Author: "Fischer MJ" - Searchworks@Jio Institute Digital Library Search Results

320 results on '"Fischer MJ"'

1. Female Patients Show a Larger Reduction in Suicidal Ideation in Inpatient Addiction Treatment Than Male Patients: Results of a Single-Center Observational Study

Author: Grote V, Wagner T, Riedl D, Kautzky-Willer A, Fischer MJ, Scheibenbogen O, and Musalek M
Subjects: addiction, inpatient therapy, alcohol, drugs, gender medicine, Public aspects of medicine, RA1-1270
Abstract: Vincent Grote,1,&ast; Tim Wagner,1,2,&ast; David Riedl,1,3 Alexandra Kautzky-Willer,4 Michael J Fischer,1,5,6 Oliver Scheibenbogen,2 Michael Musalek7– 9 1Ludwig Boltzmann Institute for Rehabilitation Research, Ludwig Boltzmann Gesellschaft, Vienna, Austria; 2Anton Proksch Institute, Vienna, Austria; 3University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria; 4Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria; 5Vamed Rehabilitation Center Kitzbühel, Kitzbühel, Austria; 6Clinic for Rehabilitation Medicine, Hannover Medical School MHH, Hannover, Germany; 7Department of General Psychiatry, Sigmund Freud University, Vienna, Austria; 8Institute for Social Aesthetics and Mental Health, Sigmund Freud University, Vienna, Austria; 9Institute for Social Aesthetics and Mental Health, Sigmund Freud University, Berlin, Germany&ast;These authors contributed equally to this workCorrespondence: Vincent Grote; Oliver Scheibenbogen, Email vincent.grote@rehabilitation.lbg.ac.at; oliver.scheibenbogen@api.or.atBackground: Substance use disorders (SUD) are prevalent disorders worldwide. Among other associated health problems, patients with SUD are at an increased risk of dying of suicide, with females displaying an even higher risk than males. Therefore, the aim of this study was to conduct a gender-sensitive evaluation of changes in suicidal ideation during multimodal inpatient treatment at a hospital facility specialized in treating addiction.Methods: A total of 694 patients (68.2% male) completed routine assessment including suicidal ideation, abstinence confidence, impulsivity, emotion regulation, self-efficacy and autonomy and joy both before (T1) and at the end (T2) of treatment. Mean changes were evaluated with repeated measures MANOVAs.Results: Before treatment, a total of n=127 (18.3%) of the respondents reported suicidal ideation, which was reduced to n=72 (10.4%) by the end of treatment. Among female patients, the change in reported suicidal ideation compared from T1 to T2 (21.7% vs 7.7%) was significantly higher than among male patients (T1: 16.7%%, T2: 11.6%; p=0.040). Generally, females reported worse symptoms scores and slightly higher numbers of suicidal thoughts at baseline (effect sizes ranging from η²=.008 – 0.044). While both genders significantly profited from the treatment, female patients generally showed larger improvements than male.Discussion: Our study underscores the beneficial effect of addiction-specialized inpatient treatment on suicidal ideation. Additionally, we found a substantial gender effect: while female patients generally were more distressed before treatment, they also reported higher symptom reduction during the treatment. This result highlights the need to perform more gender-sensitive research and develop more gender-sensitive treatment programs.Keywords: addiction, inpatient therapy, alcohol, drugs, gender medicine
Published: 2024

2. Illness Perceptions and Quality of Life in Patients with Non-Small-Cell Lung Cancer: A 3-Month Follow-Up Pilot Study

Author: Vollmann M, Matsuda A, Kroep JR, Kobayashi K, Kubota K, Inoue K, Yamaoka K, Putter H, Ramai R, Nortier JWR, Fischer MJ, and Kaptein AA
Subjects: lung cancer, illness perceptions, quality of life, longitudinal design, patient reported outcomes, Medicine (General), R5-920
Abstract: Manja Vollmann,1 Ayako Matsuda,2 Judith R Kroep,3 Kunihiko Kobayashi,4 Kaoru Kubota,5 Kenichi Inoue,6 Kazue Yamaoka,7 Hein Putter,8 Rajen Ramai,9 Johannes WR Nortier,3 Maarten J Fischer,10 Ad A Kaptein10 1Socio-Medical Sciences ESHPM, Erasmus University Rotterdam, Rotterdam, the Netherlands; 2Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan; 3Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; 4Saitama International Medical Center Saitama, Saitama, Japan; 5Nippon Medical School Hospital, Tokyo, Japan; 6Saitama Cancer Center, Saitama, Japan; 7Teikyo University Graduate School of Public Health, Tokyo, Japan; 8Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands; 9Respiratory Medicine, Leiden University Medical Centre, Leiden, the Netherlands; 10Medical Psychology, Leiden University Medical Center, Leiden, the NetherlandsCorrespondence: Ad A KapteinDepartment of Medical Psychology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, the NetherlandsEmail a.a.kaptein@lumc.nlPurpose: Examine illness perceptions, functional health and quality of life of lung cancer patients throughout chemotherapy treatment.Patients and Methods: Longitudinal design with baseline measure 12 days after the first chemotherapy and follow-up measure 3 months later, where illness perceptions (BIPQ), functional health, and quality of life (EORTC QLQ-C-30) were measured. A total of 21 patients with non-small-cell lung cancer took part. Non-parametric testing was performed given the pilot nature of the study and the associated relatively small sample size.Results: Small to medium changes in illness perceptions and functional health between the two measurement points were detected, with both becoming more positive. More negative illness perceptions at the beginning of the treatment were associated with less functioning and lower quality of life at both beginning and end of treatment.Conclusion: Addressing illness perceptions seems a clinically relevant approach in improving functioning and quality of life of patients with non-small-cell lung cancer.Keywords: lung cancer, illness perceptions, quality of life, longitudinal design, patient reported outcomes
Published: 2020

3. Self-management in patients with COPD: theoretical context, content, outcomes, and integration into clinical care

Author: Kaptein AA, Fischer MJ, and Scharloo M
Subjects: Diseases of the respiratory system, RC705-779
Abstract: Ad A Kaptein, Maarten J Fischer, Margreet Scharloo Medical Psychology Section, Leiden University Medical Centre (LUMC), Leiden, the Netherlands Abstract: In this narrative review, we put self-management in the context of a 50-year history of research about how patients with COPD respond to their illness. We review a definition of self-management, and emphasize that self-management should be combined with disease management and the chronic care model in order to be effective. Reviewing the empirical status of self-management in COPD, we conclude that self-management is part and parcel of modern, patient-oriented biopsychosocial care. In pulmonary rehabilitation programs, self-management is instrumental in improving patients’ functional status and quality of life. We conclude by emphasizing how studying the way persons with COPD make sense of their illness helps in refining self-management, and thereby patient-reported outcomes in COPD. Keywords: chronic obstructive pulmonary disease, self-management, psychology, quality of life, biopsychosocial model, medical humanities
Published: 2014

4. Risk of End‐Stage Renal Disease in HIV‐Positive Potential Live Kidney Donors

Author: Muzaale, AD, Althoff, KN, Sperati, CJ, Abraham, AG, Kucirka, LM, Massie, AB, Kitahata, MM, Horberg, MA, Justice, AC, Fischer, MJ, Silverberg, MJ, Butt, AA, Boswell, SL, Rachlis, AR, Mayor, AM, Gill, MJ, Eron, JJ, Napravnik, S, Drozd, DR, Martin, JN, Bosch, RJ, Durand, CM, Locke, JE, Moore, RD, Lucas, GM, and Segev, DL
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, HIV/AIDS, Infectious Diseases, Sexually Transmitted Infections, Kidney Disease, Aetiology, 2.2 Factors relating to the physical environment, Renal and urogenital, Infection, Good Health and Well Being, Adult, Case-Control Studies, Female, Follow-Up Studies, Glomerular Filtration Rate, Graft Rejection, Graft Survival, HIV Infections, HIV Seropositivity, HIV-1, Humans, Incidence, Kidney Failure, Chronic, Kidney Function Tests, Kidney Transplantation, Living Donors, Male, Middle Aged, Nephrectomy, North America, Prognosis, Risk Factors, Viral Load, clinical research/practice, donors and donation: living, infection and infectious agents, infectious disease, kidney transplantation/nephrology, viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome, Medical and Health Sciences, Surgery, Clinical sciences, Immunology
Abstract: New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years. We used risk associations from multivariable Cox proportional hazards regression to derive cumulative incidence estimates for selected HIV-positive scenarios (no history of diabetes, hypertension, AIDS, or hepatitis C virus coinfection) and compared these estimates with those from similarly selected HIV-negative scenarios. For 40-year-old HIV-positive individuals with health characteristics that were similar to those of age-matched kidney donors, viral load
Published: 2017

5. Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study

Author: Mehta, NN, Matthews, GJ, Krishnamoorthy, P, Shah, R, McLaughlin, C, Patel, P, Budoff, M, Chen, J, Wolman, M, Go, A, He, J, Kanetsky, PA, Master, SR, Rader, DJ, Raj, D, Gadegbeku, CA, Schreiber, M, Fischer, MJ, Townsend, RR, Kusek, J, Feldman, HI, Foulkes, AS, Reilly, MP, Appel, LJ, Go, AS, Kusek, JW, Lash, JP, Ojo, A, and Rahman, M
Subjects: Kidney Disease, Cardiovascular, Heart Disease - Coronary Heart Disease, Prevention, Aging, Heart Disease, Renal and urogenital, Good Health and Well Being, Adult, Aged, Biomarkers, Chemokine CXCL12, Cross-Sectional Studies, Female, Humans, Incidental Findings, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Renal Insufficiency, Chronic, Young Adult, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Atherosclerosis, CXCL12, Chemokines, Myocardial infarction, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract: AimsGenome-wide association studies revealed an association between a locus at 10q11, downstream from CXCL12, and myocardial infarction (MI). However, the relationship among plasma CXCL12, cardiovascular disease (CVD) risk factors, incident MI, and death is unknown.Methods and resultsWe analysed study-entry plasma CXCL12 levels in 3687 participants of the Chronic Renal Insufficiency Cohort (CRIC) Study, a prospective study of cardiovascular and kidney outcomes in chronic kidney disease (CKD) patients. Mean follow-up was 6 years for incident MI or death. Plasma CXCL12 levels were positively associated with several cardiovascular risk factors (age, hypertension, diabetes, hypercholesterolaemia), lower estimated glomerular filtration rate (eGFR), and higher inflammatory cytokine levels (P < 0.05). In fully adjusted models, higher study-entry CXCL12 was associated with increased odds of prevalent CVD (OR 1.23; 95% confidence interval 1.14, 1.33, P < 0.001) for one standard deviation (SD) increase in CXCL12. Similarly, one SD higher CXCL12 increased the hazard of incident MI (1.26; 1.09,1.45, P < 0.001), death (1.20; 1.09,1.33, P < 0.001), and combined MI/death (1.23; 1.13-1.34, P < 0.001) adjusting for demographic factors, known CVD risk factors, and inflammatory markers and remained significant for MI (1.19; 1.03,1.39, P = 0.01) and the combined MI/death (1.13; 1.03,1.24, P = 0.01) after further controlling for eGFR and urinary albumin:creatinine ratio.ConclusionsIn CKD, higher plasma CXCL12 was associated with CVD risk factors and prevalent CVD as well as the hazard of incident MI and death. Further studies are required to establish if plasma CXCL12 reflect causal actions at the vessel wall and is a tool for genomic and therapeutic trials.
Published: 2014

6. Human immunocompetent choroid-on-chip: A novel tool for studying ocular effects of biological drugs

Author: Schluender K, M. Mesquida, Lena Mesch, Christopher Probst, Stefan Liebau, Fischer Mj, Magdalene Weiss, Anneliese Schneider, Peter Loskill, Stefan Kustermann, Nicolini, Madalena Cipriano, Kevin Achberger, Linke K, Giusti Am, and Publica
Subjects: Stromal cell, QH301-705.5, CD3, medicine.medical_treatment, Article, chemistry.chemical_compound, Immune system, Antibodies, Bispecific, Microchip Analytical Procedures, medicine, Humans, Biology (General), Drug safety, Eye diseases, Inflammation, Biological Products, biology, business.industry, Choroid, Endothelial Cells, Retinal, biochemical phenomena, metabolism, and nutrition, medicine.anatomical_structure, Cytokine, chemistry, Cancer research, biology.protein, Imaging the immune system, Melanocytes, bacteria, sense organs, Antibody, Immunocompetence, business
Abstract: Disorders of the eye leading to visual impairment are a major issue that affects millions of people. On the other side ocular toxicities were described for e.g. molecularly targeted therapies in oncology and may hamper their development. Current ocular model systems feature a number of limitations affecting human-relevance and availability. To find new options for pharmacological treatment and assess mechanisms of toxicity, hence, novel complex model systems that are human-relevant and readily available are urgently required. Here, we report the development of a human immunocompetent Choroid-on-Chip (CoC), a human cell-based in vitro model of the choroid layer of the eye integrating melanocytes and microvascular endothelial cells, covered by a layer of retinal pigmented epithelial cells. Immunocompetence is achieved by perfusion of peripheral immune cells. We demonstrate controlled immune cell recruitment into the stromal compartments through a vascular monolayer and in vivo-like cytokine release profiles. To investigate applicability for both efficacy testing of immunosuppressive compounds as well as safety profiling of immunoactivating antibodies, we exposed the CoCs to cyclosporine and tested CD3 bispecific antibodies., To address the key physiological characteristics related to choroidal drug reactions and its immunology, Cipriano et al. developed a human immunocompetent choroidal in vitro model that mimics the tissue vascularization, pigmentation and immune response in the presence of circulating immune cells. This could help building a toolbox of in vitro models recapitulating aspects of the immune system to study immuneoncology.
Published: 2022

