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560 results on '"Fleischhaker, Christian"'

1. Therapeutic drug monitoring in children and adolescents with schizophrenia-spectrum, affective, behavioural, tic and other psychiatric disorders treated with aripiprazole: results of the TDM-VIGIL pharmacovigilance study

Author

Riegger, Jessica, Egberts, Karin Maria, Clement, Hans-Willi, Schneider-Momm, Katja, Taurines, Regina, Fekete, Stefanie, Wewetzer, Christoph, Karwautz, Andreas, Correll, Christoph U., Plener, Paul L., Malzahn, Uwe, Heuschmann, Peter, Unterecker, Stefan, Scherf-Clavel, Maike, Rock, Hans, Antony, Gisela, Briegel, Wolfgang, Banaschewski, Tobias, Hellenschmidt, Tobias, Kaess, Michael, Kölch, Michael, Renner, Tobias, Rexroth, Christian, Schulte-Körne, Gerd, Walitza, Susanne, Gerlach, Manfred, Romanos, Marcel, and Fleischhaker, Christian

Published
2024
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4. Therapeutic drug monitoring of sertraline in children and adolescents: A naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder

Author

Tini, Elvira, Smigielski, Lukasz, Romanos, Marcel, Wewetzer, Christoph, Karwautz, Andreas, Reitzle, Karl, Correll, Christoph U., Plener, Paul L., Malzahn, Uwe, Heuschmann, Peter, Unterecker, Stefan, Scherf-Clavel, Maike, Rock, Hans, Antony, Gisela, Briegel, Wolfgang, Fleischhaker, Christian, Banaschewski, Tobias, Hellenschmidt, Tobias, Imgart, Hartmut, Kaess, Michael, Kölch, Michael, Renner, Tobias, Reuter-Dang, Su-Yin, Rexroth, Christian, Schulte-Körne, Gerd, Theisen, Frank, Fekete, Stefanie, Taurines, Regina, Gerlach, Manfred, Egberts, Karin Maria, and Walitza, Susanne

Published
2022
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6. Therapeutic drug monitoring in adolescents with anorexia nervosa for safe treatment with adjunct olanzapine.

Author

Karwautz, Andreas, Zeiler, Michael, Schwarzenberg, Julia, Mairhofer, Dunja, Mitterer, Michaela, Truttmann, Stefanie, Philipp, Julia, Koubek, Doris, Glüder, Maria, Wagner, Gudrun, Malcher, Anouk, Schöfbeck, Gabriele, Laczkovics, Clarissa, Rock, Hans W., Zanko, Annika, Imgart, Hartmut, Banaschewski, Tobias, Fleischhaker, Christian, Correll, Christoph U., and Wewetzer, Christoph

Subjects
PEARSON correlation (Statistics), PATIENT safety, RESEARCH funding, BODY mass index, OLANZAPINE, TREATMENT effectiveness, DESCRIPTIVE statistics, DRUG monitoring, LONGITUDINAL method, ANOREXIA nervosa, EVALUATION, ADOLESCENCE
Abstract

Objective: Medication is commonly used in anorexia nervosa (AN) despite largely missing high grade evidence. Olanzapine (OLZ) is the best‐evidenced substance used off‐label in this group, with conflicting outcome regarding BMI, clinical and safety parameters. Therefore, it is important to strictly assure quality of treatment with OLZ in AN by using 'Therapeutic Drug Monitoring' according to AGNP‐guidelines, including serum levels and adverse drug reactions (ADRs) to support safety for adolescents with AN and attempt to generate an initial age‐ and disorder‐specific therapeutic reference range. Method: Sixty‐five adolescents with AN (aged 10–18) treated with OLZ (98% female; 97.5% AN‐restricting‐type) were prospectively observed, ADRs reported, and correlations between dosage and serum levels measured at trough level were calculated, a preliminary therapeutic range defined. Results: Mean dosage of OLZ was 8.15 (SD: 2.91) mg and 0.19 (SD: 0.07) mg/kg respectively, average concentration was 26.57 (SD: 13.46) ng/mL. Correlation between daily dosage/dosage per kg and serum level was 0.72 (**p < 0.001)/0.65 (**p < 0.001), respectively. ADRs with impairment were rare (6.3%). 75% improved clinically (CGI). BMI increased significantly by 1.5 kg/m2 (t = 10.6, p < 0.001). A preliminary therapeutic reference range is 11.9 and 39.9 ng/mL. Conclusions: OLZ in the hands of specialists is a well‐tolerated and safe treatment adjunct for adolescents with AN. Highlights: Olanzapine in adolescents with anorexia nervosa is a safe and well‐tolerated adjunct to a multidisciplinary inpatient treatment approach using therapeutic drug monitoring.Correlations of dosage and serum levels are high.A preliminary disorder‐ and age‐specific reference range was successfully defined for the first time. [ABSTRACT FROM AUTHOR]

