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4. Geographical distribution of invasive meningococcal disease and carriage: A spatial analysis.

Author

Milazzo, Adriana, McMillan, Mark, Giles, Lynne, Page, Kira, Flood, Louise, and Marshall, Helen

Abstract

Little information exists concerning the spatial relationship between invasive meningococcal disease (IMD) cases and Neisseria meningitidis (N. meningitidis) carriage. The aim of this study was to examine whether there is a relationship between IMD and asymptomatic oropharyngeal carriage of meningococci by spatial analysis to identify the distribution and patterns of cases and carriage in South Australia (SA). Carriage data geocoded to participants' residential addresses and meningococcal case notifications using Postal Area (POA) centroids were used to analyse spatial distribution by disease- and non-disease-associated genogroups, as well as overall from 2017 to 2020. The majority of IMD cases were genogroup B with the overall highest incidence of cases reported in infants, young children, and adolescents. We found no clear spatial association between N. meningitidis carriage and IMD cases. However, analyses using carriage and case genogroups showed differences in the spatial distribution between metropolitan and regional areas. Regional areas had a higher rate of IMD cases and carriage prevalence. While no clear relationship between cases and carriage was evident in the spatial analysis, the higher rates of both carriage and disease in regional areas highlight the need to maintain high vaccine coverage outside of the well-resourced metropolitan area. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Short Message Service Reminder Nudge for Parents and Influenza Vaccination Uptake in Children and Adolescents With Special Risk Medical Conditions

Author

Tuckerman, Jane, primary, Harper, Kelly, additional, Sullivan, Thomas R., additional, Cuthbert, Alana R., additional, Fereday, Jennifer, additional, Couper, Jennifer, additional, Smith, Nicholas, additional, Tai, Andrew, additional, Kelly, Andrew, additional, Couper, Richard, additional, Friswell, Mark, additional, Flood, Louise, additional, Blyth, Christopher C., additional, Danchin, Margie, additional, and Marshall, Helen S., additional

Published
2023
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6. Using provider–parent strategies to improve influenza vaccination in children and adolescents with special risk medical conditions: a randomised controlled trial protocol

Author

Tuckerman, Jane, primary, Harper, Kelly, additional, Sullivan, Thomas R, additional, Fereday, Jennifer, additional, Couper, Jennifer, additional, Smith, Nicholas, additional, Tai, Andrew, additional, Kelly, Andrew, additional, Couper, Richard, additional, Friswell, Mark, additional, Flood, Louise, additional, Danchin, Margaret, additional, Blyth, Christopher C, additional, and Marshall, Helen, additional

Published
2022
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8. Evaluating the effectiveness of the 4CMenB vaccine against invasive meningococcal disease and gonorrhoea in an infant, child and adolescent program: protocol

Author

Marshall, Helen S., primary, Andraweera, Prabha H., additional, Wang, Bing, additional, McMillan, Mark, additional, Koehler, Ann P., additional, Lally, Noel, additional, Almond, Sara, additional, Denehy, Emma, additional, A’Houre, Michele, additional, Giles, Lynne C., additional, and Flood, Louise, additional

Published
2021
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11. Epidemiology of basketball and netball injuries that resulted in hospital admission in Australia, 2000-2004

Author

Flood, Louise and Harrison, James E.

Subjects
Australia -- Health aspects, Sports injuries -- Physiological aspects, Sports injuries -- Care and treatment, Tendon injuries -- Care and treatment, Hospitals -- Admission and discharge, Hospitals -- Health aspects, Health
Abstract

The study identifies injuries sustained in basketball and netball that result in hospital admission and compares the profiles of injury between the two sports. Results reveal that the common injuries sustained in the two sports are age-related and that the long-term consequences of anterior cruciate ligament rupture and Achilles tendon injury requiring hospital admission have a significant impact on the individual and the community.

Published
2009

12. Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons

Author

Flood, Louise, Korol, Sergiy, Ekselius, Lisa, Birnir, Bryndis, and Jin, Zhe

Subjects
Interferon-gamma, Neurology, Neurologi, gamma-Aminobutyric acid, Hippocampus, Phasic inhibition, Tonic inhibition
Abstract

The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-gamma (IFN-gamma) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. However, the impact of IFN-gamma on the gamma-aminobutyric acid (GABA)-mediated currents in the hippocampus, a major brain region involved in the cognitive function, has not been investigated. Here we detected abundant expression of both IFN-gamma receptor subunit gene transcripts (Ifngrl and Ifngr2) in the rat hippocampus by quantitative PCR. In addition, we pre-incubated rat hippocampal slices with IFN-gamma (100 ng/ml) and recorded GABA-activated spontaneous and miniature postsynaptic inhibitory currents (sIPSCs and mIPSCs) and tonic currents in hippocampal CAl pyramidal neurons by the whole-cell patch-clamp method. The pre-incubation with IFN-gamma increased the frequency but not the mean amplitude, rise time or decay time of both sIPSCs and mIPSCs in hippocampal CAl pyramidal neurons, suggesting a presynaptic effect of IFN-gamma. Moreover, the GABA-activated tonic currents were enhanced by IFN-gamma. In conclusion, the potentiation of GABAergic currents in hippocampal neurons by IFN-gamma may contribute to the disturbed neuronal excitability and cognitive dysfunction during neuroinflammation.

