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1. Organization and Activity of Italian Echocardiographic Laboratories: A Survey of the Italian Society of Echocardiography and Cardiovascular Imaging

Author

Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., Carerj S., Ciampi, Q, Pepi, M, Antonini-Canterin, F, Barbieri, A, Barchitta, A, Faganello, G, Miceli, S, Parato, V, Tota, A, Trocino, G, Abbate, M, Accadia, M, Alemanni, R, Angelini, A, Anglano, F, Anselmi, M, Aquila, I, Aramu, S, Avogadri, E, Azzaro, G, Badano, L, Balducci, A, Ballocca, F, Barbarossa, A, Barbati, G, Barletta, V, Barone, D, Becherini, F, Benfari, G, Beraldi, M, Bergandi, G, Bilardo, G, Binno, S, Bolognesi, M, Bongiovi, S, Bragato, R, Braggion, G, Brancaleoni, R, Bursi, F, Dessalvi, C, Cameli, M, Canu, A, Capitelli, M, Capra, A, Carbonara, R, Carbone, M, Carbonella, M, Carrabba, N, Casavecchia, G, Casula, M, Chesi, E, Cicco, S, Citro, R, Cocchia, R, Colombo, B, Colonna, P, Conte, M, Corrado, G, Cortesi, P, Cortigiani, L, Costantino, M, Cozza, F, Cucchini, U, D'Angelo, M, Ros, S, D'Andrea, F, D'Andrea, A, D'Auria, F, De Caridi, G, De Feo, S, De Matteis, G, De Vecchi, S, Del Giudice, C, Dell'Angela, L, Delli Paoli, L, Dentamaro, I, Destefanis, P, Di Fulvio, M, Di Gaetano, R, Di Giannuario, G, Di Gioia, A, Di Martino, L, Di Muro, C, Di Nora, C, Di Salvo, G, Dodi, C, Dogliani, S, Donati, F, Dottori, M, Epifani, G, Fabiani, I, Ferrara, F, Ferrara, L, Ferrua, S, Filice, G, Fiorino, M, Forno, D, Garini, A, Giarratana, G, Gigantino, G, Giorgi, M, Giubertoni, E, Greco, C, Grigolato, M, Marra, W, Holzl, A, Iaiza, A, Iannaccone, A, Ilardi, F, Imbalzano, E, Inciardi, R, Inserra, C, Iori, E, Izzo, A, La Rosa, G, Labanti, G, Lanzone, A, Lanzoni, L, Lapetina, O, Leiballi, E, Librera, M, Lo Conte, C, Lo Monaco, M, Lombardo, A, Luciani, M, Lusardi, P, Magnante, A, Malagoli, A, Malatesta, G, Mancusi, C, Manes, M, Manganelli, F, Mantovani, F, Manuppelli, V, Marchese, V, Marinacci, L, Mattioli, R, Maurizio, C, Mazza, G, Mazza, S, Melis, M, Meloni, G, Merli, E, Milan, A, Minardi, G, Monaco, A, Monte, I, Montresor, G, Moreo, A, Mori, F, Morini, S, Moro, C, Morrone, D, Negri, F, Nipote, C, Nisi, F, Nocco, S, Novello, L, Nunziata, L, Perini, A, Parodi, A, Pasanisi, E, Pastorini, G, Pavasini, R, Pavoni, D, Pedone, C, Pelliccia, F, Pelliciari, G, Pelloni, E, Pergola, V, Perillo, G, Petruccelli, E, Pezzullo, C, Piacentini, G, Picardi, E, Pinna, G, Pizzarelli, M, Pizzuti, A, Poggi, M, Posteraro, A, Privitera, C, Rampazzo, D, Ratti, C, Rettegno, S, Ricci, F, Ricci, C, Rolando, C, Rossi, S, Rovera, C, Ruggieri, R, Russo, M, Sacchi, N, Saladino, A, Sani, F, Sartori, C, Scarabeo, V, Sciacqua, A, Scillone, A, Scopelliti, P, Scorza, A, Scozzafava, A, Serafini, F, Serra, W, Severino, S, Simeone, B, Sirico, D, Solari, M, Spadaro, G, Stefani, L, Strangio, A, Surace, F, Tamborini, G, Tarquinio, N, Tassone, E, Tavarozzi, I, Tchana, B, Tedesco, G, Tinto, M, Torzillo, D, Totaro, A, Triolo, O, Troisi, F, Tusa, M, Vancheri, F, Varasano, V, Venezia, A, Vermi, A, Villari, B, Zampi, G, Zannoni, J, Zito, C, Zugaro, A, Di Bella, G, Carerj, S, Ciampi Q., Pepi M., Antonini-Canterin F., Barbieri A., Barchitta A., Faganello G., Miceli S., Parato V. M., Tota A., Trocino G., Abbate M., Accadia M., Alemanni R., Angelini A., Anglano F., Anselmi M., Aquila I., Aramu S., Avogadri E., Azzaro G., Badano L., Balducci A., Ballocca F., Barbarossa A., Barbati G., Barletta V., Barone D., Becherini F., Benfari G., Beraldi M., Bergandi G., Bilardo G., Binno S. M., Bolognesi M., Bongiovi S., Bragato R. M., Braggion G., Brancaleoni R., Bursi F., Dessalvi C. C., Cameli M., Canu A., Capitelli M., Capra A. C. M., Carbonara R., Carbone M., Carbonella M., Carrabba N., Casavecchia G., Casula M., Chesi E., Cicco S., Citro R., Cocchia R., Colombo B. M., Colonna P., Conte M., Corrado G., Cortesi P., Cortigiani L., Costantino M. F., Cozza F., Cucchini U., D'Angelo M., Ros S. D., D'Andrea F., D'Andrea A., D'Auria F., De Caridi G., De Feo S., De Matteis G. M., De Vecchi S., Del Giudice C., Dell'Angela L., Delli Paoli L., Dentamaro I., Destefanis P., Di Fulvio M., Di Gaetano R., Di Giannuario G., Di Gioia A., Di Martino L. F. M., Di Muro C., Di Nora C., Di Salvo G., Dodi C., Dogliani S., Donati F., Dottori M., Epifani G., Fabiani I., Ferrara F., Ferrara L., Ferrua S., Filice G., Fiorino M., Forno D., Garini A., Giarratana G. A., Gigantino G., Giorgi M., Giubertoni E., Greco C. A., Grigolato M., Marra W. G., Holzl A., Iaiza A., Iannaccone A., Ilardi F., Imbalzano E., Inciardi R., Inserra C. A., Iori E., Izzo A., La Rosa G., Labanti G., Lanzone A. M., Lanzoni L., Lapetina O., Leiballi E., Librera M., Lo Conte C., Lo Monaco M., Lombardo A., Luciani M., Lusardi P., Magnante A., Malagoli A., Malatesta G., Mancusi C., Manes M. T., Manganelli F., Mantovani F., Manuppelli V., Marchese V., Marinacci L., Mattioli R., Maurizio C., Mazza G. A., Mazza S., Melis M., Meloni G., Merli E., Milan A., Minardi G., Monaco A., Monte I., Montresor G., Moreo A., Mori F., Morini S., Moro C., Morrone D., Negri F., Nipote C., Nisi F., Nocco S., Novello L., Nunziata L., Perini A. P., Parodi A., Pasanisi E. M., Pastorini G., Pavasini R., Pavoni D., Pedone C., Pelliccia F., Pelliciari G., Pelloni E., Pergola V., Perillo G., Petruccelli E., Pezzullo C., Piacentini G., Picardi E., Pinna G., Pizzarelli M., Pizzuti A., Poggi M. M., Posteraro A., Privitera C., Rampazzo D., Ratti C., Rettegno S., Ricci F., Ricci C., Rolando C., Rossi S., Rovera C., Ruggieri R., Russo M. G., Sacchi N., Saladino A., Sani F., Sartori C., Scarabeo V., Sciacqua A., Scillone A., Scopelliti P. A., Scorza A., Scozzafava A., Serafini F., Serra W., Severino S., Simeone B., Sirico D., Solari M., Spadaro G. L., Stefani L., Strangio A., Surace F. C., Tamborini G., Tarquinio N., Tassone E. J., Tavarozzi I., Tchana B., Tedesco G., Tinto M., Torzillo D., Totaro A., Triolo O. F., Troisi F., Tusa M., Vancheri F., Varasano V., Venezia A., Vermi A. C., Villari B., Zampi G., Zannoni J., Zito C., Zugaro A., Di Bella G., and Carerj S.

