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2. Radiomics of Intrahepatic Cholangiocarcinoma and Peritumoral Tissue Predicts Postoperative Survival: Development of a CT-Based Clinical-Radiomic Model

Author

Fiz, Francesco, Rossi, Noemi, Langella, Serena, Conci, Simone, Serenari, Matteo, Ardito, Francesco, Cucchetti, Alessandro, Gallo, Teresa, Zamboni, Giulia A., Mosconi, Cristina, Boldrini, Luca, Mirarchi, Mariateresa, Cirillo, Stefano, Ruzzenente, Andrea, Pecorella, Ilaria, Russolillo, Nadia, Borzi, Martina, Vara, Giulio, Mele, Caterina, Ercolani, Giorgio, Giuliante, Felice, Cescon, Matteo, Guglielmi, Alfredo, Ferrero, Alessandro, Sollini, Martina, Chiti, Arturo, Torzilli, Guido, Ieva, Francesca, and Viganò, Luca

Published
2024
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4. ASO Visual Abstract: Radiomics of Intrahepatic Cholangiocarcinoma and Peritumoral Tissue Predicts Postoperative Survival: Development of a CT-Based Clinical-Radiomic Model

Author

Fiz, Francesco, Rossi, Noemi, Langella, Serena, Conci, Simone, Serenari, Matteo, Ardito, Francesco, Cucchetti, Alessandro, Gallo, Teresa, Zamboni, Giulia A., Mosconi, Cristina, Boldrini, Luca, Mirarchi, Mariateresa, Cirillo, Stefano, Ruzzenente, Andrea, Pecorella, Ilaria, Russolillo, Nadia, Borzi, Martina, Vara, Giulio, Mele, Caterina, Ercolani, Giorgio, Giuliante, Felice, Cescon, Matteo, Guglielmi, Alfredo, Ferrero, Alessandro, Sollini, Martina, Chiti, Arturo, Torzilli, Guido, Ieva, Francesca, and Viganò, Luca

Published
2024
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6. The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy

Author

Piccardo, Arnoldo, Treglia, Giorgio, Fiz, Francesco, Bar-Sever, Zvi, Bottoni, Gianluca, Biassoni, Lorenzo, Borgwardt, Lise, de Keizer, Bart, Jehanno, Nina, Lopci, Egesta, Kurch, Lars, Massollo, Michela, Nadel, Helen, Roca Bielsa, Isabel, Shulkin, Barry, Vali, Reza, De Palma, Diego, Cecchin, Diego, Santos, Ana Isabel, and Zucchetta, Pietro

Published
2024
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8. Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with 18F-fluoroestradiol (18F-FES) CT/PET

Author

Malagutti, Bianca, Dib, Bassam, Branni, Carmen, D’Amico, Mauro, Provinciali, Nicoletta, Corradengo, Davide, Fiz, Francesco, Iacozzi, Massimiliano, Rocca, Andrea, Gennari, A., Brain, E., De Censi, A., Nanni, O., Wuerstlein, R., Frassoldati, A., Cortes, J., Rossi, V., Palleschi, M., Alberini, J.L., Matteucci, F., Piccardo, A., Sacchetti, G., Ilhan, H., D’Avanzo, F., Ruffilli, B., Nardin, S., Monti, M., Puntoni, M., Fontana, V., Boni, L., and Harbeck, N.

Published
2024
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11. Diagnostic and Dosimetry Features of [64Cu]CuCl2 in High-Grade Paediatric Infiltrative Gliomas

Author

Fiz, Francesco, Bottoni, Gianluca, Ugolini, Martina, Righi, Sergio, Cirone, Alessio, Garganese, Maria Carmen, Verrico, Antonio, Rossi, Andrea, Milanaccio, Claudia, Ramaglia, Antonia, Mastronuzzi, Angela, Abate, Massimo Eraldo, Cacchione, Antonella, Gandolfo, Carlo, Colafati, Giovanna Stefania, Garrè, Maria Luisa, Morana, Giovanni, and Piccardo, Arnoldo

Published
2023
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12. Diagnostic effectiveness of [18F]Fluoroestradiol PET/CT in oestrogen receptor-positive breast cancer: the key role of histopathology. Evidence from an international multicentre prospective study

Author

Bottoni, Gianluca, Fiz, Francesco, Puntoni, Matteo, Matteucci, Federica, Monti, Manuela, DeCensi, Andrea, Nanni, Oriana, Brain, Etienne, Alberini, Jean Louis, Dib, Bassam, Sacchetti, Gianmauro, Trimboli, Pierpaolo, Treglia, Giorgio, Harbeck, Nadia, Sola, Simona, Gennari, Alessandra, and Piccardo, Arnoldo

