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176 results on '"Flehmig, Bertram"'

2. Clinical, genetic, and epidemiological survey of Polish children and adolescents with severe obesity: A study protocol of the Polish–German study project on severe early-onset obesity

Author

Mierzwa, Magdalena, primary, Bik-Multanowski, Mirosław, additional, Ranke, Michael B., additional, Brandt, Stephanie, additional, Flehmig, Bertram, additional, Małecka-Tendera, Ewa, additional, Mazur, Artur, additional, Petriczko, Elżbieta, additional, Wabitsch, Martin, additional, Wójcik, Małgorzata, additional, and Zachurzok, Agnieszka, additional

Published
2022
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4. Long-Term Humoral Immune Response against SARS-CoV-2 after Natural Infection and Subsequent Vaccination According to WHO International Binding Antibody Units (BAU/mL)

Author

Ruetalo, Natalia, primary, Flehmig, Bertram, additional, Schindler, Michael, additional, Pridzun, Lutz, additional, Haage, Angelika, additional, Reichenbächer, Marija, additional, Kirchner, Thomas, additional, Kirchner, Teresa, additional, Klingel, Karin, additional, Ranke, Michael B., additional, and Normann, Andrea, additional

Published
2021
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5. Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Author

Marques, Vanda Afonso, Marta B. Bierig, Nina Duarte-Ramos, Filipa Santos-Laso, Alvaro Jimenez-Aguero, Raul Eizaguirre, Emma Bujanda, Luis Pareja, Maria J. Luis, Rita Costa, Adilia Machado, V, Mariana Alonso, Cristina Arretxe, Enara and Alustiza, Jose M. Krawczyk, Marcin Lammert, Frank and Tiniakos, Dina G. Flehmig, Bertram Cortez-Pinto, Helena and Banales, Jesus M. Castro, Rui E. Normann, Andrea Rodrigues, Cecilia M. P.

Subjects
nutritional and metabolic diseases
Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 serum levels were measured by ELISA in two independent cohorts of biopsy-proven obese NAFLD patients and healthy-liver controls (discovery: 38 NAFLD, 13 controls; validation: 194 NAFLD, 31 controls) and correlated with clinical data, histology, genetic parameters, and serum metabolomics. Results: In both cohorts, leptin increased in NAFLD vs. controls (discovery: AUROC 0.88; validation: AUROC 0.83; p < 0.0001). The leptin levels were similar between obese and non-obese healthy controls, suggesting that obesity is not a confounding factor. In the discovery cohort, adiponectin was lower in non-alcoholic steatohepatitis (NASH) vs. non-alcoholic fatty liver (AUROC 0.87; p < 0.0001). For the validation cohort, significance was attained for homozygous for PNPLA3 allele c.444C (AUROC 0.63; p < 0.05). Combining adiponectin with specific serum lipids improved the assay performance (AUROC 0.80; p < 0.0001). For the validation cohort, IGF-1 was lower with advanced fibrosis (AUROC 0.67, p < 0.05), but combination with international normalized ratio (INR) and ferritin increased the assay performance (AUROC 0.81; p < 0.01). Conclusion: Serum leptin discriminates NAFLD, and adiponectin combined with specific lipids stratifies NASH. IGF-1, INR, and ferritin distinguish advanced fibrosis.

Published
2021

6. Adiponectin, leptin, and IGF-1 are useful diagnostic and stratification biomarkers of NAFLD

Author

Cirugía, radiología y medicina física, Dermatología, oftalmología y otorrinolaringología, Fisiología, Medicina, Dermatologia, oftalmologia eta otorrinolaringologia, Fisiologia, Kirurgia,erradiologia eta medikuntza fisikoa, Medikuntza, Marques, Vanda, Afonso, Marta Bento, Bierig, Nina, Duarte-Ramos, Filipa, Santos Laso, Álvaro, Jiménez Agüero, Raúl, Eizaguirre Letamendia, Emma, Bujanda Fernández de Pierola, Luis, Pareja Megía, María J., Luís, Rita, Costa, Adília, Machado, Mariana Verdelho, Alonso, Cristina, Arretxe Oliden, Enara, Alustiza Echeberria, José María, Krawczyk, Marcin, Lammert, Frank, Tiniakos, Dina G., Flehmig, Bertram, Cortez-Pinto, Helena, Bañales Asurmendi, Jesús María, Castro, Rui E., Normann, Andrea, Rodrigues, Cecilia M. P., Cirugía, radiología y medicina física, Dermatología, oftalmología y otorrinolaringología, Fisiología, Medicina, Dermatologia, oftalmologia eta otorrinolaringologia, Fisiologia, Kirurgia,erradiologia eta medikuntza fisikoa, Medikuntza, Marques, Vanda, Afonso, Marta Bento, Bierig, Nina, Duarte-Ramos, Filipa, Santos Laso, Álvaro, Jiménez Agüero, Raúl, Eizaguirre Letamendia, Emma, Bujanda Fernández de Pierola, Luis, Pareja Megía, María J., Luís, Rita, Costa, Adília, Machado, Mariana Verdelho, Alonso, Cristina, Arretxe Oliden, Enara, Alustiza Echeberria, José María, Krawczyk, Marcin, Lammert, Frank, Tiniakos, Dina G., Flehmig, Bertram, Cortez-Pinto, Helena, Bañales Asurmendi, Jesús María, Castro, Rui E., Normann, Andrea, and Rodrigues, Cecilia M. P.