Abstract

Background: The Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI) conducted a national survey to understand better how different echocardiographic modalities are used and accessed in Italy. Methods: We analyzed echocardiography laboratory activities over a month (November 2022). Data were retrieved via an electronic survey based on a structured questionnaire, uploaded on the SIECVI website. Results: Data were obtained from 228 echocardiographic laboratories: 112 centers (49%) in the northern, 43 centers (19%) in the central, and 73 (32%) in the southern regions. During the month of observation, we collected 101,050 transthoracic echocardiography (TTE) examinations performed in all centers. As concern other modalities there were performed 5497 transesophageal echocardiography (TEE) examinations in 161/228 centers (71%); 4057 stress echocardiography (SE) examinations in 179/228 centers (79%); and examinations with ultrasound contrast agents (UCAs) in 151/228 centers (66%). We did not find significant regional variations between the different modalities. The usage of picture archiving and communication system (PACS) was significantly higher in the northern (84%) versus central (49%) and southern (45%) centers (P < 0.001). Lung ultrasound (LUS) was performed in 154 centers (66%), without difference between cardiology and noncardiology centers. The evaluation of left ventricular (LV) ejection fraction was evaluated mainly using the qualitative method in 223 centers (94%), occasionally with the Simpson method in 193 centers (85%), and with selective use of the three-dimensional (3D) method in only 23 centers (10%). 3D TTE was present in 137 centers (70%), and 3D TEE in all centers where TEE was done (71%). The assessment of LV diastolic function was done routinely in 80% of the centers. Right ventricular function was evaluated using tricuspid annular plane systolic excursion in all centers, using tricuspid valve annular systolic velocity by tissue

Published
2023

2. Violence and dementia

Author

Cipriani, G., primary, Danti, S., additional, Nuti, A., additional, Picchi, L., additional, and Di Fiorino, M., additional

Published
2020
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3. Contributors

Author

Aboseif, Albert, primary, Alessandro, Morandi, additional, Alquézar, Carolina, additional, Anderson, Rachel, additional, Andolf, Ellika, additional, Andreeva, Tatiana, additional, Ano, Yasuhisa, additional, Araki, Yuko, additional, Arroyo-Anlló, Eva M., additional, Ayabe, Tatsuhiro, additional, Bae, Mi Ae, additional, Bakulski, Kelly M., additional, Balcar, Vladimir J., additional, Baldassarro, Vito Antonio, additional, Battista, Petronilla, additional, Bellomo, Antonello, additional, Bednarska-Makaruk, Małgorzata, additional, Benzinger, Tammie L., additional, Berkowitz, Laura E., additional, Berumen, L.C., additional, Bighinati, Andrea, additional, Brodtmann, Amy, additional, Budni, Josiane, additional, Calzà, Laura, additional, Capozzo, Rosa, additional, Caramelli, Paulo, additional, Cardoso, Barbara R., additional, Carr, Jessie S., additional, Carrasco, Javier, additional, Chang, J.W., additional, Chang, Kyung Ja, additional, Chen, Lu Hua, additional, Cheng, Sheung-Tak, additional, Christian, Pozzi, additional, Chu, Leung Wing, additional, Cipriani, G., additional, Clark, Benjamin J., additional, Comes, Gemma, additional, Coppedè, Fabio, additional, Cuadrado-Tejedor, Mar, additional, D'Acunto, Emanuela, additional, Daniele, Antonio, additional, Danti, S., additional, De Jaco, Antonella, additional, de la Torre, Rafael, additional, Di Fiorino, M., additional, Eleonora, Grossi, additional, Endres, Kristina, additional, Escrig, Anna, additional, Farese, Robert V., additional, Fernández-Gayol, Olaya, additional, Fokin, Vitaly, additional, Frenkel, Dan, additional, Fu, Wen, additional, Galliciotti, Giovanna, additional, García-Alcocer, G., additional, Garcia-Osta, Ana, additional, Giardino, Luciana, additional, Gil, Roger, additional, Giralt, Mercedes, additional, Giuseppe, Bellelli, additional, Gomes, Karina Braga, additional, Gonçalves-Pereira, Manuel, additional, González-Gómez, Miriam, additional, Goswami, Nandu, additional, Gottlieb, Elie, additional, Greco, Antonio, additional, Grillo, Dorothy M., additional, Grima, Natalie A., additional, Griseta, Chiara, additional, Guilherme, Malena dos Santos, additional, Harvey, Ryan E., additional, Hashimoto, Manabu, additional, Herrmann, Nathan, additional, Hertzog da Silva Leme, Adriana Gisele, additional, Hibino, Emi, additional, Hidalgo, Juan, additional, Howard, Mark, additional, Hu, Howard, additional, Illarioshkin, Sergey, additional, Inestrosa, Nibaldo C., additional, Jhamandas, Jack H., additional, Khan, Amber, additional, La Montagna, Maddalena, additional, Lanctôt, Krista L., additional, Laskowska-Kaszub, Katarzyna, additional, Lee, Han-Kyu, additional, Liu, Lei, additional, Liu, Celina S., additional, Llorente-Ovejero, Alberto, additional, Logroscino, Giancarlo, additional, Lombardero, Laura, additional, Lozano, Stephanie, additional, Lozupone, Madia, additional, Manso, Yasmina, additional, Manuel, Iván, additional, Marin, Raquel, additional, Martín-Requero, Ángeles, additional, Martino Adami, Pamela V., additional, Mendiola-Precoma, J., additional, Miranda, Elena, additional, Mitsuishi, Yachiyo, additional, Molinero, Amalia, additional, Morelli, Laura, additional, Morris, John C., additional, Murphy, Kelsey E., additional, Nakano, Masaki, additional, Nagaraj, Siranjeevi, additional, Nash, Yuval, additional, Nishimura, Masaki, additional, Nuti, A., additional, de Oliveira, Jade, additional, Panza, Francesco, additional, Park, Joshua J., additional, Park, Y.S., additional, Park, Sung Kyun, additional, Pase, Matthew P., additional, Picchi, L., additional, Ponomareva, Natalya, additional, Poole, Matthew L., additional, Preedy, Victor R., additional, Puertas-Avendaño, Ricardo, additional, Querfurth, Henry, additional, Quinto-Alemany, David, additional, Ravic de Miranda, Luís Felipe José, additional, Rajendram, Rajkumar, additional, Resta, Onofrio, additional, Reinhardt, Sven, additional, Rodríguez-Cruz, A., additional, Rodríguez-Puertas, Rafael, additional, Rogaev, Evgeny, additional, Rosen, Michael, additional, Sajan, Mini P., additional, Sanchis, Paula, additional, Sannia, Michele, additional, Sardone, Rodolfo, additional, Sasaki, Makoto, additional, Sepulveda-Falla, Diego, additional, Seripa, Davide, additional, Šerý, Omar, additional, Sirkis, Daniel W., additional, Song, You-Qiang, additional, Su, Brenda Bin, additional, Sugi, Takuma, additional, Villaseca, Paulina, additional, Vogel, Adam P., additional, Walker, Douglas Gordon, additional, Wang, Hoau-Yan, additional, Wang, Kesheng, additional, Watanabe, Naoki, additional, Weidman, David, additional, Wojda, Urszula, additional, Woo, Benjamin K.P., additional, Xicota, Laura, additional, Xu, Chun, additional, Yablonskiy, Dmitriy A., additional, Yamashita, Fumio, additional, Yao, Hiroshi, additional, Yokoyama, Jennifer S., additional, Zhang, Fan, additional, Zolezzi, Juan M., additional, and Zoltowska, Katarzyn Marta, additional

