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522 results on '"Fitzgibbon, J"'

1. Ergastula

Author

Fitzgibbon, J. C.

Published
2018

3. European standard clinical practice - Key issues for the medical care of individuals with familial leukemia

Author

Förster, A, Davenport, C, Duployez, N, Erlacher, M, Ferster, A, Fitzgibbon, J, Göhring, G, Hasle, H, Jongmans, M, Kolenova, A, Kronnie, G, Lammens, T, Mecucci, C, Mlynarski, W, Niemeyer, C, Sole, F, Szczepanski, T, Waanders, E, Biondi, A, Wlodarski, M, Schlegelberger, B, Ripperger, T, Förster, Alisa, Davenport, Claudia, Duployez, Nicolas, Erlacher, Miriam, Ferster, Alina, Fitzgibbon, Jude, Göhring, Gudrun, Hasle, Henrik, Jongmans, Marjolijn C, Kolenova, Alexandra, Kronnie, Geertruijte, Lammens, Tim, Mecucci, Cristina, Mlynarski, Wojciech, Niemeyer, Charlotte M, Sole, Francesc, Szczepanski, Tomasz, Waanders, Esmé, Biondi, Andrea, Wlodarski, Marcin, Schlegelberger, Brigitte, Ripperger, Tim, Förster, A, Davenport, C, Duployez, N, Erlacher, M, Ferster, A, Fitzgibbon, J, Göhring, G, Hasle, H, Jongmans, M, Kolenova, A, Kronnie, G, Lammens, T, Mecucci, C, Mlynarski, W, Niemeyer, C, Sole, F, Szczepanski, T, Waanders, E, Biondi, A, Wlodarski, M, Schlegelberger, B, Ripperger, T, Förster, Alisa, Davenport, Claudia, Duployez, Nicolas, Erlacher, Miriam, Ferster, Alina, Fitzgibbon, Jude, Göhring, Gudrun, Hasle, Henrik, Jongmans, Marjolijn C, Kolenova, Alexandra, Kronnie, Geertruijte, Lammens, Tim, Mecucci, Cristina, Mlynarski, Wojciech, Niemeyer, Charlotte M, Sole, Francesc, Szczepanski, Tomasz, Waanders, Esmé, Biondi, Andrea, Wlodarski, Marcin, Schlegelberger, Brigitte, and Ripperger, Tim

Abstract

Although hematologic malignancies (HM) are no longer considered exclusively sporadic, additional awareness of familial cases has yet to be created. Individuals carrying a (likely) pathogenic germline variant (e.g., in ETV6, GATA2, SAMD9, SAMD9L, or RUNX1) are at an increased risk for developing HM. Given the clinical and psychological impact associated with the diagnosis of a genetic predisposition to HM, it is of utmost importance to provide high-quality, standardized patient care. To address these issues and harmonize care across Europe, the Familial Leukemia Subnetwork within the ERN PaedCan has been assigned to draft an European Standard Clinical Practice (ESCP) document reflecting current best practices for pediatric patients and (healthy) relatives with (suspected) familial leukemia. The group was supported by members of the German network for rare diseases MyPred, of the Host Genome Working Group of SIOPE, and of the COST action LEGEND. The ESCP on familial leukemia is proposed by an interdisciplinary team of experts including hematologists, oncologists, and human geneticists. It is intended to provide general recommendations in areas where disease-specific recommendations do not yet exist. Here, we describe key issues for the medical care of familial leukemia that shall pave the way for a future consensus guideline: (i) identification of individuals with or suggestive of familial leukemia, (ii) genetic analysis and variant interpretation, (iii) genetic counseling and patient education, and (iv) surveillance and (psychological) support. To address the question on how to proceed with individuals suggestive of or at risk of familial leukemia, we developed an algorithm covering four different, partially linked clinical scenarios, and additionally a decision tree to guide clinicians in their considerations regarding familial leukemia in minors with HM. Our recommendations cover, not only patients but also relatives that both should have access to adequate medical

