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174 results on '"Flapan, Andrew D"'

2. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

Author

Joshi, Nikhil V, Vesey, Alex T, Williams, Michelle C, Shah, Anoop S V, Calvert, Patrick A, Craighead, Felicity H M, Yeoh, Su Ern, Wallace, William, Salter, Donald, Fletcher, Alison M, van Beek, Edwin J R, Flapan, Andrew D, Uren, Neal G, Behan, Miles W H, Cruden, Nicholas L M, Mills, Nicholas L, Fox, Keith A A, Rudd, James H F, Dweck, Marc R, and Newby, David E

Published
2014
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5. Navigating premature rupture of the expandable sheath delivery system during elective transfemoral transcatheter aortic valve implantation: a case report.

Author

Chapman, Andrew R, Russell-Dalton, Anastasia, Holland, James, and Flapan, Andrew D

Abstract

Background Transcatheter aortic valve implantation (TAVI) has revolutionised the treatment of severe aortic stenosis, but is still associated with a risk of major vascular complication. Case summary An elective transfemoral TAVI was undertaken for severe aortic stenosis. During delivery of a 26mm Sapien S3 valve, the delivery system sheath (eSheath) split prematurely. The valve could not be advanced, and lay parallel to the sheath body. Following advice, an attempt was made to remove the system en bloc but this was unsuccessful. After careful consideration of alternative options, the valve was advanced with reasonable force and the case was completed successfully. The femoral artery was closed with parclose sutures without major vascular complication. Discussion Early recognition of a split sheath with effective communication between lab team members and the manufacturer allowed us to successfully navigate this case, with a good outcome for our patient. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Authors' reply

Author

Din, Jehangir N, Newby, David E, and Flapan, Andrew D

Published
2004

11. Effects of a brief course of azithromycin on soluble cell adhesion molecules and markers of inflammation in survivors of an acute coronary syndrome: a double-blind, randomized, placebo-controlled study

Author

Hillis, Graham S., Pearson, Claire V., Harding, Scott A., Sutherland, Sheena, Ludlam, Christopher A., Marioni, John C., Prescott, Robin J., Fox, Keith A.A., and Flapan, Andrew D.

Subjects
Pneumonia -- Drug therapy, Bacterial pneumonia -- Drug therapy, Coronary heart disease -- Drug therapy, Azithromycin -- Dosage and administration, Azithromycin -- Chemical properties, Cardiac patients -- Case studies, Clinical trials, Health
Published
2004

14. Determinants and prognostic value of echocardiographic first-phase ejection fraction in aortic stenosis

Author

Bing, Rong, primary, Gu, Haotian, additional, Chin, Calvin, additional, Fang, Lingyun, additional, White, Audrey, additional, Everett, Russell J, additional, Spath, Nicholas B, additional, Park, Eunsoo, additional, Jenkins, William SA, additional, Shah, Anoop SV, additional, Mills, Nicholas L, additional, Flapan, Andrew D, additional, Chambers, John B, additional, Newby, David E, additional, Chowienczyk, Phil, additional, and Dweck, Marc R, additional

Published
2020
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16. LETTER TO THE EDITOR

Author

Lang, Christopher, Flapan, Andrew D., and Neilson, James

Published
2004

22. Scandinavian simvastatin study (4S)

Author

Wright, Robert A, Flapan, Andrew D, Pedersen, Terje R, Kjekshus, John, Olsson, Anders G, Berg, Kare, Faergeman, Ole, Haghfelt, Torben, Miettinen, Tatu, Pyorala, Kalevi, Thorgeirsson, Gudmundur, Wedel, Hans, and Wilhelmsen, Lars

Published
1994

24. Management of patients after their first myocardial infarction

Author

Flapan, Andrew D.