Published
2020
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4. Causes of Ocean Surface temperature Changes in Atlantic and Pacific Topical Cyclogenesis Regions

Author

Santer, B.D., Wigley, T.M.L., Gleckler, P.J., Bonfils, C., Wehner, M.F., AchutaRao, K., Barnett, T.P., Boyle, J.S., Bruggemann, W., Fiorino, M., Gillett, N., Hansen, J.E., Jones, P.D., Klein, S.A., Meehl, G.A., Raper, S.C.B., Reynolds, R.W., Stott, P.A., Taylor, K.E., and Washington, W.M.

Subjects
General and miscellaneous//mathematics, computing, and information science
Published
2006

6. Utility of a buccal swab point-of-care test for the IFNL4 genotype in the era of direct acting antivirals for hepatitis C virus

Author

Sy, A, McCabe, L, Hudson, E, Ansari, AM, Pedergnana, V, Lin, S-K, Santana, S, Fiorino, M, Ala, A, Stone, B, Smith, M, Nelson, M, Barclay, ST, McPherson, S, Ryder, SD, Collier, J, Barnes, E, Walker, AS, Pett, SL, Cooke, G, STOP-HCV-1 trial team, and team, STOP-HCV-1 trial

Subjects
Multidisciplinary
Abstract

Background The CC genotype of the IFNL4 gene is known to be associated with increased Hepatitis C (HCV) cure rates with interferon-based therapy and may contribute to cure with direct acting antivirals. The Genedrive® IFNL4 is a CE marked Point of Care (PoC) molecular diagnostic test, designed for in vitro diagnostic use to provide rapid, real-time detection of IFNL4 genotype status for SNP rs12979860. Methods 120 Participants were consented to a substudy comparing IFNL4 genotyping results from a buccal swab analysed on the Genedrive® platform with results generated using the Affymetix UK Biobank array considered to be the gold standard. Results Buccal swabs were taken from 120 participants for PoC IFNL4 testing and a whole blood sample for genetic sequencing. Whole blood genotyping vs. buccal swab PoC testing identified 40 (33%), 65 (54%), and 15 (13%) had CC, CT and TT IFNL4 genotype respectively. The Buccal swab PoC identified 38 (32%) CC, 64 (53%) CT and 18 (15%) TT IFNL4 genotype respectively. The sensitivity and specificity of the buccal swab test to detect CC vs non-CC was 90% (95% CI 76–97%) and 98% (95% CI 91–100%) respectively. Conclusions The buccal swab test was better at correctly identifying non-CC genotypes than CC genotypes. The high specificity of the Genedrive® assay prevents CT/TT genotypes being mistaken for CC, and could avoid patients being identified as potentially ‘good responders’ to interferon-based therapy.

Published
2023

9. Correction to: Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR) (BMC Surgery, (2020), 20, 1, (251), 10.1186/s12893-020-00914-5)

Author

Gallo G., Di Saverio S., Clerico G., Sturiale A., Manigrasso M., Luc A. R., Trompetto M., Sammarco G., Ferrari F., Carpino A., Sena G., Vescio G., Stratta E., Tonello P., Cornaglia S., Greco V., Talarico C., Tutino R., Falco N., Venturelli P., Cocorullo G., Pietroletti R., Rizza V., Milito G., Campanelli M., Lisi G., Brachitta S., Cavallaro V., Pecorella G., Turri B., Sasia D., Giuffrida M. C., Milone M., Palma G. D., Bianco V., Moggia E., Talamo G., Oggianu A., Pili M., Palumbo A., Fazio M., Aiello D., Bianco F., Bondurri A., La Torre M., Mancini S., Perinotti R., Serventi A., Fiorino M., Gallo G., Di Saverio S., Clerico G., Sturiale A., Manigrasso M., Luc A.R., Trompetto M., Sammarco G., Ferrari F., Carpino A., Sena G., Vescio G., Stratta E., Tonello P., Cornaglia S., Greco V., Talarico C., Tutino R., Falco N., Venturelli P., Cocorullo G., Pietroletti R., Rizza V., Milito G., Campanelli M., Lisi G., Brachitta S., Cavallaro V., Pecorella G., Turri B., Sasia D., Giuffrida M.C., Milone M., Palma G.D., Bianco V., Moggia E., Talamo G., Oggianu A., Pili M., Palumbo A., Fazio M., Aiello D., Bianco F., Bondurri A., La Torre M., Mancini S., Perinotti R., Serventi A., Fiorino M., Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G. D., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., La Torre, M., Mancini, S., Perinotti, R., Serventi, A., and Fiorino, M.

Subjects
Emtree
Abstract

An amendment to this paper has been published and can be accessed via the original article.

Published
2020

10. La scintigraphie osseuse Veriton : un nouvel outil prometteur dans le diagnostic de sacro-iliite inflammatoire.

Author

Fiorino, M., Caroline, M., Loeuille, D., and Chary-Valckenaere, I.

Abstract

L'objectif de notre étude est d'étudier l'intérêt de la scintigraphie osseuse Veriton (SO-Ver) corps entier dans l'évaluation et le diagnostic de sacroiliite inflammatoire, en comparaison à l'IRM. Au total, 78 patients consécutifs suspects de rhumatisme inflammatoire chronique ayant bénéficié d'une SO-Ver ont été inclus entre novembre 2021 et février 2023. Seuls les patients ayant bénéficié d'une IRM des sacro-iliaques dans le mois ont été inclus et classés en 2 groupes : spondyloarthrite axiale (SpA) et non-spondyloarthrite (non-SpA). La présence/l'absence de sacroiliite, en IRM (définie selon les critères ASAS) puis en SO-Ver aux temps précoce (TP) et tardif (TT), a été établie. Des analyses quantitatives des articulations sacro-iliaques ont également été réalisées, en SO-Ver en utilisant les SUV maximums et normalisés (TP et TT), en IRM par la réalisation de scores SPARCC, par deux paires de lecteurs indépendants et en aveugle des données patients. Au total, 47 patients ont été répartis dans les 2 groupes (25 dans le groupe SpA et 22 dans le groupe non-SpA). En SO-Ver, une sacroiliite a été retrouvée chez 7/25 (28 %) et 8/25 (32 %) patients dans le groupe SpA, comparé à 0/22 et 6/22 (27 %) patients dans le groupe Non-SpA, en TP et TT respectivement. Une sacro-iliite IRM a été observée chez 16/25 (64 %) et 11/22 (50 %) patients dans les groupes SpA et non-SpA respectivement. Pour le diagnostic de sacroiliite inflammatoire la SO-Ver présente une sensibilité de 28 % (14–47) et 32 % (17–51) et une spécificité de 100 % (82–100) et 72 % (51–87) en TP et TT respectivement. En IRM la sensibilité et la spécificité sont de 64 % (44–79) et 50 % (30–69) pour le diagnostic de sacroiliite. En analyse binaire, l'IRM était associée à la SO-Ver uniquement en TT (OR [95 %CI] = 5,5 [1,9–16,3]). Les scores SPARCC étaient corrélés aux SUV maximums en TP (valeur 0,41 ; p < 0,0001) et en TT (valeur 0,53 ; p < 0,0001). Les SUV maximums (TT) et les scores SPARCC étaient plus élevés chez les patients souffrant de douleurs sacro-iliaques (p = 0,002 et p = 0,026, respectivement). Seul le SUV normalisé en TP était associé à une CRP élevée (p = 0,012). Il s'agit de la 1re étude visant à évaluer les performances diagnostiques de la SO-Ver dans l'évaluation de la sacro-iliite inflammatoire. L'IRM reste l'examen de référence dans cette indication mais présente des limites que la SO-Ver peut espérer surpasser. L'IRM des sacro-iliaques a notamment conduit à de nombreux faux-positifs, en particulier en post-partum ou chez les patients sportifs. Les lésions inflammatoires évocatrices de spondyloarthrite à l'IRM augmentent avec l'âge, suggérant le rôle de facteurs dégénératifs (arthrosiques). Dans notre étude, aucun patient du groupe non-SpA n'a présenté de sacro-iliite en SO-Ver en TP, témoignant de son excellente spécificité. La SO-Ver présente une bonne corrélation avec l'IRM pour l'évaluation de la sacroiliite inflammatoire dans la spondylarthrite axiale. Une sacroiliite en So-Ver présente un niveau de spécificité supérieur à celle de l'IRM alors que la sensibilité est plus faible. En outre, au temps tardif, les SUV maximums étaient associés à la présence d'une douleur sacro-iliaque. Ces résultats prometteurs devront être confirmés dans des études futures. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Mesoglycan for pain control after open excisional HAEMOrrhoidectomy (MeHAEMO): an observational multicentre study on behalf of the Italian Society of Colorectal Surgery (SICCR)

