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46 results on '"Fletcher, A.E."'

1. Association of diabetes with age-related macular degeneration in the EUREYE study

Author

Topouzis, F., Anastasopoulos, E., Augood, C., Bentham, G.C., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Vingerling, J.R., Vioque, J., Young, I.S., and Fletcher, A.E.

Subjects
Macular degeneration -- Development and progression, Macular degeneration -- Risk factors, Macular degeneration -- Research, Diabetes -- Complications and side effects, Diabetes -- Research, Health
Published
2009

7. How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? (Clinical Science)

Author

Owen, C.G., Fletcher, A.E., Donoghue, M., and Rudnicka, A.R.

Subjects
Aged -- Physiological aspects -- Research, Macular degeneration -- Research, Ophthalmology -- Research -- Physiological aspects, Health
Abstract

Aims: To predict the burden of blindness, partial sight, and visual impairment (binocular visual acuity 6/18 or less] due to late stage age related macular degeneration (AMD) in the ageing [...]

Published
2003

8. Prevalence of visual impairment in people aged 75 years and older in Britain: results from the MRC trial of assessment and management of older people in the community. (Clinical Science)

Author

Evans, J.R, Fletcher, A.E., Wormald, R.P.L., Ng, E. Siu-Woon, Stirling, S., Smeeth, L., Breeze, E., Bulpitt, C.J., Nunes, M., Jones, D., and Tulloch, A.

Subjects
Aged -- Health aspects -- Case studies, Vision disorders -- Case studies -- Health aspects, Public health -- Case studies -- Health aspects, Health, Case studies, Health aspects
Abstract

Aims: To measure the prevalence of visual impairment in a large representative sample of people aged 75 years and over participating in the MRC trial of assessment and management of [...]

Published
2002

9. Nutritional supplementation in elderly medical in-patients: a double-blind placebo-controlled trial

Author

Hogarth, M.B., Marshall, P., Lovat, L.B., Palmer, A.J., Frost, C.G., Fletcher, A.E., Nicholl, C.G., and Bulpitt, C.J.

Subjects
Aged patients -- Food and nutrition, Dextrose -- Health aspects, Dietary supplements -- Health aspects, Glucose -- Health aspects, Health, Psychology and mental health, Seniors, Social sciences, Food and nutrition, Health aspects
Abstract

Keywords: Elderly patients, Nutritional supplementation, Vitamins, Glucose. Introduction Many elderly people admitted to hospital are undernourished [1, 2] and this adversely affects their prognosis, in terms of mortality, morbidity and [...]

Published
1996

12. A population based case-control study of cataract and inhaled corticosteroids

Author

Smeeth, L., Boulis, M., Hubbard, R., and Fletcher, A.E.

Subjects
Blindness -- Health aspects -- Prevention -- Complications and side effects -- Case studies -- Care and treatment -- Analysis -- Methods, Corticosteroids -- Health aspects -- Case studies -- Complications and side effects -- Methods -- Analysis, Risk factors (Health) -- Analysis -- Case studies -- Health aspects -- Methods, Adrenocortical hormones -- Health aspects -- Case studies -- Analysis -- Methods, Cataract -- Care and treatment -- Health aspects -- Prevention -- Case studies -- Complications and side effects -- Methods -- Analysis, Methodology -- Analysis -- Case studies -- Methods -- Health aspects, Visually disabled persons -- Health aspects -- Care and treatment -- Case studies -- Methods -- Analysis, Health
Abstract

Br J Ophthalmol 2003;87:1247-1251 Background/aims: Exposure to systemic corticosteroid use is known to be associated with a risk of cataract. Whether law doses of inhaled corticosteroids are associated with an [...]

Published
2003

13. Resource allocation

Author

Spiegelhalter, D.J., Gore, S.M., Fitzpatrick, R., Fletcher, A.E., Jones, D.R., and Cox, D.R.

