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1. Making Sense of Evidence

Author

Wilkinson, K., primary, Boyd, K., additional, Pearson, M., additional, Farrimond, H., additional, Lang, I. A., additional, Fleischer, D., additional, Poole, A., additional, Ralph, N., additional, and Rappert, B., additional

Published
2022
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2. Bidirectional associations between IgE‐mediated food allergy and atopic dermatitis.

Author

Venter, C., Pickett‐Nairne, K., Glueck, D. H., Nevalainen, J., Greenhawt, M., Metsala, J., Sauder, K. A., Perng, W., Fleischer, D. M., Leung, D., and Dabelea, D.

Subjects
MEDICAL terminology, MEDICAL personnel, ELECTRONIC health records, FOOD allergy, MEDICAL history taking, PEANUT allergy, MILK allergy
Abstract

This document summarizes a study on the relationship between atopic dermatitis (AD) and IgE-mediated food allergy (FA) in children. The study found that children with AD were more likely to develop FA, and vice versa. However, the study had limitations, such as not assessing the severity of AD and having a small sample size for cases of FA. The findings suggest that AD and FA may be related and further research is needed to understand and address these conditions. [Extracted from the article]

Published
2024
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6. WAO consensus on definition of food allergy severity (DEFASE)

Author

Arasi, S, Nurmatov, U, Dunn-Galvin, A, Roberts, G, Turner, PJ, Shinder, SB, Gupta, R, Eigenmann, P, Nowak-Wegrzyn, A, Ansotegui, IJ, Rivas, MF, Petrou, S, Tanno, LK, Vazquez-Ortiz, M, Vickery, B, Wong, G, Alvaro-Lozano, M, Asaria, M, Begin, P, Bozzola, M, Boyle, R, Brough, H, Cardona, V, Chinthrajah, RS, Cianferoni, A, Deschildre, A, Fleischer, D, Gazzani, F, Gerdts, J, Giannetti, M, Greenhawt, M, Guzmán, MA, Hossny, E, Kauppi, P, Jones, C, Lucidi, F, Monge Ortega, OP, Munblit, D, Muraro, A, Pajno, G, Podestà, M, Rodriguez del Rio, P, Said, M, Santos, A, Shaker, M, Szajewska, H, Venter, C, Warren, C, Winders, T, Ebisawa, M, and Fiocchi, A

Subjects
Pulmonary and Respiratory Medicine, consensus, definition, food allergy, severity, e-delphi study, RA0421 Public health. Hygiene. Preventive Medicine, Immunology, Immunology and Allergy, R Medicine (General)
Abstract

Background: While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole. Aim: To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. Methods: Phase 1: We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Phase 2: Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from “strongly agree” to “strongly disagree”. Median scores and percentage agreements were calculated. Consensus was defined a priori as being achieved if 70% or more of panel members rated a statement as “strongly agree” to “agree” after the second round. Based on feedback, 2 additional online voting rounds were conducted. Results: We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score. Conclusions: The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.

Published
2023

9. Does Comorbid Food Allergy Affect Response to Omalizumab in Patients with Asthma?

Author

Fiocchi A, Chinthrajah RS, Ansotegui IJ, Sriaroon P, Mustafa SS, Raut P, Cameron B, Gupta S, and Fleischer DM

Subjects
asthma, food allergy, food hypersensitivity, healthcare resource use, omalizumab, productivity, quality of life, Immunologic diseases. Allergy, RC581-607
Abstract

