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6. Évaluation d’un questionnaire de sévérité au cours du pemphigus

Author

Pinard, C., primary, Duvert-Lehembre, S., additional, Prost-Squarcioni, C., additional, Alsubaiei, F., additional, Houivet, E., additional, Le Henaff, Y., additional, Heas, S., additional, Picard-Dahan, C., additional, Bernard, P., additional, Doutre, M.S., additional, Beylot-Barry, M., additional, Richard, M.-A., additional, Delaporte, E., additional, Fleuret, C., additional, Oro, S., additional, D’Incan, M., additional, Alexandre, M., additional, Caux, F., additional, Maillard, H., additional, Bénéton, N., additional, Hebert, V., additional, and Joly, P., additional

Published
2019
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9. Mortalité du pemphigus et facteurs pronostiques, incluant les traitements initialement proposés

Author

Jelti, L., primary, Cordel, N., additional, Gillibert, A., additional, Lacour, J.-P., additional, Uthurriague, C., additional, Doutre, M.-S., additional, Delaporte, E., additional, Duvert-Lehembre, S., additional, Quereux, G., additional, Dupuy, A., additional, Adamski, H., additional, Bedane, C., additional, Misery, L., additional, Abasq Thomas, C., additional, Fleuret, C., additional, Bernard, P., additional, Chaby, G., additional, D’incan, M., additional, Verneuil, L., additional, Litrowski, N., additional, and Joly, P., additional

Published
2018
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10. FEPSAC position statement : Mental health disorders in elite athletes and models of service provision

Author

Moesch, Karin, Kenttä, G., Kleinert, J., Quignon-Fleuret, C., Cecil, S., Bertollo, M., Moesch, Karin, Kenttä, G., Kleinert, J., Quignon-Fleuret, C., Cecil, S., and Bertollo, M.

Abstract

Mental health disorders (MHD) in elite athletes is a topic that has received increased attention in recent years. The overall aim of this position statement is to enhance awareness of this important topic and to critically discuss optimal service provision for athletes who suffer from MHD. In the first part of the paper a short overview of the research on MHD in elite athletes is provided. Elite athletes seem to have comparable prevalence rates for the most common MHD when compared to non-athletic peers, but there are still many disorders that have not been investigated in athletes. Sport specific situations such as injuries, periods of overtraining and career termination may put athletes at an increased risk of developing MHD. In the second part of the paper, models of service provision for elite athletes suffering from MHD from six European countries are presented, focusing on 1) professional service providers, 2) support systems, 3) diagnostic assessment, 4) clinical treatment, 5) performance during treatment, 6) screening, and 7) education systems. It emerges that competencies, certification issues, and professional boundaries of the involved service providers, as well as the structure of the National Health Care systems differ strongly across European countries, which makes defining a golden standard difficult. In the third part of this paper, the authors provide general recommendations for athletes and coaches, clubs, federations, organizations and scholars that hopefully will inspire stakeholders to optimize their support systems. © 2018

Published
2018
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18. Incidence et mortalité du pemphigus en France

Author

Jelti, L., primary, Le Bourhis-Zaimi, M., additional, Lacour, J.-P., additional, Uthurriague, C., additional, Doutre, M.-S., additional, Delaporte, E., additional, Duvert-Lehembre, S., additional, Quereux, G., additional, Dupuy, A., additional, Adamski, H., additional, Bedane, C., additional, Misery, L., additional, Abasq Thomas, C., additional, Fleuret, C., additional, Bernard, P., additional, Chaby, G., additional, D’incan, M., additional, Verneuil, L., additional, Litrowski, N., additional, and Joly, P., additional

Published
2016
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22. Traitements systémiques du psoriasis de l’enfant : étude multicentrique nationale chez 140 enfants

Author

Charbit, L., primary, Mahe, E., additional, Phan, A., additional, Droitcourt, C., additional, Boralevi, F., additional, Puzenat, E., additional, Abasq, C., additional, Aubert, H., additional, Barbarot, S., additional, Avenel-Audran, M., additional, Rodriguez, L., additional, Begon, E., additional, Mallet, S., additional, Balguerie, X., additional, Aubin, F., additional, Piram, M., additional, Souillet, A.-L., additional, Maruani, A., additional, Plantin, P., additional, Bourrat, E., additional, Lacour, J.-P., additional, Chiaverini, C., additional, Mazereeuw-Hautier, J., additional, Labreze, C., additional, Lasek, A., additional, Fleuret, C., additional, Kupfer, I., additional, Hadj-Rabia, S., additional, and Bursztejn, A.-C., additional

