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4. Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial

Author

Polymeris, Alexandros A., Karwacki, Grzegorz M., Siepen, Bernhard M., Schaedelin, Sabine, Tsakiris, Dimitrios A., Stippich, Christoph, Guzman, Raphael, Nickel, Christian H., Sprigg, Nikola, Kägi, Georg, Vehoff, Jochen, Barinka, Filip, Thilemann, Sebastian, Maurer, Marina, Wagner, Benjamin, Traenka, Christopher, Gensicke, Henrik, De Marchis, Gian Marco, Bonati, Leo H., Fischer, Urs, Z’Graggen, Werner J., Nedeltchev, Krassen, Wegener, Susanne, Baumgartner, Philipp, Engelter, Stefan T., Seiffge, David J., Peters, Nils, Lyrer, Philippe A., Clarke, Sandra, Falcao, Martina, Avramiotis, Nikolaos S, Dittrich, Tolga, Fisch, Urs, Fladt, Joachim, Hert, Lisa, Schneider, Iris, Wiegert, Martina, Zietz, Annaelle, Beyeler, Morin, Goeldlin, Martina, Kormann, Marianne, Maamari, Basel, McEvoy, Liselotte, Meinel, Thomas R, Müller, Madlaina, Vynckier, Jan, Ardila, Elena, Feuerstein, Ingrid, Gantenbein, Claudine, Müller, Anna, Seljmani, Vjosa, Wagner, Benedikt, Anders, Bettina, Backhaus, Roland, Paliantonis, Asterios, Taheri, Shadi, Thumm, Dennis, van Duinen, Jannie, and Von Bieberstein, Lita

Published
2023
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5. Electroencephalographic compatibility with fitness to drive: A nationwide survey among Swiss neurologists.

Author

Spöndlin, Leo, Hardmeier, Martin, Sutter, Raoul, Lee, Jong Woo, Rüegg, Stephan, and Fisch, Urs

Subjects
BRAIN waves, EPILEPTIFORM discharges, TRAFFIC safety, SEIZURES (Medicine), ELECTROENCEPHALOGRAPHY
Abstract

Objective: The Swiss guidelines for driving with epilepsy require that electroencephalogram (EEG) findings must be compatible with the fitness to drive (FTD) without specifying any criteria. This nationwide survey investigated how Swiss neurologists implement this requirement in clinical practice. Methods: An online survey, including 19 EEG examples and statements about the compatibility of the EEG with FTD, was distributed to all members of the Swiss Society of Clinical Neurophysiology and all Swiss neurological clinics with residency programs. Descriptive statistics and Fleiss' Kappa for inter‐rater agreement were performed. Results: 102 participants (37% female, 45% <45 years) completed the survey, with 15% primarily working in a specialized epileptology center (EPI), 55% in a hospital setting without epileptological focus (HOS), and 30% in private practice (PP). Most participants of all three groups regarded EEG normal variants as compatible with FTD, while hyperventilation‐induced rhythmic slowing and some pathological patterns (e.g., frontal and temporal intermittent rhythmic delta activity [FIRDA, TIRDA], focal interictal epileptiform discharges [IED], focal seizure) were evaluated more heterogeneously. The EEG inter‐rater agreement for EPI was 0.4; 0.31 for PP; and 0.24 for HOS. No consensus was found for acceptable duration for generalized or focal IEDs. Among all participants, evaluation by an epilepsy center (85%) and reaction‐time testing (67%) were evaluated as the most useful additional examinations. However, reaction‐time testing is rarely or never performed by 58%. Most supported EEG results as part of the FTD assessment and demanded more research (both 82%). Significance: Our survey indicates considerable heterogeneity among Swiss neurologists when evaluating the EEG findings for FTD. Inter‐rater agreement in all three groups was fair, with highest agreement among epileptologists. We noted a discrepancy between the usefulness and actual application of reaction‐time testing. More training and research are warranted to achieve rater‐independent consistency for FTD evaluation. Plain Language Summary: In Switzerland, neurologists must consider the findings from EEG (brain waves) exams to evaluate driving safety in people with epilepsy. We surveyed Swiss neurologists, asking their opinions on this matter. We found that opinions differ among individual doctors, with the highest agreement among epilepsy specialists. We also found that some additional tests, such as reaction‐time testing, are perceived as useful but are rarely performed. The participating neurologists supported considering EEG results for driving fitness assessments but favored more precise guidelines and research. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Editor's Choice – Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled Trials

Author

Fisch, Urs, von Felten, Stefanie, Wiencierz, Andrea, Jansen, Olav, Howard, George, Hendrikse, Jeroen, Halliday, Alison, Fraedrich, Gustav, Eckstein, Hans-Henning, Calvet, David, Bulbulia, Richard, Becquemin, Jean-Pierre, Algra, Ale, Rothwell, Peter, Ringleb, Peter, Mas, Jean-Louis, Brown, Martin M., Brott, Thomas G., and Bonati, Leo H.