7. LPA, aber nicht Gallensalze aktivieren humane sensorische Neurone und induzieren Jucken

Author: Kremer, AE, additional, Düll, M, additional, Wurm, L, additional, Ries, V, additional, Stengel, M, additional, Reeh, PW, additional, Fischer, MJ, additional, and Namer, B, additional
Published: 2017
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8. Percutaneous treatment of carotid stenosis with protection system: Preliminary experience

Author: Lupattelli, T, Fischer, Mj, Scalera, Gb, Maselli, A, Mosca, S, Pozzilli, P, Verzini, F, Cao, P, and Lupattelli, . L.
Subjects: Aged, 80 and over, Male, Treatment Outcome, Intracranial Embolism, Feasibility Studies, Humans, Carotid Stenosis, Female, Stents, Middle Aged, Angioplasty, Balloon, Aged, Retrospective Studies
Abstract: To assess the feasibility, safety, and efficacy of carotid artery stenting with filter device.Between May 2001 and July 2002, a total of 96 consecutive patients (100 lesions) who presented with symptomatic70% diameter stenosis, asymptomatic90% diameter stenosis or post-endarterectomy as well as post-radiotherapy hemodynamically significant stenosis underwent carotid artery stenting with filter protection at our institute. The mean age of the patients was 72 (range 51-91). There were 22 female (23%), and 74 male (77%). Of the 96 patients, 62 patients (65%) did not filled the NASCET surgical criteria and 24 (26%) were classified as ASA 4. All the patients underwent pretreatment with antiplatelet agents. All procedures were performed with a standardized monitoring system by a multidisciplinary team. Filtration system for cerebral protection was consistently used. Outcome measures were procedural atheroembolic events, including all-stroke and death rates up to 30 days.A protection system type "TRAP" (Microvena, Italy) or a protection system type "EPIFILTER" (Boston Scientific, USA) were employed in 28% and 67% of cases, respectively. In the remaining 5% it was not possible to cross the stenosis with the filter. The stent placement was achieved in 95 of the procedures (95%). In 86% of cases a primary stenting technique was performed, with balloon pre-dilation of the lesion and subsequent stent advancement through the stenosis accounting for 9% of cases. At the time of protection system removal, 21 filter (21%) showed presence of macroscopic particles. We recorded 8 (8%) homolateral neurological events: two major strokes, one minor stroke and five TIAs (all the patients with TIA fully recovered within 2 hours). General complications (5%) included one lesion of the median nerve, two groin haematomas (one with disability for the patient, and one requiring surgery), one myocardial infarct and one lower limb ischaemia requiring surgical intervention. All major complications (4%) (two major strokes, one myocardial infarct and one lesion of the median nerve) occurred within the first 31 cases, the 69 following procedures not showing any neurological or non-neurological major events. At 30 days all patient were still alive.Filter protection during carotid artery stenting seems technically feasible as well as reasonably safe and effective. The EPIFILTER system turned out to be of easier employment due to its "monorail" system and because it does not usually need a catheter of dedicated recovery. Further studies in larger groups of patients are required to best characterize criteria guiding the choice for the right protection system.
Published: 2004

9. Abstract OT3-1-03: DIRECT: A phase II/III randomized trial with dietary restriction as an adjunct to neoadjuvant chemotherapy for HER2-negative breast cancer

Author: de Groot, S, primary, Vreeswijk, MPG, additional, Smit, VTHBM, additional, Heijns, JB, additional, Imholz, ALT, additional, Kessels, LW, additional, Jager, A, additional, Los, M, additional, Weijl, NI, additional, Smorenburg, CH, additional, Portielje, JEA, additional, Liefers, GJ, additional, van de Velde, CJH, additional, Meershoek, EM, additional, van Leeuwen, E, additional, Fischer, MJ, additional, Kaptein, AA, additional, Putter, H, additional, Longo, V, additional, Nortier, HWR, additional, van der Hoeven, KJM, additional, Pijl, H, additional, and Kroep, JR, additional
Published: 2013
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10. Understanding climate proxies in southwest-Australian speleothems

Author: Treble, Pauline C, primary, Fairchild, IJ, additional, and Fischer, MJ, additional
Published: 2008
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11. Manualmedizinische Behandlung bei Multi-Minicore Myopathie. Ein Fallbericht

Author: Fischer, MJ, primary, Reiners, A, additional, Smorag, U, additional, Küther, G, additional, Gutenbrunner, C, additional, and Gehrke, A, additional
Published: 2006
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12. Comparing VA and private sector healthcare costs for end-stage renal disease.

Author: Hynes DM, Stroupe KT, Fischer MJ, Reda DJ, Manning W, Browning MM, Huo Z, Saban K, Kaufman JS, and for ESRD Cost Study Group
Published: 2012
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13. Carboplatin plus pemetrexed for platinum-pretreated, advanced non-small cell lung cancer: a retrospective study with pharmacogenetic evaluation.

Author: Metro G, Chiari R, Mare M, Giannarelli D, Tofanetti FR, Minotti V, Ferraldeschi M, Giuffrida D, Marcomigni L, Bennati C, Fischer MJ, Meacci M, Bellavita R, Pistola L, Ludovini V, and Crinò L
Published: 2011

14. Predialysis nephrology care and costs in elderly patients initiating dialysis.

Author: Stroupe KT, Fischer MJ, Kaufman JS, O'Hare AM, Sohn MW, Browning MM, Huo Z, and Hynes DM
Published: 2011
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15. Intensified voice therapy: a new model for the rehabilitation of patients suffering from functional dysphonias.

Author: Fischer MJ, Gutenbrunner C, and Ptok M
Published: 2009
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16. Sustained effects of comprehensive inpatient rehabilitative treatment and sleeping neck support in patients with chronic cervicobrachialgia: a prospective and randomized clinical trial.

Author: Bernateck M, Karst M, Merkesdal S, Fischer MJ, and Gutenbrunner C
Published: 2008
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17. Do occlusal splints have an effect on complex regional pain syndrome? A randomized, controlled proof-of-concept trial.

Author: Fischer MJ, Reiners A, Kohnen R, Bernateck M, Gutenbrunner C, Fink M, and Svensson P
Published: 2008
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18. Large scale communication networks—Design and analysis

Author: Fischer, MJ, primary, Garbin, DA, additional, Harris, TC, additional, and Knepley, JE, additional
Published: 1978
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19. To the Editor

Author: Fischer Mj
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Text mining, business.industry, medicine.medical_treatment, General surgery, Medicine, Intubation, Surgery, Cardiology and Cardiovascular Medicine, business
Published: 1972

20. Search for the neutral Higgs bosons of the Minimal Supersymmetric Standard Model in $pp$ collisions at $\sqrt{s}=7$ TeV with the ATLAS detector