Published
2023
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14. Automated Definition of Skeletal Disease Burden in Metastatic Prostate Carcinoma: a 3D analysis of SPECT/CT images

Author

Fiz, Francesco, Dittmann, Helmut, Campi, Cristina, Weissinger, Matthias, Sahbai, Samine, Reimold, Matthias, Stenzl, Arnulf, Piana, Michele, Sambuceti, Gianmario, and la Fougère, Christian

Subjects
Quantitative Biology - Tissues and Organs, Computer Science - Computer Vision and Pattern Recognition, 92C55, 92C50, 68U10
Abstract

To meet the current need for skeletal tumor-load estimation in prostate cancer (mCRPC), we developed a novel approach, based on adaptive bone segmentation. In this study, we compared the program output with existing estimates and with the radiological outcome. Seventy-six whole-body 99mTc-DPD-SPECT/CT from mCRPC patients were analyzed. The software identified the whole skeletal volume (SVol) and classified it voxels metastases (MVol) or normal bone (BVol). SVol was compared with the estimation of a commercial software. MVol was compared with manual assessment and with PSA-level. Counts/voxel were extracted from MVol and BVol. After six cycles of 223RaCl2-therapy every patient was re-evaluated as progressing (PD), stabilized (SD) or responsive (PR). SVol correlated with the one of the commercial software (R=0,99, p<0,001). MVol correlated with manually-counted lesions (R=0,61, p<0,001) and PSA (R=0,46, p<0.01). PD had a lower counts/voxel in MVol than PR/SD (715 \pm 190 Vs. 975 \pm 215 and 1058 \pm 255, p<0,05 and p<0,01) and in BVol (PD 275 \pm 60, PR 515 \pm 188 and SD 528 \pm 162 counts/voxel, p<0,001). Segmentation-based tumor load correlated with radiological/laboratory indices. Uptake was linked with the clinical outcome, suggesting that metastases in PD patients have a lower affinity for bone-seeking radionuclides and might benefit less from bone-targeted radioisotope therapies.

Published
2019

19. Role of 64CuCl2 PET/CT in Detecting and Staging Muscle-Invasive Bladder Cancer: Comparison with Contrast-Enhanced CT and 18F-FDG PET/CT.

Author

Piccardo, Arnoldo, Bottoni, Gianluca, Puppo, Cristina, Massollo, Michela, Ugolini, Martina, Naseri, Mehrdad Shoushtari Zadeh, Melani, Enrico, Tomasello, Laura, Boitano, Monica, DeCensi, Andrea, Sambucco, Beatrice, Campodonico, Fabio, Altrinetti, Vania, Ennas, Marco, Urru, Alessia, Augusto Negro, Carlo Luigi, Timossi, Luca, Treglia, Giorgio, Introini, Carlo, and Fiz, Francesco

Published
2024
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20. Radiomic Gradient in Peritumoural Tissue of Liver Metastases: A Biomarker for Clinical Practice? Analysing Density, Entropy, and Uniformity Variations with Distance from the Tumour.

Author

Fiz, Francesco, Ragaini, Elisa Maria, Sirchia, Sara, Masala, Chiara, Viganò, Samuele, Francone, Marco, Cavinato, Lara, Lanzarone, Ettore, Ammirabile, Angela, and Viganò, Luca

Subjects
*COLORECTAL liver metastasis, *LIVER tumors, *SURGICAL margin, *COMPUTED tomography, *ONCOLOGIC surgery
Abstract

The radiomic analysis of the tissue surrounding colorectal liver metastases (CRLM) enhances the prediction accuracy of pathology data and survival. We explored the variation of the textural features in the peritumoural tissue as the distance from CRLM increases. We considered patients with hypodense CRLMs >10 mm and high-quality computed tomography (CT). In the portal phase, we segmented (1) the tumour, (2) a series of concentric rims at a progressively increasing distance from CRLM (from one to ten millimetres), and (3) a cylinder of normal parenchyma (Liver-VOI). Sixty-three CRLMs in 51 patients were analysed. Median peritumoural HU values were similar to Liver-VOI, except for the first millimetre around the CRLM. Entropy progressively decreased (from 3.11 of CRLM to 2.54 of Liver-VOI), while uniformity increased (from 0.135 to 0.199, p < 0.001). At 10 mm from CRLM, entropy was similar to the Liver-VOI in 62% of cases and uniformity in 46%. In small CRLMs (≤30 mm) and responders to chemotherapy, normalisation of entropy and uniformity values occurred in a higher proportion of cases and at a shorter distance. The radiomic analysis of the parenchyma surrounding CRLMs unveiled a wide halo of progressively decreasing entropy and increasing uniformity despite a normal radiological aspect. Underlying pathology data should be investigated. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Introduction to PET