Author

Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., Fiorino, M., Gallo, G., Di Saverio, S., Clerico, G., Sturiale, A., Manigrasso, M., Luc, A. R., Trompetto, M., Sammarco, G., Ferrari, F., Carpino, A., Sena, G., Vescio, G., Stratta, E., Tonello, P., Cornaglia, S., Greco, V., Talarico, C., Tutino, R., Falco, N., Venturelli, P., Cocorullo, G., Pietroletti, R., Rizza, V., Milito, G., Campanelli, M., Lisi, G., Brachitta, S., Cavallaro, V., Pecorella, G., Turri, B., Sasia, D., Giuffrida, M. C., Milone, M., Palma, G., Bianco, V., Moggia, E., Talamo, G., Oggianu, A., Pili, M., Palumbo, A., Fazio, M., Aiello, D., Bianco, F., Bondurri, A., Torre, M., Macini, S., Perinotti, R., Serventi, A., and Fiorino, M.

Subjects
Male, medicine.medical_treatment, haemorrhoidal disease, post-operative pain, open excisional haemorrhoidectomy, mesoglycan, thrombosis, mucocutaneous bridges, Open excisional haemorrhoidectomy, Haemorrhoidal disease, Mesoglycan, Mucocutaneous bridges, Post-operative pain, Thrombosis, Mucocutaneous bridge, Retrospective Studie, 80 and over, Glycosaminoglycans, Aged, 80 and over, Pain, Postoperative, Fibrinolytic Agent, General Medicine, Middle Aged, Colorectal surgery, Treatment Outcome, Thrombosi, Female, Human, Research Article, Adult, Hemorrhoidectomy, medicine.medical_specialty, lcsh:Surgery, Pain, Hemorrhoids, Young Adult, Pain control, Fibrinolytic Agents, medicine, Humans, Postoperative, Aged, Retrospective Studies, business.industry, Gold standard, Correction, Diathermy, lcsh:RD1-811, medicine.disease, Surgery, Glycosaminoglycan, Defecation, Observational study, business, Hemorrhoid
Abstract

Background Excisional haemorrhoidectomy is the gold standard technique in patients with III and IV degree haemorrhoidal disease (HD). However, it is associated with a significant rate of post-operative pain. The aim of our study was to evaluate the efficacy of mesoglycan in the post-operative period of patients who underwent open excisional diathermy haemorrhoidectomy (OEH). Methods This was a retrospective multicentre observational study. Three hundred ninety-eight patients from sixteen colorectal referral centres who underwent OEH for III and IV HD were enrolled. All patients were followed-up on the first post-operative day (T1) and after 1 week (T2), 3 weeks (T3) and 6 weeks (T4). BMI, habits, SF-12 questionnaire, VAS at rest (VASs), after defecation (VASd), and after anorectal digital examination (VASe), bleeding and thrombosis, time to surgical wound healing and autonomy were evaluated. Results In the mesoglycan group, post-operative thrombosis was significantly reduced at T2 (p Conclusions The use of mesoglycan led to a significant reduction in post-operative thrombosis and pain with consequent early resumption of autonomy. Trial registration NCT04481698—Mesoglycan for Pain Control After Open Excisional HAEMOrrhoidectomy (MeHAEMO) https://clinicaltrials.gov/ct2/show/NCT04481698?term=Mesoglycan+for+Pain+Control+After+Open+Excisional+HAEMOrrhoidectomy+%28MeHAEMO%29&draw=2&rank=1

Published
2020

12. NCEP–DOE AMIP-II REANALYSIS (R-2)

Author

Kanamitsu, Masao, Ebisuzaki, Wesley, Woollen, Jack, Yang, Shi-Keng, Hnilo, J. J., Fiorino, M., and Potter, G. L.

Published
2002

13. The GCM-Reality Intercomparison Project for SPARC (GRIPS) : Scientific Issues and Initial Results

Author

Pawson, S., Kodera, K., Hamilton, K., Shepherd, T. G., Beagley, S. R., Boville, B. A., Farrara, J. D., Fairlie, T. D. A., Kitoh, A., Lahoz, W. A., Langematz, U., Manzini, E., Rind, D. H., Scaife, A. A., Shibata, K., Simon, P., Swinbank, R., Takacs, L., Wilson, R. J., Al-Saadi, J. A., Amodei, M., Chiba, M., Coy, L., de Grandpré, J., Eckman, R. S., Fiorino, M., Grose, W. L., Koide, H., Koshyk, J. N., Li, D., Lerner, J., Mahlman, J. D., McFarlane, N. A., Mechoso, C. R., Molod, A., O’Neill, A., Pierce, R. B., Randel, W. J., Rood, R. B., and Wu, F.

Published
2000

14. A nationwide audit of the use of radiotherapy for rectal cancer in Italy

Author

Gagliardi, G., Pucciarelli, S., Asteria, C. R., Infantino, A., Romano, G., Cola, B., De Nardi, P., Brulatti, M., Lambertini, M., Contessini-Avesani, E., Casula, G., Coco, C., D’Amico, D., Selvaggi, F. F., Eccher, C., D’Ambrosio, G., Galeotti, F., Jovine, E., Demma, I., Fianchini, A., Ambrosino, G., Casentino, L. M., and Fiorino, M.

Published
2010
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16. CD4 CD45RB T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin

Author

Byrne, F.R., Morony, S., Warmington, K., Geng, Z., Brown, H.L., Flores, S.A., Fiorino, M., Yin, S.L., Hill, D., Porkess, V., Duryea, D., Pretorius, J.K., Adamu, S., Manuokian, R., Danilenko, D.M., Sarosi, I., Lacey, D.L., Kostenuik, P.J., and Senaldi, G.

