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134 results on '"Fiorito, Silvana"'

7. Is the epithelial barrier hypothesis the key to understanding the higher incidence and excess mortality during COVID-19 pandemic? The case of Northern Italy

Author

Fiorito, Silvana; https://orcid.org/0000-0001-9006-5702, Soligo, Marzia; https://orcid.org/0000-0002-1420-0914, Gao, Yadong; https://orcid.org/0000-0003-1251-7608, Ogulur, Ismail; https://orcid.org/0000-0001-8282-7762, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Bonini, Sergio; https://orcid.org/0000-0003-0079-3031, Fiorito, Silvana; https://orcid.org/0000-0001-9006-5702, Soligo, Marzia; https://orcid.org/0000-0002-1420-0914, Gao, Yadong; https://orcid.org/0000-0003-1251-7608, Ogulur, Ismail; https://orcid.org/0000-0001-8282-7762, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, and Bonini, Sergio; https://orcid.org/0000-0003-0079-3031

Abstract

The high incidence and increased mortality of COVID-19 make Italy among the most impacted countries by SARS-CoV-2 outbreak. In the beginning of the pandemic, Northern regions accounted for 40% of cases and 45% of deaths from COVID-19 in Italy. Several factors have been suggested to explain the higher incidence and excess mortality from COVID-19 in these regions. It is noticed that Northern Italian regions, and particularly the cities in Po Valley, are the areas with the highest air pollution due to commercial vehicle traffic, industry and a stagnant meteorological condition, with one of the highest levels in Italy and Europe of fine particulate matter 2.5 micron or smaller in size (PM2.5). PM2.5, the major environmental pollutant deriving mainly by factory and automobile exhaust emissions and coal combustion, increases the expression of angiotensin-converting enzyme 2, the epithelial cell entry receptor for SARS-CoV-2, and thus increase the susceptibility to this virus. The epithelial barrier hypothesis proposes that many diverse diseases may rise from the disruption of epithelial barrier of skin, respiratory tract and gastrointestinal system, including allergic diseases, metabolic and autoimmune diseases, and chronic neuropsychiatric conditions. There is evidence of a close correlation between air pollution and airway epithelial barrier dysfunction. Air pollution, causing lung epithelial barrier dysfunction, may contribute to local chronic inflammation, microbiome dysbiosis and impaired antiviral immune response against SARS-CoV-2, all of which contribute to the high incidence and excess mortality from COVID-19. In addition, air pollution and epithelial barrier dysfunction contribute also to the higher prevalence of several comorbidities of COVID-19, such as diabetes, chronic obstructive pulmonary disease and obesity, which have been identified as risk factors for mortality of COVID-19. In this article, on the basis of epidemiological and environmental monitoring d

Published
2022

13. Association Between Metabolic and Hormonal Derangements and Professional Exposure to Urban Pollution in a High Intensity Traffic Area

Author

Molfino, Alessio, primary, Amabile, Maria Ida, additional, Muscaritoli, Maurizio, additional, Germano, Annunziata, additional, Alfano, Rossella, additional, Ramaccini, Cesarina, additional, Spagnoli, Alessandra, additional, Cavaliere, Liberato, additional, Marseglia, Gianluca, additional, Nardone, Antonio, additional, Muto, Giuseppina, additional, Carbone, Umberto, additional, Triassi, Maria, additional, and Fiorito, Silvana, additional

Published
2020
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17. Diesel exhaust particles induce autophagy and citrullination in Normal Human Bronchial Epithelial cells

Author

Colasanti, Tania, primary, Fiorito, Silvana, additional, Alessandri, Cristiano, additional, Serafino, Annalucia, additional, Andreola, Federica, additional, Barbati, Cristiana, additional, Morello, Francesca, additional, Alfè, Michela, additional, Di Blasio, Gabriele, additional, Gargiulo, Valentina, additional, Vomero, Marta, additional, Conti, Fabrizio, additional, and Valesini, Guido, additional

Published
2018
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18. Switching on microglia with electro-conductive multi walled carbon nanotubes

Author

Fiorito, Silvana, primary, Russier, Julie, additional, Salemme, Adele, additional, Soligo, Marzia, additional, Manni, Luigi, additional, Krasnowska, Ewa, additional, Bonnamy, Sylvie, additional, Flahaut, Emmanuel, additional, Serafino, Annalucia, additional, Togna, Giuseppina Ines, additional, Marlier, Lionel N.J.L., additional, and Togna, Anna Rita, additional

Published
2018
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24. Supplementing π-systems: eumelanin and graphene-like integration towards highly conductive materials for the mammalian cell culture bio-interface

Author

Gargiulo, Valentina, primary, Alfè, Michela, additional, Capua, Roberto Di, additional, Togna, Anna Rita, additional, Cammisotto, Vittoria, additional, Fiorito, Silvana, additional, Musto, Anna, additional, Navarra, Angelica, additional, Parisi, Silvia, additional, and Pezzella, Alessandro, additional

Published
2015
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39. Biocompatibility and applications of carbon nanotubes in medical nanorobots

Author

Popov, Andrei M, Lozovik, Yurii E, Fiorito, Silvana, and Yahia, L’Hocine

Subjects
Technology Assessment, Biomedical, Nanotubes, Carbon, Transducers, Biocompatible Materials, Review, Biosensing Techniques, Equipment Design, Robotics, Nanothermometer, Nanotube, NEMS, Nanomedicine, Equipment and Supplies, Biocompatibility, Nanorobot
Abstract

The set of nanoelectromechanical systems (NEMS) based on relative motion of carbon nanotubes walls is proposed for use in medical nanorobots. This set includes electromechanical nanothermometer, jet nanoengine, nanosyringe (the last can be used simultaneously as nanoprobe for individual biological molecules and drug nanodeliver). Principal schemes of these NEMS are considered. Operational characteristics of nanothermometer are analyzed. The possible methods of these NEMS actuation are considered. The present-day progress in nanotechnology techniques which are necessary for assembling of NEMS under consideration is discussed. Biocompatibility of carbon nanotubes is analyzed in connection with perspectives of their application in nanomedicine.

Published
2007

48. Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function

Author

Pierdominici, Marina, primary, Maselli, Angela, additional, Cecchetti, Serena, additional, Tinari, Antonella, additional, Mastrofrancesco, Arianna, additional, Alfè, Michela, additional, Gargiulo, Valentina, additional, Beatrice, Carlo, additional, Di Blasio, Gabriele, additional, Carpinelli, Giulia, additional, Ortona, Elena, additional, Giovannetti, Antonello, additional, and Fiorito, Silvana, additional

Published
2014
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