Published
2014
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41. Ischemic Digital Ulcers Affect Hand Disability and Pain in Systemic Sclerosis

Author

Mouthon, Luc, Carpentier, Patrick H., Lok, Catherine, Clerson, Pierre, Gressin, Virginie, Hachulla, Eric, Bérezné, Alice, Diot, Elisabeth, Khau Van Kien, Aurélie, Jego, Patrick, Agard, Christian, Duval-Modeste, Anne Bénédicte, Sparsa, Agnès, Puzenat, Eve, Richard, Marie-Aleth, Lok, C, Thuillier, D, Le Clec’h, C, Duchêne, F, Puzenat, E, Prey, S, Solanilla, A, Bourgault-Villada, I, Boulogne, Le Hello, C, Bienvenu, B, Berthier, S, Muller, G, Remond, B, Carpentier, P, Damade, R, Beneton-Benhard, N, Maillard, H, Barcat, D, Hachulla, E, Hatron, PY, Sparsa, A, Doffoel-Hantz, V, Fauchais, AL, Geffray, L, Coppéré, B, Jullien, D, Granier, F, Harle, JR, Granel, B, Richard, MA, Maurier, F, Cohen, JD, Khau Van Kien, A, Granel-Brocard, F, Agard, C, Queyrel, V, Corondan, A, Bérezné, A, Mouthon, L, Crickx, B, Picard Dahan, C, Eguia, B, Francès, C, Emmerich, J, Fiessinger, JN, Mathian, A, Lazareth, I, Michon-Pasturel, U, Viallard, JF, Wierzbicka-Hainaut, E, Fleuret, C, Léonard-Lefèbvre, F, Reguiai, Z, Jego, P, Perdriger, A, Modeste Duval, AB, Bonnin, A, Chatelus, E, Poindron, V, Diot, E, Bica-Chicinas, D, Roger, M, Wahl, D, and Zuily, S

Abstract

Objective.Ischemic digital ulcers (DU) are frequent and severe complications of systemic sclerosis (SSc). The purpose of our study was to assess the effect of DU on hand disability and pain in patients with SSc.Methods.The Evaluation of the Impact of Recurrent Ischemic DU on Hand Disability in Patients with SSc (ECLIPSE) is a prospective, multicenter, noninterventional study with a 2-year followup. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan therapy were included between October 2009 and March 2011. This cohort is described at the time of inclusion.Results.There were 190 patients (132 females) from 53 centers. Mean age ± SD was 43 ± 15 years at SSc diagnosis and 53 ± 15 years at inclusion. In 105 patients (56.2%), DU were the first non-Raynaud symptoms of SSc. The mean time interval between the occurrence of Raynaud phenomenon and the first DU episode was 6.6 ± 9.1 years. The mean numbers of active DU and fingers affected per patient for both hands were 2.3 ± 1.8 and 2.2 ± 1.6, respectively. Presence of active DU at inclusion was significantly associated with pain and impaired hand function: Visual Analog Scale for pain (0 to 10) was 6.2 ± 2.6 versus 2.5 ± 2.4 (p < 0.0001) and Cochin Hand Function Scale for hand disability (0 to 90) was 38 ± 20 versus 25 ± 19 (p < 0.0001), respectively.Conclusion.DU represent a major sign of SSc, often affecting multiple fingers and both hands. They are significantly associated with pain and hand disability.

Published
2014
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45. Infection cutanéo-muqueuse disséminée à Acanthamoebachez une patiente immunodéprimée

Author

Clerc, C.-J., Talarmin, J.-P., Chrétien, F., Staroz, F., Yera, H., Plantin, P., Fleuret, C., and Acquitter, M.

Abstract

Acanthamoebaest une amibe, fréquemment retrouvée dans l’environnement. Ce protozoaire est rarement responsable de kératite et d’encéphalite chez des patients immunodéprimés. L’atteinte cutanéo-muqueuse est exceptionnelle.

Published
2015
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46. Bile Acid Malabsorption as a Consequence of Cancer Treatment: Prevalence and Management in the National Leading Centre.

