1. Distribution and determinants of serum high-sensitivity C-reactive protein in Ethiopian population
- Author
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Solomon Tebeje, Fisume Girma, Daniel Seifu, Ebba Abate, Abebe Bekele, Zeleke Geto, Mistire Wolde, Meron Sileshi, Theodros Getachew, Bikila Nagasa, Habtamu Teklie, Terefe Gelibo, Feyissa Challa, Atkure Defar, Anna Carobene, Tigist Getahun, and Solomon Teferra
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Clinical Biochemistry ,Population ,Black People ,Disease ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Internal medicine ,Inflammatory marker ,medicine ,Distribution (pharmacology) ,Humans ,cardiovascular diseases ,education ,Volume concentration ,education.field_of_study ,biology ,business.industry ,Cut off value ,Biochemistry (medical) ,C-reactive protein ,nutritional and metabolic diseases ,General Medicine ,030104 developmental biology ,C-Reactive Protein ,Cross-Sectional Studies ,030220 oncology & carcinogenesis ,biology.protein ,Female ,business ,Biomarkers - Abstract
Background C-reactive protein (CRP) is an important inflammatory marker associated with different disease conditions, and its concentration differs among ethnicity. This study aimed to determine the distribution and determinants of serum high-sensitive method CRP (hsCRP) that can measure the typically low concentrations, among the Ethiopian population, for which there is no data. Methods A cross-sectional community-based study was conducted in April-June 2015. A total of 5162 individuals aged 15–69 were included. Behavioral, physical, and biochemical measurements were taken using the WHO STEPS non-communicable diseases (NCDs) risk factors assessment tool. Serum hsCRP was determined using Cobas Integra 400 Plus (Roche). Factors associated with hsCRP levels were also considered. Results median hsCRP was 0.80 mg/L (Interquartile range, 0.19–2.12) (males: 0.91 mg/L, females: 0.74 mg/L). More than 18% of the study participants had hsCRP greater than 3 mg/L according to the American Heart Association and Centers for Diseases Control and Preventions cut off value. Higher BMI, living in Somali and in Dire Dawa region, and not consuming of fruit or vegetables were independent risk factors for high hsCRP levels. Conclusion Serum hsCRP levels distribution is comparable to other studies. Until now, no data have been reported in the literature about the Ethiopian population.
- Published
- 2020