Subjects
Medical care -- Evaluation -- Measurement, Quality of life -- Measurement, Health, Evaluation, Measurement
Abstract

In our two previous papers we discussed the use of measures of health related quality of life in clinical trials and in describing the health of populations.[1 2] We now [...]

Published
1992

14. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Author

Colijn, J.M. (Johanna), Buitendijk, G.H.S. (Gabrielle), Prokofyeva, E. (Elena), Alves, D. (Dalila), Cachulo, M.L. (Maria L.), Khawaja, A.P. (Anthony), Cougnard-Grégoire, A. (Audrey), Merle, B.M.J. (Bénédicte M.J.), Korb, C. (Christina), Erke, M.G. (Maja Gran), Bron, A. (Alain), Anastasopoulos, E. (Eleftherios), Meester-Smoor, M.A. (Magda), Segato, T. (Tatiana), Piermarocchi, S. (Stefano), Jong, P.T.V.M. (Paulus) de, Vingerling, J.R. (Hans), Topouzis, F. (Fotis), Creuzot-Garcher, C. (Catherine), Bertelsen, G. (Geir), Pfeiffer, A.F.H. (Andreas), Fletcher, A.E. (Astrid E.), Foster, P.J. (Paul), Silva, R. (Rufino), Korobelnik, J.-F. (Jean-François), Delcourt, C. (Cécile), Klaver, C.C.W. (Caroline), Ajana, S. (Soufiane), Arango-Gonzalez, B. (Blanca), Arndt, V. (Verena), Bhatia, V. (Vaibhav), Bhattacharya, S.S. (Shomi S.), Biarnés, M. (Marc), Borrell, A. (Anna), Bühren, S. (Sebastian), Calado, S.M. (Sofia M.), Colijn, J.M. (Johanna M.), Dammeier, S. (Sascha), Jong, E.K. (Eiko) de, De la Cerda, B. (Berta), den Hollander, A.I. (Anneke I.), Diaz-Corrales, F.J. (Francisco J.), Diether, S. (Sigrid), Emri, E. (Eszter), Endermann, T. (Tanja), Ferraro, L.L. (Lucia L.), Garcia, M. (Míriam), Heesterbeek, T.J. (Thomas J.), Honisch, S. (Sabina), Hoyng, C.B. (Carel B.), Kersten, E. (Eveline), Kilger, E. (Ellen), Klaver, C.C.W. (Caroline C.W.), Langen, H. (Hanno), Lengyel, I. (Imre), Luthert, P. (Phil), Maugeais, C. (Cyrille), Meester-Smoor, M. (Magda), Monés, J. (Jordi), Nogoceke, E. (Everson), Peto, T. (Tunde), Pool, F.M. (Frances M.), Rodríguez, E. (Eduardo), Ueffing, M. (Marius), Ulrich Bartz-Schmidt, K.U. (Karl U.), van Leeuwen, E.M. (Elisabeth M.), Verzijden, T. (Timo), Zumbansen, M. (Markus), Acar, N. (Niyazi), Anastosopoulos, E. (Eleftherios), Azuara-Blanco, A. (Augusto), Bergen, A.A.B. (Arthur), Binquet, C. (Christine), Bird, A.C. (Alan), Bretillon, L. (Lionel), Buitendijk, G. (Gabrielle), Cachulo, M.L. (Maria Luz), Chakravarthy, U. (Usha), Chan, M. (Michelle), Chang, P. (Petrus), Colijn, J. (Johanna), Cumberland, P. (Phillippa), Cunha-Vaz, J. (José), Daien, V. (Vincent), Deak, G. (Gabor), Delyfer, M.