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7. Current European AQ Planning at Regional and Local Scale

Author

Belis, C., Baldasano, J., Blond, N., Bouland, C., Buekers, J., Carnevale, C., Cherubini, A., Clappier, A., De Saeger, E., Douros, J., Finzi, G., Fragkou, E., Gama, C., Graff, A., Guariso, G., Janssen, S., Juda-Rezler, K., Karvosenoja, N., Maffeis, G., Martilli, A., Mills, S., Miranda, A. I., Moussiopoulos, N., Nahorski, Z., Pisoni, E., Ponche, J.-L., Rasoloharimahefa, M., Real, E., Reizer, M., Relvas, H., Roncolato, D., Tainio, M., Thunis, P., Viaene, P., Vlachokostas, C., Volta, M., White, L., Kacprzyk, Janusz, Series editor, Guariso, Giorgio, editor, and Volta, Marialuisa, editor

Published
2017
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8. A Framework for Integrated Assessment Modelling

Author

Blond, N., Carnevale, C., Douros, J., Finzi, G., Guariso, G., Janssen, S., Maffeis, G., Martilli, A., Pisoni, E., Real, E., Turrini, E., Viaene, P., Volta, M., Kacprzyk, Janusz, Series editor, Guariso, Giorgio, editor, and Volta, Marialuisa, editor

Published
2017
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20. Current European AQ Planning at Regional and Local Scale

Author

Belis, C., primary, Baldasano, J., additional, Blond, N., additional, Bouland, C., additional, Buekers, J., additional, Carnevale, C., additional, Cherubini, A., additional, Clappier, A., additional, De Saeger, E., additional, Douros, J., additional, Finzi, G., additional, Fragkou, E., additional, Gama, C., additional, Graff, A., additional, Guariso, G., additional, Janssen, S., additional, Juda-Rezler, K., additional, Karvosenoja, N., additional, Maffeis, G., additional, Martilli, A., additional, Mills, S., additional, Miranda, A. I., additional, Moussiopoulos, N., additional, Nahorski, Z., additional, Pisoni, E., additional, Ponche, J.-L., additional, Rasoloharimahefa, M., additional, Real, E., additional, Reizer, M., additional, Relvas, H., additional, Roncolato, D., additional, Tainio, M., additional, Thunis, P., additional, Viaene, P., additional, Vlachokostas, C., additional, Volta, M., additional, and White, L., additional

Published
2016
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21. A Framework for Integrated Assessment Modelling

Author

Blond, N., primary, Carnevale, C., additional, Douros, J., additional, Finzi, G., additional, Guariso, G., additional, Janssen, S., additional, Maffeis, G., additional, Martilli, A., additional, Pisoni, E., additional, Real, E., additional, Turrini, E., additional, Viaene, P., additional, and Volta, M., additional

Published
2016
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30. The INFN-Grid Testbed

Author

Alfieri, R., Barbera, R., Belluomo, P., Cavalli, A., Cecchini, R., Chierici, A., Ciaschini, V., Dell’Agnello, L., Donno, F., Ferro, E., Forte, A., Gaido, L., Ghiselli, A., Gianoli, A., Italiano, A., Lusso, S., Luvisetto, M., Mastroserio, P., Mazzucato, M., Mura, D., Reale, M., Salconi, L., Sava, G., Serra, M., Spataro, F., Taurino, F., Tortone, G., Vaccarossa, L., Verlato, M., and Vita Finzi, G.