Published
2019

13. An outbreak and case-control study of Salmonella Havana linked to alfalfa sprouts in South Australia, 2018

Author

Harfield, Stephen, Beazley, Rebecca, Denehy, Emma, Centofanti, Alessia, Dowsett, Paul, Housen, Tambri, Flood, Louise, Harfield, Stephen, Beazley, Rebecca, Denehy, Emma, Centofanti, Alessia, Dowsett, Paul, Housen, Tambri, and Flood, Louise

Abstract

An epidemiological investigation and a retrospective case-control study were conducted into an outbreak of Salmonella Havana in alfalfa sprouts, in Adelaide, Australia. In total, 31 cases of S. Havana were notified during June and July 2018 and linked to the outbreak. Eighteen cases and 54 unmatched controls were included in a case-control study. Results from the case-control study indicated an increased risk of illness linked to the consumption of alfalfa sprouts; this was supported by trace-back, sampling and environmental investigations. This outbreak of S. Havana was caused by consumption of alfalfa sprouts from one local sprouts producer. It is unclear as to when in the production of alfalfa sprouts the contamination occurred. However, contaminated seeds and poor pest control are the most likely causes. This investigation highlights the importance of ensuring that producers take appropriate action to minimise the likelihood of contamination and to comply with legislation and standards for primary production and food safety.

Published
2019

17. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010

Author

Salomon, Joshua A, primary, Vos, Theo, additional, Hogan, Daniel R, additional, Gagnon, Michael, additional, Naghavi, Mohsen, additional, Mokdad, Ali, additional, Begum, Nazma, additional, Shah, Razibuzzaman, additional, Karyana, Muhammad, additional, Kosen, Soewarta, additional, Farje, Mario Reyna, additional, Moncada, Gilberto, additional, Dutta, Arup, additional, Sazawal, Sunil, additional, Dyer, Andrew, additional, Seiler, Jason, additional, Aboyans, Victor, additional, Baker, Lesley, additional, Baxter, Amanda, additional, Benjamin, Emelia J, additional, Bhalla, Kavi, additional, Abdulhak, Aref Bin, additional, Blyth, Fiona, additional, Bourne, Rupert, additional, Braithwaite, Tasanee, additional, Brooks, Peter, additional, Brugha, Traolach S, additional, Bryan-Hancock, Claire, additional, Buchbinder, Rachelle, additional, Burney, Peter, additional, Calabria, Bianca, additional, Chen, Honglei, additional, Chugh, Sumeet S, additional, Cooley, Rebecca, additional, Criqui, Michael H, additional, Cross, Marita, additional, Dabhadkar, Kaustubh C, additional, Dahodwala, Nabila, additional, Davis, Adrian, additional, Degenhardt, Louisa, additional, Díaz-Torné, Cesar, additional, Dorsey, E Ray, additional, Driscoll, Tim, additional, Edmond, Karen, additional, Elbaz, Alexis, additional, Ezzati, Majid, additional, Feigin, Valery, additional, Ferri, Cleusa P, additional, Flaxman, Abraham D, additional, Flood, Louise, additional, Fransen, Marlene, additional, Fuse, Kana, additional, Gabbe, Belinda J, additional, Gillum, Richard F, additional, Haagsma, Juanita, additional, Harrison, James E, additional, Havmoeller, Rasmus, additional, Hay, Roderick J, additional, Hel-Baqui, Abdullah, additional, Hoek, Hans W, additional, Hoffman, Howard, additional, Hogeland, Emily, additional, Hoy, Damian, additional, Jarvis, Deborah, additional, Jonas, Jost B, additional, Karthikeyan, Ganesan, additional, Knowlton, Lisa Marie, additional, Lathlean, Tim, additional, Leasher, Janet L, additional, Lim, Stephen S, additional, Lipshultz, Steven E, additional, Lopez, Alan D, additional, Lozano, Rafael, additional, Lyons, Ronan, additional, Malekzadeh, Reza, additional, Marcenes, Wagner, additional, March, Lyn, additional, Margolis, David J, additional, McGill, Neil, additional, McGrath, John, additional, Mensah, George A, additional, Meyer, Ana-Claire, additional, Michaud, Catherine, additional, Moran, Andrew, additional, Mori, Rintaro, additional, Murdoch, Michele E, additional, Naldi, Luigi, additional, Newton, Charles R, additional, Norman, Rosana, additional, Omer, Saad B, additional, Osborne, Richard, additional, Pearce, Neil, additional, Perez-Ruiz, Fernando, additional, Perico, Norberto, additional, Pesudovs, Konrad, additional, Phillips, David, additional, Pourmalek, Farshad, additional, Prince, Martin, additional, Rehm, Jürgen T, additional, Remuzzi, Guiseppe, additional, Richardson, Kathryn, additional, Room, Robin, additional, Saha, Sukanta, additional, Sampson, Uchechukwu, additional, Sanchez-Riera, Lidia, additional, Segui-Gomez, Maria, additional, Shahraz, Saeid, additional, Shibuya, Kenji, additional, Singh, David, additional, Sliwa, Karen, additional, Smith, Emma, additional, Soerjomataram, Isabelle, additional, Steiner, Timothy, additional, Stolk, Wilma A, additional, Stovner, Lars Jacob, additional, Sudfeld, Christopher, additional, Taylor, Hugh R, additional, Tleyjeh, Imad M, additional, van der Werf, Marieke J, additional, Watson, Wendy L, additional, Weatherall, David J, additional, Weintraub, Robert, additional, Weisskopf, Marc G, additional, Whiteford, Harvey, additional, Wilkinson, James D, additional, Woolf, Anthony D, additional, Zheng, Zhi-Jie, additional, and Murray, Christopher JL, additional

