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5. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., Mcfarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., and Viale, P.

Subjects
Settore MED/18 - CHIRURGIA GENERALE, Surgery, Emergency Medicine
Published
2017

6. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) (vol 11, 33, 2016)

Author

Sartelli, M., Weber, D. G., Ruppe, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, Anna Maria, Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Jusoh, A. Che, Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzman-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Junior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., Van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C., Viale, P., Universita 'La Sapienza' Roma (Istituto CNR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Universidade de Aveiro, Laboratoire matériaux et microélectronique de Provence (L2MP), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Côte d'Ivoire, Réseau International des Instituts Pasteur (RIIP), National Defence University of Malaysia [Kuala Lumpur], Max Planck Institute for the Physics of Complex Systems (MPI-PKS), Max-Planck-Gesellschaft, Center for Plant Molecular Biology, Plant Physiology, and Biophysical Chemistry, University of Tübingen, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica 'Giuseppe Occhialini' = Department of Physics 'Giuseppe Occhialini' [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Atmospheric and Environmental Research, Inc. (AER), Zhejiang University, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), and COMBE, Isabelle

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Carbapenems, Antimicrobial Resistance, Invasive Candidiasis, Methicillin Resistant Staphylococcus Aureus, Tigecycline, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance.The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria.An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2017
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7. Burden of Diarrhea in the Eastern Mediterranean Region, 1990-2013: Findings from the Global Burden of Disease Study 2013

Author

Khalil, I., Colombara, D. V., Forouzanfar, M. H., Troeger, C., Daoud, F., Moradi-Lakeh, M., Bcheraoui, C. E., Rao, P. C., Afshin, A., Charara, R., Abate, K. H., Razek, M. M. A. E., Abd-Allah, F., Abu-Elyazeed, R., Kiadaliri, A. A., Akanda, A. S., Akseer, N., Alam, K., Alasfoor, D., Ali, R., AlMazroa, M. A., Alomari, M. A., Al-Raddadi, R. M. S., Alsharif, U., Alsowaidi, S., Altirkawi, K. A., Alvis-Guzman, N., Ammar, W., Antonio, C. A. T., Asayesh, H., Asghar, R. J., Atique, S., Awasthi, A., Bacha, U., Badawi, A., Barac, A., Bedi, N., Bekele, T., Bensenor, I. M., Betsu, B. D., Bhutta, Z., Abdulhak, A. A. B., Butt, Z. A., Danawi, H., Dubey, M., Endries, A. Y., Faghmous, I. D. A., Farid, T., Farvid, M. S., Farzadfar, F., Fereshtehnejad, S.-M., Fischer, Florian, Fitchett, J. R. A., Gibney, K. B., Ginawi, I. A. M., Gishu, M. D., Gugnani, H. C., Gupta, R., Hailu, G. B., Hamadeh, R. R., Hamidi, S., Harb, H. L., Hedayati, M. T., Hsairi, M., Husseini, A., Jahanmehr, N., Javanbakht, M., Jibat, T., Jonas, J. B., Kasaeian, A., Khader, Y. S., Khan, A. R., Khan, E. A., Khan, G., Khoja, T. A. M., Kinfu, Y., Kissoon, N., Koyanagi, A., Lal, A., Latif, A. A. A., Lunevicius, R., Razek, H. M. A. E., Majeed, A., Malekzadeh, R., Mehari, A., Mekonnen, A. B., Melaku, Y. A., Memish, Z. A., Mendoza, W., Misganaw, A., Mohamed, L. A. I., Nachega, J. B., Nguyen, Q. L., Nisar, M. I., Peprah, E. K., Platts-Mills, J. A., Pourmalek, F., Qorbani, M., Rafay, A., Rahimi-Movaghar, V., Rahman, S. U., Rai, R. K., Rana, S. M., Ranabhat, C. L., Rao, S. R., Refaat, A. H., Riddle, M., Roshandel, G., Ruhago, G. M., Saleh, M. M., Sanabria, J. R., Sawhney, M., Sepanlou, S. G., Setegn, T., Sliwa, K., Sreeramareddy, C. T., Sykes, B. L., Tavakkoli, M., Tedla, B. A., Terkawi, A. S., Ukwaja, K., Uthman, O. A., Westerman, R., Wubshet, M., Yenesew, M. A., Yonemoto, N., Younis, M. Z., Zaidi, Z., Zaki, M. E. S., Rabeeah, A. A. A., Wang, H., Naghavi, M., Vos, T., Lopez, A. D., Murray, C. J. L., and Mokdad, A. H.