Published
2024
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8. BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization

Author

Borsdorf, Britta, Dahmen, Brigitte, Buehren, Katharina, Dempfle, Astrid, Egberts, Karin, Ehrlich, Stefan, Fleischhaker, Christian, Konrad, Kerstin, Schwarte, Reinhild, Timmesfeld, Nina, Wewetzer, Christoph, Biemann, Ronald, Scharke, Wolfgang, Herpertz-Dahlmann, Beate, and Seitz, Jochen

Subjects
Child psychopathology -- Development and progression, Anorexia nervosa -- Development and progression -- Demographic aspects, Pediatric research, Brain-derived neurotrophic factor -- Measurement -- Health aspects -- Psychological aspects, Health, Psychology and mental health
Abstract

Background: Brain-derived neurotrophic factor (BDNF) influences brain plasticity and feeding behaviour, and it has been linked to anorexia nervosa in numerous studies. Findings in mostly adult patients point to reduced serum BDNF levels in the acute stage of anorexia nervosa and rising levels with weight recovery. However, it is unclear whether this increase leads to normalization or supranormal levels, a difference that is potentially important for the etiology of anorexia nervosa and relapse. Methods: We measured serum BDNF at admission (n = 149), discharge (n = 130), 1-year follow-up (n = 116) and 2.5-year follow-up (n = 76) in adolescent female patients with anorexia nervosa hospitalized for the first time, and in healthy controls (n = 79). We analyzed associations with body mass index, eating disorder psychopathology and comorbidities. Results: Serum BDNF was only nominally lower at admission in patients with anorexia nervosa compared to healthy controls, but it increased continuously and reached supranormal levels at 2.5-year follow-up. BDNF was inversely associated with eating disorder psychopathology at discharge and positively associated with previous weight gain at 1-year follow-up. Limitations: We compensated for attrition and batch effects using statistical measures. Conclusion: In this largest I ongitudinal study to date, we found only nonsignificant reductions in BDNF in the acute stage of anorexia nervosa, possibly because of a shorter illness duration in adolescent patients. Supranormal levels of BDNF at 2.5-year follow-up could represent a pre-existing trait or a consequence of the illness. Because of the anorexigenic effect of BDNF, it might play an important predisposing role for relapse and should be explored further in studies that test causality., Introduction Patients with anorexia nervosa experience extremely low body weight combined with body image disturbance, drive for thinness, restrictive eating behaviour and often physical hyperactivity. (1) Eating disorders are the [...]

Published
2021
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9. Age dependency of body mass index distribution in childhood and adolescent inpatients with anorexia nervosa with a focus on DSM-5 and ICD-11 weight criteria and severity specifiers

Author

Engelhardt, Christian, Föcker, Manuel, Bühren, Katharina, Dahmen, Brigitte, Becker, Katja, Weber, Linda, Correll, Christoph U., Egberts, Karin Maria, Ehrlich, Stefan, Roessner, Veit, Fleischhaker, Christian, von Gontard, Alexander, Hahn, Freia, Jenetzky, Ekkehart, Kaess, Michael, Legenbauer, Tanja, Renner, Tobias J., Schulze, Ulrike M. E., Sinzig, Judith, Wessing, Ida, Antony, Gisela, Herpertz-Dahlmann, Beate, Peters, Triinu, and Hebebrand, Johannes

Published
2021
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10. Premorbid body weight predicts weight loss in both anorexia nervosa and atypical anorexia nervosa: Further support for a single underlying disorder

Author

Hebebrand, Johannes, primary, Seitz, Jochen, additional, Föcker, Manuel, additional, Viersen, Hanna Preuss‐van, additional, Huss, Michael, additional, Bühren, Katharina, additional, Dahmen, Brigitte, additional, Becker, Katja, additional, Weber, Linda, additional, Correll, Christoph U., additional, Jaite, Charlotte, additional, Egberts, Karin, additional, Romanos, Marcel, additional, Ehrlich, Stefan, additional, Seidel, Maria, additional, Roessner, Veit, additional, Fleischhaker, Christian, additional, Möhler, Eva, additional, Hahn, Freia, additional, Kaess, Michael, additional, Legenbauer, Tanja, additional, Hagmann, Daniela, additional, Renner, Tobias J., additional, Schulze, Ulrike M. E., additional, Thiemann, Ulf, additional, Wessing, Ida, additional, Antony, Gisela, additional, Herpertz‐Dahlmann, Beate, additional, Matthews, Abigail, additional, and Peters, Triinu, additional

Published
2024
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11. Reasons for admission and variance of body weight at referral in female inpatients with anorexia nervosa in Germany