Published
2012
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18. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Murray, Christopher J L, primary, Vos, Theo, additional, Lozano, Rafael, additional, Naghavi, Mohsen, additional, Flaxman, Abraham D, additional, Michaud, Catherine, additional, Ezzati, Majid, additional, Shibuya, Kenji, additional, Salomon, Joshua A, additional, Abdalla, Safa, additional, Aboyans, Victor, additional, Abraham, Jerry, additional, Ackerman, Ilana, additional, Aggarwal, Rakesh, additional, Ahn, Stephanie Y, additional, Ali, Mohammed K, additional, AlMazroa, Mohammad A, additional, Alvarado, Miriam, additional, Anderson, H Ross, additional, Anderson, Laurie M, additional, Andrews, Kathryn G, additional, Atkinson, Charles, additional, Baddour, Larry M, additional, Bahalim, Adil N, additional, Barker-Collo, Suzanne, additional, Barrero, Lope H, additional, Bartels, David H, additional, Basáñez, Maria-Gloria, additional, Baxter, Amanda, additional, Bell, Michelle L, additional, Benjamin, Emelia J, additional, Bennett, Derrick, additional, Bernabé, Eduardo, additional, Bhalla, Kavi, additional, Bhandari, Bishal, additional, Bikbov, Boris, additional, Abdulhak, Aref Bin, additional, Birbeck, Gretchen, additional, Black, James A, additional, Blencowe, Hannah, additional, Blore, Jed D, additional, Blyth, Fiona, additional, Bolliger, Ian, additional, Bonaventure, Audrey, additional, Boufous, Soufiane, additional, Bourne, Rupert, additional, Boussinesq, Michel, additional, Braithwaite, Tasanee, additional, Brayne, Carol, additional, Bridgett, Lisa, additional, Brooker, Simon, additional, Brooks, Peter, additional, Brugha, Traolach S, additional, Bryan-Hancock, Claire, additional, Bucello, Chiara, additional, Buchbinder, Rachelle, additional, Buckle, Geoffrey, additional, Budke, Christine M, additional, Burch, Michael, additional, Burney, Peter, additional, Burstein, Roy, additional, Calabria, Bianca, additional, Campbell, Benjamin, additional, Canter, Charles E, additional, Carabin, Hélène, additional, Carapetis, Jonathan, additional, Carmona, Loreto, additional, Cella, Claudia, additional, Charlson, Fiona, additional, Chen, Honglei, additional, Cheng, Andrew Tai-Ann, additional, Chou, David, additional, Chugh, Sumeet S, additional, Coffeng, Luc E, additional, Colan, Steven D, additional, Colquhoun, Samantha, additional, Colson, K Ellicott, additional, Condon, John, additional, Connor, Myles D, additional, Cooper, Leslie T, additional, Corriere, Matthew, additional, Cortinovis, Monica, additional, de Vaccaro, Karen Courville, additional, Couser, William, additional, Cowie, Benjamin C, additional, Criqui, Michael H, additional, Cross, Marita, additional, Dabhadkar, Kaustubh C, additional, Dahiya, Manu, additional, Dahodwala, Nabila, additional, Damsere-Derry, James, additional, Danaei, Goodarz, additional, Davis, Adrian, additional, Leo, Diego De, additional, Degenhardt, Louisa, additional, Dellavalle, Robert, additional, Delossantos, Allyne, additional, Denenberg, Julie, additional, Derrett, Sarah, additional, Des Jarlais, Don C, additional, Dharmaratne, Samath D, additional, Dherani, Mukesh, additional, Diaz-Torne, Cesar, additional, Dolk, Helen, additional, Dorsey, E Ray, additional, Driscoll, Tim, additional, Duber, Herbert, additional, Ebel, Beth, additional, Edmond, Karen, additional, Elbaz, Alexis, additional, Ali, Suad Eltahir, additional, Erskine, Holly, additional, Erwin, Patricia J, additional, Espindola, Patricia, additional, Ewoigbokhan, Stalin E, additional, Farzadfar, Farshad, additional, Feigin, Valery, additional, Felson, David T, additional, Ferrari, Alize, additional, Ferri, Cleusa P, additional, Fèvre, Eric M, additional, Finucane, Mariel M, additional, Flaxman, Seth, additional, Flood, Louise, additional, Foreman, Kyle, additional, Forouzanfar, Mohammad H, additional, Fowkes, Francis Gerry R, additional, Fransen, Marlene, additional, Freeman, Michael K, additional, Gabbe, Belinda J, additional, Gabriel, Sherine E, additional, Gakidou, Emmanuela, additional, Ganatra, Hammad A, additional, Garcia, Bianca, additional, Gaspari, Flavio, additional, Gillum, Richard F, additional, Gmel, Gerhard, additional, Gonzalez-Medina, Diego, additional, Gosselin, Richard, additional, Grainger, Rebecca, additional, Grant, Bridget, additional, Groeger, Justina, additional, Guillemin, Francis, additional, Gunnell, David, additional, Gupta, Ramyani, additional, Haagsma, Juanita, additional, Hagan, Holly, additional, Halasa, Yara A, additional, Hall, Wayne, additional, Haring, Diana, additional, Haro, Josep Maria, additional, Harrison, James E, additional, Havmoeller, Rasmus, additional, Hay, Roderick J, additional, Higashi, Hideki, additional, Hill, Catherine, additional, Hoen, Bruno, additional, Hoffman, Howard, additional, Hotez, Peter J, additional, Hoy, Damian, additional, Huang, John J, additional, Ibeanusi, Sydney E, additional, Jacobsen, Kathryn H, additional, James, Spencer L, additional, Jarvis, Deborah, additional, Jasrasaria, Rashmi, additional, Jayaraman, Sudha, additional, Johns, Nicole, additional, Jonas, Jost B, additional, Karthikeyan, Ganesan, additional, Kassebaum, Nicholas, additional, Kawakami, Norito, additional, Keren, Andre, additional, Khoo, Jon-Paul, additional, King, Charles H, additional, Knowlton, Lisa Marie, additional, Kobusingye, Olive, additional, Koranteng, Adofo, additional, Krishnamurthi, Rita, additional, Laden, Francine, additional, Lalloo, Ratilal, additional, Laslett, Laura