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Your search keyword '"Fleischmann, Christina"' showing total 26 results
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26 results on '"Fleischmann, Christina"'

6. Mutations in PTF1A cause pancreatic and cerebellar agenesis

Author

Sellick, Gabrielle S, primary, Barker, Karen T, additional, Stolte-Dijkstra, Irene, additional, Fleischmann, Christina, additional, J Coleman, Richard, additional, Garrett, Christine, additional, Gloyn, Anna L, additional, Edghill, Emma L, additional, Hattersley, Andrew T, additional, Wellauer, Peter K, additional, Goodwin, Graham, additional, and Houlston, Richard S, additional

Published
2004
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16. Evaluation of xeroderma pigmentosum XPA, XPC, XPD, XPF, XPB, XPG and DDB2 genes in familial early-onset lung cancer predisposition.

Author

Matakidou, Athena, Eisen, Tim, Fleischmann, Christina, Bridle, Helen, and Houlston, Richard S.

Abstract

Epidemiological data has implicated heterozygosity for xeroderma pigmentosum (XP) as a risk factor for lung cancer. XP has 8 known complementation groups, 7 of which are caused by mutations in genes encoding components of the nucleotide excision repair (NER) pathway. To formally investigate the role of XP-related NER genes in lung cancer susceptibility, we screened germline DNA from 92 familial early-onset lung cancer patients for mutations in all coding regions and intron-exon boundaries of XPA, XPC, XPD, XPF, XPB, XPG and DDB2. Forty-one exonic variants were identified. Twenty-four were nonsynonymous, of which 14 were previously documented polymorphisms. Ten missense variants had not been previously described; none of which were detected in germline DNA from 278 cancer-free controls. Two of the novel missense changes are predicted to be functionally deleterious. Our findings are compatible with XP heterozygosity being a risk factor for lung cancer susceptibility. © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2006
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20. Interaction of Mycoplasma with Viruses I. Primary Adsorption of Virus Is Ionic in Mechanism

Author

Fraser, Dean and Fleischmann, Christina

Abstract

We have studied the adsorption of the Gourlay Acholeplasmavirus MVL-1 to the host cell Acholeplasma laidlawiiJA-1. Successful adsorption depends primarily on some unknown action of the serum factor in the medium, but evaluation of various physical parameters indicates clearly that given this factor the kinetics is pseudo first order (K = 3 × 10-9cm3/min) and the mechanism ionic. Chiefly important are the ionic strength of the cation and pH (optimal Na+= 0.08 M, pH = 6). The system seems indifferent to whether the cation is Na, K, NH4, Ca, or Mg. There is little effect of temperature over the range 0 to 42 C. The diffusion constant of the virus, calculated from its geometry or its maximum adsorption rate, is consistent with its reported size and shape.

Published
1974
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25. Mit sechs Monaten schon Straßenmusiker.

Author

Fleischmann, Christina

Subjects
PUBLISHED reprints, BAYREUTHER Festspiele, STREET musicians
Abstract

The article presents a reprint of the article "Mit sechs Monaten schon Straßenmusiker," by Christina Fleischmann, which was published in the August 11, 2009 issue of the journal "Nordbayerischer Kurier." The article focuses on street musicians Adrian Brown and his wife Susanna Borsch who have come to see the Bayreuth Festival held in Bayreuth, Germany. The family has come from Amsterdam, the Netherlands, and their repertoire has mainly popular songs by British artists.

Published
2010

26. Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer.

Author

Fleischmann C, Peto J, Cheadle J, Shah B, Sampson J, and Houlston RS

Subjects
Adenocarcinoma enzymology, Adenocarcinoma genetics, Adenocarcinoma pathology, Adult, Age of Onset, Allelic Imbalance, Case-Control Studies, Colon metabolism, Colorectal Neoplasms enzymology, Colorectal Neoplasms pathology, Female, Humans, Male, Middle Aged, Rectum metabolism, United Kingdom, Colorectal Neoplasms genetics, DNA Glycosylases genetics, Genetic Variation, Germ-Line Mutation
Abstract

Mutations in the base excision repair gene MYH have recently been shown to confer recessive susceptibility to colorectal adenomas and carcinomas. To evaluate the contribution of germline MYH mutations to early-onset colorectal cancer, we screened a series of 358 unselected early-onset cases for germline changes in the coding sequence of the gene. Two cases harbored biallelic germline mutations (0.6%; 95% CI = 0.06-2.0) and 8 single MYH mutations (2.2%; 95% CI = 0.9-4.4). Both cases harboring biallelic MYH mutations had multiple polyps but not profuse polyposis. All cases had distally sited tumors. No biallelic mutations were detected among 354 controls. These results confirm that biallelic MYH mutations confer susceptibility to colorectal cancer but are unlikely to account for more than 3% of early-onset colorectal cancer., (Copyright 2004 Wiley-Liss, Inc.)

Published
2004
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