Published
2021
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7. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial

Author

Kahles, Timo, Nedeltchev, Krassen, Altersberger, Valerian, Bonati, Leo H, Brehm, Alex, Bruni, Nicole, De Marchis, Gian Marco, Engelter, Stefan T, Fabbro, Thomas, Fisch, Urs, Fladt, Joachim, Gensicke, Henrik, Hert, Lisa, Lyrer, Philippe A, Maurer, Marina, Peters, Nils, Polymeris, Alexandros, Psychogios, Marios-Nikos, Schaedelin, Sabine, Stippich, Christoph, Thilemann, Sebastian, Traenka, Christopher, Wagner, Benjamin, Arnold, Marcel, Fischer, Urs, Goeggel Simonetti, Barbara, Gralla, Jan, Heldner, Mirjam, Jung, Simon, Leib, Stephen L, Seiffge, David J, Mueller, Hubertus, Sveikata, Lukas, Sztajzel, Roman, Correia, Pamela, Eskandari, Ashraf, Meyer, Ivo, Michel, Patrik, Nannoni, Stefania, Remillard, Suzette, Sirimarco, Gaia, Zachariadis, Alexandros, Kaegi, Georg, Mueller, Anna, Vehoff, Jochen, Hamann, Janne, Luft, Andreas R, Steiner, Levke, Wegener, Susanne, Erdur, Hebun J, Nolte, Christian H, von Rennenberg, Regina, Scheitz, Jan F, Feil, Katharina, Kellert, Lars, Christensen, Hanne, Rosenbaum, Sverre, Schaedelin, Sabine A, Simonetti, Barbara Goeggel, Kägi, Georg, Seiffge, David, Polymeris, Alexandros A, and Lyrer, Philippe

Published
2021
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9. Anti-GABAA receptor encephalitis 14 months after allogeneic haematopoietic stem-cell transplant for acute myeloid leukaemia

Author

Rusche, Thilo, primary, Yaldizli, Özgür, additional, Galbusera, Riccardo, additional, Mutke, Matthias, additional, Halter, Jörg P, additional, Lieb, Johanna, additional, Matteazzi, Francesca, additional, Stelmes, Anne, additional, Bittner, Jan, additional, Grzonka, Pascale, additional, Frank, Nicole, additional, Cordier, Dominik, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Hirsch, Hans H, additional, Fischer, Urs, additional, Kuhle, Jens, additional, Sutter, Raoul, additional, Rüegg, Stephan, additional, and Fisch, Urs, additional

Published
2024
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11. Effectiveness of a Chlorhexidine Dressing on Silver-coated External Ventricular Drain–associated Colonization and Infection : A Prospective Single-blinded Randomized Controlled Clinical Trial

Author

Roethlisberger, Michel, Moffa, Giusi, Fisch, Urs, Wiggli, Benedikt, Schoen, Stephan, Kelly, Christopher, Leu, Severina, Croci, Davide, Zumofen, Daniel W., Cueni, Nadine, Nogarth, Danica, Schulz, Marianne, Bucher, Heiner C., Weisser-Rohacek, Maja, Wasner, Morten-Goetz, Widmer, Andreas F., and Mariani, Luigi

Published
2018

14. Syncope or seizure: that is the question—case report of a young patient with convulsive cardioinhibitory syncope treated with cardioneuroablation.

Author

Papa, Andrea, Fisch, Urs, Bassetti, Stefano, Badertscher, Patrick, and Krisai, Philipp

Subjects
EPILEPSY, SYNCOPE, SEIZURES (Medicine), LOSS of consciousness, ASYMPTOMATIC patients, DIFFERENTIAL diagnosis, CARDIAC arrest
Abstract

Background Differentiation of syncope from seizure is challenging and has therapeutic implications. Cardioinhibitory reflex syncope typically affects young patients where permanent pacing should be avoided whenever possible. Cardioneuroablation may obviate the need for a pacemaker in well-selected patients. Case summary A previously healthy 24-year-old woman was referred to the emergency department after recurrent episodes of transient loss of consciousness (TLOC). The electrocardiogram (ECG) and the echocardiogram were normal. An electroencephalogram (EEG) showed intermittent, generalized pathological activity. During EEG under photostimulation, the patient developed a short-term TLOC followed by brachial myocloni, while the concurrent ECG registered a progressive bradycardia, which turned into a complete atrioventricular block and sinus arrest with asystole for 14 s. Immediately after, the patient regained consciousness without sequelae. The episode was interpreted as cardioinhibitory convulsive syncope. However, due to the pathological EEG findings, an underlying epilepsy with ictal asystole could not be fully excluded. Therefore, an antiseizure therapy was also started. After discussing the consequences of pacemaker implantation, the patient agreed to undergo a cardioneuroablation and after 72 h without complications, she was discharged home. At 10 months, the patient autonomously discontinued the antiepileptics. The follow-up EEG displayed unspecific activities without clinical correlations. An implantable loop recorder didn't show any relevant bradyarrhythmia. At 1-year follow-up, the patient remained asymptomatic and without syncopal episodes. Discussion Reflex syncope must be considered in the differential diagnosis of seizures. The cardioneuroablation obviated the need for a pacemaker and allowed for the withdrawal of anticonvulsants, originally started on the premise of seizure. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The impact of competing stroke etiologies in patients with atrial fibrillation