Subjects
Heart attack -- Care and treatment, Coronary heart disease -- Prognosis, Cardiac patients -- Care and treatment
Abstract

In the past 20 years there has been a steady improvement in the short term prognosis of patients with myocardial infarction,(1) following the introduction of [beta] blockers, thrombolysis, and aspirin. […]

Published
1994

25. Role of transesophageal echocardiography in diagnosis and management of central pulmonary artery thromboembolism

Author

Rittoo, Dylmitr, Sutherland, George R., Samuel, Leslie, Flapan, Andrew D., and Shaw, Thomas R.D.

Subjects
Transesophageal echocardiography, Pulmonary artery, Thromboembolism -- Diagnosis, Health
Abstract

Acute pulmonary embolism is a potentially fatal condition. Untreated, it carries a 30% hospital mortality rate.[1] It may be difficult to diagnose because currently available noninvasive techniques including ventilation/perfusion scanning cannot establish or exclude the diagnosis reliably in most patients suspected of pulmonary embolism.[2] Direct visualization of the central pulmonary arteries is possible with the use of transesophageal echocardiography (TEE).[3] Although TEE, mostly single plane, is now widely used in clinical practice, its role in the assessment of patients suspected of pulmonary thromboembolism has not been well documented. Five cases are presented to demonstrate the value of biplane TEE in patients with different clinical manifestations of pulmonary thromboembolic disease.

Published
1993

26. A 59-year-old woman with visible precordial pulsations

Author

Moss, Alastair J, Pessotto, Renzo, and Flapan, Andrew D

Subjects
cardiovascular system, Journal Article
Abstract

CLINICAL INTRODUCTION: A retired 59-year-old woman presented to the cardiology clinic concerned with cardiac pulsations that were visible on her chest wall. These were not associated with dyspnoea, syncope or chest discomfort.Of note, 8 years previously, she complained of recurrent nocturnal diaphoresis and 5 kg weight loss. Blood sampling at that time revealed a microcytic anaemia, reactive thrombocytosis and raised inflammatory markers (erythrocyte sedimentation rate 99 mm/hour, C-reactive protein 161 mg/L). Following an episode of transient diplopia, ophthalmoscopy demonstrated a cotton wool spot in the left inferotemporal retinal arcade. She commenced a 2-year tapering course of 1 mg/kg prednisolone.On examination, she had a lean physique with a supine blood pressure of 162/60 mm Hg and palpable Corrigan's pulse. She had a prominent apical pulsation and a loud early diastolic murmur was present at the left sternal edge radiating to the apex. Echocardiography showed severe central aortic regurgitation and a dilated aortic root (see online supplementary figure 1). Cardiac CT was performed to clarify the diagnosis (figure 1).heartjnl;heartjnl-2017-312193v1/F1F1F1Figure 1Contrast-enhanced CT of the thorax at index presentation (A) and 6 months (B). Prospective ECG-gated cardiac CT angiogram (75% R-R interval) performed at 8 years from index presentation (C) with a stretched multiplanar reconstruction of the aortic annulus, aortic root and thoracic aorta (D).DC1SP110.1136/heartjnl-2017-312193.supp1Supplementary file 1.

Published
2017
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27. Effect of captopril on cardiac parasympathetic activity in chronic cardiac failure secondary to coronary artery disease

Author

Flapan, Andrew D., Nolan, James, Neilson, James M.M., and Ewing, David J.

Subjects
Captopril -- Health aspects, Heart failure -- Drug therapy, Coronary heart disease -- Drug therapy, Nervous system, Parasympathetic -- Drug therapy, Health
Abstract

Thirty-two patients with chronic cardiac failure underwent 24-hour ambulatory electrocardiographic monitoring on 2 separate occasions: 20 patients before and during treatment with captopril, and 12 acting as controls. Heart rate variability was calculated by counting the number of times successive RR internal differences were >50 ms (this measurement being a reliable index of cardiac parasympathetic activity). During treatment with captopril, group mean total counts increased to 1,032 (range 48 to 7,437) from 482 (range 23 to 6,120) (p = 0.002). There was no change in mean hourly waking or sleeping heart rates. In the control group, no changes were seen: group mean total counts on the first occasion were 340 (range 120 to 3,255) and on the second occasion 400 (range 154 to 3,300) (p = not significant). These results show that treatment with angiotensin-converting enzyme inhibitors increases cardiac parasympathetic activity in patients with chronic cardiac failure. This may be relevant to the improved prognosis of this group of patients when treated with antiotension-converting enzyme inhibitors.