Published
2005
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36. Hospital Hygiene and Infection Prevention and Control in Italy: state of the art and perspectives

Author

Brusaferro, S, Arnoldo, L, Finzi, G, Mura, I, Auxilia, F, Pasquarella, C, Agodi, A and the GISIO Group (Agodi A, Arrigoni, C, Barchitta, M, Calella, G, Casini, B, Cristina, Ml, D'Errico, M, Laurenti, P, Masia, Md, Montagna, Mt, Olivieri, G, Orsi, A, Orsi, Gb, Pesapane, L, Ripabelli, G, Sodano, L, Squeri, R, Teti, V, Torregrossa, Mv, Torri, E, Zarrilli, R, Are, Bm, Brighenti, A, Mascipinto, S, Iannazzo, S, D'Ancona, Fp, Sessa, G, Motta, A, Appignanesi, R, Argiolas, F, Baldovin, T, Bargellini, A, Berdini, S, Boccia, G, Calagreti, G, Caldarulo, T, Campanella, F, Chiesa, R, Ciorba, V, Contrisciani, R, D'Alessandro, D, De Giglio, O, Fabiani, L, Fara, Gm, Giuliani, G, Laganà, P, Marani, A, Mattaliano, Ar, Molino, A, Montesano, M, Moretti, F, Moro, M, Moscato, U, Napoli, C, Nicolotti, N, Nobile, M, Novati, R, Palumbo, F, Piana, A, Privitera, G, Prospero, E, Quattrocchi, A, Righi, E, Romano Spica, V, Rossi, F, Rossini, A, Schieppati, S, Sotgiu, G, Tardivo, S, Torre, I, Valeriani, F, Veronesi, L, Zotti, C), Brusaferro, S., Arnoldo, L., Finzi, G., Mura, I., Auxilia, F., Pasquarella, C., Agodi, A., Pitzurra, M., Arrigoni, C., Barchitta, M., Calella, G., Casini, B., Cristina, M. L., D'Errico, M., Laurenti, P., Masia, M. D., Montagna, M. T., Olivieri, G., Orsi, A., Orsi, G. B., Pesapane, L., Ripabelli, G., Sodano, L., Squeri, R., Teti, V., Torregrossa, M. V., Torri, E., Zarrilli, R., Are, B. M., Brighenti, A., Mascipinto, S., Iannazzo, S., D'Ancona, F. P., Sessa, G., Motta, A., Appignanesi, R., Argiolas, F., Baldovin, T., Bargellini, A., Berdini, S., Boccia, G., Calagreti, G., Caldarulo, T., Campanella, F., Chiesa, R., Ciorba, V., Contrisciani, R., D'Alessandro, D., De Giglio, O., Fabiani, L., Fara, G. M., Giuliani, G., Lagana, P., Marani, A., Mattaliano, A. R., Molino, A., Montesano, M., Moretti, F., Moro, M., Moscato, U., Napoli, C., Nicolotti, N., Nobile, M., Novati, R., Palumbo, F., Piana, A., Privitera, G., Prospero, E., Quattrocchi, A., Righi, E., Romano Spica, V., Rossi, F., Rossini, A., Schieppati, S., Sotgiu, G., Tardivo, S., Torre, I., Valeriani, F., Veronesi, L., and Zotti, C.

Subjects
Adult, Male, Healthcare organisation Igiene ospedaliera, National Health Programs, Infection Prevention and Control, hospital hygiene, infection prevention and control, public health, environmental and occupational health, infectious diseases, igiene ospedaliera, organizzazione sanitaria, prevenzione e controllo delle infezioni, Attitude of Health Personnel, Health Promotion, Healthcare organisation, Iran, Nursing Staff, Hospital, Hospital Hygiene, Igiene ospedaliera, Hospital Hygiene, Infection Prevention and Control, Healthcare organisation Igiene ospedaliera, prevenzione e controllo delle infezioni, organizzazione sanitaria, Hospital Administration, Patient Education as Topic, Terminology as Topic, Medical Staff, Hospital, Humans, Igiene ospedaliera, prevenzione e controllo delle infezioni, organizzazione sanitaria, European Union, Hospitals, Teaching, Workplace, Occupational Health, Cross-Sectional Studie, Cross Infection, Infection Control, Healthcare organisation Parole chiave: Igiene ospedaliera, Analysis of Variance, Organizzazione sanitaria, Prevenzione e controllo delle infezioni, Europe, Italy, Health Facilities, Hygiene, Healthcare organisation, Igiene ospedaliera, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Infectious Diseases, Healthcare organisation, Hospital Hygiene, Infection Prevention and Control, Public Health, Environmental and Occupational Health, Infectious Diseases, Hospital Administrator, Female, Public Health, Patient Participation, Hospital Hygiene, Infection Prevention and Control, Healthcare organisation, Human
Abstract

