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3. Nuclear Limits on Non-Minimally Coupled Gravity

Author

Fisher, Sarah B. and Carlson, Eric D.

Subjects
General Relativity and Quantum Cosmology
Abstract

We explore alternate theories of gravity where the gravitational term in the Lagrangian $\frac{R}{8\pi G}$ is replaced by a function $f_1(R)$ and the matter Lagrangian is multiplied by a function $f_2(R)$. We argue that nuclear physics can provide strong experimental constraints on such theories. In particular using energy conditions on the pressure in the $^4$He nucleus, for $f_1(R)=\frac{R}{8\pi G}$ and $f_2(R)=1+\lambda R$, we find a limit of $|\lambda| < 5\times 10^{-12}\, \hbox{m}^2$, more than thirty orders of magnitude stronger than the previous limit., Comment: 2 figures

Published
2021
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7. Response to Comment on 'Reexamining $f(R,T)$ Gravity'

Author

Fisher, Sarah B. and Carlson, Eric D.

Subjects
General Relativity and Quantum Cosmology
Abstract

Harko and Moraes claim that in $f(R,T)$ gravity with $f(R,T)=f_1(R)+f_2(T)$, the term $f_2(T)$ cannot be incorporated in the matter Lagrangian ${\cal L}_m$. A careful examination of their Comment finds that they have made several dubious assumptions without indicating any errors in our work. Most notably, they have unjustifiably claimed that the two terms ${\cal L}_m$ and $f_2(T)$ are of ``different origin,'' and their inference that only the first contributes to the energy momentum tensor is arbitrary. Also significant, their derivation of equations of motion from a Lagrangian formulation, imposing conservation constraints {\it ad hoc} rather than via Lagrange multipliers, leads to inconsistent conclusions.

Published
2020
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9. Reexamining $f(R,T)$ gravity

Author

Fisher, Sarah B. and Carlson, Eric D.

Subjects
General Relativity and Quantum Cosmology
Abstract

We study $f(R,T)$ gravity, in which the curvature $R$ appearing in the gravitational Lagrangian is replaced by an arbitrary function of the curvature and the trace $T$ of the stress-energy tensor. We focus primarily on situations where $f$ is separable, so that $f(R,T) = f_1(R) + f_2(T)$. We argue that the term $f_2(T)$ should be included in the matter Lagrangian ${\cal L}_m$, and therefore has no physical significance. We demonstrate explicitly how this can be done for the cases of free fields and for perfect fluids. We argue that all uses of $f_2(T)$ for cosmological modeling and all attempts to place limits on parameters describing $f_2(T)$ are misguided.

Published
2019
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10. Neoadjuvant relatlimab and nivolumab in resectable melanoma

Author

Amaria, Rodabe N., Postow, Michael, Burton, Elizabeth M., Tezlaff, Michael T., Ross, Merrick I., Torres-Cabala, Carlos, Glitza, Isabella C., Duan, Fei, Milton, Denái R., Busam, Klaus, Simpson, Lauren, McQuade, Jennifer L., Wong, Michael K., Gershenwald, Jeffrey E., Lee, Jeffrey E., Goepfert, Ryan P., Keung, Emily Z., Fisher, Sarah B., Betof-Warner, Allison, Shoushtari, Alexander N., Callahan, Margaret, Coit, Daniel, Bartlett, Edmund K., Bello, Danielle, Momtaz, Parisa, Nicholas, Courtney, Gu, Aidi, Zhang, Xuejun, Korivi, Brinda Rao, Patnana, Madhavi, Patel, Sapna P., Diab, Adi, Lucci, Anthony, Prieto, Victor G., Davies, Michael A., Allison, James P., Sharma, Padmanee, Wargo, Jennifer A., Ariyan, Charlotte, and Tawbi, Hussein A.

Published
2022
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19. Author Correction: Neoadjuvant relatlimab and nivolumab in resectable melanoma

Author

Amaria, Rodabe N., Postow, Michael, Burton, Elizabeth M., Tetzlaff, Michael T., Ross, Merrick I., Torres-Cabala, Carlos, Glitza, Isabella C., Duan, Fei, Milton, Denái R., Busam, Klaus, Simpson, Lauren, McQuade, Jennifer L., Wong, Michael K., Gershenwald, Jeffrey E., Lee, Jeffrey E., Goepfert, Ryan P., Keung, Emily Z., Fisher, Sarah B., Betof-Warner, Allison, Shoushtari, Alexander N., Callahan, Margaret, Coit, Daniel, Bartlett, Edmund K., Bello, Danielle, Momtaz, Parisa, Nicholas, Courtney, Gu, Aidi, Zhang, Xuejun, Korivi, Brinda Rao, Patnana, Madhavi, Patel, Sapna P., Diab, Adi, Lucci, Anthony, Prieto, Victor G., Davies, Michael A., Allison, James P., Sharma, Padmanee, Wargo, Jennifer A., Ariyan, Charlotte, and Tawbi, Hussein A.