Published
1992

28. Determinants and prognostic value of echocardiographic first-phase ejection fraction in aortic stenosis.

Author

Rong Bing, Haotian Gu, Chin, Calvin, Lingyun Fang, White, Audrey, Everett, Russell J., Spath, Nicholas B., Eunsoo Park, Jenkins, William S. A., Shah, Anoop S. V., Mills, Nicholas L., Flapan, Andrew D., Chambers, John B., Newby, David E., Chowienczyk, Phil, Dweck, Marc R., Bing, Rong, Gu, Haotian, Fang, Lingyun, and Park, Eunsoo

Subjects
AORTIC stenosis, AORTIC valve transplantation, MAGNETIC resonance, AORTIC coarctation, LEFT heart ventricle, ECHOCARDIOGRAPHY, RESEARCH, MYOCARDIUM, PREDICTIVE tests, RESEARCH methodology, PROGNOSIS, RETROSPECTIVE studies, FIBROSIS, MAGNETIC resonance imaging, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, HEMODYNAMICS, STROKE volume (Cardiac output), HEART physiology, AORTIC valve
Abstract

Objective: First-phase ejection fraction (EF1) is a novel measure of early left ventricular systolic dysfunction. We investigated determinants of EF1 and its prognostic value in aortic stenosis.Methods: EF1 was measured retrospectively in participants of an echocardiography/cardiovascular magnetic resonance cohort study which recruited patients with aortic stenosis (peak aortic velocity of ≥2 m/s) between 2012 and 2014. Linear regression models were constructed to examine variables associated with EF1. Cox proportional hazards were used to determine the prognostic power of EF1 for aortic valve replacement (AVR, performed as part of clinical care in accordance with international guidelines) or death.Results: Total follow-up of the 149 participants (69.8% male, 70 (65-76) years, mean gradient 33 (21-42) mm Hg) was 238 029 person-days. Sixty-seven participants (45%) had a low baseline EF1 (<25%) despite normal ejection fraction (67% (62%-71%)). Patients with low EF1 had more severe aortic stenosis (mean gradient 39 (34-45) mm Hg vs 24 (16-35) mm Hg, p<0.001) and more myocardial fibrosis (indexed extracellular volume (iECV) (24.2 (19.6-28.7) mL/m2 vs 20.6 (16.8-24.3) mL/m2, p=0.002; late gadolinium enhancement (LGE) prevalence 52% vs 20%, p<0.001). Zva, iECV and infarct LGE were independent predictors of EF1. EF1 improved post-AVR (n=57 with post-AVR EF1 available, baseline 16 (12-24) vs follow-up 27% (22%-31%); p<0.001). Low baseline EF1 was an independent predictor of AVR/death (HR 5.6, 95% CI 3.4 to 9.4), driven by AVR.Conclusion: EF1 quantifies early, potentially reversible systolic dysfunction in aortic stenosis, is associated with global afterload and myocardial fibrosis, and is an independent predictor of AVR. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Fire Simulation and Cardiovascular Health in Firefighters

Author

Hunter, Amanda L., primary, Shah, Anoop S.V., additional, Langrish, Jeremy P., additional, Raftis, Jennifer B., additional, Lucking, Andrew J., additional, Brittan, Mairi, additional, Venkatasubramanian, Sowmya, additional, Stables, Catherine L., additional, Stelzle, Dominik, additional, Marshall, James, additional, Graveling, Richard, additional, Flapan, Andrew D., additional, Newby, David E., additional, and Mills, Nicholas L., additional

Published
2017
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34. Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Author