Published
2023

4. Biallelic TET2 mutations confer sensitivity to 5 '-azacitidine in acute myeloid leukemia

Author

Stölzel, F. (Friedrich), Fordham, S.E. (Sarah E.), Nandana, D. (Devi), Lin, W.Y. (Wei-Yu), Blair, H. (Helen), Elstob, C. (Claire), Bell, H.L. (Hayden L.), Mohr, B. (Brigitte), Ruhnke, L. (Leo), Kunadt, D. (Desiree), Dill, C. (Claudia), Allsop, D. (Daniel), Piddock, R. (Rachel), Soura, E.N. (Emmanouela-Niki), Park, C. (Catherine), Fadly, M. (Mohd), Rahman, T. (Thahira), Alharbi, A. (Abrar), Wobus, M. (Manja), Altmann, H. (Heidi), Röllig, C. (Christoph), Wagenführ, L. (Lisa), Jones, G.L. (Gail L.), Menne, T. (Tobias), Jackson, G.H. (Graham H.), Marr, H.J. (Helen J.), Fitzgibbon, J. (Jude), Onel, K. (Kenan), Meggendorfer, M. (Manja), Robinson, A. (Amber), Bziuk, Z. (Zuzanna), Bowes, E. (Emily), Heidenreich, O. (Olaf), Haferlach, T. (Torsten), Villar-Fernández, S. (Sara), Ariceta, B. (Beñat), Ayala, R. (Rosa), Altschuler, S.J. (Steven J.), Wu, L.F. (Lani F.), Prosper, F. (Felipe), Montesinos, P. (Pau), Martínez-López, J. (Joaquín), Bornhauser, M. (Martin), and Allan, J.M. (James M.)

Abstract

Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5 '-azacitidine (5 '-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5 '-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5 '-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer.

Published
2023

5. The role of the public in developing interventions: a reflection and critique of a cancer clinical trials unit’s model

Author

Fitzgibbon J, Baillie J, Simon N, and Nelson A

Subjects
Medicine (General), R5-920
Abstract

Jim Fitzgibbon,1 Jessica Baillie,1 Natalie Simon,2 Annmarie Nelson11Marie Curie Palliative Care Research Centre, School of Medicine, Cardiff University, Cardiff, Wales; 2Involving People, National Institute for Social Care and Health Research Clinical Research Centre, Cardiff, WalesAbstract: The importance of involving lay representatives in research is well-recognized but is not consistently meaningfully practiced or reported. Although the positive outcomes of lay representative involvement can include more relevant research questions and outcomes, challenges are also apparent, including tokenistic involvement by research teams. A Cancer Research UK-funded and National Cancer Research Institute-registered cancer clinical trials unit in the United Kingdom established a program of work to promote genuine and consistent involvement of lay representatives (or “research partners”) as part of the research team. Furthermore, a volunteer was employed to recruit and coordinate the research partners in partnership with a national agency for public involvement in health and social care research in Wales. This article reports on the development of this project and how it will be formally evaluated. Recommendations for involving lay representatives are also posed.Keywords: public involvement, lay representative, clinical trials unit

Published
2014

6. P405: INHIBITION OF CKS1-DEPENDENT PROTEOSTASIS REVEALS VULNERABILITIES IN LEUKAEMIC STEM CELLS WITH CONCOMITANT PROTECTION OF HEALTHY HAEMATOPOIETIC STEM CELLS

Author

Grey, W., primary, Rio-Machin, A., additional, Casado-Izquierdo, P., additional, Gronroos, E., additional, Ali, S., additional, Miettinen, J., additional, Bewicke-Copley, F., additional, Parsons, A., additional, Heckman, C., additional, Swanton, C., additional, Cutillas, P., additional, Gribben, J., additional, Fitzgibbon, J., additional, and Bonnet, D., additional

Published
2022
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11. The Model Cities Project of the Department of Education in New Jersey. Report of a Study.

