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6. Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation

Author

Saka, E., Iadarola, M., Fitzgerald, D.J., and Graybiel, A.M.

Subjects
Dopamine -- Agonists, Neurons -- Physiological aspects, Basal ganglia -- Physiological aspects, Cytochemistry -- Research, Science and technology
Abstract

Interneurons are critical for shaping neuronal circuit activity in many parts of the central nervous system. To study interneuron function in the basal ganglia, we tested and characterized an NK-1 receptor-based method for targeted ablation of specific classes of interneuron in the striatum. Our findings demonstrate that the neurotoxin SP-PE35, a substance P-Pseudomonas exotoxin conjugate, selectively targets striatal cholinergic and nitric oxide synthase/somatostatinergic interneurons when injected locally into the striatum. The effects of this selective cell targeting encompassed alterations in both behavioral and neural responses to dopaminergic stimulation, including altered patterns of early-gene response in striosomes and matrix. We conclude that NK-1-bearing local circuit neurons of the striatum regulate the differential responses of striatal projection neurons to dopamine-mediated signaling. more...

Published
2002

8. Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E (sub 2)

Author

Molloy, E.S., Morgan, M.P., Doherty, G.A., McDonnell, B., O'Byrne, J., Fitzgerald, D.J., and McCarthy, G.M.

Subjects
Calcium phosphate -- Research, Calcium phosphate -- Physiological aspects, Fibroblasts -- Research, Fibroblasts -- Physiological aspects, Prostaglandins -- Research, Prostaglandins -- Physiological aspects, Gene expression -- Research, Gene expression -- Physiological aspects, Health
Published
2008

17. MECHANISMS OF H. PYLORI INDUCED PLATELET AGGREGATION--COSIGNALLING BETWEEN PLATELET GPIb AND FcγRIIa BUT NO ROLE FOR PLATELET ACTIVATING FACTOR

Author

Byrne, M.F., Corcoran, P.A., Kerrigan, S.W., Atherton, J.C., Fitzgerald, D.J., Cox, D., and Murray, F.E.

Subjects
Research, Gastrointestinal diseases -- Research
Abstract

Human and animal data have demonstrated H.pylori induced platelet aggregation in gastric vasculature. Formation of platelet aggregates may contribute to the pathogenesis of H.pylori associated gastric injury and may also [...] more...

Published
2001

18. TRANSCRIPTIONAL REGULATION OF THE 'CONSTITUTIVE' CYCLOOXGENASE-1 GENE BY HELICOBACTER PYLORI

Author

Byrne, M.F., Corcoran, P.A., Atherton, J.G., Fitzgerald, D.J., and Murray, F.E.

Subjects
Research, Gastrointestinal diseases -- Research
Abstract

Although COX-1 is often referred to as a constitutively expressed gene, we have previously described induction of COX-1 as well as COX-2 by H. pylori suggesting that COX-1 may contribute [...]

Published
2001

25. High density oligonucleotide arrays demonstrate differential gene expression in colon cancer cells following COX-2 inhibition

Author

Byrne, S.M., Doherty, G.A., Scully, G.M., Murray, F.E., and Fitzgerald, D.J.

Subjects
Care and treatment, Research, Health aspects, COX-2 inhibitors -- Health aspects -- Research, Colorectal cancer -- Care and treatment -- Research -- Health aspects
Abstract

Aims: COX-2 plays a crucial role in colorectal carcinogenesis and selective COX-2 inhibitors have been shown to have antineoplastic effects in vitro and in vivo. The precise mechanisms underlying these [...] more...

Published
2004

35. Small RNA Regulators and the Bacterial Response to Stress

Author

GOTTESMAN, S., primary, McCULLEN, C.A., additional, GUILLIER, M., additional, VANDERPOOL, C.K., additional, MAJDALANI, N., additional, BENHAMMOU, J., additional, THOMPSON, K.M., additional, FitzGERALD, P.C., additional, SOWA, N.A., additional, and FitzGERALD, D.J., additional more...

Published
2006
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36. Differential expression of gamma-catenin (plakoglobin) in colorectal cancer following COX-2 inhibition

Author

Byrne, S.M., Doherty, G.A., Scully, G.M., Aftab, A.R., Kay, E.W., Murray, F.E., and Fitzgerald, D.J.

Subjects
Care and treatment, Research, Health aspects, COX-2 inhibitors -- Health aspects -- Research, Colorectal cancer -- Care and treatment -- Research, Cell adhesion -- Research -- Health aspects
Abstract

Aims: γ-Catenin (Plakoglobin) is a member of the catenin family. It functions in cell adhesion and the WNT signalling pathway. Defects in both WNT signalling and COX-2 expression play important [...] more...

Published
2004

44. Rap foes put 20 artists on a hit list

Author

Salem-Fitzgerald, D.J. and Philips, Chuck

Subjects
Rap music -- Laws, regulations and rules, Sound recording industry -- Laws, regulations and rules
Published
1996

47. Ore reserves at Woodlawn mine, NSW.

Author

Fitzgerald D.J., Ore reserve estimates - the impact on miners and financiers Melbourne, Australia 07-Mar-9008-Mar-90, Singer R.P., Fitzgerald D.J., Ore reserve estimates - the impact on miners and financiers Melbourne, Australia 07-Mar-9008-Mar-90, and Singer R.P. more...

Abstract

Recent ore reserve methodology at the Woodlawn base metal mine is discussed. While the overall modelling and calculation procedure remained essentially unaltered, the modifications and revised assumptions significantly increased the ore reserve. The main factors which have contributed to the increase in reserves are changed assumptions in the cut off grade criteria and in the categorisation rules., Recent ore reserve methodology at the Woodlawn base metal mine is discussed. While the overall modelling and calculation procedure remained essentially unaltered, the modifications and revised assumptions significantly increased the ore reserve. The main factors which have contributed to the increase in reserves are changed assumptions in the cut off grade criteria and in the categorisation rules. more...

Published
1990