Alessandro Fiocchi,1 R Sharon Chinthrajah,2 Ignacio J Ansotegui,3 Panida Sriaroon,4 S Shahzad Mustafa,5 Pranil Raut,6 Briana Cameron,6 Sachin Gupta,1 David M Fleischer7 1Bambino Gesù Childrens’ Hospital IRCCS, Rome, Italy; 2Stanford University, Stanford, CA, USA; 3Hospital Quironsalud Bizkaia, Bilbao, Spain; 4University of South Florida, Tampa, FL, USA; 5Rochester Regional Health & University of Rochester, Rochester, NY, USA; 6Genentech Inc., South San Francisco, CA, USA; 7Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USACorrespondence: David M Fleischer, Section Head, Allergy & Immunology, University of Colorado School of Medicine and Children’s Hospital Colorado, 13123 East 16th Avenue, B518, Aurora, CO, 80045, USA, Tel +1-720-777-4393, Email David.Fleischer@childrenscolorado.orgBackground: The intrinsic link between food allergy and asthma is well-established, and comorbidity can exacerbate both conditions. Omalizumab, an anti-immunoglobulin E (IgE) antibody, has the biological plausibility to manage both conditions, but only a few small studies have assessed omalizumab in patients with comorbid asthma and food allergy.Patients and Methods: We conducted a post hoc analysis of placebo-controlled, randomized clinical trials (IA05 in children and 008/009 in adolescents/adults) and real-world observational studies (EXCELS and PROSPERO). For each study, patients with asthma were stratified by whether they had physician-reported food allergy, as per baseline characteristics data.Results: For patients with comorbid food allergy, there was evidence for increased atopy at baseline (numerically higher total IgE levels and atopic comorbidities). The collective body of evidence found that omalizumab consistently improved general and asthma-specific patient-centered outcomes (food allergy-specific outcomes were not available). For patients with asthma, omalizumab improved healthcare resource use (emergency room visits, hospitalizations, unscheduled doctor visits), quality of life (asthma-specific Asthma Quality of Life Questionnaire), productivity (missed work/school days and the Work Productivity and Activity Impairment: Asthma), and asthma outcomes (asthma exacerbations and Asthma Control Test score) regardless of comorbid food allergy.Conclusion: There was no loss of omalizumab efficacy even though patients with both asthma and food allergy appeared to be generally more atopic. Omalizumab may be a viable management option for patients with these comorbidities.Clinical trial registration: NCT00079937; NCT01922037; NCT00252135.Plain Language Summary: Food allergy and asthma are linked and if you have both conditions then you can feel worse. There is a treatment available, called omalizumab, that helps people with asthma and helps people with food allergy, but it’s not clear if it can help people with both conditions. Here, we look at whether omalizumab can help people with bad to very bad asthma (also called moderate to severe asthma) who also have food allergy. We found that omalizumab improved many aspects of a person’s life, including whether they visited the emergency room, were admitted to hospital, their quality of life, whether they missed school or work, and whether their asthma improved. These improvements occurred in all people with moderate to severe asthma, whether they had food allergy or did not have food allergy. This suggests that omalizumab can help people with both conditions.Keywords: asthma, food allergy, food hypersensitivity, healthcare resource use, omalizumab, productivity, quality of life

Published
2024

10. International cancer seminars: a focus on esophageal squamous cell carcinoma

Author

Murphy, G., McCormack, V., Abedi-Ardekani, B., Arnold, M., Camargo, M. C., Dar, N. A., Dawsey, S. M., Etemadi, A., Fitzgerald, R. C., Fleischer, D. E., Freedman, N. D., Goldstein, A. M., Gopal, S., Hashemian, M., Hu, N., Hyland, P. L., Kaimila, B., Kamangar, F., Malekzadeh, R., Mathew, C. G., Menya, D., Mulima, G., Mwachiro, M. M., Mwasamwaja, A., Pritchett, N., Qiao, Y.-L., Ribeiro-Pinto, L. F., Ricciardone, M., Schüz, J., Sitas, F., Taylor, P. R., Van Loon, K., Wang, S.-M., Wei, W.-Q., Wild, C. P., Wu, C., Abnet, C. C., Chanock, S. J., and Brennan, P.

Published
2017
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11. MacroBen integrated database on benthic invertebrates of European continental shelves : a tool for large-scale analysis across Europe

Author

Vanden Berghe, E., Claus, S., Appeltans, W., Faulwetter, S., Arvanitidis, C., Somerfield, P. J., Aleffi, I. F., Amouroux, J. M., Anisimova, N., Bachelet, G., Cochrane, S. J., Costello, M. J., Craeymeersch, J., Dahle, S., Degraer, S., Denisenko, S., Dounas, C., Duineveld, G., Emblow, C., Escaravage, V., Fabri, M. C., Fleischer, D., Grémare, A., Herrmann, M., Hummel, H., Karakassis, I., Kędra, M., Kendall, M. A., Kingston, P., Kotwicki, L., Labrune, C., Laudien, J., Nevrova, E. L., Occhipinti-Ambrogi, A., Olsgard, F., Palerud, R., Petrov, A., Rachor, E., Revkov, N., Rumohr, H., Sardá, R., Sistermans, W. C. H., Speybroeck, J., Janas, U., Van Hoey, G., Vincx, M., Whomersley, P., Willems, W., Włodarska-Kowalczuk, M., Zenetos, A., Zettler, M. L., and Heip, C. H. R.

Published
2009

12. Continental-scale patterns in benthic invertebrate diversity : insights from the MacroBen database

Author

Renaud, P. E., Webb, T. J., Bjørgesæter, A., Karakassis, I., Kędra, M., Kendall, M. A., Labrune, C., Lampadariou, N., Somerfield, P. J., Włodarska-Kowalczuk, M., Vanden Berghe, E., Claus, S., Aleffi, I. F., Amouroux, J. M., Bryne, K. H., Cochrane, S. J., Dahle, S., Degraer, S., Denisenko, S. G., Deprez, T., Dounas, C., Fleischer, D., Gil, J., Grémare, A., Janas, U., Mackie, A. S. Y., Palerud, R., Rumohr, H., Sardá, R., Speybroeck, J., Taboada, S., Van Hoey, G., Węsławski, J. M., Whomersley, P., and Zettler, M. L.