Author: Nicola Semprini-Cesari, P. Gerlach, B. M.M. Allbrooke, Raymond Veness, Givi Sekhniaidze, Heiko Lacker, Satoshi Hasegawa, Alberto Annovi, M. Svatos, A. Di Simone, C. Collins-Tooth, M. Hamer, D. Xu, H. S. Bawa, M. I. Scherzer, R. Di Nardo, Vaclav Vacek, L. Bugge, Federica Legger, Valery Khovanskiy, M. Fanti, Antonio Policicchio, R. Bartoldus, Dimitrios Fassouliotis, George Redlinger, S. Farrell, Anatoly Borisov, A. Floderus, Vadim Gratchev, S. Ask, M. P. Sanders, Xuai Zhuang, Samira Hassani, Gregor Kasieczka, J. S. Webster, Ole Røhne, Judith Katzy, Vit Vorobel, Zhenwei Yang, S. Kazama, T. Varol, Torsten Paul Ake Åkesson, R. Van Der Leeuw, Ewelina Lobodzinska, E. Sarkisyan-Grinbaum, B. Bittner, A. Lanza, J. S.H. Lee, K. M. Smith, Masaharu Nomachi, Kostantinos Kordas, Shaun Roe, Matthew Beckingham, Sourabh Dube, M. D.M. Capeans Garrido, P. Malecki, Z. Hajduk, Takahiko Kondo, Attila Krasznahorkay, Addolorata Farilla, P. Grenier, Massimiliano Bellomo, W. Fernando, Samuel Calvet, D. C. Bailey, D. Salek, Olivier Davignon, P. Starovoitov, Minghui Liu, Iwona Grabowska-Bold, Aranzazu Ruiz-Martinez, K. Benslama, P. Gauzzi, A. Mengarelli, R. Di Sipio, Igor Aleksandrov, Tony Liss, José Luís da Silva, Yaquan Fang, Kirill Prokofiev, Julius Hrivnac, Andrew D. Hamilton, T. Cuhadar Donszelmann, M. Hohlfeld, Anthony Keith Morley, Peter Wagner, Manoj Jha, Y. B. Pan, Jozsef Toth, Elena Korolkova, N. Davidson, I. Gough Eschrich, Claudio Luci, L. E. Price, Th. A. Mueller, Kathryn Grimm, M. Morii, Monica Dunford, T. Sumida, H. Wahlen, Takashi Kubota, D. Puldon, A. E. Loevschall-Jensen, Michael Ernst, Raphael Vuillermet, R. Calkins, Claudia Glasman, M. Goebel, Yoshiji Yasu, P. Banerjee, B. Clement, T. Doherty, Andreas Salzburger, M. Hauschild, Andrei Salnikov, Masahiro Ikeno, Paolo Francavilla, S. Angelidakis, M. Marx, T. J. Khoo, M. L. Chu, Arnulf Quadt, J. W. Tsung, Jiangyong Jia, R. C. Jared, M. L. Gonzalez Silva, Kevin Kroeninger, T. Kohriki, M. Medinnis, J. Virzi, Marcin Wladyslaw Wolter, Yoram Rozen, Laurent Vacavant, W. Fedorko, Sergey Kuleshov, Giancarlo Spigo, Kathleen Whalen, Lorenzo Rinaldi, Tancredi Carli, Alexander Grillo, J. E. Sundermann, Paul Laycock, Helen Hayward, Y. Zhou, Igor Gavrilenko, Adele Rimoldi, M. A. Dufour, F. Luehring, B. Butler, Yang Gao, Elliott Cheu, F. Grancagnolo, S. Schmitt, W. J. Mills, T. Yamamura, Brinick Simmons, Louise Heelan, Daniel Froidevaux, J. de Graat, M. A. Diaz, Andrzej Olszewski, James Mueller, Junichi Tanaka, R. S.B. King, Y. Doi, L. Duguid, P. Cwetanski, S. Borroni, A. D'Orazio, D. Roda Dos Santos, A. Koutsman, K. Leonhardt, P. Radloff, G. Cattani, H. Wang, H. S. Chen, A. Antonov, João Antonio Pina, M. Ugland, F. Fassi, Emmanuel Sauvan, Remi Lafaye, Christoph Rembser, Y. Pylypchenko, S. Johnert, Antonio Limosani, John Huth, A. A. Abdelalim, J. W. Chapman, Vakhtang Kartvelishvili, Tim Jones, Giuseppe Mornacchi, Joao Saraiva, V. V. Ammosov, Robert McPherson, Anthony Weidberg, J. P. Martin, Ricardo Piegaia, F. Safai Tehrani, Per Johansson, S. De Castro, Katharine Leney, S. Di Luise, Z. Meng, Davide Costanzo, J-P. Meyer, M. J. Losty, Vivek Jain, F. Friedrich, P. M. Manning, Theodoros Alexopoulos, Martin Tripiana, Raymond Brock, G. Sauvage, D. Zhang, Isabelle Wingerter-Seez, R. M. Neves, R. Nagai, B. R. Mellado Garcia, D. A. Maximov, Ch. Geich-Gimbel, Alessandro Tricoli, S. P. Bieniek, J. Godfrey, Christopher Lester, Remi Zaidan, Z. Weng, E. Tiouchichine, K. Kessoku, A. Di Mattia, Hermann Kolanoski, V. Savinov, Javier Sánchez, M. Biglietti, J. Stahlman, Ph. Schune, Konrad Kleinknecht, F. Bucci, A. Jantsch, B. Nicquevert, B. M. Wynne, Matthias Schott, Lucio Cerrito, A. Molfetas, A. Ferretto Parodi, Lamberto Luminari, J. Yu, Regina Caputo, M. A. Baak, Mark Stockton, Yoichi Ikegami, M. Byszewski, Tadeusz Kowalski, Wainer Vandelli, Nigel Hessey, Ricardo Gonçalo, B. D. Cooper, V. Moeller, C. Haber, M. Zeman, Junichi Kanzaki, Joao Seixas, A. Irles Quiles, K. Meier, L. Rosselet, James Pinfold, D. Hall, N. Soni, T. K. Nelson, Y. Wu, E. Vinek, Andrea Messina, S. I. Buda, Aidan Robson, Olga Beltramello, Nicoletta Garelli, C. Da Via, L. Lee, Philippe Mermod, P. Pani, Michael Stoebe, Michel Vetterli, Heidi Sandaker, C. Oropeza Barrera, L. Chikovani, Helfried Burckhart, K. E. Selbach, Andrew White, A. R. Gillman, M. A. Wildt, L. La Rotonda, A. J. Tanasijczuk, James Monk, G. Mirabelli, J. Glatzer, C. Mora Herrera, B. Guo, Dimitrios Sampsonidis, Imma Riu, D. A.A. Geerts, W. Lukas, M. Atkinson, Naoko Kanaya, M. Heller, E. Simioni, O. Stelzer-Chilton, W. L. Ebenstein, Lorenzo Feligioni, U. Schäfer, S. Baker, John H. L. Hansen, D. S. Damiani, Stefan Simion, R. Engelmann, G. Crosetti, P. J. Clark, Philip Phillips, Samuel Silverstein, Lydia Iconomidou-Fayard, S. Kuday, J. Howarth, Emmerich Kneringer, Alexander Khanov, Alexander Lincoln Read, T. Burgess, C. Maiani, Allison McCarn, T. Yamanaka, Mauro Iodice, Kazuhiro Yamamoto, Sabine Elles, E. Ros, Robin Middleton, Alexey Myagkov, Luc Poggioli, Paul Jackson, A. Poblaguev, N. Boelaert, S. R. Whitehead, R. E. Long, C. Bacci, Jianming Qian, S. Youssef, T. M. Bristow, G. Rivoltella, G. Negri, M. Ishitsuka, D. Hayden, U. Mallik, C. M. Hernandez, S. Yu. Sivoklokov, N. Krumnack, T. Jakoubek, Tatiana Klioutchnikova, R. Kopeliansky, E. Sedykh, A. Staude, E. B. Dieh, L. Lopes, M. Bunse, Kenneth Johns, I. Ludwig, S. Yacoob, Janet Dietrich, J. Mechnich, Horst Oberlack, James Ferrando, H. Liao, F. De Lorenzi, Alexander Fenyuk, Juan Fuster, Kristof Kreutzfeldt, Steinar Stapnes, Ludovico Pontecorvo, Nils Ruthmann, P. Adragna, T. Koi, Juerg Beringer, H. von der Schmitt, A. Tudorache, Giuseppe Iacobucci, F. Tian, Jean-Baptiste Sauvan, Diego Casadei, Doris Chromek-Burckhart, Igor Potrap, Pavlos Ioannou, E. Jansen, Martin White, Eric Feng, Enrico Pasqualucci, D. Kharchenko, Daniel M. Levin, Maria Rescigno, J. Idarraga, James Chapman, P. Steinbach, Stephen Gibson, G. Vegni, S. Kabana, B. G. 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Pahl, A. Harvey, S. Caughron, P. Sinervo, Francesco Spanò, O. M. Kind, Giuseppe Salamanna, V. Andrei, Dusan Bruncko, P. S. Wells, M. Nagel, G. G.G. Massaro, M. Neumann, H. P. Skottowe, Marcella Bona, W. Mohr, M. Tsiakiris, Nathalie Besson, D. Wicke, J. Janssen, S. Pashapour, Hao Li, S. Cabrera Urbán, F. Niedercorn, S. Becker, W. Bhimji, Driss Benchekroun, F. Alessandria, T. Vazquez Schroeder, Deywis Moreno, S. Monzani, James Proudfoot, H. Khandanyan, D. Cavalli, Serban Constantinescu, Takashi Matsushita, G. A. Cowan, O. G. Grebenyuk, Paul Dervan, Gabriella Gaudio, Y. Ming, Duc Ta, W. Blum, Ahmet Bingul, Elzbieta Richter-Was, Michal Marcisovsky, A. Khodinov, S. Yanush, Martin Aleksa, N. A. Styles, Shikma Bressler, S. Eckweiler, Regina Moles-Valls, J. Howard, F. M. Giorgi, B. C. Smith, Goeran Jarlskog, P. Loscutoff, Ulrike Blumenschein, Akira Yamamoto, T. Kluge, G. Fletcher, Tadashi Maeno, T. Fonseca Martin, M. Negrini, Simonetta Gentile, Alexey Dudarev, G. Alexandre, Brad Abbott, Maarten Boonekamp, Sergey Denisov, Martin Wessels, E. E. Kluge, Pavol Strizenec, V. Sopko, P. Klimek, Almut Pingel, Siegfried Wenig, Abdelalim Aly, Ahmed Aly, Alexandre, Gauthier, Backes, Moritz, Barone, Gaetano, Bell, Paul, Bell, William, Benhar Noccioli, Eleonora, Bucci, Francesca, Clark, Allan Geoffrey, Doglioni, Caterina, Ferrere, Didier, Gadomski, Szymon, Gonzalez Sevilla, Sergio, Goulette, Marc, Iacobucci, Giuseppe, La Rosa, Alessandro, Lister, Alison, Martin Dit Latour, Bertrand, Mermod, Philippe, Mora Herrera, Maria Clemencia Rosario, Nektarijevic, Snezana, Nikolics, Katalin, Pasztor, Arpad, Picazio, Attilio, Pohl, Martin, Rosbach, Kilian, Rosselet, Laurent, Wu, Xin, ATLAS Collaboration (ukupan broj autora: 2895), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire, Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Neutrinos, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC)-AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2884, Aad, G., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Cevenini, Francesco, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Patricelli, Sergio, Conventi, Francesco, DELLA PIETRA, Massimo, Giordano, Raffaele, Musto, Elisa, Rossi, Elvira, SANCHEZ PINEDA, ARTURO RODOLFO, Carlino, Gianpaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Sekhniaidze, Givi, Al, e. t. ., G. Aad, T. Abajyan, B. Abbott, J. Abdallah, S. Abdel Khalek, A. A. Abdelalim, O. Abdinov, R. Aben, B. Abi, M. Abolin, O. S. AbouZeid, H. Abramowicz, H. Abreu, B. S. Acharya, L. Adamczyk, D. L. Adam, T. N. Addy, J. Adelman, S. Adomeit, P. Adragna, T. Adye, S. Aefsky, J. A. Aguilar-Saavedra, M. Agustoni, S. P. Ahlen, F. Ahle, A. Ahmad, M. Ahsan, G. Aielli, T. P. A. Åkesson, G. Akimoto, A. V. Akimov, M. A. Alam, J. Albert, S. Albrand, M. Aleksa, I. N. Aleksandrov, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulo, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, B. M. M. Allbrooke, L. J. Allison, P. P. Allport, S. E. Allwood-Spier, J. Almond, A. Aloisio, R. Alon, A. Alonso, F. Alonso, A. Altheimer, B. Alvarez Gonzalez, M. G. Alviggi, K. Amako, C. Amelung, V. V. Ammosov, S. P. Amor Dos Santo, A. Amorim, S. Amoroso, N. Amram, C. Anastopoulo, L. S. Ancu, N. Andari, T. Andeen, C. F. Ander, G. Ander, K. J. Anderson, A. Andreazza, V. Andrei, M-L. Andrieux, X. S. Anduaga, S. Angelidaki, P. Anger, A. Angerami, F. Anghinolfi, A. Anisenkov, N. Anjo, A. Annovi, A. Antonaki, M. Antonelli, A. Antonov, J. Anto, F. Anulli, M. Aoki, S. Aoun, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, A. T. H. Arce, S. Arfaoui, J-F. Arguin, S. Argyropoulo, E. Arik, M. Arik, A. J. Armbruster, O. Arnaez, V. Arnal, A. Artamonov, G. Artoni, D. Arutinov, S. Asai, S. Ask, B. Åsman, L. Asquith, K. Assamagan, A. Astbury, M. Atkinson, B. Aubert, E. Auge, K. Augsten, M. Aurousseau, G. Avolio, D. Axen, G. Azuelo, Y. Azuma, M. A. Baak, G. Baccaglioni, C. Bacci, A. M. Bach, H. Bachacou, K. Bacha, M. Backe, M. Backhau, J. Backus Maye, E. Badescu, P. Bagnaia, Y. Bai, D. C. Bailey, T. Bain, J. T. Baine, O. K. Baker, S. Baker, P. Balek, E. Bana, P. Banerjee, Sw. Banerjee, D. Banfi, A. Bangert, V. Bansal, H. S. Bansil, L. Barak, S. P. Baranov, T. Barber, E. L. Barberio, D. Barberi, M. Barbero, D. Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B. M. Barnett, R. M. 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Brau, J. E. Brau, H. M. Braun, S. F. Brazzale, B. Brelier, J. Bremer, K. Brendlinger, R. Brenner, S. Bressler, T. M. Bristow, D. Britton, F. M. Brochu, I. Brock, R. Brock, F. Broggi, C. Bromberg, J. Bronner, G. Brooijman, T. Brook, W. K. Brook, G. Brown, P. A. Bruckman Renstrom, D. Bruncko, R. Bruneliere, S. Brunet, A. Bruni, G. Bruni, M. Bruschi, L. Bryngemark, T. Buane, Q. Buat, F. Bucci, J. Buchanan, P. Buchholz, R. M. Buckingham, A. G. Buckley, S. I. Buda, I. A. Budagov, B. Budick, V. Büscher, L. Bugge, O. Bulekov, A. C. Bundock, M. Bunse, T. Buran, H. Burckhart, S. Burdin, T. Burge, S. Burke, E. Busato, P. Bussey, C. P. Buszello, B. Butler, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, M. Byszewski, S. Cabrera Urbán, D. Caforio, O. Cakir, P. Calafiura, G. Calderini, P. Calfayan, R. Calkin, L. P. Caloba, R. Caloi, D. Calvet, S. Calvet, R. Camacho Toro, P. Camarri, D. Cameron, L. M. Caminada, R. Caminal Armadan, S. Campana, M. Campanelli, V. Canale, F. Canelli, A. 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Zoccoli, M. Nedden, V. Zutshi, L. Zwalinski, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), UAM. Departamento de Física Teórica, Massachusetts Institute of Technology. Department of Physics, Taylor, Frank E., Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Universidade do Minho, Aad, G, Abajyan, T, Abbott, B, Abdallah, J, Khaek, Sa, Abdelalim, Aa, Abdinov, O, Abi, B, Abolins, M, Abouzeid, O, Abramowicz, H, Abreu, H, Acharya, B, Adamczyk, L, Adams, Dl, Addy, Tn, Adelman, J, Adomeit, S, Adragna, P, Adye, T, Aesky, S, Agar Savedra, Ja, Agustoni, M, Ahlen, Sp, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akesson, Tpa, Akimoto, G, Akimov, Av, Alam, Ma, Albert, J, Albrand, S, Aleksa, M, Aleksandrov, In, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Aliev, M, Alimonti, G, Alison, J, Allbrooke, Bmm, Allison, Lj, Allport, Pp, Allwood Spiers, Se, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alonso, F, Altheimer, A, Gonzalez, Ba, Alviggi, Mg, Amako, K, Amelung, C, Ammosov, Vv, Dos Santos, Spa, Amorim, A, Amoroso, S, Amram, N, Anastopoulos, C, Ancu, L, Andari, N, Andeen, T, Anders, Cf, Anders, G, Anderson, Kj, Andreazza, A, Andrei, V, Andrieux, Ml, Anduaga, X, Angelidakis, S, Anger, P, Angerami, A, Anghinolfi, F, Anisenkov, A, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonov, A, Antos, J, Anulli, F, Aoki, M, Aoun, S, Bella, La, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, Ath, Arfaoui, S, Arguin, Jf, Argyropoulos, S, Arik, E, Arik, M, Armbruster, Aj, Arnaez, O, Arnal, V, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Atkinson, M, Aubert, B, Auge, E, Augsten, K, Aurousseau, M, Avolio, G, Axen, A, Azuelos, G, Azuma, Y, Baak, Ma, Baccaglioni, G, Bacci, C, Bach, Am, Bachacou, H, Bachas, K, Backes, M, Backhaus, M, Mayes, Jb, Badescu, E, Bagnaia, P, Bai, Y, Bailey, Dc, Bain, T, Baines, Jt, Baker, Ok, Baker, S, Balek, P, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansil, H, Barak, L, Baranov, Sp, Barber, T, Barberio, El, Barberis, D, Barbero, N, Bardin, Dy, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, Bm, Barnett, Rm, Baroncelli, A, Barone, G, Barr, Aj, Barreiro, F, da Costa, Jbg, Bartoldus, R, Barton, Ae, Bartsch, V, Basye, A, Bates, Rl, Batkova, L, Batley, Jr, Battaglia, A, Battistin, M, Bauer, F, Bawa, H, Beale, S, Beau, T, Beauchemin, Ph, Beccherle, R, Bechtle, P, Beck, Hp, Becker, K, Becker, S, Beckingham, M, Becks, Kh, Beddall, Aj, Beddall, A, Bedikian, S, Bednyakov, Va, Bee, Cp, Beemster, Lj, Begel, M, Harpaz, Sb, Behera, Pk, Beimforde, N, Belanger Champagne, C, Bell, Pj, Bell, Wh, Bella, G, Bellagamba, L, Bellomo, M, Belloni, A, Beloborodova, O, Belotskiy, K, Beltramello, O, Benary, O, Benchekroun, D, Bendtz, K, Benekos, N, Benhammou, Y, Noccioli, Eb, Garcia, Jab, Benjarnin, Dp, Benoit, M, Bensinger, Jr, Benslama, K, Bentvelsen, S, Berge, D, Kuutmann, Eb, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertella, C, Bertin, A, Bertolucci, F, Besana, Mi, Besjes, Gj, Besson, N, Bethke, S, Bhimji, W, Bianchi, Rm, Bianchini, L, Bianco, M, Biebel, O, Bieniek, Sp, Bierwagen, K, Biesiada, J, Biglietti, M, Bilokon, H, Bindi, M, Binet, S, 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Citron, Zh, Citterio, M, Ciubancan, M, Clark, A, Clark, Pj, Clarke, Rn, Cleland, W, Clemens, Jc, Clement, B, Clement, C, Coadou, Y, Cobal, M, Coccaro, A, Cochran, J, Coffey, L, Cogan, Jg, Coggeshall, J, Colas, J, Cole, S, Colijn, Ap, Collins, Nj, Collins Tooth, C, Collot, J, Colombo, T, Colon, G, Compostella, G, Muino, Pc, Coniavitis, E, Conidi, Mc, Consonni, Sm, Consorti, V, Constantinescu, S, Conta, C, Conti, G, Conventi, F, Cooke, M, Cooper, Bd, Cooper Sarkar, Am, Copic, K, Cornelissen, F, Corradi, M, Corriveau, F, Cortes Gonzalez, A, Cortiana, G, Costa, G, Costa, Mj, Costanzo, D, Cote, D, Courneyea, L, Cowan, G, Cox, Be, Cranmer, K, Crescioli, F, Cristinziani, M, Crosetti, G, Crepe Renaudin, S, Cuciuc, Cm, Almenar, Cc, Donszelmann, Tc, Cummings, J, Curatolo, M, Curtis, Cj, Cuthbert, C, Cwetanski, P, Czirr, H, Czodrowski, P, Czyezula, Z, D'Auria, S, D'Onofrio, M, D'Orazio, A, De Sousa, Mjd, Da Via, C, Dabrowski, V, Dafinca, A, Dai, T, Dallaire, F, Dallapiccola, C, Dam, M, Dameri, M, 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MICCO, Biagio, Di Nardo, R, Di Simone, A, Di Sipio, R, Diaz, Ma, Diehl, Eb, Dietrich, J, Dietzsch, Ta, Diglio, S, Yagci, Kd, Dingfelder, J, Dinut, F, Dionisi, C, Dita, P, Dita, S, Dittus, F, Djama, F, Djobava, T, do Vale, Mab, Wemans, Ad, Doan, Tko, Dobbs, M, Dobos, D, Dobson, E, Dodd, J, Doglioni, C, Doherty, T, Doi, Y, Dolcjsi, J, Dolezal, Z, Dolgoshein, Ba, Dohmac, T, Donadelli, M, Donini, J, Dopke, J, Doria, A, Dos Anjos, A, Dotti, A, Dova, Mt, Doxiadis, Ad, Doyle, At, Dressnandt, N, Dris, M, Dubbert, J, Dube, S, Dubreuil, E, Duchovni, E, Duckeck, C, Duda, D, Dudarev, A, Dudziak, F, Duhrssen, M, Duerdoth, Ip, Duflot, L, Dufour, Ma, Duguid, L, Dunford, M, Yildiz, Hd, Duxfield, R, Dwuznik, M, Duren, M, Ebenstein, Wl, Ebke, J, Eckweiler, S, Edson, W, Edwards, Ca, Edwards, Nc, Ehrenfeld, W, Eifert, T, Eigen, G, Einsweiler, K, Eisenhandler, E, Ekelof, T, El Kacimi, M, Ellert, M, Elles, S, Ellinghaus, F, Ellis, K, Ellis, N, Elmsheuser, J, Elsing, M, Emeliyanov, D, Engelmann, R, Engl, A, Epp, B, Erdmann, J, Ereditato, A, Eriksson, D, Ernst, J, Ernst, M, Ernwein, J, Errede, D, Errede, S, Ertel, E, Escalier, M, Esch, H, Escobar, C, Curull, Xe, Esposito, B, Etienne, F, Etienvre, Ai, Etzion, E, Evangelakou, D, Evans, H, Fabbri, L, Fabre, C, Fakhrutdinov, Rm, Falciano, S, Fang, Y, Fanti, M, Farbin, A, Farooque, T, Farilla, A, Farley, J, Farrell, S, Farrington, Sm, Farthouat, P, Fassi, F, Fassnacht, P, Fassouliotis, D, Fatholahzadeh, B, Favareto, A, Fayard, L, Federic, P, Fedin, Ol, Fedorko, W, Fehling Kaschek, M, Feligioni, L, Feng, C, Feng, Ej, Fenyuk, Ab, Ferencei, J, Fernando, W, Ferrag, S, Ferrando, J, Ferrara, V, Ferrari, A, Ferrari, P, Ferrari, R, de Lima, Def, Ferrer, A, Ferrere, D, Ferretti, C, Parodi, Af, Fiascaris, N, Fiedler, F, Filipcic, A, Filthaut, F, Fincke Keeler, M, Fiolhais, Mcn, Fiorini, L, Firan, A, Fischer, G, Fischer, Mj, Fitzgerald, Ea, Flechl, M, Fleck, I, Fleckner, J, Fleischmann, P, Fleischmann, S, Fletcher, G, Flick, T, Floderus, A, Castillo, Lrf, 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Usai, G, Vacavant, L, Vacek, V, Vachon, B, Vahsen, S, Valentinetti, S, Valero, A, Valery, L, Valkar, S, Gallego, Ev, Vallecorsa, S, Ferrer, Jav, Van Berg, R, Van der Deij, Pc, van der Geer, R, van der Graaf, H, Van der Leeuw, R, van der Poel, E, van der Ster, D, van Eldik, N, van Gemmeren, P, Van Nieuwkoop, J, Van Vulpen, I, Vanadia, M, Vandelli, W, Vaniachine, A, Vankov, P, Vannucci, F, Vari, R, Varnes, Ew, Varol, T, Varouchas, D, Vartapetian, A, Varvell, Ke, Vassilakopoulos, Vi, Vazeille, F, Schroeder, Tv, Vegni, G, Veillet, Jj, Veloso, F, Veness, R, Veneziano, S, Ventura, A, Ventura, D, Venturi, M, Venturi, N, Vercesi, V, Verducci, M, Verkerke, W, Vermeulen, Jc, Vest, A, Vetterli, Mc, Viehou, I, Vickey, T, Boeriu, Oev, Viehhauser, Gha, Viel, S, Villa, M, Perez, Mv, Vilucchi, E, Vincter, Mg, Vinek, E, Vinogradov, Vb, Virchaux, M, Virzi, J, Vitells, O, Viti, M, Vivarelli, I, Vaque, Fv, Vlachos, S, Vladoiu, D, Vlasak, M, Vogel, A, Vokac, P, Volpi, G, Volpi, M, Volpini, G, von der 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Porta, Gz, Zhang, D, Zhang, H, Zhang, J, Zhang, X, Zhang, Z, Zhao, L, Zhao, Z, Zhemchugov, A, Zhong, J, Zhou, B, Zhou, N, Zhou, Y, Zhu, Cg, Zhu, H, Zhu, J, Zhu, Y, Zhuang, X, Zhuravlov, V, Zibell, A, Zieminska, D, Zimin, Ni, Zimmermann, R, Zimmermann, S, Ziolkowski, M, Zitoun, R, Zivkovic, L, Zmouchko, Vv, Zobernig, G, Zoccoli, A, zur Nedden, M, Zutshi, V, Zwalinski, L., ATLAS (IHEF, IoP, FNWI), Bianco, Michele, Chiodini, G., Gorini, Edoardo, Primavera, Margherita, Spagnolo, Stefania Antonia, Ventura, Andrea, Doğuş Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, TR3959, and Çetin, Serkant Ali
Subjects: 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Naturvetenskap, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], SUPERSYMMETRY, QC, Boson, Physics, Large Hadron Collider, Settore FIS/01 - Fisica Sperimentale, Supersymmetry, ATLAS, medicine.anatomical_structure, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Higgs boson, LHC, Natural Sciences, Particle Physics - Experiment, Particle physics, Nuclear and High Energy Physics, Ciências Naturais::Ciências Físicas, 530 Physics, Ciências Físicas [Ciências Naturais], FOS: Physical sciences, ddc:500.2, Nuclear physics, Atlas (anatomy), 0103 physical sciences, medicine, ddc:530, High Energy Physics, 010306 general physics, Ciencias Exactas, Hadron-Hadron scattering, Muon, Science & Technology, Hadron-Hadron Scattering, ATLAS detector, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Física, HADRON-HADRON COLLISIONS, Experimental High Energy Physics, High Energy Physics::Experiment, Minimal Supersymmetric Standard Model, Lepton
Abstract: A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7 TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb[superscript −1] to 4.8 fb[superscript −1]. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, ϕ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters m [subscript A] and tan β in the m[max over h] scenario for m [subscript A] in the range of 90 GeV to 500 GeV., United States. Dept. of Energy, National Science Foundation (U.S.), Brookhaven National Laboratory
Published: 2012

