuel, additional

Published
2016
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49. Factores predictores de hiperglucemia postoperatoria severa en pacientes pediátricos de cirugía cardiac.

Author

Marín-Vivas, Ramón Raúl, Saldívar-Müller, Cecilio Ernesto, Sánchez-Bañuelos, Cecilia Consuelo, Flores-Lujano, Janet, and Núñez-Enríquez, Juan Carlos

Abstract

Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

50. Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study.

Author

Martín-Trejo, Jorge Alfonso, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Jiménez-Hernández, Elva, Amador-Sanchez, Raquel, Peñaloza-Gonzalez, José Gabriel, Alvarez-Rodriguez, Francisco Javier, Bolea-Murga, Victoria, Espinosa-Elizondo, Rosa Martha, de Diego Flores-Chapa, José, Pérez-Saldivar, Maria Luisa, Rodriguez-Zepeda, María del Carmen, Dorantes-Acosta, Elisa María, Núñez-Villegas, Nora Nancy, Velazquez-Aviña, Martha Margarita, Torres-Nava, José Refugio, Reyes-Zepeda, Nancy Carolina, and González-Bonilla, César Raúl

Subjects
LYMPHOBLASTIC leukemia in children, LEUKEMIA in children, MALNUTRITION diagnosis, NUTRITION disorders in children, CHILDREN'S health, DIAGNOSIS, LEUKEMIA treatment
Abstract

The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient’s age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08–4.01) was observed in the group of malnourished children with a high-risk ALL. [ABSTRACT FROM AUTHOR]

Published
2017
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