45 results on '"Fitzgerald, I."'
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2. Overview of recent physics results from MAST
- Author
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Kirk, A, Adamek, J, Akers, RJ, Allan, S, Appel, L, Lucini, F Arese, Barnes, M, Barrett, T, Ayed, N Ben, Boeglin, W, Bradley, J, Browning, P K, Brunner, J, Cahyna, P, Carr, M, Casson, F, Cecconello, M, Challis, C, Chapman, IT, Chapman, S, Conroy, S, Conway, N, Cooper, WA, Cox, M, Crocker, N, Crowley, B, Cardnell, S, Chorley, J, Cunningham, G, Danilov, A, Darrow, D, Dendy, R, Dickinson, D, Dorland, W, Dudson, B, Easy, L, Elmore, S, Evans, M, Farley, T, Fedorczak, N, Field, A, Fitzgerald, I, Fox, M, Freethy, S, Garzotti, L, Ghim, YC, Gi, K, Gorelenkova, M, Gracias, W, Gurl, C, Guttenfelder, W, Ham, C, Harting, D, Havlickova, E, Hawkes, N, Hender, T, Henderson, S, Hillesheim, J, Hnat, B, Horacek, J, Howard, J, Howell, D, Dunai, D, Fishpool, G, Gibson, K, Harrison, J, Highcock, E, Huang, B, Inomoto, M, Imazawa, R, Jones, O, Kadowaki, K, Kaye, S, Keeling, D, Kocan, M, Kogan, L, Komm, M, Lai, W, Leddy, J, Leggate, H, Imada, K, Klimek, I, Hollocombe, J, Lipschultz, B, Lisgo, S, Liu, YQ, Lloyd, B, Lomanowski, B, Lukin, V, Maddison, G, Madsen, J, Mailloux, J, Martin, R, McArdle, G, Lupelli, I, McClements, K, McMillan, B, Meakins, A, Meyer, H, Michael, C, Militello, F, Milnes, J, Motojima, G, Muir, D, Naylor, G, Nielsen, A, O'Brien, M, O'Mullane, M, Olsen, J, Omotani, J, Ono, Y, Pamela, S, Morris, AW, O'Gorman, T, Pangione, L, Parra, F, Patel, A, Peebles, W, Perez, R, Pinches, S, Piron, L, Price, M, Reinke, M, Ricci, P, Riva, F, Roach, C, Romanelli, M, Ryan, D, Saarelma, S, Saveliev, A, Scannell, R, Schekochihin, A, Sharapov, S, Sharples, R, Shevchenko, V, Shinohara, K, Silburn, S, Simpson, J, Stanier, A, Storrs, J, Summers, H, Takase, Y, Tamain, P, Tanabe, H, Tanaka, H, Tani, K, Taylor, D, Thomas, D, Thomas-Davies, N, Thornton, A, Turnyanskiy, M, Valovic, M, Vann, R, Van Wyk, F, Walkden, N, Watanabe, T, Wilson, H, Wischmeier, M, Yamada, T, Young, J, Zoletnik, S, Team, the MAST, and Team, the EUROfusion MST1
- Subjects
Physics - Plasma Physics - Abstract
New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp up models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge detailed studies have revealed how filament characteristic are responsible for determining the near and far SOL density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during ELMs and the number of filaments released determines the power profile at the divertor. Resonant magnetic perturbations can mitigate ELMs provided the edge peeling response is maximised and the core kink response minimised. The mitigation of intrinsic error fields with toroidal mode number n>1 has been shown to be important for plasma performance., Comment: 34 pages, 10 figures. This is an author-created, un-copyedited version of an article submitted for publication in Nuclear Fusion. IoP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it
- Published
- 2016
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3. Electron and ion heating characteristics during magnetic reconnection in MAST
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Tanabe, H., Yamada, T., Watanabe, T., Gi, K., Kadowaki, K., Inomoto, M., Imazawa, R., Gryaznevich, M., Michael, C., Crowley, B., Conway, N., Scannell, R., Harrison, J., Fitzgerald, I., Meakins, A., Hawkes, N., team, the MAST, Cheng, C. Z., and Ono, Y.
- Subjects
Physics - Plasma Physics - Abstract
Local electron and ion heating characteristics during merging reconnection startup on the MAST spherical tokamak have been revealed for the first time using a 130 channel YAG-TS system and a new 32 chord ion Doppler tomography diagnostic. 2D local profile measurement of $T_e$, $n_e$ and $T_i$ detect highly localized electron heating at the X point and bulk ion heating downstream. For the push merging experiment under high guide field condition, thick layer of closed flux surface formed by reconnected field sustains the heating profile for more than electron and ion energy relaxation time $\tau^E_{ei}\sim4-10$ms, both heating profiles finally form triple peak structure at the X point and downstream. Toroidal guide field mostly contributes the formation of peaked electron heating profile at the X point. The localized heating increases with higher guide field, while bulk downstream ion heating is unaffected by the change in the guide field under MAST conditions ($B_t>3B_{rec}$)., Comment: The article has been submitted to the journal of "Physical Review Letters" on 05/May/2015 (Code number: LE15049 (5 pages, 5 figures))
- Published
- 2015
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4. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, Miller, F, Chouari, T, Gardner, T, Goergen, N, Hayes, J, Macleod, C, Mccormack, R, Mckinley, A, Mckinstry, S, Milligan, W, Ooi, L, Rafiq, N, Sammut, T, Sinclair, E, Smith, M, Wong, J, Ablett, A, Tie-Gill, T, Ramsay, G, De Paola, L, Mcguckin, S, Alshakhs, A, Ahmeidat, A, Francis, A, Baker, C, Boulton, A, Collins, J, Copley, H, Fearnhead, N, Fox, H, Mah, T, Mckenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, Yang, D, Ali, Z, Mullarkey, L, Walshe, R, Lewis, E, Berry, B, Moneim, J, Mookerjee, S, Al-Hadithi, A, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Gascon Perai, K, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, Mccartan, N, Ormrod, A, Pakenham, A, Christy, S, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, Vivian, F, Ali, B, Cresswell, B, Dhillon, A, Dupaguntla, Y, Hungwe, C, Lowe-Zinola, J, Tsang, J, Wcislo, K, Bevan, K, Cardus, C, Duggal, A, Hossain, S, Mchugh, M, Scott, M, Millar, Z, Hirosue, S, Ogunmwonyi, I, Nakakande, D, Chan, F, Evans, R, Gurung, E, Haughey, B, Jacob-Ramsdale, B, Kerr, M, Lee, J, Mccann, E, O'Boyle, K, Reid, N, Kwek, I, Gaze, H, Nirmalanantha, A, Bin Amran, M, Foulkes, A, Jones, N, Lau, I, Hayat, F, Hodgson, S, Johnston, R, Jones, W, Khan, M, Linn, T, Long, S, Seetharam, P, Shaman, S, Smart, B, Pillai, S, Khoury, G, Powell, T, Maleyko, I, Sangheli, A, Ransome, M, Isse, M, Aromolaran, O, Bholah, H, Anilkumar, A, Davies, J, Griffith, J, Hughes, B, Islam, Y, Kidanu, D, Mushaini, N, Qamar, I, Robinson, H, Schramm, M, Yan Tan, C, Murray, V, Theocharidou, L, Malik, T, Janmohamed, I, Carhart, B, Khan, A, Apperley, H, Billyard, C, Blazeby, J, Cannon, S, Carse, S, Gopfert, A, Loizidou, A, Parkin, J, Sanders, E, Sharma, S, Slade, G, Telfer, R, Whybrow Huppatz, I, Worley, E, Asif, A, Hullait, R, Quinn, P, Rylance, A, Butt, S, Leathes, J, Chandramoorthy, L, Friend, C, Harris, L, Jain, P, Karim, M, Killington, K, Mcgillicuddy, J, Rafferty, C, Rahunathan, N, Rayne, T, Varathan, Y, Verma, N, Zanichelli, D, Arneill, M, Campbell, B, Crozier, L, Henry, J, Mccusker, C, Prabakaran, P, Wilson, R, Karelia, S, Clements, J, Rainey, M, Asif, U, Connor, M, Dindyal, S, Math, N, Pagarkar, A, Saleem, H, Seth, I, Standfield, N, Swartbol, T, Adamson, R, Choi, J, El Tokhy, O, Ho, W, Javaid, N, Mehdi, A, Menon, D, Plumptre, I, Sturrock, S, Turner, J, Warren, O, Joshi, N, Rahman, A, Gallagher, M, Crane, E, Ferris, B, Gadsby, C, Smallwood, J, Vipond, M, Wilson, V, Amarnath, T, Doshi, A, Gregory, C, Kandiah, K, Powell, B, Spoor, H, Toh, C, Vizor, R, Rebuffa, N, Abdelgalil, R, Siaw Yen Lai, R, Smith, E, Common, M, Dunleavy, K, Harris, S, Luo, C, Mesbah, Z, Prem Kumar, A, Redmond, A, Skulsky, S, Walsh, T, Daly, D, Deery, L, Epanomeritakis, E, Harty, M, Kane, D, Khan, K, Mackey, R, Mcconville, J, Mcginnity, K, Wong, H, Ang, A, Kee, J, Leung, E, Norman, S, Palaniappan, S, Partha Sarathy, P, Yeoh, T, Frost, J, Hazeldine, P, Jones, L, Karbowiak, M, Macdonald, C, Mutarambirwa, A, Omotade, A, Runkel, M, Ryan, G, Sawers, N, Searle, C, Vig, S, Hlukha, L, Pike, G, Kamel, F, Thakkar, R, Mcauliffe, O, Ahmad, A, Mcgartland, R, Sim, R, Song, A, Wayman, J, Brown, R, Chang, L, Concannon, K, Crilly, C, Arnold, T, Burgin, A, Cadden, F, Choy, C, Coleman, M, Lim, D, Luk, J, Mahankali-Rao, P, Prudence-Taylor, A, Ramakrishnan, D, Russell, J, Fawole, A, Gohil, J, Green, B, Hussain, A, Mcmenamin, L, Tang, M, Azmi, F, Benchetrit, S, Cope, T, Haque, A, Harlinska, A, Holdsworth, R, Ivo, T, Martin, J, Nisar, T, Patel, A, Sasapu, K, Trevett, J, Vernet, G, Aamir, A, Bird, C, Durham-Hall, A, Gibson, W, Hartley, J, May, N, Maynard, V, Goble, M, Downs, E, Wheldon, L, Baggus, E, Mandal, A, Nayeem, A, Ahmed, S, Fradley, W, Johnson, S, McDonald Wood, C, O'Brien, M, Orbell, J, Stringfellow, T, Tenters, F, Tresidder, S, Wilson, C, Gallagher, S, Criswell, T, Ward, J, Mukkavilli, A, Stubbs, B, Fordyce, W, Cheung, W, Grant, A, Tod, N, Yi Tew, Z, Suchdev, N, Wei Lim, S, Bews-Hair, M, Lim, Z, Vella-Baldacchino, M, Auckburally, S, Chopada, A, Easdon, S, Goodson, R, Mccurdie, F, Narouz, M, Radford, A, Rea, E, Taylor, O, Yu, T, Sookramanien, S, Chan, A, Bointas, G, Alfa-Wali, M, Amani, L, Auluck, I, Bruce, P, Emberton, J, Kumar, R, Lagzouli, N, Mehta, A, Murtaza, A, Raja, M, Dennahy, I, Frew, K, Given, A, He, Y, Macdonald, E, Mcvinnie, D, Ng, S, Pettit, A, Berthaume-Hawkins, S, Charnley, R, Fenton, K, Jones, D, Murphy, C, Reehal, R, Seraj, S, Shang, E, Tonks, A, White, P, Yeo, A, Paul, M, Ward, K, Bagnall, M, Chong, P, Gabriel, R, Patel, N, Richardson, E, Symons, L, Aubrey-Jones, D, Dawood, S, Dobrzynska, M, Faulkner, S, Griffiths, H, Mahmood, F, Perry, M, Power, A, Simpson, R, Pherwani, S, Wang, K, Mitchell, L, Heyworth, J, Ayyar, S, Brobbey, P, Burrows, A, Elder, P, Ganyani, R, Horseman, C, Hurst, P, Mann, H, Marimuthu, K, Mcbride, S, Pilsworth, E, Powers, N, Stanier, P, Obukofe, R, Polson, R, Mason, D, Mackenzie, E, Innes, R, Kersey, T, Kopczynska, M, Langasco, N, Rajagopal, R, Russell, C, Doyle, N, Habib, Z, Zardab, M, Sartaj, F, Farooq, H, Tabibi, M, Imam, L, Atkins, B, Beasley, W, Cheng Lim, Z, Gill, A, Li Ang, H, Williams, H, Yogeswara, T, Drury, D, James, S, Barnett, R, Teasdale, A, Thomas, D, Williams, R, Najabat-Lattif, H, Akram, B, Carter, R, Fam, M, Fong, J, Latter, J, Long, M, Mackinnon, S, Mckenzie, C, Osmanska, J, Raghuvir, V, Shafi, A, Tsang, K, Walker, L, Cahya, E, Lou, G, Coyle, M, Homyer, K, Zhu, L, Woods, M, Bountra, K, Coldicutt, O, Fletcher, D, Hudson, S, Iqbal, S, Lopez Bernal, T, Moss-Lawton, F, Suchett-Kay, I, Chang, J, O'Callaghan, H, Suchett-Kaye, I, Mihailidis, T, Cardwell, A, Edgerton, K, Laws, J, Rai, A, Robinson, K, Waite, K, Youssef, H, Alawattegama, H, Seite, E, Barrett, A, Riordan, E, Lam, W, Dowdeswell, M, Mulvenna, C, Knight, C, Koo, P, Lazarou, A, Stanger, S, Thorn, C, Triniman, M, Netke, T, Awokoya, O, Gurowich, L, Dhera, K, Hossaini, S, Botha, A, Boyles, L, Cumming, S, Deepak, S, Ezzat, A, Fowler, A, Gwozdz, A, Hussain, S, Khan, S, Li, H, Lu Morrell, B, Neville, J, Nitiahpapand, R, Pickering, O, Sagoo, H, Sharma, E, Welsh, K, Williams, L, Hayat, S, Tincknell, L, Spazzapan, M, Teeling, F, Sysum, K, Denley, S, Latter, M, Agarwal, M, Al-Saadi, N, Bhambra, R, Gupta, A, Jawad, Z, Jiao, L, Mahir, G, Singagireson, S, Thoms, B, Tseu, B, Wei, R, Yang, N, Britton, N, Leinhardt, D, Mahfooz, M, Palkhi, A, Price, M, Sheikh, S, Barker, M, Bowley, D, Cant, M, Datta, U, Farooqi, M, Lee, A, Morley, G, Naushad Amin, M, Parry, A, Patel, S, Strang, S, Yoganayagam, N, Guruswamy, M, Beedham, W, Brazier, E, Elghobashy, M, Bajaj, M, Etel, E, Adlan, A, Chandramoorthy, S, Choudhary, Y, Das, K, Feldman, M, France, B, Grace, R, Puddy, H, Soor, P, Kisiel, A, Woodmass, M, Hayden, H, Ali, Y, Husain, S, Ali, M, Dhillon, P, Faraj, A, Gerard, L, Glover, M, Imran, H, Kim, S, Patrick, Y, Peto, J, Prabhudesai, A, Tang, A, Vadgama, N, Dhaliwal, R, Ecclestone, T, Harris, A, Ong, D, Patel, D, Philp, C, Stewart, E, Wang, L, Wong, E, Xu, Y, Ashaye, T, Fozard, T, Galloway, F, Kaptanis, S, Mistry, P, Nguyen, T, Olagbaiye, F, Osman, M, Philip, Z, Rembacken, R, Tayeh, S, Theodoropoulou, K, Liu, F, Arnold, A, Pedersen, A, Cunha, P, Ahmed, M, Al Zawawi, S, Kudva, V, Herman, A, Lau, J, Saha, A, Trotter, M, Miscampbell, M, Robinson, A, Johnston, J, Dharni, A, Lamb, S, Westerman, T, Adeleye, O, Cave, D, Gunwa, T, Magalhaes, J, Makwana, S, Mason, R, Parish, M, Regan, H, Renwick, P, Roberts, G, Salekin, D, Sivakumar, C, Tariq, A, Liew, I, Mcdade, A, Stewart, D, Evans, E, Campbell, L, Gillespie, M, Cheong, C, Hague, M, Hudson-Peacock, N, Jackson, C, James, F, Pitt, J, Walker, E, Kulathevanayagam, K, Varghese, A, Ike, S, Aftab, R, Ang, J, Anwar, S, Battle, J, Budd, E, Chui, J, Crook, H, Davies, P, Easby, S, Hackney, E, Ho, B, Imam, S, Rammell, J, Chu, T, Baljer, B, Mogg, J, Rai, P, Andrews, H, Perry, C, Schinle, P, Ahmed, P, Aquilina, T, Balai, E, Church, M, Cumber, E, Curtis, A, Davies, G, Dumann, E, Greenhalgh, S, Kim, P, King, S, Metcalfe, K, Passby, L, Redgrave, N, Soonawalla, Z, Waters, S, Zornoza, A, Williams, M, Smillie, R, Goetz, J, Appleby, E, Fadipe, T, Vaughan-Burleigh, S, Davies, R, Gulzar, I, Hole, J, Hull, K, Ishaq, H, Karaj, J, Kelkar, A, Love, E, Thakrar, D, Vine, M, Waterman, A, James, P, Puri, G, Hussain, P, Flather, R, Cutler, A, Pathak, S, Sheldon, J, Collicott, T, al-Ausi, M, Ko, M, Dib, N, Francis, N, Hanson, M, Ingleton, R, Sadanand, K, Sukirthan, N, Mondal, A, Jovaisaite, A, Shah, S, Khalid, N, Gutmann, D, Davison, S, Alame, Y, Syed, L, Owen, W, Arnell, S, Ball, M, Bassam, N, Beghal, G, Chang, A, Dawe, V, George, A, Huq, T, Ikram, B, Kanapeckaite, L, Ramjas, D, Rushd, A, Sait, S, Serry, M, Yardimci, E, Kalderon, R, Ahsan, S, Anthony-Uzoeto, U, Macleod