Author

Gee C, Fleuret C, Wilson A, Levine D, Elhusseiny R, Muls A, Cunningham D, and Kohoutova D

Abstract

The aim was to establish prevalence of bile acid malabsorption (BAM) and management in patients who underwent treatment for malignancy. Retrospective evaluation of data in patients seen within six months (August 2019-January 2020) was carried out. Demographic, nuclear medicine (Selenium Homocholic Acid Taurine (SeHCAT) scan result), clinical (previous malignancy, type of intervention (medication, diet), response to intervention) and laboratory (vitamin D, vitamin B12 serum levels) data were searched. In total, 265 consecutive patients were reviewed. Out of those, 87/265 (33%) patients (57 females, 66%) were diagnosed with BAM. Mean age was 59 +/- 12 years. The largest group were females with gynaecological cancer (35), followed by haematology group (15), colorectal/anal (13), prostate (9), upper gastrointestinal cancer (6), another previous malignancy (9). Severe BAM was most common in haematology (10/15; 67%) and gynaecological group (21/35; 60%). Medication and low-fat diet were commenced in 65/87 (75%), medication in 10/87 (11%), diet in 6/87 (7%). Colesevelam was used in 71/75 (95%). Symptoms improved in 74/87 (85%) patients. Vitamin D insufficiency/deficiency was diagnosed in 62/87 (71%), vitamin B12 deficiency in 39/87 (45%). BAM is a common condition in this cohort however treatments are highly effective.

Published
2021
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47. [Erlotinib-induced scarring alopecia with a folliculitis decalvans-like presentation].

Author

Dervout C, Chiappa AM, Fleuret C, Plantin P, and Acquitter M

Subjects
Alopecia chemically induced, Erlotinib Hydrochloride adverse effects, Erythema, Female, Humans, Middle Aged, Neoplasm Recurrence, Local, Cicatrix chemically induced, Folliculitis chemically induced
Abstract

Background: Epidermal growth factor receptor (EGFR) inhibitors are targeted therapies that frequently induce skin eruptions such as acneiform rash. Due to their increasing use in oncology as well as the expanding number of exposed patients, new adverse events may emerge., Patients and Methods: A 54-year-old female patient treated with erlotinib for 8 months for pulmonary adenocarcinoma presented inflammatory alopecia that had been ongoing for 1 month. Her condition did not improve with doxycycline 100mg/day. Diffuse erythema of the scalp was associated with painful keratotic plaques and several oozing lesions. A skin biopsy showed signs of acute suppurative and destructive folliculitis. Histology and dermatoscopy were consistent with a diagnosis of folliculitis decalvans. Marked improvement was observed after discontinuation of erlotinib followed by introduction of amoxicillin+clavulanic acid and application of a topical corticosteroid. Unfortunately, the lesions recurred after reintroduction of the anti-EGFR, despite a dosage reduction, requiring up-titration of doxycycline to 200mg/day., Discussion: Scarring alopecia with a folliculitis decalvans-like presentation secondary to anti-EGFR is a rare adverse event. The exact pathophysiology remains poorly understood. Treatment is difficult, and while systemic antibiotics are effective, they must be maintained for a long duration in order to avoid recurrence. Early recognition is important to limit the development of scarring alopecia due to the difficulties of stopping treatment in advanced-stage carcinoma., (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)

Published
2020
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48. Incidence and Mortality of Pemphigus in France.

Author

Jelti L, Cordel N, Gillibert A, Lacour JP, Uthurriague C, Doutre MS, Delaporte E, Duvert-Lehembre S, Quereux G, Dupuy A, Adamski H, Bedane C, Misery L, Abasq Thomas C, Fleuret C, Bernard P, Chaby G, D'incan M, Verneuil L, Litrowski N, and Joly P

Subjects
Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, France epidemiology, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Mortality trends, Prognosis, Sex Factors, Young Adult, Pemphigus epidemiology
Published
2019
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49. [An unusual presentation of mantle cell lymphoma].

Author

Orgeolet L, Staroz F, Acquitter M, Plantin P, and Fleuret C

Subjects
Aged, Antigens, CD analysis, B-Lymphocytes pathology, Cheilitis pathology, Diagnosis, Differential, Facial Dermatoses pathology, Humans, Immunophenotyping, Lyme Disease diagnosis, Lymphoma, Mantle-Cell complications, Macroglossia pathology, Male, Melkersson-Rosenthal Syndrome diagnosis, Pseudolymphoma diagnosis, Sarcoidosis diagnosis, Syphilis diagnosis, Cheilitis etiology, Facial Dermatoses etiology, Lymphoma, Mantle-Cell diagnosis, Macroglossia etiology
Published
2018
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