Abstract

[EN] Background: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 serum levels were measured by ELISA in two independent cohorts of biopsy-proven obese NAFLD patients and healthy-liver controls (discovery: 38 NAFLD, 13 controls; validation: 194 NAFLD, 31 controls) and correlated with clinical data, histology, genetic parameters, and serum metabolomics. Results: In both cohorts, leptin increased in NAFLD vs. controls (discovery: AUROC 0.88; validation: AUROC 0.83; p < 0.0001). The leptin levels were similar between obese and non-obese healthy controls, suggesting that obesity is not a confounding factor. In the discovery cohort, adiponectin was lower in non-alcoholic steatohepatitis (NASH) vs. non-alcoholic fatty liver (AUROC 0.87; p < 0.0001). For the validation cohort, significance was attained for homozygous for PNPLA3 allele c.444C (AUROC 0.63; p < 0.05). Combining adiponectin with specific serum lipids improved the assay performance (AUROC 0.80; p < 0.0001). For the validation cohort, IGF-1 was lower with advanced fibrosis (AUROC 0.67, p<0.05), but combination with international normalized ratio (INR) and ferritin increased the assay performance (AUROC 0.81; p < 0.01). Conclusion: Serum leptin discriminates NAFLD, and adiponectin combined with specific lipids stratifies NASH. IGF-1, INR, and ferritin distinguish advanced fibrosis.

Published
2021

7. Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Author

Marques, Vanda, primary, Afonso, Marta B., additional, Bierig, Nina, additional, Duarte-Ramos, Filipa, additional, Santos-Laso, Álvaro, additional, Jimenez-Agüero, Raul, additional, Eizaguirre, Emma, additional, Bujanda, Luis, additional, Pareja, Maria J., additional, Luís, Rita, additional, Costa, Adília, additional, Machado, Mariana V., additional, Alonso, Cristina, additional, Arretxe, Enara, additional, Alustiza, José M., additional, Krawczyk, Marcin, additional, Lammert, Frank, additional, Tiniakos, Dina G., additional, Flehmig, Bertram, additional, Cortez-Pinto, Helena, additional, Banales, Jesus M., additional, Castro, Rui E., additional, Normann, Andrea, additional, and Rodrigues, Cecília M. P., additional

Published
2021
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8. Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients

Author

Ruetalo, Natalia, primary, Businger, Ramona, additional, Althaus, Karina, additional, Fink, Simon, additional, Ruoff, Felix, additional, Pogoda, Michaela, additional, Iftner, Angelika, additional, Ganzenmüller, Tina, additional, Hamprecht, Klaus, additional, Flehmig, Bertram, additional, Bakchoul, Tamam, additional, Templin, Markus F., additional, and Schindler, Michael, additional

Published
2021
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10. Longitudinal analysis of virus load, serum antibody levels and virus neutralizing activity in vitro in cases with less severe COVID-19

Author

Flehmig, Bertram, primary, Schindler, Michael, additional, Ruetalo, Natalia, additional, Businger, Ramona, additional, Bayer, Manfred, additional, Haage, Angelika, additional, Kirchner, Thomas, additional, Klingel, Karin, additional, Normann, Andrea, additional, Pridzun, Lutz, additional, Tougianidou, Despina, additional, and Ranke, Michael B., additional

Published
2020
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12. Relative leptin deficiency in children with severe early-onset obesity (SEOO) – results of the Early-onset Obesity and Leptin – German-Polish Study (EOL-GPS)