Author

Zietz, Annaelle, primary, Polymeris, Alexandros A, additional, Helfenstein, Fabrice, additional, Schaedelin, Sabine, additional, Hert, Lisa, additional, Wagner, Benjamin, additional, Seiffge, David J, additional, Traenka, Christopher, additional, Altersberger, Valerian L, additional, Dittrich, Tolga, additional, Kaufmann, Josefin, additional, Ravanelli, Flavia, additional, Fladt, Joachim, additional, Fisch, Urs, additional, Thilemann, Sebastian, additional, De Marchis, Gian Marco, additional, Gensicke, Henrik, additional, Bonati, Leo H, additional, Katan, Mira, additional, Fischer, Urs, additional, Lyrer, Philippe, additional, Engelter, Stefan T, additional, and Peters, Nils, additional

Published
2023
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17. The impact of competing stroke etiologies in patients with atrial fibrillation

Author

Zietz, Annaelle, Polymeris, Alexandros A, Helfenstein, Fabrice, Schaedelin, Sabine, Hert, Lisa, Wagner, Benjamin, Seiffge, David J, Traenka, Christopher, Altersberger, Valerian L, Dittrich, Tolga, Kaufmann, Josefin, Ravanelli, Flavia, Fladt, Joachim, Fisch, Urs, Thilemann, Sebastian, De Marchis, Gian Marco, Gensicke, Henrik, Bonati, Leo H, Katan, Mira, Fischer, Urs, Lyrer, Philippe, Engelter, Stefan T, and Peters, Nils

Subjects
610 Medicine & health
Abstract

BACKGROUND Data on the impact of competing stroke etiologies in stroke patients with atrial fibrillation (AF) are scarce. METHODS We used prospectively obtained data from an observational registry (Novel-Oral-Anticoagulants-in-Ischemic-Stroke-Patients-(NOACISP)-LONGTERM) of consecutive AF-stroke patients treated with oral anticoagulants. We compared the frequency of (i) the composite outcome of recurrent ischemic stroke (IS), intracerebral hemorrhage (ICH) or all-cause death as well as (ii) recurrent IS alone among AF-stroke patients with versus without competing stroke etiologies according to the TOAST classification. We performed cox proportional hazards regression modeling adjusted for potential confounders. Furthermore, the etiology of recurrent IS was assessed. RESULTS Among 907 patients (median age 81, 45.6% female), 184 patients (20.3%) had competing etiologies, while 723 (79.7%) had cardioembolism as the only plausible etiology. During 1587 patient-years of follow-up, patients with additional large-artery atherosclerosis had higher rates of the composite outcome (adjusted HR [95% CI] 1.64 [1.11, 2.40], p = 0.017) and recurrent IS (aHR 2.96 [1.65, 5.35 ], p

Published
2023
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22. sj-docx-1-eso-10.1177_23969873231185220 – Supplemental material for The impact of competing stroke etiologies in patients with atrial fibrillation

Author

Zietz, Annaelle, Polymeris, Alexandros A, Helfenstein, Fabrice, Schaedelin, Sabine, Hert, Lisa, Wagner, Benjamin, Seiffge, David J, Traenka, Christopher, Altersberger, Valerian L, Dittrich, Tolga, Kaufmann, Josefin, Ravanelli, Flavia, Fladt, Joachim, Fisch, Urs, Thilemann, Sebastian, De Marchis, Gian Marco, Gensicke, Henrik, Bonati, Leo H, Katan, Mira, Fischer, Urs, Lyrer, Philippe, Engelter, Stefan T, and Peters, Nils

Subjects
Neurology and Neuromuscular Diseases, FOS: Clinical medicine, Cardiology, Medicine
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231185220 for The impact of competing stroke etiologies in patients with atrial fibrillation by Annaelle Zietz, Alexandros A Polymeris, Fabrice Helfenstein, Sabine Schaedelin, Lisa Hert, Benjamin Wagner, David J Seiffge, Christopher Traenka, Valerian L Altersberger, Tolga Dittrich, Josefin Kaufmann, Flavia Ravanelli, Joachim Fladt, Urs Fisch, Sebastian Thilemann, Gian Marco De Marchis, Henrik Gensicke, Leo H Bonati, Mira Katan, Urs Fischer, Philippe Lyrer, Stefan T Engelter and Nils Peters in European Stroke Journal