Published
2023
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22. Beyond the three P's: adrenal involvement in MEN1

Author

MS Endocriene Oncologie, Cancer, Clemente-Gutierrez, Uriel, Pieterman, Carolina R.C., Lui, Michael S., Yamashita, Thomas Szabo, Tame-Elorduy, Andrés, Huang, Bernice L., Shirali, Aditya S., Erstad, Derek J., Lee, Jeffrey E., Fisher, Sarah B., Graham, Paul H., Grubbs, Elizabeth G., Waguespack, Steven G., Ng, Chaan S., Perrier, Nancy, MS Endocriene Oncologie, Cancer, Clemente-Gutierrez, Uriel, Pieterman, Carolina R.C., Lui, Michael S., Yamashita, Thomas Szabo, Tame-Elorduy, Andrés, Huang, Bernice L., Shirali, Aditya S., Erstad, Derek J., Lee, Jeffrey E., Fisher, Sarah B., Graham, Paul H., Grubbs, Elizabeth G., Waguespack, Steven G., Ng, Chaan S., and Perrier, Nancy

Published
2024

24. Next-Generation Sequencing in Sporadic Medullary Thyroid Cancer Patients: Mutation Profile and Disease Aggressiveness.

Author

Shirali, Aditya S, Hu, Mimi I, Chiang, Yi-Ju, Graham, Paul H, Fisher, Sarah B, Sosa, Julie Ann, Perrier, Nancy, Brown, Spandana, Holla, Vijaykumar R, Dadu, Ramona, Busaidy, Naifa, Sherman, Steven I, Cabanillas, Maria, Waguespack, Steven G, Zafereo, Mark E, and Grubbs, Elizabeth G

Subjects
NUCLEOTIDE sequencing, SOMATIC mutation, MEDULLARY thyroid carcinoma, CANCER patients, OVERALL survival
Abstract

Context Next-generation sequencing (NGS) analysis of sporadic medullary thyroid carcinoma (sMTC) has led to increased detection of somatic mutations, including RET M918T, which has been considered a negative prognostic indicator. Objective This study aimed to determine the association between clinicopathologic behavior and somatic mutation identified on clinically motivated NGS. Methods In this retrospective cohort study, patients with sMTC who underwent NGS to identify somatic mutations for treatment planning were identified. Clinicopathologic factors, time to distant metastatic disease (DMD), disease-specific survival (DSS), and overall survival (OS) were compared between somatic mutations. Results Somatic mutations were identified in 191 sMTC tumors, including RET M918T (53.4%), other RET codons (10.5%), RAS (18.3%), somatic RET indels (8.9%), and RET/RAS wild-type (WT) status (8.9%). The median age at diagnosis was 50 years (range, 11-83); 46.1% were female. When comparing patients with RET M918T, RET- Other, and RET WT (which included RAS and RET/RAS WT), there were no differences in sex, TNM category, systemic therapy use, time to DMD, DSS, or OS. On multivariate analysis, older age at diagnosis (HR 1.05, P <.001; HR 1.06, P <.001) and M1 stage at diagnosis (HR 3.17, P =.001; HR 2.98, P =.001) were associated with decreased DSS and OS, respectively, but mutation cohort was not. When comparing RET M918T to RET indels there was no significant difference in time to DMD, DSS, or OS between the groups. Conclusion Somatic RET mutations do not portend compromised DSS or OS in a cohort of sMTC patients who underwent clinically motivated NGS. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Decreasing utilization for postoperative radiation therapy in locoregionally advanced medullary thyroid cancer

Author

Maniakas, Anastasios, primary, Sullivan, Andrew, additional, Hu, Mimi I., additional, Busaidy, Naifa L., additional, Cabanillas, Maria E., additional, Dadu, Ramona, additional, Waguespack, Steven G., additional, Fisher, Sarah B., additional, Graham, Paul H., additional, Gross, Neil D., additional, Grubbs, Elizabeth G., additional, Perrier, Nancy D., additional, Wang, Jennifer R., additional, Gunn, Brandon, additional, Garden, Adam S., additional, Megahed, Romy, additional, Navuluri, Sriram, additional, Li, Xu, additional, Williams, Michelle D., additional, and Zafereo, Mark, additional

Published
2023
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30. Is there a role for liquid biopsy in the surveillance of parathyroid carcinoma?