-N. (Marie-Noëlle), Hollander, A.I. (Anneke), Dietzel, M. (Martha), Fauser, S. (Sascha), Finger, R. (Robert), Fletcher, A. (Astrid), Foster, P.J. (Paul J.), Founti, P. (Panayiota), Göbel, A. (Arno), Gorgels, T.G.M.F. (Theo), Grauslund, J. (Jakob), Grus, F. (Franz), Hammond, C.J. (Christopher), Helmer, C. (Catherine), Hense, H.-W. (Hans-Werner), Hermann, M. (Manuel), Hoehn, R. (René), Hogg, R. (Ruth), Holz, F.G. (Frank), Hoyng, C.B. (Carel), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Khawaja, A. (Anthony), Lamparter, J. (Julia), Le Goff, M. (Mélanie), Leal, S. (Sergio), Lechanteur, Y.T.E. (Yara T. E.), Lehtimäki, T. (Terho), Lotery, A.J. (Andrew), Leung, I. (Irene), Mauschitz, M. (Matthias), Merle, B. (Bénédicte), Meyer zu Westrup, V. (Verena), Midena, E. (Edoardo), Miotto, S. (Stefania), Mirshahi, A. (Alireza), Mohan-Saïd, S. (Sadek), Mueller, M. (Michael), Muldrew, A. (Alyson), Nunes, S. (Sandrina), Oexle, K. (Konrad), Peto, T. (Tünde), Rahi, J. (Jugnoo), Raitakari, O. (Olli), Ribeiro, L. (Luisa), Rougier, M.-B. (Marie-Bénédicte), Sahel, J.-A. (José-Alain), Salonikiou, A. (Aggeliki), Sanchez, C. (Clarisa), Schmitz-Valckenberg, S. (Steffen), Schweitzer, C.M.C. (C. M C), Shehata, J. (Jasmin), Silvestri, G. (Giuliana), Simader, C. (Christian), Souied, E.H. (Eric), Springelkamp, H. (Henriët), Tapp, R. (Robyn), Verhoeven, V. (Virginie), Von Hanno, T. (Therese), Vujosevic, S. (Stela), Williams, K. (Katie), Wolfram, C. (Christian), Yip, J. (Jennifer), Zerbib, J. (Jennyfer), Zwiener, I. (Isabella), Colijn, J.M. (Johanna), Buitendijk, G.H.S. (Gabrielle), Prokofyeva, E. (Elena), Alves, D. (Dalila), Cachulo, M.L. (Maria L.), Khawaja, A.P. (Anthony), Cougnard-Grégoire, A. (Audrey), Merle, B.M.J. (Bénédicte M.J.), Korb, C. (Christina), Erke, M.G. (Maja Gran), Bron, A. (Alain), Anastasopoulos, E. (Eleftherios), Meester-Smoor, M.A. (Magda), Segato, T. (Tatiana), Piermarocchi, S. (Stefano), Jong, P.T.V.M. (Paulus) de, Vingerling, J.R. (Hans), Topouzis, F. (Fotis), Creuzot-Garcher, C. (Catherine), Bertelsen, G. (Geir), Pfeiffer, A.F.H. (Andreas), Fletcher, A.E. (Astrid E.), Foster, P.J. (Paul), Silva, R. (Rufino), Korobelnik, J.-F. (Jean-François), Delcourt, C. (Cécile), Klaver, C.C.W. (Caroline), Ajana, S. (Soufiane), Arango-Gonzalez, B. (Blanca), Arndt, V. (Verena), Bhatia, V. (Vaibhav), Bhattacharya, S.S. (Shomi S.), Biarnés, M. (Marc), Borrell, A. (Anna), Bühren, S. (Sebastian), Calado, S.M. (Sofia M.), Colijn, J.M. (Johanna M.), Dammeier, S. (Sascha), Jong, E.K. (Eiko) de, De la Cerda, B. (Berta), den Hollander, A.I. (Anneke I.), Diaz-Corrales, F.J. (Francisco