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1. A more-Comers populAtion trEated with an ultrathin struts polimer-free Sirolimus stent: an Italian post-maRketing study (the CAESAR registry)

Author

Tarantini, Giuseppe, primary, Cardaioli, Francesco, additional, De Iaco, Giuseppe, additional, Tuccillo, Bernardino, additional, De Angelis, Maria Carmen, additional, Mauro, Ciro, additional, Boccalatte, Marco, additional, Trivisonno, Antonio, additional, Ribichini, Flavio, additional, Vadalà, Giuseppe, additional, Caramanno, Giuseppe, additional, Caruso, Marco, additional, Lombardi, Mario, additional, Fischetti, Dionigi, additional, Danesi, Alessandro, additional, Abbracciavento, Leonardo, additional, Lorenzoni, Giulia, additional, Gregori, Dario, additional, Panza, Andrea, additional, Nai Fovino, Luca, additional, and Esposito, Giovanni, additional

Published
2024
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2. TCT-480 Severe Aortic Stenosis and Concomitant Complex, High-Risk PCI: Current Management and Survival in Large Volume Centers

Author

Montalto, Claudio, primary, Regazzoli, Damiano, additional, Arslani, Ketina, additional, Brunner, Stephanie, additional, Mangieri, Antonio, additional, Verhemel, Sarah, additional, Buono, Andrea, additional, Squillace, Mattia, additional, Diez-Gil, Jose L., additional, Foroni, Marco, additional, Mandurino-Mirizzi, Alessandro, additional, Bauer, Dávid, additional, Piayda, Kerstin, additional, Sievert, Kolja, additional, Zecchino, Simone, additional, de Ornelas, Benjamin, additional, Esposito, Giuseppe, additional, Munafò, Andrea, additional, Cozzi, Ottavia, additional, Nava, Stefano, additional, Bruschi, Giuseppe, additional, Porto, Italo, additional, Kornowski, Ran, additional, Toušek, Petr, additional, Fischetti, Dionigi, additional, Maffeo, Diego, additional, Bedogni, Francesco, additional, Sanchez, Jorge Sanz, additional, Sievert, Horst, additional, Saia, Francesco, additional, Van Mieghem, Nicolas, additional, Toggweiler, Stefan, additional, and De Backer, Ole, additional

Published
2023
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3. Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial

Author

Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Presbitero, Patrizia, Zavalloni-Parenti, Dennis, Ferrari, Fabio, Ceravolo, Roberto, Tarantino, Fabio, Pasquetto, Giampaolo, Casu, Gavino, Mameli, Stefano, Stochino, Maria Letizia, Mazzarotto, Pietro, Cremonesi, Alberto, Saia, Francesco, Saccone, Giovanni, Abate, Fabio, Picchi, Andrea, Violini, Roberto, Colangelo, Salvatore, Boccuzzi, Giacomo, Guiducci, Vincenzo, Vigna, Carlo, Zingarelli, Antonio, Gagnor, Andrea, Zaro, Tiziana, Tresoldi, Simone, Vandoni, Pietro, Contarini, Marco, Liso, Armando, Dellavalle, Antonio, Curello, Salvatore, Mangiacapra, Fabio, Evola, Rosario, Palmieri, Cataldo, Falcone, Camillo, Liistro, Francesco, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Perkan, Andrea, De Servi, Stefano, Fischetti, Dionigi, Rigattieri, Stefano, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, De Caterina, Raffaele, Caputo, Marcello, Zimmarino, Marco, Bramucci, Ezio, Di Lorenzo, Emilio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Loi, Bruno, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Micari, Antonio, Belloni, Flavia, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Klinieken, Isala, Van Mieghem, Nicolas, Diletti, Roberto, Regar, Evelyn, Sabaté, Manel, Gómez Hospital, Joan Antoni, Díaz Fernández, José Francisco, Mainar, Vicente, de la Torre Hernandez, Jose Maria, Valgimigli, Marco, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Rothenbühler, Martina, Tebaldi, Matteo, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Rubartelli, Paolo, Briguori, Carlo, Andó, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, de Cesare, Nicoletta, Tosi, Paolo, van 't Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, Heg, Dik, and Jüni, Peter

Published
2018
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4. Intracoronary Pacing during “Chimney Technique” in Transcatheter Aortic Valve-in-Valve Implantation: An Alternative Temporary Rapid Ventricular Stimulation?

Author

Cafaro, Alessandro, primary, Rizzo, Francesco, additional, Fischetti, Dionigi, additional, Quarta, Luca, additional, Mussardo, Marco, additional, Mandurino-Mirizzi, Alessandro, additional, Tondo, Antonio, additional, Ciccone, Marco Matteo, additional, Iacovelli, Fortunato, additional, and Colonna, Giuseppe, additional

Published
2023
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10. [Updated SICI-GISE position paper on institutional and operator requirements for transcatheter aortic valve implantation]

