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13 results on '"Fiorini, Chiara"'

1. SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response

Author

Alberici, Federico, Affatato, Stefania, Moratto, Daniele, Mescia, Federica, Delbarba, Elisa, Guerini, Alice, Tedesco, Martina, Burbelo, Peter D., Zani, Roberta, Castagna, Ilaria, Gallico, Agnese, Tonoli, Mattia, Venturini, Margherita, Roccaro, Aldo M., Giacomelli, Mauro, Cohen, Jeffrey I., Giustini, Viviana, Dobbs, Kerry, Su, Helen C., Fiorini, Chiara, Quaresima, Virginia, Viola, Fabio Battista, Vizzardi, Valerio, Gaggiotti, Mario, Bossini, Nicola, Gaggia, Paola, Badolato, Raffaele, Notarangelo, Luigi D., Chiarini, Marco, and Scolari, Francesco

Published
2022
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5. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

Author

Carmona-Rivera, Carmelo, primary, Zhang, Yu, additional, Dobbs, Kerry, additional, Markowitz, Tovah E., additional, Dalgard, Clifton L., additional, Oler, Andrew J., additional, Claybaugh, Dillon R., additional, Draper, Deborah, additional, Truong, Meng, additional, Delmonte, Ottavia M., additional, Licciardi, Francesco, additional, Ramenghi, Ugo, additional, Crescenzio, Nicoletta, additional, Imberti, Luisa, additional, Sottini, Alessandra, additional, Quaresima, Virginia, additional, Fiorini, Chiara, additional, Discepolo, Valentina, additional, Lo Vecchio, Andrea, additional, Guarino, Alfredo, additional, Pierri, Luca, additional, Catzola, Andrea, additional, Biondi, Andrea, additional, Bonfanti, Paolo, additional, Poli Harlowe, Maria C., additional, Espinosa, Yasmin, additional, Astudillo, Camila, additional, Rey-Jurado, Emma, additional, Vial, Cecilia, additional, de la Cruz, Javiera, additional, Gonzalez, Ricardo, additional, Pinera, Cecilia, additional, Mays, Jacqueline W., additional, Ng, Ashley, additional, Platt, Andrew, additional, Drolet, Beth, additional, Moon, John, additional, Cowen, Edward W., additional, Kenney, Heather, additional, Weber, Sarah E., additional, Castagnoli, Riccardo, additional, Magliocco, Mary, additional, Stack, Michael A., additional, Montealegre, Gina, additional, Barron, Karyl, additional, Fink, Danielle L., additional, Kuhns, Douglas B., additional, Hewitt, Stephen M., additional, Arkin, Lisa M., additional, Chertow, Daniel S., additional, Su, Helen C., additional, Notarangelo, Luigi D., additional, and Kaplan, Mariana J., additional

Published
2022
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6. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