Author

Fiz, Francesco, primary, Ugolini, Martina, additional, Milan, Lisa, additional, Giovanella, Luca, additional, and Piccardo, Arnoldo, additional

Published
2022
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26. Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with 18F-fluoroestradiol (18F-FES) CT/PET

Author

Gennari, A., primary, Brain, E., additional, De Censi, A., additional, Nanni, O., additional, Wuerstlein, R., additional, Frassoldati, A., additional, Cortes, J., additional, Rossi, V., additional, Palleschi, M., additional, Alberini, J.L., additional, Matteucci, F., additional, Piccardo, A., additional, Sacchetti, G., additional, Ilhan, H., additional, D’Avanzo, F., additional, Ruffilli, B., additional, Nardin, S., additional, Monti, M., additional, Puntoni, M., additional, Fontana, V., additional, Boni, L., additional, Harbeck, N., additional, Malagutti, Bianca, additional, Dib, Bassam, additional, Branni, Carmen, additional, D’Amico, Mauro, additional, Provinciali, Nicoletta, additional, Corradengo, Davide, additional, Fiz, Francesco, additional, Iacozzi, Massimiliano, additional, and Rocca, Andrea, additional

Published
2024
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28. The role of the deep convolutional neural network as an aid to interpreting brain [18F]DOPA PET/CT in the diagnosis of Parkinson’s disease

Author

Piccardo, Arnoldo, Cappuccio, Roberto, Bottoni, Gianluca, Cecchin, Diego, Mazzella, Luca, Cirone, Alessio, Righi, Sergio, Ugolini, Martina, Bianchi, Pietro, Bertolaccini, Pietro, Lorenzini, Elena, Massollo, Michela, Castaldi, Antonio, Fiz, Francesco, Strada, Laura, Cistaro, Angelina, and Del Sette, Massimo

Published
2021
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30. The Hough Transform and the Impact of Chronic Leukemia on the Compact Bone Tissue from CT-Images Analysis

Author

Massone, Anna Maria, Campi, Cristina, Fiz, Francesco, Beltrametti, Mauro Carlo, Patrizio, Giorgio, Editor-in-Chief, Canuto, Claudio, Series Editor, Coletti, Giulianella, Series Editor, Gentili, Graziano, Series Editor, Malchiodi, Andrea, Series Editor, Marcellini, Paolo, Series Editor, Mezzetti, Emilia, Series Editor, Moscariello, Gioconda, Series Editor, Ruggeri, Tommaso, Series Editor, Donatelli, Marco, editor, and Serra-Capizzano, Stefano, editor

Published
2019
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32. Reaching the target dose with one single 131I‐mIBG administration in high‐risk neuroblastoma: The determinant impact of the primary tumour

Author

Fiz, Francesco, primary, Cirone, Alessio, additional, Righi, Sergio, additional, Massollo, Michela, additional, Amoroso, Loredana, additional, Bottoni, Gianluca, additional, Conte, Massimo, additional, Gambaro, Monica, additional, Massone, Federico, additional, Orengo, Stefano, additional, Bruzzone, Guido Semino, additional, Sorrentino, Stefania, additional, Garaventa, Alberto, additional, and Piccardo, Arnoldo, additional

Published
2023
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33. The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy

Author

Piccardo, Arnoldo, primary, Treglia, Giorgio, additional, Fiz, Francesco, additional, Bar-Sever, Zvi, additional, Bottoni, Gianluca, additional, Biassoni, Lorenzo, additional, Borgwardt, Lise, additional, de Keizer, Bart, additional, Jehanno, Nina, additional, Lopci, Egesta, additional, Kurch, Lars, additional, Massollo, Michela, additional, Nadel, Helen, additional, Roca Bielsa, Isabel, additional, Shulkin, Barry, additional, Vali, Reza, additional, De Palma, Diego, additional, Cecchin, Diego, additional, Santos, Ana Isabel, additional, and Zucchetta, Pietro, additional

Published
2023
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38. Radiomic Analysis of Intrahepatic Cholangiocarcinoma: Non-Invasive Prediction of Pathology Data: A Multicenter Study to Develop a Clinical–Radiomic Model

Author

Fiz, Francesco, primary, Rossi, Noemi, additional, Langella, Serena, additional, Ruzzenente, Andrea, additional, Serenari, Matteo, additional, Ardito, Francesco, additional, Cucchetti, Alessandro, additional, Gallo, Teresa, additional, Zamboni, Giulia, additional, Mosconi, Cristina, additional, Boldrini, Luca, additional, Mirarchi, Mariateresa, additional, Cirillo, Stefano, additional, De Bellis, Mario, additional, Pecorella, Ilaria, additional, Russolillo, Nadia, additional, Borzi, Martina, additional, Vara, Giulio, additional, Mele, Caterina, additional, Ercolani, Giorgio, additional, Giuliante, Felice, additional, Ravaioli, Matteo, additional, Guglielmi, Alfredo, additional, Ferrero, Alessandro, additional, Sollini, Martina, additional, Chiti, Arturo, additional, Torzilli, Guido, additional, Ieva, Francesca, additional, and Viganò, Luca, additional