Author

Tarantini, Giuseppe, Esposito, Giovanni, Musumeci, Giuseppe, Fraccaro, Chiara, Franzone, Anna, Castiglioni, Battistina, La Manna, Alessio, Limbruno, Ugo, Marchese, Alfredo, Mauro, Ciro, Rigattieri, Stefano, Tarantino, Fabio, Gandolfo, Caterina, Santoro, Gennaro, Violini, Roberto, Airoldi, Flavio, Albiero, Remo, Balbi, Manrico, Baralis, Giorgio, Bartorelli, Antonio Luca, Bedogni, Francesco, Benassi, Alberto, Berni, Andrea, Bonzani, Giulio, Bortone, Alessandro Santo, Braito, Giuseppe, Briguori, Carlo, Brscic, Elvis, Calabrò, Paolo, Calchera, Ivan, Cappelli Bigazzi, Maurizio, Caprioglio, Francesco, Castriota, Fausto, Cernetti, Carlo, Cicala, Cinzia, Cioffi, Paolo, Colombo, Antonio, Colombo, Virgilio, Contegiacomo, Gaetano, Cremonesi, Alberto, D'Amico, Maurizio, De Benedictis, Mauro, De Leo, Alessandro, Di Biasi, Maurizio, Di Girolamo, Domenico, Di Lorenzo, Emilio, Di Mario, Carlo, Dominici, Marcello, Ettori, Federica, Ferrario, Maurizio, Fioranelli, Massimo, Fischetti, Dionigi, Gabrielli, Gabriele, Giordano, Arturo, Giudice, Pietro, Greco, Cesare, Indolfi, Ciro, Leonzi, Ornella, Lettieri, Corrado, Loi, Bruno, Maddestra, Nicola, Marchionni, Niccolò, Marrozzini, Cinzia, Medda, Massimo, Missiroli, Bindo, My, Luigi, Oreglia, Jacopo Andrea, Palmieri, Cataldo, Pantaleo, Paolo, Paparoni, Saro Roberto, Parodi, Guido, Petronio, Anna Sonia, Piatti, Luigi, Piccaluga, Emanuela, Pierli, Carlo, Perkan, Andrea, Pitì, Antonino, Poli, Arnaldo, Ramondo, Angelo Bruno, Reale, Maurizio Alessandro, Reimers, Bernhard, Ribichini, Flavio Luciano, Rosso, Roberta, Saccà, Salvatore, Sacra, Cosimo, Santarelli, Andrea, Sardella, Gennaro, Satullo, Gaetano, Scalise, Filippo, Siviglia, Massimo, Spedicato, Leonardo, Stabile, Amerigo, Tamburino, Corrado, Tesorio, Tullio Nicola Maria, Tolaro, Salvatore, Tomai, Fabrizio, Trani, Carlo, Valenti, Renato, Valsecchi, Orazio, Valva, Giuseppe, Varbella, Ferdinando, Vigna, Carlo, Vignali, Luigi, Berti, Sergio, Tarantini, Giuseppe, Esposito, Giovanni, Musumeci, Giuseppe, Fraccaro, Chiara, Franzone, Anna, Castiglioni, Battistina, La Manna, Alessio, Limbruno, Ugo, Marchese, Alfredo, Mauro, Ciro, Rigattieri, Stefano, Tarantino, Fabio, Gandolfo, Caterina, Santoro, Gennaro, Violini, Roberto, Airoldi, Flavio, Albiero, Remo, Balbi, Manrico, Baralis, Giorgio, Bartorelli, Antonio Luca, Bedogni, Francesco, Benassi, Alberto, Berni, Andrea, Bonzani, Giulio, Bortone, Alessandro Santo, Braito, Giuseppe, Briguori, Carlo, Brscic, Elvi, Calabrò, Paolo, Calchera, Ivan, Cappelli Bigazzi, Maurizio, Caprioglio, Francesco, Castriota, Fausto, Cernetti, Carlo, Cicala, Cinzia, Cioffi, Paolo, Colombo, Antonio, Colombo, Virgilio, Contegiacomo, Gaetano, Cremonesi, Alberto, D'Amico, Maurizio, De Benedictis, Mauro, De Leo, Alessandro, Di Biasi, Maurizio, Di Girolamo, Domenico, Di Lorenzo, Emilio, Di Mario, Carlo, Dominici, Marcello, Ettori, Federica, Ferrario, Maurizio, Fioranelli, Massimo, Fischetti, Dionigi, Gabrielli, Gabriele, Giordano, Arturo, Giudice, Pietro, Greco, Cesare, Indolfi, Ciro, Leonzi, Ornella, Lettieri, Corrado, Loi, Bruno, Maddestra, Nicola, Marchionni, Niccolò, Marrozzini, Cinzia, Medda, Massimo, Missiroli, Bindo, My, Luigi, Oreglia, Jacopo Andrea, Palmieri, Cataldo, Pantaleo, Paolo, Paparoni, Saro Roberto, Parodi, Guido, Petronio, Anna Sonia, Piatti, Luigi, Piccaluga, Emanuela, Pierli, Carlo, Perkan, Andrea, Pitì, Antonino, Poli, Arnaldo, Ramondo, Angelo Bruno, Reale, Maurizio Alessandro, Reimers, Bernhard, Ribichini, Flavio Luciano, Rosso, Roberta, Saccà, Salvatore, Sacra, Cosimo, Santarelli, Andrea, Sardella, Gennaro, Satullo, Gaetano, Scalise, Filippo, Siviglia, Massimo, Spedicato, Leonardo, Stabile, Amerigo, Tamburino, Corrado, Tesorio, Tullio Nicola Maria, Tolaro, Salvatore, Tomai, Fabrizio, Trani, Carlo, Valenti, Renato, Valsecchi, Orazio, Valva, Giuseppe, Varbella, Ferdinando, Vigna, Carlo, Vignali, Luigi, and Berti, Sergio

Subjects
Transcatheter aortic valve implantation, Transcatheter aortic valve implantation, TAVI, severe aortic stenosis, Operators, Biomedical Technology, Requirements, Aortic Valve Stenosis, Institutions, Severity of Illness Index, Transcatheter Aortic Valve Replacement, TAVI, Italy, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Training, Humans, Program Development, severe aortic stenosis
Abstract

Transcatheter aortic valve implantation (TAVI) has revolutionized the management of patients with symptomatic severe aortic stenosis and has become the standard of care for inoperable patients and the preferred therapy for those at increased surgical risk with peculiar clinical and anatomic features. Technology advances, growing experience and accumulating data prompted the update of the 2011 Italian Society of Interventional Cardiology (SICI-GISE) position paper on institutional and operator requirements to perform TAVI. The main objective of this document is to provide a guidance to assess the potential of institutions and operators to initiate and maintain an efficient TAVI program.

