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109 results on '"Fleischmann, B. K."'

5. Moloney Murine Leukemia Virus: A Powerful Tool to Genetically Manipulate Cardiac and Noncardiac Fibroblasts

Author

Mohr, T., additional, Schiffer, M., additional, Niemann, P., additional, Geisen, C., additional, Carls, E., additional, Mykhaylyk, O., additional, Hildebrand, S., additional, Pfeifer, A., additional, Ramanujam, D., additional, Engelhardt, S., additional, Funken, M., additional, Bakhtiary, F., additional, Fleischmann, B. K., additional, and Roell, W., additional

Published
2022
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11. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity

Author

Gnad, T., Navarro, G., Lahesmaa, M., Reverte-Salisa, L., Copperi, F., Cordomi, A., Naumann, J., Hochh€Auser, A., Haufs-Brusberg, S., Wenzel, D., Suhr, F., Zenius Jespersen, N., Scheele, C., Tsvilovskyy, V., Brinkmann, C., Rittweger, J., Dani, C., Kranz, M., (0000-0003-3168-3062) Deuther-Conrad, W., Eltzschig, H. K., Niemi, T., Taittonen, M., Brust, P., Nuutila, P., Pardo, L., Fleischmann, B. K., Bleuher, M., Franco, R., Bloch, W., Virtanen, K. A., Pfeifer, A., Gnad, T., Navarro, G., Lahesmaa, M., Reverte-Salisa, L., Copperi, F., Cordomi, A., Naumann, J., Hochh€Auser, A., Haufs-Brusberg, S., Wenzel, D., Suhr, F., Zenius Jespersen, N., Scheele, C., Tsvilovskyy, V., Brinkmann, C., Rittweger, J., Dani, C., Kranz, M., (0000-0003-3168-3062) Deuther-Conrad, W., Eltzschig, H. K., Niemi, T., Taittonen, M., Brust, P., Nuutila, P., Pardo, L., Fleischmann, B. K., Bleuher, M., Franco, R., Bloch, W., Virtanen, K. A., and Pfeifer, A.

Abstract

The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown adipose tissue (BAT) and might be targeted to counteract age-related muscle atrophy (sarcopenia) as well as obesity. Mice with SKM-specific deletion of A2B exhibited sarcopenia, diminished muscle strength, and reduced energy expenditure (EE), whereas pharmacological A2B activation counteracted these processes. Adipose tissue-specific ablation of A2B exacerbated age-related processes and reduced BAT EE, whereas A2B stimulation ameliorated obesity. In humans, A2B expression correlated with EE in SKM, BAT activity, and abundance of thermogenic adipocytes in white fat. Moreover, A2B agonist treatment increased EE from human adipocytes, myocytes, and muscle explants. Mechanistically, A2B forms heterodimers required for adenosine signaling. Overall, adenosine/A2B signaling links muscle and BAT and has both anti-aging and anti–obesity potential.

Published
2020

16. Transcription factor: induced pluripotency: KL043

Author

Zaehres, H, Kim, J B, Greber, B, Wu, G, Bravo, Arauzo M, Singhal, N, Cantz, T, Bleidissel, M, Fischedick, G, Zeuschner, D, Sebastiano, V, Gentile, L, Do, J T, Ko, K, Han, D W, Sterneckert, J, Ruau, D, Sasse, P, Meyer, J, Fleischmann, B K, Zenke, M, and Schöler, H R

Published
2009

22. Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016

Author

Olschewski, A., Berghausen, E. M., Eichstaedt, C. A., Fleischmann, B. K., Gruenig, E., Gruenig, G., Hansmann, G., Harbaum, L., Hennigs, J. K., Jonigk, D., Kuebler, W. M., Kwapiszewska, G., Pullamsetti, S. S., Stacher, E., Weissmann, N., Wenzel, D., Schermuly, R. T., Olschewski, A., Berghausen, E. M., Eichstaedt, C. A., Fleischmann, B. K., Gruenig, E., Gruenig, G., Hansmann, G., Harbaum, L., Hennigs, J. K., Jonigk, D., Kuebler, W. M., Kwapiszewska, G., Pullamsetti, S. S., Stacher, E., Weissmann, N., Wenzel, D., and Schermuly, R. T.