Author

Szabo Yamashita, Thomas, primary, Shirali, Aditya S., additional, Meas, Salyna, additional, Sarli, Vanessa, additional, Clemente-Gutierrez, Uriel E., additional, Chiang, Yi-Ju, additional, Silva-Figueroa, Angelica, additional, Vodopivec, Danica M., additional, Williams, Michelle, additional, Fisher, Sarah B., additional, Graham, Paul H., additional, Grubbs, Elizabeth G., additional, Lucci, Anthony, additional, Busaidy, Naifa, additional, and Perrier, Nancy D., additional

Published
2023
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31. Incidence and geographical distribution of adrenocortical carcinoma: Retrospective analysis of a state cancer registry

Author

Balderrama-Brondani, Vania, primary, Griffin, Allison M., additional, Owen, Taylor J., additional, Merriman, Kelly W., additional, Chahla, Brenda B., additional, Varghese, Jeena, additional, Jimenez, Camilo, additional, Waguespack, Steven G., additional, Graham, Paul H., additional, Perrier, Nancy D., additional, Fisher, Sarah B., additional, Karam, Jose A., additional, Shah, Amishi Y., additional, Campbell, Matthew, additional, Hassan, Manal M., additional, and Habra, Mouhammed Amir, additional

Published
2023
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32. List of Contributors

Author

Asare, Elliot A., primary, Bai, Harrison X., additional, Bancos, Irina, additional, Bauer, Andrew J., additional, Carmela, De Crea, additional, Chen, Yufei, additional, Delivanis, Danae, additional, Dralle, Henning, additional, Duh, Quan-Yang, additional, Fahey, Thomas J., additional, Fernandez Ranvier, Gustavo G., additional, Finnerty, Brendan M., additional, Fisher, Sarah B., additional, Francesco, Pennestrì, additional, Habra, Mouhammed Amir, additional, Hallman, Joan, additional, Halsey, Jordan N., additional, Hamidi, Oksana, additional, Inabnet, William B., additional, Ito, Yasuhiro, additional, Kebebew, Electron, additional, Krasnova, Svetlana L., additional, Kruijff, Schelto, additional, Laird, Amanda M., additional, Lee, James A., additional, Libutti, Steven K., additional, Lou, Irene, additional, Machens, Andreas, additional, Maggio, William W., additional, Marcadis, Andrea R., additional, Raffaelli, Marco, additional, Mazeh, Haggi, additional, McCartney-Anderson, Maureen, additional, Mekel, Michal, additional, Meknat, Aryan, additional, Miyauchi, Akira, additional, Nobecourt, Priscilla, additional, Patel, Tushar R., additional, Pearlstein, Sarah S., additional, Perrier, Nancy D., additional, Pio, Lombardi Celestino, additional, Rocco, Bellantone, additional, Schmid, Kurt Werner, additional, Shah, Meera, additional, Shaha, Ashok R., additional, Shargorodsky, Josef, additional, Sharma, Anu, additional, Shifrin, Alexander L., additional, Silva-Figueroa, Angelica M., additional, Sinclair, Tiffany J., additional, Stratakis, Constantine A., additional, Suzuki, Mari, additional, Trerotola, Scott O., additional, van der Plas, Willemijn Y., additional, Vogt, Liffert, additional, and Yalon, Tal, additional

Published
2020
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35. Beyond the three P's: adrenal involvement in MEN.

Author

Clemente-Gutierrez, Uriel, Pieterman, Carolina R. C., Lui, Michael S., Yamashita, Thomas Szabo, Tame-Elorduy, Andrés, Huang, Bernice L., Shirali, Aditya S., Erstad, Derek J., Lee, Jeffrey E., Fisher, Sarah B., Graham, Paul H., Grubbs, Elizabeth G., Waguespack, Steven G., Ng, Chaan S., and Perrier, Nancy

Subjects
WATCHFUL waiting, ADRENAL tumors, DISEASE progression, HYPERALDOSTERONISM, CUSHING'S syndrome, PHEOCHROMOCYTOMA
Abstract