Published
2018

11. Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management: AKI-MATRIX

Author

Andã², Giuseppe, Cortese, Bernardo, Russo, Filippo, Rothenbã¼hler, Martina, Frigoli, Enrico, Briguori, Carlo, Vranckx, Pascal, Leonardi, Sergio, Guiducci, Vincenzo, Belloni, Flavia, Ferrari, Fabio, De La Torre Hernandez, Jose Maria, Curello, Salvatore, Liistro, Francesco, Perkan, Andrea, De Servi, Stefano, Casu, Gavino, Dellavalle, Antonio, Fischetti, Dionigi, Micari, Antonio, Loi, Bruno, Mangiacapra, Fabio, Russo, Nunzio, Tarantino, Fabio, Saia, Francesco, Heg, Dik, Windecker, Stephan, Jã¼ni, Peter, Valgimigli, Marco, Salomone, Maria, Occhilupo, Pierpaolo, Lodolini, Veronica, Monti, Monia, Mazzone, Maria Grazia, Delos, Erika, Caruso, Maria Teresa, Testa, Maggie, Ciociano, Nestor, Lazzero, Maurizio, Gazzotti, Davide, Cagliari, Lorenzo, Shahmohammadi, Leila, Caiazza, Martina, Virga, Vittorio, Guerra, Elena, Michalska, Eva, Castellini, Sara, Serino, Vincenzo, Visconti, Gabriella, Pendenza, Gianluca, Portolan, Monica, Anzini, Marco, Silvetti, Elisa, Coco, Tiziana, Costa, Francesco, Ariotti, Sara, Valli, Linda, Adamo, Marianna, Marino, Marcello, Tricoci, Pierluigi, Gagnor, Andrea, Calabrã, Paolo, Rubartelli, Paolo, Garducci, Stefano, Santarelli, Andrea, Galli, Mario, Garbo, Roberto, Bramucci, Ezio, Ierna, Salvatore, Limbruno, Ugo, Violini, Roberto, Presbitero, Patrizia, De Cesare, Nicoletta, Sganzerla, Paolo, Ausiello, Arturo, Tosi, Paolo, Sardella, Gennaro, Sabate, Manel, Brugaletta, Salvatore, Saccone, Giovanni, Vandoni, Pietro, Zingarelli, Antonio, Liso, Armando, Rigattieri, Stefano, Di Lorenzo, Emilio, Vigna, Carlo, Palmieri, Cataldo, Falcone, Camillo, De Caterina, Raffaele, Caputo, Marcello, Lupi, Alessandro, Mazzarotto, Pietro, Varbella, Fernando, Zaro, Tiziana, Nazzaro, Marco, Rao, Sunil V., Van‘t Hof, Arnoud W. J., Omerovic, Elmir, Calabrã², Paolo, Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Zavalloni parenti, Dennis, Ceravolo, Roberto, Pasquetto, Giampaolo, Esposito, Giovanni, Mameli, Stefano, Stochino, Maria Letizia, Cremonesi, Alberto, Abate, Fabio, Picchi, Andrea, Colangelo, Salvatore, Boccuzzi, Giacomo, Varbella, Ferdinando, Tresoldi, Stefano, Contarini, Marco, Evola, Rosario, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, Zimmarino, Marco, Ferrario, Maurizio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Van Mieghem, Nicolas, Diletti, Roberto, Regar, Evelyn, Sabatã©, Manel, Gã³mez Hospital, Joan Antoni, Dã­az Fernã¡ndez, Josã© Francisco, Mainar, Vicente, GARGIULO, GIUSEPPE, ESPOSITO, GIOVANNI, Andã², Giuseppe, Cortese, Bernardo, Russo, Filippo, Rothenbã¼hler, Martina, Frigoli, Enrico, Gargiulo, Giuseppe, Briguori, Carlo, Vranckx, Pascal, Leonardi, Sergio, Guiducci, Vincenzo, Belloni, Flavia, Ferrari, Fabio, De La Torre Hernandez, Jose Maria, Curello, Salvatore, Liistro, Francesco, Perkan, Andrea, De Servi, Stefano, Casu, Gavino, Dellavalle, Antonio, Fischetti, Dionigi, Micari, Antonio, Loi, Bruno, Mangiacapra, Fabio, Russo, Nunzio, Tarantino, Fabio, Saia, Francesco, Heg, Dik, Windecker, Stephan, Jã¼ni, Peter, Valgimigli, Marco, Salomone, Maria, Occhilupo, Pierpaolo, Lodolini, Veronica, Monti, Monia, Mazzone, Maria Grazia, Delos, Erika, Caruso, Maria Teresa, Testa, Maggie, Ciociano, Nestor, Lazzero, Maurizio, Gazzotti, Davide, Cagliari, Lorenzo, Shahmohammadi, Leila, Caiazza, Martina, Virga, Vittorio, Guerra, Elena, Michalska, Eva, Castellini, Sara, Serino, Vincenzo, Visconti, Gabriella, Pendenza, Gianluca, Portolan, Monica, Anzini, Marco, Silvetti, Elisa, Coco, Tiziana, Costa, Francesco, Ariotti, Sara, Valli, Linda, Adamo, Marianna, Marino, Marcello, Tricoci, Pierluigi, Gagnor, Andrea, Calabrã, Paolo, Rubartelli, Paolo, Garducci, Stefano, Santarelli, Andrea, Galli, Mario, Garbo, Roberto, Bramucci, Ezio, Ierna, Salvatore, Limbruno, Ugo, Violini, Roberto, Presbitero, Patrizia, De Cesare, Nicoletta, Sganzerla, Paolo, Ausiello, Arturo, Tosi, Paolo, Sardella, Gennaro, Sabate, Manel, Brugaletta, Salvatore, Saccone, Giovanni, Vandoni, Pietro, Zingarelli, Antonio, Liso, Armando, Rigattieri, Stefano, Di Lorenzo, Emilio, Vigna, Carlo, Palmieri, Cataldo, Falcone, Camillo, De Caterina, Raffaele, Caputo, Marcello, Esposito, Giovanni, Lupi, Alessandro, Mazzarotto, Pietro, Varbella, Fernando, Zaro, Tiziana, Nazzaro, Marco, Rao, Sunil V., Vanâ t Hof, Arnoud W. J., Omerovic, Elmir, Calabrã², Paolo, Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Zavalloni parenti, Denni, Ceravolo, Roberto, Pasquetto, Giampaolo, Mameli, Stefano, Stochino, Maria Letizia, Cremonesi, Alberto, Abate, Fabio, Picchi, Andrea, Colangelo, Salvatore, Boccuzzi, Giacomo, Varbella, Ferdinando, Tresoldi, Stefano, Contarini, Marco, Evola, Rosario, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, Zimmarino, Marco, Ferrario, Maurizio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Van Mieghem, Nicola, Diletti, Roberto, Regar, Evelyn, Sabatã©, Manel, Gã³mez Hospital, Joan Antoni, Dã­az Fernã¡ndez, Josã© Francisco, and Mainar, Vicente

Subjects
estimated glomerular filtration rate, creatinine, coronary intervention, ST-segment elevation, bleeding, Cardiology and Cardiovascular Medicine
Published
2017

13. Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management: AKI-MATRIX

Author

Investigators, MATRIX, De La Torre Hernandez, Jose Maria, Cortese, Bernardo, Saia, Francesco, Rothenbühler, Martina, Guiducci, Vincenzo, Heg, Dik, Andò, Giuseppe, Micari, Antonio, Mangiacapra, Fabio, Leonardi, Sergio, De Servi, Stefano, Perkan, Andrea, Tarantino, Fabio, Gargiulo, Giuseppe, Dellavalle, Antonio, Russo, Nunzio, Fischetti, Dionigi, Russo, Filippo, Frigoli, Enrico, Valgimigli, Marco, Windecker, Stephan, Belloni, Flavia, Ferrari, Fabio, Loi, Bruno, Liistro, Francesco, Casu, Gavino, Vranckx, Pascal, Briguori, Carlo, Curello, Salvatore, and Jüni, Peter

Subjects
610 Medicine & health, 360 Social problems & social services
Abstract

BACKGROUND It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI). OBJECTIVES The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in the MATRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial. METHODS Among 8,404 patients, 194 (2.3%) were excluded due to missing creatinine values, no or an incomplete coronary angiogram, or previous dialysis. The primary AKI-MATRIX endpoint was AKI, defined as an absolute (>0.5 mg/dl) or a relative (>25%) increase in serum creatinine (sCr). RESULTS AKI occurred in 634 patients (15.4%) with RA and 712 patients (17.4%) with FA (odds ratio [OR]: 0.87; 95% confidence interval [CI]: 0.77 to 0.98; p = 0.0181). A >25% sCr increase was noted in 633 patients (15.4%) with RA and 710 patients (17.3%) with FA (OR: 0.87; 95% CI: 0.77 to 0.98; p = 0.0195), whereas a >0.5 mg/dl absolute sCr increase occurred in 175 patients (4.3%) with RA versus 223 patients (5.4%) with FA (OR: 0.77; 95% CI: 0.63 to 0.95; p = 0.0131). By implementing the Kidney Disease Improving Global Outcomes criteria, AKI was 3-fold less prevalent and trended lower with RA (OR: 0.85; 95% CI: 0.70 to 1.03; p = 0.090), with stage 3 AKI occurring in 28 patients (0.68%) with RA versus 46 patients (1.12%) with FA (p = 0.0367). Post-intervention dialysis was needed in 6 patients (0.15%) with RA and 14 patients (0.34%) with FA (p = 0.0814). Stratified analyses suggested greater benefit with RA than FA in patients at greater risk for AKI. CONCLUSIONS In ACS patients who underwent invasive management, RA was associated with a reduced risk of AKI compared with FA. (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX [MATRIX]; NCT01433627).