Author

Zachurzok, Agnieszka, primary, Ranke, Michael B., additional, Flehmig, Bertram, additional, Jakubek-Kipa, Katarzyna, additional, Marcinkiewicz, Katarzyna, additional, Mazur, Artur, additional, Petriczko, Elzbieta, additional, Pridzun, Lutz, additional, von Schnurbein, Julia, additional, Walczak, Mieczyslaw, additional, Malecka-Tendera, Ewa, additional, Wabitsch, Martin, additional, and Brandt, Stephanie, additional

Published
2020
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13. Detecion of Hepatitis A virus in sewage sludge by antigen capture Polymerase Chain reaction

Author

Graff, Judith, Ticehurst, John, and Flehmig, Bertram

Subjects
Hepatitis A virus -- Identification and classification, Polymerase chain reaction -- Usage, Sewage sludge -- Observations, Biological sciences
Abstract

The use of antigen capture polymerase chain reaction (PCR) facilitates the quick and effective discovery of hepatitis A Virus (HAV) in sewage sludge. The presence of solid-phase virus-catching monoclonal antibodies in the antigen capture PCR method produces the same result as those produced during its absence. Comparison of this method with another method using indirect immunofluorescence after cell culture inoculation reveals that the antigen capture PCR technique is advantageous as results are obtained within two days.

Published
1993

16. Hepatitis G virus infection

Author

Schleicher, Sabine, Normann, Andrea, Gregor, Michael, Hess, Georg, and Flehmig, Bertram

Published
1997

17. Simultaneous vaccination for hepatitis A and

Author

Flehmig, Bertram, Heinricy, Ursula, and Pfisterer, Mechthild

Subjects
Immunization -- Evaluation, Hepatitis A -- Prevention, Hepatitis, Viral -- Prevention, Hepatitis B -- Prevention, Health
Abstract

Hepatitis B has been the primary focus of immunization campaigns against hepatitis. Since hepatitis B can lead to chronic liver disease, cirrhosis, and liver cancer, it is a more serious threat to public health than is hepatitis A. However, since immunity to hepatitis A is falling in industrial countries, an increasingly large segment of the population is becoming susceptible to this disease. Therefore, there is some rationale for the use of a combined vaccine, so that patients may be immunized against hepatitis A and B at the same time. A combination vaccine was prepared by mixing killed hepatitis A virus with a commercially available vaccine consisting of hepatitis B surface antigen (HBsAg). Fifteen volunteers without hepatitis antibodies were inoculated three times, at one-month intervals. Measurement of the serum antibodies elicited by this vaccine revealed that the level of antibodies against hepatitis A was higher among subjects injected with the combination vaccine than among patients who were vaccinated against hepatitis A alone; this difference became less pronounced by 48 weeks after the first injection, however. Of the 15 subjects, 14 developed satisfactory levels of antibodies against hepatitis B after the series of injections. Eleven volunteers were tested after 48 weeks, and were found to still have high titers of antibodies against both hepatitis A and B at that time. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

18. A Novel Marsupial Hepatitis A Virus Corroborates Complex Evolutionary Patterns Shaping the Genus Hepatovirus

Author

de Oliveira Carneiro, Ianei, primary, Sander, Anna-Lena, additional, Silva, Namá, additional, Moreira-Soto, Andres, additional, Normann, Andrea, additional, Flehmig, Bertram, additional, Lukashev, Alexander N., additional, Dotzauer, Andreas, additional, Wieseke, Nicolas, additional, Franke, Carlos Roberto, additional, and Drexler, Jan Felix, additional

Published
2018
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23. Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency

Author

Wabitsch, Martin, primary, Pridzun, Lutz, additional, Ranke, Michael, additional, von Schnurbein, Julia, additional, Moss, Anja, additional, Brandt, Stephanie, additional, Kohlsdorf, Katja, additional, Moepps, Barbara, additional, Schaab, Michael, additional, Funcke, Jan-Bernd, additional, Gierschik, Peter, additional, Fischer-Posovszky, Pamela, additional, Flehmig, Bertram, additional, and Kratzsch, Jürgen, additional

Published
2017
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30. Acute hepatitis A virus infection in Turkey

Author

Normann, Andrea, primary, Badur, Selim, additional, Önel, Derya, additional, Kilic, Ayse, additional, Sidal, Müjgan, additional, Larouzé, Bernard, additional, Massari, Veronique, additional, Müller, Julia, additional, and Flehmig, Bertram, additional

Published
2008
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