1. A comparative study to evaluate the efficacy of vaginal versus oral prostaglandin E1 analogue (Misoprostol) in the management of first-trimester missed abortions at a tertiary centre.
- Author
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Priyadarshini, Prerna and Jha, Richa
- Subjects
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PROSTAGLANDIN E1 , *ABORTION , *MISOPROSTOL , *FETAL development , *DRUG side effects - Abstract
Background: Missed miscarriages in the first trimester are characterised by the arrest of embryonic or foetal development with ultrasound findings of an empty gestational sac or an embryo or foetus without cardiac activity. Methods: Comparing the efficacy of misoprostol, by vaginal and oral routes, for termination of first trimester missed abortion was conducted in the department of obstetrics and gynaecology. 2 groups were made as group A and group B which had 60 participants in each group and a total of 120 participants, in which group A was given misoprostol 400 mcg orally, maximum up to 3 doses and group B was given misoprostol 400 mcg vaginally maximum up to 3 doses and outcome was documented. Primary outcome expecting drug induced complete expulsion of products of conception (POCs). Secondary outcomes measured were induction expulsion interval, number of doses required, classification of failures, cervical canal permeability in women requiring surgical evacuation, side effects. Results: Both oral and vaginal routes are highly effective (oral=73.33%, vaginal=90%, p<0.001), safe and acceptable with tolerable side effects. The mean time to expulsion was longer (11.06 hours) in the oral than vaginal group (9.05 hours). All unsuccessful cases, 2 out of 6 in vaginal group and 12 out of 16 in oral group had permeable cervices prior to surgical evacuation. Most of the side effects were tolerable in both groups. Conclusions: Vaginal route of misoprostol is more effective than oral misoprostol for first trimester missed abortion. [ABSTRACT FROM AUTHOR]
- Published
- 2024