Published
2009

13. Macroecology of the European soft sediment benthos : insights from the MacroBen database

Author

Webb, T. J., Aleffi, I. F., Amouroux, J. M., Bachelet, G., Degraer, S., Dounas, C., Fleischer, D., Grémare, A., Herrmann, M., Hummel, H., Karakassis, I., Kędra, M., Kendall, M. A., Kotwicki, L., Labrune, C., Nevrova, E. L., Occhipinti-Ambrogi, A., Petrov, A., Revkov, N. K., Sardá, R., Simboura, N., Speybroeck, J., Van Hoey, G., Vincx, M., Whomersley, P., Willems, W., and Włodarska-Kowalczuk, M.

Published
2009

14. Comparison of the performances of two biotic indices based on the MacroBen database

Author

Grémare, A., Labrune, C., Vanden Berghe, E., Amouroux, J. M., Bachelet, G., Zettler, M. L., Vanaverbeke, J., Fleischer, D., Bigot, L., Maire, O., Deflandre, B., Craeymeersch, J., Degraer, S., Dounas, C., Duineveld, G., Heip, C., Herrmann, M., Hummel, H., Karakassis, I., Kędra, M., Kendall, M., Kingston, P., Laudien, J., Occhipinti-Ambrogi, A., Rachor, E., Sardá, R., Speybroeck, J., Van Hoey, G., Vincx, M., Whomersley, P., Willems, W., Włodarska-Kowalczuk, M., and Zenetos, A.

Published
2009

15. Biological geography of the European seas : results from the MacroBen database

Author

Arvanitidis, C., Somerfield, P. J., Rumohr, H., Faulwetter, S., Valavanis, V., Vasileiadou, A., Chatzigeorgiou, G., Vanden Berghe, E., Vanaverbeke, J., Labrune, C., Grémare, A., Zettler, M. L., Kędra, M., Włodarska-Kowalczuk, M., Aleffi, I. F., Amouroux, J. M., Anisimova, N., Bachelet, G., Büntzow, M., Cochrane, S. J., Costello, M. J., Craeymeersch, J., Dahle, S., Degraer, S., Denisenko, S., Dounas, C., Duineveld, G., Emblow, C., Escavarage, V., Fabri, M. C., Fleischer, D., Gray, J. S., Heip, C. H. R., Herrmann, M., Hummel, H., Janas, U., Karakassis, I., Kendall, M. A., Kingston, P., Kotwicki, L., Laudien, J., Mackie, A. S. Y., Nevrova, E. L., Occhipinti-Ambrogi, A., Oliver, P. G., Olsgard, F., Palerud, R., Petrov, A., Rachor, E., Revkov, N. K., Rose, A., Sardá, R., Sistermans, W. C. H., Speybroeck, J., Van Hoey, G., Vincx, M., Whomersley, P., Willems, W., and Zenetos, A.

Published
2009

17. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants

Author

Fleischer, D. M., Sicherer, S., Greenhawt, M., Campbell, D., Chan, E., Muraro, A., Halken, S., Katz, Y., Ebisawa, M., Eichenfield, L., Sampson, H., Lack, G., Du Toit, G., Roberts, G., Bahnson, H., Feeney, M., Hourihane, J., Spergel, J., Young, M., Asʼaad, A., Allen, K., Prescott, S., Kapur, S., Saito, H., Agache, I., Akdis, C. A., Arshad, H., Beyer, K., Dubois, A., Eigenmann, P., Fernandez-Rivas, M., Grimshaw, K., Hoffman-Sommergruber, K., Host, A., Lau, S., OʼMahony, L., Mills, C., Papadopoulos, N., Venter, C., Agmon-Levin, N., Kessel, A., Antaya, R., Drolet, B., and Rosenwasser, L.

Published
2015
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18. Yield Response of an Ensemble of Potato Crop Models to Elevated CO2 in Continental Europe

Author

Fleischer, D., Condori, B., Barreda, C., Berghuijs, H.N.C., Bindi, M., Boote, K., Craigon, J., van Evert, Frits, Fangmeier, A., Ferrise, R., Gayler, S., Hoogenboom, G., Merante, P., Nendel, C., Ninanya, J., Pleijel, H., Raes, D., Ramirez, D.A., Raymundo, R., Reidsma, P., Silva, J.V., Stöckle, C.O., Supit, Iwan, Stella, T., Vandermeiren, K., van Oort, Pepijn, Vanuytrecht, E., Vorne, V., Wolf, Joost, Fleischer, D., Condori, B., Barreda, C., Berghuijs, H.N.C., Bindi, M., Boote, K., Craigon, J., van Evert, Frits, Fangmeier, A., Ferrise, R., Gayler, S., Hoogenboom, G., Merante, P., Nendel, C., Ninanya, J., Pleijel, H., Raes, D., Ramirez, D.A., Raymundo, R., Reidsma, P., Silva, J.V., Stöckle, C.O., Supit, Iwan, Stella, T., Vandermeiren, K., van Oort, Pepijn, Vanuytrecht, E., Vorne, V., and Wolf, Joost