Published
2023
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24. Global Cortical Atrophy Is Associated with an Unfavorable Outcome in Stroke Patients on Oral Anticoagulation

Author

Kubacka, Marta, primary, Zietz, Annaelle, additional, Schaedelin, Sabine, additional, Polymeris, Alexandros A., additional, Hert, Lisa, additional, Lieb, Johanna, additional, Wagner, Benjamin, additional, Seiffge, David, additional, Traenka, Christopher, additional, Altersberger, Valerian L., additional, Dittrich, Tolga, additional, Fladt, Joachim, additional, Fisch, Urs, additional, Thilemann, Sebastian, additional, De Marchis, Gian Marco, additional, Gensicke, Henrik, additional, Bonati, Leo H., additional, Lyrer, Philippe, additional, Engelter, Stefan T., additional, and Peters, Nils, additional

Published
2022
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25. Global Cortical Atrophy Is Associated with an Unfavorable Outcome in Stroke Patients on Oral Anticoagulation.

Author

Kubacka, Marta, Zietz, Annaelle, Schaedelin, Sabine, Polymeris, Alexandros A., Hert, Lisa, Lieb, Johanna, Wagner, Benjamin, Seiffge, David, Traenka, Christopher, Altersberger, Valerian L., Dittrich, Tolga, Fladt, Joachim, Fisch, Urs, Thilemann, Sebastian, De Marchis, Gian Marco, Gensicke, Henrik, Bonati, Leo H., Lyrer, Philippe, Engelter, Stefan T., and Peters, Nils

Subjects
CEREBRAL atrophy, CEREBRAL small vessel diseases, STROKE patients, ISCHEMIC stroke, CORONARY disease
Abstract

Introduction: Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and cerebral microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC) for atrial fibrillation (AF). Here, we investigated whether similar findings can be observed for global cortical atrophy (GCA). Methods: Registry-based prospective observational study of 320 patients treated with OAC following AF stroke. Patients underwent magnetic resonance imaging (MRI) allowing assessment of GCA. Using the simplified visual Pasquier scale, the severity of GCA was categorized as follows: 0: no atrophy, 1: mild atrophy; 2: moderate atrophy, and 3: severe atrophy. Using adjusted logistic and Cox regression analysis, we investigated the association of GCA using a composite outcome measure, comprising: (i) recurrent acute ischemic stroke (IS); (ii) intracranial hemorrhage (ICH); and (iii) death. Results: In our time to event analysis after adjusting for potential confounders (i.e., WMH, CMB, age, sex, diabetes, arterial hypertension, coronary heart disease, hyperlipidemia, and antiplatelet use), GCA was associated with an increased risk for the composite outcome in all three degrees of atrophy (grade 1: aHR 3.95, 95% CI 1.34–11.63, p = 0.013; grade 2: aHR 3.89, 95% CI 1.23–12.30, p = 0.021; grade 3: aHR 4.16, 95% CI 1.17–14.84, p = 0.028). Conclusion: GCA was associated with our composite outcome also after adjusting for other cSVD markers (i.e., CMB, WMH) and age, indicating that GCA may potentially serve as a prognostic marker for stroke patients with atrial fibrillation on oral anticoagulation. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Impact of type of oral anticoagulants in patients with cerebral microbleeds after atrial fibrillation-related ischemic stroke or TIA: Results of the NOACISP-LONGTERM registry

Author

Wagner, Benjamin, primary, Hert, Lisa, additional, Polymeris, Alexandros A., additional, Schaedelin, Sabine, additional, Lieb, Johanna M., additional, Seiffge, David J., additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Fladt, Joachim, additional, Altersberger, Valerian L., additional, Zietz, Annaelle, additional, Dittrich, Tolga D., additional, Fisch, Urs, additional, Gensicke, Henrik, additional, De Marchis, Gian Marco, additional, Bonati, Leo H., additional, Lyrer, Philippe A., additional, Engelter, Stefan T., additional, and Peters, Nils, additional

Published
2022
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29. Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia: A Matched Comparison