Hall, C, Zheng, S, Wynter, K, Capella, S, Chenciner, L, Episkopos, C, Karam, E, Mccarthy, C, Moore-Kelly, W, Watson, N, Nadama, H, James, C, Sapre, D, Ghosh, R, Baird, J, Cockburn, L, Blackwood, O, Simpson, W, Ahluwalia, V, Barnfield, J, Ben-Gal, O, Bloom, I, Gharatya, A, Khodatars, K, Merchant, N, Moonan, A, Moore, M, Patel, K, Spiers, H, Sundaram, K, Jeong, S, Bishop, S, Black, J, Chadwick, H, Huisman, L, Ingram, H, Martin, L, Metcalfe, M, Sangal, P, Seehra, J, Thatcher, A, Venturini, S, Whitcroft, I, Bate, R, Hobson, C, Adam, A, Redclift, C, Do, J, Poli, F, Batterham, A, Brown, S, Pandya, A, Afzal, Z, Gani, A, Gomaa, A, Hussein, N, Oh, S, Pazhaniappan, N, Sharkey, E, Sivagnanasithiyar, T, Williams, C, Yeung, J, Parekh, J, Clay, W, Pieri, K, Jackson, A, Saxena, A, Gurung, B, Oyebola, T, O'Brien, F, Reilly, S, Cruddas, L, Gurjar, S, Pau, A, Prakash, R, Randhawa, R, Djeugam, B, Gardezi, S, Ul-Hasan, S, Martin-Hernandez, M, Sisley, M, Modi, S, Antakia, R, Archer, J, Chen, L, Eiben, I, Naylor, M, Osei-Bordom, D, Trenear, R, Bannard-Smith, J, Griffiths, N, Patel, B, Saeed, F, Al-Saraff, Z, Elbayouk, A, Soh, Y, Mather, J, Yusuf, Z, Al-Sarraf, Z, Naja, M, 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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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A., Mills E., Manley L. R., Vutipongsatorn K., Thakral N., Adra M., Khan S. M., Badran A., Ramjeeawon A., Tan H. L., Rye D. S., Rajaraman N., Norman J. G., Solomou G., Baker D. M., Brandao B. D., Stainer B., Onafowokan O. O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Pockney P., Chrimes A., Agarwal A., Zhao J., Jayalath J. M. S. N., Liebenberg P., Khor S., Muddasani T., Dawson A., Taylor N., Stevenson C., Drane A., Pahalawatta U., Lai L. T., Debiasio A., Jung M., Brumfitt C. D., Beh Y. Z., Dudi-Venkata N. N., Lee Y. D., Stewart P., Thirugnanasundralingam V., Muir K., Ng B., Mendis D. M., Robb P. M., Lee H. J., Wyche A. A. B., Davis L. T., Luong J. K., Jegathees T., Coulter-Nile S. M. C. J., Gosselink M. P., Wang Y. L., Maciaszek M., Chrapko P. S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. 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R., Claassen L., Van Vuuren S., Marx M., Kruger C., Weyers J., Lecler J., Nshalati Salvation M., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Muriel P., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Cerdan C., Jimenez Vinas C., Alconchel F., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Abrisqueta J., Esteban Sinovas O., Fairen Oro C., Lopez Otero M., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Paniagua Garcia Senorans M., Figueroa Jimenez S., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. 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L., Castro Diez L., Mosquera Fernandez C., Fernandez P., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Diaz Padillo A., Padilla Zegarra E. D., Franco M., Martinez A., Forero-Torres A., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Alberdi San Roman I., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., Salvador Roses H., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Gomez Romeu N., Merayo Alvarez M., Alonso Batanero E., Cifrian Canales I., Villarejo Campos P., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Estaire Gomez M., Lopes Moreira C. C., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Enriquez-Navascues J. M., Uriol Peralta P., Lima Pinto F., Nunez O'Sullivan S., Serrano Navidad M., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Collado-Roura F., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., Garcia J. M., Gil A., Giordano H. E., Perez Guarinos C. V., Blaser B., Imadalou L., Piazza G., Teixeira H., Pittet O., Gaspar S., Gagliardi B., Haller M. L., Huot A., Yurdaor S. S., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Biyiklioglu O., Kopac O., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Karabulut K., Uyanik A., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Kuyumcu O. F., Kutluk F., Tunc E., Ozmen B. B., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. 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O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., To N., Laurence N., Green C., Frostick R., Khera R., Povey M., Mahapatra S., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Ng M. P. E., Wong R. T. W., Maese S., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Martin H., McClarty C., Sanyal S., Alsaif A., Bhopal S., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Trussell S., Chowdhury H., Alawode D. O. 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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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A., Mills E., Manley L. R., Vutipongsatorn K., Thakral N., Adra M., Khan S. M., Badran A., Ramjeeawon A., Tan H. L., Rye D. S., Rajaraman N., Norman J. G., Solomou G., Baker D. M., Brandao B. D., Stainer B., Onafowokan O. O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Pockney P., Chrimes A., Agarwal A., Zhao J., Jayalath J. M. S. N., Liebenberg P., Khor S., Muddasani T., Dawson A., Taylor N., Stevenson C., Drane A., Pahalawatta U., Lai L. T., Debiasio A., Jung M., Brumfitt C. D., Beh Y. Z., Dudi-Venkata N. N., Lee Y. D., Stewart P., Thirugnanasundralingam V., Muir K., Ng B., Mendis D. M., Robb P. M., Lee H. J., Wyche A. A. B., Davis L. T., Luong J. K., Jegathees T., Coulter-Nile S. M. C. J., Gosselink M. P., Wang Y. L., Maciaszek M., Chrapko P. S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. 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R., Claassen L., Van Vuuren S., Marx M., Kruger C., Weyers J., Lecler J., Nshalati Salvation M., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Muriel P., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Cerdan C., Jimenez Vinas C., Alconchel F., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Abrisqueta J., Esteban Sinovas O., Fairen Oro C., Lopez Otero M., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Paniagua Garcia Senorans M., Figueroa Jimenez S., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. 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L., Castro Diez L., Mosquera Fernandez C., Fernandez P., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Diaz Padillo A., Padilla Zegarra E. D., Franco M., Martinez A., Forero-Torres A., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Alberdi San Roman I., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., Salvador Roses H., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Gomez Romeu N., Merayo Alvarez M., Alonso Batanero E., Cifrian Canales I., Villarejo Campos P., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Estaire Gomez M., Lopes Moreira C. C., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Enriquez-Navascues J. M., Uriol Peralta P., Lima Pinto F., Nunez O'Sullivan S., Serrano Navidad M., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Collado-Roura F., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., Garcia J. M., Gil A., Giordano H. E., Perez Guarinos C. V., Blaser B., Imadalou L., Piazza G., Teixeira H., Pittet O., Gaspar S., Gagliardi B., Haller M. L., Huot A., Yurdaor S. S., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Biyiklioglu O., Kopac O., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Karabulut K., Uyanik A., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Kuyumcu O. F., Kutluk F., Tunc E., Ozmen B. B., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. 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O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., To N., Laurence N., Green C., Frostick R., Khera R., Povey M., Mahapatra S., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Ng M. P. E., Wong R. T. W., Maese S., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Martin H., McClarty C., Sanyal S., Alsaif A., Bhopal S., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Trussell S., Chowdhury H., Alawode D. O. 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P., Giannella A., Santangelo M., Frangella F., Magagnano D., Liberatore P., Rondelli F., Castagnoli G., Bartoli A., Bellochi R., Spaziani A., Conti D., Poponesi V., Trippetti M., Amicucci S., Tazza G., Procacci P., Giovannini F., Basile E., Moschetta G., Cosmi F., Romeo G., Gasparrini M., Virgilio E., Sparta C., Mura F. A., Barmina M., Lorettu A., Rettaroli C., Mastino G., Ruggiu G. V., Mura G. A., Perrone B. A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., Di Mola F. F., D'Ascanio F., Pietroletti R., Di Marco F., Amico A., Schembari E., Puglisi S., Tuminello F., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Braccio B., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Ancans G., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., t Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., Brandsma A. M., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Hawkins R., Jacobson A., Macfater H., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., Mouldey K., Hu R., Matthews C., Aitken E., Walker M., Winstanley J., Miguel I., Martins J., Cunha M. F., Melo J., Veiga D. N., Rachadell J., Amorim E., Vareda R., Roseira J., Americano M., Correia D., Capella V., Moinhos T., Costa F., Gil I., Morgado J., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., O'Connor D. B., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Hoo M., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Gopaul A., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Scanlon K., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., O'Dwyer N., Mana O. C., Gomez H., Riba L., Perez J., Centeno A., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Izquierdo Moreno A., Cuenca Ramirez A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., De La Llave Serralvo A., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Tonchev P., Tamosiunas A., Rottier S. J., Negoi I., Bernado I. R., and Eftychiou S.
- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif
- Published
- 2022
5. First observations of confined fast ions in MAST Upgrade with an upgraded neutron camera
- Author
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Cecconello, Marco, Dolby, I. J., Sperduti, Andrea, Rivero-Rodriguez, J., Ericsson, Göran, Fitzgerald, I, Allan, S. Y., Voller, J., Honey, B., Nizar, B. A., Elmore, S. D., Team, M A S T-U, Cecconello, Marco, Dolby, I. J., Sperduti, Andrea, Rivero-Rodriguez, J., Ericsson, Göran, Fitzgerald, I, Allan, S. Y., Voller, J., Honey, B., Nizar, B. A., Elmore, S. D., and Team, M A S T-U
- Abstract
Spherical tokamaks are key to the successful design of operating scenarios of future fusion reactors in the areas of divertor physics, neutral beam current drive and fast ion physics. MAST Upgrade, which has successfully concluded its first experimental campaign, was specifically designed to address the role of the radial gradient of the fast ion distribution in driving the excitation of magneto-hydrodynamic (MHD) instabilities, such as toroidal Alfven eigenmodes, fish-bones and long-lived mode, thanks to its two tangential neutral beam injection systems, one on the equatorial plane and one that is vertically shifted 65 cm above the equatorial plane. To study the fast ion dynamics in the presence of such instabilities, as well as of sawteeth and neo-classical tearing modes, several fast ion diagnostics were upgraded and new ones added. Among them, the MAST prototype neutron camera (NC) has been upgraded to six, equatorial sight-lines. The first observations of the confined fast ion behavior with the upgraded NC in a wide range of plasma scenarios characterized by on-axis and/or off-axis heating and different MHD instabilities are presented here. The observations presented in this study confirm previous results on MAST but with a higher level of detail and highlight new physics observations unique to the MAST Upgrade. The results presented here confirm the improved performance of the NC Upgrade, which thus becomes one of the key elements, in combination with the rich set of fast ion diagnostics available on the MAST Upgrade, for a more constrained modeling of the fast ion dynamics in fusion reactor relevant scenarios.
