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Desa Kare adalah salah satu desa di wilayah Kabupaten Madiun yang potensial untuk pengembangan wisata dan produk alam. Pengabdian masyarakat bertema ekowisata bertujuan (1) mengembangkan kawasan wisata berbasis partisipatif-kolaboratif, (2) meningkatkan pola kesadaran masyarakat terhadap kesehatan, (3) memberikan fasilitas kesehatan sesuai protokol kesehatan, (4) menarik minat para wisatawan melalui promosi media sosial, (5) menambah wawasan tentang cara pengolahan limbah dan produk unggulan ciri khas Desa Kare. Pelaksanaan kegiatan berlangsung dalam tiga level tahapan yaitu perencanaan kegiatan, pelaksanaan kegiatan dan tindak lanjut acara. Ekowisata dijalankan menitikberatkan pada peran aktif masyarakat setempat dan dalam kegiatan Program Pengembangan Desa Binaan (PPDB) telah dilakukan pembinaan produk dan kemasan terstandar destinasi wisata pada Unit Mikro Kecil dan Menengah (UMKM). Melalui pengmas PPDB, masyarakat setempat diberikan edukasi untuk menyiapkan masyarakat supaya sadar akan potensi alam untuk ikut menjaga dan melestarikan. Kegiatan secara berkelanjutan diharapkan untuk meningkatkan kesejahteraan serta taraf hidup masyarakat Desa Kare.

Kelelahan merupakan suatu kondisi yang dialami oleh seseorang setelah melakukan suatu pekerjaan yang berupa perasaan letih, mengantuk, bosan, dan haus. Gejala yang muncul akibat keleahan antara lain penurunan motivasi, kegiatan, dan aktivitas fisik. Salah satu cara untuk mencegah kelelahan adalah dengan mengukur kelelahan yang dialami pekerja dalam melakukan pekerjaan, selanjutnya dapat diatur kembali beban kerja agar sesuai dengan kapasitas fisik maupun mental tenaga kerja. Pelatihan pembuatan alat deteksi kelelahan ini dapat diberikan kepada siswa Sekolah Menengah Atas (SMA). Salah satunya adalah siswa dari SMA Negeri 1 Kampak Kabupaten Trenggalek. Para siswa SMA ini memerlukan peningkatan kemampuan yang dapat menjadi bekal memasuki dunia industri ataupun untuk melanjutkan studi ke jenjang yang lebih tinggi. Mereka pun masih memerlukan beberapa kemampuan yang dapat menunjang karir mereka nanti. Salah satu solusi yang bisa diberikan adah dengan memberikan pelatihan elektronika dasar dan mikrokontroler yang dapat menjadi nilai tambah bagi mereka jika akan mencari kerja ke industri. Dasar keahlian mengenai sistem komputer dan multimedia dan hasil pelatihan ini akan mnejadikan lulusan SMA ini memiliki daya saing yang lebih tinggi untuk memasuki dunia industri atau melanjutkan studi. Selain itu, kegiatan ini nantinya dapat membantu meningkatkan kemampuan entrepreneurship siswa SMA dalam membuat alat deteksi kelelahan berdasarkan respon refleks berbasis audiovisual. Wirausaha di bidang alat-alat kesehatan seperti alat deteksi kelelahan ini, dalam arti memproduksi secara mandiri dan memasarkan alat-alat kesehatan di dalam negeri masih sangat sedikit. Para siswa SMA diharapkan nantinya setelah lulus mampu mengembangkan produksi dan pengadaan alat kesehatan secara mandiri di Indonesia dalam menghadapi Masyarakat Ekonomi Asean (MEA)