Published
2017
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14. Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial

Author

Valgimigli, Marco, primary, Frigoli, Enrico, additional, Leonardi, Sergio, additional, Vranckx, Pascal, additional, Rothenbühler, Martina, additional, Tebaldi, Matteo, additional, Varbella, Ferdinando, additional, Calabrò, Paolo, additional, Garducci, Stefano, additional, Rubartelli, Paolo, additional, Briguori, Carlo, additional, Andó, Giuseppe, additional, Ferrario, Maurizio, additional, Limbruno, Ugo, additional, Garbo, Roberto, additional, Sganzerla, Paolo, additional, Russo, Filippo, additional, Nazzaro, Marco, additional, Lupi, Alessandro, additional, Cortese, Bernardo, additional, Ausiello, Arturo, additional, Ierna, Salvatore, additional, Esposito, Giovanni, additional, Ferrante, Giuseppe, additional, Santarelli, Andrea, additional, Sardella, Gennaro, additional, de Cesare, Nicoletta, additional, Tosi, Paolo, additional, van 't Hof, Arnoud, additional, Omerovic, Elmir, additional, Brugaletta, Salvatore, additional, Windecker, Stephan, additional, Heg, Dik, additional, Jüni, Peter, additional, Campo, Gianluca, additional, Uguccioni, Lucia, additional, Tamburino, Corrado, additional, Presbitero, Patrizia, additional, Zavalloni-Parenti, Dennis, additional, Ferrari, Fabio, additional, Ceravolo, Roberto, additional, Tarantino, Fabio, additional, Pasquetto, Giampaolo, additional, Casu, Gavino, additional, Mameli, Stefano, additional, Stochino, Maria Letizia, additional, Mazzarotto, Pietro, additional, Cremonesi, Alberto, additional, Saia, Francesco, additional, Saccone, Giovanni, additional, Abate, Fabio, additional, Picchi, Andrea, additional, Violini, Roberto, additional, Colangelo, Salvatore, additional, Boccuzzi, Giacomo, additional, Guiducci, Vincenzo, additional, Vigna, Carlo, additional, Zingarelli, Antonio, additional, Gagnor, Andrea, additional, Zaro, Tiziana, additional, Tresoldi, Simone, additional, Vandoni, Pietro, additional, Contarini, Marco, additional, Liso, Armando, additional, Dellavalle, Antonio, additional, Curello, Salvatore, additional, Mangiacapra, Fabio, additional, Evola, Rosario, additional, Palmieri, Cataldo, additional, Falcone, Camillo, additional, Liistro, Francesco, additional, Creaco, Manuela, additional, Colombo, Antonio, additional, Chieffo, Alaide, additional, Perkan, Andrea, additional, De Servi, Stefano, additional, Fischetti, Dionigi, additional, Rigattieri, Stefano, additional, Sciahbasi, Alessandro, additional, Pucci, Edoardo, additional, Romagnoli, Enrico, additional, Moretti, Claudio, additional, Moretti, Luciano, additional, De Caterina, Raffaele, additional, Caputo, Marcello, additional, Zimmarino, Marco, additional, Bramucci, Ezio, additional, Di Lorenzo, Emilio, additional, Turturo, Maurizio, additional, Bonmassari, Roberto, additional, Penzo, Carlo, additional, Loi, Bruno, additional, Mauro, Ciro, additional, Petronio, Anna Sonia, additional, Gabrielli, Gabriele, additional, Micari, Antonio, additional, Belloni, Flavia, additional, Amico, Francesco, additional, Comeglio, Marco, additional, Fresco, Claudio, additional, Klinieken, Isala, additional, Van Mieghem, Nicolas, additional, Diletti, Roberto, additional, Regar, Evelyn, additional, Sabaté, Manel, additional, Gómez Hospital, Joan Antoni, additional, Díaz Fernández, José Francisco, additional, Mainar, Vicente, additional, and de la Torre Hernandez, Jose Maria, additional

Published
2018
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15. Sustained safety and clinical performance of a drug-eluting absorbable metal scaffold up to 24 months: pooled outcomes of BIOSOLVE-II and BIOSOLVE-III

Author

Testa, Luca, primary, De Carlo, Marco, additional, Petrolini, Alessandro, additional, Rapetto, Claudio, additional, Varbella, Ferdinando, additional, Cortese, Bernardo, additional, Gabrielli, Gabriele, additional, Geraci, Salvatore, additional, Loi, Bruno, additional, Boccuzzi, Giacomo, additional, Tarantini, Giuseppe, additional, Fischetti, Dionigi, additional, Calabria, Paolo, additional, Tomai, Fabrizio, additional, Ribichini, Flavio, additional, Tamburino, Corrado, additional, Indolfi, Ciro, additional, Bartorelli, Antonio, additional, Petronio, Anna Sonia, additional, and Bedogni, Francesco, additional

Published
2017
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16. One-year clinical results of the Italian diffuse/multivessel disease ABSORB prospective registry (IT-DISAPPEARS)

Author

Testa, Luca, primary, De Carlo, Marco, additional, Petrolini, Alessandro, additional, Rapetto, Claudio, additional, Varbella, Ferdinando, additional, Cortese, Bernardo, additional, Gabrielli, Gabriele, additional, Geraci, Salvatore, additional, Loi, Bruno, additional, Boccuzzi, Giacomo, additional, Tarantini, Giuseppe, additional, Fischetti, Dionigi, additional, Calabria, Paolo, additional, Tomai, Fabrizio, additional, Ribichini, Flavio, additional, Tamburino, Corrado, additional, Indolfi, Ciro, additional, Bartorelli, Antonio, additional, Petronio, Anna Sonia, additional, and Bedogni, Francesco, additional

Published
2017
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17. Acute Kidney Injury After Radial or Femoral Access for Invasive Acute Coronary Syndrome Management