Author

Wagner, Benjamin, primary, Lorscheider, Johannes, additional, Wiencierz, Andrea, additional, Blackham, Kristine, additional, Psychogios, Marios, additional, Bolliger, Daniel, additional, De Marchis, Gian Marco, additional, Engelter, Stefan T., additional, Lyrer, Philippe, additional, Wright, Patrick R., additional, Fischer, Urs, additional, Mordasini, Pasquale, additional, Nannoni, Stefania, additional, Puccinelli, Francesco, additional, Kahles, Timo, additional, Bianco, Giovanni, additional, Carrera, Emmanuel, additional, Luft, Andreas R., additional, Cereda, Carlo W., additional, Kägi, Georg, additional, Weber, Johannes, additional, Nedeltchev, Krassen, additional, Michel, Patrik, additional, Gralla, Jan, additional, Arnold, Marcel, additional, Bonati, Leo H., additional, Anon, Javier, additional, Clarke, Sandra, additional, Diepers, Michael, additional, Gruber, Philipp, additional, Martin, Eileen, additional, Remonda, Luca, additional, Schweikert, Andreas, additional, Zupa., Vedrana, additional, Altersberger, Valerian, additional, Brehm, Alex, additional, Dittrich, Tolga, additional, El Mekabaty, Amgad, additional, Fladt, Joachim, additional, Fisch, Urs, additional, Gensicke, Henrik, additional, Hert, Lisa, additional, Manuzzi, Sabrina, additional, Maurer, Marina, additional, Meya, Louisa, additional, Peters, Nils, additional, Polymeris, Alexandros, additional, Thilemann, Sebastian, additional, Traenka, Christopher, additional, Tsogkas, Ioannes, additional, Zietz, Anaelle, additional, Goeldlin, Martina, additional, Heldner, Mirjam, additional, Jung, Simon, additional, Kaesmacher, Johannes, additional, Mamaari, Basel, additional, Meinel, Thomas, additional, Mueller, Madlaine, additional, Sarykaya, Hakan, additional, Seiffge, David, additional, Siepen, Bernhard, additional, Vynkier, Jan, additional, Eskandari, Ashraf, additional, Pantazou, Vasiliki, additional, Strambo, Davide, additional, Frangi, Jane, additional, Sihabdeen, Shairin, additional, Vehoff, Jochen, additional, Katan, Mira, additional, Mueller, Achim, additional, and Wegener, Susanne, additional

Published
2022
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30. Practical “1-2-3-4-Day” Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study