Subjects
Diarrhea, Male, Mediterranean Region, Bedrijfseconomie, diarrhea, eastern mediterranean region, 11 Medical And Health Sciences, Articles, Global Burden of Disease, Cost of Illness, Risk Factors, Business Economics, Tropical Medicine, Child, Preschool, Life Science, Humans, Disabled Persons, Female, Quality-Adjusted Life Years, Child
Abstract

Diarrheal diseases ( DD ) are leading causes of disease burden, death, and disability, especially in children in low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, and other sequelae. As part of the Global Burden of Disease Study, we estimated DD burden, and the burden attributable to specific risk factors and particular etiologies, in the Eastern Mediterranean Region ( EMR ) between 1990 and 2013. For both sexes and all ages, we calculated disability-adjusted life years ( DALYs ), which are the sum of years of life lost and years lived with disability. We estimate that over 125,000 deaths ( 3.6% of total deaths ) were due to DD in the EMR in 2013, with a greater burden of DD in low- and middle-income countries. Diarrhea deaths per 100,000 children under 5 years of age ranged from one ( 95% uncertainty interval [UI] = 0–1 ) in Bahrain and Oman to 471 ( 95% UI = 245–763 ) in Somalia. The pattern for diarrhea DALYs among those under 5 years of age closely followed that for diarrheal deaths. DALYs per 100,000 ranged from 739 ( 95% UI = 520–989 ) in Syria to 40,869 ( 95% UI = 21,540–65,823 ) in Somalia. Our results highlighted a highly inequitable burden of DD in EMR, mainly driven by the lack of access to proper resources such as water and sanitation. Our findings will guide preventive and treatment interventions which are based on evidence and which follow the ultimate goal of reducing the DD burden.