21. HoloDIEP-Faster and More Accurate Intraoperative DIEA Perforator Mapping Using a Novel Mixed Reality Tool.

Author: Necker FN, Cholok DJ, Fischer MJ, Shaheen MS, Gifford K, Januszyk M, Leuze CW, Scholz M, Daniel BL, and Momeni A
Abstract: Background: Microsurgical breast reconstruction using abdominal tissue is a complex procedure, in part, due to variable vascular/perforator anatomy. Preoperative computed tomography angiography (CTA) has mitigated this challenge to some degree; yet it continues to pose certain challenges. The ability to map perforators with Mixed Reality has been demonstrated in case studies, but its accuracy has not been studied intraoperatively. Here, we compare the accuracy of "HoloDIEP" in identifying perforator location (vs. Doppler ultrasound) by using holographic 3D models derived from preoperative CTA., Methods: Using a custom application on HoloLens, the deep inferior epigastric artery vascular tree was traced in 15 patients who underwent microsurgical breast reconstruction. Perforator markings were compared against the 3D model in a coordinate system centered on the umbilicus. Holographic- and Doppler-identified markings were compared using a perspective-corrected photo technique against the 3D model along with measurement of duration of perforator mapping for each technique., Results: Vascular points in HoloDIEP skin markings were -0.97 ± 6.2 mm (perforators: -0.62 ± 6.13 mm) away from 3D-model ground-truth in radial length from the umbilicus at a true distance of 10.81 ± 6.14 mm (perforators: 11.40 ± 6.15 mm). Absolute difference in radial distance was twice as high for Doppler markings compared with Holo-markings (9.71 ± 6.16 and 4.02 ± 3.20 mm, respectively). Only in half of all cases (7/14), more than 50% of the Doppler-identified points were reasonably close (<30 mm) to 3D-model ground-truth. HoloDIEP was twice as fast as Doppler ultrasound (76.9s vs. 150.4 s per abdomen)., Conclusion: HoloDIEP allows for faster and more accurate intraoperative perforator mapping than Doppler ultrasound., Competing Interests: F. Necker is a part-time research student at Siemens Healthineers (Erlangen, Germany). Dr. C.W. Leuze is a co-founder and owner of Nakamir, Inc. (Menlo Park, CA). Dr. A. Momeni is a consultant for AxoGen, Gore, RTI, and Sientra. The remaining authors have no conflict of interest to disclose., (Thieme. All rights reserved.)
Published: 2024
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22. Leveraging the Apple Ecosystem: Easy Viewing and Sharing of Three-dimensional Perforator Visualizations via iPad/iPhone-based Augmented Reality.

Author: Necker FN, Cholok DJ, Shaheen MS, Fischer MJ, Gifford K, El Chemaly T, Leuze CW, Scholz M, Daniel BL, and Momeni A
Abstract: We introduce a novel technique using augmented reality (AR) on smartphones and tablets, making it possible for surgeons to review perforator anatomy in three dimensions on the go. Autologous breast reconstruction with abdominal flaps remains challenging due to the highly variable anatomy of the deep inferior epigastric artery. Computed tomography angiography has mitigated some but not all challenges. Previously, volume rendering and different headsets were used to enable better three-dimensional (3D) review for surgeons. However, surgeons have been dependent on others to provide 3D imaging data. Leveraging the ubiquity of Apple devices, our approach permits surgeons to review 3D models of deep inferior epigastric artery anatomy segmented from abdominal computed tomography angiography directly on their iPhone/iPad. Segmentation can be performed in common radiology software. The models are converted to the universal scene description zipped format, which allows immediate use on Apple devices without third-party software. They can be easily shared using secure, Health Insurance Portability and Accountability Act-compliant sharing services already provided by most hospitals. Surgeons can simply open the file on their mobile device to explore the images in 3D using "object mode" natively without additional applications or can switch to AR mode to pin the model in their real-world surroundings for intuitive exploration. We believe patient-specific 3D anatomy models are a powerful tool for intuitive understanding and communication of complex perforator anatomy and would be a valuable addition in routine clinical practice and education. Using this one-click solution on existing devices that is simple to implement, we hope to streamline the adoption of AR models by plastic surgeons., Competing Interests: Necker is a part-time research student at Siemens Healthineers (Erlangen, Germany). Dr. Leuze is a co-founder and owner of Nakamir Inc (Menlo Park, Calif.). Dr. Momeni is a consultant for AxoGen, Gore, RTI, and Sientra. All the other authors have no financial interest to declare in relation to the content of this article. This study was supported by BaCaTeC—Bavaria California Technology Center, Erlangen, Germany (an institution fostering collaborations between Bavaria and California funded by the Bavarian State Ministry for Science and Art)., (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
Published: 2024
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23. Prevalence and Risk Factors of Fatigue in Adults with Stage 3 and 4 CKD: Findings from the National Health and Nutrition Examination Survey, 2007-2012.

Author: Hannan MF, Tintle N, Fischer MJ, and Doorenbos AZ
Subjects: Humans, Prevalence, Risk Factors, Adult, Female, Male, Middle Aged, United States epidemiology, Aged, Nutrition Surveys, Fatigue epidemiology, Fatigue etiology, Renal Insufficiency, Chronic epidemiology
Published: 2024
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24. Suture Packaging as a Marker for Intraoperative Image Alignment in Augmented Reality on Mobile Devices.

