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13 results on '"Fix, Daniel J."'

1. Mesonephric and mesonephric-like carcinomas of the female genital tract: molecular characterization including cases with mixed histology and matched metastases

Author

da Silva, Edaise M., Fix, Daniel J., Sebastiao, Ana Paula Martins, Selenica, Pier, Ferrando, Lorenzo, Kim, Sarah H., Stylianou, Anthe, Da Cruz Paula, Arnaud, Pareja, Fresia, Smith, Evan S., Zehir, Ahmet, Konner, Jason A., Cadoo, Karen, Reis-Filho, Jorge S., Abu-Rustum, Nadeem R., Mueller, Jennifer J., Weigelt, Britta, and Park, Kay J.

Published
2021
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2. Genetic and molecular subtype heterogeneity in newly diagnosed early- and advanced-stage endometrial cancer

Author

Da Cruz Paula, Arnaud, DeLair, Deborah F., Ferrando, Lorenzo, Fix, Daniel J., Soslow, Robert A., Park, Kay J., Chiang, Sarah, Reis-Filho, Jorge S., Zehir, Ahmet, Donoghue, Mark T.A., Wu, Michelle, Brown, David N., Murali, Rajmohan, Friedman, Claire F., Zamarin, Dmitriy, Makker, Vicky, Mueller, Jennifer J., Leitao, Mario M., Jr, Abu-Rustum, Nadeem R., Aghajanian, Carol, and Weigelt, Britta

Published
2021
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9. Wilms Tumor of the Ovary: Review of the Literature and Report of Two Cases

Author

Turashvili, Gulisa, Fix, Daniel J., Soslow, Robert A., and Park, Kay J.

Subjects
Adult, Ovarian Neoplasms, endocrine system diseases, Adolescent, Ovary, Teratoma, Infant, Middle Aged, Immunohistochemistry, Wilms Tumor, female genital diseases and pregnancy complications, Article, Kidney Neoplasms, Young Adult, Child, Preschool, Rhabdomyosarcoma, Humans, Female, Child
Abstract

Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only nine cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe two patients with ovarian Wilms tumor: a 36-year-old female (patient 1) and a 16-year-old female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. They were each found to have unilateral ovarian masses measuring greater than 15 cm in size which were removed by unilateral salpingo-oophorectomy. Microscopically, the tumors exhibited the typical triphasic histology of Wilms tumor. In addition, the tumor from patient 1 contained elements of mature cystic teratoma, while an extensive rhabdomyosarcomatous component was identified in patient 2. Both tumors were diffusely and strongly positive for WT1 with variable staining for other biomarkers. The cases were diagnostically challenging and referred to our center for an expert opinion. Teratoid Wilms tumor in patient 1 is the second reported case of ovarian Wilms tumor arising in association with teratoma. Recognition of primary ovarian Wilms tumor requires a high index of suspicion and exclusion of other entities based on tumor morphology and immunohistochemical studies.

Published
2018

13. Clinicopathologic Characteristics of Mesonephric Adenocarcinomas and Mesonephric-like Adenocarcinomas in the Gynecologic Tract

Author

Pors, Jennifer, Segura, Sheila, Chiu, Derek S., Almadani, Noorah, Ren, Hezhen, Fix, Daniel J., Howitt, Brooke E., Kolin, David, McCluggage, W. Glenn, Mirkovic, Jelena, Gilks, Blake, Park, Kay J., and Hoang, Lynn

Abstract

Mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA) are uncommon neoplasms of the gynecologic tract that have until recently been poorly understood. Although their morphologic, immunohistochemical, and molecular profiles have been recently defined, little is known about their clinical behavior. Small studies have demonstrated inconsistent findings and no large studies have examined the clinical behavior of these adenocarcinomas. In this multi-institutional study, representing the largest and most stringently defined cohort of cases to date, we examined the clinicopathologic features of 99 MAs and MLAs (30 MAs of the uterine cervix, 44 MLAs of the endometrium, and 25 MLAs of the ovary). Only tumors with characteristic mesonephric morphology and either immunohistochemical or molecular support were included. Our results demonstrate that the majority of mesonephric neoplasms presented at an advanced stage (II to IV) (15/25 [60%] MA of the cervix, 25/43 [58%] MLA of the endometrium, and 7/18 [39%] MLA of the ovary). The majority (46/89 [52%] overall, 12/24 [50%] MA of the cervix, 24/41 [59%] MLA of the endometrium, and 10/24 [42%] MLA of the ovary) developed recurrences, most commonly distant (9/12 [75%] MA of the cervix, 22/24 [92%] MLA of the endometrium, and 5/9 [56%] MLA of the ovary). The 5-year disease-specific survival was 74% (n=26) for MA of cervix, 72% (n=43) for MLA of endometrium, and 71% (n=23) for MLA of ovary. Our results confirm that mesonephric neoplasms are a clinically aggressive group of gynecologic carcinomas that typically present at an advanced stage, with a predilection for pulmonary recurrence.

Published
2024
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