Hunter, Amanda, Unosson, Jon, Bosson, Jenny A, Langrish, Jeremy P, Pourazar, Jamshid, Raftis, Jennifer B, Miller, Mark R, Lucking, Andrew J, Boman, Christoffer, Nyström, Robin, Donaldson, Kenneth, Flapan, Andrew D, Pung, Louis, Sadiktsis, Ioannis, Masala, Silvia, Westerholm, Roger, Sandström, Thomas, Blomberg, Anders, Newby, David E, Mills, Nicholas L, Hunter, Amanda, Unosson, Jon, Bosson, Jenny A, Langrish, Jeremy P, Pourazar, Jamshid, Raftis, Jennifer B, Miller, Mark R, Lucking, Andrew J, Boman, Christoffer, Nyström, Robin, Donaldson, Kenneth, Flapan, Andrew D, Pung, Louis, Sadiktsis, Ioannis, Masala, Silvia, Westerholm, Roger, Sandström, Thomas, Blomberg, Anders, Newby, David E, and Mills, Nicholas L

Abstract

Background: Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure on vascular vasomotor and fibrinolytic function, and thrombus formation in healthy fire fighters. Methods: In a double-blind randomized cross-over study, 16 healthy male fire fighters were exposed to wood smoke (~1 mg/m3 particulate matter concentration) or filtered air for one hour during intermittent exercise. Arterial pressure and stiffness were measured before and immediately after exposure, and forearm blood flow was measured during intra-brachial infusion of endothelium-dependent and -independent vasodilators 4–6 hours after exposure. Thrombus formation was assessed using the ex vivo Badimon chamber at 2 hours, and platelet activation was measured using flow cytometry for up to 24 hours after the exposure. Results: Compared to filtered air, exposure to wood smoke increased blood carboxyhaemoglobin concentrations (1.3% versus 0.8%; P < 0.001), but had no effect on arterial pressure, augmentation index or pulse wave velocity (P > 0.05 for all). Whilst there was a dose-dependent increase in forearm blood flow with each vasodilator (P < 0.01 for all), there were no differences in blood flow responses to acetylcholine, sodium nitroprusside or verapamil between exposures (P > 0.05 for all). Following exposure to wood smoke, vasodilatation to bradykinin increased (P = 0.003), but there was no effect on bradykinin-induced tissue-plasminogen activator release, thrombus area or markers of platelet activation (P > 0.05 for all). Conclusions: Wood smoke exposure does not impair vascular vasomotor or fibrinolytic function, or increase thrombus formation in fire fighters. Acute cardiovascular events following fire suppression may be precipitated by exposure to other air pollutants or through other mechanisms, such as strenuous physical exert, Originally included in thesis in manuscript form.

Published
2014
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36. Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Author

Hunter, Amanda L, primary, Unosson, Jon, additional, Bosson, Jenny A, additional, Langrish, Jeremy P, additional, Pourazar, Jamshid, additional, Raftis, Jennifer B, additional, Miller, Mark R, additional, Lucking, Andrew J, additional, Boman, Christoffer, additional, Nyström, Robin, additional, Donaldson, Kenneth, additional, Flapan, Andrew D, additional, Shah, Anoop SV, additional, Pung, Louis, additional, Sadiktsis, Ioannis, additional, Masala, Silvia, additional, Westerholm, Roger, additional, Sandström, Thomas, additional, Blomberg, Anders, additional, Newby, David E, additional, and Mills, Nicholas L, additional

Published
2014
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40. Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial

Author

Newby, David E, primary, Williams, Michelle C, additional, Flapan, Andrew D, additional, Forbes, John F, additional, Hargreaves, Allister D, additional, Leslie, Stephen J, additional, Lewis, Steff C, additional, McKillop, Graham, additional, McLean, Scott, additional, Reid, John H, additional, Sprat, James C, additional, Uren, Neal G, additional, van Beek, Edwin J, additional, Boon, Nicholas A, additional, Clark, Liz, additional, Craig, Peter, additional, Flather, Marcus D, additional, McCormack, Chiara, additional, Roditi, Giles, additional, Timmis, Adam D, additional, Krishan, Ashma, additional, Donaldson, Gillian, additional, Fotheringham, Marlene, additional, Hall, Fiona J, additional, Neary, Paul, additional, Cram, Louisa, additional, Perkins, Sarah, additional, Taylor, Fiona, additional, Eteiba, Hany, additional, Rae, Alan P, additional, Robb, Kate, additional, Barrie, Dawn, additional, Bissett, Kim, additional, Dawson, Adelle, additional, Dundas, Scot, additional, Fogarty, Yvonne, additional, Ramkumar, Prasad Guntur, additional, Houston, Graeme J, additional, Letham, Deborah, additional, O’Neill, Linda, additional, Pringle, Stuart D, additional, Ritchie, Valerie, additional, Sudarshan, Thiru, additional, Weir-McCall, Jonathan, additional, Cormack, Alistair, additional, Findlay, Iain N, additional, Hood, Stuart, additional, Murphy, Clare, additional, Peat, Eileen, additional, Allen, Barbara, additional, Baird, Andrew, additional, Bertram, Danielle, additional, Brian, David, additional, Cowan, Amy, additional, Cruden, Nicholas L, additional, Dweck, Marc R, additional, Flint, Laura, additional, Fyfe, Samantha, additional, Keanie, Collette, additional, MacGillivray, Tom J, additional, Maclachlan, David S, additional, MacLeod, Margaret, additional, Mirsadraee, Saeed, additional, Morrison, Avril, additional, Mills, Nicholas L, additional, Minns, Fiona C, additional, Phillips, Alyson, additional, Queripel, Laura J, additional, Weir, Nicholas W, additional, Bett, Fiona, additional, Divers, Frances, additional, Fairley, Katie, additional, Jacob, Ashok J, additional, Keegan, Edith, additional, White, Tricia, additional, Gemmill, John, additional, Henry, Margo, additional, McGowan, James, additional, Dinnel, Lorraine, additional, Francis, C Mark, additional, Sandeman, Dennis, additional, Yerramasu, Ajay, additional, Berry, Colin, additional, Boylan, Heather, additional, Brown, Ammani, additional, Duffy, Karen, additional, Frood, Alison, additional, Johnstone, Janet, additional, Lanaghan, Kirsten, additional, MacDuff, Ross, additional, MacLeod, Martin, additional, McGlynn, Deborah, additional, McMillan, Nigel, additional, Murdoch, Laura, additional, Noble, Colin, additional, Paterson, Victoria, additional, Steedman, Tracey, additional, and Tzemos, Nikolaos, additional

Published
2012
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43. Percutaneous Coronary Intervention in the Elderly

Author

Johnman, Cathy, primary, Oldroyd, Keith G., additional, Mackay, Danny F., additional, Slack, Rachel, additional, Pell, Alastair C.H., additional, Flapan, Andrew D., additional, Jennings, Kevin P., additional, Eteiba, Hany, additional, Irving, John, additional, and Pell, Jill P., additional

Published
2010
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46. Vascular Effects of Apelin In Vivo in Man

Author

Japp, Alan G., primary, Cruden, Nicholas L., additional, Amer, David A.B., additional, Li, Vivienne K.Y., additional, Goudie, Ewan B., additional, Johnston, Neil R., additional, Sharma, Sushma, additional, Neilson, Ilene, additional, Webb, David J., additional, Megson, Ian L., additional, Flapan, Andrew D., additional, and Newby, David E., additional

Published
2008
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47. Drug-Eluting Stents Versus Bare-Metal Stents for Off-Label Indications

Author

Austin, David, primary, Oldroyd, Keith G., additional, McConnachie, Alex, additional, Slack, Rachel, additional, Eteiba, Hany, additional, Flapan, Andrew D., additional, Jennings, Kevin P., additional, Northcote, Robin J., additional, Pell, Alastair C.H., additional, Starkey, Ian R., additional, and Pell, Jill P., additional

Published
2008
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