Author: Necker FN, Cholok DJ, Shaheen MS, Fischer MJ, Gifford K, Le Castillo C, Scholz M, Leuze CW, Daniel BL, and Momeni A
Abstract: Preoperative vascular imaging has become standard practice in the planning of microsurgical breast reconstruction. Currently, translating perforator locations from radiological findings to a patient's abdomen is often not easy or intuitive. Techniques using three-dimensional printing or patient-specific guides have been introduced to superimpose anatomy onto the abdomen for reference. Augmented and mixed reality is currently actively investigated for perforator mapping by superimposing virtual models directly onto the patient. Most techniques have found only limited adoption due to complexity and price. Additionally, a critical step is aligning virtual models to patients. We propose repurposing suture packaging as an image tracking marker. Tracking markers allow quick and easy alignment of virtual models to the individual patient's anatomy. Current techniques are often complicated or expensive and limit intraoperative use of augmented reality models. Suture packs are sterile, readily available, and can be used to align abdominal models on the patients. Using an iPad, the augmented reality models automatically align in the correct position by using a suture pack as a tracking marker. Given the ubiquity of iPads, the combination of these devices with readily available suture packs will predictably lower the barrier to entry and utilization of this technology. Here, our workflow is presented along with its intraoperative utilization. Additionally, we investigated the accuracy of this technology., Competing Interests: F. Necker is a part-time research student at Siemens Healthineers (Erlangen, Germany). Dr. C.W. Leuze is a co-founder and owner of Nakamir Inc (Menlo Park, Calif.). Dr. A. Momeni is a consultant for AxoGen, Gore, RTI, and Sientra. F. Necker and Dr. M. Scholz have been funded by Bavaria California Technology Center (BaCaTeC), Erlangen, Germany (an institution fostering collaborations between Bavaria and California funded by the Bavarian State Ministry for Science and Art). F. Necker is a scholarship recipient and part of the Graduate Center at the Bavarian Research Institute for Digital Transformation (Munich, Germany) funded by the Bavarian State Ministry for Science and Art. All the other authors have no financial interest to declare in relation to the content of this article., (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.)
Published: 2024
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25. The Reconstructive Metaverse - Collaboration in Real-Time Shared Mixed Reality Environments for Microsurgical Reconstruction.

Author: Necker FN, Cholok DJ, Shaheen MS, Fischer MJ, Gifford K, El Chemaly T, Leuze CW, Scholz M, Daniel BL, and Momeni A
Abstract: Plastic surgeons routinely use 3D-models in their clinical practice, from 3D-photography and surface imaging to 3D-segmentations from radiological scans. However, these models continue to be viewed on flattened 2D screens that do not enable an intuitive understanding of 3D-relationships and cause challenges regarding collaboration with colleagues. The Metaverse has been proposed as a new age of applications building on modern Mixed Reality headset technology that allows remote collaboration on virtual 3D-models in a shared physical-virtual space in real-time. We demonstrate the first use of the Metaverse in the context of reconstructive surgery, focusing on preoperative planning discussions and trainee education. Using a HoloLens headset with the Microsoft Mesh application, we performed planning sessions for 4 DIEP-flaps in our reconstructive metaverse on virtual patient-models segmented from routine CT angiography. In these sessions, surgeons discuss perforator anatomy and perforator selection strategies whilst comprehensively assessing the respective models. We demonstrate the workflow for a one-on-one interaction between an attending surgeon and a trainee in a video featuring both viewpoints as seen through the headset. We believe the Metaverse will provide novel opportunities to use the 3D-models that are already created in everyday plastic surgery practice in a more collaborative, immersive, accessible, and educational manner., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: F. Necker is a part-time research student at Siemens Healthineers (Erlangen, Germany). Dr. C.W. Leuze is a co-founder and owner of Nakamir Inc (Menlo Park, CA). Dr. A. Momeni is a consultant for AxoGen, Gore, RTI, and Sientra. The remaining authors have no conflict of interest to disclose.
Published: 2024
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26. Utilization of Mental Health Provision, Epistemic Stance and Comorbid Psychopathology of Individuals with Complex Post-Traumatic Stress Disorders (CPTSD)-Results from a Representative German Observational Study.

Author: Riedl D, Kampling H, Nolte T, Kirchhoff C, Kruse J, Sachser C, Fegert JM, Gündel H, Brähler E, Grote V, Fischer MJ, and Lampe A
Abstract: Background : Complex post-traumatic stress disorder (CPTSD) is a severely debilitating recently added symptom cluster in the International Classification of Diseases (ICD-11). So far, only limited information on mental health treatment-uptake and -satisfaction of individuals with CPTSD is available. The aim of this study is to investigate these aspects in a representative sample of the German general population. Methods : Participants completed the International Trauma Questionnaire (ITQ) to identify participants with CPTSD, as well as questionnaires on mental health treatment uptake and satisfaction, adverse childhood experiences, anxiety, depression, working ability, personality functioning, and epistemic trust. Results : Of the included n = 1918 participants, n = 29 (1.5%) fulfilled the criteria for CPTSD. Participants with CPTSD had received mental health treatment significantly more often than participants with PTSD or depression (65.5% vs. 58.8% vs. 31.6%; p = 0.031) but reported significantly less symptom improvement (52.9% vs. 78.0% vs. 80.0%; p = 0.008). Lower levels of epistemic trust were associated with higher CPTSD symptoms ( p < 0.001). Conclusions : Our study shows that while the vast majority of individuals with CPTSD had received mental health treatment, subjective symptom improvement rates are not satisfactory. CPTSD was associated with a broad number of comorbidities and impairments in functioning. Lower levels of epistemic trust may partially explain worse treatment outcomes.
Published: 2024
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27. Adherence to Plant-Based Diets and Risk of CKD Progression and All-Cause Mortality: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Author: Amir S, Kim H, Hu EA, Ricardo AC, Mills KT, He J, Fischer MJ, Pradhan N, Tan TC, Navaneethan SD, Dobre M, Anderson CAM, Appel LJ, and Rebholz CM
Subjects: Adult, Aged, Female, Humans, Male, Middle Aged, Cohort Studies, Disease Progression, Patient Compliance, Prospective Studies, Risk Factors, Diet, Plant-Based, Mortality, Renal Insufficiency, Chronic mortality, Renal Insufficiency, Chronic diet therapy
Abstract: Rationale & Objective: Studies have shown that generally healthy individuals who consume diets rich in plant foods have a lower risk of incident chronic kidney disease (CKD) and cardiovascular disease. This study investigated the prospective associations of plant-based diets with the risk of CKD progression and all-cause mortality in individuals with CKD., Study Design: Prospective cohort study., Setting & Participants: 2,539 participants with CKD recruited between 2003-2008 into the Chronic Renal Insufficiency Cohort (CRIC) Study., Exposure: Responses on the Diet History Questionnaire were used to calculate scores for the overall plant-based diet index, healthy plant-based diet index, and unhealthy plant-based diet index., Outcome: (1) CKD progression defined as≥50% estimated glomerular filtration rate decline from baseline or kidney replacement therapy (dialysis, transplant) and (2) all-cause mortality., Analytical Approach: Cox proportional hazards models to compute hazard ratios and 95% confidence intervals adjusting for lifestyle, socioeconomic, and clinical covariates., Results: There were 977 CKD progression events and 836 deaths during a median follow-up period of 7 and 12 years, respectively. Participants with the highest versus lowest adherence to overall plant-based diets and healthy plant-based diets had 26% (HR, 0.74 [95% CI, 0.62-0.88], P trend<0.001) and 21% (HR, 0.79 [95% CI, 0.66-0.95], P trend=0.03) lower risks of all-cause mortality, respectively. Each 10-point higher score of unhealthy plant-based diets was modestly associated with a higher risk of CKD progression (HR, 1.14 [95% CI, 1.03-1.25) and all-cause mortality (HR, 1.11 [95% CI, 1.00-1.23)., Limitations: Self-reported diet may be subject to measurement error., Conclusions: Adherence to an overall plant-based diet and a healthy plant-based diet is associated with a reduced risk of all-cause mortality among individuals with CKD. An unhealthy plant-based was associated with an elevated risk of CKD progression and all-cause mortality., Plain-Language Summary: Plant-based diets are healthful dietary patterns that have been linked to a lower risk of chronic diseases. However, the impact of plant-based diets on clinical outcomes in patients with chronic kidney disease (CKD) is not well established. In 2,539 individuals with CKD, we examined the associations of adherence to 3 different types of plant-based diets with the risks of CKD progression and all-cause mortality. We found that following an overall plant-based diet and a healthy plant-based diet was associated with a lower risk of all-cause mortality. By contrast, following an unhealthy plant-based diet was associated with a higher risk of CKD progression and all-cause mortality. These results suggest that the quality of plant-based diets may be important for CKD management., (Copyright © 2023 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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28. Increasing DIEA Perforator Detail in 3D Photorealistic Volume Rendering Visualizations with Skin-masking and Cinematic Anatomy.

Author: Necker FN, Cholok DJ, Shaheen MS, Fischer MJ, Gifford K, El Chemaly T, Leuze CW, Scholz M, Daniel BL, and Momeni A
Abstract: Preoperative CT angiography (CTA) is increasingly performed prior to perforator flap-based reconstruction. However, radiological 2D thin-slices do not allow for intuitive interpretation and translation to intraoperative findings. 3D volume rendering has been used to alleviate the need for mental 2D-to-3D abstraction. Even though volume rendering allows for a much easier understanding of anatomy, it currently has limited utility as the skin obstructs the view of critical structures. Using free, open-source software, we introduce a new skin-masking technique that allows surgeons to easily create a segmentation mask of the skin that can later be used to toggle the skin on and off. Additionally, the mask can be used in other rendering applications. We use Cinematic Anatomy for photorealistic volume rendering and interactive exploration of the CTA with and without skin. We present results from using this technique to investigate perforator anatomy in deep inferior epigastric perforator flaps and demonstrate that the skin-masking workflow is performed in less than 5 minutes. In Cinematic Anatomy, the view onto the abdominal wall and especially onto perforators becomes significantly sharper and more detailed when no longer obstructed by the skin. We perform a virtual, partial muscle dissection to show the intramuscular and submuscular course of the perforators. The skin-masking workflow allows surgeons to improve arterial and perforator detail in volume renderings easily and quickly by removing skin and could alternatively also be performed solely using open-source and free software. The workflow can be easily expanded to other perforator flaps without the need for modification., Competing Interests: Conflict of Interest Statement: F. Necker is a part-time research student at Siemens Healthineers (Erlangen, Germany). Dr. C.W. Leuze is a co-founder and owner of Nakamir Inc (Menlo Park, CA). Dr. A. Momeni is a consultant for AxoGen, Gore, RTI, and Sientra. The remaining authors have no conflict of interest to disclose., (Copyright © 2024 by the American Society of Plastic Surgeons.)
Published: 2024
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29. Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study.

Author: Hernandez R, Xie D, Wang X, Jordan N, Ricardo AC, Anderson AH, Diamantidis CJ, Kusek JW, Yaffe K, Lash JP, and Fischer MJ
Abstract: Rationale & Objective: The extent to which depression affects the progression of chronic kidney disease (CKD) and leads to adverse clinical outcomes remains inadequately understood. We examined the association of depressive symptoms (DS) and antidepressant medication use on clinical outcomes in 4,839 adults with nondialysis CKD., Study Design: Observational cohort study., Setting and Participants: Adults with mild to moderate CKD who participated in the multicenter Chronic Renal Insufficiency Cohort Study (CRIC)., Exposure: The Beck Depression Inventory (BDI) was used to quantify DS. Antidepressant use was identified from medication bottles and prescription lists. Individual effects of DS and antidepressants were examined along with categorization as follows: (1) BDI <11 and no antidepressant use, (2) BDI <11 with antidepressant use, (3) BDI ≥11 and no antidepressant use, and (4) BDI ≥11 with antidepressant use., Outcomes: CKD progression, incident cardiovascular disease composite, all-cause hospitalizations, and mortality., Analytic Approach: Cox regression models were fitted for outcomes of CKD progression, incident cardiovascular disease, and all-cause mortality, whereas hospitalizations used Poisson regression., Results: At baseline, 27.3% of participants had elevated DS, and 19.7% used antidepressants. Elevated DS at baseline were associated with significantly greater risk for an incident cardiovascular disease event, hospitalization, and all-cause mortality, but not CKD progression, adjusted for antidepressants. Antidepressant use was associated with higher risk for all-cause mortality and hospitalizations, after adjusting for DS. Compared to participants without elevated DS and not using antidepressants, the remaining groups (BDI <11 with antidepressants; BDI ≥11 and no antidepressants; BDI ≥11 with antidepressants) showed higher risks of hospitalization and all-cause mortality., Limitations: Inability to infer causality among depressive symptoms, antidepressants, and outcomes. Additionally, the absence of nonpharmacological data, and required exploration of generalizability and alternative analytical approaches., Conclusions: Elevated DS increased adverse outcome risk in nondialysis CKD, unattenuated by antidepressants. Additionally, investigation into the utilization and counterproductivity of antidepressants in this population is warranted., (© 2024 The Authors.)
Published: 2024
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30. Spatial Fidelity of Microvascular Perforating Vessels as Perceived by Augmented Reality Virtual Projections.

Author: Cholok DJ, Fischer MJ, Leuze CW, Januszyk M, Daniel BL, and Momeni A
Subjects: Humans, Computed Tomography Angiography, Tomography, X-Ray Computed methods, Epigastric Arteries, Perforator Flap blood supply, Augmented Reality, Mammaplasty methods
Abstract: Background: Autologous breast reconstruction yields improved long-term aesthetic results but requires increased resources of practitioners and hospital systems. Innovations in radiographic imaging have been increasingly used to improve the efficiency and success of free flap harvest. Augmented reality affords the opportunity to superimpose relevant imaging on a surgeon's native field of view, potentially facilitating dissection of anatomically variable structures. To validate the spatial fidelity of augmented reality projections of deep inferior epigastric perforator flap-relevant anatomy, comparisons of three-dimensional (3D) models and their virtual renderings were performed by four independent observers. Measured discrepancies between the real and holographic models were evaluated., Methods: The 3D-printed models of deep inferior epigastric perforator flap-relevant anatomy were fabricated from computed tomographic angiography data from 19 de-identified patients. The corresponding computed tomographic angiography data were similarly formatted for the Microsoft HoloLens to generate corresponding projections. Anatomic points were initially measured on 3D models, after which the corresponding points were measured on the HoloLens projections from two separate vantage points (V1 and V2). Statistical analyses, including generalized linear modeling, were performed to characterize spatial fidelity regarding translation, rotation, and scale of holographic projections., Results: Among all participants, the median translational displacement at corresponding points was 9.0 mm between the real-3D model and V1, 12.1 mm between the 3D model and V2, and 13.5 mm between V1 and V2., Conclusion: Corresponding points, including topography of perforating vessels, for the purposes of breast reconstruction can be identified within millimeters, but there remain multiple independent contributors of error, most notably the participant and location at which the projection is perceived., (Copyright © 2023 by the American Society of Plastic Surgeons.)
Published: 2024
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31. Responsiveness of Isokinetic Dynamometry in Patients with Osteoarthritis after Knee and Hip Arthroplasty: A Prospective Repeated-Measures Cohort Study.

