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179 results on '"Fishbein, James C."'

1. Preface

Author

Fishbein, James C., primary and Heilman, Jacqueline M., additional

Published
2019
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2. Preface

Author

Fishbein, James C., primary and Heilman, Jacqueline M., additional

Published
2018
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5. Preface

Author

Fishbein, James C., primary and Heilman, Jacqueline M., additional

Published
2017
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8. Preface

Author

Fishbein, James C., primary and Heilman, Jacqueline M., additional

Published
2015
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9. Preface

Author

Fishbein, James C., primary and Heilman, Jacqueline M., additional

Published
2014
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12. Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz

Author

Navamal, Mettachit, McGrath, Colleen, Stewart, Jennifer, Blans, Patrick, Villamena, Frederick, Zweier, Jay, and Fishbein, James C.

Subjects
Chemistry, Organic -- Research, Thiols, Metabolism -- Analysis, Metabolites, Biological sciences, Chemistry
Abstract

Research has been conducted on 7-methyl-6,8-bis(methyldisulfanyl)pyrrolo[1,2-a]pyrazine and methanethiosulfonic acid S-((6-methanesulfonylsulfanyl)-7-methyl)pyrrolo[1,2-a]pyrazin-8-yl) ester. The synthesis of these compounds has been carried out to investigate whether they can serve as alternative precursors to the major metabolites of the cancer chemopreventive oltipraz and whether their biological activities are similar.

Published
2002

14. Cyclic alpha-acetoxynitrosamines: mechanisms of decomposition and stability of alpha-hydroxynitrosamine and nitrosiminium ion reactive intermediates

Author

Chahoua, Latifa, Cai, Hongliang, and Fishbein, James C.

Subjects
Decomposition (Chemistry) -- Research, Ion exchange -- Research, Excited state chemistry -- Research, Chemistry
Abstract

An analysis of the mechanism and kinetics of decomposition of alpha-acetoxy-N-nitrosopiperidine and alpha-acetoxy-N-nitrosopyrrolidine was conducted on the basis of common ion inhibition, thermodynamic parameters and azide ion trapping. The compounds, which have a reactivity difference of over two orders of magnitude, were found to be undergoing the process of decay via the generation of N-nitrosiminium ion intermediates. This is seen as proof of the highly unstable reactive nature of the two cyclic alpha-hydroxynitrosamines.

Published
1999

17. alpha-(Acyloxy)dialkylnitrosamines: effects of structure on the formation of N-nitrosiminium ions and a predicted change in mechanism

Author

Cai, Hongliang and Fishbein, James C.

Subjects
Nitrosoamines -- Research, Molecular structure -- Research, Chemistry
Abstract

The decay of alpha-(acyloxy)dialkylnitrosamines in aqeous solutions has been investigated to determine the effects of structure on mechanism and reactivity. The rate constants (k1) for the pH-independent decay of 43 alpha-(acyloxy)dialkylnitrosamines were determined. The results indicate a mechanism that involves the formation of N-nitrosiminium ions in or before the rate-limiting step. It was also shown that the electronic properties of substituents at RN and Rc and the ability of substituents to engage in hyperconjugative interactions determine the stability of the compound.

Published
1999

18. Evidence for the formation of alpha-hydroxydialkylnitrosamines in the pH-independent solvolysis of alpha-(acyloxy)dialkylnitrosamines

Author

Chahoua, Latifa, Mesic, Milan, Revis, Cynthia L., Vigroux, Alain, and Fishbein, James C.

Subjects
Nitrosoamines -- Analysis, Amines -- Analysis, Organic compounds -- Synthesis, Biological sciences, Chemistry
Abstract

The solvolytic decay of alpha-(acyloxy)dialkylnitrosamines in aqueous solutions involved a hydrogen-ion concentration-independent mechanism that led to the formation of nitrosiminium ion intermediates. The nitrosonium ion intermediates form alpha-hydroxydialkylnitrosamines by reacting with solvent water. The nitroso group mediated the decomposition of the alpha-(acyloxy)dialkylnitrosamines to alpha-hyroxydialkylnitrosamines by providing anchimeric assistance in a base-catalyzed reaction.

Published
1997

19. Mechanics of decomposition of (Z)-2,2,2-trifluoro-1-arylethanediazoates in aqueous media

Author

Finneman, Jari I. and Fishbein, James C.