Author

Andò, Giuseppe, primary, Cortese, Bernardo, additional, Russo, Filippo, additional, Rothenbühler, Martina, additional, Frigoli, Enrico, additional, Gargiulo, Giuseppe, additional, Briguori, Carlo, additional, Vranckx, Pascal, additional, Leonardi, Sergio, additional, Guiducci, Vincenzo, additional, Belloni, Flavia, additional, Ferrari, Fabio, additional, de la Torre Hernandez, Jose Maria, additional, Curello, Salvatore, additional, Liistro, Francesco, additional, Perkan, Andrea, additional, De Servi, Stefano, additional, Casu, Gavino, additional, Dellavalle, Antonio, additional, Fischetti, Dionigi, additional, Micari, Antonio, additional, Loi, Bruno, additional, Mangiacapra, Fabio, additional, Russo, Nunzio, additional, Tarantino, Fabio, additional, Saia, Francesco, additional, Heg, Dik, additional, Windecker, Stephan, additional, Jüni, Peter, additional, Valgimigli, Marco, additional, Salomone, Maria, additional, Occhilupo, Pierpaolo, additional, Lodolini, Veronica, additional, Monti, Monia, additional, Mazzone, Maria Grazia, additional, Delos, Erika, additional, Caruso, Maria Teresa, additional, Testa, Maggie, additional, Ciociano, Nestor, additional, Lazzero, Maurizio, additional, Gazzotti, Davide, additional, Cagliari, Lorenzo, additional, Shahmohammadi, Leila, additional, Caiazza, Martina, additional, Virga, Vittorio, additional, Guerra, Elena, additional, Michalska, Eva, additional, Castellini, Sara, additional, Serino, Vincenzo, additional, Visconti, Gabriella, additional, Pendenza, Gianluca, additional, Portolan, Monica, additional, Anzini, Marco, additional, Silvetti, Elisa, additional, Coco, Tiziana, additional, Costa, Francesco, additional, Ariotti, Sara, additional, Valli, Linda, additional, Adamo, Marianna, additional, Marino, Marcello, additional, Tricoci, Pierluigi, additional, Gagnor, Andrea, additional, Calabrò, Paolo, additional, Rubartelli, Paolo, additional, Garducci, Stefano, additional, Andò, Giuseppe, additional, Santarelli, Andrea, additional, Galli, Mario, additional, Garbo, Roberto, additional, Bramucci, Ezio, additional, Ierna, Salvatore, additional, Limbruno, Ugo, additional, Violini, Roberto, additional, Presbitero, Patrizia, additional, de Cesare, Nicoletta, additional, Sganzerla, Paolo, additional, Ausiello, Arturo, additional, Tosi, Paolo, additional, Sardella, Gennaro, additional, Sabate’, Manel, additional, Brugaletta, Salvatore, additional, Saccone, Giovanni, additional, Vandoni, Pietro, additional, Zingarelli, Antonio, additional, Liso, Armando, additional, Rigattieri, Stefano, additional, Di Lorenzo, Emilio, additional, Vigna, Carlo, additional, Palmieri, Cataldo, additional, Falcone, Camillo, additional, De Caterina, Raffaele, additional, Caputo, Marcello, additional, Esposito, Giovanni, additional, Lupi, Alessandro, additional, Mazzarotto, Pietro, additional, Varbella, Fernando, additional, Zaro, Tiziana, additional, Nazzaro, Marco, additional, Rao, Sunil V., additional, van‘t Hof, Arnoud W.J., additional, Omerovic, Elmir, additional, Campo, Gianluca, additional, Uguccioni, Lucia, additional, Tamburino, Corrado, additional, Zavalloni-Parenti, Dennis, additional, Ceravolo, Roberto, additional, Pasquetto, Giampaolo, additional, Mameli, Stefano, additional, Stochino, Maria Letizia, additional, Cremonesi, Alberto, additional, abate, Fabio, additional, Picchi, Andrea, additional, Colangelo, Salvatore, additional, Boccuzzi, Giacomo, additional, Varbella, Ferdinando, additional, Tresoldi, Stefano, additional, Contarini, Marco, additional, Evola, Rosario, additional, Creaco, Manuela, additional, Colombo, Antonio, additional, Chieffo, Alaide, additional, Sciahbasi, Alessandro, additional, Pucci, Edoardo, additional, Romagnoli, Enrico, additional, Moretti, Claudio, additional, Moretti, Luciano, additional, Zimmarino, Marco, additional, Ferrario, Maurizio, additional, Turturo, Maurizio, additional, Bonmassari, Roberto, additional, Penzo, Carlo, additional, Mauro, Ciro, additional, Petronio, Anna Sonia, additional, Gabrielli, Gabriele, additional, Amico, Francesco, additional, Comeglio, Marco, additional, Fresco, Claudio, additional, Van Mieghem, Nicolas, additional, Diletti, Roberto, additional, Regar, Evelyn, additional, Sabaté, Manel, additional, Gómez Hospital, Joan Antoni, additional, Díaz Fernández, José Francisco, additional, and Mainar, Vicente, additional

Published
2017
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19. Update of the position document of the Italian Society of Interventional Cardiology (SICI-GISE) on the minimum requirements for hospitals and operators performing procedures of a transcatheter implantation of aortic valve prostheses