Published
2016

8. Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, M., primary, Weber, D. G., additional, Ruppé, E., additional, Bassetti, M., additional, Wright, B. J., additional, Ansaloni, L., additional, Catena, F., additional, Coccolini, F., additional, Abu-Zidan, F. M., additional, Coimbra, R., additional, Moore, E. E., additional, Moore, F. A., additional, Maier, R. V., additional, De Waele, J. J., additional, Kirkpatrick, A. W., additional, Griffiths, E. A., additional, Eckmann, C., additional, Brink, A. J., additional, Mazuski, J. E., additional, May, A. K., additional, Sawyer, R. G., additional, Mertz, D., additional, Montravers, P., additional, Kumar, A., additional, Roberts, J. A., additional, Vincent, J. L., additional, Watkins, R. R., additional, Lowman, W., additional, Spellberg, B., additional, Abbott, I. J., additional, Adesunkanmi, A. K., additional, Al-Dahir, S., additional, Al-Hasan, M. N., additional, Agresta, F., additional, Althani, A. A., additional, Ansari, S., additional, Ansumana, R., additional, Augustin, G., additional, Bala, M., additional, Balogh, Z. J., additional, Baraket, O., additional, Bhangu, A., additional, Beltrán, M. A., additional, Bernhard, M., additional, Biffl, W. L., additional, Boermeester, M. A., additional, Brecher, S. M., additional, Cherry-Bukowiec, J. R., additional, Buyne, O. R., additional, Cainzos, M. A., additional, Cairns, K. A, additional, Camacho-Ortiz, A., additional, Chandy, S. J., additional, Che Jusoh, A., additional, Chichom-Mefire, A., additional, Colijn, C., additional, Corcione, F., additional, Cui, Y., additional, Curcio, D., additional, Delibegovic, S., additional, Demetrashvili, Z., additional, De Simone, B., additional, Dhingra, S., additional, Diaz, J. J., additional, Di Carlo, I., additional, Dillip, A., additional, Di Saverio, S., additional, Doyle, M. P., additional, Dorj, G., additional, Dogjani, A., additional, Dupont, H., additional, Eachempati, S. R., additional, Enani, M. A., additional, Egiev, V. N., additional, Elmangory, M. M., additional, Ferrada, P., additional, Fitchett, J. R., additional, Fraga, G. P., additional, Guessennd, N., additional, Giamarellou, H., additional, Ghnnam, W., additional, Gkiokas, G., additional, Goldberg, S. R., additional, Gomes, C. A., additional, Gomi, H., additional, Guzmán-Blanco, M., additional, Haque, M., additional, Hansen, S., additional, Hecker, A., additional, Heizmann, W. R., additional, Herzog, T., additional, Hodonou, A. M., additional, Hong, S. K., additional, Kafka-Ritsch, R., additional, Kaplan, L. J., additional, Kapoor, G., additional, Karamarkovic, A., additional, Kees, M. G., additional, Kenig, J., additional, Kiguba, R., additional, Kim, P. K., additional, Kluger, Y., additional, Khokha, V., additional, Koike, K., additional, Kok, K. Y., additional, Kong, V., additional, Knox, M. C., additional, Inaba, K., additional, Isik, A., additional, Iskandar, K., additional, Ivatury, R. R., additional, Labbate, M., additional, Labricciosa, F. M., additional, Laterre, P. F., additional, Latifi, R., additional, Lee, J. G., additional, Lee, Y. R., additional, Leone, M., additional, Leppaniemi, A., additional, Li, Y., additional, Liang, S. Y., additional, Loho, T., additional, Maegele, M., additional, Malama, S., additional, Marei, H. E., additional, Martin-Loeches, I., additional, Marwah, S., additional, Massele, A., additional, McFarlane, M., additional, Melo, R. B., additional, Negoi, I., additional, Nicolau, D. P., additional, Nord, C. E., additional, Ofori-Asenso, R., additional, Omari, A. H., additional, Ordonez, C. A., additional, Ouadii, M., additional, Pereira Júnior, G. A., additional, Piazza, D., additional, Pupelis, G., additional, Rawson, T. M., additional, Rems, M., additional, Rizoli, S., additional, Rocha, C., additional, Sakakushev, B., additional, Sanchez-Garcia, M., additional, Sato, N., additional, Segovia Lohse, H. A., additional, Sganga, G., additional, Siribumrungwong, B., additional, Shelat, V. G., additional, Soreide, K., additional, Soto, R., additional, Talving, P., additional, Tilsed, J. V., additional, Timsit, J. F., additional, Trueba, G., additional, Trung, N. T., additional, Ulrych, J., additional, van Goor, H., additional, Vereczkei, A., additional, Vohra, R. S., additional, Wani, I., additional, Uhl, W., additional, Xiao, Y., additional, Yuan, K. C., additional, Zachariah, S. K., additional, Zahar, J. R., additional, Zakrison, T. L., additional, Corcione, A., additional, Melotti, R. M., additional, Viscoli, C., additional, and Viale, P., additional

Published
2017
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9. Future and potential spending on health 2015-40 : Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries

Author

Dieleman, J. L., Campbell, M., Chapin, A., Eldrenkamp, E., Fan, V. Y., Haakenstad, A., Kates, J., Li, Z., Matyasz, T., Micah, A., Reynolds, A., Sadat, N., Schneider, M. T., Sorensen, R., Abbas, K. M., Abera, S. F., Ahmad Kiadaliri, A., Ahmed, M. B., Alam, K., Alizadeh-Navaei, R., Alkerwi, A., Amini, E., Ammar, W., Antonio, C. A. T., Atey, T. M., Avila-Burgos, L., Awasthi, A., Barac, A., Berheto, T. M., Beyene, A. S., Beyene, T. J., Birungi, C., Bizuayehu, H. M., Breitborde, N. J. K., Cahuana-Hurtado, L., Castro, R. E., Catalá-López, F., Dalal, Koustuv, Dandona, L., Dharmaratne, R. D. S. D., Dubey, M., Faro, A., Feigl, A. B., Fischer, F., Fitchett, J. R. A., Foigt, N., Giref, A. Z., Gupta, R., Hamidi, S., Harb, H. L., Hay, S. I., Hendrie, D., Horino, M., JÌrisson, M., Jakovljevic, M. B., Javanbakht, M., John, D., Jonas, J. B., Karimi, S. M., Khang, Y. -H, Khubchandani, J., Kim, Y. J., Kinge, J. M., Krohn, K. J., Kumar, G. A., Leung, R., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Majeed, A., Malekzadeh, R., Malta, D. C., Meretoja, A., Miller, T. R., Mirrakhimov, E. M., Mohammed, S., Molla, G., Nangia, V., Olgiati, S., Owolabi, M. O., Patel, T., Paternina Caicedo, A. J., Pereira, D. M., Perelman, J., Polinder, S., Rafay, A., Rahimi-Movaghar, V., Rai, R. K., Ram, U., Ranabhat, C. L., Roba, H. S., Savic, M., Sepanlou, S. G., Te Ao, B. J., Tesema, A. G., Thomson, A. J., Tobe-Gai, R., Topor-Madry, R., Undurraga, E. A., Vargas, V., Vasankari, T., Violante, F. S., Wijeratne, T., Xu, G., Yonemoto, N., Younis, M. Z., Yu, C., Zaidi, Z., El Sayed Zaki, M., Murray, C. J. L., Network, Global Burden of Disease Health Financing Collaborator, Dieleman, J. L., Campbell, M., Chapin, A., Eldrenkamp, E., Fan, V. Y., Haakenstad, A., Kates, J., Li, Z., Matyasz, T., Micah, A., Reynolds, A., Sadat, N., Schneider, M. T., Sorensen, R., Abbas, K. M., Abera, S. F., Ahmad Kiadaliri, A., Ahmed, M. B., Alam, K., Alizadeh-Navaei, R., Alkerwi, A., Amini, E., Ammar, W., Antonio, C. A. T., Atey, T. M., Avila-Burgos, L., Awasthi, A., Barac, A., Berheto, T. M., Beyene, A. S., Beyene, T. J., Birungi, C., Bizuayehu, H. M., Breitborde, N. J. K., Cahuana-Hurtado, L., Castro, R. E., Catalá-López, F., Dalal, Koustuv, Dandona, L., Dharmaratne, R. D. S. D., Dubey, M., Faro, A., Feigl, A. B., Fischer, F., Fitchett, J. R. A., Foigt, N., Giref, A. Z., Gupta, R., Hamidi, S., Harb, H. L., Hay, S. I., Hendrie, D., Horino, M., JÌrisson, M., Jakovljevic, M. B., Javanbakht, M., John, D., Jonas, J. B., Karimi, S. M., Khang, Y. -H, Khubchandani, J., Kim, Y. J., Kinge, J. M., Krohn, K. J., Kumar, G. A., Leung, R., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Majeed, A., Malekzadeh, R., Malta, D. C., Meretoja, A., Miller, T. R., Mirrakhimov, E. M., Mohammed, S., Molla, G., Nangia, V., Olgiati, S., Owolabi, M. O., Patel, T., Paternina Caicedo, A. J., Pereira, D. M., Perelman, J., Polinder, S., Rafay, A., Rahimi-Movaghar, V., Rai, R. K., Ram, U., Ranabhat, C. L., Roba, H. S., Savic, M., Sepanlou, S. G., Te Ao, B. J., Tesema, A. G., Thomson, A. J., Tobe-Gai, R., Topor-Madry, R., Undurraga, E. A., Vargas, V., Vasankari, T., Violante, F. S., Wijeratne, T., Xu, G., Yonemoto, N., Younis, M. Z., Yu, C., Zaidi, Z., El Sayed Zaki, M., Murray, C. J. L., and Network, Global Burden of Disease Health Financing Collaborator