Author

Carmona-Rivera, C, Zhang, Y, Dobbs, K, Markowitz, T, Dalgard, C, Oler, A, Claybaugh, D, Draper, D, Truong, M, Delmonte, O, Licciardi, F, Ramenghi, U, Crescenzio, N, Imberti, L, Sottini, A, Quaresima, V, Fiorini, C, Discepolo, V, Lo Vecchio, A, Guarino, A, Pierri, L, Catzola, A, Biondi, A, Bonfanti, P, Poli Harlowe, M, Espinosa, Y, Astudillo, C, Rey-Jurado, E, Vial, C, De la Cruz, J, Gonzalez, R, Pinera, C, Mays, J, Ng, A, Platt, A, Drolet, B, Moon, J, Cowen, E, Kenney, H, Weber, S, Castagnoli, R, Magliocco, M, Stack, M, Montealegre Sanchez, G, Barron, K, Fink, D, Kuhns, D, Hewitt, S, Arkin, L, Chertow, D, Su, H, Notarangelo, L, Kaplan, M, Carmona-Rivera, Carmelo, Zhang, Yu, Dobbs, Kerry, Markowitz, Tovah E, Dalgard, Clifton L, Oler, Andrew J, Claybaugh, Dillon R, Draper, Deborah, Truong, Meng, Delmonte, Ottavia M, Licciardi, Francesco, Ramenghi, Ugo, Crescenzio, Nicoletta, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Fiorini, Chiara, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Pierri, Luca, Catzola, Andrea, Biondi, Andrea, Bonfanti, Paolo, Poli Harlowe, Maria Cecilia, Espinosa, Yazmin, Astudillo, Camila A, Rey-Jurado, Emma, Vial, Cecilia, De la Cruz, Javiera, Gonzalez, Ricardo, Pinera, Cecilia, Mays, Jacqueline W, Ng, Ashley, Platt, Andrew, Drolet, Beth A, Moon, John, Cowen, Edward W, Kenney, Heather, Weber, Sarah E, Castagnoli, Riccardo, Magliocco, Mary K, Stack, Michael Austin, Montealegre Sanchez, Gina A, Barron, Karyl, Fink, Danielle L, Kuhns, Douglas B, Hewitt, Stephen M, Arkin, Lisa M, Chertow, Daniel S, Su, Helen C, Notarangelo, Luigi D, Kaplan, Mariana J, Carmona-Rivera, C, Zhang, Y, Dobbs, K, Markowitz, T, Dalgard, C, Oler, A, Claybaugh, D, Draper, D, Truong, M, Delmonte, O, Licciardi, F, Ramenghi, U, Crescenzio, N, Imberti, L, Sottini, A, Quaresima, V, Fiorini, C, Discepolo, V, Lo Vecchio, A, Guarino, A, Pierri, L, Catzola, A, Biondi, A, Bonfanti, P, Poli Harlowe, M, Espinosa, Y, Astudillo, C, Rey-Jurado, E, Vial, C, De la Cruz, J, Gonzalez, R, Pinera, C, Mays, J, Ng, A, Platt, A, Drolet, B, Moon, J, Cowen, E, Kenney, H, Weber, S, Castagnoli, R, Magliocco, M, Stack, M, Montealegre Sanchez, G, Barron, K, Fink, D, Kuhns, D, Hewitt, S, Arkin, L, Chertow, D, Su, H, Notarangelo, L, Kaplan, M, Carmona-Rivera, Carmelo, Zhang, Yu, Dobbs, Kerry, Markowitz, Tovah E, Dalgard, Clifton L, Oler, Andrew J, Claybaugh, Dillon R, Draper, Deborah, Truong, Meng, Delmonte, Ottavia M, Licciardi, Francesco, Ramenghi, Ugo, Crescenzio, Nicoletta, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Fiorini, Chiara, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Pierri, Luca, Catzola, Andrea, Biondi, Andrea, Bonfanti, Paolo, Poli Harlowe, Maria Cecilia, Espinosa, Yazmin, Astudillo, Camila A, Rey-Jurado, Emma, Vial, Cecilia, De la Cruz, Javiera, Gonzalez, Ricardo, Pinera, Cecilia, Mays, Jacqueline W, Ng, Ashley, Platt, Andrew, Drolet, Beth A, Moon, John, Cowen, Edward W, Kenney, Heather, Weber, Sarah E, Castagnoli, Riccardo, Magliocco, Mary K, Stack, Michael Austin, Montealegre Sanchez, Gina A, Barron, Karyl, Fink, Danielle L, Kuhns, Douglas B, Hewitt, Stephen M, Arkin, Lisa M, Chertow, Daniel S, Su, Helen C, Notarangelo, Luigi D, and Kaplan, Mariana J

Abstract

Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease, including multisystem inflammatory syndrome in children (MIS-C) and chilblain-like lesions (CLLs), otherwise known as "COVID toes,"remains unclear. Studying multinational cohorts, we found that, in CLLs, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. MIS-C and CLL serum samples displayed decreased NET degradation ability, in association with C1q and G-actin or anti-NET antibodies, respectively, but not with genetic variants of DNases. In adult COVID-19, persistent elevations in NETs after disease diagnosis were detected but did not occur in asymptomatic infection. COVID-19-affected adults displayed significant prevalence of impaired NET degradation, in association with anti-DNase1L3, G-actin, and specific disease manifestations, but not with genetic variants of DNases. NETs were detected in many organs of adult patients who died from COVID-19 complications. Infection with the Omicron variant was associated with decreased NET levels when compared with other SARS-CoV-2 strains. These data support a role for NETs in the pathogenesis and severity of COVID-19 in pediatric and adult patients.