J.), Diether, S. (Sigrid), Emri, E. (Eszter), Endermann, T. (Tanja), Ferraro, L.L. (Lucia L.), Garcia, M. (Míriam), Heesterbeek, T.J. (Thomas J.), Honisch, S. (Sabina), Hoyng, C.B. (Carel B.), Kersten, E. (Eveline), Kilger, E. (Ellen), Klaver, C.C.W. (Caroline C.W.), Langen, H. (Hanno), Lengyel, I. (Imre), Luthert, P. (Phil), Maugeais, C. (Cyrille), Meester-Smoor, M. (Magda), Monés, J. (Jordi), Nogoceke, E. (Everson), Peto, T. (Tunde), Pool, F.M. (Frances M.), Rodríguez, E. (Eduardo), Ueffing, M. (Marius), Ulrich Bartz-Schmidt, K.U. (Karl U.), van Leeuwen, E.M. (Elisabeth M.), Verzijden, T. (Timo), Zumbansen, M. (Markus), Acar, N. (Niyazi), Anastosopoulos, E. (Eleftherios), Azuara-Blanco, A. (Augusto), Bergen, A.A.B. (Arthur), Binquet, C. (Christine), Bird, A.C. (Alan), Bretillon, L. (Lionel), Buitendijk, G. (Gabrielle), Cachulo, M.L. (Maria Luz), Chakravarthy, U. (Usha), Chan, M. (Michelle), Chang, P. (Petrus), Colijn, J. (Johanna), Cumberland, P. (Phillippa), Cunha-Vaz, J. (José), Daien, V. (Vincent), Deak, G. (Gabor), Delyfer, M.-N. (Marie-Noëlle), Hollander, A.I. (Anneke), Dietzel, M. (Martha), Fauser, S. (Sascha), Finger, R. (Robert), Fletcher, A. (Astrid), Foster, P.J. (Paul J.), Founti, P. (Panayiota), Göbel, A. (Arno), Gorgels, T.G.M.F. (Theo), Grauslund, J. (Jakob), Grus, F. (Franz), Hammond, C.J. (Christopher), Helmer, C. (Catherine), Hense, H.-W. (Hans-Werner), Hermann, M. (Manuel), Hoehn, R. (René), Hogg, R. (Ruth), Holz, F.G. (Frank), Hoyng, C.B. (Carel), Jansonius, N.M. (Nomdo), Janssen, S.F. (Sarah), Khawaja, A. (Anthony), Lamparter, J. (Julia), Le Goff, M. (Mélanie), Leal, S. (Sergio), Lechanteur, Y.T.E. (Yara T. E.), Lehtimäki, T. (Terho), Lotery, A.J. (Andrew), Leung, I. (Irene), Mauschitz, M. (Matthias), Merle, B. (Bénédicte), Meyer zu Westrup, V. (Verena), Midena, E. (Edoardo), Miotto, S. (Stefania), Mirshahi, A. (Alireza), Mohan-Saïd, S. (Sadek), Mueller, M. (Michael), Muldrew, A. (Alyson), Nunes, S. (Sandrina), Oexle, K. (Konrad), Peto, T. (Tünde), Rahi, J. (Jugnoo), Raitakari, O. (Olli), Ribeiro, L. (Luisa), Rougier, M.-B. (Marie-Bénédicte), Sahel, J.-A. (José-Alain), Salonikiou, A. (Aggeliki), Sanchez, C. (Clarisa), Schmitz-Valckenberg, S. (Steffen), Schweitzer, C.M.C. (C. M C), Shehata, J. (Jasmin), Silvestri, G. (Giuliana), Simader, C. (Christian), Souied, E.H. (Eric), Springelkamp, H. (Henriët), Tapp, R. (Robyn), Verhoeven, V. (Virginie), Von Hanno, T. (Therese), Vujosevic, S. (Stela), Williams, K. (Katie), Wolfram, C. (Christian), Yip, J. (Jennifer), Zerbib, J. (Jennyfer), and Zwiener, I. (Isabella)