Subjects
Osteoporosis -- Care and treatment, Osteoporosis -- Risk factors, Inflammatory bowel diseases -- Research, Inflammatory bowel diseases -- Care and treatment, Inflammatory bowel diseases -- Complications, Health
Published
2005

19. Quality control of B-lines analysis in stress Echo 2020

Author

Scali, M. C., Ciampi, Q., Picano, E., Bossone, E., Ferrara, F., Citro, R., Colonna, P., Costantino, M. F., Cortigiani, L., Andrea, A. D., Severino, S., Dodi, C., Gaibazzi, N., Galderisi, M., Barbieri, A., Monte, I., Mori, F., Reisenhofer, B., Re, F., Rigo, F., Trambaiolo, P., Amor, M., Lowenstein, J., Merlo, P. M., Daros, C. B., De Castro E Silva Pretto, J. L., Miglioranza, M. H., Torres, M. A. R., De Azevedo Bellagamba, C. C., Chaves, D. Q., Simova, I., Varga, A., Celutkiene, J., Kasprzak, J. D., Wierzbowska-Drabik, K., Lipiec, P., Weiner-Mik, P., Szymczyk, E., Wdowiak-Okrojek, K., Djordjevic-Dikic, A., Dekleva, M., Stankovic, I., Neskovic, A. N., Zagatina, A., Di Salvo, G., Perez, J. E., Camarozano, A. C., Corciu, A. I., Boshchenko, A., Lattanzi, F., Cotrim, C., Fazendas, P., Haberka, M., Sobkowic, B., Kosmala, W., Witkowski, T., Gosciniak, P., Salustri, A., Rodriguez-Zanella, H., Leal, L. I. M., Nikolic, A., Gligorova, S., Urluescu, M. -L., Fiorino, M., Novo, G., Preradovic-Kovacevic, T., Ostojic, M., Beleslin, B., Villari, B., De Nes, M., Paterni, M., Carpeggiani, C., Andreassi, M. G., Scali, Maria Chiara, Ciampi, Quirino, Picano, Eugenio, Bossone, Eduardo, Ferrara, Francesco, Citro, Rodolfo, Colonna, Paolo, Costantino, Marco Fabio, Cortigiani, Lauro, Andrea, Antonello D'., Severino, Sergio, Dodi, Claudio, Gaibazzi, Nicola, Galderisi, Maurizio, Barbieri, Andrea, Monte, Ine, Mori, Fabio, Reisenhofer, Barbara, Re, Federica, Rigo, Fausto, Trambaiolo, Paolo, Amor, Miguel, Lowenstein, Jorge, Merlo, Pablo Martin, Daros, Clarissa Borguezan, De Castro E Silva Pretto, José Lui, Miglioranza, Marcelo Haertel, Torres, Marco A. R., De Azevedo Bellagamba, Clarissa Carmona, Chaves, Daniel Quesada, Simova, Iana, Varga, Albert, Čelutkiene, Jelena, Kasprzak, Jaroslaw D., Wierzbowska-Drabik, Karina, Lipiec, Piotr, Weiner-Mik, Paulina, Szymczyk, Eva, Wdowiak-Okrojek, Katarzyna, Djordjevic-Dikic, Ana, Dekleva, Milica, Stankovic, Ivan, Neskovic, Aleksandar N., Zagatina, Angela, Di Salvo, Giovanni, Perez, Julio E., Camarozano, Ana Cristina, Corciu, Anca Irina, Boshchenko, Alla, Lattanzi, Fabio, Cotrim, Carlo, Fazendas, Paula, Haberka, Maciej, Sobkowic, Bozena, Kosmala, Wojciech, Witkowski, Tomasz, Gosciniak, Piotr, Salustri, Alessandro, Rodriguez-Zanella, Hugo, Leal, Luis Ignacio Martin, Nikolic, Alexandra, Gligorova, Suzana, Urluescu, Madalina-Loredana, Fiorino, Maria, Novo, Giuseppina, Preradovic-Kovacevic, Tamara, Ostojic, Miodrag, Beleslin, Branko, Villari, Bruno, De Nes, Michele, Paterni, Marco, Carpeggiani, Clara, Andreassi, Maria Grazia, Scali, Mc, Ciampi, Q, Picano, E, Bossone, E, Ferrara, F, Citro, R, Colonna, P, Costantino, Mf, Cortigiani, L, D'Andrea, A, Severino, S, Dodi, C, Gaibazzi, N, Galderisi, M, Barbieri, A, Monte, I, Mori, F, Reisenhofer, B, Re, F, Rigo, F, Trambaiolo, P, Amor, M, Lowenstein, J, Merlo, Pm, Daros, Cb, Pretto, Jlde, Miglioranza, Mh, Torres, Mar, Bellagamba, Ccd, Chaves, Dq, Simova, I, Varga, A, Celutkiene, J, Kasprzak, Jd, Wierzbowska-Drabik, K, Lipiec, P, Weiner-Mik, P, Szymczyk, E, Wdowiak-Okrojek, K, Djordjevic-Dikic, A, Dekleva, M, Stankovic, I, Neskovic, An, Zagatina, A, Di Salvo, G, Perez, Je, Camarozano, Ac, Corciu, Ai, Boshchenko, A, Lattanzi, F, Cotrim, C, Fazendas, P, Haberka, M, Sobkowic, B, Kosmala, W, Witkowski, T, Gosciniak, P, Salustri, A, Rodriguez-Zanella, H, Leal, Lim, Nikolic, A, Gligorova, S, Urluescu, Ml, Fiorino, M, Novo, G, Preradovic-Kovacevic, T, Ostojic, M, Beleslin, B, Villari, B, De Nes, M, Paterni, M, and Carpeggiani, C

Subjects
Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Diagnostic accuracy, 030204 cardiovascular system & hematology, 0302 clinical medicine, Nuclear Medicine and Imaging, Reading (process), Medicine, Lung, media_common, Controle de qualidade, certification, lung comets, quality control, stress echocardiography, wall motion, General Medicine, Middle Aged, Echocardiography, Female, Radiology, Cardiology and Cardiovascular Medicine, Human, Echocardiography, Stress, Quality Control, Certification, Lung comets, Quality control, Stress echocardiography, Wall motion, Humans, Internet, Pulmonary Edema, Radiology, Nuclear Medicine and Imaging, medicine.medical_specialty, Correlation coefficient, media_common.quotation_subject, Stress, Lung comet, Ecocardiografia sob estresse, 03 medical and health sciences, Echocardiography, Stre, Internal medicine, Radiology, Nuclear Medicine and imaging, Quality (business), Doenças cardiovasculares, business.industry, 030208 emergency & critical care medicine, Gold standard (test), Lung ultrasound, lcsh:RC666-701, Stress Echo, Nuclear medicine, business, Certificação
Abstract

Background The effectiveness trial “Stress echo (SE) 2020” evaluates novel applications of SE in and beyond coronary artery disease. The core protocol also includes 4-site simplified scan of B-lines by lung ultrasound, useful to assess pulmonary congestion. Purpose To provide web-based upstream quality control and harmonization of B-lines reading criteria. Methods 60 readers (all previously accredited for regional wall motion, 53 B-lines naive) from 52 centers of 16 countries of SE 2020 network read a set of 20 lung ultrasound video-clips selected by the Pisa lab serving as reference standard, after taking an obligatory web-based learning 2-h module ( http://se2020.altervista.org ). Each test clip was scored for B-lines from 0 (black lung, A-lines, no B-lines) to 10 (white lung, coalescing B-lines). The diagnostic gold standard was the concordant assessment of two experienced readers of the Pisa lab. The answer of the reader was considered correct if concordant with reference standard reading ±1 (for instance, reference standard reading of 5 B-lines; correct answer 4, 5, or 6). The a priori determined pass threshold was 18/20 (≥ 90%) with R value (intra-class correlation coefficient) between reference standard and recruiting center) > 0.90. Inter-observer agreement was assessed with intra-class correlation coefficient statistics. Results All 60 readers were successfully accredited: 26 (43%) on first, 24 (40%) on second, and 10 (17%) on third attempt. The average diagnostic accuracy of the 60 accredited readers was 95%, with R value of 0.95 compared to reference standard reading. The 53 B-lines naive scored similarly to the 7 B-lines expert on first attempt (90 versus 95%, p = NS). Compared to the step-1 of quality control for regional wall motion abnormalities, the mean reading time per attempt was shorter (17 ± 3 vs 29 ± 12 min, p