Abstract

The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension (PH) are also valid for Germany. While the guidelines contain detailed recommendations regarding clinical aspects of pulmonary arterial hypertension (PAH) and other forms of PH, they contain only a relatively short paragraph on novel findings on the pathobiology, pathology, and genetics. However, these are of great importance for our understanding of this complex disease both from a clinical and scientific point of view, and they are essential for the development of novel treatment strategies. To this end, a number of current data are relevant, prompting a detailed commentary to the guidelines, and the consideration of new scientific data. In June 2016, a Consensus Conference organized by the PH working groups of the German Society of Cardiology (DGK), the German Society of Respiratory Medicine (DGP) and the German Society of Pediatric Cardiology (DGPK) was held in Cologne, Germany. This conference aimed to solve practical and controversial issues surrounding the implementation of the European Guidelines in Germany. To this end, a number of working groups was initiated, one of which was specifically dedicated to the pathobiology, pathology and genetics of PH. This article summarizes the results and recommendations of this working group.

Published
2016

23. 3D microtissue formation of undifferentiated bone marrow mesenchymal stem cells leads to elevated apoptosis

Author

Kelm, J M, Breitbach, M, Fischer, G, Odermatt, B, Agarkova, I, Fleischmann, B K, Hoerstrup, S P, University of Zurich, and Kelm, J M

Subjects
10022 Division of Surgical Research, 1303 Biochemistry, 1502 Bioengineering, 2502 Biomaterials, 570 Life sciences, biology, 2204 Biomedical Engineering, 610 Medicine & health, 10239 Institute of Laboratory Animal Science, 11359 Institute for Regenerative Medicine (IREM), 10020 Clinic for Cardiac Surgery
Published
2012
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25. Implication of therapeutic cloning for organ transplantation

Author

Hescheler, Jürgen, Wartenberg, Maria, Wenzel, D., Roell, B. K., Lu, Z., Xia, Y., Donmez, F., Ling, Frederike C., Acker, Helmut, Kolossov, E., Kazemi, S., Sasse, P., Raible, A., Bohlen, H., and Fleischmann, B. K.