Adrenal lesions (ALs) are often detected in patients with multiple endocrine neoplasia type 1 (MEN1). However, they are not well described in MEN1, making their clinical management unclear. This study examined the prevalence and outcomes of ALs found in MEN1. We performed a retrospective chart review of patients diagnosed with MEN1 from 1990 to 2021. ALs were diagnosed using abdominal or thoracic imaging and classified as being unilateral or bilateral, having single or multiple nodules, and as having diffuse enlargement or not. Measurable nodular lesions were analyzed for their size and growth over time. Patients' clinical and radiographic characteristics were collected. We identified 382 patients with MEN1, 89 (23.3%) of whom had ALs. The mean age at detection was 47 ± 11.9 years. We documented 101 measurable nodular lesions (mean size, 17.5 mm; range, 3-123 mm). Twenty-seven nodules (26.7%) were smaller than 1 cm. Watchful waiting was indicated in 79 (78.2%) patients, of whom 28 (35.4%) had growing lesions. Functional lesions were diagnosed in 6 (15.8%) of 38 that had functional work-up (diagnoses: pheochromocytoma (n = 2), adrenocorticotropic hormone-dependent hypercortisolism (n = 2), hyperandrogenism (n = 1), hyperaldosteronism (n = 1)); surgery was indicated for 5 (83.3%; n = 12 nodules), 2 of whom had bilateral, diffuse adrenal enlargement. Two patients were diagnosed with adrenocortical carcinoma and two with neoplasms of uncertain malignant potential. Radiographic or clinical progression of ALs is uncommon. Malignancy should be suspected on the basis of a lesion's growth rate and size. A baseline hormonal work-up is recommended, and no further biochemical work-up is suggested when the initial assessment shows nonfunctioning lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Decreasing utilization for postoperative radiation therapy in locoregionally advanced medullary thyroid cancer.

Author

Maniakas, Anastasios, Sullivan, Andrew, Hu, Mimi I., Busaidy, Naifa L., Cabanillas, Maria E., Dadu, Ramona, Waguespack, Steven G., Fisher, Sarah B., Graham, Paul H., Gross, Neil D., Grubbs, Elizabeth G., Perrier, Nancy D., Wang, Jennifer R., Gunn, Brandon, Garden, Adam S., Megahed, Romy, Navuluri, Sriram, Li, Xu, Williams, Michelle D., and Zafereo, Mark

Subjects
MEDULLARY thyroid carcinoma, RADIOTHERAPY, OVERALL survival
Abstract

Background: Use of postoperative radiation therapy (PORT) in locoregionally advanced medullary thyroid cancer (MTC) remains controversial. The objective was to evaluate the effect of PORT on locoregional control (LRC) and overall survival (OS). Methods: Retrospective cohort study of 346 MTC patients separated into PORT and no‐PORT cohorts. Relative indications for PORT, as well as changes in patterns of treatment, were recorded. Results: 49/346 (14%) received PORT. PORT was associated with worse OS; adjusted HR = 2.0 (95%CI 1.3–3.3). PORT was not associated with improved LRC, even when adjusting for advanced stage (Stage III p = 0.892; Stage IV p = 0.101). PORT and targeted therapy were not associated with improved OS compared to targeted therapy alone; adjusted HR = 1.2 (95%CI 0.3–4.1). Conclusions: Use of PORT in MTC has decreased and its indications have become more selective, coinciding with the advent of effective targeted therapies. Overall, PORT was not associated with improved LRC or OS. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

Author

Colbert, Lauren E., primary, Petrova, Aleksandra V., primary, Fisher, Sarah B., primary, Pantazides, Brooke G., primary, Madden, Matthew Z., primary, Hardy, Claire W., primary, Warren, Matthew D., primary, Pan, Yunfeng, primary, Nagaraju, Ganji P., primary, Liu, Elaine A., primary, Saka, Burcu, primary, Hall, William A., primary, Shelton, Joseph W., primary, Gandhi, Khanjan, primary, Pauly, Rini, primary, Kowalski, Jeanne, primary, Kooby, David A., primary, El-Rayes, Bassel F., primary, Staley, Charles A., primary, Adsay, N. Volkan, primary, Curran, Walter J., primary, Landry, Jerome C., primary, Maithel, Shishir K., primary, and Yu, David S., primary

Published
2023
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39. Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

Author

Colbert, Lauren E., primary, Petrova, Aleksandra V., primary, Fisher, Sarah B., primary, Pantazides, Brooke G., primary, Madden, Matthew Z., primary, Hardy, Claire W., primary, Warren, Matthew D., primary, Pan, Yunfeng, primary, Nagaraju, Ganji P., primary, Liu, Elaine A., primary, Saka, Burcu, primary, Hall, William A., primary, Shelton, Joseph W., primary, Gandhi, Khanjan, primary, Pauly, Rini, primary, Kowalski, Jeanne, primary, Kooby, David A., primary, El-Rayes, Bassel F., primary, Staley, Charles A., primary, Adsay, N. Volkan, primary, Curran, Walter J., primary, Landry, Jerome C., primary, Maithel, Shishir K., primary, and Yu, David S., primary