- Published
- 2023
- Full Text
- View/download PDF
6. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
- Author
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Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. E., Barai, I., Amin, H., Suresh, S., Sethi, R., Gul, W., Bolton, W., Corbridge, O., Horne, L., Attalla, M., Morley, R., Robinson, C., Hoskins, T., Mcallister, R., Lee, S., Dennis, Y., Nixon, G., Heywood, E., Wilson, H., Ng, L., Samaraweera, S., Mills, A., Doherty, C., Belchos, J., Phan, V., Lim, M., Miller, F. A., Chouari, T., Gardner, T., Goergen, N., Hayes, J. D. B., Macleod, C. S., Mccormack, R., Mckinley, A., Mckinstry, S., Milligan, W., Ooi, L., Rafiq, N. M., Sammut, T., Sinclair, E., Smith, M., Wong, J., Ablett, A. D., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Francis, A. A., Baker, C., Boulton, A. P. R., Collins, J., Copley, H. C., Fearnhead, N., Fox, H., Mah, T., Mckenna, J., Naruka, V., Nigam, N., Nourallah, B., Perera, S., Qureshi, A., Saggar, S., Sun, L., Wang, X., Yang, D. D., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Al-hadithi, A., Caroll, P., Doyle, C., Elangovan, S., Falamarzi, A., Gascon Perai, K., Greenan, E., Jain, D., Lang-Orsini, M., Lim, S., O'Byrne, L., Ridgway, P., Van der Laan, S., Arthur, J., Barclay, J., Bradley, P., Edwin, C., Finch, E., Hayashi, E., Hopkins, M., Kelly, D., Kelly, M., Mccartan, N., Ormrod, A., Pakenham, A., Christy, S., Hayward, J., Hitchen, C., Kishore, A., Martins, T., Philomen, J., Rao, R., Rickards, C., Burns, N., Copeland, M., Durand, C., Dyal, A., Ghaffar, A., Gidwani, A., Grant, M., Gribbon, C., Gruhn, A., Leer, M., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Ahmad, K., Beattie, G., Beatty, M., Campbell, G., Donaldson, G., Graham, S., Holmes, D., Kanabar, S., Liu, H., Mccann, C., Stewart, R., Vara, S., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ajibola-Taylor, O., Andah, E. J. E., Ani, C., Cabdi, N. M. O., Ito, G., Jones, M., Komoriyama, A., Titu, L., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Basra, M., Gallogly, P., Harinath, G., Leong, S. H., Pradhan, A., Siddiqui, I., Zaat, S., Ali, A., Galea, M., Looi, W. L., J. C. K., Ng, Farhan-Alanie, M. M. H., Aitken, G., Nair, M., Aly, M. H., Buari, M., Atkin, G., Azizi, A., Cargill, Z., China, Z., Elliot, J., Jebakumar, R., Lam, J., Mudalige, G., Onyerindu, C., Renju, M., Shankar Babu, V., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Hussain, M., Joji, N., Lovett, B., Mownah, H., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Ali, B., Cresswell, B., Dhillon, A. K., Dupaguntla, Y. S., Hungwe, C., Lowe-Zinola, J. D., Tsang, J. C. H., Wcislo, K., Bevan, K., Cardus, C., Duggal, A., Hossain, S., Mchugh, M., Scott, M., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Chan, F., Evans, R., Gurung, E., Haughey, B., Jacob-Ramsdale, B., Kerr, M., Lee, J., Mccann, E., O'Boyle, K., Reid, N., Kwek, I., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Lau, I. S. F., Hayat, F., Hodgson, S., Johnston, R., Jones, W., Khan, M., Linn, T., Long, S., Seetharam, P., Shaman, S., Smart, B., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anilkumar, A., Davies, J., Griffith, J., Hughes, B., Islam, Y., Kidanu, D., Mushaini, N., Qamar, I., Robinson, H., Schramm, M., Yan Tan, C., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Apperley, H., Billyard, C., Blazeby, J. M., Cannon, S. P., Carse, S., G??pfert, A., Loizidou, A., Parkin, J., Sanders, E., Sharma, S., Slade, G., Telfer, R., Whybrow Huppatz, I., Worley, E., Asif, A., Hullait, R., Quinn, P., Rylance, A., Butt, S., Leathes, J., Chandramoorthy, L., Friend, C., Harris, L., Jain, P., Karim, M. J., Killington, K., Mcgillicuddy, J., Rafferty, C., Rahunathan, N., Rayne, T., Varathan, Y., Verma, N., Zanichelli, D., Arneill, M., Brown, F., Campbell, B., Crozier, L., Henry, J., Mccusker, C., Prabakaran, P., Wilson, R., Karelia, S., Clements, J. M., Rainey, M., Asif, U., Connor, M., Dindyal, S., Math, N., Pagarkar, A., Saleem, H., Seth, I., Standfield, N., Swartbol, T., Adamson, R., Choi, J. E., El Tokhy, O., Ho, W., Javaid, N. R., Mehdi, A. S., Menon, D., Plumptre, I., Sturrock, S., Turner, J., Warren, O., Joshi, N., Rahman, A., Gallagher, M., Crane, E., Ferris, B., Gadsby, C., Smallwood, J., Vipond, M., Wilson, V., Amarnath, T., Doshi, A., Gregory, C., Kandiah, K., Powell, B., Spoor, H., Toh, C., Vizor, R., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Smith, E., Common, M., Dunleavy, K., Harris, S., Luo, C., Mesbah, Z., Prem Kumar, A., Redmond, A., Skulsky, S., Walsh, T., Daly, D., Deery, L., Epanomeritakis, E., Harty, M., Kane, D., Khan, K., Mackey, R., Mcconville, J., Mcginnity, K., Wong, H. L., Ang, A., Kee, J. Y., Leung, E., Norman, S., Palaniappan, S. V., Partha Sarathy, P., Yeoh, T., Frost, J., Hazeldine, P., Jones, L., Karbowiak, M., Macdonald, C., Mutarambirwa, A., Omotade, A., Runkel, M., Ryan, G., Sawers, N., Searle, C., Vig, S., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Mcauliffe, O., Ahmad, A., Mcgartland, R., Sim, R., Song, A., Wayman, J., Brown, R., Chang, L. H., Concannon, K., Crilly, C., Arnold, T. J., Burgin, A., Cadden, F., Choy, C. H., Coleman, M., Lim, D., Luk, J., Mahankali-Rao, P., Prudence-Taylor, A. J., Ramakrishnan, D., Russell, J., Fawole, A., Gohil, J., Green, B., Hussain, A., Mcmenamin, L., Tang, M., Azmi, F., Benchetrit, S., Cope, T., Haque, A., Harlinska, A., Holdsworth, R., Ivo, T., Martin, J., Nisar, T., Patel, A., Sasapu, K., Trevett, J., Vernet, G., Aamir, A., Bird, C., Durham-Hall, A., Gibson, W., Hartley, J., May, N., Maynard, V., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Johnson, S., McDonald Wood, C., O'Brien, M., Orbell, J., Stringfellow, T. D., Tenters, F., Tresidder, S., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Cheung, W., Grant, A., Tod, N., Yi Tew, Z., Suchdev, N., Wei Lim, S., Bews-Hair, M., Lim, Z. H., Lim, S. W., Vella-Baldacchino, M., Auckburally, S., Chopada, A., Easdon, S., Goodson, R., Mccurdie, F., Narouz, M., Radford, A., Rea, E., Taylor, O., Yu, T., Sookramanien, S. R., Chan, A., Bointas, G., Alfa-Wali, M., Amani, L., Auluck, I., Bruce, P., Emberton, J., Kumar, R., Lagzouli, N., Mehta, A., Murtaza, A., Raja, M., Dennahy, I. S., Frew, K., Given, A., Y. Y., He, Karim, M. A., Macdonald, E., Mcdonald, E., Mcvinnie, D., S. K., Ng, Pettit, A., Berthaume-Hawkins, S. D., Charnley, R., Fenton, K., Jones, D., Murphy, C., J. Q., Ng, Reehal, R., Seraj, S. S., Shang, E., Tonks, A., White, P., Yeo, A., Paul, M., Ward, K. L., Bagnall, M., Chong, P., Gabriel, R., Patel, N., Richardson, E., Symons, L., Aubrey-Jones, D., Dawood, S., Dobrzynska, M., Faulkner, S., Griffiths, H., Mahmood, F., Perry, M., Power, A., Simpson, R., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Brobbey, P., Burrows, A., Elder, P., Ganyani, R., Horseman, C., Hurst, P., Mann, H., Marimuthu, K., Mcbride, S., Pilsworth, E., Powers, N., Stanier, P., Obukofe, R., Polson, R., Mason, D., Mackenzie, E., Innes, R., Kersey, T., Kopczynska, M., Langasco, N., Rajagopal, R., Russell, C., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Imam, L., Atkins, B., Beasley, W., Cheng Lim, Z., Gill, A., Li Ang, H., Williams, H., Yogeswara, T., Drury, D. J., James, S. J., Barnett, R., Teasdale, A. B., Richardson, E. T. J., Thomas, D. A., Williams, R. L., Najabat-Lattif, H. F., Akram, B., Carter, R., Fam, M., Fong, J., Latter, J., Long, M., Mackinnon, S., Mckenzie, C., Osmanska, J., Raghuvir, V., Shafi, A., Tsang, K., Walker, L., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Bountra, K., Coldicutt, O., Fletcher, D., Hudson, S., Iqbal, S., Lopez Bernal, T., Martin, J. W. 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L., Tseu, B., Wei, R., Yang, N., Britton, N., Leinhardt, D., Mahfooz, M., Palkhi, A., Price, M., Sheikh, S., Barker, M., Bowley, D., Cant, M., Datta, U., Farooqi, M., Lee, A., Morley, G., Naushad Amin, M., Parry, A., Patel, S., Strang, S., Yoganayagam, N., Guruswamy, M., Beedham, W., Brazier, E., Elghobashy, M., Bajaj, M., Etel, E., Adlan, A., Chandramoorthy, S., Choudhary, Y., Das, K., Feldman, M., France, B., Grace, R., Puddy, H., Soor, P., Kisiel, A., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Ali, M., Dhillon, P., Faraj, A., Gerard, L., Glover, M., Imran, H., Kim, S., Patrick, Y., Peto, J., Prabhudesai, A., Tang, A., Vadgama, N., Dhaliwal, R., Ecclestone, T., Harris, A., Ong, D., Patel, D., Philp, C., Stewart, E., Wang, L., Wong, E., Xu, Y., Ashaye, T., Fozard, T., Galloway, F., Kaptanis, S., Mistry, P., Nguyen, T., Olagbaiye, F., Osman, M., Philip, Z., Rembacken, R., Tayeh, S., Theodoropoulou, K., Liu, F. Y., Arnold, A., Pedersen, A. 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V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. 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P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. P., Scaramuzzo, R., Larcinese, A., Fioriti, C., Picone, E., Nardi, M., Di Candido, F., Spinelli, A., Marco, M., Bevilacqua, M., Maroli, A., Colombo, F., Cigognini, M., Zaffaroni, G., Maffioli, A., Colombo, S., Bondurri, A., Sampietro, G., Foschi, D., Perrone, G., Bonati, E., Aresu, S., Saba, A., Biancafarina, A., Angelini, M., Andolfi, E., Miranda, E., Scricciolo, M., Provenza, G., Cavallina, G., Frezza, B., Fontani, A., Malatesti, R., Pellican??, G. A., Ceccarelli, G., Canonico, G., Falsetti, E., Pagnanelli, M., De Nardi, P., Rosati, R., Marcocci, G., Vignali, A., Quattromani, R., Curletti, G., Galleano, R., Malerba, M., Percivale, A., Ghazouani, O., Reggiani, L., Spirito, C., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Moretto, G., Bacchion, M., Casaril, A., Inama, M., Creciun, M., Vitali, M., Cillara, N., Mosino, L., Peddis, M., Melis, S., De Donno, G., Aru, A. C., Loche, G. A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Gr??ter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, ??., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., Psychiatry, Surgery, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Kanta-Häme Central Hospital Hämeenlinna, Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, Miller, F, Chouari, T, Gardner, T, Goergen, N, Hayes, J, Macleod, C, Mccormack, R, Mckinley, A, Mckinstry, S, Milligan, W, Ooi, L, Rafiq, N, Sammut, T, Sinclair, E, Smith, M, Wong, J, Ablett, A, Tie-Gill, T, Ramsay, G, De Paola, L, Mcguckin, S, Alshakhs, A, Ahmeidat, A, Francis, A, Baker, C, Boulton, A, Collins, J, Copley, H, Fearnhead, N, Fox, H, Mah, T, Mckenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, Yang, D, Ali, Z, Mullarkey, L, Walshe, R, Lewis, E, Berry, B, Moneim, J, Mookerjee, S, Al-Hadithi, A, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Gascon Perai, K, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, Mccartan, N, Ormrod, A, Pakenham, A, Christy, S, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, 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J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., Ng, S. Y., Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., Pös, M., Adel, A., Sotona, O., Bartoš, M., Amjad, T., Malý, O., Berec, S., Hanušová, M., Hurný, M., Örhalmi, J., Sørensen, J. 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A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Figà, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Truškovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., Müller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., 't Hart, E., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, É., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG
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renal failure ,cohort studies ,humans ,kidney ,postoperative complications ,prognosis ,prospective studies ,retrospective studies ,risk assessment ,risk factors ,acute kidney injury ,digestive system surgical procedures ,Prognosi ,Acute Kidney Injury/diagnosis ,Digestive System Surgical Procedures/adverse effects ,3121 Internal medicine ,Kidney ,Risk Assessment ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,Postoperative Complications ,Retrospective Studie ,Risk Factors ,Gastrointestinal Surgery ,Humans ,preoperative care ,Prognostic Model ,Prospective Studies ,Digestive System Surgical Procedures ,Retrospective Studies ,Science & Technology ,Risk Factor ,MORTALITY ,General Medicine ,STARSurg Collaborative and EuroSurg Collaborative ,Acute Kidney Injury ,Prognosis ,surgical procedures ,Prospective Studie ,aki ,OAKS ,Postoperative Complications/etiology ,colorectal surgery ,Surgery ,Postoperative Complication ,Cohort Studie ,Life Sciences & Biomedicine ,Human - Abstract
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
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- 2022
7. Design elements and first data from a new Doppler backscattering system on the MAST-U spherical tokamak
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Rhodes, T. L., primary, Michael, C. A., additional, Shi, P., additional, Scannell, R., additional, Storment, S., additional, Pratt, Q., additional, Lantsov, R., additional, Fitzgerald, I., additional, Hall-Chen, V. H., additional, Crocker, N. A., additional, and Peebles, W. A., additional
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- 2022
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8. The 2.5 MeV neutron flux monitor for MAST
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Cecconello, M., Sangaroon, S., Conroy, S., Donato, M., Ericsson, G., Marini-Bettolo, C., Ronchi, R., Stro¨m, P., Weiszflog, M., Wodniak, I., Turnyanskiy, M., Akers, R., Cullen, A., Fitzgerald, I., McArdle, G., Pacoto, C., and Thomas-Davies, N.
