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BACKGROUND The objectives of this study are to estimate the prevalence of iron deficiency (ID) among French whole-blood (WB) donors to identify factors associated with ID and to generate decision trees. STUDY DESIGN AND METHODS A prospective National multicentre study was performed on WB donors from March 11, to April 5th, 2019. Samples were selected randomly to perform serum ferritin. ID was defined as ferritin value under 26 ng/ml. All results were stratified by sex. Factors associated with ID were analysed using multivariate logistic regression model. CART algorithm was used for decision trees. RESULTS Eleven thousand two hundred fifty eight WB donors were included. ID was more frequent in women (39·5%) than in men (18·0%). Among 7200 repeated donors, women below 50 yo had a higher risk (OR = 2·37; [1·97-2·85] IC95) than those above 50 yo. Factors associated with ID were: haemoglobin level under the threshold at donation n-1 except for women and n-2 donation; a low mean corpuscular haemoglobin at n-1 and n-2 donations; a shorter interval since n-1 donation and between n-1 and n-2 donations except for women; and women who had given three or four times in the last year. CART algorithm defined high risk of ID subgroups within three populations of donors, new female donors, repeated male donors and repeated female donors. In these identified subgroups, prevalence of ID was up to 72·1%. CONCLUSIONS Our study showed the high prevalence of ID among French WB donors, identified well-known and new factors associated with ID and defined algorithms predicting ID in three populations.

La carence en fer (CF) chez les donneurs de sang (DDS) est un probleme sous-estime et peut entrainer des symptomes, meme en l’absence d’anemie. La prevention de la CF repose principalement sur la prevention de l’anemie chez les donneurs de sang total (ST), en ajournant lorsque le taux d’hemoglobine (Hb) est inferieur a un seuil (120 g/L femmes, 130 g/L hommes en France). L’objectif est d’estimer la prevalence de la CF chez les donneurs de ST en France et d’identifier les facteurs de risque (FdR) associes a cette CF. Une etude transversale, multicentrique a ete effectuee chez les donneurs de l’EFS et du CTSA. Tous les candidats au don de ST repondant aux criteres de selection etaient potentiellement inclus a l’exclusion des dons-saignees et des refus de participation a l’etude. La ferritine a ete dosee sur des tubes reorientes d’echantillons tires au sort, issus de collectes mobiles et en sites fixes du 11 au 28 mars 2019. La CF a ete definie par une ferritinemie