Author: Prüfer F, Pavlović M, Matko Š, Löfler S, Fischer MJ, Šarabon N, and Grote V
Abstract: Functional assessments are crucial for the evaluation of rehabilitation after total knee (TKA) and hip (THA) arthroplasty. Muscle strength, a key determinant of physical function (PF), is often measured with isokinetic dynamometry (ID), which is considered the gold standard. However, studies lack evaluations of responsiveness-the ability to detect changes over time. This study aims to determine the responsiveness of ID in measuring PF in TKA and THA rehabilitation-is muscle strength a valid indicator for assessing improvement in rehabilitation processes? The pre- and post-surgery PF of 20 osteoarthritis patients (age 55-82) was assessed, using ID, performance-based and self-reported measures. Responsiveness was evaluated by comparing the observed relationship of changes in ID and PF scores with the a priori defined expected relationship of change scores. While the performance-based and self-reported measures showed significant improvements post-surgery (Cohen's d [0.42, 1.05] p < 0.05), ID showed no significant differences. Moderate correlations were found between changes in some ID parameters and selected functional tests ( r ≈| 0.5 | , p < 0.05). Responsiveness was solely found for the peak torque of knee extension at 180°/s on the operated side. Responsiveness is an often-overlooked psychometric property of outcome measurements. The findings suggest that ID may not be fully responsive to the construct of PF after TKA and THA, raising questions about its role and usefulness in this context and the need for more appropriate assessment methods.
Published: 2024
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32. The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis.

Author: Dember LM, Hsu JY, Bernardo L, Cavanaugh KL, Charytan DM, Crowley ST, Cukor D, Doorenbos AZ, Edwards DA, Esserman D, Fischer MJ, Jhamb M, Joffe S, Johansen KL, Kalim S, Keefe FJ, Kimmel PL, Krebs EE, Kuzla N, Mehrotra R, Mishra P, Pellegrino B, Steel JL, Unruh ML, White DM, Yabes JG, and Becker WC
Subjects: Humans, Analgesics, Opioid therapeutic use, Multicenter Studies as Topic, Pain Management, Randomized Controlled Trials as Topic, Renal Dialysis adverse effects, Buprenorphine therapeutic use, Chronic Pain drug therapy, Chronic Pain epidemiology
Abstract: The HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis (HOPE Trial) is a multicenter randomized trial addressing chronic pain among patients receiving maintenance hemodialysis for end-stage kidney disease. The trial uses a sequential, multiple assignment design with a randomized component for all participants (Phase 1) and a non-randomized component for a subset of participants (Phase 2). During Phase 1, participants are randomized to Pain Coping Skills Training (PCST), an intervention designed to increase self-efficacy for managing pain, or Usual Care. PCST consists of weekly, live, coach-led cognitive behavioral therapy sessions delivered by video- or tele-conferencing for 12 weeks followed by daily interactive voice response sessions delivered by telephone for an additional 12 weeks. At 24 weeks (Phase 2), participants in both the PCST and Usual Care groups taking prescription opioid medications at an average dose of ≥20 morphine milligram equivalents per day are offered buprenorphine, a partial opioid agonist with a more favorable safety profile than full-agonist opioids. All participants are followed for 36 weeks. The primary outcome is pain interference ascertained, for the primary analysis, at 12 weeks. Secondary outcomes include additional patient-reported measures and clinical outcomes including falls, hospitalizations, and death. Exploratory outcomes include acceptability, tolerability, and efficacy of buprenorphine. The enrollment target of 640 participants was met 27 months after trial initiation. The findings of the trial will inform the management of chronic pain, a common and challenging issue for patients treated with maintenance hemodialysis. NCT04571619., Competing Interests: Declaration of Competing Interest L.M. Dember receives compensation from the National Kidney Foundation for her role as Deputy Editor of the American Journal of Kidney Diseases, consulting fees from AstraZeneca, Cara Therapeutics, and Merck, and compensation for serving on Data and Safety Monitoring Boards for the National Institute of Diabetes and Digestive and Kidney Diseases, CSL Behring, and Vertex Pharmaceuticals. D.M. Charytan reports consulting fees from Eli Lilly, Boehringer Ingelheim, Astra Zeneca, Allena Pharmaceuticals (DSMB), Fresenius, Gilead, Novo Nordisk, GSK, Medtronic, Merck, Amgen, CSL Behring, Zogenix, and Renalytix; research funding from Medtronic, clinical trial support from Gilead, NovoNordisk, Amgen, and Boehringer Ingelheim; royalties from UpToDate.com for authorship or editorial activities; and expert witness fees related to proton pump inhibitors. D. Esserman serves on data monitoring boards for Ablative Solutions and PhaseBio. M. Jhamb reports research funding from Bayer LLC, Dialysis Clinic Inc. and Pfizer, and advisory board fees from Xcenda LLC, Boehringer Ingelheim, Lilly, and CKD Networks of Excellence. S. Joffe reports compensation for service on a Data and Safety Monitoring Board for CSL Behring. K.L. Johansen reports consultancy for GlaxoSmithKline, Akebia, and Vifor; advisory or leadership role for GSK; and role as an Associate Editor of Journal of the American Society of Nephrology. S. Kalim reports receiving speaking fees and consulting fees from Fresenius Kabi. P.L. Kimmel reports compensation from Elsevier for his roles as Co-Editor of Chronic Renal Disease, and Co-Editor of Psychosocial Aspects of Chronic Kidney Disease. E.J. Krebs receives research funding from the US Department of Veterans Affairs (VA), National Institutes of Health (NIH), and the Patient Centered Outcomes Research Institute (PCORI), has received support (paid to her institution) from Origin Editorial for serving as Associate Editor for PCORI research reports, travel expense reimbursement from the American College of Physicians, and has provided unpaid expert service as a member of the Foundation for Opioid Response Efforts Scientific Advisory Council, temporary member (ad hoc) for the Food and Drug Administration (FDA) Drug Safety and Risk Management Advisory Committee, panel member for FDA Public Workshop on Reconsidering Mandatory Opioid Prescriber Education, member of Society of General Internal Medicine (SGIM) program and award committees, and chair or member of data safety monitoring boards for VA, NIH, and PCORI studies. R. Mehrotra serves as the Editor-in-Chief of the Clinical Journal of the American Society of Nephrology. J.L. Steel reports compensation for serving on a Data and Safety Monitoring Board for the National Institute of Diabetes and Digestive and Kidney Diseases and for her role as an editor for the Journal of Gastrointestinal Cancers, and royalties from Springer. L. Bernardo, K.L. Cavanaugh, S.T. Crowley, D. Cukor A.Z. Doorenbos, D.A. Edwards, M.J. Fischer, N. Kuzla, P. Mishra, B. Pellegrino, D.M. White, and J.G. Yabes have no disclosures., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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33. Improvements of complex post-traumatic stress disorder symptoms during a multimodal psychodynamic inpatient rehabilitation treatment - results of an observational single-centre pilot study.

Author: Lampe A, Riedl D, Kampling H, Nolte T, Kirchhoff C, Grote V, Fischer MJ, and Kruse J
Subjects: Humans, Pilot Projects, Inpatients, Psychotherapy, Surveys and Questionnaires, Stress Disorders, Post-Traumatic psychology
Abstract: Background: Complex post-traumatic stress disorder (CPTSD) describes chronic disturbances in self-organization (i.e. affect dysregulation; negative self-concept; severe difficulties in relationships) which are frequently observed in survivors of prolonged, repeated or multiple traumatic stressors. So far, evidence of psychodynamic treatment approaches for CPTSD is scarce. Methods: In this single-centre observational pilot study, symptom change during a 6-week psychodynamic inpatient treatment in a multimodal psychosomatic rehabilitation centre was evaluated using repeated measures analyses of variance (ANOVAs). Patients completed questionnaires on PTSD and CPTSD symptoms (ITQ), anxiety, depression and somatization (BSI-18), functional impairment (WHODAS) and epistemic trust, mistrust and credulity (ETMCQ) before ( T1 ) and at the end of treatment ( T2 ). A hierarchical linear regression analysis was calculated to identify factors associated with improved CPTSD symptoms. Results: A total of n = 50 patients with CPTSD were included in the study, of whom n = 40 (80%) completed treatment. Patients reported a significant reduction of CPTSD symptoms during treatment with a large effect size (-3.9 points; p < .001; η 2 = .36), as well as a significant reduction of psychological distress ( p < .001; η 2 = .55) and functional impairment ( p < .001; η 2 = .59). At the end of treatment, 41.0% of patients no longer fulfilled the diagnostic criteria for CPTSD. Changes in epistemic stance included improved epistemic trust ( β = -.34, p = .026) and decreased epistemic credulity ( β = .37, p = .017), which together with lower age ( β = .43, p = .012) and lower depression levels at baseline ( β = .35, p = .054) were significantly associated with baseline adjusted mean change of CPTSD symptoms during therapy and explained 48% of its variance. Discussion: In our study, patients reported a significant reduction of CPTSD symptoms and comorbid symptoms during a multimodal psychodynamic inpatient rehabilitation treatment. Improved epistemic trust may facilitate the establishment of a trusting therapeutic relationship, thus fostering an environment of openness for knowledge transfer (i.e. social learning) and the exploration of diverse viewpoints and perspectives in the therapeutic process.
Published: 2024
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34. Epistemic Trust Is a Critical Success Factor in Psychosomatic Rehabilitation-Results from a Naturalistic Multi-Center Observational Study.

Author: Riedl D, Kampling H, Kruse J, Nolte T, Labek K, Kirchhoff C, Grote V, Fischer MJ, Knipel A, and Lampe A
Abstract: Knowledge about critical success factors underpinning beneficial treatment outcomes in psychosomatic inpatient rehabilitation is scarce. The aim of this study was to evaluate the influence of patients' epistemic stance in relation to the improvement of psychological distress during rehabilitation. In this naturalistic longitudinal observational study, n = 771 patients completed routine assessments for psychological distress (BSI-18), health-related quality of life (HRQOL; WHODAS), and epistemic trust (ETMCQ) before (T1) and after (T2) psychosomatic rehabilitation. Patients were grouped as best, average, and worst responders based on their mean BSI-18 changes during treatment, and their mean change in epistemic trust, mistrust, and credulity was compared using repeated measures analyses of variance (rANOVAs). No associations of performance with sex ( p = 0.09), age ( p = 0.11), or relationship status ( p = 0.58) were found. Best responders reported significantly improved epistemic trust ( p = 0.001) and reduced epistemic mistrust ( p < 0.001), whereas worst responders reported a significant increase in epistemic mistrust ( p < 0.001) and credulity ( p < 0.001). Average responders did not change for either epistemic trust ( p = 0.11), mistrust ( p > 0.99), or credulity ( p = 0.96). Our results underscore the role of the epistemic stance in psychosomatic and psychotherapeutic treatments. These results help to better understand what might determine psychosomatic rehabilitation outcomes and indicate the role of epistemic trust as a critical success factor.
Published: 2023
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35. Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Author: Babroudi S, Tighiouart H, Schrauben SJ, Cohen JB, Fischer MJ, Rahman M, Hsu CY, Sozio SM, Weir M, Sarnak M, Yaffe K, Tamura MK, and Drew D
Subjects: Adult, Humans, Middle Aged, Aged, Blood Pressure, Longitudinal Studies, Disease Progression, Prospective Studies, Glomerular Filtration Rate, Risk Factors, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology, Hypertension epidemiology, Cognitive Dysfunction diagnosis, Cognitive Dysfunction epidemiology, Cognitive Dysfunction etiology, Dementia
Abstract: Rationale & Objective: Hypertension is a known risk factor for dementia and cognitive impairment. There are limited data on the relation of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with incident cognitive impairment in adults with chronic kidney disease. We sought to identify and characterize the relationship among blood pressure, cognitive impairment, and severity of decreased kidney function in adults with chronic kidney disease., Study Design: Longitudinal cohort study., Setting & Participants: 3,768 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study., Exposure: Baseline SBP and DBP were examined as exposure variables, using continuous (linear, per 10-mm Hg higher), categorical (SBP<120 [reference], 120 to 140,>140mm Hg; DBP<70 (reference), 70 to 80, > 80mm Hg) and nonlinear terms (splines)., Outcome: Incident cognitive impairment defined as a decline in Modified Mini-Mental State Examination (3MS) score to greater than 1 standard deviation below the cohort mean., Analytical Approach: Cox proportional hazard models adjusted for demographics as well as kidney disease and cardiovascular disease risk factors., Results: The mean age of participants was 58±11 (SD) years, estimated glomerular filtration rate (eGFR) was 44mL/min/1.73m 2 ± 15 (SD), and the median follow-up time was 11 (IQR, 7-13) years. In 3,048 participants without cognitive impairment at baseline and with at least 1 follow-up 3MS test, a higher baseline SBP was significantly associated with incident cognitive impairment only in the eGFR>45mL/min/1.73m 2 subgroup (adjusted hazard ratio [AHR], 1.13 [95% CI, 1.05-1.22] per 10mm Hg higher SBP]. Spline analyses, aimed at exploring nonlinearity, showed that the relationship between baseline SBP and incident cognitive impairment was J-shaped and significant only in the eGFR>45mL/min/1.73m 2 subgroup (P=0.02). Baseline DBP was not associated with incident cognitive impairment in any analyses., Limitations: 3MS test as the primary measure of cognitive function., Conclusions: Among patients with chronic kidney disease, higher baseline SBP was associated with higher risk of incident cognitive impairment specifically in those individuals with eGFR>45mL/min/1.73m 2 ., Plain-Language Summary: High blood pressure is a strong risk factor for dementia and cognitive impairment in studies of adults without kidney disease. High blood pressure and cognitive impairment are common in adults with chronic kidney disease (CKD). The impact of blood pressure on the development of future cognitive impairment in patients with CKD remains unclear. We identified the relationship between blood pressure and cognitive impairment in 3,076 adults with CKD. Baseline blood pressure was measured, after which serial cognitive testing was performed over 11 years. Fourteen percent of participants developed cognitive impairment. We found that a higher baseline systolic blood pressure was associated with an increased risk of cognitive impairment. We found that this association was stronger in adults with mild-to-moderate CKD compared with those with advanced CKD., (Copyright © 2023 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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36. Usability of Electronic Patient-Reported Outcome Measures for Older Patients With Cancer: Secondary Analysis of Data from an Observational Single Center Study.