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- 2014
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9. Predicting antipsychotic-induced weight gain in first episode psychosis – a protocol for a field-wide systematic review of non-genetic prognostic factor studies
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Fitzgerald, I, Crowley, EK, Byrne, A, O'Connell, J, Ensor, J, Ni Dhubhlaing, C, O'Dwyer, S, and Sahm, LJ
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BF ,R1 ,RA - Published
- 2022
10. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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R Ahmed, W U, Bhatia, S, A McLean, K, Khaw, R, Baker, D, K Kamarajah, S, Bell, S, Nepogodiev, D, M Harrison, E, C Glasbey, J, Borakati, A, Burke, J, M Drake, T, F Bath, M, A Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, E Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, D Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, J Chapman, S, Pata, F, Pellino, G, Sgrò, A, Soares, A, van Elst, T, Van Straten, S, H Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, S Brown, F, Teo, R, Y Sim, D P, E Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, A Miller, F, Chouari, T, Gardner, 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Galata, C, Karampinis, I, Thäwel, T, M Seckler, A, Kerem, C, Durdevic, S, Herrle, F, Artioli, E, Giaccari, S, Nevoso, V, Schimera, A, Marino, S, Resta, G, Ongaro, D, Baronio, G, Raimondo, S, Casiraghi, S, Salvadori, R, Armellini, A, Vulcano, I, Bertilone, E, Pintabona, G, Viscosi, F, Mazzeo, C, Olivieri, M, Belluco, C, D Antona, A, Basso, S, Frattalone, M, Marino, F, Carbone, F, Incollingo, P, M Romano, F, Anania, M, Pulighe, F, Cruccu, A, L Murru, M, Massaiu, C, Balestra, F, Pazzona, M, De Nisco, C, P Gusai, G, Giannella, A, Santangelo, M, Frangella, F, Magagnano, D, Liberatore, P, Rondelli, F, Castagnoli, G, Bartoli, A, Bellochi, R, Spaziani, A, Conti, D, Poponesi, V, Trippetti, M, Amicucci, S, Tazza, G, Procacci, P, Giovannini, F, Basile, E, Moschetta, G, Cosmi, F, Romeo, G, Gasparrini, M, Virgilio, E, Sparta, C, A Mura, F, Barmina, M, Lorettu, A, Rettaroli, C, Mastino, G, V Ruggiu, G, A Mura, G, A Perrone, B, De Angelis, M, Mereu, A, Adamo, V, Bianco, C, Ricciardiello, M, Campanaro, C, Panaccio, P, M Esposito, L, F Di Mola, F, D'Ascanio, F, Pietroletti, R, Di Marco, F, Amico, A, Schembari, E, Puglisi, S, Tuminello, F, Figà, F, Caiazzo, A, Selvaggi, L, Capozzolo, A, Braccio, B, Truškovs, A, Bartnick, A, Malcevs, E, J Machatschek, M, Alm, J, Lapsa, S, Delorme, M, Zeynalov, F, Larnovskis, J, Sauka, J, Bodrov, D, Gailumsis, R, M Wiemann, A, L Müller, N, Jelovskis, I, Deksnis, D, Bauermeister Potts, O, Slimbajevs, T, Ancans, G, Dulskas, A, Kuliavas, J, Kavaliauskas, P, Kavaliauskaite, R, Te Molder, L, Tromp, J, Matthee, E, M Tissen, Y, Brinkhuis, E, S de Vries, H, 't Hart, E, Beckers, K, Bekker, Y, Kakar, S, C van Smaalen, T, C Veen, O, A Dingemans, S, C van den Brink, L, J Vijgen, G H E, F van de Voort, E M, van der Pool, A, C van Rest, K L, Haak, T, C Gordinou de Gouberville, M, Saleh, S, A Mens, M, M Hoeks, E, Nieuwenhuizen, S, M Brandsma, A, M van Praag, E, Westerduin, E, M Smit, M P C, J van der Lely, S, de Ruiter, A, Ribbers, T, M Aarts, C A, S Tulek, M, de Jonge, J, Kocak, S, J Alqethami, H, Constansia, R, C van Elst, P, W Tissink, M, Azzahhafi, J, Bofarid, S, Kip, M, Saleh, W, Franssen, S, L Boon, C, M Franssen, R J, Romaen, I, F Jense, M T, D'Souza, J, Pascoe, R, Scott, A, Stark, E, Mulholland, K, K Lau, W, Smith, B, B Adams, S I, Shah, N, Ling, E, Young, J, Hawkins, R, Jacobson, A, Macfater, H, Stanfield, B, Henderson, N, Chuang, A, Maskill, L, Ker, H, Mouldey, K, Hu, R, Matthews, C, Aitken, E, Walker, M, Winstanley, J, Miguel, I, Martins, J, F Cunha, M, Melo, J, N Veiga, D, Rachadell, J, Amorim, E, Vareda, R, Roseira, J, Americano, M, Correia, D, Capella, V, Moinhos, T, Costa, F, Gil, I, Morgado, J, Varghese, S, Boyle, E, Aljohmani, L, Alexander, J, Graziadei, V, Mccaughey, C, Jain, A, B O'Connor, D, Ramanayake, H, Sabnani, R, F Colon, L, Bansal, N, Stephens, I, Tan, R, Hoo, M, Doherty, G, Fenn, S, Mulhare, E, Walsh, M, Leavey, C, Costigan, O, Griffin, S, Dockry, É, Khogali, E, K Aly, A, Mcphedran, R, O'Gorman, D, Vermeulen, D, Gopaul, A, R Pentony, A, L Piong, C, Nossier, R, Hanna, J, Sabir, K, Y Eow, S, Ladak, N, Boersma, D, J Kamath, P, W Soh, T B, H Dyer, A, Y Chee, S, H Tan, I X, Kelliher, A, Scanlon, K, Adeusi, L, Howarth, N, Mccawley, N, O'Neill, A, R Jones, M, Saleh, R, Singh, A, O'Dwyer, N, C Mana, O, Gomez, H, Riba, L, Perez, J, Centeno, A, Ortega, C, E Ossola, M, Camarero, E, Martínez Illán, M, Aranda García, L, Lázaro Cardona, M, Montalvo Olmedo, C, Izquierdo Moreno, A, Cuenca Ramírez, A, Margarida, A, Pando, B, Liquete Marín, L, Pérez Calle, M, J Ramos Cordero, M, Sagredo Cuartango, A, Sánchez, E, Marcos Rodrigo, A, Fernandez, A, Curtis, C, Bosch, M, Triguero, D, Bosch Ramírez, M, De La Llave Serralvo, A, J Sánchez, M, Martín-Borregón, P, Quevedo, A, Martínez, J, M Marín, J, Rodríguez, P, Esteban Avendaño, I, Jiménez Relimpio, C, Lancho Lavilla, P, Blanco Bartolomé, I, Gómez Cano, I, Blasco Andrés, C, Abad-Motos, A, Marínez-Hurtado, E, Salvachua-Fernández, R, Muniesa, C, Avelino, L, Cholewa, H, Sancho-Muriel, J, Navasquillo, M, Navío, A, Abelló, D, De Jesus, M, Alvarez, E, Kefleyesus, A, Bugmann, A, M Piotet, L, Meijers, L, Tonchev, P, Tamosiunas, A, J Rottier, S, Negoi, I, R Bernado, I, Eftychiou, S, and L Lorenzon (ORCID:0000-0001-6736-0383)
- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study ('IMAGINE') of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study ('Tayside') in major abdominal surgery (2011-2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655-0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323-0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif
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- 2022
11. Introduction
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FitzGerald, I., Pastan, I., Robertus, J., Compans, R. W., editor, Cooper, M., editor, Hogle, J. M., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Seadler, H., editor, Vogt, P. K., editor, Wagner, H., editor, and Frankel, Arthur E., editor
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- 1998
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12. Sensitivity, specificity and inter-test agreement of interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals with advanced immunodeficiency: O330
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Ni Cheallaigh, C., Grace, J., Fitzgerald, I., Singh, G., OʼDea, S., Gibbons, N., Rogers, T., Keane, J., Clarke, S., and Bergin, C.
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- 2010
13. Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study
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Nepogodiev, D, Walker, K, Glasbey, JC, Drake, TM, Borakati, A, Kamarajah, S, McLean, K, Khatri, C, Arulkumaran, N, Harrison, EM, Fitzgerald, JE, Cromwell, D, Prowle, J, Bhangu, A, Bath, MF, Claireaux, HA, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Burke, J, Bell, S, Duthie, F, Hughes, J, Pinkney, TD, Richards, T, Thomas, M, Dynes, K, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Brown, FS, Teo, R, Sim, DPY, Logan, AE, Barai, I, Amin, H, Suresh, S, Sethi, R, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Hoskins, T, McAllister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Chouari, T, Gardner, T, Goergen, N, Hayes, JDB, MacLeod, CS, McCormack, R, McKinley, A, McKinstry, S, Milligan, W, Ooi, L, Rafiq, NM, Sammut, T, Sinclair, E, Smith, M, Baker, C, Boulton, APR, Collins, J, Copley, HC, Fearnhead, N, Fox, 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Barnfield, J, Ben-Gal, O, Bloom, I, Gharatya, A, Khodatars, K, Merchant, N, Moonan, A, Moore, M, Patel, K, Spiers, H, Sundaram, K, Black, J, Chadwick, H, Huisman, L, Ingram, H, Martin, L, Metcalfe, M, Sangal, P, Seehra, J, Thatcher, A, Venturini, S, Whitcroft, I, Afzal, Z, Brown, S, Gani, A, Gomaa, A, Hussein, N, Oh, SY, Pazhaniappan, N, Sharkey, E, Sivagnanasithiyar, T, Williams, C, Yeung, J, Cruddas, L, Gurjar, S, Pau, A, Prakash, R, Randhawa, R, Chen, L, Eiben, I, Naylor, M, Osei-Bordom, D, Trenear, R, Bannard-Smith, J, Griffiths, N, Patel, BY, Saeed, F, Abdikadir, H, Bennett, M, Church, R, Clements, SE, Court, J, Delvi, A, Hubert, J, Macdonald, B, Mansour, F, Patel, RR, Perris, R, Small, S, Betts, A, Brown, N, Chong, A, Croitoru, C, Grey, A, Hickland, P, Ho, C, Hollington, D, McKie, L, Nelson, AR, Stewart, H, Eiben, P, Nedham, M, Ali, I, Brown, T, Hunt, C, Joyner, C, McAlinden, C, Rogers, D, Thachettu, A, Tyson, N, Vaughan, R, Yasin, T, Andrew, K, Bhamra, N, Leong, S, Mistry, R, Noble, H, Rashed, F, Walker, NR, Watson, L, Worsfold, M, Yarham, E, Arshad, A, Barmayehvar, B, Cato, L, Chan-lam, N, Do, V, Leong, A, Sheikh, Z, Zheleniakova, T, Coppel, J, Hussain, ST, Mahmood, R, Nourzaie, R, Sheik-Ali, S, Thomas, A, Alagappan, A, Ashour, R, Bains, H, Diamond, J, Gordon, J, Ibrahim, B, Khalil, M, Mittapalli, D, Neo, YN, Patil, P, Peck, FS, Reza, N, Swan, I, Whyte, M, Chaudhry, S, Hernon, J, Khawar, H, O'Brien, J, Pullinger, M, Rothnie, K, Ujjal, S, Bhatte, S, Curtis, J, Green, S, Mayer, A, Watkinson, G, Chapple, K, Hawthorne, T, Khaliq, M, Majkowski, L, Malik, TAM, Mclauchlan, K, En, BNW, O'Connor, T, Parton, S, Robinson, SD, Saat, M, Shurovi, BN, Varatharasasingam, K, Ward, AE, Behranwala, K, Bertelli, M, Cohen, J, Duff, F, Fafemi, O, Gupta, R, Manimaran, M, Mayhew, J, Peprah, D, Wong, MHY, Farmer, N, Houghton, C, Kandhari, N, Ladha, D, Mayes, J, McLennan, F, Panahi, P, Seehra, H, Agrawal, R, Ahmed, I, Ali, S, Birkinshaw, F, Choudhry, M, Gokani, S, Harrogate, S, Jamal, S, Nawrozzadeh, F, Swaray, A, Szczap, A, Warusavitarne, J, Abdalla, M, Asemota, N, Cullum, R, Hartley, M, Maxwell-Armstrong, C, Mulvenna, C, Phillips, J, Yule, A, Ahmed, L, Clement, KD, Craig, N, Elseedawy, E, Gorman, D, Kane, L, Livie, J, Livie, V, Moss, E, Naasan, A, Ravi, F, Shields, P, Zhu, Y, Archer, M, Cobley, H, Dennis, R, Downes, C, Guevel, B, Lamptey, E, Murray, H, Radhakrishnan, A, Saravanabavan, S, Sardar, M, Shaw, C, Tilliridou, V, Wright, R, Ye, W, Alturki, N, Helliwell, R, Jones, E, Lambotharan, S, Scott, K, Sivakumar, R, Victor, L, Boraluwe-Rallage, H, Froggatt, P, Haynes, S, Hung, YMA, Keyte, A, Matthews, L, Evans, E, Haray, P, John, I, Mathivanan, A, Morgan, L, Oji, O, Okorocha, C, Rutherford, A, Stageman, N, Tsui, A, Whitham, R, Amoah-Arko, A, Cecil, E, Dietrich, A, Fitzpatrick, H, Guy, C, Hair, J, Hilton, J, Jawad, L, McAleer, E, Taylor, Z, Yap, J, Akhbari, M, Debnath, D, Dhir, T, Elbuzidi, M, Elsaddig, M, Glace, S, Khawaja, H, Koshy, R, Lal, K, Lobo, L, McDermott, A, Meredith, J, Qamar, MA, Vaidya, A, Acquaah, F, Barfi, L, Carter, N, Gnanappiragasam, D, Ji, C, Kaminski, F, Lawday, S, Mackay, K, Sulaiman, SK, Webb, R, Ananthavarathan, P, Dalal, F, Farrar, E, Hashemi, R, Hossain, M, Jiang, J, Kiandee, M, Lex, J, Mason, L, Matthews, JH, McGeorge, E, Modhwadia, S, Pinkney, T, Radotra, A, Rickard, L, Rodman, L, Sales, A, Tan, KL, Bachi, A, Bajwa, DS, Brown, LR, Butler, A, Calciu, A, Davies, E, Gardner, I, Girdlestone, T, Ikogho, O, Keelan, G, O'Loughlin, P, Tam, J, Elias, J, Ngaage, M, Thompson, J, Bristow, S, Brock, E, Davis, H, Pantelidou, M, Sathiyakeerthy, A, Singh, K, Chaudhry, A, Dickson, G, Glen, P, Gregoriou, K, Hamid, H, Mclean, A, Mehtaji, P, Neophytou, G, Potts, S, Belgaid, DR, Durno, J, Ghailan, N, Henshaw, V, Nazir, UR, Omar, I, Riley, BJ, Roberts, J, Smart, G, Van Winsen, K, Bhatti, A, Chan, M, D'Auria, M, Keshvala, C, Michaelidou, M, Simmonds, L, Smith, C, Wimalathasan, A, Abbas, J, Cairns, C, Chin, YR, Connelly, A, Moug, S, Nair, A, Svolkinas, D, Coe, P, Subar, D, Wang, H, Zaver, V, Brayley, J, Cookson, P, Cunningham, L, Gaukroger, A, Ho, M, Hough, A, King, J, O'Hagan, D, Widdison, A, Brown, B, Chavan, A, Francis, S, Hare, L, Lund, J, Malone, N, Mavi, B, McIlwaine, A, Rangarajan, S, Abuhussein, N, Campbell, HS, Daniels, J, Fitzgerald, I, Mansfield, S, Pendrill, A, Robertson, D, Smart, YW, Teng, T, Yates, J, Belgaumkar, A, Katira, A, Kossoff, J, Kukran, S, Laing, C, Mathew, B, Mohamed, T, Myers, S, Novell, R, Phillips, BL, Turlejski, T, Turner, S, Varcada, M, Warren, L, Wynell-Mayow, W, Linley-Adams, L, Osborn, G, Saunders, M, Spencer, R, Srikanthan, M, Tailor, S, Tullett, A, Al-Masri, S, Carr, G, Ebhogiaye, O, Heng, S, Manivannan, S, Manley, J, McMillan, LE, Peat, C, Phillips, B, Thomas, S, Whewell, H, Williams, G, Bienias, A, Cope, EA, Courquin, GR, Day, L, Garner, C, Gimson, A, Harris, C, Markham, K, Moore, T, Nadin, T, Phillips, C, Subratty, SM, Brown, K, Dada, J, Durbacz, M, Filipescu, T, Harrison, E, Kennedy, ED, Khoo, E, Kremel, D, Lyell, I, Pronin, S, Tummon, R, Ventre, C, Walls, L, Wootton, E, Akhtar, A, El-Sawy, D, Farooq, M, Gaddah, M, Katsaiti, I, Khadem, N, Leong, K, Williams, I, Chean, CS, Chudek, D, Desai, H, Ellerby, N, Hammad, A, Malla, S, Murphy, B, Oshin, O, Popova, P, Rana, S, Ward, T, Abbott, TEF, Akpenyi, O, Edozie, F, El Matary, R, English, W, Jeyabaladevan, S, Morgan, C, Naidu, V, Nicholls, K, Peroos, S, Sansome, S, Torrance, HD, Townsend, D, Brecher, J, Fung, H, Kazmi, Z, Outlaw, P, Pursnani, K, Ramanujam, N, Razaq, A, Sattar, M, Sukumar, S, Tan, TSE, Chohan, K, Dhuna, S, Haq, T, Kirby, S, Lacy-Colson, J, Logan, P, Malik, Q, McCann, J, Mughal, Z, Sadiq, S, Sharif, I, Shingles, C, Simon, A, Burnage, S, Chan, SSN, Craig, ARJ, Duffield, J, Dutta, A, Eastwood, M, Iqbal, F, Mahmood, W, Patel, C, Qadeer, A, Robinson, A, Rotundo, A, Schade, A, Slade, RD, De