Author

Tarantini, G., Esposito, G., Musumeci, G., Fraccaro, C., Franzone, A., Castiglioni, B., La Manna, A., Limbruno, U., Marchese, A., Mauro, C., Rigattieri, S., Tarantino, F., Gandolfo, C., Santoro, G., Violini, R., Airoldi, F., Albiero, R., Balbi, M., Baralis, G., Bartorelli, A.L., Bedogni, F., Benassi, A., Berni, A., Bonzani, G., Bortone, A.S., Braito, G., Briguori, C., Brscic, E., Calabrò, P., Calchera, I., Bigazzi, M.C., Caprioglio, F., Castriota, F., Cernetti, C., Cicala, C., Cioffi, P., Colombo, A., Colombo, V., Contegiacomo, G., Cremonesi, A., D'Amico, M., De Benedictis, M., De Leo, A., Di Biasi, M., Di Girolamo, D., Di Lorenzo, E., Di Mario, C., Dominici, M., Ettori, F., Ferrario, M., Fioranelli, M., Fischetti, D., Gabrielli, G., Giordano, A., Giudice, P., Greco, C., Indolfi, C., Leonzi, O., Lettieri, C., Loi, B., Maddestra, N., Marchionni, N., Marrozzini, C., Medda, M., Missiroli, B., Luigi, M., Oreglia, J.A., Palmieri, C., Pantaleo, P., Paparoni, S.R., Parodi, G., Petronio, A.S., Piatti, L., Piccaluga, E., Pierli, C., Perkan, A., Pitì, A., Poli, A., Ramondo, A.B., Reale, M.A., Reimers, B., Ribichini, F.L., Rosso, R., Saccà, S., Sacra, C., Santarelli, A., Sardella, G., Satullo, G., Scalise, F., Siviglia, M., Spedicato, L., Stabile, A., Tamburino, C., Tesorio, T.N.M., Tolaro, S., Tomai, F., Trani, C., Valenti, R., Valsecchi, O., Valva, G., Varbella, F., Vigna, C., Vignali, L., Berti, S., Tarantini, Giuseppe, Esposito, Giovanni, Musumeci, Giuseppe, Fraccaro, Chiara, Franzone, Anna, Castiglioni, Battistina, La Manna, Alessio, Limbruno, Ugo, Marchese, Alfredo, Mauro, Ciro, Rigattieri, Stefano, Tarantino, Fabio, Gandolfo, Caterina, Santoro, Gennaro, Violini, Roberto, Airoldi, Flavio, Albiero, Remo, Balbi, Manrico, Baralis, Giorgio, Bartorelli, Antonio Luca, Bedogni, Francesco, Benassi, Alberto, Berni, Andrea, Bonzani, Giulio, Bortone, Alessandro Santo, Braito, Giuseppe, Briguori, Carlo, Brscic, Elvi, Calabrò, Paolo, Calchera, Ivan, Cappelli Bigazzi, Maurizio, Caprioglio, Francesco, Castriota, Fausto, Cernetti, Carlo, Cicala, Cinzia, Cioffi, Paolo, Colombo, Antonio, Colombo, Virgilio, Contegiacomo, Gaetano, Cremonesi, Alberto, D'Amico, Maurizio, De Benedictis, Mauro, De Leo, Alessandro, Di Biasi, Maurizio, Di Girolamo, Domenico, Di Lorenzo, Emilio, Di Mario, Carlo, Dominici, Marcello, Ettori, Federica, Ferrario, Maurizio, Fioranelli, Massimo, Fischetti, Dionigi, Gabrielli, Gabriele, Giordano, Arturo, Giudice, Pietro, Greco, Cesare, Indolfi, Ciro, Leonzi, Ornella, Lettieri, Corrado, Loi, Bruno, Maddestra, Nicola, Marchionni, Niccolò, Marrozzini, Cinzia, Medda, Massimo, Missiroli, Bindo, Luigi, My, Oreglia, Jacopo Andrea, Palmieri, Cataldo, Pantaleo, Paolo, Paparoni, Saro Roberto, Parodi, Guido, Petronio, Anna Sonia, Piatti, Luigi, Piccaluga, Emanuela, Pierli, Carlo, Perkan, Andrea, Pitì, Antonino, Poli, Arnaldo, Ramondo, Angelo Bruno, Reale, Maurizio Alessandro, Reimers, Bernhard, Ribichini, Flavio Luciano, Rosso, Roberta, Saccà, Salvatore, Sacra, Cosimo, Santarelli, Andrea, Sardella, Gennaro, Satullo, Gaetano, Scalise, Filippo, Siviglia, Massimo, Spedicato, Leonardo, Stabile, Amerigo, Tamburino, Corrado, Tesorio, Tullio Nicola Maria, Tolaro, Salvatore, Tomai, Fabrizio, Trani, Carlo, Valenti, Renato, Valsecchi, Orazio, Valva, Giuseppe, Varbella, Ferdinando, Vigna, Carlo, Vignali, Luigi, and Berti, Sergio

Subjects
Transcatheter aortic valve implantation, Institutions, Operators, Requirements, Training, Cardiology and Cardiovascular Medicine, Requirement, Institution, Operator, Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Abstract

Transcatheter aortic valve implantation (TAVI) has revolutionized the management of patients with symptomatic severe aortic stenosis and has become the standard of care for inoperable patients and the preferred therapy for those at increased surgical risk with peculiar clinical and anatomic features. Technology advances, growing experience and accumulating data prompted the update of the 2011 Italian Society of Interventional Cardiology (SICI-GISE) position paper on institutional and operator requirements to perform TAVI. The main objective of this document is to provide a guidance to assess the potential of institutions and operators to initiate and maintain an efficient TAVI program. Transcatheter aortic valve implantation (TAVI) has revolutionized the management of patients with symptomatic severe aortic stenosis and has become the standard of care for inoperable patients and the preferred therapy for those at increased surgical risk with peculiar clinical and anatomic features. Technology advances, growing experience and accumulating data prompted the update of the 2011 Italian Society of Interventional Cardiology (SICI-GISE) position paper on institutional and operator requirements to perform TAVI. The main objective of this document is to provide a guidance to assess the potential of institutions and operators to initiate and maintain an efficient TAVI program.

Published
2018

20. Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial

Author

Marco Valgimigli, Enrico Frigoli, Sergio Leonardi, Pascal Vranckx, Martina Rothenbühler, Matteo Tebaldi, Ferdinando Varbella, Paolo Calabrò, Stefano Garducci, Paolo Rubartelli, Carlo Briguori, Giuseppe Andó, Maurizio Ferrario, Ugo Limbruno, Roberto Garbo, Paolo Sganzerla, Filippo Russo, Marco Nazzaro, Alessandro Lupi, Bernardo Cortese, Arturo Ausiello, Salvatore Ierna, Giovanni Esposito, Giuseppe Ferrante, Andrea Santarelli, Gennaro Sardella, Nicoletta de Cesare, Paolo Tosi, Arnoud van 't Hof, Elmir Omerovic, Salvatore Brugaletta, Stephan Windecker, Dik Heg, Peter Jüni, Gianluca Campo, Lucia Uguccioni, Corrado Tamburino, Patrizia Presbitero, Dennis Zavalloni-Parenti, Fabio Ferrari, Roberto Ceravolo, Fabio Tarantino, Giampaolo Pasquetto, Gavino Casu, Stefano Mameli, Maria Letizia Stochino, Pietro Mazzarotto, Alberto Cremonesi, Francesco Saia, Giovanni Saccone, Fabio Abate, Andrea Picchi, Roberto Violini, Salvatore Colangelo, Giacomo Boccuzzi, Vincenzo Guiducci, Carlo Vigna, Antonio Zingarelli, Andrea Gagnor, Tiziana Zaro, Simone Tresoldi, Pietro Vandoni, Marco Contarini, Armando Liso, Antonio Dellavalle, Salvatore Curello, Fabio Mangiacapra, Rosario Evola, Cataldo Palmieri, Camillo Falcone, Francesco Liistro, Manuela Creaco, Antonio Colombo, Alaide Chieffo, Andrea Perkan, Stefano De Servi, Dionigi Fischetti, Stefano Rigattieri, Alessandro Sciahbasi, Edoardo Pucci, Enrico Romagnoli, Claudio Moretti, Luciano Moretti, Raffaele De Caterina, Marcello Caputo, Marco Zimmarino, Ezio Bramucci, Emilio Di Lorenzo, Maurizio Turturo, Roberto Bonmassari, Carlo Penzo, Bruno Loi, Ciro Mauro, Anna Sonia Petronio, Gabriele Gabrielli, Antonio Micari, Flavia Belloni, Francesco Amico, Marco Comeglio, Claudio Fresco, Isala Klinieken, Nicolas Van Mieghem, Roberto Diletti, Evelyn Regar, Manel Sabaté, Joan Antoni Gómez Hospital, José Francisco Díaz Fernández, Vicente Mainar, Jose Maria de la Torre Hernandez, Valgimigli, Marco, Frigoli, Enrico, Leonardi, Sergio, Vranckx, Pascal, Rothenbühler, Martina, Tebaldi, Matteo, Varbella, Ferdinando, Calabrò, Paolo, Garducci, Stefano, Rubartelli, Paolo, Briguori, Carlo, Andó, Giuseppe, Ferrario, Maurizio, Limbruno, Ugo, Garbo, Roberto, Sganzerla, Paolo, Russo, Filippo, Nazzaro, Marco, Lupi, Alessandro, Cortese, Bernardo, Ausiello, Arturo, Ierna, Salvatore, Esposito, Giovanni, Ferrante, Giuseppe, Santarelli, Andrea, Sardella, Gennaro, de Cesare, Nicoletta, Tosi, Paolo, van 't Hof, Arnoud, Omerovic, Elmir, Brugaletta, Salvatore, Windecker, Stephan, Heg, Dik, Jüni, Peter, Cardiologie, RS: CARIM - R2.01 - Clinical atrial fibrillation, MUMC+: MA Med Staf Spec Cardiologie (9), Campo, Gianluca, Uguccioni, Lucia, Tamburino, Corrado, Presbitero, Patrizia, Zavalloni-Parenti, Denni, Ferrari, Fabio, Ceravolo, Roberto, Tarantino, Fabio, Pasquetto, Giampaolo, Casu, Gavino, Mameli, Stefano, Stochino, Maria Letizia, Mazzarotto, Pietro, Cremonesi, Alberto, Saia, Francesco, Saccone, Giovanni, Abate, Fabio, Picchi, Andrea, Violini, Roberto, Colangelo, Salvatore, Boccuzzi, Giacomo, Guiducci, Vincenzo, Vigna, Carlo, Zingarelli, Antonio, Gagnor, Andrea, Zaro, Tiziana, Tresoldi, Simone, Vandoni, Pietro, Contarini, Marco, Liso, Armando, Dellavalle, Antonio, Curello, Salvatore, Mangiacapra, Fabio, Evola, Rosario, Palmieri, Cataldo, Falcone, Camillo, Liistro, Francesco, Creaco, Manuela, Colombo, Antonio, Chieffo, Alaide, Perkan, Andrea, De Servi, Stefano, Fischetti, Dionigi, Rigattieri, Stefano, Sciahbasi, Alessandro, Pucci, Edoardo, Romagnoli, Enrico, Moretti, Claudio, Moretti, Luciano, De Caterina, Raffaele, Caputo, Marcello, Zimmarino, Marco, Bramucci, Ezio, Di Lorenzo, Emilio, Turturo, Maurizio, Bonmassari, Roberto, Penzo, Carlo, Loi, Bruno, Mauro, Ciro, Petronio, Anna Sonia, Gabrielli, Gabriele, Micari, Antonio, Belloni, Flavia, Amico, Francesco, Comeglio, Marco, Fresco, Claudio, Klinieken, Isala, Van Mieghem, Nicola, Diletti, Roberto, Regar, Evelyn, Sabaté, Manel, Gómez Hospital, Joan Antoni, Díaz Fernández, José Francisco, Mainar, Vicente, and de la Torre Hernandez, Jose Maria