Abstract

Purpose Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. Design Meta-analysis of prevalence data. Participants A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. Methods AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). Main Outcome Measures Prevalence of early and late AMD, BCVA, and number of AMD cases. Results Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%–5.0%) in those aged 55–59 years to 17.6% (95% C

Published
2017
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15. Novel quantitative pigmentation phenotyping enhances genetic association, epistasis, and prediction of human eye colour

Author

Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), Kayser, M.H. (Manfred), Wollstein, A. (Andreas), Walsh, S. (Susan), Liu, F. (Fan), Chakravarthy, U. (Usha), Rahu, M., Seland, J.H. (Johan ), Soubrane, G., Tomazzoli, L. (Laura), Topouzis, F. (Fotis), Vingerling, J.R. (Hans), Vioque, J. (Jesus), Böhringer, S. (Stefan), Fletcher, A.E. (Astrid E.), and Kayser, M.H. (Manfred)

Abstract

Success of genetic association and the prediction of phenotypic traits from DNA are known to depend on the accuracy of phenotype characterization, amongst other parameters. To overcome limitations in the characterization of human iris pigmentation, we introduce a fully automated approach that specifies the areal proportions proposed to represent differing pigmentation types, such as pheomelanin, eumelanin, and non-pigmented areas within the iris. We demonstrate the utility of this approach using high-resolution digital eye imagery and genotype data from 12 selected SNPs from over 3000 European samples of seven populations that are part of the EUREYE study. In comparison to previous quantification approaches, (1) we achieved an overall improvement in eye colour phenotyping, which provides a better separation of manually defined eye colour categories. (2) Single nucleotide polymorphisms (SNPs) known to be involved in human eye colour variation showed stronger associations with our approach. (3) We found new and confirmed previously noted SNP-SNP interactions. (4) We increased SNP-based prediction accuracy of quantitative eye colour. Our findings exemplify that precise quantification using the perceived biological basis of pigmentation leads to enhanced genetic association and prediction of eye colour. We expect our approach to deliver new pigmentation genes when applied to genome-wide association testing.

Published
2017
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16. [Accepted Manuscript] Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study

Author

McKay, G.J., Young, I.S., McGinty, A., Bentham, G.C.G., Chakravarthy, U., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., de Jong, P.T.V.M., and Fletcher, A.E.

Subjects
genetic structures, sense organs, eye diseases
Abstract

Purpose: To study associations between early and late age-related macular degeneration (AMD) and neovascular AMD (nvAMD) with serum 25-hydroxy vitamin D (25(OH)D) and genetic variants in vitamin D pathway genes.

Published
2016

18. Factors associated with serum/plasma concentrations of vitamins A, C, E and cartenoids in older people throughout Europe: the EUREYE study.

Author

Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Woodside, J.V., Young, I.S., Gilchrist, S.E.C.M., Vioque, J., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2013

19. ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study.

Author

Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., Fletcher, A.E., Chakravarthy, U., McKay, G.J., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Toppouzis, F., Vingerling, J.R., Vioque, J., Young, I.S., Sofat, R., Hingorani, A.D., and Fletcher, A.E.