L, additional, Lathlean, Tim, additional, Leasher, Janet L, additional, Lee, Yong Yi, additional, Leigh, James, additional, Levinson, Daphna, additional, Lim, Stephen S, additional, Limb, Elizabeth, additional, Lin, John Kent, additional, Lipnick, Michael, additional, Lipshultz, Steven E, additional, Liu, Wei, additional, Loane, Maria, additional, Ohno, Summer Lockett, additional, Lyons, Ronan, additional, Mabweijano, Jacqueline, additional, MacIntyre, Michael F, additional, Malekzadeh, Reza, additional, Mallinger, Leslie, additional, Manivannan, Sivabalan, additional, Marcenes, Wagner, additional, March, Lyn, additional, Margolis, David J, additional, Marks, Guy B, additional, Marks, Robin, additional, Matsumori, Akira, additional, Matzopoulos, Richard, additional, Mayosi, Bongani M, additional, McAnulty, John H, additional, McDermott, Mary M, additional, McGill, Neil, additional, McGrath, John, additional, Medina-Mora, Maria Elena, additional, Meltzer, Michele, additional, Memish, Ziad A, additional, Mensah, George A, additional, Merriman, Tony R, additional, Meyer, Ana-Claire, additional, Miglioli, Valeria, additional, Miller, Matthew, additional, Miller, Ted R, additional, Mitchell, Philip B, additional, Mock, Charles, additional, Mocumbi, Ana Olga, additional, Moffitt, Terrie E, additional, Mokdad, Ali A, additional, Monasta, Lorenzo, additional, Montico, Marcella, additional, Moradi-Lakeh, Maziar, additional, Moran, Andrew, additional, Morawska, Lidia, additional, Mori, Rintaro, additional, Murdoch, Michele E, additional, Mwaniki, Michael K, additional, Naidoo, Kovin, additional, Nair, M Nathan, additional, Naldi, Luigi, additional, Narayan, K M Venkat, additional, Nelson, Paul K, additional, Nelson, Robert G, additional, Nevitt, Michael C, additional, Newton, Charles R, additional, Nolte, Sandra, additional, Norman, Paul, additional, Norman, Rosana, additional, O'Donnell, Martin, additional, O'Hanlon, Simon, additional, Olives, Casey, additional, Omer, Saad B, additional, Ortblad, Katrina, additional, Osborne, Richard, additional, Ozgediz, Doruk, additional, Page, Andrew, additional, Pahari, Bishnu, additional, Pandian, Jeyaraj Durai, additional, Rivero, Andrea Panozo, additional, Patten, Scott B, additional, Pearce, Neil, additional, Padilla, Rogelio Perez, additional, Perez-Ruiz, Fernando, additional, Perico, Norberto, additional, Pesudovs, Konrad, additional, Phillips, David, additional, Phillips, Michael R, additional, Pierce, Kelsey, additional, Pion, Sébastien, additional, Polanczyk, Guilherme V, additional, Polinder, Suzanne, additional, Pope, C Arden, additional, Popova, Svetlana, additional, Porrini, Esteban, additional, Pourmalek, Farshad, additional, Prince, Martin, additional, Pullan, Rachel L, additional, Ramaiah, Kapa D, additional, Ranganathan, Dharani, additional, Razavi, Homie, additional, Regan, Mathilda, additional, Rehm, Jürgen T, additional, Rein, David B, additional, Remuzzi, Guiseppe, additional, Richardson, Kathryn, additional, Rivara, Frederick P, additional, Roberts, Thomas, additional, Robinson, Carolyn, additional, De Leòn, Felipe Rodriguez, additional, Ronfani, Luca, additional, Room, Robin, additional, Rosenfeld, Lisa C, additional, Rushton, Lesley, additional, Sacco, Ralph L, additional, Saha, Sukanta, additional, Sampson, Uchechukwu, additional, Sanchez-Riera, Lidia, additional, Sanman, Ella, additional, Schwebel, David C, additional, Scott, James Graham, additional, Segui-Gomez, Maria, additional, Shahraz, Saeid, additional, Shepard, Donald S, additional, Shin, Hwashin, additional, Shivakoti, Rupak, additional, Silberberg, Donald, additional, Singh, David, additional, Singh, Gitanjali M, additional, Singh, Jasvinder A, additional, Singleton, Jessica, additional, Sleet, David A, additional, Sliwa, Karen, additional, Smith, Emma, additional, Smith, Jennifer L, additional, Stapelberg, Nicolas JC, additional, Steer, Andrew, additional, Steiner, Timothy, additional, Stolk, Wilma A, additional, Stovner, Lars Jacob, additional, Sudfeld, Christopher, additional, Syed, Sana, additional, Tamburlini, Giorgio, additional, Tavakkoli, Mohammad, additional, Taylor, Hugh R, additional, Taylor, Jennifer A, additional, Taylor, William J, additional, Thomas, Bernadette, additional, Thomson, W Murray, additional, Thurston, George D, additional, Tleyjeh, Imad M, additional, Tonelli, Marcello, additional, Towbin, Jeffrey A, additional, Truelsen, Thomas, additional, Tsilimbaris, Miltiadis K, additional, Ubeda, Clotilde, additional, Undurraga, Eduardo A, additional, van der Werf, Marieke J, additional, van Os, Jim, additional, Vavilala, Monica S, additional, Venketasubramanian, N, additional, Wang, Mengru, additional, Wang, Wenzhi, additional, Watt, Kerrianne, additional, Weatherall, David J, additional, Weinstock, Martin A, additional, Weintraub, Robert, additional, Weisskopf, Marc G, additional, Weissman, Myrna M, additional, White, Richard A, additional, Whiteford, Harvey, additional, Wiebe, Natasha, additional, Wiersma, Steven T, additional, Wilkinson, James D, additional, Williams, Hywel C, additional, Williams, Sean RM, additional, Witt, Emma, additional, Wolfe, Frederick, additional, Woolf, Anthony D, additional, Wulf, Sarah, additional, Yeh, Pon-Hsiu, additional, Zaidi, Anita KM, additional, Zheng, Zhi-Jie, additional, Zonies, David, additional, and Lopez, Alan D, additional