Subjects
Institut für Biochemie und Biologie
Published
2004

28. Oral abstract presentations & Young Investigators Competition

Author

Leone, A., primary, Aquila, I., additional, Vicinanza, C., additional, Iaconetti, C., additional, Bochicchio, A., additional, Ottolenghi, S., additional, Indolfi, C., additional, Nadal-Ginard, B., additional, Ellison, G. M., additional, Torella, D., additional, Mias, C., additional, Genet, G., additional, Guilbeau-Frugier, C., additional, Pathak, A., additional, Senard, J. M., additional, Gales, C., additional, Egorova, A. D., additional, Khedoe, P. S. J., additional, Goumans, M. T. H., additional, Nauli, S. M., additional, Ten Dijke, P., additional, Poelmann, R. E., additional, Hierck, B. P., additional, Miragoli, M., additional, Lab, M. J., additional, Singh, A., additional, Sikkel, M., additional, Lyon, A., additional, Gorelik, J., additional, Cheung, C., additional, Bernardo, A. S., additional, Trotter, M. W., additional, Pedersen, R. A., additional, Sinha, S., additional, Mioulane, M., additional, Foldes, G., additional, Harding, S. E., additional, Reglin, B., additional, Secomb, T. W., additional, Pries, A. R., additional, Buckingham, M., additional, Lescroart, F., additional, Meilhac, S., additional, Le Garrec, J.-F., additional, Rozmaritsa, N., additional, Christ, T., additional, Wettwer, E., additional, Knaut, M., additional, Ravens, U., additional, Tokar, S., additional, Schobesberger, S., additional, Wright, P. T., additional, Lyon, A. R., additional, Van Mil, A., additional, Grundmann, S., additional, Goumans, M.-J., additional, Jaksani, S., additional, Doevendans, P. A., additional, Sluijter, J. P., additional, Tijsen, A. J., additional, Amin, A. S., additional, Giudicessi, J. R., additional, Tanck, M. W., additional, Bezzina, C. R., additional, Creemers, E. E., additional, Wilde, A. M., additional, Ackerman, M. J., additional, Pinto, Y. M., additional, Gedicke-Hornung, C., additional, Behrens-Gawlik, V., additional, Khajetoorians, D., additional, Mearini, G., additional, Reischmann, S., additional, Geertz, B., additional, Voit, T., additional, Dreyfus, P., additional, Eschenhagen, T., additional, Carrier, L., additional, Duerr, G. D., additional, Heinemann, J. C., additional, Wenzel, D., additional, Ghanem, A., additional, Alferink, J. C., additional, Zimmer, A., additional, Lutz, B., additional, Welz, A., additional, Fleischmann, B. K., additional, Dewald, O., additional, Sbroggio', M., additional, Bertero, A., additional, Giuliano, L., additional, Brancaccio, M., additional, Tarone, G., additional, Meiser, M., additional, Kohlhaas, M., additional, Chen, Y., additional, Csordas, G., additional, Dorn, G., additional, Maack, C., additional, Stapel, B., additional, Hoch, M., additional, Haghikia, A., additional, Fischer, P., additional, Hilfiker-Kleiner, D., additional, Schroen, B., additional, Corsten, M., additional, Verhesen, W., additional, De Windt, L., additional, Zacchigna, S., additional, Thum, T., additional, Carmeliet, P., additional, Papageorgiou, A., additional, Heymans, S., additional, Lunde, I. G., additional, Finsen, A. V., additional, Florholmen, G., additional, Skrbic, B., additional, Kvaloy, H., additional, Jarstadmarken, H. O., additional, Sjaastad, I., additional, Tonnessen, T., additional, Carlson, C. R., additional, Christensen, G., additional, Paavola, J., additional, Schliffke, S., additional, Rossetti, S., additional, Kuo, I., additional, Yuan, S., additional, Sun, Z., additional, Harris, P., additional, Torres, V., additional, Ehrlich, B., additional, Robinson, P., additional, Adams, K., additional, Zhang, Y.-H., additional, Casadei, B., additional, Watkins, H., additional, Redwood, C., additional, Seneviratne, A. N., additional, Cole, J. E., additional, Goddard, M. E., additional, Mohri, Z., additional, Cross, A. J., additional, Krams, R., additional, Monaco, C., additional, Everaert, B. R., additional, Van Laere, S. J., additional, Hoymans, V. Y., additional, Timmermans, J. P., additional, and Vrints, C. J., additional

Published
2012
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33. Gewebeersatz — eine Perspektive in der Arrhythmiebehandlung.

Author

Lewalter, Thorsten and Fleischmann, B. K.

Abstract

Copyright of Rationale Arrhythmiebehandlung is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2006
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34. Selection of ventricular‐like cardiomyocytes from ES cellsin vitro

Author

MÜller, M., primary, Fleischmann, B. K., additional, Selbert, S., additional, Ji, G. J., additional, Endl, E., additional, Middeler, G., additional, MÜller, O. J., additional, Schlenke, P., additional, Frese, S., additional, Wobus, A. M., additional, Hescheler, J., additional, Katus, H. A., additional, and Franz, W. M., additional

Published
2000
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46. Establishment of Ionic Channels and Signalling Cascades in the Embryonic Stem Cell-Derived Primitive Endoderm and Cardiovascular System.

Author

Hescheler, J., Fleischmann, B. K., Wartenberg, M., Bloch, W., Kolossov, E., Ji, G., Addicks, K., and Sauer, H.