Published
2013

20. Global prevalence and major risk factors of diabetic retinopathy

Author

Yau, J.W.Y. (Joanne W.), Rogers, S.L. (Sophie), Kawasaki, Y., Lamoureux, E.L. (Ecosse), Kowalski, J.W. (Jonathan), Bek, T. (Toke), Chen, S.-J. (Shih-Jen), Dekker, J.M. (Jacqueline), Fletcher, A.E. (Astrid E.), Grauslund, J. (Jakob), Haffner, R.C.G., Hamman, U. (Ute), Ikram, M.K. (Kamran), Kayama, T. (Takamasa), Klein, B.E.K. (Barbara), Krishnaiah, S. (Sannapaneni), Mayurasakorn, K. (Korapat), O'Hare, J.P. (Joseph), Orchard, T., Porta, M., Rema, M. (Mohan), Roy, M.S. (Monique), Sharma, T. (Tarun), Saw, S-M. (Seang-Mei), Taylor, H. (Hugh), Tielsch, J.M. (James), Varma, D. (Dhiraj), Wang, J.J. (Jie Jin), Wang, N. (Ningli), West, S. (Sheila), Zu, L. (Liang), Yasuda, M. (Maya), Zhang, X. (Xinzhi), Mitchell, P. (Paul), Wong, T.Y. (Tien Yin), Yau, J.W.Y. (Joanne W.), Rogers, S.L. (Sophie), Kawasaki, Y., Lamoureux, E.L. (Ecosse), Kowalski, J.W. (Jonathan), Bek, T. (Toke), Chen, S.-J. (Shih-Jen), Dekker, J.M. (Jacqueline), Fletcher, A.E. (Astrid E.), Grauslund, J. (Jakob), Haffner, R.C.G., Hamman, U. (Ute), Ikram, M.K. (Kamran), Kayama, T. (Takamasa), Klein, B.E.K. (Barbara), Krishnaiah, S. (Sannapaneni), Mayurasakorn, K. (Korapat), O'Hare, J.P. (Joseph), Orchard, T., Porta, M., Rema, M. (Mohan), Roy, M.S. (Monique), Sharma, T. (Tarun), Saw, S-M. (Seang-Mei), Taylor, H. (Hugh), Tielsch, J.M. (James), Varma, D. (Dhiraj), Wang, J.J. (Jie Jin), Wang, N. (Ningli), West, S. (Sheila), Zu, L. (Liang), Yasuda, M. (Maya), Zhang, X. (Xinzhi), Mitchell, P. (Paul), and Wong, T.Y. (Tien Yin)

Abstract

OBJECTIVE - To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS - A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence estimates were directly age-standardized to the 2010 World Diabetes Population aged 20-79 years. RESULTS - A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin A1c, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS - There are approximately 93 million people with DR, 17 million with proliferative DR, 21million with diabeticmacular edema, and 28million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with different methodologies and population characteristics.

Published
2012
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21. Associations between aspirin use and aging macula disorder.

Author

de Jong, P.T.V.M., Chakravarthy, U., Rahu, M., Seland, J., Soubrane, G., Topouzis, F., Vingerling, J.R., Vioque, J., Young, I., Fletcher, A.E., de Jong, P.T.V.M., Chakravarthy, U., Rahu, M., Seland, J., Soubrane, G., Topouzis, F., Vingerling, J.R., Vioque, J., Young, I., and Fletcher, A.E.

Published
2012

22. Visual impairment and quality of life in the older European population, the EUREYE study.

Author

Seland, J.H., Vingerling, J.R., Augood, C.A., Bentham, G., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Soubrane, G., Tomazolli, L., Topouzis, F., Fletcher, A.E., Seland, J.H., Vingerling, J.R., Augood, C.A., Bentham, G., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Soubrane, G., Tomazolli, L., Topouzis, F., and Fletcher, A.E.

Published
2011

23. Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies.

Author

McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., Silvestri, G., McKay, G.J., Patterson, C.C., Chakravarthy, U., Dasari, S., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Fletcher, A.E., Young, I.S., Seland, J.H., Rahhu, M., Soubrane, G., Tomazzoli, L., Topouzis, F., Vioque, J., Hingorani, A.D., Sofat, R., Dean, M., Sawitzke, J., Seddon, J.M., Peter, I., Webster, A.R., Moore, A.T., Yates, J.R., Cipriani, V., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Lotery, A.J., Ennis, S., Klein, M.L., Francis, P.J., Stambolian, D., Orlin, A., Gorin, M.B., Weeks, D.E., Kuo, C.L., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Wright, A.F., Hayward, C., Baird, P.N., Guymer, R.H., Attia, J., Thakkinstian, A., and Silvestri, G.