Abstract

Background: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending. Methods: We extracted GDP, government spending in 184 countries from 1980-2015, and health spend data from 1995-2014. We used a series of ensemble models to estimate future GDP, all-sector government spending, development assistance for health, and government, out-of-pocket, and prepaid private health spending through 2040. We used frontier analyses to identify patterns exhibited by the countries that dedicate the most funding to health, and used these frontiers to estimate potential health spending for each low-income or middle-income country. All estimates are inflation and purchasing power adjusted. Findings: We estimated that global spending on health will increase from US$9.21 trillion in 2014 to $24.24 trillion (uncertainty interval [UI] 20.47-29.72) in 2040. We expect per capita health spending to increase fastest in upper-middle-income countries, at 5.3% (UI 4.1-6.8) per year. This growth is driven by continued growth in GDP, government spending, and government health spending. Lower-middle income countries are expected to grow at 4.2% (3.8-4.9). High-income countries are expected to grow at 2.1% (UI 1.8-2.4) and low-income countries are expected to grow at 1.8% (1.0-2.8). Despite this growth, health spending per capita in low-income countries is expected to remain low, at $154 (UI 133-181) per capita in 2030 and $195 (157-258) per capita in 2040. Increases in national hea

Published
2017
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10. Evolution and patterns of global health financing 1995-2014 : Development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries

