127 results on '"Firth, Mike"'
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2. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
3. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
4. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
5. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
6. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
7. Improved nuclease-based prime editing by DNA repair modulation and pegRNA engineering
8. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
9. Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
10. Universal toxin-based selection for precise genome engineering in human cells
11. Author Correction: Universal toxin-based selection for precise genome engineering in human cells
12. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
13. High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
14. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
15. In vivo CRISPR editing with no detectable genome-wide off-target mutations
16. BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
17. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
18. 11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015
19. Engineered Cas9 extracellular vesicles as a novel gene editing tool
20. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
21. Transformation in a Non-Strict Language: An Approach to Instantiation
22. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
23. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
24. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
25. Universal toxin-based selection for precise genome engineering in human cells
26. Supplemental_Material_GuerrieroEtAl_Computational_Analysis_of_Arrayed_CRISPR_Screens - Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
27. R2_Supplemental_Material_for_Arrayed_CRISPRCas_Screen_by_OShea_et_al – Supplemental material for A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
28. Additional file 1: of BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
29. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System
30. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
31. In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations
32. Feedback
33. Orthologue chemical space and its influence on target prediction
34. Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity
35. Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis
36. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
37. Orthologue chemical space and its influence on target prediction.
38. Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective
39. Letters
40. MOLMAKER: De Novo Generation of 3D Databases for Use in Drug Design
41. Systematic Explorationof Dual-Acting Modulators froma Combined Medicinal Chemistry and Biology Perspective.
42. An incremental, exploratory and transformational environment for lazy functional programming
43. Formalised development of software by machine assisted transformation
44. Formalised development of software by machine assisted transformation.
45. Goods and Services Tax reaches a difficult age.
46. MOLMAKER: De Novo Generation of 3D Databases for Use in Drug Design
47. Correction of a urea cycle defect after ex vivogene editing of human hepatocytes
48. 11th German Conference on Chemoinformatics (GCC 2015)
49. Inbox.
50. COME OUT WRITING.
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