Author

Improving State Leadership in Education, Denver, CO., New Jersey State Dept. of Education, Trenton., and Fitzgibbon, J. Gerald

Abstract

This report provides a case study of cooperation between the New Jersey Department of Education and the Model Cities Program to improve State education planning and to restructure grant administration machinery. To assist the project, the Department provided onsite technical assistance to the model cities. According to the report, the Department fulfilled its technical assistance mission by assigning its personnel full time to local communities. Concurrent with its field activities, the Model Cities Project provided back-up support to the Department and engaged in planning to secure additional resources for Model Cities. The project also assisted the Department in planning for the administration of federal funds. (JF)

Published
1971

14. EZH2 Y641 mutations in follicular lymphoma

Author

Bödör, C, O'Riain, C, Wrench, D, Matthews, J, Iyengar, S, Tayyib, H, Calaminici, M, Clear, A, Iqbal, S, Quentmeier, H, Drexler, H G, Montoto, S, Lister, A T, Gribben, J G, Matolcsy, A, and Fitzgibbon, J

Published
2011
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15. Array-based DNA methylation profiling in follicular lymphoma

Author

O'Riain, C, O'Shea, D M, Yang, Y, Le Dieu, R, Gribben, J G, Summers, K, Yeboah-Afari, J, Bhaw-Rosun, L, Fleischmann, C, Mein, C A, Crook, T, Smith, P, Kelly, G, Rosenwald, A, Ott, G, Campo, E, Rimsza, L M, Smeland, E B, Chan, W C, Johnson, N, Gascoyne, R D, Reimer, S, Braziel, R M, Wright, G W, Staudt, L M, Lister, T A, and Fitzgibbon, J

Published
2009
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17. Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

Author

Barbosa, RR, Xu, AQ, D’Andrea, D, Copley, F, Patel, H, Chakravarty, P, Clear, A, Calaminici, M, Janz, M, Zhang, B, Schmidt-Supprian, M, Wang, J, Gribben, JG, Tooze, R, Fitzgibbon, J, Franzoso, G, Rajewsky, K, Calado, DP, Medical Research Council (MRC), Cancer Research UK, Bloodwise, and Imperial College Healthcare NHS Trust- BRC Funding

Abstract

NF-κB and MYC are found co-deregulated in human B and plasma-cell cancers. In physiology, NF-κB is necessary for terminal B-to-plasma cell differentiation, whereas MYC repression is required. It is thus unclear if NF-κB/MYC co-deregulation is developmentally compatible in carcinogenesis and/or impacts cancer cell differentiation state, possibly uncovering unique sensitivities. Using a mouse system to trace cell lineage and oncogene activation we found that NF-κB/MYC co-deregulation originated cancers with a plasmablast-like phenotype, alike human plasmablastic-lymphoma and was linked to t(8;14)[MYC-IGH] multiple myeloma. Notably, in contrast to NF-κB or MYC activation alone, co-deregulation rendered cells addicted to IL6 for survival and phenotypic stability. We propose that conflicting oncogene-driven differentiation pressures can be accommodated at a cost in poorly-differentiated cancers.

Published
2020

18. Recent Advancements in Hematology: Knowledge, Methods and Dissemination

Author

Fitzgibbon, J, Busca, A, Gloghini, A, Lopez-Guillermo, A, Orazi, A, Carlo-Stella, C, Andres, E, Van Breda, E, Busti, F, Garderet, L, Martini, M, Dolcetti, R, De Rosa, S, Siragusa, S, Marafioti, T, Carbone, A, Fitzgibbon, J, Busca, A, Gloghini, A, Lopez-Guillermo, A, Orazi, A, Carlo-Stella, C, Andres, E, Van Breda, E, Busti, F, Garderet, L, Martini, M, Dolcetti, R, De Rosa, S, Siragusa, S, Marafioti, T, and Carbone, A

Abstract

Communication in the field of biomedical research today involves professionals of numerous backgrounds, including researchers, doctors, public administrators, politicians, and health journalists [...]