Author

Dieleman, J., Campbell, M., Chapin, A., Eldrenkamp, E., Fan, V. Y., Haakenstad, A., Kates, J., Liu, Y., Matyasz, T., Micah, A., Reynolds, A., Sadat, N., Schneider, M. T., Sorensen, R., Evans, T., Evans, D., Kurowski, C., Tandon, A., Abbas, K. M., Abera, S. F., Ahmad Kiadaliri, A., Ahmed, K. Y., Ahmed, M. B., Alam, K., Alizadeh-Navaei, R., Alkerwi, A., Amini, E., Ammar, W., Amrock, S. M., Antonio, C. A. T., Atey, T. M., Avila-Burgos, L., Awasthi, A., Barac, A., Bernal, O. A., Beyene, A. S., Beyene, T. J., Birungi, C., Bizuayehu, H. M., Breitborde, N. J. K., Cahuana-Hurtado, L., Castro, R. E., Catalá-López, F., Dalal, Koustuv, Dandona, L., Dandona, R., De Jager, P., Dharmaratne, S. D., Dubey, M., Farinha, C. S. E. S., Faro, A., Feigl, A. B., Fischer, F., Fitchett, J. R. A., Foigt, N., Giref, A. Z., Gupta, R., Hamidi, S., Harb, H. L., Hay, S. I., Hendrie, D., Horino, M., JÌrisson, M., Jakovljevic, M. B., Javanbakht, M., John, D., Jonas, J. B., Karimi, S. M., Khang, Y. -H, Khubchandani, J., Kim, Y. J., Kinge, J. M., Krohn, K. J., Kumar, G. A., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Majeed, A., Malekzadeh, R., Masiye, F., Meier, T., Meretoja, A., Miller, T. R., Mirrakhimov, E. M., Mohammed, S., Nangia, V., Olgiati, S., Osman, A. S., Owolabi, M. O., Patel, T., Paternina Caicedo, A. J., Pereira, D. M., Perelman, J., Polinder, S., Rafay, A., Rahimi-Movaghar, V., Rai, R. K., Ram, U., Ranabhat, C. L., Roba, H. S., Salama, J., Savic, M., Sepanlou, S. G., Shrime, M. G., Talongwa, R. T., Te Ao, B. J., Tediosi, F., Tesema, A. G., Thomson, A. J., Tobe-Gai, R., Topor-Madry, R., Undurraga, E. A., Vasankari, T., Violante, F. S., Werdecker, A., Wijeratne, T., Xu, G., Yonemoto, N., Younis, M. Z., Yu, C., Zaidi, Z., El Sayed Zaki, M., Murray, C. J. L., Network, Global Burden of Disease Health Financing Collaborator, Dieleman, J., Campbell, M., Chapin, A., Eldrenkamp, E., Fan, V. Y., Haakenstad, A., Kates, J., Liu, Y., Matyasz, T., Micah, A., Reynolds, A., Sadat, N., Schneider, M. T., Sorensen, R., Evans, T., Evans, D., Kurowski, C., Tandon, A., Abbas, K. M., Abera, S. F., Ahmad Kiadaliri, A., Ahmed, K. Y., Ahmed, M. B., Alam, K., Alizadeh-Navaei, R., Alkerwi, A., Amini, E., Ammar, W., Amrock, S. M., Antonio, C. A. T., Atey, T. M., Avila-Burgos, L., Awasthi, A., Barac, A., Bernal, O. A., Beyene, A. S., Beyene, T. J., Birungi, C., Bizuayehu, H. M., Breitborde, N. J. K., Cahuana-Hurtado, L., Castro, R. E., Catalá-López, F., Dalal, Koustuv, Dandona, L., Dandona, R., De Jager, P., Dharmaratne, S. D., Dubey, M., Farinha, C. S. E. S., Faro, A., Feigl, A. B., Fischer, F., Fitchett, J. R. A., Foigt, N., Giref, A. Z., Gupta, R., Hamidi, S., Harb, H. L., Hay, S. I., Hendrie, D., Horino, M., JÌrisson, M., Jakovljevic, M. B., Javanbakht, M., John, D., Jonas, J. B., Karimi, S. M., Khang, Y. -H, Khubchandani, J., Kim, Y. J., Kinge, J. M., Krohn, K. J., Kumar, G. A., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Majeed, A., Malekzadeh, R., Masiye, F., Meier, T., Meretoja, A., Miller, T. R., Mirrakhimov, E. M., Mohammed, S., Nangia, V., Olgiati, S., Osman, A. S., Owolabi, M. O., Patel, T., Paternina Caicedo, A. J., Pereira, D. M., Perelman, J., Polinder, S., Rafay, A., Rahimi-Movaghar, V., Rai, R. K., Ram, U., Ranabhat, C. L., Roba, H. S., Salama, J., Savic, M., Sepanlou, S. G., Shrime, M. G., Talongwa, R. T., Te Ao, B. J., Tediosi, F., Tesema, A. G., Thomson, A. J., Tobe-Gai, R., Topor-Madry, R., Undurraga, E. A., Vasankari, T., Violante, F. S., Werdecker, A., Wijeratne, T., Xu, G., Yonemoto, N., Younis, M. Z., Yu, C., Zaidi, Z., El Sayed Zaki, M., Murray, C. J. L., and Network, Global Burden of Disease Health Financing Collaborator

Abstract

Background: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development. We also identify countries that deviate from the trends. Methods: We estimated national health spending by type of care and by source, including development assistance for health, based on a diverse set of data including programme reports, budget data, national estimates, and 964 National Health Accounts. These data represent health spending for 184 countries from 1995 through 2014. We converted these data into a common inflation-adjusted and purchasing power-adjusted currency, and used non-linear regression methods to model the relationship between health financing, time, and economic development. Findings: Between 1995 and 2014, economic development was positively associated with total health spending and a shift away from a reliance on development assistance and out-of-pocket (OOP) towards government spending. The largest absolute increase in spending was in high-income countries, which increased to purchasing power-adjusted $5221 per capita based on an annual growth rate of 3.0%. The largest health spending growth rates were in upper-middle-income (5.9) and lower-middle-income groups (5.0), which both increased spending at more than 5% per year, and spent $914 and $267 per capita in 2014, respectively. Spending in low-income countries grew nearly as fast, at 4.6%, and health spending increased from $51 to $120 per capita. In 2014, 59.2% of all health spending was financed by the government, although in low-income and lower-middle-income countries, 29.1% and 58.0%

Published
2017
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14. Funding healthcare-associated infection research: a systematic analysis of UK research investments, 1997-2010.