Freitas, M, Kinnersley, H, McDowell, E, Moens-Lecumberri, S, Ramsden, J, Rockall, T, Wiffen, L, Wright, S, Bruce, C, Francois, V, Hamdan, K, Limb, C, Lunt, AJ, Manley, L, Marks, M, Phillips, CFE, Agnew, CJF, Barr, CJ, Benons, N, Hart, SJ, Kandage, D, Krysztopik, R, Mahalingam, P, Mock, J, Rajendran, S, Stoddart, MT, Clements, B, Gillespie, H, McDougall, R, Murray, C, O'Loane, R, Periketi, S, Tan, S, Amoah, R, Bhudia, R, Dudley, B, Gilbert, A, Griffiths, B, Khan, H, McKigney, N, Roberts, B, Samuel, R, Seelarbokus, A, Stubbing-Moore, A, Thompson, G, Williams, P, Ahmed, N, Akhtar, R, Chandler, E, Chappelow, I, Gil, H, Gower, T, Kale, A, Lingam, G, Rutler, L, Sellahewa, C, Sheikh, A, Stringer, H, Taylor, R, Aglan, H, Ashraf, MR, Choo, S, Das, E, Epstein, J, Gentry, R, Mills, D, Poolovadoo, Y, Ward, N, Bull, K, Cole, A, Hack, J, Khawari, S, Lake, C, Mandishona, T, Perry, R, Sleight, S, Sultan, S, Thornton, T, Williams, S, Arif, T, Castle, A, Chauhan, P, Chesner, R, Eilon, T, Kambasha, C, Lock, L, Loka, T, Mohammad, F, Motahariasl, S, Roper, L, Sadhra, SS, Toma, T, Wadood, Q, Yip, J, Ainger, E, Busti, S, Cunliffe, L, Flamini, T, Gaffing, S, Moorcroft, C, Peter, M, Simpson, L, Stokes, E, Stott, G, Wilson, J, York, J, Yousaf, A, Brown, M, Goaman, A, Hodgson, B, Ijeomah, A, Iroegbu, U, Kaur, G, Lowe, C, Mahmood, S, Sattar, Z, Sen, P, Szuman, A, Abbas, N, Al-Ausi, M, Anto, N, Bhome, R, Eccles, L, Elliott, J, Hughes, EJ, Jones, A, Karunatilleke, AS, Knight, JS, Manson, CCF, Mekhail, I, Michaels, L, Noton, TM, Okenyi, E, Reeves, T, Yasin, IH, Banfield, DA, Harris, R, Mason-Apps, C, Roe, T, Sandhu, J, Shafiq, N, Stickler, E, Tam, JP, Williams, LM, Ainsworth, P, Boualbanat, Y, Doull, C, Egan, E, Evans, L, Hassanin, K, Ninkovic-Hall, G, Odunlami, W, Shergill, M, Traish, M, Cummings, D, Kershaw, S, Ong, J, Reid, F, Toellner, H, Alwandi, A, Amer, M, George, D, Haynes, K, Hughes, K, Peakall, L, Premakumar, Y, Punjabi, N, Ramwell, A, Sawkins, H, Ashwood, J, Baker, A, Baron, C, Bhide, I, Blake, E, De Cates, C, Esmail, R, Hosamuddin, H, Kapp, J, Nguru, N, Thomson, F, Ahmed, H, Aishwarya, G, Al-Huneidi, R, Aziz, R, Burke, D, Clarke, B, Kausar, A, Maskill, D, Mecia, L, Myers, L, Smith, ACD, Walker, G, Wroe, N, Donohoe, C, Gibbons, D, Jordan, P, Keogh, C, Kiely, A, Lalor, P, McCrohan, M, Powell, C, Foley, MP, Reynolds, J, Silke, E, Thorpe, O, Kong, JTH, White, C, Ali, Q, Dalrymple, J, Ge, Y, Luo, RS, Paine, H, Paraskeva, B, Parker, L, Pillai, K, Salciccioli, J, Selvadurai, S, Sonagara, V, Springford, LR, Tan, L, Appleton, S, Leadholm, N, Zhang, Y, Ahern, D, Cotter, M, Cremen, S, Durrigan, T, Flack, V, Hrvacic, N, Jones, H, Jong, B, Keane, K, O'Connell, PR, O'Sullivan, J, Pek, G, Shirazi, S, Barker, C, Brown, A, Carr, W, Chen, Y, Guillotte, C, Harte, J, Kokayi, A, Lau, K, McFarlane, S, Morrison, S, Broad, J, Kenefick, N, Makanji, D, Printz, V, Saito, R, Thomas, O, Breen, H, Kirk, S, Kong, CH, O'Kane, A, Eddama, M, Engledow, A, Freeman, SK, Frost, A, Goh, C, Lee, G, Poonawala, R, Suri, A, Taribagil, P, Brown, H, Christie, S, Dean, S, Gravell, R, Haywood, E, Holt, F, Rabiu, R, Roscoe, HW, Shergill, S, Sriram, A, Sureshkumar, A, Tan, LC, Tanna, A, Vakharia, A, Bhullar, S, Brannick, S, Dunne, E, Frere, M, Kerin, M, Kumar, KM, Pratumsuwan, T, Quek, R, Salman, M, Van Den Berg, N, Wong, C, Ahluwalia, J, Bagga, R, Borg, CM, Calabria, C, Draper, A, Farwana, M, Khan, A, Mazza, M, Pankin, G, Sait, MS, Sandhu, N, Virani, N, Woodhams, K, Croghan, N, Ghag, S, Hogg, G, Ismail, O, John, N, Nadeem, K, Naqi, M, Noe, SM, Sharma, A, Begum, F, Best, R, Collishaw, A, Glasbey, J, Golding, D, Gwilym, B, Harrison, P, Jackman, T, Lewis, N, Luk, YL, Porter, T, Potluri, S, Stechman, M, Tate, S, Thomas, D, Walford, B, Auld, F, Bleakley, A, Johnston, S, Jones, C, Khaw, J, Milne, S, O'Neill, S, Singh, KKR, Swan, A, Thorley, N, Yalamarthi, S, Yin, ZD, Balian, V, Bana, R, Clark, K, Livesey, C, McLachlan, G, Mohammad, M, Pranesh, N, Richards, C, Ross, F, Sajid, M, Brooke, M, Francombe, J, Gresly, J, Hutchinson, S, Kerrigan, K, Matthews, E, Nur, S, Parsons, L, Sandhu, A, Vyas, M, White, F, Zulkifli, A, Zuzarte, L, Al-Mousawi, A, Arya, J, Azam, S, Yahaya, AA, Gill, K, Hallan, R, Hathaway, C, Leptidis, I, McDonagh, L, Mitrasinovic, S, Mushtaq, N, Pang, N, Peiris, GB, Rinkoff, S, Chan, L, Christopher, E, Farhan-Alanie, MMH, Gonzalez-Ciscar, A, Graham, CJ, Lim, H, McLean, KA, Paterson, HM, Rogers, A, Roy, C, Rutherford, D, Smith, F, Zubikarai, G, Al-Khudairi, R, Bamford, M, Chang, M, Cheng, J, Hedley, C, Joseph, R, Mitchell, B, Rothwell, L, Siddiqui, A, Smith, J, Taylor, K, Wright, OW, Baryan, HK, Boyd, G, Conchie, H, Cox, L, Gardner, S, Hill, N, Krishna, K, Lakin, F, Scotcher, S, Alberts, J, Asad, M, Barraclough, J, Campbell, A, Marshall, D, Wakeford, W, Cronbach, P, D'Souza, F, Gammeri, E, Houlton, J, Hall, M, Kethees, A, Patel, R, Perera, M, Shaid, M, Webb, E, Beattie, S, Chadwick, M, El-Taji, O, Haddad, S, Mann, M, Patel, M, Popat, K, Rimmer, L, Riyat, H, Smith, H, Anandarajah, C, Cipparrone, M, Desai, K, Gao, C, Goh, ET, Howlader, M, Jeffreys, N, Karmarkar, A, Mathew, G, Mukhtar, H, Ozcan, E, Renukanthan, A, Sarens, N, Sinha, C, Woolley, A, Bogle, R, Komolafe, O, Loo, F, Waugh, D, Zeng, R, Crewe, A, Mathias, J, Owen, A, Prior, A, Saunders, I, Crilly, L, McKeon, J, Ubhi, HK, Adeogun, A, Carr, R, Davison, C, Devalia, S, Hayat, A, Karsan, RB, Osborne, C, Weegenaar, C, Wijeyaratne, M, Babatunde, F, Barnor-Ahiaku, E, Chitsabesan, P, Dixon, O, Hall, N, Ilenkovan, N, Mackrell, T, Nithianandasivam, N, Orr, J, Palazzo, F, Saad, M, Sandland-Taylor, L, Sherlock, J, Ashdown, T, Chandler, S, Garsaa, T, Lloyd, J, Loh, SY, Ng, S, Perkins, C, Powell-Chandler, A, and Underhill, R
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COMPLICATIONS ,Science & Technology ,RENAL-FAILURE ,STARSurg Collaborative ,MORTALITY ,RISK-FACTORS ,Surgery ,Life Sciences & Biomedicine - Abstract
Background Acute illness, existing co‐morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2‐week blocks over a continuous 3‐month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30‐day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30‐day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin‐converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c‐statistic 0·65). Discussion Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability.
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- 2018
14. The neutron camera upgrade for MAST Upgrade
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Cecconello, Marco, Sperduti, Andrea, Fitzgerald, I., Conroy, Sean, Holm, Stefan Jarl, Weiszflog, Matthias, Cecconello, Marco, Sperduti, Andrea, Fitzgerald, I., Conroy, Sean, Holm, Stefan Jarl, and Weiszflog, Matthias
- Abstract
The Neutron Camera Upgrade (NCU) is a neutron flux monitor consisting of six lines of sight (LoSs) under installation on Mega Ampere Spherical Tokamak (MAST) Upgrade. The NCU is expected to contribute to the study of the confinement of fast ions and on the efficiency of non-inductive current drive in the presence of on-axis and off-axis neutral beam injection by measuring the neutron emissivity profile along the equatorial plane. This paper discusses the NCU main design criteria, the engineering and interfacing issues, and the solutions adopted. In addition, the results from the characterization and performance studies of the neutron detectors using standard gamma-rays sources and a Cf-252 source are discussed. The proposed design has a time resolution of 1 ms with a statistical uncertainty of less than 10% for all MAST Upgrade scenarios with a spatial resolution of 10 cm: higher spatial resolution is possible by moving the LoSs in-between plasma discharges. The energy resolution of the neutron detector is better than 10% for a light output of 0.8 MeVee, and the measured pulse shape discrimination is satisfactory.
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- 2018
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15. Overview of recent physics results from MAST
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Andrew, Kirk, Adamek, J, Akers, Rj, Allan, S, Appel, L, F Arese Lucini, Barnes, M, Barrett, T, N Ben Ayed, Boeglin, W, Bradley, J, Browning, Pk, Brunner, J, Cahyna, P, Cardnell, S, Meghan, Carr, Casson, Federica, Marco, Cecconello, Challis, C, Chapman, It, Chapman, S, Chorley, J, Sean, Conroy, Conway, N, Cooper, Wa, Cox, M, Crocker, N, Crowley, B, Cunningham, G, Danilov, A, Darrow, D, Dendy, R, Dickinson, D, Dorland, W, Dudson, B, Dunai, D, Easy, L, Elmore, S, Evans, KAREN MARILYN, Farley, T, Fedorczak, N, Field, A, Fishpool, G, Fitzgerald, I, Fox, M, Freethy, S, Garzotti, L, Ghim, Yc, K, Gi, Gibson, K, Gorelenkova, M, Gracias, W, Gurl, C, Guttenfelder, W, Ham, C, Harrison, J, Harting, D, Havlickova, E, Hawkes, N, Hender, T, Henderson, S, Highcock, E, Hillesheim, J, Hnat, B, Horacek, J, Zehr, HOWARD JAY, Howell, D, Huang, B, Imada, K, Inomoto, M, Imazawa, R, Jones, O, Kadowaki, K, Kaye, S, Keeling, D, Iwona, Klimek, Kocan, M, Kogan, L, Komm, M, Lai, W, Leddy, J, Leggate, H, Hollocombe, J, Lipschultz, B, Lisgo, S, Liu, Yq, Lloyd, B, Lomanowski, B, Lukin, V, Lupelli, I, Maddison, G, Jens, Madsen, Mailloux, J, Martin, R, Mcardle, G, Mcclements, K, Mcmillan, B, Meakins, A, Meyer, H, Michael, C, Militello, F, Milnes, J, Morris, Aw, Motojima, G, Derek, Muir, Naylor, G, Nielsen, A, O’Brien, M, O’Gorman, T, O’Mullane, M, Olsen, J, Omotani, J, Ono, Y, Pamela, S, Pangione, L, Parra, F, Patel, A, Peebles, W, ALVAREZ PEREZ, PEDRO RICCARDO, Pinches, S, Piron, L, Price, ALEXANDER MARCUS, Reinke, M, Ricci, P, Riva, F, Roach, C, Romanelli, M, Ryan, D, Saarelma, S, Saveliev, A, Scannell, R, Schekochihin, A, Sharapov, S, Sharples, R, Shevchenko, V, Shinohara, K, Silburn, S, Simpson, J, Stanier, A, Storrs, J, Summers, H, Takase, Y, Tamain, P, Tanabe, H, Tanaka, H, Tani, K, WILLIAMSON TAYLOR, DEBIE CLAUDIA, Thomas, DEEPA ROSE, Thomas-Davies, N, and Thornton, A
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- 2017
16. The neutron camera upgrade for MAST Upgrade
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Cecconello, M., primary, Sperduti, A., additional, Fitzgerald, I., additional, Conroy, S., additional, Holm, S. J., additional, and Weiszflog, M., additional
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- 2018
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17. Overview of recent physics results from MAST
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Kirk, A., Adamek, J., Akers, R. J., Allan, S., Appel, L., Lucini, F. Arese, Barnes, M., Barrett, T., Ben Ayed, N., Boeglin, W., Bradley, J., Browning, P. K., Brunner, J., Cahyna, P., Cardnell, S., Carr, M., Casson, F., Cecconello, Marco, Challis, C., Chapman, I. T., Chapman, S., Chorley, J., Conroy, Sean, Conway, N., Cooper, W. A., Cox, M., Crocker, N., Crowley, B., Cunningham, G., Danilov, A., Darrow, D., Dendy, R., Dickinson, D., Dorland, W., Dudson, B., Dunai, D., Easy, L., Elmore, S., Evans, M., Farley, T., Fedorczak, N., Field, A., Fishpool, G., Fitzgerald, I., Fox, M., Freethy, S., Garzotti, L., Ghim, Y. C., Gi, K., Gibson, K., Gorelenkova, M., Gracias, W., Gurl, C., Guttenfelder, W., Ham, C., Harrison, J., Harting, D., Havlickova, E., Hawkes, N., Hender, T., Henderson, S., Highcock, E., Hillesheim, J., Hnat, B., Horacek, J., Howard, J., Howell, D., Huang, B., Imada, K., Inomoto, M., Imazawa, R., Jones, O., Kadowaki, K., Kaye, S., Keeling, D., Klimek, Iwona, Kocan, M., Kogan, L., Komm, M., Lai, W., Leddy, J., Leggate, H., Hollocombe, J., Lipschultz, B., Lisgo, S., Liu, Y. Q., Lloyd, B., Lomanowski, B., Lukin, V., Lupelli, I., Maddison, G., Madsen, J., Mailloux, J., Martin, R., McArdle, G., McClements, K., McMillan, B., Meakins, A., Meyer, H., Michael, C., Militello, F., Milnes, J., Morris, A. W., Motojima, G., Muir, D., Naylor, G., Nielsen, A., O'Brien, M., O'Gorman, T., O'Mullane, M., Olsen, J., Omotani, J., Ono, Y., Pamela, S., Pangione, L., Parra, F., Patel, A., Peebles, W., Perez, R., Pinches, S., Piron, L., Price, M., Reinke, M., Ricci, P., Riva, F., Roach, C., Romanelli, M., Ryan, D., Saarelma, S., Saveliev, A., Scannell, R., Schekochihin, A., Sharapov, S., Sharples, R., Shevchenko, V., Shinohara, K., Silburn, S., Simpson, J., Stanier, A., Storrs, J., Summers, H., Takase, Y., Tamain, P., Tanabe, H., Tanaka, H., Tani, K., Taylor, D., Thomas, D., Thomas-Davies, N., Thornton, A., Turnyanskiy, M., Valovic, M., Vann, R., Van Wyk, F., Walkden, N., Watanabe, T., Wilson, H., Wischmeier, M., Yamada, T., Young, J., Zoletnik, S., Kirk, A., Adamek, J., Akers, R. J., Allan, S., Appel, L., Lucini, F. Arese, Barnes, M., Barrett, T., Ben Ayed, N., Boeglin, W., Bradley, J., Browning, P. K., Brunner, J., Cahyna, P., Cardnell, S., Carr, M., Casson, F., Cecconello, Marco, Challis, C., Chapman, I. T., Chapman, S., Chorley, J., Conroy, Sean, Conway, N., Cooper, W. A., Cox, M., Crocker, N., Crowley, B., Cunningham, G., Danilov, A., Darrow, D., Dendy, R., Dickinson, D., Dorland, W., Dudson, B., Dunai, D., Easy, L., Elmore, S., Evans, M., Farley, T., Fedorczak, N., Field, A., Fishpool, G., Fitzgerald, I., Fox, M., Freethy, S., Garzotti, L., Ghim, Y. C., Gi, K., Gibson, K., Gorelenkova, M., Gracias, W., Gurl, C., Guttenfelder, W., Ham, C., Harrison, J., Harting, D., Havlickova, E., Hawkes, N., Hender, T., Henderson, S., Highcock, E., Hillesheim, J., Hnat, B., Horacek, J., Howard, J., Howell, D., Huang, B., Imada, K., Inomoto, M., Imazawa, R., Jones, O., Kadowaki, K., Kaye, S., Keeling, D., Klimek, Iwona, Kocan, M., Kogan, L., Komm, M., Lai, W., Leddy, J., Leggate, H., Hollocombe, J., Lipschultz, B., Lisgo, S., Liu, Y. Q., Lloyd, B., Lomanowski, B., Lukin, V., Lupelli, I., Maddison, G., Madsen, J., Mailloux, J., Martin, R., McArdle, G., McClements, K., McMillan, B., Meakins, A., Meyer, H., Michael, C., Militello, F., Milnes, J., Morris, A. W., Motojima, G., Muir, D., Naylor, G., Nielsen, A., O'Brien, M., O'Gorman, T., O'Mullane, M., Olsen, J., Omotani, J., Ono, Y., Pamela, S., Pangione, L., Parra, F., Patel, A., Peebles, W., Perez, R., Pinches, S., Piron, L., Price, M., Reinke, M., Ricci, P., Riva, F., Roach, C., Romanelli, M., Ryan, D., Saarelma, S., Saveliev, A., Scannell, R., Schekochihin, A., Sharapov, S., Sharples, R., Shevchenko, V., Shinohara, K., Silburn, S., Simpson, J., Stanier, A., Storrs, J., Summers, H., Takase, Y., Tamain, P., Tanabe, H., Tanaka, H., Tani, K., Taylor, D., Thomas, D., Thomas-Davies, N., Thornton, A., Turnyanskiy, M., Valovic, M., Vann, R., Van Wyk, F., Walkden, N., Watanabe, T., Wilson, H., Wischmeier, M., Yamada, T., Young, J., and Zoletnik, S.
