1. Pregnancy in Charcot-Marie-Tooth disease: Data from the Italian CMT national registry
- Author
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Chiara Pisciotta 1, Daniela Calabrese 1, Lucio Santoro 2, Irene Tramacere 1, Fiore Manganelli 2, Gian Maria Fabrizi 3, Angelo Schenone, Tiziana Cavallaro 3, Marina Grandis, Stefano C Previtali 4, Isabella Allegri 5, Luca Padua, Costanza Pazzaglia 6, Paola Saveri 1, Aldo Quattrone 7, Paola Valentino 8, Stefano Tozza 2, Luca Gentile 9, Md Massimo Russo 9, Anna Mazzeo 9, Maria Claudia Trapasso 5, Fabio Parazzini 10, Giuseppe Vita 9, Davide Pareyson 1, Italian CMT Network, Pisciotta, C., Calabrese, D., Santoro, L., Tramacere, I., Manganelli, F., Fabrizi, G. M., Schenone, A., Cavallaro, T., Grandis, M., Previtali, S. C., Allegri, I., Padua, L., Pazzaglia, C., Saveri, P., Quattrone, A., Valentino, P., Tozza, S., Gentile, L., Russo, M., Mazzeo, A., Trapasso, M. C., Parazzini, F., Vita, G., and Pareyson, D.
- Subjects
Registrie ,Placenta Previa ,0302 clinical medicine ,Retrospective Studie ,Charcot-Marie-Tooth Disease ,Pregnancy ,Abortion, Spontaneou ,Birth Weight ,Registries ,Obstetric Labor Complication ,education.field_of_study ,030219 obstetrics & reproductive medicine ,postpartum bleeding ,Obstetrics ,disease course ,Pregnancy Outcome ,Gestational age ,Middle Aged ,Symptom Flare Up ,Italy ,Premature birth ,Charcot-Marie-Tooth disease ,Gestation ,Premature Birth ,Female ,Human ,Adult ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Birth weight ,Population ,Gestational Age ,Article ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,delivery complications ,education ,Breech Presentation ,Aged ,Retrospective Studies ,business.industry ,Cesarean Section ,Postpartum Hemorrhage ,Infant, Newborn ,medicine.disease ,Placenta previa ,Obstetric Labor Complications ,nervous system diseases ,Abortion, Spontaneous ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveTo collect information on frequency of pregnancy and delivery complications in Charcot-Marie-Tooth (CMT) disease and on CMT course during pregnancy.MethodsThrough an ad hoc online questionnaire, we investigated pregnancy and neuropathy course in women with CMT adhering to the Italian CMT Registry. Data were compared to those of controls (recruited among friends and unaffected relatives) and the Italian (or other reference) population.ResultsWe collected data on 193 pregnancies from 86 women with CMT (age 20–73 years) with 157 deliveries (81.4%) after a mean of 38.6 gestational weeks. In women with CMT, there were no differences compared to controls (59 pregnancies and 46 deliveries from 24 controls) and the reference population for miscarriages (11.4%) and planned (21.0%) and emergency (14.0%) cesarean sections. We found a significantly higher frequency of placenta previa (1.6% vs 0.4%), abnormal fetal presentations (8.4% vs 4.5%), and preterm deliveries (20.3% vs 6.9%; most in week 34–36 of gestation) compared to reference populations. Excluding twins, newborn weight did not differ from the reference population. Postpartum bleeding rate in patients with CMT (2.1%) was similar to that of the general population (2.4%). CMT status worsened during 18 of 193 pregnancies (9.3%) with no recovery in 16 of them and with similar figures in the CMT1A and non-CMT1A subtypes.ConclusionsWe observed higher rates of placenta previa, abnormal presentations, and preterm deliveries in CMT, but pregnancy outcome and newborn weight and health were similar to those of the reference populations. Worsening of CMT is not infrequent and occurs not only in CMT1A. Pregnant women with CMT should be monitored with particular care.
- Published
- 2020