Author

Kimura, Shunsuke, primary, Toyoda, Kazunori, additional, Yoshimura, Sohei, additional, Minematsu, Kazuo, additional, Yasaka, Masahiro, additional, Paciaroni, Maurizio, additional, Werring, David J., additional, Yamagami, Hiroshi, additional, Nagao, Takehiko, additional, Yoshimura, Shinichi, additional, Polymeris, Alexandros, additional, Zietz, Annaelle, additional, Engelter, Stefan T., additional, Kallmünzer, Bernd, additional, Cappellari, Manuel, additional, Chiba, Tetsuya, additional, Yoshimoto, Takeshi, additional, Shiozawa, Masayuki, additional, Kitazono, Takanari, additional, Koga, Masatoshi, additional, Todo, Kenichi, additional, Kimura, Kazumi, additional, Yagita, Yoshiki, additional, Furui, Eisuke, additional, Itabashi, Ryo, additional, Terasaki, Tadashi, additional, Shiokawa, Yoshiaki, additional, Hirano, Teruyuki, additional, Kamiyama, Kenji, additional, Nakagawara, Jyoji, additional, Takizawa, Shunya, additional, Homma, Kazunari, additional, Okuda, Satoshi, additional, Okada, Yasushi, additional, Tokunaga, Keisuke, additional, Kameda, Tomoaki, additional, Kario, Kazuomi, additional, Nagakane, Yoshinari, additional, Hasegawa, Yasuhiro, additional, Akiyama, Hisanao, additional, Shibuya, Satoshi, additional, Mochizuki, Hiroshi, additional, Ito, Yasuhiro, additional, Nakashima, Takahiro, additional, Matsuoka, Hideki, additional, Takamatsu, Kazuhiro, additional, Nishiyama, Kazutoshi, additional, Sato, Shoichiro, additional, Arihiro, Shoji, additional, Inoue, Manabu, additional, Takagi, Masahito, additional, Tanaka, Kanta, additional, Nagatsuka, Kazuyuki, additional, Yamaguchi, Takenori, additional, Hashimoto, Yoichiro, additional, Houkin, Kiyohiro, additional, Kitagawa, Kazuo, additional, Matsumoto, Masayasu, additional, Tanahashi, Norio, additional, Terayama, Yasuo, additional, Uchiyama, Shinichiro, additional, Mori, Etsuro, additional, Furukawa, Yutaka, additional, Kimura, Takeshi, additional, Kumon, Yoshiaki, additional, Nagata, Ken, additional, Nogawa, Shigeru, additional, Sakamoto, Tomohiro, additional, Hirai, Toshinori, additional, Kudo, Kohsuke, additional, Sasaki, Makoto, additional, Kobayashi, Shotai, additional, Hamasaki, Toshimitsu, additional, Giustozzi, Michela, additional, Acciarresi, Monica, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Bandini, Fabio, additional, Tsivgoulis, Georgios, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil H, additional, Lees, Kennedy R, additional, Alberti, Andrea, additional, Venti, Michele, additional, D’Amore, Cataldo, additional, Giulia Mosconi, Maria, additional, Anna Cimini, Ludovica, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Vannucchi, Vieri, additional, Sohn, Sung-Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, Karagkiozi, Efstathia, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrissoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Galati, Franco, additional, Sacco, Simona, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Lanari, Alessia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Ulivi, Leonardo, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Tassinari, Tiziana, additional, De Lodovici, Maria Luisa, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Baronello, Mario Maimone, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, Masotti, Luca, additional, Parry-Jones, Adrian, additional, Patterson, Chris, additional, Price, Christopher, additional, Elmarimi, Abduelbaset, additional, Parry, Anthea, additional, Nallasivam, Arumug, additional, Mohd Nor, Azlisham, additional, Esis, Bernard, additional, Bruce, David, additional, Roffe, Christine, additional, Holmes, Clare, additional, Cohen, David, additional, Hargroves, David, additional, Mangion, David, additional, Chadha, Dinesh, additional, Vahidassr, Djamil, additional, Manawadu, Dulka, additional, Giallombardo, Elio, additional, Warburton, Elizabeth, additional, Flossman, Enrico, additional, Gunathilagan, Gunaratam, additional, Proschel, Harald, additional, Emsley, Hedley, additional, Anwar, Ijaz, additional, Okwera, James, additional, Putterill, Janet, additional, O’Connell, Janice, additional, Bamford, John, additional, Corrigan, John, additional, Scott, Jon, additional, Birns, Jonathan, additional, Kee, Karen, additional, Saastamoinen, Kari, additional, Pasco, Kath, additional, Dani, Krishna, additional, Sekaran, Lakshmanan, additional, Choy, Lillian, additional, Iveson, Liz, additional, Mamun, Maam, additional, Sajid, Mahmud, additional, Cooper, Martin, additional, Burn, Matthew, additional, Smith, Matthew, additional, Power, Michael, additional, Davis, Michelle, additional, Smyth, Nigel, additional, Veltkamp, Roland, additional, Sharma, Pankaj, additional, Guyler, Paul, additional, O’Mahony, Paul, additional, Wilkinson, Peter, additional, Datta, Prabel, additional, Aghoram, Prasanna, additional, Marsh, Rachel, additional, Luder, Robert, additional, Meenakishundaram, Sanjeevikumar, additional, Subramonian, Santhosh, additional, Leach, Simon, additional, Ispoglou, Sissi, additional, Andole, Sreeman, additional, England, Timothy, additional, Manoj, Aravindakshan, additional, Harrington, Frances, additional, Rehman, Habib, additional, Sword, Jane, additional, Staals, Julie, additional, Mahawish, Karim, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, McCormich, Michael, additional, Sprigg, Nikola, additional, Mansoor, Syed, additional, Krishnamurthy, Vinodh, additional, Lyrer, Philippe A, additional, Bonati, Leo H, additional, Seiffge, David J, additional, Traenka, Christopher, additional, Peters, Nils, additional, De Marchis, Gian Marco, additional, Thilemann, Sebastian, additional, Avramiotis, Nikolaos S, additional, Gensicke, Henrik, additional, Hert, Lisa, additional, Wagner, Benjamin, additional, Schaub, Fabian, additional, Meya, Louisa, additional, Fladt, Joachim, additional, Dittrich, Tolga, additional, Fisch, Urs, additional, Bonetti, Bruno, additional, Tomelleri, Giampaolo, additional, Micheletti, Nicola, additional, Zivelonghi, Cecilia, additional, Emiliani, Andrea, additional, Macha, Kosmas, additional, Siedler, Gabriela, additional, Stoll, Svenja, additional, Wang, Ruihao, additional, Volbers, Bastian, additional, Schwab, Stefan, additional, Haupenthal, David, additional, and Gaßmann, Luise, additional

Published
2022
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33. Oral Anticoagulants in Atrial Fibrillation Patients With Recent Stroke Who Are Dependent on the Daily Help of Others

Author

Meya, Louisa, primary, Polymeris, Alexandros A., additional, Schaedelin, Sabine, additional, Schaub, Fabian, additional, Altersberger, Valerian L., additional, Traenka, Christopher, additional, Thilemann, Sebastian, additional, Wagner, Benjamin, additional, Fladt, Joachim, additional, Hert, Lisa, additional, Yoshimura, Sohei, additional, Koga, Masatoshi, additional, Zietz, Annaelle, additional, Dittrich, Tolga, additional, Fisch, Urs, additional, Toyoda, Kazunori, additional, Seiffge, David J., additional, Peters, Nils, additional, De Marchis, Gian Marco, additional, Gensicke, Henrik, additional, Bonati, Leo H., additional, Lyrer, Philippe A., additional, and Engelter, Stefan T., additional

Published
2021
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35. Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial

Author

Engelter, Stefan T, primary, Traenka, Christopher, additional, Gensicke, Henrik, additional, Schaedelin, Sabine A, additional, Luft, Andreas R, additional, Simonetti, Barbara Goeggel, additional, Fischer, Urs, additional, Michel, Patrik, additional, Sirimarco, Gaia, additional, Kägi, Georg, additional, Vehoff, Jochen, additional, Nedeltchev, Krassen, additional, Kahles, Timo, additional, Kellert, Lars, additional, Rosenbaum, Sverre, additional, von Rennenberg, Regina, additional, Sztajzel, Roman, additional, Leib, Stephen L, additional, Jung, Simon, additional, Gralla, Jan, additional, Bruni, Nicole, additional, Seiffge, David, additional, Feil, Katharina, additional, Polymeris, Alexandros A, additional, Steiner, Levke, additional, Hamann, Janne, additional, Bonati, Leo H, additional, Brehm, Alex, additional, De Marchis, Gian Marco, additional, Peters, Nils, additional, Stippich, Christoph, additional, Nolte, Christian H, additional, Christensen, Hanne, additional, Wegener, Susanne, additional, Psychogios, Marios-Nikos, additional, Arnold, Marcel, additional, Lyrer, Philippe, additional, Altersberger, Valerian, additional, Engelter, Stefan T, additional, Fabbro, Thomas, additional, Fisch, Urs, additional, Fladt, Joachim, additional, Hert, Lisa, additional, Lyrer, Philippe A, additional, Maurer, Marina, additional, Polymeris, Alexandros, additional, Schaedelin, Sabine, additional, Thilemann, Sebastian, additional, Wagner, Benjamin, additional, Goeggel Simonetti, Barbara, additional, Heldner, Mirjam, additional, Seiffge, David J, additional, Mueller, Hubertus, additional, Sveikata, Lukas, additional, Correia, Pamela, additional, Eskandari, Ashraf, additional, Meyer, Ivo, additional, Nannoni, Stefania, additional, Remillard, Suzette, additional, Zachariadis, Alexandros, additional, Kaegi, Georg, additional, Mueller, Anna, additional, Erdur, Hebun J, additional, and Scheitz, Jan F, additional

Published
2021
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38. MOESM1 of Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia

Author

Fisch, Urs, Brégère, Catherine, Geier, Florian, Chicha, Laurie, and Guzman, Raphael

Subjects
nervous system
Abstract

Additional file 1: Table S1. Total numbers of animals, numbers of included animals with sex distribution and excluded animals with reason for exclusion for each experiment. Table S2. Percentages of CD11b+ CD45+ microglia per tissue group and condition for each experiment. Table S3. List of all statistical comparisons in the main figures. Figure S1. Right and left hemispheres in sham animals are not different. Figure S2. Density of PCNA+ and PAX6+ cells in the dorsolateral SVZ. Figure S3. Hypoxia alone is insufficient to elicit HI-specific microglial changes. Figure S4. SVZ microglial phagocytosis of Ki67+ SVZ cells. Figure S5. Magnetic bead sorting resulted in a high purity of CD11b+ CD45+ microglia. Figure S6. Microarray validation with qPCR for Igf-1. Figure S7. The gene expression profile of cortex and SVZ microglia after neonatal HI shared similarities with that of microglia from rodent models of neurodegenerative diseases.

Published
2020
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39. Cerebral venous thrombosis requiring invasive treatment for elevated intracranial pressure in women with combined hormonal contraceptive intake: risk factors, anatomical distribution, and clinical presentation

Author

Roethlisberger, Michel, Gut, Lara, Zumofen, Daniel Walter, Fisch, Urs, Boss, Oliver, Maldaner, Nicolai, Croci, Davide Marco, Taub, Ethan, Corti, Natascia, Burkhardt, Jan-Karl, Guzman, Raphael, Bozinov, Oliver, Mariani, Luigi, University of Zurich, and Roethlisberger, Michel

Subjects
induced hypothermia, ICP = intracranial pressure, intracranial pressure, 610 Medicine & health, cerebral venous thrombosis, GCS = Glasgow Coma Scale, 2746 Surgery, 10180 Clinic for Neurosurgery, 2728 Neurology (clinical), CHC = combined hormonal contraceptive, combined hormonal contraceptive intake, CVT = cerebral venous thrombosis, barbiturate coma, mRS = modified Rankin Scale, GOS = Glasgow Outcome Scale, decompressive surgery
Published
2018

41. Cerebral venous thrombosis requiring invasive treatment for elevated intracranial pressure in women with combined hormonal contraceptive intake: risk factors, anatomical distribution, and clinical presentation

Author

Roethlisberger, Michel, primary, Gut, Lara, additional, Zumofen, Daniel Walter, additional, Fisch, Urs, additional, Boss, Oliver, additional, Maldaner, Nicolai, additional, Croci, Davide Marco, additional, Taub, Ethan, additional, Corti, Natascia, additional, Burkhardt, Jan-Karl, additional, Guzman, Raphael, additional, Bozinov, Oliver, additional, and Mariani, Luigi, additional