Subjects
Radiochemistry -- Analysis, Decomposition (Chemistry) -- Research, Scission (Chemistry) -- Research, Chemistry
Abstract

The mechanism of decay of three (Z)-2,2,2-trifluoro-1-arylethanediazoates reveals that a diazonium ion intermediate is formed from the decay of the diazoic acid in the case of the unsubstituted compound. Similar kinetics are noted for the two other compounds. The decay of the diazolic acids is observed to undergo general acid catalysis at pH

Published
1996

20. Reexamination of the mechanisms of decomposition of simple alpha-acetoxynitrosamines in the physiological pH range

Author

Revis, Cynthia L., Rajamaki, Markku, and Fishbein, James C.

Subjects
Decomposition (Chemistry) -- Research, Nitrosoamines -- Research, Biological sciences, Chemistry
Abstract

The mechanism for the buffer independent decay of alpha-(acyloxy)nitrosoamines was examined. The rate constants of eight compounds were determined in the pH range 2-13. The results showed no measurable assistance in the decomposition of the Z forms of the alpha-(acyloxy)nitrosoamines. It is shown the even the simplest alpha-acetoxynitrosoamine decays with the intermediacy of an N-nitrosimium cation.

Published
1995

21. Mechanisms of benzyl group transfer in the decay of (E)-arylmethanediazoates and aryldiazomethanes in aqueous solutions

Author

Finneman, Jari I. and Fishbein, James C.

Subjects
Chemical reaction, Rate of -- Research, Diazo compounds -- Research, Chemistry
Abstract

A study of rate constants for the buffer-independent decay of ten (E)-arylmethanediazoates in aqueous media at 25 degrees Celsius with 1 M (NaClO4) ionic strength shows that the rate limiting step for decomposition of (E)-arylmethanediazoates requires unimolecular decomposition of diazoic acid and rotational/translational reorientation of the nucleophiles in the carbocation substrates' first solvation sphere at high hydrogen ion concentrations. The rate constants are proportional to pH but they become independent of the hydrogen ion concentration at low pH. The required selectivities are produced due to preferential interaction with trifluoroethanol.

Published
1995

22. Changes in transition state structure for protonation of aryldiazomethanes in aqueous solutions

Author

Finneman, Jari I. and Fishbein, James C.

Subjects
Chemical reaction, Rate of -- Research, Azo compounds -- Research, Spectrophotometer -- Analysis, Biological sciences, Chemistry
Abstract

Kinetic studies of the decay of a series of aryldiazomethanes in aqueous media by stopped-flow spectrophotometric studies help determine the rate constants of decay. Solvent deuterium isotope effect shows that protonation by H2O is the rate-determining step. Proton transfer reactions of monoaryldiazomethanes accompany changes in the transition state structures. A comparative study of protonation of mono- and diaryldiazomethane shows that differences in reactivity are due to differences in the orientation of the reaction coordinates at the two transition states reactive to the orthogonal axes of a reaction coordinate diagram.

Published
1994

23. Rate-limiting formation of diazonium ions in the aqueous decomposition of primary alkanediazoates

Author

Ho, Jian and Fishbein, James C.

Subjects
Decomposition (Chemistry) -- Research, Scission (Chemistry) -- Observations, Chemistry
Abstract

Analyses of the influence of structure on rates and mechanisms of decomposition of primary alkanediazoates show that the unassisted heterolytic bond fission, producing diazonium ions, is the rate limiting step. pH-independent decomposition rate of (Z)-trifluoroethanediazoate is 2600 times more than that of E-isomer. At higher pH, hydrogen ion influences the rate of decomposition, while at low pH, hydrogen ion has no influence on the decomposition rate.

Published
1994

24. Mechanism of decomposition of (E)-methanediazoate in aqueous solution

Author

Hovinen, Jari, Finneman, Jari I., Satapathy, Surya N., Jian Ho, and Fishbein, James C.

Subjects
Decomposition (Chemistry) -- Research, Diazo compounds -- Analysis, Chemistry
Abstract

The mechanism of decomposition of (E)-methanediazoate was reported. It was shown that the rate-limiting step for decomposition of (E)-methanediazoate in the physiological pH region involves N-O bond fission of the diazoic acid to yield the methanediazonium ion. This conclusion permits the first semiquantitative description of methyl group transfer in aqueous solution from a diazoate.

Published
1992

25. Evidence for intermediates and a change in rate-limiting step in the aminolysis of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by cyclic amines

Author

Wichems, Desmond N., Nag, Shimona, Mills, Jane, and Fishbein, James C.