Published
2018
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25. The Tropical Upper Troposphere and Lower Stratosphere in the GEOS-2 GCM

Author

Pawson, S, Takacs, L, Molod, A, Nebuda, S, Chen, M, Rood, R, Read, W. L, and Fiorino, M

Subjects
Geophysics
Abstract

The structure of the tropical upper troposphere and lower stratosphere in the GEOS-2 General Circulation Model (GCM) is discussed. The emphasis of this study is on the reality of monthly-mean temperature and water vapor distributions in the model, compared to reasonable observational estimates. It is shown that although the zonal-mean temperature is in good agreement with observations, the GCM supports an excessive zonal asymmetry near the tropopause compared to the ECMWF Reanalyses. In reality there is a QBO-related variability in the zonally averaged lower stratospheric temperature which is not captured by the model. The observed upper tropospheric temperature and humidity fields show variations related to those in the sea surface temperature, which are not incorporated in the GCM; nevertheless, there is some interannual variability in the GCM, indicating a component arising from internal processes. The model is too moist in the middle troposphere (500 hPa) but too dry in the upper troposphere, suggesting that there is too little vertical transport or too much drying in the GCM. Transport into the stratosphere shows a pronounced annual cycle, with drier air entering the tropical stratosphere when the tropopause is coldest in northern winter; while the alternating dry and moist air masses can be traced ascending through the tropical lower stratosphere, the progression of the anomalies is too rapid.

Published
1999

28. Incidence of Malignancies in HIV‐Infected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

Author

Prosperi M.C., Cozzi Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., BORDERI, MARCO, VERUCCHI, GABRIELLA, PIERGENTILI, BENEDETTA, Prosperi MC., Cozzi-Lepri A., Castagna A., Mussini C., Murri R., Giacometti A., Torti C., Costantini A., Narciso P., Ghinelli F., Antinori A., d'Arminio Monforte A., Moroni M, Carosi G, Galli M, Iardino R, Ippolito G, Lazzarin A, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Ceccherini-Silberstein F, De Luca A, Gervasoni C, Girardi E, Lo Caputo S, Puoti M, Fanti I, Formenti T, Montroni M, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Maggiolo F, Borderi M, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino D, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Pagano G, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotti R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Cauda R, Andreoni M, Antonucci G, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Miccoli A, Carletti F, Mura MS, Madeddu G, Caramello P, Di Perri G, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., Prosperi, M. C. F., Cozzi lepri, A., Castagna, Antonella, Mussini, C., Murri, R., Giacometti, A., Torti, C., Costantini, A., Narciso, P., Ghinelli, F., Antinori, A., and D'arminio Monforte, A.

Subjects
Adult, Male, Microbiology (medical), tumor, medicine.medical_specialty, Prognosi, Prognosis, male, cohort studies, CD4 lymphocyte count, HIV infections, female, neoplasms, Italy, incidence, adult, humans, HIV Infections, Cohort Studies, MALIGNANCIES, HIV, AIDS, CD4, Neoplasms, Immunopathology, Internal medicine, Epidemiology, medicine, Humans, HIV Infection, Sida, biology, business.industry, Incidence, Incidence (epidemiology), Settore MED/07 - Microbiologia e Microbiologia Clinica, biology.organism_classification, Confidence interval, CD4 Lymphocyte Count, Surgery, Infectious Diseases, Cohort, Neoplasm, Female, Viral disease, Cohort Studie, business, Human, Cohort study
Abstract

The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and nonADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3-5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM. © 2010 by the Infectious Diseases Society of America. All rights reserved.

Published
2010
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29. A synoptic-scale overview of the TOGA COARE intensive observing period November 1992 to February 1993 based on analyses from US operational global data assimilation systems

Author

Fiorino, M, Lord, S. J, Lau, W. K.-M, Phoebus, P. A, and Strey, C. G

Subjects
Meteorology And Climatology
Abstract

The operational global analyses from the two major U.S. numerical weather prediction centers, the Navy's Fleet Numerical Oceanography Center and the National Meteorological Center, are used to describe the synoptic-scale features of the 1 Nov. 1992 to 28 Feb. 1993 TOGA COARE intensive observing period (IOP). TOGA COARE is an international field experiment in which a large number of research scientists from the Goddard Laboratory for Atmospheres (Code 910) and the Laboratory for Hydrospheres (Code 970) participated. Two high-amplitude intraseasonal (30-60 day) oscillations passed through the TOGA COARE observational network located in the equatorial western Pacific. Associated with the oscillations were two 6-10 day periods of persistent westerly surface winds at the equator or 'westerly wind bursts.' These events are depicted through time series and time-longitude cross sections of divergence/velocity potential, surface winds, precipitation, ocean mixed-layer depth, and sea surface temperature. The high and low frequency components of the flow in which the intraseasonal oscillations were embedded are shown using seasonal, monthly, and 5-day averages of the surface, 850 and 200 mb winds, precipitation, and sea-level pressure, and a time-longitude cross section of tropical cyclone activity. Independent verification of precipitation comes from near real-time satellite estimates, and a reference climatology is given based on 9 years of ECMWF analyses. Daily 00 UTC analyses of surface winds and sea-level pressure for the entire western Pacific and Indian Ocean are provided to trace the evolution of individual synoptic events.

Published
1993

35. OC-025 Roc-king onwards: iel counts, distributions, & roles in mucosal interpretation

Author

Rostami, K, primary, Marsh, MN, additional, Johnson, MW, additional, Srivastava, A, additional, Ensari, A, additional, Holmes, G, additional, Mohaghegh, H, additional, Neefjes-Borst, A, additional, Bozzola, A, additional, Mathews, S, additional, Mulder, CJ, additional, Mandolesi, A, additional, Ferrero, S, additional, Bancel, B, additional, Volta, U, additional, Rostami-Nejad, M, additional, Ali, JI, additional, Ciacci, C, additional, Sotoudeh, M, additional, Goldin, R, additional, Ganji, A, additional, Robert, M, additional, Bassoti, G, additional, Ghafarzadehgan, K, additional, Carroccio, A, additional, Villanacci, V, additional, Catassi, C, additional, Ciobanu, A, additional, Aldulaimi, D, additional, Fiorentino, M, additional, Derakhshan, M, additional, Becheanu, G, additional, Bateman, A, additional, Zali, MR, additional, Russo, I, additional, Fiorino, M, additional, Maxim, R, additional, Danciu, M, additional, Ishaq, S, additional, Elli, L, additional, Going, J, additional, and Heal, C, additional

Published
2017
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36. Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998-2008