Published
2022

11. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

Author

Carmelo Carmona-Rivera, Yu Zhang, Kerry Dobbs, Tovah E. Markowitz, Clifton L. Dalgard, Andrew J. Oler, Dillon R. Claybaugh, Deborah Draper, Meng Truong, Ottavia M. Delmonte, Francesco Licciardi, Ugo Ramenghi, Nicoletta Crescenzio, Luisa Imberti, Alessandra Sottini, Virginia Quaresima, Chiara Fiorini, Valentina Discepolo, Andrea Lo Vecchio, Alfredo Guarino, Luca Pierri, Andrea Catzola, Andrea Biondi, Paolo Bonfanti, Maria C. Poli Harlowe, Yasmin Espinosa, Camila Astudillo, Emma Rey-Jurado, Cecilia Vial, Javiera de la Cruz, Ricardo Gonzalez, Cecilia Pinera, Jacqueline W. Mays, Ashley Ng, Andrew Platt, Beth Drolet, John Moon, Edward W. Cowen, Heather Kenney, Sarah E. Weber, Riccardo Castagnoli, Mary Magliocco, Michael A. Stack, Gina Montealegre, Karyl Barron, Danielle L. Fink, Douglas B. Kuhns, Stephen M. Hewitt, Lisa M. Arkin, Daniel S. Chertow, Helen C. Su, Luigi D. Notarangelo, Mariana J. Kaplan, Carmona-Rivera, C, Zhang, Y, Dobbs, K, Markowitz, T, Dalgard, C, Oler, A, Claybaugh, D, Draper, D, Truong, M, Delmonte, O, Licciardi, F, Ramenghi, U, Crescenzio, N, Imberti, L, Sottini, A, Quaresima, V, Fiorini, C, Discepolo, V, Lo Vecchio, A, Guarino, A, Pierri, L, Catzola, A, Biondi, A, Bonfanti, P, Poli Harlowe, M, Espinosa, Y, Astudillo, C, Rey-Jurado, E, Vial, C, De la Cruz, J, Gonzalez, R, Pinera, C, Mays, J, Ng, A, Platt, A, Drolet, B, Moon, J, Cowen, E, Kenney, H, Weber, S, Castagnoli, R, Magliocco, M, Stack, M, Montealegre Sanchez, G, Barron, K, Fink, D, Kuhns, D, Hewitt, S, Arkin, L, Chertow, D, Su, H, Notarangelo, L, Kaplan, M, Carmona-Rivera, Carmelo, Zhang, Yu, Dobbs, Kerry, Markowitz, Tovah E, Dalgard, Clifton L, Oler, Andrew J, Claybaugh, Dillon R, Draper, Deborah, Truong, Meng, Delmonte, Ottavia M, Licciardi, Francesco, Ramenghi, Ugo, Crescenzio, Nicoletta, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Fiorini, Chiara, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Pierri, Luca, Catzola, Andrea, Biondi, Andrea, Bonfanti, Paolo, Poli Harlowe, Maria C, Espinosa, Yasmin, Astudillo, Camila, Rey-Jurado, Emma, Vial, Cecilia, de la Cruz, Javiera, Gonzalez, Ricardo, Pinera, Cecilia, Mays, Jacqueline W, Ng, Ashley, Platt, Andrew, Drolet, Beth, Moon, John, Cowen, Edward W, Kenney, Heather, Weber, Sarah E, Castagnoli, Riccardo, Magliocco, Mary, Stack, Michael A, Montealegre, Gina, Barron, Karyl, Fink, Danielle L, Kuhns, Douglas B, Hewitt, Stephen M, Arkin, Lisa M, Chertow, Daniel S, Su, Helen C, Notarangelo, Luigi D, and Kaplan, Mariana J

Subjects
Adult, Inflammation, Infectious disease, Neutrophils, SARS-CoV-2, Neutrophil, COVID-19, General Medicine, Actins, Child, Deoxyribonuclease I, Humans, Systemic Inflammatory Response Syndrome, Extracellular Traps
Abstract

Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease including MIS-C and chilblain-like lesions (CLL), otherwise known as “COVID toes”, remains unclear. Studying multinational cohorts, we found that, in CLL, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. MIS-C and CLL serum samples displayed decreased NET degradation ability, in association with C1q and G-actin or anti-NET antibodies, respectively, but not with genetic variants of DNases. In adult COVID-19, persistent elevations in NETs post-disease diagnosis were detected but did not occur in asymptomatic infection. COVID-19-affected adults displayed significant prevalence of impaired NET degradation, in association with anti-DNase1L3, G-actin, and specific disease manifestations, but not with genetic variants of DNases. NETs were detected in many organs of adult patients who died from COVID-19 complications. Infection with the Omicron variant was associated with decreased levels of NETs when compared to other SARS-CoV-2 strains. These data support a role for NETs in the pathogenesis and severity of COVID-19 in pediatric and adult patients.SummaryNET formation and degradation are dysregulated in pediatric and symptomatic adult patients with various complications of COVID-19, in association with disease severity. NET degradation impairments are multifactorial and associated with natural inhibitors of DNase 1, G-actin and anti-DNase1L3 and anti-NET antibodies. Infection with the Omicron variant is associated with decreased levels of NETs when compared to other SARS-CoV-2 strains.

Published
2022

12. Abnormal antibodies to self-carbohydrates in SARS-CoV-2-infected patients.

Author

Butler DL, Imberti L, Quaresima V, Fiorini C, and Gildersleeve JC

Abstract

Our immune system is critical for preventing and treating SARS-CoV-2 infections, but aberrant immune responses can have deleterious effects. While antibodies to glycans could recognize the virus and influence the clinical outcome, little is known about their roles. Using a carbohydrate antigen microarray, we profiled serum antibodies in healthy control subjects and COVID-19 patients from two separate cohorts. COVID-19 patients had numerous autoantibodies to self-glycans, including antiganglioside antibodies that can cause neurological disorders. Additionally, nearly all antiglycan IgM signals were lower in COVID-19 patients, indicating a global dysregulation of this class of antibodies. Autoantibodies to certain N -linked glycans correlated with more severe disease, as did low levels of antibodies to the Forssman antigen and ovalbumin. Collectively, this study indicates that expanded testing for antiglycan antibodies could be beneficial for clinical analysis of COVID-19 patients and illustrates the importance of including host and viral carbohydrate antigens when studying immune responses to viruses., (Published by Oxford University Press on behalf of the National Academy of Sciences 2021.)

Published
2022
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13. Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19.

Author

Carmona-Rivera C, Zhang Y, Dobbs K, Markowitz TE, Dalgard CL, Oler AJ, Claybaugh DR, Draper D, Truong M, Delmonte OM, Licciardi F, Ramenghi U, Crescenzio N, Imberti L, Sottini A, Quaresima V, Fiorini C, Discepolo V, Lo Vecchio A, Guarino A, Pierri L, Catzola A, Biondi A, Bonfanti P, Poli Harlowe MC, Espinosa Y, Astudillo C, Rey-Jurado E, Vial C, de la Cruz J, Gonzalez R, Pinera C, Mays JW, Ng A, Platt A, Drolet B, Moon J, Cowen EW, Kenney H, Weber SE, Castagnoli R, Magliocco M, Stack MA, Montealegre G, Barron K, Hewitt SM, Arkin LM, Chertow DS, Su HC, Notarangelo LD, and Kaplan MJ

Abstract

Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease including MIS-C and chilblain-like lesions (CLL), otherwise known as "COVID toes", remains unclear. Studying multinational cohorts, we found that, in CLL, NETs were significantly increased in serum and skin. There was geographic variability in the prevalence of increased NETs in MIS-C, in association with disease severity. MIS-C and CLL serum samples displayed decreased NET degradation ability, in association with C1q and G-actin or anti-NET antibodies, respectively, but not with genetic variants of DNases. In adult COVID-19, persistent elevations in NETs post-disease diagnosis were detected but did not occur in asymptomatic infection. COVID-19-affected adults displayed significant prevalence of impaired NET degradation, in association with anti-DNase1L3, G-actin, and specific disease manifestations, but not with genetic variants of DNases. NETs were detected in many organs of adult patients who died from COVID-19 complications. Infection with the Omicron variant was associated with decreased levels of NETs when compared to other SARS-CoV-2 strains. These data support a role for NETs in the pathogenesis and severity of COVID-19 in pediatric and adult patients., Summary: NET formation and degradation are dysregulated in pediatric and symptomatic adult patients with various complications of COVID-19, in association with disease severity. NET degradation impairments are multifactorial and associated with natural inhibitors of DNase 1, G-actin and anti-DNase1L3 and anti-NET antibodies. Infection with the Omicron variant is associated with decreased levels of NETs when compared to other SARS-CoV-2 strains.

Published
2022
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