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1. Isoform differences in substrate recognition by glycogen synthase kinases 3alpha and 3beta in the phosphorylation of phosphatase inhibitor 2

Author

Wang, Q. May, Park, In-Kyung, Fiol, Carol J., Roach, Peter J., and DePaoli-Roach, Anna A.

Subjects
Phosphorylation -- Observations, Enzyme inhibitors -- Analysis, Protein kinases -- Analysis, Biological sciences, Chemistry
Abstract

An analysis of the phosphorylation of inhibitor 2, the regulatory subunit of the ATP-Mg-dependent protein phosphatase, by glycogen synthase kinase 3 (GSK-3), resulting in stimulation of the phosphatase, confirms major differences in substrate recognition by different isoforms of the same protein kinase. Substrate recognition by GSK-3 involves many determinants.

Published
1994

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