Author

Prosperi, Mc1, Cozzi Lepri, A, Antinori, A, Cassola, G, Torti, C, Ursitti, Ma, Pellizzer, Gp, Giacometti, A, d'Arminio Monforte, A, De Luca, A, Collaborators Moroni M, Icona Foundation Study G. r. o. u. p., Carosi, G, Cauda, R, Di Perri, G, Galli, M, Ghinelli, F, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, Gervasoni, C, Girardi, E, Lo Caputo, S, Maggiolo, F, Murri, R, Mussini, C, Puoti, M, Fanti, I, Formenti, T, Prosperi, Cf, Montroni, M, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Pierri, A, Suter, F, Borderi, M, Verucchi, G, Piergentili, B, Cristini, G, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Carnevale, G, Lorenzotti, S, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Soscia, F, Tacconi, L, Orani, A, Rossotto, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Fiorino, M, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Belfiori, B, Magnani, G, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Narciso, P, Tozzi, V, Vullo, Vincenzo, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Calbi, M, Gallo, L, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D., Prosperi, M. C. F., Cozzi lepri, A., Antinori, A., Cassola, G., Torti, C., Ursitti, M. A., Pellizzer, G. P., Giacometti, A., D'arminio Monforte, A., De Luca, A, Icona Foundation Study, Group, Castagna, Antonella, Prosperi MC, Cozzi-Lepri A, Antinori A, Cassola G, Torti C, Ursitti MA, Pellizzer GP, Giacometti A, d'Arminio Monforte A, De Luca A, Icona, Moroni M, Carosi G, Cauda R, Di Perri G, Galli M, Ghinelli F, Iardino R, Ippolito G, Lazzarin A, Mazzotta F, Panebianco R, Pastore G, Perno CF, Ammassari A, Arici C, Balotta C, Bonfanti P, Capobianchi MR, Castagna A, Ceccherini-Silberstein F, Gervasoni C, Girardi E, Lo Caputo S, Maggiolo F, Murri R, Mussini C, Puoti M, Fanti I, Formenti T, Prosperi CF, Montroni M, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Pierri A, Suter F, Borderi M, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Pozzi M, Pagano G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Soscia F, Tacconi L, Orani A, Rossotto R, Tommasi D, Congedo P, Chiodera A, Castelli P, Rizzardini G, Schlacht I, Ridolfo AL, Foschi A, Salpietro S, Merli S, Melzi S, Moioli MC, Cicconi P, Esposito R, Gori A, Fiorino M, Abrescia N, Chirianni A, Izzo CM, De Marco M, Viglietti R, Manzillo E, Ferrari C, Pizzaferri P, Baldelli F, Belfiori B, Magnani G, Arlotti M, Ortolani P, Andreoni M, Antonucci G, Narciso P, Tozzi V, Vullo V, Zaccarelli M, Acinapura R, De Longis P, Trotta MP, Calbi M, Gallo L, Carletti F, Mura MS, Madeddu G, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D., Prosperi, M, Cozzi Lepri, A, Antinori, A, Cassola, G, Torti, C, Ursitti, M, Pellizzer, G, Giacometti, A, D'Arminio Monforte, A, and Gori, A

Subjects
Adult, Male, HAART, Sexual Behavior, HIV Infections, Infectious Disease, HUMAN-IMMUNODEFICIENCY-VIRUS, Settore MED/17 - MALATTIE INFETTIVE, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Virological response rate, immunological response rates, Poisson regression, Antiretroviral Therapy, Highly Active, Prevalence, Humans, HIV Infection, Pharmacology (medical), Poisson Distribution, Health Policy, HIV, HEPATITIS C VIRUS, HIV–infected patients, Viral Load, CD4 Lymphocyte Count, Treatment Outcome, Italy, HIV-1, Female, Immunological response rate, Human
Abstract

Background: This study provides an estimate of the proportion of HIV-positive patients in Italian clinics showing an 'adverse prognosis' (defined as a CD4 count ≤200cells/μL or an HIV RNA >50 HIV-1 RNA copies/mL) over time, and investigates whether this proportion varied according to patients' characteristics. Methods: We estimated the annual proportion of patients with a CD4 count ≤200cells/μL or HIV RNA >50copies/mL out of the total number of patients in the Icona Foundation cohort seen in any given year, both overall and after stratifying by demographical and treatment status groups. Generalized estimating equation models for Poisson regression were applied. Results: In 1998-2008, the prevalence of patients with a CD4 count ≤200cells/μL decreased from 14 to 6% [adjusted relative risk (RR) 0.86/year; 95% confidence interval (CI) 0.84-0.88; P50copies/mL decreased from 66 to 40% (adjusted RR 0.95/year; 95% CI 0.95-0.96; P

Published
2011

37. Factors Influencing Depression Endpoints Research (FINDER): baseline results of Italian patients with depression

Author

Grassi, L, Rossi, A, Barraco, A, Italian Finder Group, Aguglia, E, Ambrosio, LA, Rossi, NB, Bellomo, A, Belloni, G, Biza, M, Bucci, N, Cappuccio, R, Carboni, MG, Cesari, G, Ciappi, F, Cipriani, AM, Cordioli, L, Delcuratolo, V, Di Cello, A, Di Fiorino, M, Di Lauro, A, Falabella, V, Falavolti, S, Farina, G, Federico, T, Gabrielli, F, Gazzera, G, Mariani, G, Minnai, G, Nano, D, Nicolo, G, Parnetti, L, Pierri, G, Puoti, M, Riccio, A, Romeo, A, Veneto, V, Lugo, I, Prodi, PR, Serrano, M, Sorbi, S, Toniolo, E, Venanzini, R, Vender, S, Venuta, M, Volpe, M., FERRARESE, CARLO, Grassi, L, Rossi, A, Barraco, A, Italian Finder, G, Aguglia, E, Ambrosio, L, Rossi, N, Bellomo, A, Belloni, G, Biza, M, Bucci, N, Cappuccio, R, Carboni, M, Cesari, G, Ciappi, F, Cipriani, A, Cordioli, L, Delcuratolo, V, Di Cello, A, Di Fiorino, M, Di Lauro, A, Falabella, V, Falavolti, S, Farina, G, Federico, T, Ferrarese, C, Gabrielli, F, Gazzera, G, Mariani, G, Minnai, G, Nano, D, Nicolo, G, Parnetti, L, Pierri, G, Puoti, M, Riccio, A, Romeo, A, Veneto, V, Lugo, I, Prodi, P, Serrano, M, Sorbi, S, Toniolo, E, Venanzini, R, Vender, S, Venuta, M, and Volpe, M

Subjects
Sertraline, medicine.medical_specialty, education.field_of_study, Visual analogue scale, business.industry, lcsh:RC435-571, Population, Depression Outcome, Depression, HRQoL, Hospital Anxiety and Depression Scale, Psychiatry and Mental health, Psychiatric history, lcsh:Psychiatry, depression, medicine, Escitalopram, Anxiety, medicine.symptom, Primary Research, business, Psychiatry, education, Depression (differential diagnoses), medicine.drug
Abstract

Background Factors Influencing Depression Endpoints Research (FINDER) is a 6-month, prospective, observational study carried out in 12 European countries aimed at investigating health-related quality of life (HRQoL) in outpatients receiving pharmacological treatment for a first or new depressive episode. Baseline characteristics of patients enrolled in Italy are presented. Methods All treatment decisions were at the discretion of the investigator. Data were collected at baseline and after 3 and 6 months of treatment. Baseline evaluations included demographics, medical and psychiatric history, and medications used in the last 24 months and prescribed at enrolment. The Hospital Anxiety and Depression Scale (HADS), was adopted to evaluate depressive symptoms, while somatic and painful physical symptoms were assessed by using the Somatic Symptom Inventory (SSI) and a 0 to 100 mm visual analogue scale (VAS), HRQoL via 36-item Short Form Health Survey (SF-36), and the European Quality of Life 5-Dimensions (EQ-5D) instrument. Results A total of 513 patients were recruited across 38 sites. The mean ± standard deviation (SD) age at first depressive episode was 38.7 ± 15.9 years, the mean duration of depression 10.6 ± 12.3 years. The most common psychiatric comorbidities in the previous 24 months were anxiety/panic (72.6%) and obsessive/compulsive disorders (13.4%), while 35.9% had functional somatic syndromes. Most patients (65.1%) reported pain from any cause. Monotherapy with selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) was prescribed at enrolment in 64.5% and 6.4% of the cases, respectively. The most commonly prescribed agents were sertraline (17.3%), escitalopram (16.2%), venlaflaxine (15.6%) and paroxetine (14.8%). The mean HADS subscores for depression and anxiety were 13.3 ± 4.2 and 12.2 ± 3.9, respectively; 76.4% of patients could be defined as being 'probable cases' for depression and 66.2% for anxiety. The mean total score of VAS-pain in the last week was 42.9 ± 27.1, with highest scores reported in the 'interference of pain with daily activities' and in 'amount of time patient was awake and had pain'. From SF-36, the worst health status was found for role limitations due to emotional problem, mental health and social functioning. A mean score < 50 (that is, below the standardised population norm) was also found in all remaining domains. The SF-36 summary scores and EQ-5D (health status and VAS) were lower in patients with moderate/severe pain than in those with no or mild pain. Conclusion The baseline results of patients enrolled in the FINDER study in Italy show clinical and functional impairments, and poor HRQoL. The results obtained after 6 months of therapy will permit better understanding the effects of different variables on clinical outcomes and HRQoL.