Abstract

A multi-model inter-comparison study was conducted to evaluate the performance of ten potato crop models to accurately predict potato yield in response to elevated CO2 (Ce) when calibrated with ambient CO2 data (Ca). Experimental data from seven open-top chambers (OTC) and free-air−CO2-enrichment (FACE) facilities across continental Europe were used. Model ensemble percent errors averaged over all datasets for simulated yields were 26.5 % for Ca and 27.2 % Ce data. Metrics such as Wilmott’s index of agreement (IA) and root mean square relative error (RMSRE) ranged broadly among individual models and locations, such that four of the ten models outperformed the median or mean of the ensemble for about half of the Ce datasets. These top performing models were representative of three different model structural groups, including radiation use efficiency, transpiration efficiency, or leaf-level based approaches. Relative response to an increase in CO2 was more accurately modeled than absolute yield responses when averaged across all locations, and within 3.3 kg ppm−1 (or 5%) of observed values. Specific targets in the model structure needed for improvement were not identified due to large and inconsistent variation in the accuracy of yield predictions across locations. However, models with the lowest calibration errors tended to be top performers for Ce predictions as well. Such results suggest calibration is at least as important as model structure. Where possible, modelers using potato models to estimate Ce responses should use Ce calibration data to improve confidence in such predictions.

Published
2021

28. Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett’s esophagus neoplasia with histopathology correlation

Author

Struyvenberg, M R, primary, de Groof, A J, additional, Kahn, A, additional, Weusten, B L A M, additional, Fleischer, D E, additional, Ganguly, E K, additional, Konda, V J A, additional, Lightdale, C J, additional, Pleskow, D K, additional, Sethi, A, additional, Smith, M S, additional, Trindade, A J, additional, Wallace, M B, additional, Wolfsen, H C, additional, Tearney, G J, additional, Meijer, S L, additional, Leggett, C L, additional, Bergman, J J G H M, additional, and Curvers, W L, additional

Published
2020
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47. What is Next? Linking Samples of Planet Earth

Author

Wyborn, L., Lehnert, K., Klump, J., Arko, R., Cox, S., Devaraju, A., Elger, K., Murphy, F., and Fleischer, D.

Abstract

The process of sampling, observing and analyzing physical samples is not unique to the geosciences. Physical sampling (taking specimens) is a fundamental strategy in many natural sciences, typically to support ex-situ observations in laboratories with the goal of characterizing real-world entities or populations. Observations and measurements are made on individual specimens and their derived samples in various ways, with results reported in research publications. Research on an individual sample is often published in numerous articles, based on multiple, potentially unrelated research programs conducted over many years. Even high-volume Earth observation datasets are proxies of real world phenomena and require calibration by measurements made on position located, well described physical samples. Unique, persistent web-compatible identifiers for physical objects and related sampling features are required to ensure their unambiguous citation and connection to related datasets through web identifiers. Identifier systems have been established within specific domains (e.g., bio, geo, hydro) or different sectors (e.g., museums, government agencies, universities), including the International Geo Sample Number (IGSN) in the geosciences, which has been used for rock, fossil, mineral, soil, regolith, fluid, plant and synthetic materials. IGSNs are issued through a governance system that ensures they are globally unique. Each IGSN directs to a digital representation of the physical object via the Handle.net global resolver system, the same system used for resolving DOI. To enable the unique identification of all samples on Planet Earth and of data derived from them, the next step is to ensure IGSNs can either be integrated with comparable identifier systems in other domains/sectors, or introduced into domains that do not have a viable system. A registry of persistent identifier systems for physical samples would allow users to choose which system best suits their needs. Such a registry may also facilitate unifying best practice in these multiple systems to enable consistent referencing of physical samples and of methods used to link digital data to its sources. IGSNs could be extended into other domains, but additional methodologies of sample collection, curation and processing may need to be considered.

Published
2016

50. Incidence of brain metastasis from esophageal cancer

Author

Welch, G., primary, Ross, H. J., additional, Patel, N. P., additional, Jaroszewski, D. E., additional, Fleischer, D. E., additional, Rule, W. G., additional, Paripati, H. R., additional, Ramirez, F. C., additional, and Ashman, J. B., additional

Published
2017
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