Published
2020

19. Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 1

Author

Fitzgibbon, J, Park, S, Cook, G, Paiva, B, Gloghini, A, Van Breda, E, Busti, F, Garderet, L, Dolcetti, R, Robin, M, Martino, R, Busca, A, Sabbah, M, De Rosa, S, Martini, M, Onida, F, Aucouturier, P, Schjesvold, F, Minvielle, S, Mazzucato, M, Terragna, C, Delforge, M, Harrison, C, Carbone, A, Fitzgibbon, J, Park, S, Cook, G, Paiva, B, Gloghini, A, Van Breda, E, Busti, F, Garderet, L, Dolcetti, R, Robin, M, Martino, R, Busca, A, Sabbah, M, De Rosa, S, Martini, M, Onida, F, Aucouturier, P, Schjesvold, F, Minvielle, S, Mazzucato, M, Terragna, C, Delforge, M, Harrison, C, and Carbone, A

Abstract

Recent Advancements in Hematology: Knowledge, Methods and Dissemination is a series of editorials which is published on a biannual basis by the editorial board of the journal Bloods [...]

Published
2020

24. Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. (Inflammatory Bowel Disease)

Author

McCarthy, J., O'Mahony, L., O'Callaghan, L., Sheil, B., Vaughan, E.E., Fitzsimons, N., Fitzgibbon, J., O'Sullivan, G.C., Kiely, B., Collins, J.K., and Shanahan, F.

Subjects
Cytokines -- Physiological aspects -- Usage -- Health aspects, Genetically modified mice -- Usage -- Health aspects -- Physiological aspects, Colitis -- Physiological aspects -- Prevention, Probiotics -- Health aspects -- Usage -- Physiological aspects, Health, Prevention, Physiological aspects, Usage, Health aspects
Abstract

Background: Prophylactic efficacy against colitis following lactobacillus consumption in interleukin 10 (IL-10) knockout (KO) mice has been reported. Whether this applies equally to other probiotic strains is unknown, and the [...]

Published
2003

26. Human herpesvirus 8 (HHV-8) detected in two patients with Kaposi's sarcoma-like pyogenic granuloma. (Case Report)

Author

Ryan, P., Aarons, S., Murray, D., Markham, T., O'Sullivan, S., Lyons, F., Lee, G., and Fitzgibbon, J.

Subjects
Human herpesvirus 8 -- Health aspects, Granuloma -- Risk factors, Health, Risk factors, Health aspects
Abstract

Aims: To report the finding of human herpesvirus 8 (HHV-8) in two patients with Kaposi's sarcoma (KS)-like pyogenic granuloma. This form of pyogenic granuloma closely resembles KS histologically and it [...]

Published
2002

31. Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability

Author

Barbosa, RR, primary, Xu, AQ, additional, D’Andrea, D, additional, Copley, F, additional, Patel, H, additional, Chakravarty, P, additional, Clear, A, additional, Calaminici, M, additional, Janz, M, additional, Zhang, B, additional, Schmidt-Supprian, M, additional, Wang, J, additional, Gribben, JG, additional, Tooze, R, additional, Fitzgibbon, J, additional, Franzoso, G, additional, Rajewsky, K, additional, and Calado, DP, additional

Published
2020
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34. Array-based DNA methylation profiling in follicular lymphoma

Author

OʼRiain, C, OʼShea, D M, Yang, Y, Le Dieu, R, Gribben, J G, Summers, K, Yeboah-Afari, J, Bhaw-Rosun, L, Fleischmann, C, Mein, C A, Crook, T, Smith, P, Kelly, G, Rosenwald, A, Ott, G, Campo, E, Rimsza, L M, Smeland, E B, Chan, W C, Johnson, N, Gascoyne, R D, Reimer, S, Braziel, R M, Wright, G W, Staudt, L M, Lister, T A, and Fitzgibbon, J