Published
2012
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19. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Vos, Theo, primary, Flaxman, Abraham D, additional, Naghavi, Mohsen, additional, Lozano, Rafael, additional, Michaud, Catherine, additional, Ezzati, Majid, additional, Shibuya, Kenji, additional, Salomon, Joshua A, additional, Abdalla, Safa, additional, Aboyans, Victor, additional, Abraham, Jerry, additional, Ackerman, Ilana, additional, Aggarwal, Rakesh, additional, Ahn, Stephanie Y, additional, Ali, Mohammed K, additional, AlMazroa, Mohammad A, additional, Alvarado, Miriam, additional, Anderson, H Ross, additional, Anderson, Laurie M, additional, Andrews, Kathryn G, additional, Atkinson, Charles, additional, Baddour, Larry M, additional, Bahalim, Adil N, additional, Barker-Collo, Suzanne, additional, Barrero, Lope H, additional, Bartels, David H, additional, Basáñez, Maria-Gloria, additional, Baxter, Amanda, additional, Bell, Michelle L, additional, Benjamin, Emelia J, additional, Bennett, Derrick, additional, Bernabé, Eduardo, additional, Bhalla, Kavi, additional, Bhandari, Bishal, additional, Bikbov, Boris, additional, Abdulhak, Aref Bin, additional, Birbeck, Gretchen, additional, Black, James A, additional, Blencowe, Hannah, additional, Blore, Jed D, additional, Blyth, Fiona, additional, Bolliger, Ian, additional, Bonaventure, Audrey, additional, Boufous, Soufiane, additional, Bourne, Rupert, additional, Boussinesq, Michel, additional, Braithwaite, Tasanee, additional, Brayne, Carol, additional, Bridgett, Lisa, additional, Brooker, Simon, additional, Brooks, Peter, additional, Brugha, Traolach S, additional, Bryan-Hancock, Claire, additional, Bucello, Chiara, additional, Buchbinder, Rachelle, additional, Buckle, Geoffrey, additional, Budke, Christine M, additional, Burch, Michael, additional, Burney, Peter, additional, Burstein, Roy, additional, Calabria, Bianca, additional, Campbell, Benjamin, additional, Canter, Charles E, additional, Carabin, Hélène, additional, Carapetis, Jonathan, additional, Carmona, Loreto, additional, Cella, Claudia, additional, Charlson, Fiona, additional, Chen, Honglei, additional, Cheng, Andrew Tai-Ann, additional, Chou, David, additional, Chugh, Sumeet S, additional, Coffeng, Luc E, additional, Colan, Steven D, additional, Colquhoun, Samantha, additional, Colson, K Ellicott, additional, Condon, John, additional, Connor, Myles D, additional, Cooper, Leslie T, additional, Corriere, Matthew, additional, Cortinovis, Monica, additional, de Vaccaro, Karen Courville, additional, Couser, William, additional, Cowie, Benjamin C, additional, Criqui, Michael H, additional, Cross, Marita, additional, Dabhadkar, Kaustubh C, additional, Dahiya, Manu, additional, Dahodwala, Nabila, additional, Damsere-Derry, James, additional, Danaei, Goodarz, additional, Davis, Adrian, additional, De Leo, Diego, additional, Degenhardt, Louisa, additional, Dellavalle, Robert, additional, Delossantos, Allyne, additional, Denenberg, Julie, additional, Derrett, Sarah, additional, Des Jarlais, Don C, additional, Dharmaratne, Samath D, additional, Dherani, Mukesh, additional, Diaz-Torne, Cesar, additional, Dolk, Helen, additional, Dorsey, E Ray, additional, Driscoll, Tim, additional, Duber, Herbert, additional, Ebel, Beth, additional, Edmond, Karen, additional, Elbaz, Alexis, additional, Ali, Suad Eltahir, additional, Erskine, Holly, additional, Erwin, Patricia J, additional, Espindola, Patricia, additional, Ewoigbokhan, Stalin E, additional, Farzadfar, Farshad, additional, Feigin, Valery, additional, Felson, David T, additional, Ferrari, Alize, additional, Ferri, Cleusa P, additional, Fèvre, Eric M, additional, Finucane, Mariel M, additional, Flaxman, Seth, additional, Flood, Louise, additional, Foreman, Kyle, additional, Forouzanfar, Mohammad H, additional, Fowkes, Francis Gerry R, additional, Franklin, Richard, additional, Fransen, Marlene, additional, Freeman, Michael K, additional, Gabbe, Belinda J, additional, Gabriel, Sherine E, additional, Gakidou, Emmanuela, additional, Ganatra, Hammad A, additional, Garcia, Bianca, additional, Gaspari, Flavio, additional, Gillum, Richard F, additional, Gmel, Gerhard, additional, Gosselin, Richard, additional, Grainger, Rebecca, additional, Groeger, Justina, additional, Guillemin, Francis, additional, Gunnell, David, additional, Gupta, Ramyani, additional, Haagsma, Juanita, additional, Hagan, Holly, additional, Halasa, Yara A, additional, Hall, Wayne, additional, Haring, Diana, additional, Haro, Josep Maria, additional, Harrison, James E, additional, Havmoeller, Rasmus, additional, Hay, Roderick J, additional, Higashi, Hideki, additional, Hill, Catherine, additional, Hoen, Bruno, additional, Hoffman, Howard, additional, Hotez, Peter J, additional, Hoy, Damian, additional, Huang, John J, additional, Ibeanusi, Sydney E, additional, Jacobsen, Kathryn H, additional, James, Spencer L, additional, Jarvis, Deborah, additional, Jasrasaria, Rashmi, additional, Jayaraman, Sudha, additional, Johns, Nicole, additional, Jonas, Jost B, additional, Karthikeyan, Ganesan, additional, Kassebaum, Nicholas, additional, Kawakami, Norito, additional, Keren, Andre, additional, Khoo, Jon-Paul, additional, King, Charles H, additional, Knowlton, Lisa Marie, additional, Kobusingye, Olive, additional, Koranteng, Adofo, additional, Krishnamurthi, Rita, additional, Lalloo, Ratilal, additional, Laslett, Laura