Published
2011

24. Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.

Author

McKay, G.J., Silvestri, G., Chakravarthy, U., Dasari, S., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Klein, M.L., Francis, P.J., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Dean, M., Sawitzke, J., Baird, P.N., Guymer, R.H., Stambolian, D., Orlin, A., Seddon, J.M., Peter, I., Wright, A.F., Hayward, C., Lotery, A.J., Ennis, S., Gorin, M.B., Weeks, D.E., Kuo, C.L., Hingorani, A.D., Sofat, R., Cipriani, V., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Yates, J.R., Webster, A.R., Moore, A.T., Seland, J.H., Rahu, M., Soubrane, G., Tomazolli, L., Topouzis, F., Vioque, J., Young, I.S., Fletcher, A.E., Patterson, C.C., McKay, G.J., Silvestri, G., Chakravarthy, U., Dasari, S., Fritsche, L.G., Weber, B.H., Keilhauer, C.N., Klein, M.L., Francis, P.J., Klaver, C.C., Vingerling, J.R., Ho, L., de Jong, P.T.V.M., Dean, M., Sawitzke, J., Baird, P.N., Guymer, R.H., Stambolian, D., Orlin, A., Seddon, J.M., Peter, I., Wright, A.F., Hayward, C., Lotery, A.J., Ennis, S., Gorin, M.B., Weeks, D.E., Kuo, C.L., Hingorani, A.D., Sofat, R., Cipriani, V., Swaroop, A., Othman, M., Kanda, A., Chen, W., Abecasis, G.R., Yates, J.R., Webster, A.R., Moore, A.T., Seland, J.H., Rahu, M., Soubrane, G., Tomazolli, L., Topouzis, F., Vioque, J., Young, I.S., Fletcher, A.E., and Patterson, C.C.

Published
2011

25. Sunlight exposure, antioxidants, and age-related macular degeneration.

Author

Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Vioque, J., Fletcher, A.E., Bentham, G.C., Agnew, M., Young, I.S., Augood, C.A., Chakravarthy, U., de Jong, P.T.V.M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Vioque, J.

Published
2008

26. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.

Author

Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Fletcher, A.E., Augood, S., Chakravarthy, U., Young, I., Vioque, J., de Jong, P.T.V.M., Bentham, G.C., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., and Fletcher, A.E.

Published
2008

28. Cigarette Smoking and Age-Related Macular Degeneration in the EUREYE Study

Author

Chakravarthy, U., primary, Augood, C., additional, Bentham, G.C., additional, de Jong, P.T.V.M., additional, Rahu, M., additional, Seland, J., additional, Soubrane, G., additional, Tomazzoli, L., additional, Topouzis, F., additional, Vingerling, J.R., additional, Vioque, J., additional, Young, I.S., additional, and Fletcher, A.E., additional

Published
2007
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31. Cancer mortality and atenolol treatment

Author

Fletcher, A.E., Beevers, D.G., Bulpitt, C.J., Coles, E.C., Dollery, C.T., Ledingham, J.G., Palmer, A.J., Petrie, J.C., and Webster, J.

Subjects
Cancer -- Risk factors, Atenolol -- Health aspects, Health, Risk factors, Health aspects
Abstract

In the Medical Research Council's randomised trial of elderly hypertensive patients, men receiving atenolol had a higher death rate from cancer than those receiving diuretic or placebo.[1] This was not [...]

Published
1993

35. Review: Audit measures: Quality of life instruments for everyday use with elderly patients.

Author

Fletcher, A.E. and Dickinson, E.J.

Subjects
*HEALTH of older people
Abstract

Considers the importance of the use of scales in setting goals for the health care of elderly people. Conceptualization of quality of life for elderly people; Selection of instruments; Why quality of care should be measured; Role of multidimensional assessments; Nottingham Health Profile (NHP); The Sickness Impact Profile (SIP); Life Satisfaction Index (LSIA); More.