Although hospital hygiene has a long history in Italy it is necessary to reflect about it because of the innovation in healthcare systems and because of the evolution due to European Union related activities. Different traditions exist in European countries about hospital hygiene and European Centre for Disease Prevention and Control (ECDC) adopted the term of "infection control and hospital hygiene" which includes all the engaged European healthcare professionals. We propose to modify hospital hygiene as "healthcare organisation hygiene" in order to focalise the attention to all care settings not only hospitals and to adopt the following definition: "all activities aimed to guarantee, in an appropriate, scientifically sound and efficient way, that structures and processes support healthcare practices in a safe comfortable and healthy environment both for patients, caregivers and healthcare workers". Hospital hygiene and its professionals, besides the long tradition, still remain a relevant pillar in guaranteeing quality and safety of healthcare in Italy.

Published
2018

37. Results of a survey of procedures for cleaning and disinfecting ambulances

Author

Nobile, M, Pasquarella, C, Baldovin, T, Brusaferro, S, Casini, B, Cristina, M L, D'Errico, M M, Finzi, G, Montagna, M T, Mura, I, Novati, R, Privitera, G, Ripabelli, G, Schirripa, G, Sodano, L, Vitali, P, Tardivo, S, Teti, V, Torregrossa, M V, Torri, E, Zarrilli, R, Agodi, A, Auxilia, F, Nobile, M, Pasquarella, C, Baldovin, T, Brusaferro, S, Casini, B, Cristina, Ml, D'Errico, Mm, Finzi, G, Montagna, Mt, Mura, I, Novati, R, Privitera, G, Ripabelli, G, Schirripa, G, Sodano, L, Vitali, P, Tardivo, S, Teti, V, Torregrossa, Mv, Torri, E, Zarrilli, R, Agodi, A, and Auxilia, F.

Subjects
procedure, Ambulances, Guidelines as Topic, Infection control, Cleaning and disinfection, Procedures, Ambulance, Medical, Surveys and Questionnaires, ambulanze, Humans, ambulances, infection control Parole chiave Sanificazione, mezzi di trasporto sanitari, procedures, Disinfection, Equipment Contamination, Household Work, Hygiene, Italy, Societies, Medical, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Infectious Diseases, Public Health, Societies
Abstract

In 2014, the Italian Study Group of Hospital Hygiene of the Italian Society of Hygiene, Preventive Medicine and Public Health (GISIO-SItI), in collaboration with the National Association of Medical Hospital Managers (ANMDO), conducted a survey on the availability of procedures for cleaning and disinfecting ambulances in order to assess the practices in use.An online questionnaire was prepared through the Survey Monkey® platform and a web link access was sent to a convenience sample of ANMDO doctors working in healthcare management in public and private healthcare facilities.Ninety-six questionnaires were collected (26% response rate). In 73% of cases there was a procedure for cleaning and disinfecting ambulances, which had been produced at a company level (67%) and involved various professionals. In 21% of cases the procedure had been prepared in expectation of an epidemic or following an epidemic (5%). The recommendations had been presented to the staff (90%), in 28% of cases through training events with verification of the knowledge acquired. Monitoring of the implementation of the procedure is planned in the majority of cases (88%), mainly through direct observation (92%). In 67% of cases the tender specifications for ambulance services did not include a section dedicated to cleaning and disinfection and, in the absence of a procedure, this was provided by the hospital in only 51% of case.This survey represented a first step towards the development of guidelines for standardising procedures and providing indications useful for their evaluation and monitoring their implementation.