- Abstract
New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp-up, models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge, detailed studies have revealed how filament characteristics are responsible for determining the near and far scrape off layer density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during edge localized modes (ELMs) and the number of filaments released determines the power profile at the divertor. Resonant magnetic perturbations can mitigate ELMs provided the edge peeling response is maximised and the core kink response minimised. The mitigation of intrinsic error fields with toroidal mode number n > 1 has been shown to be important for plasma performance.
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- 2017
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18. Recent progress of magnetic reconnection research in the MAST spherical tokamak
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Tanabe, H., Yamada, T., Watanabe, T., Gi, K., Inomoto, M., Imazawa, R., Gryaznevich, M., Michael, Clive, Crowley, B., Conway, N. J., Scannell, R., Harrison, J., Fitzgerald, I., Meakins, A., Hawkes, N., McClements, K. G., O'Gorman, T., Cheng, C. Z., Ono, Y., Tanabe, H., Yamada, T., Watanabe, T., Gi, K., Inomoto, M., Imazawa, R., Gryaznevich, M., Michael, Clive, Crowley, B., Conway, N. J., Scannell, R., Harrison, J., Fitzgerald, I., Meakins, A., Hawkes, N., McClements, K. G., O'Gorman, T., Cheng, C. Z., and Ono, Y.
- Abstract
In the last three years, magnetic reconnection research in the MAST spherical tokamak achieved major progress by the use of new 32 chord ion Doppler tomography and 130 channel YAG and 300 channel Ruby Thomson scattering diagnostics. In addition to the previously achieved high power plasma heating during merging, detailed full temperature profile measurements including the diffusion region have been achieved for the first time. 2D imaging measurements of ion and electron temperature profiles have revealed that magnetic reconnection mostly heats ions globally in the downstream region of outflow jet and electrons locally around the X-point. The toroidal field in MAST “over 0.3T” strongly inhibits cross-field thermal transport, and the characteristic peaked electron temperature profile around the X-point is sustained on a millisecond time scale. In contrast, ions are mostly heated in the downstream region of outflow acceleration and around the stagnation point formed by reconnected flux mostly by viscosity dissipation and shock-like compressional damping of the outflow jet. Toroidal confinement also contributes to the characteristic ion temperature profile, forming a ring structure aligned with the closed flux surface. There is an effective confinement of the downstream thermal energy due to a thick layer of reconnected flux. The characteristic structure is sustained for longer than an ion-electron energy relaxation time ( 4 ms), and the energy exchange between ions and electrons contributes to the bulk electron heating in the downstream region. The toroidal guide field mostly contributes to the formation of a localized electron heating structure around the X-point but not to bulk ion heating downstream.
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- 2017
19. Overview of recent physics results from MAST
- Author
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Kirk, A., primary, Adamek, J., additional, Akers, R.J., additional, Allan, S., additional, Appel, L., additional, Arese Lucini, F., additional, Barnes, M., additional, Barrett, T., additional, Ben Ayed, N., additional, Boeglin, W., additional, Bradley, J., additional, Browning, P.K., additional, Brunner, J., additional, Cahyna, P., additional, Cardnell, S., additional, Carr, M., additional, Casson, F., additional, Cecconello, M., additional, Challis, C., additional, Chapman, I.T., additional, Chapman, S., additional, Chorley, J., additional, Conroy, S., additional, Conway, N., additional, Cooper, W.A., additional, Cox, M., additional, Crocker, N., additional, Crowley, B., additional, Cunningham, G., additional, Danilov, A., additional, Darrow, D., additional, Dendy, R., additional, Dickinson, D., additional, Dorland, W., additional, Dudson, B., additional, Dunai, D., additional, Easy, L., additional, Elmore, S., additional, Evans, M., additional, Farley, T., additional, Fedorczak, N., additional, Field, A., additional, Fishpool, G., additional, Fitzgerald, I., additional, Fox, M., additional, Freethy, S., additional, Garzotti, L., additional, Ghim, Y.C., additional, Gi, K., additional, Gibson, K., additional, Gorelenkova, M., additional, Gracias, W., additional, Gurl, C., additional, Guttenfelder, W., additional, Ham, C., additional, Harrison, J., additional, Harting, D., additional, Havlickova, E., additional, Hawkes, N., additional, Hender, T., additional, Henderson, S., additional, Highcock, E., additional, Hillesheim, J., additional, Hnat, B., additional, Horacek, J., additional, Howard, J., additional, Howell, D., additional, Huang, B., additional, Imada, K., additional, Inomoto, M., additional, Imazawa, R., additional, Jones, O., additional, Kadowaki, K., additional, Kaye, S., additional, Keeling, D., additional, Klimek, I., additional, Kocan, M., additional, Kogan, L., additional, Komm, M., additional, Lai, W., additional, Leddy, J., additional, Leggate, H., additional, Hollocombe, J., additional, Lipschultz, B., additional, Lisgo, S., additional, Liu, Y.Q., additional, Lloyd, B., additional, Lomanowski, B., additional, Lukin, V., additional, Lupelli, I., additional, Maddison, G., additional, Madsen, J., additional, Mailloux, J., additional, Martin, R., additional, McArdle, G., additional, McClements, K., additional, McMillan, B., additional, Meakins, A., additional, Meyer, H., additional, Michael, C., additional, Militello, F., additional, Milnes, J., additional, Morris, A.W., additional, Motojima, G., additional, Muir, D., additional, Naylor, G., additional, Nielsen, A., additional, O’Brien, M., additional, O’Gorman, T., additional, O’Mullane, M., additional, Olsen, J., additional, Omotani, J., additional, Ono, Y., additional, Pamela, S., additional, Pangione, L., additional, Parra, F., additional, Patel, A., additional, Peebles, W., additional, Perez, R., additional, Pinches, S., additional, Piron, L., additional, Price, M., additional, Reinke, M., additional, Ricci, P., additional, Riva, F., additional, Roach, C., additional, Romanelli, M., additional, Ryan, D., additional, Saarelma, S., additional, Saveliev, A., additional, Scannell, R., additional, Schekochihin, A., additional, Sharapov, S., additional, Sharples, R., additional, Shevchenko, V., additional, Shinohara, K., additional, Silburn, S., additional, Simpson, J., additional, Stanier, A., additional, Storrs, J., additional, Summers, H., additional, Takase, Y., additional, Tamain, P., additional, Tanabe, H., additional, Tanaka, H., additional, Tani, K., additional, Taylor, D., additional, Thomas, D., additional, Thomas-Davies, N., additional, Thornton, A., additional, Turnyanskiy, M., additional, Valovic, M., additional, Vann, R., additional, Van Wyk, F., additional, Walkden, N., additional, Watanabe, T., additional, Wilson, H., additional, Wischmeier, M., additional, Yamada, T., additional, Young, J., additional, and Zoletnik, S., additional
- Published
- 2017
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20. The 2.5MeV neutron flux monitor for MAST
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Cecconello, M., primary, Sangaroon, S., additional, Conroy, S., additional, Donato, M., additional, Ericsson, G., additional, Marini-Bettolo, C., additional, Ronchi, R., additional, Stro¨m, P., additional, Weiszflog, M., additional, Wodniak, I., additional, Turnyanskiy, M., additional, Akers, R., additional, Cullen, A., additional, Fitzgerald, I., additional, McArdle, G., additional, Pacoto, C., additional, and Thomas-Davies, N., additional
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- 2014
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21. A neutron camera system for MAST
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Cecconello, Marco, Turnyanskiy, M., Conroy, S., Ericsson, G., Ronchi, Emanuel, Sangaroon, S., Akers, R., Fitzgerald, I., Cullen, A., Weiszflog, Matthias, Cecconello, Marco, Turnyanskiy, M., Conroy, S., Ericsson, G., Ronchi, Emanuel, Sangaroon, S., Akers, R., Fitzgerald, I., Cullen, A., and Weiszflog, Matthias
- Abstract
A prototype neutron camera has been developed and installed at MAST as part of a feasibility study for a multichord neutron camera system with the aim to measure the spatial and time resolved 2.45 MeV neutron emissivity profile. Liquid scintillators coupled to a fast digitizer are used for neutron/gamma ray digital pulse shape discrimination. The preliminary results obtained clearly show the capability of this diagnostic to measure neutron emissivity profiles with sufficient time resolution to study the effect of fast ion loss and redistribution due to magnetohydrodynamic activity. A minimum time resolution of 2 ms has been achieved with a modest 1.5 MW of neutral beam injection heating with a measured neutron count rate of a few 100 kHz.
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- 2010
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22. Bonding with self-etching primers--pumice or pre-etch? An in vitro study
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Fitzgerald, I., primary, Bradley, G. T., additional, Bosio, J. A., additional, Hefti, A. F., additional, and Berzins, D. W., additional
- Published
- 2011
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23. A neutron camera system for MAST
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Cecconello, M., primary, Turnyanskiy, M., additional, Conroy, S., additional, Ericsson, G., additional, Ronchi, E., additional, Sangaroon, S., additional, Akers, R., additional, Fitzgerald, I., additional, Cullen, A., additional, and Weiszflog, M., additional
- Published
- 2010
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24. Australian Landfall
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Charteris, A. H., primary, Kisch, Egon Erwin, additional, Fisher, J., additional, Fitzgerald, I., additional, and Fitzgerald, K., additional
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- 1939
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25. Going, going, gone...?
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Fitzgerald, I.
- Subjects
- *
BUILDINGS - Abstract
Discusses the `Buildings At Risk' survey, published by English Heritage recently, showing that almost a quarter of all listed buildings are either seriously at risk, or vulnerable to potentially irreversible states of disrepair. The survey lookedat 43,000 of the half million listed buildings in Britain; Results; Where the problem lies; Finding alternative uses for abandoned buildings; The re-use of buildings; The public response to this.
- Published
- 1992
26. Letters.
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Fitzgerald I
- Published
- 1972
27. Trends, causes and factors associated with primary Postpartum Haemorrhage (PPH) in Ireland: A review of one million hospital childbirths.
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Fitzgerald I, Corcoran P, McKernan J, Connell RO, and Greene RA
- Subjects
- Humans, Female, Ireland epidemiology, Pregnancy, Adult, Risk Factors, Incidence, Delivery, Obstetric adverse effects, Uterine Inertia epidemiology, Young Adult, Postpartum Hemorrhage epidemiology, Postpartum Hemorrhage etiology
- Abstract
Objective: To analyse temporal trends for primary Postpartum Haemorrhage (PPH), Major Obstetric Haemorrhage (MOH) between 2005 and 2021 and to examine the causes and factors contributing to the risk of PPH during 2017-2021., Methods: International ICD-10-AM diagnostic codes from hospital discharge records were used to identify cases of PPH. Temporal trends in PPH and MOH incidence were illustrated graphically. Poisson regression was used to assess the time trends and to examine factors associated with the risk of PPH during 2017-2021., Results: A total of 1,003,799 childbirth hospitalisations were recorded; 5.6% included a diagnosis of primary PPH. Risk increased almost fourfold from 2.5% in 2005 to 9.6% in 2021. The ICD-10 AM code for other immediate primary PPH was recorded for 85% of PPH cases in 2017-2021 whereas a diagnosis of uterine inertia/atony was associated with just 3.6% of the cases. Respectively, trauma-related, tissue-related and thrombin-related causes were associated with one third, 4.2% and 0.5% of cases. A wide range of factors relating to the woman including comorbidities, mode of delivery, labour-related interventions and associated traumas increased risk of PPH but placental complications, especially morbidly adherent placenta, were strong risk factors., Conclusions: Improvement in detection and anticipation of placental complications may be effective in addressing the increasing trend of PPH, however, the trends of increasing C-sections and other interventions may also need to be addressed while staff education and quality improvement projects will have a role to play., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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28. Informing the development of antipsychotic-induced weight gain management guidance: patient experiences and preferences - qualitative descriptive study.