Published
1992
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36. How far should blood pressure be lowered?

Author

Fletcher, A.E. and Bulpitt, C.J.

Subjects
*BLOOD pressure
Abstract

Discusses the benefits and risks of lowering blood pressure in patients with hypertension and argues that the putative cause-and-effect relation between the reduction in blood pressure and and upward slope of mortality is spurious. Summary of thestudies relating the level of blood pressure during treatment for hypertension to the risk of stroke and coronary heart disease; The Medical Research Council (MRC) Trial; More.

Published
1992

39. Quality of life measures in health care. III: resources allocation.

Author

Spiegelhalter, D.J., Gore, S.M., Fitzpatrick, R., Fletcher, A.E., Jones, D.R., and Cox, D.R.

Subjects
QUALITY of life, MEDICAL care, HEALTH care rationing
Abstract

Focuses on the quality of life in health care in Great Britain. Significance of using the quality adjusted life year (QALY) in patients; Issues on health care rationing; Enumeration of QALY analysis stages.

Published
1992
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40. Atrial natriuretic factor receptors and stimulation of cyclic GMP formation in normal and malignant osteoblasts

Author

Fletcher, A.E., Allan, E.H., Casley, D.J., and Martin, T.J.

Abstract

Synthetic rat atrial natriuretic factor (Ile-ANF-26) stimulated cyclic GMP formation by up to several hundred-fold in osteoblast-rich cultures from newborn rat calvaria and in clonal osteogenic sarcoma cells (UMR 106-01) which are phenotypically osteoblast. ANF had no effect on the cyclic AMP response to parathyroid hormone in the same cells. Specific, high-affinity binding sites for ANF were identified in both cell types, with K dand receptor numbers in normal osteoblasts of 1.2 ± 0.1 × 10 −10M and 42 ± 4 × 10 3per cell, and in UMR 106-01 cells of 1.4 ± 0.1 × 10 −10M and 22 ± 4 × 10 3per cell.

Published
1986
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41. Quality of life in chronic heart failure: cilazapril and captopril versus placebo

Author

Bulpitt, C.J., Fletcher, A.E., Dössegger, L., Nielsen, T., Neiss, A., and Viergutz, S.

Abstract

Objective To measure quality of life (QOL) in patients with mild to moderate heart failure treated with angiotensin converting enzyme (ACE) inhibitors cilazapril or captopril. Design Randomised, double blind, placebo controlled, parallel groups trial. Subjects 367 patients with New York Heart Association (NYHA) heart failure class II (62%), III (36%) or IV (1%). Methods Patients were randomised to receive cilazapril 1 mg daily (n = 191) or captopril 25 mg three times daily (n = 90) for 24 weeks, or placebo for 12 weeks followed by cilazapril 1 mg daily for a further 12 weeks (n = 86). If patients had not responded after four weeks cilazapril was increased to 2.5 mg daily and captopril to 50 mg three times daily. QOL was assessed at baseline, 12, and 24 weeks using the sickness impact profile (SIP), the profile of mood states (POMS), the Mahler index of dyspnoea-fatigue, and a health status index (HSI). Results The physical dimension of the SIP averaged 7 units at baseline and improved after 12 weeks by 2.24 units in the cilazapril group, 2.38 units in the captopril group, and 1.51 units in the placebo group. The difference between drug and placebo was therefore 0.73 units (95% CI -0.86 to 2.32) for cilazapril, and 0.87 units (95% CI -0.96 to 2.70) for captopril, with small non-significant effect sizes (a statistical method for estimating the importance of a treatment related change) of 0.12 and 0.14. Similar results were observed for the total POMS and HSI scores. Although QOL improved more on the ACE inhibitors than on placebo, the effect sizes were not significant (≤ 0.26). Conclusions Improvements in QOL in mild to moderate heart failure were small when treated with cilazapril or captopril compared with placebo.

Published
1998

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