Author

Head, M G, Fitchett, J R, Holmes, A H, and Atun, R

Abstract

Background: Healthcare-associated infections (HCAIs) are a cause of high health and economic burden in the UK. The number of HCAI research studies funded in the UK, and the associated amount of investment, has not previously been analysed.Aim: To assess the level of research funding awarded to UK institutions for HCAI research and the relationship of funded research to clinical and public health burden of HCAIs.Methods: Databases and websites were systematically searched for information on how infectious disease research studies were funded for the period 1997-2010. Studies specifically related to HCAI research were identified and categorized in terms of funding by pathogen, disease, and by a research and development value chain describing the type of science.Findings: The overall dataset included 6165 studies (total investment £2.6 billion) of which £57.7 million was clearly directed towards HCAI research across 297 studies (2.2% of total spend, 2.1% of total studies). Of the HCAI-related projects, 45 studies had a specific focus on MRSA (£10.3 million), 14 towards Clostridium difficile (£10.7 million), two towards pneumonia (£0.3 million) and 103 studies related to surgical infections (£14.1 million). Mean and median study funding was £194,129 (standard deviation: £429,723) and £52,684 (interquartile range: £9,168 to £201,658) respectively. Award size ranged from £108 to £50.0 million.Conclusions: Research investment for HCAIs has gradually increased in the study period, but remains low due to the health, economic, and social burden of HCAI. Research for hospital-acquired pneumonia, behavioural interventions, economic analyses, and research on emerging pathogens exhibiting antimicrobial resistance remain underfunded. [ABSTRACT FROM AUTHOR]

Published
2014
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15. Pharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomes.

Author

Yu RZ, Geary RS, Leeds JM, Watanabe T, Fitchett JR, Matson JE, Mehta R, Hardee GR, Templin MV, Huang K, Newman MS, Quinn Y, Uster P, Zhu G, Working PK, Horner M, Nelson J, and Levin AA

Subjects
Animals, Blood Proteins metabolism, Capsules pharmacokinetics, Drug Delivery Systems, Female, Gene Expression Regulation drug effects, Half-Life, Kinetics, Liposomes, Macaca mulatta, Male, Metabolic Clearance Rate, Oligonucleotides, Antisense administration & dosage, Oligonucleotides, Antisense chemical synthesis, Oligonucleotides, Antisense pharmacology, Phosphorothioate Oligonucleotides, Tissue Distribution, ras Proteins genetics, Oligonucleotides, Antisense pharmacokinetics, ras Proteins antagonists & inhibitors
Abstract

Purpose: This study examined the pharmacokinetics and tissue distribution of an antisense oligonucleotide ISIS 2503, formulated in stealth (pegylated) liposomes (encapsulated) or in phosphate-buffered saline (unencapsulated)., Methods: Encapsulated or unencapsulated ISIS 2503 was administered to rhesus monkeys by intravenous infusion. The concentrations of ISIS 2503 and metabolites in blood, plasma, and tissue samples were determined by capillary gel electrophoresis., Results: Plasma concentrations of encapsulated ISIS 2503 decreased mono-exponentially after infusion with a mean half-life of 57.8 hours. In contrast, the concentration of unencapsulated ISIS 2503 in plasma decreased rapidly with a mean half-life of 1.07 hours. Both encapsulated and unencapsulated ISIS 2503 distributed widely into tissues. Encapsulated ISIS 2503 distributed primarily to the reticulo-endothelial system and there were few metabolites observed. In contrast, unencapsulated ISIS 2503 distributed rapidly to tissue with highest concentration seen in kidney and liver. Nuclease-mediated metabolism was extensive for unencapsulated oligonucleotide in plasma and tissues., Conclusions: The data suggest that stealth liposomes protect ISIS 2503 from nucleases in blood and tissues, slow tissue uptake, and slow the rate of clearance from the systemic circulation. These attributes may make these formulations attractive for delivering oligonucleotides to sites with increased vasculature permeability such as tumors or sites of inflammation.

Published
1999
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