L, additional, Lathlean, Tim, additional, Leasher, Janet L, additional, Lee, Yong Yi, additional, Leigh, James, additional, Lim, Stephen S, additional, Limb, Elizabeth, additional, Lin, John Kent, additional, Lipnick, Michael, additional, Lipshultz, Steven E, additional, Liu, Wei, additional, Loane, Maria, additional, Ohno, Summer Lockett, additional, Lyons, Ronan, additional, Ma, Jixiang, additional, Mabweijano, Jacqueline, additional, MacIntyre, Michael F, additional, Malekzadeh, Reza, additional, Mallinger, Leslie, additional, Manivannan, Sivabalan, additional, Marcenes, Wagner, additional, March, Lyn, additional, Margolis, David J, additional, Marks, Guy B, additional, Marks, Robin, additional, Matsumori, Akira, additional, Matzopoulos, Richard, additional, Mayosi, Bongani M, additional, McAnulty, John H, additional, McDermott, Mary M, additional, McGill, Neil, additional, McGrath, John, additional, Medina-Mora, Maria Elena, additional, Meltzer, Michele, additional, Memish, Ziad A, additional, Mensah, George A, additional, Merriman, Tony R, additional, Meyer, Ana-Claire, additional, Miglioli, Valeria, additional, Miller, Matthew, additional, Miller, Ted R, additional, Mitchell, Philip B, additional, Mocumbi, Ana Olga, additional, Moffitt, Terrie E, additional, Mokdad, Ali A, additional, Monasta, Lorenzo, additional, Montico, Marcella, additional, Moradi-Lakeh, Maziar, additional, Moran, Andrew, additional, Morawska, Lidia, additional, Mori, Rintaro, additional, Murdoch, Michele E, additional, Mwaniki, Michael K, additional, Naidoo, Kovin, additional, Nair, M Nathan, additional, Naldi, Luigi, additional, Narayan, KM Venkat, additional, Nelson, Paul K, additional, Nelson, Robert G, additional, Nevitt, Michael C, additional, Newton, Charles R, additional, Nolte, Sandra, additional, Norman, Paul, additional, Norman, Rosana, additional, O'Donnell, Martin, additional, O'Hanlon, Simon, additional, Olives, Casey, additional, Omer, Saad B, additional, Ortblad, Katrina, additional, Osborne, Richard, additional, Ozgediz, Doruk, additional, Page, Andrew, additional, Pahari, Bishnu, additional, Pandian, Jeyaraj Durai, additional, Rivero, Andrea Panozo, additional, Patten, Scott B, additional, Pearce, Neil, additional, Padilla, Rogelio Perez, additional, Perez-Ruiz, Fernando, additional, Perico, Norberto, additional, Pesudovs, Konrad, additional, Phillips, David, additional, Phillips, Michael R, additional, Pierce, Kelsey, additional, Pion, Sébastien, additional, Polanczyk, Guilherme V, additional, Polinder, Suzanne, additional, Pope, C Arden, additional, Popova, Svetlana, additional, Porrini, Esteban, additional, Pourmalek, Farshad, additional, Prince, Martin, additional, Pullan, Rachel L, additional, Ramaiah, Kapa D, additional, Ranganathan, Dharani, additional, Razavi, Homie, additional, Regan, Mathilda, additional, Rehm, Jürgen T, additional, Rein, David B, additional, Remuzzi, Guiseppe, additional, Richardson, Kathryn, additional, Rivara, Frederick P, additional, Roberts, Thomas, additional, Robinson, Carolyn, additional, De Leòn, Felipe Rodriguez, additional, Ronfani, Luca, additional, Room, Robin, additional, Rosenfeld, Lisa C, additional, Rushton, Lesley, additional, Sacco, Ralph L, additional, Saha, Sukanta, additional, Sampson, Uchechukwu, additional, Sanchez-Riera, Lidia, additional, Sanman, Ella, additional, Schwebel, David C, additional, Scott, James Graham, additional, Segui-Gomez, Maria, additional, Shahraz, Saeid, additional, Shepard, Donald S, additional, Shin, Hwashin, additional, Shivakoti, Rupak, additional, Silberberg, Donald, additional, Singh, David, additional, Singh, Gitanjali M, additional, Singh, Jasvinder A, additional, Singleton, Jessica, additional, Sleet, David A, additional, Sliwa, Karen, additional, Smith, Emma, additional, Smith, Jennifer L, additional, Stapelberg, Nicolas JC, additional, Steer, Andrew, additional, Steiner, Timothy, additional, Stolk, Wilma A, additional, Stovner, Lars Jacob, additional, Sudfeld, Christopher, additional, Syed, Sana, additional, Tamburlini, Giorgio, additional, Tavakkoli, Mohammad, additional, Taylor, Hugh R, additional, Taylor, Jennifer A, additional, Taylor, William J, additional, Thomas, Bernadette, additional, Thomson, W Murray, additional, Thurston, George D, additional, Tleyjeh, Imad M, additional, Tonelli, Marcello, additional, Towbin, Jeffrey A, additional, Truelsen, Thomas, additional, Tsilimbaris, Miltiadis K, additional, Ubeda, Clotilde, additional, Undurraga, Eduardo A, additional, van der Werf, Marieke J, additional, van Os, Jim, additional, Vavilala, Monica S, additional, Venketasubramanian, N, additional, Wang, Mengru, additional, Wang, Wenzhi, additional, Watt, Kerrianne, additional, Weatherall, David J, additional, Weinstock, Martin A, additional, Weintraub, Robert, additional, Weisskopf, Marc G, additional, Weissman, Myrna M, additional, White, Richard A, additional, Whiteford, Harvey, additional, Wiersma, Steven T, additional, Wilkinson, James D, additional, Williams, Hywel C, additional, Williams, Sean RM, additional, Witt, Emma, additional, Wolfe, Frederick, additional, Woolf, Anthony D, additional, Wulf, Sarah, additional, Yeh, Pon-Hsiu, additional, Zaidi, Anita KM, additional, Zheng, Zhi-Jie, additional, Zonies, David, additional, Lopez, Alan D, additional, and Murray, Christopher JL, additional