Published
2009

37. Water Vapor Measurements by Howard University Raman Lidar during the WAVES 2006 Campaign

Author

Adam, M, Demoz, B. B, Whiteman, D. N, Venable, D. D, Joseph E, Gambacorta, A, Wei, J, Shephard, M. W, Miloshevich, L. M, Barnet, C. D, Herman, R. L, Fitzgibbon, J, and Connell, R

Subjects
Oceanography
Abstract

Retrieval of water vapor mixing ratio using the Howard University Raman Lidar is presented with emphasis on three aspects: i) performance of the lidar against collocated radiosondes and Raman lidar, ii) investigation of the atmospheric state variables when poor agreement between lidar and radiosondes values occurred and iii) a comparison with satellite-based measurements. The measurements were acquired during the Water Vapor Validation Experiment Sondes/Satellites 2006 field campaign. Ensemble averaging of water vapor mixing ratio data from ten night-time comparisons with Vaisala RS92 radiosondes shows on average an agreement within 10 % up to approx. 8 km. A similar analysis of lidar-to-lidar data of over 700 profiles revealed an agreement to within 20 % over the first 7 km (10 % below 4 km). A grid analysis, defined in the temperature - relative humidity space, was developed to characterize the lidar - radiosonde agreement and quantitatively localizes regions of strong and weak correlations as a function of altitude, temperature or relative humidity. Three main regions of weak correlation emerge: i) regions of low relative humidity and low temperature, ii) moderate relative humidity at low temperatures and iii) low relative humidity at moderate temperatures. Comparison of Atmospheric InfraRed Sounder and Tropospheric Emission Sounder satellites retrievals of moisture with that of Howard University Raman Lidar showed a general agreement in the trend but the formers miss a lot of the details in atmospheric structure due to their low resolution. A relative difference of about 20 % is usually found between lidar and satellites measurements.

Published
2009

40. The Water Vapor Variability - Satellite/Sondes (WAVES) Field Campaigns

Author

Whiteman, D. N, Adam, M, Barnet, C, Bojkov, B, Delgado, R, Demoz, B, Fitzgibbon, J, Forno, R, Herman, R, Hoff, E, Joseph, E, Landulfo, E, McCann, K, McGee, T, Miloshevich, L, Restrepo, I, Schmidlin, F. J, Taubman, B, Thompson, A, Twigg, L, Venable, D, Vomel, H, and Walthall, C

Subjects
Earth Resources And Remote Sensing
Abstract

Three NASA-funded field campaigns have been hosted at the Howard University Research Campus in Beltsville, MD. In each of the years 2006, 2007 and 2008, WAVES field campaigns have coordinated ozonesonde launches, lidar operations and other measurements with A-train satellite overpasses for the purposes of satellite validation. The unique mix of measurement systems, physical location and the interagency, international group of researchers and students has permitted other objectives, such as mesoscale meteorological studies, to be addressed as well. We review the goals and accomplishments of the three WAVES missions with the emphasis on the nonsatellite validation component of WAVES, as the satellite validation activities have been reported elsewhere.

Published
2008

49. Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia

Author

Cardoso, S R, Ryan, G, Walne, A J, Ellison, A, Lowe, R, Tummala, H, Rio-Machin, A, Collopy, L, Al Seraihi, A, Wallis, Y, Page, P, Akiki, S, Fitzgibbon, J, Vulliamy, T, and Dokal, I

Subjects
Adult, Male, Heterozygote, Middle Aged, Pedigree, DEAD-box RNA Helicases, Leukemia, Myeloid, Acute, Germ Cells, Myelodysplastic Syndromes, Mutation, Humans, Female, Letter to the Editor, Aged
Published
2016

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