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Fitzgerald I, Crowley EK, Ní Dhubhlaing C, O'Dwyer S, and Sahm LJ
- Abstract
Background: Antipsychotic-induced weight gain (AIWG) is a substantial contributor to high obesity rates in psychiatry. Limited management guidance exists to inform clinical practice, and individuals with experience of managing AIWG have had no or minimal input into its development. A lack of empirical research outlining patient values and preferences for management also exists. Recommendations addressing weight management in psychiatry may be distinctly susceptible to ideology and sociocultural values regarding intervention appropriateness and expectations of self-management, reinforcing the need for co-produced management guidance. This study is the first to ask: how do individuals conceptualise preferred AIWG management and how can this be realised in practice?, Aims: 1. Explore the management experiences of individuals with unwanted AIWG. 2. Elicit their values and preferences regarding preferred management., Method: Qualitative descriptive methodology informed study design. A total of 17 participants took part in semi-structured interviews. Data analysis was undertaken using reflexive thematic analysis., Results: Participants reported that clinicians largely overestimated AIWG manageability using dietary and lifestyle changes. They also reported difficulties accessing alternative management interventions, including a change in antipsychotic and/or pharmacological adjuncts. Participants reported current management guidance is oversimplified, lacks the specificity and scope required, and endorses a 'one-size-fits-all' management approach to an extensively heterogenous side-effect. Participants expressed a preference for collaborative AIWG management and guidance that prioritises early intervention using the range of evidence-based management interventions, tailored according to AIWG risk, participant ability and participant preference., Conclusion: Integration of this research into guideline development will help ensure recommendations are relevant and applicable, and that individual preferences are represented.
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- 2024
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29. Shared decision-making interventions in the choice of antipsychotic prescription in people living with psychosis (SHAPE): Protocol for a realist review.
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Fitzgerald I, Sahm LJ, Howe J, Maidment I, Wallace E, and Crowley EK
- Subjects
- Humans, Patient Participation, Choice Behavior, Antipsychotic Agents therapeutic use, Psychotic Disorders drug therapy, Psychotic Disorders psychology, Decision Making, Shared
- Abstract
Background: Shared decision-making (SDM) has yet to be successfully adopted into routine use in psychiatric settings amongst people living with severe mental illnesses. Suboptimal rates of SDM are particularly prominent amongst patients with psychotic illnesses during antipsychotic treatment choices. Many interventions have been assessed for their efficacy in improving SDM within this context, although results have been variable and inconsistent., Aims: To generate an in-depth understanding of how, why, for whom, and to what extent interventions facilitating the application of SDM during antipsychotic treatment choices work and the impact of contextual factors on intervention effectiveness., Methods: This review will use realist review methodology to provide a causal understanding of how and why interventions work when implementing SDM during antipsychotic treatment choices. The cohort of interest will be those experiencing psychosis where ongoing treatment with an antipsychotic is clinically indicated. The review will take place over five stages; (1) Locating existing theories, (2) Searching for evidence, (3) Selecting articles, (4) Extracting and organising data and (5) Synthesizing evidence and drawing conclusions. An understanding of how and why interventions work will be achieved by developing realist programme theories on intervention effectiveness through iterative literature reviews and engaging with various stakeholder groups, including patient, clinician and carer representatives., Discussion: This is the first realist review aiming to identify generative mechanisms explaining how and why successful interventions aimed at improving SDM within the parameters outlined work and in which contexts desired outcomes are most likely to be achieved. Review findings will include suggestions for clinicians, policy and decision-makers about the most promising interventions to pursue and their ideal attributes., Competing Interests: The authors declare no competing interests exist., (Copyright: © 2024 Fitzgerald et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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30. Identifying the needs of women following a severe postpartum hemorrhage.
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Fitzgerald I, McKernan J, Greene R, and O'Connell R
- Abstract
Introduction: Childbirth is a unique experience for women. In Ireland, major obstetric hemorrhage (MOH) is the most frequently reported severe maternal morbidity (SMM) with an incidence of 3.27 per 1000 maternities. Much is known now about the management of postpartum hemorrhage (PPH), and there is some research on women and their partner's experience. Less is known about how the woman feels emotionally following a PPH or what informational needs and emotional support are required. The aim of this study was to understand how women felt after experiencing a severe PPH, to listen to their first-hand experience, and to learn what improvements could be made for future care for women who experience a PPH., Methods: A descriptive, quantitative approach was conducted using semi-structured interviews with women who had a severe hemorrhage (blood loss) of ≥2.5 L between four and fourteen months postpartum., Results: Five women took part in this study. The women identified a lack of information provided to them about the reason for the significant bleeding. The women voiced they could overhear information about the event discussed between healthcare professionals but not with the woman. The care the women received in the High Dependency Unit (HDU) was significantly different from the care they received in the postnatal wards, and the women were not informed they were clinically well for transfer to the postnatal ward. It was reported that the postnatal wards were busy and short-staffed, and the women looked for more emotional support from staff, which was not available. This had an effect on their recovery in the postnatal period., Conclusions: The women reported that they wanted more information in the early postnatal period following the event, and some still had unanswered questions at the time of the interviews several months later. Most of the participants did not receive adequate emotional support from the midwives caring for them, which resulted in the participants requesting early discharge home to get emotional support from members of their family., Competing Interests: The authors have completed and submitted the ICMJE Form for disclosure of Potential Conflicts of Interest and none was reported., (© 2024 Fitzgerald I. et al.)
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- 2024
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31. Predicting antipsychotic-induced weight gain in first episode psychosis - A field-wide systematic review and meta-analysis of non-genetic prognostic factors.
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Fitzgerald I, Sahm LJ, Byrne A, O'Connell J, Ensor J, Ní Dhubhlaing C, O'Dwyer S, and Crowley EK
- Subjects
- Humans, Prognosis, Weight Gain, Body Mass Index, Antipsychotic Agents adverse effects, Psychotic Disorders drug therapy
- Abstract
Background: Whether non-genetic prognostic factors significantly influence the variable prognosis of antipsychotic-induced weight gain (AIWG) has not yet been systematically explored., Methods: Searches for both randomized and non-randomized studies were undertaken using four electronic databases, two trial registers, and via supplemental searching methods. Unadjusted and adjusted estimates were extracted. Meta-analyses were undertaken using a random-effects generic inverse model. Risk of bias and quality assessments were undertaken using Quality in Prognosis Studies (QUIPS) and Grading of Recommendations Assessment, Development and Evaluation (GRADE), respectively., Results: Seventy-two prognostic factors were assessed across 27 studies involving 4426 participants. Only age, baseline body mass index (BMI), and sex were suitable for meta-analysis. Age (b=-0.044, 95%CI -0.157-0.069), sex (b=0.236, 95%CI -0.086-0.558), and baseline BMI (b=-0.013 95%CI -0.225-0.200) were associated with nonsignificant effects on AIWG prognosis. The highest quality GRADE rating was moderate in support of age, trend of early BMI increase, antipsychotic treatment response, unemployment, and antipsychotic plasma concentration. Trend of early BMI increase was identified as the most clinically significant prognostic factor influencing long-term AIWG prognosis., Conclusions: The strong prognostic information provided by BMI trend change within 12 weeks of antipsychotic initiation should be included within AIWG management guidance to highlight those at highest risk of worse long-term prognosis. Antipsychotic switching and resource-intensive lifestyle interventions should be targeted toward this cohort. Our results challenge previous research that several clinical variables significantly influence AIWG prognosis. We provide the first mapping and statistical synthesis of studies examining non-genetic prognostic factors of AIWG and highlight practice, policy, and research implications.
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- 2023
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32. Premarital Conception as a Driver of Child Marriage and Early Union in Selected Countries in Southeast Asia and the Pacific.
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Harvey CM, FitzGerald I, Sauvarin J, Binder G, and Humphries-Waa K
- Subjects
- Adolescent, Adult, Asia, Southeastern, Child, Family, Female, Fertility, Humans, Pregnancy, Young Adult, Marriage, Pregnancy in Adolescence
- Abstract
Purpose: The aim of this study is to broaden understanding of how premarital conception in adolescence contributes to child marriage and early union in selected countries in Southeast Asia and the Pacific., Methods: Data were drawn from the latest Demographic and Health Surveys and Multiple Indicator Cluster Surveys from seven countries in Southeast Asia and Papua New Guinea, to examine patterns and trends of premarital conception and its potential contribution to early union and child marriage., Results: Among ever-married/in union women aged 20-24 years, who gave birth under 18 years, between 9% and 36% of pregnancies were conceived premaritally. Of these adolescent mothers, who conceived premaritally, 57%-92% were married by the time of birth. Data indicate a trend of increasing premarital conception in six of the selected countries., Discussion: Findings suggest that adolescent pregnancy is a significant driver of child marriage/early union in seven countries in Southeast Asia and Papua New Guinea., (Copyright © 2022 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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33. Metformin in the management of antipsychotic-induced weight gain in adults with psychosis: development of the first evidence-based guideline using GRADE methodology.
- Author
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Fitzgerald I, O'Connell J, Keating D, Hynes C, McWilliams S, and Crowley EK
- Subjects
- Adult, Humans, Weight Gain, Antipsychotic Agents adverse effects, Metformin adverse effects, Psychotic Disorders drug therapy
- Abstract
Background: Adjunctive metformin is the most well-studied intervention in the pharmacological management of antipsychotic-induced weight gain (AIWG). Although a relatively unaddressed area, among guidelines recommending consideration of metformin, prescribing information that would facilitate its applied use by clinicians, for example, provision of a dose titration schedule is absent. Moreover, recommendations differ regarding metformin's place in the hierarchy of management options. Both represent significant barriers to the applied, evidence-based use of metformin for this indication., Objective: To produce a guideline solely dedicated to the optimised use of metformin in AIWG management, using internationally endorsed guideline methodology., Methods: A list of guideline key health questions (KHQs) was produced. It was agreed that individual recommendations would be 'adopted or adapted' from current guidelines and/or developed de novo, in the case of unanswered questions. A systematic literature review (2008-2020) was undertaken to identify published guidelines and supporting (or more recent) research evidence. Quality appraisal was undertaken using the Appraisal of Guidelines Research and Evaluation II tool, A Measurement Tool to Assess Systematic Reviews (AMSTAR) assessment,and the Cochrane Risk of Bias 2 tool, where appropriate. Assessment of evidence certainty and recommendation development was undertaken using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology., Findings: We confirmed that no published guideline-of appropriate quality, solely dedicated to the use of metformin to manage AIWG was available. Recommendations located within other guidelines inadequately addressed our KHQs., Conclusion: All 11 recommendations and 7 supporting good practice developed here were formulated de novo., Clinical Implications: These recommendations build on the number and quality of recommendations in this area, and facilitate the optimised use of metformin when managing AIWG., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.)
- Published
- 2022
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34. Obesity in Adults: A 2022 Adapted Clinical Practice Guideline for Ireland.
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Breen C, O'Connell J, Geoghegan J, O'Shea D, Birney S, Tully L, Gaynor K, O'Kelly M, O'Malley G, O'Donovan C, Lyons O, Flynn M, Allen S, Arthurs N, Browne S, Byrne M, Callaghan S, Collins C, Courtney A, Crotty M, Donohue C, Donovan C, Dunlevy C, Duggan D, Fearon N, Finucane F, Fitzgerald I, Foy S, Garvey J, Gibson I, Glynn L, Gregg E, Griffin A, Harrington JM, Heary C, Heneghan H, Hogan A, Hynes M, Kearney C, Kelly D, Neff K, le Roux CW, Manning S, McAuliffe F, Moore S, Moran N, Murphy M, Murrin C, O'Brien SM, O'Donnell C, O'Dwyer S, O'Grada C, O'Malley E, O'Reilly O, O'Reilly S, Porter O, Roche HM, Rhynehart A, Ryan L, Seery S, Soare C, Shaamile F, Walsh A, Woods C, Woods C, and Yoder R
- Subjects
- Adult, Humans, Ireland, Canada, Weight Loss, Chronic Disease, Obesity therapy, Obesity psychology, Overweight therapy
- Abstract
Background: This Clinical Practice Guideline (CPG) for the management of obesity in adults in Ireland, adapted from the Canadian CPG, defines obesity as a complex chronic disease characterised by excess or dysfunctional adiposity that impairs health. The guideline reflects substantial advances in the understanding of the determinants, pathophysiology, assessment, and treatment of obesity., Summary: It shifts the focus of obesity management toward improving patient-centred health outcomes, functional outcomes, and social and economic participation, rather than weight loss alone. It gives recommendations for care that are underpinned by evidence-based principles of chronic disease management; validate patients' lived experiences; move beyond simplistic approaches of "eat less, move more" and address the root drivers of obesity., Key Messages: People living with obesity face substantial bias and stigma, which contribute to increased morbidity and mortality independent of body weight. Education is needed for all healthcare professionals in Ireland to address the gap in skills, increase knowledge of evidence-based practice, and eliminate bias and stigma in healthcare settings. We call for people living with obesity in Ireland to have access to evidence-informed care, including medical, medical nutrition therapy, physical activity and physical rehabilitation interventions, psychological interventions, pharmacotherapy, and bariatric surgery. This can be best achieved by resourcing and fully implementing the Model of Care for the Management of Adult Overweight and Obesity. To address health inequalities, we also call for the inclusion of obesity in the Structured Chronic Disease Management Programme and for pharmacotherapy reimbursement, to ensure equal access to treatment based on health-need rather than ability to pay., (© 2022 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2022
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35. Worth the Weight? Olanzapine Prescribing in Schizophrenia. A Review of Weight Gain and Other Cardiometabolic Side Effects of Olanzapine.
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Fitzgerald I, O'Dwyer S, Brooks M, Sahm L, Crowley E, and Ní Dhubhlaing C
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Published
- 2021
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36. Check the effects: systematic assessment of antipsychotic side-effects in an inpatient cohort.
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Hynes C, McWilliams S, Clarke M, Fitzgerald I, Feeney L, Taylor M, Boland F, and Keating D
- Abstract
Background: Antipsychotics are associated with a range of side-effects that can influence patients' subjective well-being negatively resulting in poor adherence. In order to limit the negative consequences of side-effects, they should be regularly systematically assessed. The aim of this study was to systematically assess antipsychotic side-effects in an inpatient cohort using validated rating scales., Methods: Eligible individuals prescribed an antipsychotic for at least 2 weeks were invited to have their side-effects assessed systematically., Results: A total of 208 individuals were assessed systematically for antipsychotic side-effects; 71.5% ( n = 138) stated that they had not reported side-effects to their clinician prior to the assessment. The most commonly reported side-effects were daytime drowsiness (75%), dry mouth (58.2%) and weight gain (50.0%), while the most distressing side-effects reported were erectile dysfunction (35.0%), sexual dysfunction (26.3%) and amenorrhoea (26.3%). There was no evidence of an association between side-effect severity/number of side-effects reported/distress caused by those taking high dose/combination antipsychotics versus standard dose monotherapy., Conclusion: Side-effects must be regularly and systematically assessed using a validated rating scale. As distress caused by side-effects plays a major role in non-adherence, assessment should examine distress and data on distressing side-effects should be available to those choosing an antipsychotic. Given the lack of correlation between high dose/combination antipsychotics and side-effects, treatment should be tailored to the individual based on response/tolerance and dose reduction/avoidance of polypharmacy should not be recommended to minimise side-effects., Competing Interests: Conflict of interest statement: Mark Taylor has received lecture or advisory fees from Janssen; Lundbeck and Otsuka. All remaining authors declare that they have no conflicting interests., (© The Author(s), 2020.)