Published
2012
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21. An increase in neural tube defect notifications, South Australia, 2009-2010.

Author

Flood, Louise, Scheil, Wendy, Nguyen, Anh-Minh, Sage, Leonie, and Scott, Joan

Subjects
NEURAL tube defects, CHILDBIRTH, STILLBIRTH, BIRTH weight, ABORTION, QUANTITATIVE research, CHI-squared test
Abstract

Introduction: In South Australia, reporting of live births, stillbirths of at least 20 weeks or 400g birth weight, termination of pregnancies and congenital anomalies is mandated. We describe the investigation of an increase in notifications of neural tube defects (NTDs) in South Australia in 2009 and 2010 using data from several surveillance systems. Methods: NTD trend data from 1966 to 2010 were reviewed. Comparisons of pregnancies affected by an NTD in 2009 and 2010 were made with pregnancies affected by an NTD in the period 2003-2008 and with all pregnancies in 2009 and 2010. Statistical analysis was undertaken using Poisson regression, chi-squared or Fisher's exact tests. Results: The prevalence of NTD-affected pregnancies was 1.95 per 1000 births (39 cases) in 2010 and 1.91 per 1000 births in 2009 (38 cases), the highest annual rates since 1991. Case series comparisons indicated women with NTD-affected pregnancies in 2009 and 2010 were less likely to be Caucasian compared with women who had NTD-affected pregnancies in the period 2003-2008. Women born in the Middle East and African region (n = 7) were significantly more likely to have NTD-affected pregnancies in the years 2009 and 2010 (relative risk: 3.03; 95% confidence interval: 1.39-6.62) compared with women born in the Oceania region. Discussion: The increased notifications of NTDs can only be partially explained by the increase in numbers of women from the Middle East and African region, with no other contributory causes revealed. This analysis highlighted areas where prevention efforts should be strengthened and surveillance data improved. [ABSTRACT FROM AUTHOR]

Published
2013
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24. Operative Techniques in the Fetal Rabbit

Author

Nelson, Jeffrey M., primary, Krummel, Thomas M., additional, Haynes, Jeffrey H., additional, Flood, Louise C., additional, Sauer, Loie, additional, Flake, Alan W., additional, and Harrison, Michael R., additional

Published
1990
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25. Fetal Skin Organ Culture

Author

Haynes, Jeffrey H., primary, Krummel, Thomas M., additional, Flood, Louise C., additional, Cohen, I. Kelman, additional, and Diegelmann, Robert F., additional

Published
1990
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26. Using provider–parent strategies to improve influenza vaccination in children and adolescents with special risk medical conditions: a randomised controlled trial protocol

Author

Jane Tuckerman, Kelly Harper, Thomas R Sullivan, Jennifer Fereday, Jennifer Couper, Nicholas Smith, Andrew Tai, Andrew Kelly, Richard Couper, Mark Friswell, Louise Flood, Margaret Danchin, Christopher C Blyth, Helen Marshall, Tuckerman, Jane, Harper, Kelly, Sullivan, Thomas R, Fereday, Jennifer, Couper, Jennifer, Smith, Nicholas, Tai, Andrew, Kelly, Andrew, Couper, Richard, Friswell, Mark, Flood, Louise, Danchin, Margaret, Blyth, Christopher C, and Marshall, Helen

Subjects
Parents, protocols & guidelines, Adolescent, public health, Vaccination, Australia, Child Health, General Medicine, paediatric infectious disease & immunisation, preventive medicine, Influenza, Human, Medicine, Humans, Women's Health, Female, Child, Randomized Controlled Trials as Topic
Abstract

IntroductionInfluenza immunisation is a highly cost-effective public health intervention. Despite a comprehensive National Immunisation Program, influenza vaccination in children and adolescents with special risk medical conditions (SRMCs) is suboptimal. Flutext-4U is an innovative, multi-component strategy targeting paediatric hospitals, general practice and parents of children and adolescents with SRMC. The Flutext-4U study aims to assess the impact of Flutext-4U to increase influenza immunisation in children and adolescents with SRMC.Methods and analysisThis is a randomised controlled trial involving parents of children and adolescents (aged >6 months to Parents (of children/adolescents with SRMC) are randomised (1:1 ratio) to standard care plus intervention (SMS reminder messages to parents; reminders (written correspondence) for their child’s GP from the hospital’s Paediatric Outpatients Department) or standard care (hospital vaccine availability, ease of access and reminders for WCH subspecialists) with randomisation stratified by age-group (14 to The primary outcome is influenza vaccination, as confirmed by the Australian Immunisation Register.The proportion vaccinated (primary outcome) will be compared between randomised groups using logistic regression, with adjustment made for age group at randomisation. The effect of treatment will be described using an OR with a 95% CI.Ethics and disseminationThe protocol and all study materials have been reviewed and approved by the Women’s and Children’s Health Network Human Research Ethics Committee (HREC/20/WCHN/5). Results will be disseminated via peer-reviewed publication and at scientific meetings, professional and public forums.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12621000463875).

Published
2022

27. Comprehensive observational study evaluating the enduring effectiveness of 4CMenB, the meningococcal B vaccine against gonococcal infections in the Northern Territory and South Australia, Australia: study protocol.