Published
2009

38. Paroxetine and fluoxetine effects on mood and cognitive functions in depressed nondemented elderly patients

Author

Cassano G, B, Puca F, Scapicchio P, L, Trabucchi M, Aguglia E, Albano C, Bruzzone G, Antico L, Guidi L, Tricerfi A, Cappa C, Smerieri G, Simonini E, Tilli C, Caserta F, Varia S, Cerqua R, Califano M, Cerqua G, Chioma V, Bertuzzi D, Menetti M, Corsonello F, Zottola C, Pranno L, De Candia R, Di Fiorino M, Cerfi A, Bani A, Fichera G, Bonomol G, Giberti G, Cassis S, Grumelli B, Galetti G, Anni G, Guala A, Lancia U, Saponaro A, Longobardi L, Bruni A, Macchione C, Fantò F, Baietto T, Martucci M, Faronl J, Calandriello L, Meduri M, Di Rosa A, E, Cacciola M, Mordechai M, Zuccaro S, M, Palummeri E, Cella A, Trasciatti S, Paolucci S, Coiro R, Pedone V, Angelini A, Piani F, Righini D, Puca E, Brancasi B, Rengo F, Cacciatore F, Robotti C, A, Bilone F, Nicotra M, C, Rotolo V, Salsi A, De Carolis S, Scarpino O, Del Gobbo M, Sdanganelli F, Di Biase A, Pontrelli B, Spilimbergo P, G, Di Costanzo E, Matranga M, Stocchi E, Grassini P, Valenti G, Fontana V, Venuta M, Guaraldi G, P, Zanni L, Verrienti P, Stoppelli N, Scardino V, Vischia F, Pirfo E., ABETE, PASQUALE, Cassano, G, B, Puca, F, Scapicchio, P, L, Trabucchi, M, Aguglia, E, Albano, C, Bruzzone, G, Antico, L, Guidi, L, Tricerfi, A, Cappa, C, Smerieri, G, Simonini, E, Tilli, C, Caserta, F, Varia, S, Cerqua, R, Califano, M, Cerqua, G, Chioma, V, Bertuzzi, D, Menetti, M, Corsonello, F, Zottola, C, Pranno, L, De Candia, R, Di Fiorino, M, Cerfi, A, Bani, A, Fichera, G, Bonomol, G, Giberti, G, Cassis, S, Grumelli, B, Galetti, G, Anni, G, Guala, A, Lancia, U, Saponaro, A, Longobardi, L, Bruni, A, Macchione, C, Fantò, F, Baietto, T, Martucci, M, Faronl, J, Calandriello, L, Meduri, M, Di Rosa, A, E, Cacciola, M, Mordechai, M, Zuccaro, S, M, Palummeri, E, Cella, A, Trasciatti, S, Paolucci, S, Coiro, R, Pedone, V, Angelini, A, Piani, F, Righini, D, Puca, E, Brancasi, B, Rengo, F, Abete, Pasquale, Cacciatore, F, Robotti, C, A, Bilone, F, Nicotra, M, Rotolo, V, Salsi, A, De Carolis, S, Scarpino, O, Del Gobbo, M, Sdanganelli, F, Di Biase, A, Pontrelli, B, Spilimbergo, P, G, Di Costanzo, E, Matranga, M, Stocchi, E, Grassini, P, Valenti, G, Fontana, V, Venuta, M, Guaraldi, G, P, Zanni, L, Verrienti, P, Stoppelli, N, Scardino, V, Vischia, F, and Pirfo, E.

Published
2002

39. Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study

Author

Prosperi, Mc, Cozzi Lepri, A, Castagna, A, Mussini, C, Murri, R, Giacometti, A, Torti, Carlo, Costantini, A, Narciso, P, Ghinelli, F, Antinori, A, d'Arminio Monforte, A, Icona Foundation Study Group, Moroni, M, Carosi, Giampiero, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Maggiolo, F, Puoti, Massimo, Torti, C, Fanti, I, Formenti, T, Montroni, M, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Pierri, A, Suter, F, Borderi, M, Verucchi, G, Piergentili, B, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, D, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Carnevale, G, Lorenzotti, S, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Soscia, F, Tacconi, L, Orani, A, Rossotti, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Fiorino, M, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Belfiori, B, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Calbi, M, Gallo, L, Miccoli, A, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.

Published
2010

40. Monoclonal anti-melanoma antibodies IKH-1 and IKH-2 which work on formalin-fixed, paraffin embedded tissues: Characterization, clinical trials and comparative studies with HMB-45

Author

Janet Richards, Fiorino M. DiGregorio, Masahiko Ishihara, Teresa Pietruk, Richard J. Zarbo, Ken Hashimoto, and Mitsuru Setoyama

Subjects
Pathology, medicine.medical_specialty, Tissue Fixation, medicine.drug_class, Immunoelectron microscopy, Melanoma, Experimental, Dermatology, Biology, Monoclonal antibody, Biochemistry, Mice, Antigen, Antigens, Neoplasm, Formaldehyde, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Animals, Humans, Microscopy, Immunoelectron, Melanoma, Molecular Biology, Clinical Trials as Topic, Hybridomas, Antibodies, Monoclonal, medicine.disease, Immunohistochemistry, Molecular biology, HMB-45, Cell Transformation, Neoplastic, Paraffin, Monoclonal, biology.protein, Tetradecanoylphorbol Acetate, Antibody
Abstract

Mouse monoclonal antibodies (MoAbs), IKH-1 and IKH-2, were produced against cloned human melanoma cells, KHm-6, which were cultured with 12-O-tetradecanoylphorbol-13-acetate (TPA) and processed by formalin fixation and alcohol dehydration (FFAD). According to the biochemical analysis, antigenic substances which reacted with IKH-1 were 34.0-60.0 kDa glycoproteins, and those which reacted with IKH-2 were 33.5, 34.5 and 36.0 kDa glycoproteins. Immunoelectron microscopy revealed that reaction products of IKH-1 were seen in some membranous vesicles, premelanosomes and cell membrane of TPA-treated KHm-6 cells, while IKH-2 recognized only premelanosomal structures. Immunohistochemical tests revealed that IKH-1 and IKH-2 have a high sensitivity (94.0% and 85.0%, respectively) to formalin-fixed, paraffin-embedded (FFPE) tissue sections of malignant melanomas. IKH-1 had a high specificity and IKH-2 and 100% specificity to FFPE tissue sections of melanocytic lesions.

Published
1992
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49. Identification of Anthropogenic Climate Change using a Second-Generation Reanalysis

Author

Santer, B.D., Wigley, T.M.L., Simmons, A.J., Kållberg, P., Kelly, G.A., Uppala, S., Ammann, C., Boyle, J.S., Brüggemann, W., Doutriaux, C., Fiorino, M., Mears, C., Meehl, G.A., Sausen, R., Taylor, K.E., Washington, W.M., Wehner, M.F., and Wentz, F.J.

Subjects
climate change, tropopause, attribution of detection of climate change
Published
2004

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