Subjects
*EMBRYONIC stem cells, *STEM cells, *NEOVASCULARIZATION, *BLOOD-vessel development, *CARDIOVASCULAR system
Abstract

The first organ system to be established in early embryogenesis is the cardiovascular system which develops upon interaction with hypoblastic cells of the primitive endoderm. Here we focus on recent work on embryoid bodies derived from pluripotent embryonic stem (ES) cells. Ca[sup 2+] oscillations and Ca[sup 2+] signalling pathways during the differentiation of primitive endodermal cell layers are reported. Furthermore, the development-dependent expression of ion channels and the buildup of signalling cascades involved in the modulation of voltage-dependent L-type Ca[sup 2+] channels during early cardiomyogenesis and the formation of functional vascular structures in the process of vasculogenesis and angiogenesis are reviewed. We also report on the use of green fluorescent protein reporter gene expression under the control of cardiac-specific promoters, e.g. the human cardiac α-actin promoter, which enables the identification and in vivo characterization of cardiomyocytes at very early stages of cardiomyogenesis.Copyright © 1999 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
1999
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48. Role of ATP-dependent K(+) channels in the electrical excitability of early embryonic stem cell-derived cardiomyocytes.

Author

Gryshchenko, O, Fischer, I R, Dittrich, M, Viatchenko-Karpinski, S, Soest, J, Böhm-Pinger, M M, Igelmund, P, Fleischmann, B K, and Hescheler, J

Abstract

Single, murine embryonic stem cell-derived early stage cardiomyocytes dissociated from embryoid bodies expressed two inward rectifier K(+) channels, I(K1) and the ATP dependent K(+) current. I(K1) exhibited low density in early stage cardiomyocytes, but increased significantly in late stage cells. In contrast, the ATP dependent K(+) current was expressed at similar densities in early and late stage cardiomyocytes. This current was found to be involved in the determination of the membrane potential, since glibenclamide depolarized early cardiomyocytes and exerted a positive chronotropic effect. Some cardiomyocytes displayed a bursting behavior of action potentials, characterized by alternating periods with and without action potentials. During the phases without action potentials, the membrane potential was hyperpolarized, indicating the involvement of K(+) channels in the generation of this bursting behavior. Extracellular recording techniques were applied to spontaneously contracting areas of whole embryoid bodies. In 20% of these bursting behavior similar to that seen in the single cells was observed. In regularly beating embryoid bodies, bursting could be induced by reduction of substrates from the extracellular medium as well as by superfusion with the positive chronotropic agents Bay K 8644 or isoproterenol. Perfusion with substrate-reduced medium induced bursting behavior after a short latency, isoproterenol and Bay K 8644 resulted in a positive chronotropic response followed by bursting behavior with longer latencies. The spontaneous bursting was blocked by glibenclamide. These experimental results suggest that intermittent activation of ATP dependent K(+) channels underlies the bursting behavior observed in single cardiomyocytes and in the whole embryoid body. Conditions of metabolic stress lead to the rhythmic suppression of action potential generation. Our data indicate that ATP dependent K(+) channels play a prominent role in the cellular excitability of early cardiomyocytes.

Published
1999

50. Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes.

Author

Kolossov, E., Lu, Z., Drobinskaya, I., Gassanov, N., Duan, Y., Sauer, H., Hescheler, J., Manzke, O., Bloch, W., Bohlen, H., and Fleischmann, B. K.

Subjects
EMBRYONIC stem cells, GREEN fluorescent protein, HEART cells, STEM cells, CELLS, FLUORESCENT polymers
Abstract

Presents a study on the identification and functional characterization of cardiac subtypes during early stages of development using the embryonic stem (ES) cell in vitro differentiation system. Method used to better understand the enhanced green fluorescent protein (EGFP) labeling of ES cell-derived cardiomyocytes; Experiment performed to identify the cardiac subtype and correlate it with its EGFP fluorescence intensity; Analysis permitted by the in vitro differentiation of ES cell-derived cardiomyocytes.

Published
2005
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