Author: Riedl D, Lehmann J, Rothmund M, Dejaco D, Grote V, Fischer MJ, Rumpold G, Holzner B, and Licht T
Subjects: Adult, Male, Humans, Female, Aged, Adolescent, Young Adult, Middle Aged, Aged, 80 and over, Retrospective Studies, Inpatients, Electronics, Patient Reported Outcome Measures, Quality of Life, Neoplasms therapy
Abstract: Background: Patient-reported outcomes are considered the gold standard for assessing subjective health status in oncology patients. Electronic assessment of patient-reported outcomes (ePRO) has become increasingly popular in recent years in both clinical trials and practice. However, there is limited evidence on how well older patients with cancer can complete ePRO assessments., Objective: We aimed to investigate how well adult patients with cancer of different age ranges could complete ePRO assessments at home and in a treatment facility and to identify factors associated with the ability to complete questionnaires electronically., Methods: This retrospective longitudinal single-center study involved survivors of cancer who participated in inpatient rehabilitation. Patients completed ePRO assessments before rehabilitation at home (T1) and after rehabilitation at the facility (T2). We analyzed the rate of patients who could complete the ePRO assessment at T1 and T2, the proportion of patients who required assistance, and the time it took patients to complete standardized questionnaires. Multivariate logistic regression analyses were conducted to identify predictors of ePRO completion rate and the need for assistance., Results: Between 2017 and 2022, a total of 5571 patients were included in this study. Patients had a mean age of 60.3 (SD 12.2) years (range 18 to 93 years), and 1135 (20.3%) of them were classified as geriatric patients (>70 years). While more than 90% (5060/5571) of all patients completed the ePRO assessment, fewer patients in the age group of >70 years (924/1135, 81.4% at T1 vs 963/1135, 84.8% at T2) completed the assessment. Approximately 19% (1056/5571) of patients reported a need for assistance with the ePRO assessment at home, compared to 6.8% (304/4483) at the institution. Patients older than 70 years had a significantly higher need for assistance than those in younger age groups. Moreover, a gender difference was observed, with older women reporting a higher need for assistance than men (71-80 years: women requiring assistance 215/482, 44.6% vs men 96/350, 27.4%; P<.001 and >80 years: women 102/141, 72.3% vs men 57/112, 50.9%; P<.001). On average, patients needed 4.9 (SD 3.20) minutes to remotely complete a 30-item questionnaire (European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire) and patients in the older age groups took significantly longer compared to younger age groups. Lower age and higher physical functioning were the clearest predictors for both the ePRO completion rate and the need for assistance in the multivariate regression analysis., Conclusions: This study's results indicate that ePRO assessment is feasible in older individuals with cancer, but older patients may require assistance (eg, from relatives) to complete home-based assessments. It may be more feasible to conduct assessments in-house in this population. Additionally, it is crucial to carefully consider which resources are necessary and available to support patients in using ePRO devices., (©David Riedl, Jens Lehmann, Maria Rothmund, Daniel Dejaco, Vincent Grote, Michael J Fischer, Gerhard Rumpold, Bernhard Holzner, Thomas Licht. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 21.09.2023.)
Published: 2023
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37. Needs and Considerations for Standardization of Kidney Disease Education in Patients with Advanced CKD.

Author: Shukla AM, Cavanaugh KL, Jia H, Hale-Gallardo J, Wadhwa A, Fischer MJ, Reule S, Palevsky PM, Fried LF, and Crowley ST
Subjects: Humans, United States, Hemodialysis, Home education, Reference Standards, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic therapy, Renal Insufficiency
Abstract: Kidney health advocacy organizations and leaders in the nephrology community have repeatedly emphasized the need to increase home dialysis utilization in the United States. Limited awareness and understanding of options for the management of kidney failure among patients living with advanced CKD is a significant barrier to increasing the selection and use of home dialysis. Studies have shown that providing targeted comprehensive patient education before the onset of kidney failure can improve patients' awareness of kidney disease and substantially increase the informed utilization of home dialysis. Unfortunately, in the absence of validated evidence-based education protocols, outcomes associated with home dialysis use vary widely among published studies, potentially affecting the routine implementation and reporting of these services among patients with advanced CKD. This review provides pragmatic guidance on establishing effective patient-centered education programs to empower patients to make informed decisions about their KRT and, in turn, increase home dialysis use., (Copyright © 2023 by the American Society of Nephrology.)
Published: 2023
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38. Short-Term Effects of Dietary Protein Supplementation on Physical Recovery in Older Patients at Risk of Malnutrition during Inpatient Rehabilitation: A Pilot, Randomized, Controlled Trial.

Author: Strasser B, Grote V, Bily W, Nics H, Riedl P, Jira I, and Fischer MJ
Abstract: It is estimated that about 50% of geriatric rehabilitation patients suffer from sarcopenia. Thereby, malnutrition is frequently associated with sarcopenia, and dietary intake is the main modifiable risk factor. During hospitalization, older adults are recommended to consume more dietary protein than the current recommended dietary allowance of 0.8 g/kg body weight per day to optimize the recovery of muscular strength and physical function. This prospective pilot study examined the feasibility and preliminary efficacy of short-term protein supplementation with protein-enriched foods and drinks on the hand-grip strength, nutritional status, and physical function of older patients at risk of malnutrition during a three-week inpatient orthopedic rehabilitation stay. The Mini Nutritional Assessment (MNA) tool was used to assess malnutrition. Patients with an MNA score ≤ 23.5 points were randomly assigned to an intervention group (goal: to consume 1.2-1.5 g protein/kg body weight per day) or a control group (standard care). Both groups carried out the same rehabilitation program. Physical recovery parameters were determined at admission and discharge. A trend was recognized for participants in the intervention group to consume more protein than the control group ( p = 0.058): 95.3 (SD 13.2) g/day as compared to 77.2 (SD 24.2) g/day, which corresponds to a mean protein intake of 1.6 (SD 0.3) g/kg/day vs. 1.3 (SD 0.5) g/kg/day. Dietary protein supplementation increased body weight by an average of 0.9 (SD 1.1) kg and fat mass by an average of 0.9 (SD 1.2) kg as compared to the baseline ( p = 0.039 and p = 0.050, respectively). No significant change in hand-grip strength, body composition, or physical function was observed. In conclusion, short-term intervention with protein-enriched foods and drinks enabled older patients at risk of malnutrition to increase their protein intake to levels that are higher than their required intake. In these older individuals with appropriate protein intake, dietary protein supplementation did not result in a greater improvement in physical recovery outcomes during short-term inpatient rehabilitation. The intervention improved dietary protein intake, but further research (e.g., a full-scale, randomized, controlled trial with sufficient power) is required to determine the effects on physical function outcomes.
Published: 2023
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39. Mentalizing and epistemic trust as critical success factors in psychosomatic rehabilitation: results of a single center longitudinal observational study.

Author: Riedl D, Rothmund MS, Grote V, Fischer MJ, Kampling H, Kruse J, Nolte T, Labek K, and Lampe A
Abstract: Background: Inpatient psychosomatic rehabilitation is a key treatment for patients with mental health issues. However, knowledge about critical success factors for beneficial treatment outcomes is scarce. The aim of this study was to evaluate the association of mentalizing and epistemic trust with the improvement of psychological distress during rehabilitation., Methods: In this naturalistic longitudinal observational study, patients completed routine assessments of psychological distress (BSI), health-related quality of life (HRQOL; WHODAS), mentalizing (MZQ), and epistemic trust (ETMCQ) before (T1) and after (T2) psychosomatic rehabilitation. Repeated measures ANOVA (rANOVAs) and structural equation models (SEMs) were calculated to investigate the association of mentalizing and epistemic trust with the improvement in psychological distress., Results: A total sample of n = 249 patients were included in the study. Improvement in mentalizing was correlated with improvement in depression ( r = 0.36), anxiety ( r = 0.46), and somatization ( r = 0.23), as well as improved cognition ( r = 0.36), social functioning ( r = 0.33), and social participation ( r = 0.48; all p < 0.001). Mentalizing partially mediated changes in psychological distress between T1 and T2: the direct association decreased from β = 0.69 to β = 0.57 and the explained variance increased from 47 to 61%. Decreases in epistemic mistrust (β = 0.42, 0.18-0.28; p < 0.001) and epistemic credulity (β = 0.19, 0.29-0.38; p < 0.001) and increases in epistemic trust (β = 0.42, 0.18-0.28; p < 0.001) significantly predicted improved mentalizing. A good model fit was found ( χ 2 = 3.248, p = 0.66; CFI = 0.99; TLI = 0.99; RMSEA = 0.000)., Conclusion: Mentalizing was identified as a critical success factor in psychosomatic inpatient rehabilitation. A key component to increase mentalizing in this treatment context is the improvement of epistemic mistrust., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Riedl, Rothmund, Grote, Fischer, Kampling, Kruse, Nolte, Labek and Lampe.)
Published: 2023
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40. Association between Depressive Symptom Trajectory and Chronic Kidney Disease Progression: Findings from the Chronic Renal Insufficiency Cohort Study.

Author: Missikpode C, Ricardo AC, Brown J, Durazo-Arvizi RA, Fischer MJ, Hernandez R, Porter AC, Cook JA, Anderson A, Dolata J, Feldman HI, Horwitz E, Lora C, Wright Nunes J, Rao PS, and Lash JP
Subjects: Humans, Cohort Studies, Depression epidemiology, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Kidney Failure, Chronic epidemiology
Published: 2023
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41. Prospective associations of health literacy with clinical outcomes in adults with CKD: findings from the CRIC study.

Author: Estrella ML, Allen-Meares P, Ricardo AC, Fischer MJ, Gordon EJ, Carmona-Powell E, Sondheimer J, Chen J, Horwitz E, Wang X, Hsu JY, Lash JP, and Lora C
Subjects: Humans, Adult, Cohort Studies, Prospective Studies, Risk Factors, Health Literacy, Renal Insufficiency, Chronic complications, Heart Failure complications, Peripheral Arterial Disease, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology
Abstract: Background: Limited health literacy is associated with significant morbidity and mortality in the general population but the relation of health literacy with long-term clinical outcomes among adults with chronic kidney disease (CKD) is less clear., Methods: Prospective data from the Chronic Renal Insufficiency Cohort (CRIC) Study (n = 3715) were used. Health literacy was assessed with the Short Test of Functional Health Literacy in Adults (dichotomized as limited/adequate). Cox proportional hazards models were used to separately examine the relations of health literacy with CKD progression, cardiovascular event (any of the following: myocardial infarction, congestive heart failure, stroke or peripheral artery disease), and all-cause, cardiovascular and non-cardiovascular mortality. Poisson regression was used to assess the health literacy-hospitalization association. Models were sequentially adjusted: Model 1 adjusted for potential confounders (sociodemographic factors), while Model 2 additionally adjusted for potential mediators (clinical and lifestyle factors) of the associations of interest., Results: In confounder-adjusted models, participants with limited (vs adequate) health literacy [555 (15%)] had an increased risk of CKD progression [hazard ratio (HR) 1.34; 95% confidence interval (CI) 1.06-1.71], cardiovascular event (HR 1.67; 95% CI 1.39-2.00), hospitalization (rate ratio 1.33; 95% CI 1.26-1.40), and all-cause (HR 1.54; 95% CI 1.27-1.86), cardiovascular (HR 2.39; 95% CI 1.69-3.38) and non-cardiovascular (HR 1.27; 95% CI 1.01-1.60) mortality. Additional adjustments for potential mediators (Model 2) showed similar results except that the relations of health literacy with CKD progression and non-cardiovascular mortality were no longer statistically significant., Conclusions: In the CRIC Study, adults with limited (vs adequate) health literacy had a higher risk for CKD progression, cardiovascular event, hospitalization and mortality-regardless of adjustment for potential confounders., (© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.)
Published: 2023
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42. Phase 1 Study to Evaluate the Safety of Reducing the Prophylactic Dose of Dexamethasone around Docetaxel Infusion in Patients with Prostate and Breast Cancer.