Author

Peters, Triinu, Kolar, David, Föcker, Manuel, Bühren, Katharina, Dahmen, Brigitte, Becker, Katja, Weber, Linda, Correll, Christoph U., Jaite, Charlotte, Egberts, Karin M., Romanos, Marcel, Ehrlich, Stefan, Seidel, Maria, Roessner, Veit, Fleischhaker, Christian, von Gontard, Alexander, Hahn, Freia, Huss, Michael, Kaess, Michael, Legenbauer, Tanja, Renner, Tobias J., Schulze, Ulrike M. E., Sinzig, Judith, Wessing, Ida, Antony, Gisela, Herpertz-Dahlmann, Beate, Gradl-Dietsch, Gertraud, and Hebebrand, Johannes

Published
2021
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12. Modul 5: Theory of Mind – Sprache

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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13. Modul 4: Theory of Mind – Gedanken

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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14. Modul 2: Psychoedukation

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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15. Modul 3: Theory of Mind – Gefühle

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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17. Einzelgespräche

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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19. Dokumentation und Supervision

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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20. Allgemeine Hinweise und Einführung

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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21. Special Events

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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22. Modul 6: Kontaktaufnahme und Freundschaft

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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23. Evaluation im Rahmen der Gruppenstunden

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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24. Evaluation des Therapieprogramms TOMTASS

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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25. Modul 7: Konflikte und Kritik

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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26. Gegenwärtiger Forschungsstand

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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27. Fear Network Unresponsiveness in Women with Anorexia Nervosa

Author

Maier, Simon, Schneider, Katharina, Stark, Carolin, Zeeck, Almut, van Elst, Ludger Tebartz, Holovics, Lukas, Hartmann, Armin, Lahmann, Claas, Domschke, Katharina, Nickel, Kathrin, Feige, Bernd, Glauche, Volkmar, Fleischhaker, Christian, Tüscher, Oliver, and Joos, Andreas

Published
2019

29. Feste Bestandteile

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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30. Weitere Spiele

Author

Paschke-Müller, Mirjam, Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2017
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40. Sitzung 3: Alltagsstrukturierung

Author

Brehm, Bettina, Schill, Judith E., Biscaldi, Monica, Fleischhaker, Christian, Brehm, Bettina, Schill, Judith E., Biscaldi, Monica, and Fleischhaker, Christian

Published
2015
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46. Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial

Author

Frey, Michael, primary, Smigielski, Lukasz, additional, Tini, Elvira, additional, Fekete, Stefanie, additional, Fleischhaker, Christian, additional, Wewetzer, Christoph, additional, Karwautz, Andreas, additional, Correll, Christoph U., additional, Gerlach, Manfred, additional, Taurines, Regina, additional, Plener, Paul L., additional, Malzahn, Uwe, additional, Kornbichler, Selina, additional, Weninger, Laura, additional, Brockhaus, Matthias, additional, Reuter-Dang, Su-Yin, additional, Reitzle, Karl, additional, Rock, Hans, additional, Imgart, Hartmut, additional, Heuschmann, Peter, additional, Unterecker, Stefan, additional, Briegel, Wolfgang, additional, Banaschewski, Tobias, additional, Fegert, Jörg M., additional, Hellenschmidt, Tobias, additional, Kaess, Michael, additional, Kölch, Michael, additional, Renner, Tobias, additional, Rexroth, Christian, additional, Walitza, Susanne, additional, Schulte-Körne, Gerd, additional, Romanos, Marcel, additional, and Egberts, Karin Maria, additional

Published
2023
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47. Therapeutic drug monitoring in adolescents with anorexia nervosa for safe treatment with adjunct olanzapine

Author

Karwautz, Andreas, primary, Zeiler, Michael, additional, Schwarzenberg, Julia, additional, Mairhofer, Dunja, additional, Mitterer, Michaela, additional, Truttmann, Stefanie, additional, Philipp, Julia, additional, Koubek, Doris, additional, Glüder, Maria, additional, Wagner, Gudrun, additional, Malcher, Anouk, additional, Schöfbeck, Gabriele, additional, Laczkovics, Clarissa, additional, Rock, Hans W., additional, Zanko, Annika, additional, Imgart, Hartmut, additional, Banaschewski, Tobias, additional, Fleischhaker, Christian, additional, Correll, Christoph U., additional, Wewetzer, Christoph, additional, Walitza, Susanne, additional, Taurines, Regina, additional, Fekete, Stefanie, additional, Romanos, Marcel, additional, Egberts, Karin, additional, and Gerlach, Manfred, additional

Published
2023
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48. Gegenwärtiger Forschungsstand

Author

Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2013
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49. Modul 5: Theory of Mind – Sprache

Author

Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, Schulz, Eberhard, Paschke-Müller, Mirjam S., Biscaldi, Monica, Rauh, Reinhold, Fleischhaker, Christian, and Schulz, Eberhard

Published
2013
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