Author

Marshall H, Ward J, Wang B, Andraweera P, McMillan M, Flood L, Bell C, Sisnowski J, Krause V, Webby R, Childs E, Gunathilake M, Egoroff N, Leong L, Lawrence A, Baird R, Freeman K, Menouhos D, Whiley DM, Karnon J, van Hal S, and Lahra MM

Subjects
Humans, Northern Territory epidemiology, South Australia epidemiology, Observational Studies as Topic, Female, Gonorrhea prevention & control, Gonorrhea epidemiology, Meningococcal Vaccines administration & dosage, Meningococcal Vaccines therapeutic use, Neisseria gonorrhoeae immunology
Abstract

Introduction: The effectiveness of antibiotics for treating gonococcal infections is compromised due to escalating antibiotic resistance; and the development of an effective gonococcal vaccine has been challenging. Emerging evidence suggests that the licensed meningococcal B (MenB) vaccine, 4CMenB is effective against gonococcal infections due to cross-reacting antibodies and 95% genetic homology between the two bacteria, Neisseria meningitidis and Neisseria gonorrhoeae, that cause the diseases. This project aims to undertake epidemiological and genomic surveillance to evaluate the long-term protection of the 4CMenB vaccine against gonococcal infections in the Northern Territory (NT) and South Australia (SA), and to determine the potential benefit of a booster vaccine doses to provide longer-term protection against gonococcal infections., Methods and Analyses: This observational study will provide long-term evaluation results of the effectiveness of the 4CMenB vaccine against gonococcal infections at 4-7 years post 4CMenB programme implementation. Routine notifiable disease notifications will be the basis for assessing the impact of the vaccine on gonococcal infections. Pathology laboratories will provide data on the number and percentage of N. gonorrhoeae positive tests relative to all tests administered and will coordinate molecular sequencing for isolates. Genome sequencing results will be provided by SA Pathology and Territory Pathology/New South Wales Health Pathology, and linked with notification data by SA Health and NT Health. There are limitations in observational studies including the potential for confounding. Confounders will be analysed separately for each outcome/comparison., Ethics and Dissemination: The protocol and all study documents have been reviewed and approved by the SA Department for Health and Well-being Human Research Ethics Committee (HREC/2022/HRE00308), and the evaluation will commence in the NT on receipt of approval from the NT Health and Menzies School of Health Research Human Research Ethics Committee. Results will be published in peer-reviewed journals and presented at scientific meetings and public forums., Competing Interests: Competing interests: HM acknowledges support from the National Health and Medical Research Council of Australia: Practitioner Fellowship (APP1155066). HM is an independent investigator on clinical trials of investigational vaccines manufactured by pharmaceutical companies including Pfizer, ILiAD Biotechnologies and Merck. The institution at which HM, BW, MM and PA are employed has received funding for investigator-led research from GlaxoSmithKline, Sanofi-Pasteur and Pfizer Vaccines. All authors receive no personal payments from the industry. There are no other conflicts of interest to declare., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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28. Interferon-γ potentiates GABA A receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons.

Author

Flood L, Korol SV, Ekselius L, Birnir B, and Jin Z

Subjects
Animals, CA1 Region, Hippocampal drug effects, GABA-A Receptor Antagonists pharmacology, Hippocampus cytology, Hippocampus drug effects, Inhibitory Postsynaptic Potentials drug effects, Inhibitory Postsynaptic Potentials physiology, Male, Neural Inhibition drug effects, Organ Culture Techniques, Pyramidal Cells drug effects, Rats, Rats, Wistar, CA1 Region, Hippocampal physiology, Hippocampus physiology, Interferon-gamma pharmacology, Neural Inhibition physiology, Pyramidal Cells physiology, Receptors, GABA-A physiology
Abstract

The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. However, the impact of IFN-γ on the γ-aminobutyric acid (GABA)-mediated currents in the hippocampus, a major brain region involved in the cognitive function, has not been investigated. Here we detected abundant expression of both IFN-γ receptor subunit gene transcripts (Ifngr1 and Ifngr2) in the rat hippocampus by quantitative PCR. In addition, we pre-incubated rat hippocampal slices with IFN-γ (100 ng/ml) and recorded GABA-activated spontaneous and miniature postsynaptic inhibitory currents (sIPSCs and mIPSCs) and tonic currents in hippocampal CA1 pyramidal neurons by the whole-cell patch-clamp method. The pre-incubation with IFN-γ increased the frequency but not the mean amplitude, rise time or decay time of both sIPSCs and mIPSCs in hippocampal CA1 pyramidal neurons, suggesting a presynaptic effect of IFN-γ. Moreover, the GABA-activated tonic currents were enhanced by IFN-γ. In conclusion, the potentiation of GABAergic currents in hippocampal neurons by IFN-γ may contribute to the disturbed neuronal excitability and cognitive dysfunction during neuroinflammation., (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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29. Influenza B outbreak in a primary school in Adelaide, Australia, 2011.

Author

Flood L, Raupach J, D'Onise K, and Russo D

Abstract

Introduction: This report describes a 2011 seasonal influenza B outbreak in a metropolitan primary school in Australia with 179 students., Methods: Epidemiological, microbiological and environmental investigations were undertaken. A retrospective cohort study was conducted using a questionnaire that included demographic data, details of illness, chronic health conditions and vaccination status. Influenza-like illness (ILI) was defined as fever plus cough and/or sore throat. Analysis of ILI was undertaken with the χ(2) test and Fisher's exact test., Results: Seventy-two questionnaire respondents (75%) reported illness during the outbreak - 43 with ILI, giving an attack rate of 45%. There was no association between ILI and age or chronic lung disease. Six (6%) students were vaccinated against influenza before the outbreak; although four became ill, none satisfied the ILI case definition. Seven students were positive for influenza B including two confirmed as B/Brisbane/60/2008-like; one student was positive for rhinovirus and another for metapneumovirus. The recommended influenza vaccine matched the circulating influenza strains., Discussion: This cohort study estimated a high ILI attack rate and demonstrated low influenza vaccine coverage within the setting of a primary school. Gastrointestinal symptoms, in addition to constitutional and respiratory symptoms, were common.

Published
2012
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