Author: Lugtenberg RT, de Groot S, Houtsma D, Dezentjé VO, Vulink AJE, Fischer MJ, Portielje JEA, van der Hoeven JJM, Gelderblom H, Pijl H, and Kroep JR
Abstract: Background: There is little evidence that supports the registered high dose of dexamethasone used around docetaxel. However, this high dose is associated with considerable side effects. This study evaluates the feasibility of reducing the prophylactic oral dosage of dexamethasone around docetaxel infusion., Patients and Methods: Eligible patients had a histologically confirmed diagnosis of prostate or breast cancer and had received at least three cycles of docetaxel as monotherapy or combination therapy. Prophylactic dexamethasone around docetaxel infusion was administered in a de-escalating order per cohort of patients. Primary endpoint was the occurrence of grade III/IV fluid retention and hypersensitivity reactions (HSRs)., Results: Of the 46 enrolled patients, 39 were evaluable (prostate cancer ( n = 25), breast cancer ( n = 14). In patients with prostate cancer, the dosage of dexamethasone was reduced to a single dose of 4 mg; in patients with breast cancer, the dosage was reduced to a 3-day schedule of 4 mg-8 mg-4 mg once daily, after which no further reduction has been tested. None of the 39 patients developed grade III/IV fluid retention or HSR. One patient (2.6%) had a grade 1 HSR, and there were six patients (15.4%) with grade I or II edema. There were no differences in quality of life (QoL) between cohorts., Conclusions: It seems that the prophylactic dose of dexamethasone around docetaxel infusion can be safely reduced with respect to the occurrence of grade III/IV HSRs or the fluid retention syndrome.
Published: 2023
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43. Controversial Outcomes in Neck Rehabilitation between Surgically and Conservatively Treated Patients-Results of an Observational Study.

Author: Missmann M, Grote V, Riedl D, Grenier JP, and Fischer MJ
Abstract: The present study aimed to compare changes during inpatient rehabilitation between conservatively and surgically treated patients. A total of n = 162 patients with cervical spine complaints were included in the study ( n = 107 conservatively treated, n = 55 after surgery). Patients completed disease-specific (NDI) and generic (NPRS, EQ-5D-5L, HAQ) patient reported outcome measures (PROMs) before and after rehabilitation. In addition, the range of motion (ROM) in the transversal plane of the cervical spine was measured. Changes and correlations between PROMs and ROM values during rehabilitation were assessed. The influence of moderating factors on NDI outcomes was examined. Significant improvements with large effect sizes were found in PROMs and ROM (all p < 0.001). The conservatively treated patients showed significantly greater NDI improvements than operated patients ( p = 0.050), but a greater proportion of poor performance in ROM ( p = 0.035). Baseline NDI (β = 0.66), HAQ (β = 0.14), and ROM scores (β = -0.17) explained 63.7% of the variance in NDI after rehabilitation. Both patient groups showed different outcomes. The findings of this study indicate that the unique needs of patients may require different therapeutic interventions and highlight the importance of using multidimensional outcome measures when implementing a multimodal rehabilitation approach.
Published: 2023
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44. Gender-Specific Significance of Peer Abuse during Childhood and Adolescence on Physical and Mental Health in Adulthood-Results from a Cross-Sectional Study in a Sample of Hospital Patients.

Author: Lampe A, Nolte T, Schmid M, Kampling H, Kruse J, Grote V, Fischer MJ, and Riedl D
Subjects: Adolescent, Male, Humans, Child, Female, Adult, Mental Health, Cross-Sectional Studies, Hospitals, Child Abuse psychology, Adverse Childhood Experiences
Abstract: Peer abuse (PA) is a widespread and gender-sensitive form of Adverse Childhood Experiences (ACEs). However, research on its influence on physical and mental health in adulthood remains scarce. The aim of this study was to investigate gender-specific associations between PA and physical and mental health in adulthood in a sample of general hospital patients. A cross-sectional study at the University Hospital of Innsbruck was conducted. Data on ACEs, physical and mental health were collected using self-report questionnaires. We compared patients with no ACEs, PA only, ACEs without PA, and ACEs with PA using gender-specific binary logistic regressions to investigate the association of PA with physical and mental health. A total of 2,392 patients were included in the analyses. Women reported more emotional PA (13.1% vs. 9.4%; p = 0.006), while men reported more physical PA (8.3% vs. 5.2%; p = 0.003). PA was associated with a higher likelihood for depression (OR = 2.6), somatization (OR = 2.1), as well as worse physical health (OR = 2.1) in women but not in men. This study is the first to present data on the gender-specific detrimental effect of PA on physical and mental health in adulthood. Especially for women, PA poses a significant health risk. Thus, we should be aware of these effects and offer adequate support for affected individuals.
Published: 2022
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45. Large Improvements in Health-Related Quality of Life and Physical Fitness during Multidisciplinary Inpatient Rehabilitation for Pediatric Cancer Survivors.

Author: Riedl D, Licht T, Nickels A, Rothmund M, Rumpold G, Holzner B, Grote V, Fischer MJ, and Fischmeister G
Abstract: Rehabilitation is a key element in improving health-related quality of life (HRQOL) for pediatric cancer survivors. The aim of this study was to present data from a multidisciplinary inpatient rehabilitation treatment. Children took part in a four-week multidisciplinary family-oriented inpatient rehabilitation. A total of 236 children (>5−21 years) and 478 parents routinely completed electronic patient-reported outcomes (ePROs), performance-based assessments, and clinician-rated assessments before (T1) and at the end (T2) of rehabilitation. HRQOL was assessed with the PedsQL generic core and PedsQL cancer module. Data were analyzed using repeated measures analysis of variance (ANOVA). Statistically significant improvements with medium to large effect sizes were observed for most HRQOL scales (η2 = 0.09−0.31), as well as performance-based and clinician-rated assessments for physical activity and functional status (η2 > 0.28). Agreement between children’s PROs and parents’ proxy ratings was lower before (rICC = 0.72) than after (rICC = 0.86) rehabilitation. While the concordance between children and parents’ assessment of changes during rehab was low to moderate (r = 0.19−0.59), the use of the performance score led to substantially increased scores (r = 0.29−0.68). The results of this naturalistic observational study thus highlight the benefits of multidisciplinary pediatric inpatient rehabilitation for childhood cancer survivors. The use of the performance score is recommended in this field.
Published: 2022
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46. Performance Score (T2D)-A New Perspective in the Assessment of Six-Minute Walking Tests in Pulmonary Rehabilitation.

Author: Wagner B, Zdravkovic A, Pirchl M, Puhan MA, Zwick RH, Grote V, Crevenna R, and Fischer MJ
Abstract: Because absolute changes in outcomes are difficult to interpret and the minimal clinically important difference (MCID) is not suitable to address this challenge, a novel method of classifying outcomes by relating changes to baseline values is warranted. We used the "performance score" (T2D), which reflects individual performance, enabling us to consider the functional status at the beginning of rehabilitation without dealing with the problems of mathematical coupling or regression effects, as encountered in ANCOVA. To illustrate the T2D, we retrospectively analyzed changes in the six-minute walking test (6MWT) in COPD patients undergoing outpatient pulmonary rehabilitation and compared the results with absolute differences related to a predetermined MCID. We evaluated a total of 575 COPD patients with a mean age of 61.4 ± 9.2 years. 6MWT improved significantly, with a mean change of 32.3 ± 71.2. A total of 105/311 participants who had reached the MCID were still classified as "below average" by the T2D. Conversely, 76/264 patients who had not reached the MCID were classified as "above average". This new performance measure accounts for the patient's current status and for changes over time, potentially representing a simple and user-friendly tool that can be used to quantify a patient's performance and response to rehabilitation.
Published: 2022
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47. Acceptability and feasibility of fecal microBIOME and serum metabolite sample collection in people with end-stage kidney disease and pain being treated with HemoDialysis: A pilot study (BIOME-HDp).

Author: Lockwood MB, Fischer MJ, Silva K, Contreras BN, Zamora G, Goldstein A, Meinel M, Holden C, Lash J, Steffens A, and Doorenbos A
Abstract: Pain is known to reduce hemodialysis treatment adherence, reduce quality of life, and increase mortality. The absence of effective strategies to treat pain without medications has contributed to poor health outcomes for people with end-stage kidney disease (ESKD) on hemodialysis. It is now recognized that symbiotic microbiota in the gut play a critical role in health and disease, and new evidence sheds light on the role of the microbiome in chronic pain. The pilot study protocol presented here (BIOME-HDp) employs a longitudinal repeated measures design to interrogate the effects of a nonpharmacological pain intervention on the composition and function of the gut microbiome and circulating metabolites. This pilot study is an ancillary study of the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis, which is part of the NIH's Helping to End Addiction Long-term (HEAL) initiative. The BIOME-HDp pilot study will establish clinical microbiome research methods and determine the acceptability and feasibility of fecal microbiome and serum metabolite sample collection., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Authors.)
Published: 2022
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48. Impact of Different Isokinetic Movement Patterns on Shoulder Rehabilitation Outcome.

Author: Missmann M, Gollner K, Schroll A, Pirchl M, Grote V, and Fischer MJ
Subjects: Activities of Daily Living, Cohort Studies, Exercise Therapy, Hand Strength, Humans, Range of Motion, Articular, Shoulder Pain, Treatment Outcome, Shoulder, Shoulder Joint
Abstract: Shoulder pain is regularly associated with limited mobility and limitations in activities of daily living. In occupational therapy, various interventions, including active isokinetic training with a Baltimore Therapeutic Equipment (BTE) Work Simulator, help the patient improve shoulder mobility and alleviate pain. This randomized controlled cohort study aims to evaluate the impact of different isokinetic movement patterns on the DASH score, pain, and objective performance measures, such as range of motion (ROM) and hand grip strength. Patients that participated in a specific 3-week inpatient orthopedic rehabilitation were divided into two groups. The first group (UNI-group, n = 9) carried out uniplanar exercises for shoulder flexion, abduction, and external rotation. The patients in the second group (ADL-group, n = 10) imitated multiplanar everyday movements, such as climbing on a ladder, loading a shopping cart, and raising a glass to their mouth. Compared to the UNI-group, the ADL-group improved significantly in DASH scores (mean -10.92 ± 12.59 vs. -22.83 ± 11.31), pain (NPRS -1.11 ± 2.37 vs. 3.70 ± 2.00), and shoulder abduction (+2.77 ± 15.22 vs. +25.50 ± 21.66 degrees). In conclusion, the specific BTE exercise program with multiplanar movement patterns contributed considerably to the therapeutic improvement.
Published: 2022
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49. Health Insurance Coverage Among Veterans Receiving Care From VA Health Care Facilities.

Author: Stroupe KT, Martinez R, Hogan TP, Gordon EJ, Gonzalez B, Tarlov E, Silva A, Huo Z, Kale I, Ippolito D, Osteen C, Jordan N, French DD, Gordon H, Fischer MJ, and Smith BM
Subjects: Delivery of Health Care, Humans, Interviews as Topic, Midwestern United States, Patient Protection and Affordable Care Act, Surveys and Questionnaires, United States, United States Department of Veterans Affairs, Insurance Coverage, Insurance, Health, Veterans, Veterans Health Services economics
Abstract: Reasons for acquiring insurance outside Department of Veterans Affairs (VA) health care coverage among VA enrollees are incompletely understood. To assess Veterans' decision-making and acquisition of non-VA health care insurance in the Affordable Care Act era, we used mailed questionnaires and semistructured interviews in a stratified random sample of VA enrollees <65 years in the Midwest. Of the 3,666 survey participants, 32.1% reported non-VA insurance. Frequently reported reasons included wanting coverage for emergency situations or family members. Those without non-VA insurance cited unaffordability as the main obstacle. Analysis of the semistructured interview data revealed similar findings. In multivariable logistic regression analyses, characteristics associated with non-VA insurance included higher income (>$50,000 vs. <$10,000, odds ratio [OR] = 5.95, 95% confidence interval [CI]: 3.45-10.3, p < .001). As financial barriers exist for acquisition of non-VA insurance and hence community care, it is critically important that VA enrollees' health care needs are met through VA or community providers financed through VA.
Published: 2022
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50. Inflamed Tumor Phenotype as Predictor of Long-Term Response to Pembrolizumab in an EGFR-Mutated Non-Small Cell Lung Cancer (NSCLC) Patient with Acquired Resistance to Afatinib: a Case Report and Review of the Literature.

Author: Baglivo S, Mandarano M, Bellezza G, Minotti V, Bonaiti A, Fischer MJ, Birocchi I, Roila F, Metelli N, Ludovini V, and Metro G
Abstract: Treatment with immune checkpoint inhibitors (ICIs) that target the programmed cell death 1/programmed cell death ligand-1 (PD-1/PD-L1) axis is usually ineffective in patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC), either as first-line treatment or in later lines. By contrast, especially for patients with common EGFR mutations (exon 19 deletion/L858R point mutation), an orally bioavailable EGFR tyrosine kinase inhibitor (EGFR-TKI) is the best upfront therapy, being able to provide response rates well above 50% and a median progression-free survival ranging from 11 to 19 months, depending on whether a second-generation (e.g., afatinib) or a third-generation (i.e., osimertinib) EGFR-TKI is used. Unfortunately, treatment options for these patients at the time of acquired resistance are limited. As for afatinib-pretreated patients, those who develop a T790M mutation may benefit from osimertinib, whereas platinum-based chemotherapy is the preferable therapeutic strategy for T790M-negative patients as well as for patients who progress on osimertinib administered as first-line therapy. Here, we describe the case of an exon-19-deleted patient who experienced a complete response to the anti-PD-1 agent pembrolizumab upon the development of T790M-negative acquired resistance to afatinib. Furthermore, we discuss this case in the context of the existing literature, especially focusing on the importance of evaluating multiple markers of immune response post-EGFR-TKI and prior to ICI treatment in order to select the best treatment strategy in this clinical scenario., (© 2022. The Author(s).)
Published: 2022
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