Subjects
Cyclic compounds -- Research, Amines -- Analysis, Chemistry
Abstract

An analysis of the reaction of certain cyclic amines confirms intermediates in the reactions of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) through a shift in the rate-limiting step. The inference on the nucleofugality of N-nitoromethylamine anion confirms that the anion is a feeble leaving group.

Published
1992

26. Thiolytic decomposition of the carcinogen N-methyl-N'-nitrosoguanidine. A change in rate-limiting step with nucleophile basicity controls alkylating activity

Author

Santala, Taina and Fishbein, James C.

Subjects
DNA -- Analysis, Thiols -- Research, Alkylation -- Analysis, Chemistry
Abstract

A methodical study of the alkanethiolate-stimulated decomposition of N-methyl-N'-nitro-N-nitoroguaidine (MNNG) in aqueous solution confirms that an intermediate effects the deamination reaction. The shift in rate-limiting step due to thiol anion basicity is evident from the transformation to predominant denitrosation for the reaction of less basic thiolate ions from deamination for the reaction of extremely basic thiolate anions.

Published
1992

28. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. - Provides cutting-edge reviews by leading workers in the discipline - Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians, and any student in the allied disciplines - Presents leading-edge applications of technological innovations in chemistry, biochemistry, and molecular medicine

Published
2017

29. Synthesis and aqueous chemistry of alpha-acetoxy-N-nitrosomorpholine: Reactive intermediates and products

Author

Zink, Charles N., Hyun-Joong Kim, and Fishbein, James C.

Subjects
Aqueous solution reactions -- Research, Oxidation-reduction reaction -- Analysis, Cyanides -- Chemical properties, Nitrogen compounds -- Chemical properties, Biological sciences, Chemistry
Abstract

Alpha-acetoxy-N-nitrosomorpholine is synthesized starting by the anodic oxidation of N-acetylorpholine in methanol. The 55% yield of N-nitrosomorpholinic acid, after cyanide-for-methoxy group exchange and hydrolysis, is an improvement of 10-fold over the original 10-step method, and this is readily converted to alpha-acetoxy-N-nitrosomorpholine.

Published
2006

30. Advances in Molecular Toxicology : Volume 7

Author

Fishbein, James C., Heilman, Jacqueline M., Fishbein, James C., Fishbein, James C., Heilman, Jacqueline M., and Fishbein, James C.

Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2013

31. Advances in Molecular Toxicology

Author

Fishbein, James C., Heilman, Jacqueline M., Fishbein, James C., and Heilman, Jacqueline M.

Subjects
Toxicology, Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2014

32. Advances in Molecular Toxicology

Author

Heilman, Jacqueline M., Fishbein, James C., Heilman, Jacqueline M., and Fishbein, James C.

Subjects
Toxicology, Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2013

33. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Molecular biology, Toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2012

35. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2011

37. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Toxicology, Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2010

39. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Published
2009

40. Advances in Molecular Toxicology

Author

Fishbein, James C. and Fishbein, James C.

Subjects
Molecular toxicology
Abstract

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed - Cutting edge reviews by leading workers in the discipline - In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines - Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine

Published
2008

41. Effects of structure on the reactivity of alpha-hydroxydialkylnitrosamines in aqueous solutions

Author

Mesic, Milan, Revis, Cynthia, and Fishbein, James C.

Subjects
Nitrosoamines -- Research, Reactivity (Chemistry) -- Research, Methanol -- Research, Chemistry
Abstract

A kinetic study of alpha-hydroxydialkylnitrosamines is conducted to determine structural effects on their chemistry and reactivity. The results suggest that, indeed, structural modifications afford a major influence on their stability or lifetime. Specifically, the rate constants for the denaturation of alpha-hydroxydialkylnitrosamines in aqueous solution indicate that variations in hydroxymethyl moieties have noticeable impact on reactivity. The compounds were prepared based on existing procedures that required triphenylphosphine reduction of the alpha-hydroperoxy precursors.

Published
1996

42. N-nitrosiminium ions are ambident electrophiles

Author

Rajamaki, Markku, Vigroux, Alain, Chahoua, Latifa, and Fishbein, James C.