Published
2023
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40. Data from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

Author

Colbert, Lauren E., primary, Petrova, Aleksandra V., primary, Fisher, Sarah B., primary, Pantazides, Brooke G., primary, Madden, Matthew Z., primary, Hardy, Claire W., primary, Warren, Matthew D., primary, Pan, Yunfeng, primary, Nagaraju, Ganji P., primary, Liu, Elaine A., primary, Saka, Burcu, primary, Hall, William A., primary, Shelton, Joseph W., primary, Gandhi, Khanjan, primary, Pauly, Rini, primary, Kowalski, Jeanne, primary, Kooby, David A., primary, El-Rayes, Bassel F., primary, Staley, Charles A., primary, Adsay, N. Volkan, primary, Curran, Walter J., primary, Landry, Jerome C., primary, Maithel, Shishir K., primary, and Yu, David S., primary

Published
2023
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41. Supplementary Tables 1 - 4 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer

Author

Colbert, Lauren E., primary, Petrova, Aleksandra V., primary, Fisher, Sarah B., primary, Pantazides, Brooke G., primary, Madden, Matthew Z., primary, Hardy, Claire W., primary, Warren, Matthew D., primary, Pan, Yunfeng, primary, Nagaraju, Ganji P., primary, Liu, Elaine A., primary, Saka, Burcu, primary, Hall, William A., primary, Shelton, Joseph W., primary, Gandhi, Khanjan, primary, Pauly, Rini, primary, Kowalski, Jeanne, primary, Kooby, David A., primary, El-Rayes, Bassel F., primary, Staley, Charles A., primary, Adsay, N. Volkan, primary, Curran, Walter J., primary, Landry, Jerome C., primary, Maithel, Shishir K., primary, and Yu, David S., primary

Published
2023
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45. Abstract NS4: Impact Of System-wide Implementation Of Tenecteplase For Ischemic Stroke Thrombolysis On Quality Metrics And Outcomes

Author

Tubergen, Tricia, primary, Fisher, Sarah B, additional, Kremers, Meghan, additional, Miller, Malgorzata, additional, Tsai, Jenny, additional, Kline, Andrew, additional, Min, Jiangyong, additional, Wees, Nabil, additional, Khan, Nadeem I, additional, Ahrar, Asad, additional, Singer, Justin, additional, Mazaris, Paul, additional, Packard, Laurel, additional, Oostema, John A, additional, and Khan, Muhib, additional

Published
2023
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49. Neoadjuvant checkpoint inhibitor immunotherapy for resectable mucosal melanoma

Author

Ho, Joel, primary, Mattei, Jane, additional, Tetzlaff, Michael, additional, Williams, Michelle D., additional, Davies, Michael A., additional, Diab, Adi, additional, Oliva, Isabella C. Glitza, additional, McQuade, Jennifer, additional, Patel, Sapna P., additional, Tawbi, Hussein, additional, Wong, Michael K., additional, Fisher, Sarah B., additional, Hanna, Ehab, additional, Keung, Emily Z., additional, Ross, Merrick, additional, Weiser, Roi, additional, Su, Shirley Y., additional, Frumovitz, Michael, additional, Meyer, Larissa A., additional, Jazaeri, Amir, additional, Pettaway, Curtis A., additional, Guadagnolo, B. Ashleigh, additional, Bishop, Andrew J., additional, Mitra, Devarati, additional, Farooqi, Ahsan, additional, Bassett, Roland, additional, Faria, Silvana, additional, Nagarajan, Priyadharsini, additional, and Amaria, Rodabe N., additional

Published
2022
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50. Parathyroidectomy for Normocalcemic Primary Hyperparathyroidism is Associated with Improved Bone Mineral Density Regardless of Postoperative Parathyroid Hormone Levels

Author

Lui, Michael S., primary, Clemente-Gutierrez, Uriel, additional, Vodopivec, Danica M., additional, Chang, Shandel L., additional, Shirali, Aditya S., additional, Huang, Bernice L., additional, Chiang, Yi-Ju, additional, Fisher, Sarah B., additional, Grubbs, Elizabeth G., additional, Guise, Theresa A., additional, Graham, Paul H., additional, and Perrier, Nancy D., additional

Published
2022
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