Subjects
Male, Prasugrel, medicine.medical_treatment, MONOTHERAPY, Myocardial Infarction, 030204 cardiovascular system & hematology, Coronary Angiography, ANGIOGRAPHY, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Bivalirudin, ARTERY-DISEASE, 030212 general & internal medicine, Myocardial infarction, 610 Medicine & health, Medicine (all), SITE, 2017 ESC, PCI, General Medicine, Hirudins, Middle Aged, Clopidogrel, Recombinant Proteins, Prosthesis Failure, Stroke, Femoral Artery, Acute Coronary Syndrome, Aged, Anticoagulants, Antithrombins, Female, Hemorrhage, Heparin, Humans, Mortality, Peptide Fragments, Percutaneous Coronary Intervention, Perioperative Care, Platelet Glycoprotein GPIIb-IIIa Complex, Stents, Radial Artery, Cardiology, Ticagrelor, INTERVENTION, medicine.drug, Acute coronary syndrome, medicine.medical_specialty, ACUTE MYOCARDIAL-INFARCTION, 03 medical and health sciences, Internal medicine, medicine, METAANALYSIS, business.industry, Percutaneous coronary intervention, medicine.disease, business
Abstract

Summary Background The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox (MATRIX) programme was designed to assess the comparative safety and effectiveness of radial versus femoral access and of bivalirudin versus unfractionated heparin with optional glycoprotein IIb/IIIa inhibitors in patients with the whole spectrum of acute coronary syndrome undergoing invasive management. Here we describe the prespecified final 1-year outcomes of the entire programme. Methods MATRIX was a programme of three nested, randomised, multicentre, open-label, superiority trials in patients with acute coronary syndrome in 78 hospitals in Italy, the Netherlands, Spain, and Sweden. Patients with ST-elevation myocardial infarction were simultaneously randomly assigned (1:1) before coronary angiography to radial or femoral access and to bivalirudin, with or without post-percutaneous coronary intervention infusion or unfractionated heparin (one-step inclusion). Patients with non-ST-elevation acute coronary syndrome were randomly assigned (1:1) before coronary angiography to radial or femoral access and, only if deemed eligible to percutaneous coronary intervention after angiography (two-step inclusion), entered the antithrombin type and treatment duration programmes. Randomisation sequences were computer generated, blocked, and stratified by intended new or current use of P2Y12 inhibitor (clopidogrel vs ticagrelor or prasugrel), and acute coronary syndrome type (ST-elevation myocardial infarction, troponin-positive, or troponin-negative non-ST-elevation acute coronary syndrome). Bivalirudin was given as a bolus of 0·75 mg/kg, followed immediately by an infusion of 1·75 mg/kg per h until completion of percutaneous coronary intervention. Heparin was given at 70–100 units per kg in patients not receiving glycoprotein IIb/IIIa inhibitors, and at 50–70 units per kg in patients receiving glycoprotein IIb/IIIa inhibitors. Clinical follow-up was done at 30 days and 1 year. Co-primary outcomes for MATRIX access and MATRIX antithrombin type were major adverse cardiovascular events, defined as the composite of all-cause mortality, myocardial infarction, or stroke up to 30 days; and net adverse clinical events, defined as the composite of non-coronary artery bypass graft-related major bleeding, or major adverse cardiovascular events up to 30 days. The primary outcome for MATRIX treatment duration was the composite of urgent target vessel revascularisation, definite stent thrombosis, or net adverse clinical events up to 30 days. Analyses were done according to the intention-to-treat principle. This trial is registered with ClinicalTrials.gov, number NCT01433627. Findings Between Oct 11, 2011, and Nov 7, 2014, we randomly assigned 8404 patients to receive radial (4197 patients) or femoral (4207 patients) access. Of these 8404 patients, 7213 were included in the MATRIX antithrombin type study and were randomly assigned to bivalirudin (3610 patients) or heparin (3603 patients). Patients assigned to bivalirudin were included in the MATRIX treatment duration study, and were randomly assigned to post-procedure infusion (1799 patients) or no post-procedure infusion (1811 patients). At 1 year, major adverse cardiovascular events did not differ between patients assigned to radial access compared with those assigned to femoral access (14·2% vs 15·7%; rate ratio 0·89, 95% CI 0·80–1·00; p=0·0526), but net adverse clinical events were fewer with radial than with femoral access (15·2% vs 17·2%; 0·87, 0·78–0·97; p=0·0128). Compared with heparin, bivalirudin was not associated with fewer major adverse cardiovascular (15·8% vs 16·8%; 0·94, 0·83–1·05; p=0·28) or net adverse clinical events (17·0% vs 18·4%; 0·91, 0·81–1·02; p=0·10). The composite of urgent target vessel revascularisation, stent thrombosis, or net adverse clinical events did not differ with or without post-procedure bivalirudin infusion (17·4% vs 17·4%; 0·99, 0·84–1·16; p=0·90). Interpretation In patients with acute coronary syndrome, radial access was associated with lower rates of net adverse clinical events compared with femoral access, but not major adverse cardiovascular events at 1 year. Bivalirudin with or without post-procedure infusion was not associated with lower rates of major adverse cardiovascular events or net adverse clinical events. Radial access should become the default approach in acute coronary syndrome patients undergoing invasive management. Funding Italian Society of Invasive Cardiology, The Medicines Company, Terumo, amd Canada Research Chairs Programme.