Published
2023
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41. Comparison of coronary flow reserve estimated by dynamic radionuclide SPECT and multi-detector x-ray CT

Author

Marini, Cecilia, Seitun, Sara, Zawaideh, Camilla, Bauckneht, Matteo, Morelli, Margherita Castiglione, Ameri, Pietro, Ferrarazzo, Giulia, Budaj, Irilda, Balbi, Manrico, Fiz, Francesco, Boccalini, Sara, Pregliasco, Athena Galletto, Buschiazzo, Ambra, Saracco, Alice, Bagnara, Maria Claudia, Bruzzi, Paolo, Brunelli, Claudio, Ferro, Carlo, Bezante, Gian Paolo, and Sambuceti, Gianmario

Published
2017
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42. Radioisotope-Guided Excision of Mediastinal Lymph Nodes in Patients with Non-Small Cell Lung Carcinoma: Feasibility and Clinical Impact

Author

Pini, Cristiano, primary, Bottoni, Edoardo, additional, Fiz, Francesco, additional, Giudici, Veronica Maria, additional, Alloisio, Marco, additional, Testori, Alberto, additional, Rodari, Marcello, additional, Sollini, Martina, additional, Chiti, Arturo, additional, Cariboni, Umberto, additional, and Antunovic, Lidija, additional

Published
2023
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43. PET Radiomics and Response to Immunotherapy in Lung Cancer: A Systematic Review of the Literature

Author

Evangelista, Laura, primary, Fiz, Francesco, additional, Laudicella, Riccardo, additional, Bianconi, Francesco, additional, Castello, Angelo, additional, Guglielmo, Priscilla, additional, Liberini, Virginia, additional, Manco, Luigi, additional, Frantellizzi, Viviana, additional, Giordano, Alessia, additional, Urso, Luca, additional, Panareo, Stefano, additional, Palumbo, Barbara, additional, and Filippi, Luca, additional

Published
2023
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44. Long-term prognostic factors for PRRT in neuroendocrine tumors

Author

Trautwein, Nils Florian, primary, Schwenck, Johannes, additional, Jacoby, Johann, additional, Reischl, Gerald, additional, Fiz, Francesco, additional, Zender, Lars, additional, Dittmann, Helmut, additional, Hinterleitner, Martina, additional, and la Fougère, Christian, additional

Published
2023
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47. Analysis of Complications in (Crico‐) Tracheal Resection Anastomosis in Adults: A Multicenter Study.

Author

Fiz, Ivana, Filauro, Marta, Sampieri, Claudio, Ioppi, Alessandro, Vallin, Alberto, Fiz, Francesco, Koelmel, Jan Costantin, Lancini, Davide, Piazza, Cesare, Sittel, Christian, and Peretti, Giorgio

Abstract

Objectives: The gold standard treatments for advanced laryngotracheal stenosis (LTS) are represented by partial crico‐tracheal (PCTRA) or tracheal resection and anastomosis (TRA). These procedures are potentially burdened by high postoperative complication rates. We investigated the impact of the most common stenosis and patient‐related characteristics on the onset of complications in a multicentric cohort. Methods: We retrospectively analyzed patients who underwent PCTRA or TRA for LTS of different etiologies in three referral centers. We tested the effectiveness of these procedures, the impact of complications on the outcomes, and identified factors causing postoperative complications. Results: A total of 267 patients were included in the study (130 females; mean age, 51.46 ± 17.64 years). The overall decannulation rate was 96.4%. Altogether, 102 (38.2%) patients presented at least one complication, whereas 12 (4.5%) had two or more. The only independent predictor of post‐surgical complications was the presence of systemic comorbidities (p = 0.043). Patients experiencing complications needed additional surgery more frequently (70.1% vs. 29.9%, p < 0.001), and had a longer duration of hospitalization (20 ± 10.9 vs. 11.3 ± 4.1 days, p < 0.001). Six of 102 (5.9%) patients with complications had restenosis, although this event did not occur among patients without complications. Conclusion: PCTRA and TRA have an excellent success rate even when performed for high‐grade LTS. However, a significant percentage of patients may experience complications associated with a longer duration of hospitalization or the need for additional surgeries. The presence of medical comorbidities was independently related to an increased risk of complications. Level of evidence: 4 Laryngoscope, 133:2910–2919, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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