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Your search keyword '"Floor, Evelien"' showing total 6 results
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6 results on '"Floor, Evelien"'

3. Multiplex spatial omics reveals changes in immune-epithelial crosstalk during inflammation and dysplasia development in chronic IBD patients

Author

CMM, CMM Groep Vercoulen, Cancer, MS MDL 1, Infection & Immunity, CMM USEQ Facility, Unit Opleiding MDL, CTI, CTI Computational Immunology Core, Pathologie Pathologen staf, Baars, Matthijs J.D., Floor, Evelien, Sinha, Neeraj, ter Linde, José J.M., van Dam, Stephanie, Amini, Mojtaba, Nijman, Isaäc J., ten Hove, Joren R., Drylewicz, Julia, Offerhaus, G. Johan A., Laclé, Miangela M., Oldenburg, Bas, Vercoulen, Yvonne, CMM, CMM Groep Vercoulen, Cancer, MS MDL 1, Infection & Immunity, CMM USEQ Facility, Unit Opleiding MDL, CTI, CTI Computational Immunology Core, Pathologie Pathologen staf, Baars, Matthijs J.D., Floor, Evelien, Sinha, Neeraj, ter Linde, José J.M., van Dam, Stephanie, Amini, Mojtaba, Nijman, Isaäc J., ten Hove, Joren R., Drylewicz, Julia, Offerhaus, G. Johan A., Laclé, Miangela M., Oldenburg, Bas, and Vercoulen, Yvonne

Published
2024

4. Stromal localization of inactive CD8 + T cells in metastatic mismatch repair deficient colorectal cancer.

Author

Lab Translational Oncology, Cancer, CMM, CMM Groep Vercoulen, Infection & Immunity, Unit Opleiding Aios, Onderzoek Medische Oncologie, MS MDL 1, MS Radiotherapie, MS CGO, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Küçükköse, Emre, Baars, Matthijs J.D., Amini, Mojtaba, Schraa, Suzanna J., Floor, Evelien, Bol, Guus M., Borel Rinkes, Inne H.M., Roodhart, Jeanine M.L., Koopman, Miriam, Laoukili, Jamila, Kranenburg, Onno, Vercoulen, Yvonne, Lab Translational Oncology, Cancer, CMM, CMM Groep Vercoulen, Infection & Immunity, Unit Opleiding Aios, Onderzoek Medische Oncologie, MS MDL 1, MS Radiotherapie, MS CGO, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Küçükköse, Emre, Baars, Matthijs J.D., Amini, Mojtaba, Schraa, Suzanna J., Floor, Evelien, Bol, Guus M., Borel Rinkes, Inne H.M., Roodhart, Jeanine M.L., Koopman, Miriam, Laoukili, Jamila, Kranenburg, Onno, and Vercoulen, Yvonne

Published
2024

5. Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer

Author

Kucukkose, Emre, primary, Baars, Matthijs J.D., additional, Amini, Mojtaba, additional, Schraa, Suzanna J., additional, Floor, Evelien, additional, Bol, Guus M., additional, Rinkes, Inne H.M. Borel, additional, Roodhart, Jeanine M.L., additional, Koopman, Miriam, additional, Laoukili, Jamila, additional, Kranenburg, Onno, additional, and Vercoulen, Yvonne, additional

Published
2023
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6. Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer.

Author

Küçükköse, Emre, Baars, Matthijs J. D., Amini, Mojtaba, Schraa, Suzanna J., Floor, Evelien, Bol, Guus M., Borel Rinkes, Inne H. M., Roodhart, Jeanine M. L., Koopman, Miriam, Laoukili, Jamila, Kranenburg, Onno, and Vercoulen, Yvonne

Abstract

Background: The determinants of metastasis in mismatch repair deficiency with high levels of microsatellite instability (MSI-H) in colorectal cancer (CRC) are poorly understood. Here, we hypothesized that distinct immune and stromal microenvironments in primary tumors may discriminate between non-metastatic MSI-H CRC and metastatic MSI-H CRC. Methods: We profiled 46,727 single cells using high-plex imaging mass cytometry and analyzed both differential cell type abundance, and spatial distribution of fibroblasts and immune cells in primary CRC tumors with or without metastatic capacity. We validated our findings in a second independent cohort using immunohistochemistry. Results: High-plex imaging mass cytometry and hierarchical clustering based on microenvironmental markers separated primary MSI-H CRC tumors with and without metastatic capacity. Primary tumors with metastatic capacity displayed a high stromal content and low influx of CD8+ T cells, which expressed significantly lower levels of markers reflecting proliferation (Ki67) and antigen-experience (CD45RO) compared to CD8+ T cells in non-metastatic tumors. CD8+ T cells showed intra-epithelial localization in non-metastatic tumors, but stromal localization in metastatic tumors, which was validated in a second cohort. Conclusion: We conclude that localization of phenotypically distinct CD8+ T cells within stroma may predict metastasis formation in MSI-H CRC. [ABSTRACT FROM AUTHOR]

Published
2024
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