116 results on '"Firth, Mike A"'
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2. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
3. Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencing
4. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
5. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
6. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
7. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
8. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
9. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
10. Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
11. Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering
12. Optimized prime editing of the Alzheimer’s disease-associated APOE4 mutation
13. Universal toxin-based selection for precise genome engineering in human cells
14. Author Correction: Universal toxin-based selection for precise genome engineering in human cells
15. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
16. High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
17. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
18. In vivo CRISPR editing with no detectable genome-wide off-target mutations
19. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
20. BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
21. 11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015
22. Engineered Cas9 extracellular vesicles as a novel gene editing tool
23. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
24. Transformation in a Non-Strict Language: An Approach to Instantiation
25. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
26. Universal toxin-based selection for precise genome engineering in human cells
27. Supplemental_Material_GuerrieroEtAl_Computational_Analysis_of_Arrayed_CRISPR_Screens - Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
28. R2_Supplemental_Material_for_Arrayed_CRISPRCas_Screen_by_OShea_et_al – Supplemental material for A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
29. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System
30. Additional file 1: of BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
31. In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations
32. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
33. Feedback
34. Orthologue chemical space and its influence on target prediction
35. Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
36. Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis
37. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
38. Orthologue chemical space and its influence on target prediction.
39. Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective
40. Letters
41. MOLMAKER: De Novo Generation of 3D Databases for Use in Drug Design
42. Systematic Explorationof Dual-Acting Modulators froma Combined Medicinal Chemistry and Biology Perspective.
43. An incremental, exploratory and transformational environment for lazy functional programming
44. Formalised development of software by machine assisted transformation
45. Formalised development of software by machine assisted transformation.
46. MOLMAKER: De Novo Generation of 3D Databases for Use in Drug Design
47. Correction of a urea cycle defect after ex vivogene editing of human hepatocytes
48. 11th German Conference on Chemoinformatics (GCC 2015)
49. Inbox.
50. COME OUT WRITING.
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