Peripheral nerve injury with gaps between 5 and 30 mm can result in permanent paralysis because axons are cut. The distance between axons, which is more than 1-2 cm, needs graft in the form of nerve connecting pipe in order to repair the defects. A synthesis of hollowfiber polyurethane-collagen coated by chitosan was carried out to identify its potential as treatment accelerator for peripheral nerve injury. The result of Fourier Transform Infrared (FTIR) analysis showed multiple links between chitosan and glutaraldehyde, which can be seen in wavenumber shift from 1080-1100 cm-1 to 1002 cm-1. The degradation test result revealed that the sample displayed mass loss after it was soaked in simulated body fluid(SBF) for seven days. Polyurethanecan be degraded in the body after 30 days. This converges with the nerve mechanism that regenerates at the rate of 1 mm/day or 1 inch/month. The result of tensile test indicated that modulus values of chitosan coating variation of 1%, 1.5%, and 2% were 4.75 MPa, 4.74 MPa, and 7.67 Mpa respectively. The outcome of scanning electron microscope(SEM)showed that hollow fiberhas a diameter of 2.021-2.032 mm, which matches the diameter of peripheral nerves ranging from 1.5 to 3 mm and the membrane pore size of 31.33-39.65 μm. The result of MTT assay demonstrated that the percentage of viable fibroblastBHK-21cells was exceeding 50%, which means that the sample does not have toxic properties. The result of this study is expected to provide theoretical basis for the utilization of polyurethane-collagen coating chitosan as nervegraft for theraphy of peripheral nerve injury. The utilization is possible due to the fact that the composite exhibits biocompatible, regenerative, and easily degradable characteristics. Moreover, it could become an alternative solution to answer the need of a more affordable and easier-to-produce nerve graft, so it can be mass-produced in Indonesia.

The high number of bone fractures, around 300-400 cases per month, are treated with orthopedic surgery method using internal fixation by bone screw which is aimed at accelerating patients’ mobilization. There is a necessity to invent biomaterial which possesses two main characteristics: biocompatible and biofunctional, as well as having an important element of biodegradable without conducting reoperation. A research focused on the various composition of nano-hydroxyapatite (HA) derived from extracted snapper fish scales on Poly (1,8-octanediol-Co-Citrate (POC) as Biodegradable Bone screw. This research is purported to synthesize Poly (1,8-Octanediol-co-Citrate (POC) and characterize the influence of HA compositions against mechanical properties and compatibility of POC-HA composite that enable it to be used as Biodegradable Bone screw material. The condensation polymerization method is applied in synthesizing POC to produce POC pre-polymer by the formation of an ester bond group C=O stretch at 1731 cm-1 through a test of functional groups (FTIR). POC pre-polymer is composited with nano-HA compositions of 62%, 65%, 68% and 71% and followed by post-polymerization treatment. POC-HA composites formed were tested on hardness and biodegradability. The results obtained indicate that the composition of HA nanoparticles influences the mechanical properties and biocompatibility of the material. Best results were from 62% HA composition in which the hardness value was of 885.57 MPa, close to that of bone hardness which is 150-664 MPa. Results also showed that the rate of biodegradation reached 3.42% (4 weeks) which is in accordance to fracture bone grafting period of 21 months. Based on the characteristics result indicated in this study, the composite of Poly (1,8-Octanediol-co-Citrate) (POC)-Nano Hydroxyapatite is a potential candidate for biodegradable bone screw material.

Electrostimulation and electroactive scaffolds can positively influence and guide cellular behaviour and thus has been garnering interest as a key tissue engineering strategy. The development of conducting polymers such as polyaniline enables the fabrication of conductive polymeric composite scaffolds. In this study, we report on the initial development of a polycaprolactone scaffold incorporating different weight loadings of a polyaniline microparticle filler. The scaffolds are fabricated using screw-assisted extrusion-based 3D printing and are characterised for their morphological, mechanical, conductivity, and preliminary biological properties. The conductivity of the polycaprolactone scaffolds increases with the inclusion of polyaniline. The in vitro cytocompatibility of the scaffolds was assessed using human adipose-derived stem cells to determine cell viability and proliferation up to 21 days. A cytotoxicity threshold was reached at 1% wt. polyaniline loading. Scaffolds with 0.1% wt. polyaniline showed suitable compressive strength (6.45 &plusmn, 0.16 MPa) and conductivity (2.46 &plusmn, 0.65 &times, 10&minus, 4 S/cm) for bone tissue engineering applications and demonstrated the highest cell viability at day 1 (88%) with cytocompatibility for up to 21 days in cell culture.