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† Lymphocytes from psoriatic patients were found to contain reduced levels of adenosine 3′:5′-cyclic phosphate, guanosine 5′-cyclic phosphoric acid, and prostaglandin E, as compared with lymphocytes from normal subjects. The difference in prostaglandin F levels between psoriatic and control subjects was not statistically significant. These results could point to an immunologic defect in the immune system in psoriasis.(Arch Dermatol 116:427-428, 1980)