Published
2018

21. Management of Patients Treated With Oral Anticoagulant Therapy Undergoing Percutaneous Coronary Intervention With Stent Implantation: The PERSEO Registry.

Author

Sciahbasi A, De Rosa S, Gargiulo G, Giacoppo D, Calabrò P, Talarico GP, Zilio F, Talanas G, Tebaldi M, Andò G, Rigattieri S, Misuraca L, Cortese B, Musuraca G, Lucci V, Guiducci V, Renda G, Zezza L, Versaci F, Giannico MB, Caruso M, Fischetti D, Colletta M, Santarelli A, Larosa C, Iannone A, Esposito G, Tarantini G, Musumeci G, and Rubboli A

Subjects
Humans, Male, Female, Aged, Administration, Oral, Prospective Studies, Treatment Outcome, Middle Aged, Risk Factors, Time Factors, Aged, 80 and over, Coronary Artery Disease therapy, Risk Assessment, Fibrinolytic Agents administration & dosage, Fibrinolytic Agents adverse effects, Platelet Aggregation Inhibitors adverse effects, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors therapeutic use, Registries, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention instrumentation, Hemorrhage chemically induced, Stents, Anticoagulants adverse effects, Anticoagulants administration & dosage, Anticoagulants therapeutic use
Abstract

Abstract: In patients on oral anticoagulant (OAC) therapy undergoing percutaneous coronary intervention (PCI) with stent, international guidelines endorse the use of direct oral anticoagulants (DOAC) rather than vitamin K antagonists (VKA) and dual antithrombotic therapy (DAT) rather than triple antithrombotic therapy (TAT). The aim of this study was to evaluate contemporary real-world data on antithrombotic regimens and outcome in patients on OAC undergoing PCI with stent. Consecutive patients on OAC undergoing PCI were enrolled in the multicenter, prospective, observational PERSEO registry (NCT03392948). Primary end point was net adverse clinical events (NACE) with VKA versus DOAC, whereas a secondary prespecified end point was NACE with DAT versus TAT both at 1-year follow-up. From February 2018 to February 2022; in total, 1234 consecutive patients were included. The main indication for OAC was atrial fibrillation (86%), and the mean CHA 2 DS 2 VASc and HAS-BLED scores were 4 ± 2 and 3.6 ± 1, respectively. Of the 1228 patients discharged alive, 222 (18%) were on VKA and 1006 (82%) on DOAC ( P < 0.01). DAT was employed in 197 patients whereas TAT in 1028. At follow-up, NACE rate was significantly higher than VKA compared with DOAC (23% vs. 16%, P = 0.013) and confirmed after propensity score adjustment. TAT and DAT did not differ as regards NACE rate (17% vs. 19%, P = 0.864) although, compared with TAT, DAT was associated with less major bleedings (2% vs. 5%, P = 0.014), confirmed after propensity score adjustment. In conclusion, in patients on OAC undergoing PCI, DOAC, compared with VKA, was associated with a significantly lower occurrence of NACE and DAT reduced bleedings compared with TAT., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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22. [Updated SICI-GISE position paper on institutional and operator requirements for transcatheter aortic valve implantation].

Author

Tarantini G, Esposito G, Musumeci G, Fraccaro C, Franzone A, Castiglioni B, La Manna A, Limbruno U, Marchese A, Mauro C, Rigattieri S, Tarantino F, Gandolfo C, Santoro G, Violini R, Airoldi F, Albiero R, Balbi M, Baralis G, Bartorelli AL, Bedogni F, Benassi A, Berni A, Bonzani G, Bortone AS, Braito G, Briguori C, Brscic E, Calabrò P, Calchera I, Cappelli Bigazzi M, Caprioglio F, Castriota F, Cernetti C, Cicala C, Cioffi P, Colombo A, Colombo V, Contegiacomo G, Cremonesi A, D'Amico M, De Benedictis M, De Leo A, Di Biasi M, Di Girolamo D, Di Lorenzo E, Di Mario C, Dominici M, Ettori F, Ferrario M, Fioranelli M, Fischetti D, Gabrielli G, Giordano A, Giudice P, Greco C, Indolfi C, Leonzi O, Lettieri C, Loi B, Maddestra N, Marchionni N, Marrozzini C, Medda M, Missiroli B, My L, Oreglia JA, Palmieri C, Pantaleo P, Paparoni SR, Parodi G, Petronio AS, Piatti L, Piccaluga E, Pierli C, Perkan A, Pitì A, Poli A, Ramondo AB, Reale MA, Reimers B, Ribichini FL, Rosso R, Saccà S, Sacra C, Santarelli A, Sardella G, Satullo G, Scalise F, Siviglia M, Spedicato L, Stabile A, Tamburino C, Tesorio TNM, Tolaro S, Tomai F, Trani C, Valenti R, Valsecchi O, Valva G, Varbella F, Vigna C, Vignali L, and Berti S

Subjects
Aortic Valve Stenosis physiopathology, Biomedical Technology trends, Humans, Italy, Severity of Illness Index, Transcatheter Aortic Valve Replacement instrumentation, Aortic Valve Stenosis surgery, Program Development methods, Transcatheter Aortic Valve Replacement methods
Abstract

Transcatheter aortic valve implantation (TAVI) has revolutionized the management of patients with symptomatic severe aortic stenosis and has become the standard of care for inoperable patients and the preferred therapy for those at increased surgical risk with peculiar clinical and anatomic features. Technology advances, growing experience and accumulating data prompted the update of the 2011 Italian Society of Interventional Cardiology (SICI-GISE) position paper on institutional and operator requirements to perform TAVI. The main objective of this document is to provide a guidance to assess the potential of institutions and operators to initiate and maintain an efficient TAVI program.

Published
2018
Full Text
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