Subjects
Cations -- Research, Biological sciences, Chemistry
Abstract

The N-nitrosiminium ions are ambident electrophiles which are denitrosated by specific nucleophiles. During the denitrosation, the nitroso group is removed, resulting in the damaging of the alkylating activity of the N-nitrosamine precursor is a novel detoxification pathway. The decomposition of (N-nitroso-N-methylamino)- (4-methoxyphenyl)methyl azide is possible at high azide ion concentration through denitrosation.

Published
1995

43. Generation and direct measurement of the reactivity of an N-nitrosiminium cation with nucleophiles in aqueous media

Author

Vigroux, Alain, Kresge, A. Jerry, and Fishbein, James C.

Subjects
Reactivity (Chemistry) -- Research, Laser photochemistry -- Usage, Cations -- Research, Nitrosoamines -- Research, Chemistry
Abstract

Laser flash photolysis can be used to determine the rate constants of the reactions of a variety of nucleophilic/basic substances with the N-nitrosiminium cation. The cation is less reactive by a factor of 10 to the fifth power than the benzyl cation for solvent capture in aqueous alcoholic media. For the reaction of the acetate ion, the mechanism is nucleophilic as examined by the common ion effect. Alpha-phosphonooxy-N-nitrosamines are formed during the decomposition of various alpha-acetoxy-N-nitrosamines in the presence of phosphate buffers.

Published
1995

45. Evidence of Formation of alpha-Hydroxydialkylnitrosamines in the pH-Independent Solvolysis of alpha-Acyloxydialkylnitrosamin

Author

Chahoua, Latifa, Mesić, Milan, Revis, Cynthia, Vigroux, Alain, and Fishbein, James C.

Subjects
alpha-Hydroxydialkylnitrosamines, solvolysis, alpha-acyloxydialkylnitrosamines
Abstract

A kinetic study of the decay of alpha-(acyloxy)dialkylnitrosamines in aqueous solutions, at 25 degrees C, ionic strength 1 M (NaClO4), and 4% acetonitrile by volume, is reported. Rate constants for disappearance of the N-NO chromophore or appearance of benzaldehyde product increase with the introduction of electron-withdrawing groups into the acyloxy moiety. For some compounds, in some regions of pH, the kinetics are non-first-order, For these compounds, in other regions of pH, the rate constants are coincident with those previously reported for the decay of the corresponding alpha-hydroxydialkylnitrosamines. These data provide direct evidence that alpha-hydroxydialkylnitrosamines are intermediates in the pH-independent decomposition of the alpha-(acyloxy)dialkylnitrosamines studied.

Published
1997

46. (E)-2-butanediazoic acid decomposes via a diazonium ion intermediate

Author

Finneman, Jari I., Ho, Jian, and Fishbein, James C.

Subjects
Diazo compounds -- Research, Diazo reaction -- Research, Chemical reactions -- Research, Decomposition (Chemistry) -- Research, Chemistry
Abstract

The direct kinetic analysis of the decomposition of a pair of secondary anti alkanediazoates in aqueous media is presented. A comparison of the rate constants of the two diazoic acids show that the mechanism of decomposition of the 2-butyl compound involves the formation of the diazonium ions. If the decomposition process had gone another way, the carbenium ion character in the transition state would be stabilized by the resonance interaction in the benzene ring. The secondary diazonium ion was found to be more stable compared to the methanediazonium ion.

Published
1993

48. Rate constants for the decomposition of a simple alkanediazoate at physiological pH

Author

Hovinen, Jari and Fishbein, James C.

Subjects
Diazo compounds -- Research, Decomposition (Chemistry) -- Research, Chemistry
Abstract

Potassium (E)-methanediazoate, an anti-alkanediazoate, is synthesized and subjected to a decomposition study. Alkanediazoates are putative intermediates in the DNA-alkylation process by compounds with N-nitroso-N-alkyl functionality. They are known as either cancer-causing or chemotherapeutic agents. The kinetic study is the first attempt to establish the empirical basis for working out the mechanism of the decomposition. The results of the experiment, along with the derived rate law for the reaction and the proposed reaction mechanism, are discussed.

Published
1992

49. Novel, Broad Spectrum Anticancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System

Author

Kondaskar, Atul, primary, Kondaskar, Shilpi, additional, Kumar, Raj, additional, Fishbein, James C., additional, Muvarak, Nidal, additional, Lapidus, Rena G., additional, Sadowska, Mariola, additional, Edelman, Martin J., additional, Bol, Guus M., additional, Vesuna, Farhad, additional, Raman, Venu, additional, and Hosmane, Ramachandra S., additional

Published
2010
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