Published
2018

42. Integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

Author

Fiorentino, T. V., Casiraghi, F., Davalli, A. M., Finzi, G., Rosa, S. L., Higgins, P. B., Abrahamian, G. A., Marando, A., Sessa, F., Perego, C., Guardado-Mendoza, R., Kamath, S., Ricotti, A., Fiorina, P., Daniele, G., Paez, A. M., Andreozzi, F., Bastarrachea, R. A., Comuzzie, A. G., Gastaldelli, A., Chavez, A. O., Di Cairano, E. S., Frost, P., Luzi, L., Dick, E. J., Halff, G. A., Defronzo, R. A., Folli, F., and LA ROSA, Stefano

Subjects
Insulin signaling, B cells, Glucose metabolism, Endocrinology
Published
2019

45. Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ros production in endothelial cells and cardiomyocytes

Author

Focaccetti, C, Bruno, A, Magnani, E, Bartolini, D, Principi, E, Dallaglio, K, Bucci, E, Finzi, G, Sessa, F, Noonan, D, Albini, A, Focaccetti C, Bruno A, Magnani E, Bartolini D, Principi E, Dallaglio K, Bucci EO, Finzi G, Sessa F, Noonan DM, Albini A, Focaccetti, C, Bruno, A, Magnani, E, Bartolini, D, Principi, E, Dallaglio, K, Bucci, E, Finzi, G, Sessa, F, Noonan, D, Albini, A, Focaccetti C, Bruno A, Magnani E, Bartolini D, Principi E, Dallaglio K, Bucci EO, Finzi G, Sessa F, Noonan DM, and Albini A

Abstract

Antimetabolites are a class of effective anticancer drugs interfering in essential biochemical processes. 5-Fluorouracil (5-FU) and its prodrug Capecitabine are widely used in the treatment of several solid tumors (gastro-intestinal, gynecological, head and neck, breast carcinomas). Therapy with fluoropyrimidines is associated with a wide range of adverse effects, including diarrhea, dehydration, abdominal pain, nausea, stomatitis, and hand-foot syndrome. Among the 5-FU side effects, increasing attention is given to cardiovascular toxicities induced at different levels and intensities. Since the mechanisms related to 5-FU-induced cardiotoxicity are still unclear, we examined the effects of 5-FU on primary cell cultures of human cardiomyocytes and endothelial cells, which represent two key components of the cardiovascular system. We analyzed at the cellular and molecular level 5-FU effects on cell proliferation, cell cycle, survival and induction of apoptosis, in an experimental cardioncology approach. We observed autophagic features at the ultrastructural and molecular levels, in particular in 5-FU exposed cardiomyocytes. Reactive oxygen species (ROS) elevation characterized the endothelial response. These responses were prevented by a ROS scavenger. We found induction of a senescent phenotype on both cell types treated with 5-FU. In vivo, in a xenograft model of colon cancer, we showed that 5-FU treatment induced ultrastructural changes in the endothelium of various organs. Taken together, our data suggest that 5-FU can affect, both at the cellular and molecular levels, two key cell types of the cardiovascular system, potentially explaining some manifestations of 5-FU-induced cardiovascular toxicity.

Published
2015

48. Further phenotypic heterogeneity of CoQ10 deficiency associated with Steroid Resistant Nephrotic Syndrome and novel COQ2 and COQ6 variants

Author

Gigante, M., Diella, S., Santangelo, L., Trevisson, E., Acosta, M. J., Amatruda, M., Finzi, G., Caridi, G., Murer, L., Accetturo, M., Ranieri, E., Ghiggeri, G. M., Giordano, M., Grandaliano, Giuseppe, Salviati, L., and Gesualdo, L.

Subjects
Male, Mitochondrial Diseases, Muscle Weakness, Nephrotic Syndrome, Ubiquinone, DNA Mutational Analysis, COQ2, yeast model, COQ6, Pedigree, Coenzyme Q10 deficiency, Mutation, Humans, Settore MED/14 - NEFROLOGIA, Ataxia, Computer Simulation, Female, Steroid Resistant Nephrotic Syndrome
Published
2017

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