Published
2018
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43. Anti-GABAAreceptor encephalitis 14 months after allogeneic haematopoietic stem-cell transplant for acute myeloid leukaemia

Author

Rusche, Thilo, Yaldizli, Özgür, Galbusera, Riccardo, Mutke, Matthias, Halter, Jörg P, Lieb, Johanna, Matteazzi, Francesca, Stelmes, Anne, Bittner, Jan, Grzonka, Pascale, Frank, Nicole, Cordier, Dominik, Hench, Jürgen, Frank, Stephan, Hirsch, Hans H, Fischer, Urs, Kuhle, Jens, Sutter, Raoul, Rüegg, Stephan, and Fisch, Urs

Published
2024
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44. Characterization of microglia in the rat subventricular zone after neonatal hypoxia-ischemia

Author

Fisch, Urs, Guzman, Raphael, and Schaeren-Wiemers, Nicole

Subjects
nervous system, animal diseases
Abstract

Background Recent findings indicate a regulatory role of microglia on neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are sought to adopt a supportive phenotype after ischemic stroke. Early postnatal microglia are endogenously activated and may therefore express an increased sensitivity to neonatal hypoxia-ischemia (HI). Therefore, we sought to investigate the impact of HI on the microglial phenotype in the early postnatal SVZ. Methods Postnatal-day (P)7 rats underwent sham or right-hemispheric HI surgery. Microglia in the SVZ, the adjacent cortex and the corpus callosum were immunohistochemically analyzed at P10, P20 and P40. Further, the transcriptome of SVZ microglia isolated at P10 and P20 was analyzed. Lastly, the effect of P10 microglia on in vitro neurosphere generation was investigated. Results The SVZ microglial response upon HI, characterized by cellular accumulation, prolonged activation and phagocytosis, is SVZ-specific and does not occur in adjacent brain regions. At the transcriptomic level, SVZ microglia adopt a complex phenotype, that resembles neither the M1 or M2 polarization state, but instead shares commonly expressed genes with microglia in neurodegenerative diseases. Finally, SVZ microglia appear to show trophic support for neurosphere generation in vitro in a concentration dependent manner. Conclusions Microglia are an inherent cellular component of the early postnatal SVZ and undergo specific developmental changes that are disrupted by neonatal HI injury. The SVZ microglial response to HI is complex and beyond a simplified pro- or anti-inflammatory phenotype. Our findings represent a solid basis for future research on SVZ microglia.

Published
2017
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45. Intravenous Thrombolysis in Patients with Stroke Taking Rivaroxaban Using Drug Specific Plasma Levels: Experience with a Standard Operation Procedure in Clinical Practice

Author

Seiffge, David J., primary, Traenka, Christopher, additional, Polymeris, Alexandros A., additional, Thilemann, Sebastian, additional, Wagner, Benjamin, additional, Hert, Lisa, additional, Müller, Mandy D., additional, Gensicke, Henrik, additional, Peters, Nils, additional, Nickel, Christian H., additional, Stippich, Christoph, additional, Sutter, Raoul, additional, Marsch, Stephan, additional, Fisch, Urs, additional, Guzman, Raphael, additional, De Marchis, Gian Marco, additional, Lyrer, Philippe A., additional, Bonati, Leo H., additional, Tsakiris, Dimitrios A., additional, and Engelter, Stefan T., additional

Published
2017
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47. Feasibility of rapid measurement of Rivaroxaban plasma levels in patients with acute stroke

Author

Seiffge, David J., primary, Traenka, Christopher, additional, Polymeris, Alexandros, additional, Hert, Lisa, additional, Fisch, Urs, additional, Peters, Nils, additional, De Marchis, Gian Marco, additional, Guzman, Raphael, additional, Nickel, Christian H., additional, Lyrer, Philipp A., additional, Bonati, Leo H., additional, Tsakiris, Dimitrios, additional, and Engelter, Stefan, additional

Published
2016
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50. Wenn das Hirn das Herz zum Stoppen bringt.

Author

Fisch, Urs

Subjects
*INSULAR cortex, *ENCEPHALITIS viruses, *HERPES simplex virus, *DELAYED diagnosis, *ANCHORING effect, *VIRAL encephalitis
Abstract

The article titled "When the Brain Stops the Heart" describes an interesting case of a patient with HSV encephalitis. The case demonstrates the anchoring effect in the diagnosis and highlights the insular cortex as a little-known brain region. Disorders of the insular cortex can lead to various symptoms, including epileptic seizures. The case also illustrates that herpes simplex virus encephalitis does not always present in a severe manner and a delayed diagnosis and treatment can be associated with a poor outcome. It is recommended to consider HSV-1 encephalitis and perform a lumbar puncture to exclude it in patients with unclear infection patterns and confusion. [Extracted from the article]

Published
2023

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