- Published
- 2020
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37. A photostable monomeric superfolder green fluorescent protein.
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Valbuena FM, Fitzgerald I, Strack RL, Andruska N, Smith L, and Glick BS
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- Green Fluorescent Proteins genetics, Luminescent Proteins, Protein Engineering methods, Protein Folding
- Abstract
The green fluorescent protein (GFP) from Aequorea victoria has been engineered extensively in the past to generate variants suitable for protein tagging. Early efforts produced the enhanced variant EGFP and its monomeric derivative mEGFP, which have useful photophysical properties, as well as superfolder GFP, which folds efficiently under adverse conditions. We previously generated msGFP, a monomeric superfolder derivative of EGFP. Unfortunately, compared to EGFP, msGFP and other superfolder GFP variants show faster photobleaching. We now describe msGFP2, which retains monomeric superfolder properties while being as photostable as EGFP. msGFP2 contains modified N- and C-terminal peptides that are expected to reduce nonspecific interactions. Compared to EGFP and mEGFP, msGFP2 is less prone to disturbing the functions of certain partner proteins. For general-purpose protein tagging, msGFP2 may be the best available derivative of A. victoria GFP., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2020
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38. Opt-out screening for HIV, hepatitis B and hepatitis C: observational study of screening acceptance, yield and treatment outcomes.
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Grant C, O'Connell S, Lillis D, Moriarty A, Fitzgerald I, Dalby L, Bannan C, Tuite H, Crowley B, Plunkett P, Kennedy U, McMahon G, McKiernan S, Norris S, Hughes G, Shields D, and Bergin C
- Subjects
- Adult, Emergency Service, Hospital organization & administration, Female, HIV Infections diagnosis, Hepatitis B diagnosis, Hepatitis C diagnosis, Humans, Ireland, Male, Mass Screening methods, Mass Screening statistics & numerical data, Middle Aged, Choice Behavior, Diagnostic Services statistics & numerical data, Emergency Service, Hospital statistics & numerical data, Mass Screening standards
- Abstract
Background: We initiated an emergency department (ED) opt-out screening programme for HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) at our hospital in Dublin, Ireland. The objective of this study was to determine screening acceptance, yield and the impact on follow-up care., Methods: From July 2015 through June 2018, ED patients who underwent phlebotomy and could consent to testing were tested for HIV, HBV and HCV using an opt-out approach. We examined acceptance of screening, linkage to care, treatment and viral suppression using screening programme data and electronic health records. The duration of follow-up ranged from 1 to 36 months., Results: Over the 36-month study period, there were 140 550 ED patient visits, of whom 88 854 (63.2%, 95% CI 63.0% to 63.5%) underwent phlebotomy and 54 817 (61.7%, 95% CI 61.4% to 62.0%) accepted screening for HIV, HBV and HCV, representing 41 535 individual patients. 2202 of these patients had a positive test result. Of these, 267 (12.1%, 95% CI 10.8% to 13.6%) were newly diagnosed with an infection and 1762 (80.0%, 95% CI 78.3% to 81.7%) had known diagnoses. There were 38 new HIV, 47 new HBV and 182 new HCV diagnoses. 81.5% (95% CI 74.9% to 87.0%) of known patients who were not linked were relinked to care after screening. Of the new diagnoses, 86.2% (95% CI 80.4 to 90.8%) were linked to care., Conclusion: Although high proportions of patients had known diagnoses, our programme was able to identify many new infected patients and link them to care, as well as relink patients with known diagnoses who had been lost to follow-up., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2020
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39. Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers.
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FitzGerald I, Ewings P, Lang I, and Appelboam A
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- Adult, Female, Healthy Volunteers, Humans, Male, Middle Aged, Supine Position physiology, Vagus Nerve physiology, Vagus Nerve Stimulation methods, Equipment Design standards, Heart Rate physiology, Vagus Nerve Stimulation instrumentation, Valsalva Maneuver physiology
- Abstract
Background: The Valsalva manoeuvre (VM) is used to treat supraventricular tachycardia (SVT) by inducing a vagal response (drop in HR). There is debate as to the best position in which to carry out the VM and how the strain should be delivered in practice. We aimed to compare vagal responses induced with supine and modified VMs using strains delivered with a standardised manometer or novel Valsalva Assist Device (VAD), a simple device to provide resistance to exhalation., Methods: We conducted a repeated measures randomised trial of four VMs (two supine VM and two modified VMs), in healthy adult volunteers, with strains delivered using an adapted sphygmomanometer (manometer) or a VAD. Changes in HR, pressure and duration of strain and adverse events were monitored and compared between the techniques and devices. The trial was approved by the University of Exeter Medical School Research ethics committee., Results: 75 healthy participants aged 19-55 years were recruited over a 4-month period. A mixed-effects linear regression showed the modified VM resulted in a 3.8 beats per min (bpm) greater drop in HR compared with the supine VM (p=0.002, 95% CI 2.2 to 5.4). VM strains produced by the VAD were of a similar pressure but of slightly shorter duration and resulted in a 1.9 bpm smaller drop in HR compared with the manometer (p=0.01, 95% CI 0.4 to 3.4). There were no differences in adverse events., Conclusions: Modified VM was associated with a greater drop in HR than a supine VM with no increase in adverse events in healthy volunteers. The VAD can be used to safely generate the recommended VM strain pressure, but produced a smaller drop in HR compared with a manometer and requires modification to enable the recommended strain duration to be achieved consistently., Trial Registration Number: NCT03298880., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2019
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40. A Simple Device to Control Valsalva Manoeuvre Strain Pressure; a Letter to Editor.
- Author
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FitzGerald I and Appelboam A
- Abstract
Competing Interests: No Conflict of interests
- Published
- 2018
41. Opt-Out Panel Testing for HIV, Hepatitis B and Hepatitis C in an Urban Emergency Department: A Pilot Study.
- Author
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O'Connell S, Lillis D, Cotter A, O'Dea S, Tuite H, Fleming C, Crowley B, Fitzgerald I, Dalby L, Barry H, Shields D, Norris S, Plunkett PK, and Bergin C
- Subjects
- Adult, Cross-Sectional Studies, Emergency Service, Hospital, Female, HIV Antigens blood, HIV Infections epidemiology, Hepatitis B epidemiology, Hepatitis B Surface Antigens blood, Hepatitis C epidemiology, Hepatitis C Antibodies blood, Hospitals, Urban, Humans, Ireland epidemiology, Male, Middle Aged, Pilot Projects, Prevalence, Viremia diagnosis, Young Adult, HIV Infections diagnosis, Hepatitis B diagnosis, Hepatitis C diagnosis, Mass Screening methods, Viremia epidemiology
- Abstract
Objectives: Studies suggest 2 per 1000 people in Dublin are living with HIV, the level above which universal screening is advised. We aimed to assess the feasibility and acceptability of a universal opt-out HIV, Hepatitis B and Hepatitis C testing programme for Emergency Department patients and to describe the incidence and prevalence of blood-borne viruses in this population., Methods: An opt-out ED blood borne virus screening programme was piloted from March 2014 to January 2015. Patients undergoing blood sampling during routine clinical care were offered HIV 1&2 antibody/antigen assay, HBV surface antigen and HCV antibody tests. Linkage to care where necessary was co-ordinated by the study team. New diagnosis and prevalence rates were defined as the new cases per 1000 tested and number of positive tests per 1000 tested respectively., Results: Over 45 weeks of testing, of 10,000 patient visits, 8,839 individual patient samples were available for analysis following removal of duplicates. A sustained target uptake of >50% was obtained after week 3. 97(1.09%), 44(0.49%) and 447(5.05%) HIV, Hepatitis B and Hepatitis C tests were positive respectively. Of these, 7(0.08%), 20(0.22%) and 58(0.66%) were new diagnoses of HIV, Hepatitis B and Hepatitis C respectively. The new diagnosis rate for HIV, Hepatitis B and Hepatitis C was 0.8, 2.26 and 6.5 per 1000 and study prevalence for HIV, Hepatitis B and Hepatitis C was 11.0, 5.0 and 50.5 per 1000 respectively., Conclusions: Opt-out blood borne viral screening was feasible and acceptable in an inner-city ED. Blood borne viral infections were prevalent in this population and newly diagnosed cases were diagnosed and linked to care. These results suggest widespread blood borne viral testing in differing clinical locations with differing population demographic risks may be warranted.
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- 2016
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42. Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting.
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Fitzgerald I and Glick BS
- Subjects
- Green Fluorescent Proteins genetics, Protein Sorting Signals, Protein Transport, Recombinant Proteins genetics, Recombinant Proteins metabolism, Saccharomyces cerevisiae cytology, Saccharomyces cerevisiae genetics, Green Fluorescent Proteins metabolism, Saccharomyces cerevisiae metabolism, Secretory Pathway, Vacuoles metabolism
- Abstract
Background: Budding yeasts are often used to secrete foreign proteins, but the efficiency is variable. To identify roadblocks in the yeast secretory pathway, we used a monomeric superfolder GFP (msGFP) as a visual tracer in Saccharomyces cerevisiae and Pichia pastoris., Results: One roadblock for msGFP secretion is translocation into the ER. Foreign proteins are typically fused to the bipartite α-factor secretion signal, which consists of the signal sequence followed by the pro region. The α-factor signal sequence directs posttranslational translocation. For msGFP, posttranslational translocation is inefficient with the α-factor signal sequence alone but is stimulated by the pro region. This requirement for the pro region can be bypassed by using the Ost1 signal sequence, which has been shown to direct cotranslational translocation. A hybrid secretion signal consisting of the Ost1 signal sequence followed by the α-factor pro region drives efficient translocation followed by rapid ER export. A second roadblock for msGFP secretion in S. cerevisiae occurs during exit from the Golgi, when some of the msGFP molecules are diverted to the vacuole. Deletion of the sorting receptor Vps10 prevents vacuolar targeting of msGFP at the expense of missorting vacuolar hydrolases such as carboxypeptidase Y (CPY) to the culture medium. However, a truncation of Vps10 blocks vacuolar targeting of msGFP while permitting CPY to be sorted normally., Conclusions: With budding yeasts, if the secretion or processing of a foreign protein is poor, we recommend two options. First, use the Ost1 signal sequence to achieve efficient entry into the secretory pathway while avoiding the processing issues associated with the α-factor pro region. Second, truncate Vps10 to suppress diversion to the vacuole. These insights obtained with msGFP highlight the value of applying cell biological methods to study yeast secretion.
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- 2014
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43. Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.
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Cheallaigh CN, Fitzgerald I, Grace J, Singh GJ, El-Eraki N, Gibbons N, Keane J, Rogers TR, Clarke S, and Bergin C
- Subjects
- Adult, Aged, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, Female, HIV pathogenicity, HIV Infections complications, HIV Infections virology, Humans, Interferon-gamma immunology, Latent Tuberculosis complications, Latent Tuberculosis pathology, Male, Middle Aged, Prevalence, Tuberculin Test, HIV Infections pathology, Interferon-gamma metabolism, Interferon-gamma Release Tests, Latent Tuberculosis diagnosis
- Abstract
Background: Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting., Methodology/principal Findings: T-SPOT.TB, QFT-IT, and tuberculin skin tests (TST) were performed in HIV infected individuals. Results were related to patient characteristics. McNemar's test, multivariate regression and correlation analysis were carried out using SPSS (SPSS Inc). 256 HIV infected patients were enrolled in the study. The median CD4+ T-cell count was 338 cells/µL (range 1-1328). 37 (14%) patients had a CD4+ T-cell count of <100 cells/µL. 46/256 (18% ) of QFT-IT results and 28/256 (11%) of T-SPOT.TB results were positive. 6 (2%) of QFT-IT and 18 (7%) of T-SPOT.TB results were indeterminate. An additional 9 (4%) of T-SPOT.TB results were unavailable as tests were not performed due to insufficient cells or clotting of the sample. We found a statistically significant association between lower CD4+ T-cell count and negative QFT-IT results (OR 1.055, p=0.03), and indeterminate/unavailable T-SPOT.TB results (OR 1.079, p=0.02)., Conclusions/significance: In low TB prevalence settings, the QFT-IT yields more positive and fewer indeterminate results than T-SPOT.TB. Negative results on the QFT-IT and indeterminate/unavailable results on the T-SPOT.TB were more common in individuals with low CD4+ T-cell counts.
- Published
- 2013
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44. Bonding with self-etching primers--pumice or pre-etch? An in vitro study.
- Author
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Fitzgerald I, Bradley GT, Bosio JA, Hefti AF, and Berzins DW
- Subjects
- Adhesiveness, Dental Alloys chemistry, Dental Enamel ultrastructure, Dental Pellicle ultrastructure, Dental Stress Analysis instrumentation, Elastic Modulus, Humans, Light-Curing of Dental Adhesives, Materials Testing, Orthodontic Appliance Design, Orthodontic Brackets, Phosphoric Acids chemistry, Shear Strength, Stainless Steel chemistry, Stress, Mechanical, Surface Properties, Temperature, Time Factors, Water chemistry, Acid Etching, Dental methods, Dental Bonding, Dental Prophylaxis methods, Resin Cements chemistry, Silicates chemistry
- Abstract
The purpose of this study was to compare the shear bond strengths (SBSs) of orthodontic brackets bonded with self-etching primer (SEP) using different enamel surface preparations. A two-by-two factorial study design was used. Sixty human premolars were harvested, cleaned, and randomly assigned to four groups (n = 15 per group). Teeth were bathed in saliva for 48 hours to form a pellicle. Treatments were assigned as follows: group 1 was pumiced for 10 seconds and pre-etched for 5 seconds with 37 per cent phosphoric acid before bonding with SEP (Transbond Plus). Group 2 was pumiced for 10 seconds before bonding. Group 3 was pre-etched for 5 seconds before bonding. Group 4 had no mechanical or chemical preparation before bonding. All teeth were stored in distilled water for 24 hours at 37°C before debonding. The SBS values and adhesive remnant index (ARI) score were recorded. The SBS values (± 1 SD) for groups 1-4 were 22.9 ± 6.6, 16.1 ± 7.3, 36.2 ± 8.2, and 13.1 ± 10.1 MPa, respectively. Two-way analysis of variance and subsequent contrasts showed statistically significant differences among treatment groups. ARI scores indicated the majority of adhesive remained on the bracket for all four groups. Pre-etching the bonding surface for 5 seconds with 37 per cent phosphoric acid, instead of pumicing, when using SEPs to bond orthodontic brackets, resulted in greater SBSs.
- Published
- 2012
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45. Waking experience affects sleep need in Drosophila.
- Author
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Ganguly-Fitzgerald I, Donlea J, and Shaw PJ
- Subjects
- Animals, Brain Chemistry, Circadian Rhythm, Cyclic AMP metabolism, Dopamine analysis, Dopamine metabolism, Drosophila melanogaster genetics, Drosophila melanogaster growth & development, Female, Hearing, Learning, Male, Memory, Mutation, Sexual Behavior, Animal, Signal Transduction, Smell, Social Environment, Social Isolation, Vision, Ocular, Drosophila melanogaster physiology, Models, Animal, Sleep
- Abstract
Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.
- Published
- 2006
- Full Text
- View/download PDF
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